Partner ID 6033
Name High affinity interleukin-8 receptor A
Synonyms 7835
Gene name CXCR1
General function Involved in interleukin-8 receptor activity
Specific function Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity
Gene sequence + ...

ATGTCAAATATTACAGATCCACAGATGTGGGATTTTGATGATCTAAATTTCACTGGCATGCCACCTGCAGATGAAGATTACAGCCCCTGTATGCTAGAAACTGAGACACTCAACAAGTATGTTGTGATCATCGCCTATGCCCTAGTGTTCCTGCTGAGCCTGCTGGGAAACTCCCTGGTGATGCTGGTCATCTTATACAGCAGGGTCGGCCGCTCCGTCACTGATGTCTACCTGCTGAACCTGGCCTTGGCCGACCTACTCTTTGCCCTGACCTTGCCCATCTGGGCCGCCTCCAAGGTGAATGGCTGGATTTTTGGCACATTCCTGTGCAAGGTGGTCTCACTCCTGAAGGAAGTCAACTTCTACAGTGGCATCCTGCTGTTGGCCTGCATCAGTGTGGACCGTTACCTGGCCATTGTCCATGCCACACGCACACTGACCCAGAAGCGTCACTTGGTCAAGTTTGTTTGTCTTGGCTGCTGGGGACTGTCTATGAATCTGTCCCTGCCCTTCTTCCTTTTCCGCCAGGCTTACCATCCAAACAATTCCAGTCCAGTTTGCTATGAGGTCCTGGGAAATGACACAGCAAAATGGCGGATGGTGTTGCGGATCCTGCCTCACACCTTTGGCTTCATCGTGCCGCTGTTTGTCATGCTGTTCTGCTATGGATTCACCCTGCGTACACTGTTTAAGGCCCACATGGGGCAGAAGCACCGAGCCATGAGGGTCATCTTTGCTGTCGTCCTCATCTTCCTGCTTTGCTGGCTGCCCTACAACCTGGTCCTGCTGGCAGACACCCTCATGAGGACCCAGGTGATCCAGGAGAGCTGTGAGCGCCGCAACAACATCGGCCGGGCCCTGGATGCCACTGAGATTCTGGGATTTCTCCATAGCTGCCTCAACCCCATCATCTACGCCTTCATCGGCCAAAATTTTCGCCATGGATTCCTCAAGATCCTGGCTATGCATGGCCTGGTCAGCAAGGAGTTCTTGGCACGTCATCGTGTTACCTCCTACACTTCTTCGTCTGTCAATGTCTCTTCCAACCTCTGA

Protein sequence + ...

MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL

GO Classification
component
cell
intrinsic to membrane
integral to membrane
membrane
function
hematopoietin/interferon-class (D200-domain) cytokine receptor activity
signal transducer activity
receptor activity
interleukin receptor activity
transmembrane receptor activity
G-protein coupled receptor activity
interleukin-8 receptor activity
rhodopsin-like receptor activity
process
cellular process
cell communication
signal transduction
cell surface receptor linked signal transduction
G-protein coupled receptor protein signaling pathway
response to stimulus
response to abiotic stimulus
response to chemical stimulus
chemotaxis
See more information at   →   www.drugbank.ca
Id Name
DB01009 Ketoprofen
Id Name
DB00005 Etanercept
DB00035 Desmopressin
DB00041 Aldesleukin
DB00062 Human Serum Albumin
DB00070 Hyaluronidase
DB00091 Cyclosporine
DB00137 Xanthophyll
DB00139 Succinic acid
DB00140 Riboflavin
DB00143 Glutathione
DB00154 gamma-Homolinolenic acid
DB00158 Folic Acid
DB00159 Icosapent
DB00168 Aspartame
DB00169 Cholecalciferol
DB00175 Pravastatin
DB00176 Fluvoxamine
DB00177 Valsartan
DB00181 Baclofen
DB00184 Nicotine
DB00188 Bortezomib
DB00191 Phentermine
DB00196 Fluconazole
DB00197 Troglitazone
DB00198 Oseltamivir
DB00199 Erythromycin
DB00201 Caffeine
DB00203 Sildenafil
DB00205 Pyrimethamine
DB00208 Ticlopidine
DB00213 Pantoprazole
DB00214 Torasemide
DB00216 Eletriptan
DB00220 Nelfinavir
DB00222 Glimepiride
DB00224 Indinavir
DB00227 Lovastatin
DB00228 Enflurane
DB00229 Cefotiam
DB00231 Temazepam
DB00233 Aminosalicylic Acid
DB00238 Nevirapine
DB00244 Mesalazine
DB00250 Dapsone
DB00252 Phenytoin
DB00254 Doxycycline
DB00255 Diethylstilbestrol
DB00257 Clotrimazole
DB00259 Sulfanilamide
DB00263 Sulfisoxazole
DB00266 Dicumarol
DB00274 Cefmetazole
DB00277 Theophylline
DB00279 Liothyronine
DB00281 Lidocaine
DB00285 Venlafaxine
DB00286 Conjugated Estrogens
DB00291 Chlorambucil
DB00295 Morphine
DB00300 Tenofovir
DB00307 Bexarotene
DB00311 Ethoxzolamide
DB00313 Valproic Acid
DB00316 Acetaminophen
DB00317 Gefitinib
DB00319 Piperacillin
DB00321 Amitriptyline
DB00323 Tolcapone
DB00327 Hydromorphone
DB00328 Indomethacin
DB00333 Methadone
DB00334 Olanzapine
DB00338 Omeprazole
DB00342 Terfenadine
DB00343 Diltiazem
DB00345 Aminohippurate
DB00347 Trimethadione
DB00350 Minoxidil
DB00352 Thioguanine
DB00359 Sulfadiazine
DB00360 Tetrahydrobiopterin
DB00363 Clozapine
DB00364 Sucralfate
DB00365 Grepafloxacin
DB00369 Cidofovir
DB00370 Mirtazapine
DB00374 Treprostinil
DB00381 Amlodipine
DB00390 Digoxin
DB00396 Progesterone
DB00398 Sorafenib
DB00402 Eszopiclone
DB00404 Alprazolam
DB00412 Rosiglitazone
DB00415 Ampicillin
DB00418 Secobarbital
DB00420 Promazine
DB00421 Spironolactone
DB00425 Zolpidem
DB00430 Cefpiramide
DB00432 Trifluridine
DB00437 Allopurinol
DB00438 Ceftazidime
DB00439 Cerivastatin
DB00440 Trimethoprim
DB00444 Teniposide
DB00446 Chloramphenicol
DB00448 Lansoprazole
DB00451 Levothyroxine
DB00454 Meperidine
DB00455 Loratadine
DB00456 Cefalotin
DB00459 Acitretin
DB00461 Nabumetone
DB00465 Ketorolac
DB00468 Quinine
DB00469 Tenoxicam
DB00470 Dronabinol
DB00471 Montelukast
DB00472 Fluoxetine
DB00477 Chlorpromazine
DB00480 Lenalidomide
DB00481 Raloxifene
DB00482 Celecoxib
DB00493 Cefotaxime
DB00495 Zidovudine
DB00500 Tolmetin
DB00501 Cimetidine
DB00502 Haloperidol
DB00503 Ritonavir
DB00512 Vancomycin
DB00514 Dextromethorphan
DB00515 Cisplatin
DB00520 Caspofungin
DB00529 Foscarnet
DB00530 Erlotinib
DB00531 Cyclophosphamide
DB00532 Mephenytoin
DB00533 Rofecoxib
DB00536 Guanidine
DB00540 Nortriptyline
DB00544 Fluorouracil
DB00549 Zafirlukast
DB00554 Piroxicam
DB00559 Bosentan
DB00563 Methotrexate
DB00564 Carbamazepine
DB00567 Cephalexin
DB00568 Cinnarizine
DB00573 Fenoprofen
DB00576 Sulfamethizole
DB00577 Valaciclovir
DB00578 Carbenicillin
DB00580 Valdecoxib
DB00582 Voriconazole
DB00583 L-Carnitine
DB00584 Enalapril
DB00586 Diclofenac
DB00595 Oxytetracycline
DB00603 Medroxyprogesterone
DB00604 Cisapride
DB00605 Sulindac
DB00606 Cyclothiazide
DB00607 Nafcillin
DB00608 Chloroquine
DB00613 Amodiaquine
DB00617 Paramethadione
DB00619 Imatinib
DB00620 Triamcinolone
DB00622 Nicardipine
DB00624 Testosterone
DB00625 Efavirenz
DB00635 Prednisone
DB00641 Simvastatin
DB00647 Propoxyphene
DB00649 Stavudine
DB00650 Leucovorin
DB00655 Estrone
DB00661 Verapamil
DB00665 Nilutamide
DB00667 Histamine Phosphate
DB00668 Epinephrine
DB00669 Sumatriptan
DB00672 Chlorpropamide
DB00673 Aprepitant
DB00675 Tamoxifen
DB00678 Losartan
DB00679 Thioridazine
DB00682 Warfarin
DB00688 Mycophenolate mofetil
DB00693 Fluorescein
DB00695 Furosemide
DB00701 Amprenavir
DB00703 Methazolamide
DB00705 Delavirdine
DB00709 Lamivudine
DB00711 Diethylcarbamazine
DB00712 Flurbiprofen
DB00715 Paroxetine
DB00717 Norethindrone
DB00718 Adefovir Dipivoxil
DB00720 Clodronate
DB00726 Trimipramine
DB00728 Rocuronium
DB00731 Nateglinide
DB00738 Pentamidine
DB00741 Hydrocortisone
DB00743 Gadobenate Dimeglumine
DB00744 Zileuton
DB00745 Modafinil
DB00748 Carbinoxamine
DB00749 Etodolac
DB00752 Tranylcypromine
DB00753 Isoflurane
DB00755 Tretinoin
DB00757 Dolasetron
DB00758 Clopidogrel
DB00759 Tetracycline
DB00762 Irinotecan
DB00763 Methimazole
DB00764 Mometasone
DB00770 Alprostadil
DB00773 Etoposide
DB00776 Oxcarbazepine
DB00779 Nalidixic Acid
DB00780 Phenelzine
DB00783 Estradiol
DB00784 Mefenamic acid
DB00787 Acyclovir
DB00788 Naproxen
DB00794 Primidone
DB00795 Sulfasalazine
DB00796 Candesartan
DB00798 Gentamicin
DB00799 Tazarotene
DB00802 Alfentanil
DB00812 Phenylbutazone
DB00814 Meloxicam
DB00815 Sodium lauryl sulfate
DB00818 Propofol
DB00819 Acetazolamide
DB00821 Carprofen
DB00822 Disulfiram
DB00827 Cinoxacin
DB00829 Diazepam
DB00835 Brompheniramine
DB00836 Loperamide
DB00843 Donepezil
DB00850 Perphenazine
DB00856 Chlorphenesin
DB00857 Terbinafine
DB00860 Prednisolone
DB00861 Diflunisal
DB00863 Ranitidine
DB00864 Tacrolimus
DB00869 Dorzolamide
DB00870 Suprofen
DB00876 Eprosartan
DB00880 Chlorothiazide
DB00884 Risedronate
DB00887 Bumetanide
DB00891 Sulfapyridine
DB00897 Triazolam
DB00898 Ethanol
DB00900 Didanosine
DB00903 Ethacrynic acid
DB00904 Ondansetron
DB00907 Cocaine
DB00908 Quinidine
DB00912 Repaglinide
DB00916 Metronidazole
DB00917 Dinoprostone
DB00918 Almotriptan
DB00921 Buprenorphine
DB00927 Famotidine
DB00931 Methacycline
DB00936 Salicyclic acid
DB00938 Salmeterol
DB00939 Meclofenamic acid
DB00943 Zalcitabine
DB00945 Acetylsalicylic acid
DB00946 Phenprocoumon
DB00950 Fexofenadine
DB00951 Isoniazid
DB00963 Bromfenac
DB00967 Desloratadine
DB00969 Alosetron
DB00972 Azelastine
DB00975 Dipyridamole
DB00977 Ethinyl Estradiol
DB00983 Formoterol
DB00988 Dopamine
DB00991 Oxaprozin
DB00995 Auranofin
DB00999 Hydrochlorothiazide
DB01004 Ganciclovir
DB01007 Tioconazole
DB01009 Ketoprofen
DB01014 Balsalazide
DB01015 Sulfamethoxazole
DB01016 Glyburide
DB01017 Minocycline
DB01018 Guanfacine
DB01023 Felodipine
DB01026 Ketoconazole
DB01028 Methoxyflurane
DB01029 Irbesartan
DB01032 Probenecid
DB01033 Mercaptopurine
DB01036 Tolterodine
DB01037 Selegiline
DB01039 Fenofibrate
DB01041 Thalidomide
DB01044 Gatifloxacin
DB01045 Rifampin
DB01050 Ibuprofen
DB01051 Novobiocin
DB01053 Penicillin G
DB01056 Tocainide
DB01059 Norfloxacin
DB01060 Amoxicillin
DB01062 Oxybutynin
DB01065 Melatonin
DB01067 Glipizide
DB01068 Clonazepam
DB01069 Promethazine
DB01072 Atazanavir
DB01075 Diphenhydramine
DB01076 Atorvastatin
DB01079 Tegaserod
DB01082 Streptomycin
DB01092 Ouabain
DB01095 Fluvastatin
DB01097 Leflunomide
DB01098 Rosuvastatin
DB01101 Capecitabine
DB01104 Sertraline
DB01110 Miconazole
DB01115 Nifedipine
DB01117 Atovaquone
DB01118 Amiodarone
DB01120 Gliclazide
DB01124 Tolbutamide
DB01128 Bicalutamide
DB01129 Rabeprazole
DB01131 Proguanil
DB01132 Pioglitazone
DB01136 Carvedilol
DB01137 Levofloxacin
DB01138 Sulfinpyrazone
DB01140 Cefadroxil
DB01142 Doxepin
DB01144 Dichlorphenamide
DB01147 Cloxacillin
DB01154 Thiamylal
DB01156 Bupropion
DB01159 Halothane
DB01160 Dinoprost Tromethamine
DB01165 Ofloxacin
DB01171 Moclobemide
DB01174 Phenobarbital
DB01176 Cyclizine
DB01177 Idarubicin
DB01181 Ifosfamide
DB01182 Propafenone
DB01183 Naloxone
DB01184 Domperidone
DB01189 Desflurane
DB01191 Dexfenfluramine
DB01195 Flecainide
DB01197 Captopril
DB01198 Zopiclone
DB01201 Rifapentine
DB01211 Clarithromycin
DB01212 Ceftriaxone
DB01217 Anastrozole
DB01218 Halofantrine
DB01221 Ketamine
DB01229 Paclitaxel
DB01232 Saquinavir
DB01234 Dexamethasone
DB01236 Sevoflurane
DB01237 Bromodiphenhydramine
DB01240 Epoprostenol
DB01241 Gemfibrozil
DB01242 Clomipramine
DB01248 Docetaxel
DB01259 Lapatinib
DB01261 Sitagliptin
DB01268 Sunitinib
DB01274 Arformoterol
DB01283 Lumiracoxib
DB01294 Bismuth Subsalicylate
DB01303 Oxtriphylline
DB01307 Insulin Detemir
DB01320 Fosphenytoin
DB01326 Cefamandole
DB01327 Cefazolin
DB01328 Cefonicid
DB01329 Cefoperazone
DB01330 Cefotetan
DB01333 Cefradine
DB01355 Hexobarbital
DB01357 Mestranol
DB01361 Troleandomycin
DB01381 Ginkgo biloba
DB01393 Bezafibrate
DB01394 Colchicine
DB01395 Drospirenone
DB01396 Digitoxin
DB01397 Magnesium salicylate
DB01398 Salicylate-sodium
DB01399 Salsalate
DB01401 Trisalicylate-choline
DB01404 Ginseng
DB01411 Pranlukast
DB01414 Cefacetrile
DB01418 Acenocoumarol
DB01419 Antrafenine
DB01424 Aminophenazone
DB01435 Antipyrine
DB01544 Flunitrazepam
DB01581 Sulfamerazine
DB01582 Sulfamethazine
DB01583 Liotrix
DB01586 Ursodeoxycholic acid
DB01587 Ketazolam
DB01589 Quazepam
DB01597 Cilastatin
DB01600 Tiaprofenic acid
DB01601 Lopinavir
DB01614 Acepromazine
DB01621 Pipotiazine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01628 Etoricoxib
DB01650 trans-2-hydroxycinnamic acid
DB01698 Rutin
DB01837 O-Acetylserine
DB01892 Hyperforin
DB02047 2-(1,1'-Biphenyl-4-Yl)Propanoic Acid
DB02110 Protoporphyrin Ix Containing Co
DB02123 Glycochenodeoxycholic Acid
DB02198 2-Bromoacetyl Group
DB02266 Flufenamic Acid
DB02315 Cyclic Guanosine Monophosphate
DB02379 Beta-D-Glucose
DB02507 4-Hydroxy-3-[(1s)-3-Oxo-1-Phenylbutyl]-2h-Chromen-2-One
DB02527 Cyclic Adenosine Monophosphate
DB02659 Cholic Acid
DB02687 Beta-D-Mannose
DB02691 N-Cholylglycine
DB02709 Resveratrol
DB02773 (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid
DB02944 Alpha-D-Mannose
DB03014 Heme
DB03193 Stearic acid
DB03317 Heme C
DB03477 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
DB03553 Glutaric Acid
DB03585 Oxyphenbutazone
DB03600 Decanoic Acid
DB03619 Deoxycholic Acid
DB03667 Acetic Acid Salicyloyl-Amino-Ester
DB03752 P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid
DB03753 Flurbiprofen Methyl Ester
DB03783 Phenacetin
DB03793 Benzoic Acid
DB03796 Palmitic Acid
DB03866 Prostaglandin G2
DB03902 Oxalic Acid
DB04133 Degraded Cephaloridine
DB04216 Quercetin
DB04224 Oleic Acid
DB04348 Taurocholic Acid
DB04519 Caprylic acid
DB04552 Niflumic Acid
DB04557 Arachidonic Acid
DB04573 Estriol
DB04574 Estropipate
DB04630 Aldosterone
DB04711 Iodipamide
DB04743 Nimesulide
DB04817 Dipyrone
DB04831 Ticrynafen
DB04841 Flunarizine
DB04855 Dronedarone
DB04868 Nilotinib
DB04898 Ximelagatran
DB04920 Clevidipine
DB04938 Ospemifene
DB05109 Trabectedin
DB05294 Vandetanib
DB05521 Telaprevir
DB05812 Abiraterone
DB06150 Sulfadimethoxine
DB06151 Acetylcysteine
DB06201 Rufinamide
DB06204 Tapentadol
DB06209 Prasugrel
DB06210 Eltrombopag
DB06268 Sitaxentan
DB06335 Saxagliptin
DB06589 Pazopanib
DB06594 Agomelatine
DB06605 Apixaban
DB06697 Artemether
DB06705 Gadofosveset trisodium
DB06710 Methyltestosterone
DB06712 Nilvadipine
DB06716 Fospropofol
DB06725 Lornoxicam
DB06729 Sulfaphenazole
DB06770 Benzyl alcohol
DB06772 Cabazitaxel
DB06802 Nepafenac
DB06803 Niclosamide
DB06804 Nonoxynol-9
DB07402 AZAPROPAZONE
DB07517 3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPIONIC
DB07981 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1R)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE
DB07983 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID
DB07984 2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE
DB07992 3-SULFOOXY-1H-INDOLE
DB08231 MYRISTIC ACID
DB08298 (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
DB08607 (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE
DB08735 4-HYDROXY-3-[(1S,3R)-3-HYDROXY-1-PHENYLBUTYL]-2H-CHROMEN-2-ONE
DB08736 4-HYDROXY-3-[(1S,3S)-3-HYDROXY-1-PHENYLBUTYL]-2H-CHROMEN-2-ONE
DB08798 Sulfamoxole
DB08814 Triflusal
DB08819 Tafluprost
DB08820 Ivacaftor
DB08828 Vismodegib
DB08834 Tauroursodeoxycholic acid
DB08836 Temocapril
DB08837 Tetraethylammonium
DB08846 Ellagic Acid
DB08860 Pitavastatin
DB08875 Cabozantinib
DB08881 Vemurafenib
DB08884 Gadoxetate
DB08893 Mirabegron
DB08896 Regorafenib
DB08899 Enzalutamide
DB08901 Ponatinib
DB08907 Canagliflozin
DB08910 Pomalidomide
DB08911 Trametinib
DB08912 Dabrafenib