DT-Web

DB02123 - Glycochenodeoxycholic Acid


Identification
Name Glycochenodeoxycholic Acid
Accession Number DB02123 (EXPT00909)
Type small molecule
Description A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 449.6233
Groups experimental
Monoisotopic Weight 449.314123491
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


7-alpha-hydroxysteroid dehydrogenase
Name 7-alpha-hydroxysteroid dehydrogenase
Gene Name hdhA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3117

Transporters


Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions substrate,inhibitor
References
  • Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. - Pubmed
  • Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. - Pubmed
  • Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5. - Pubmed
DTHybrid score 0.3493
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate,inhibitor
References
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ: Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology. 1994 Aug;20(2):411-6. - Pubmed
  • Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW: Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G829-39. Epub 2003 Jul 3. - Pubmed
DTHybrid score 0.3778
Ileal sodium/bile acid cotransporter
Name Ileal sodium/bile acid cotransporter
Gene Name SLC10A2
Actions substrate
References
  • Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, Dawson PA: Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69. - Pubmed
  • Walters HC, Craddock AL, Fusegawa H, Willingham MC, Dawson PA: Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1188-200. - Pubmed
DTHybrid score 0.4182
Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions substrate
References
  • Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5. - Pubmed
DTHybrid score 0.3696

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.1088
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.105
6142 Solute carrier family 22 member 8 SLC22A8 0.0834
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.078
4512 Cytochrome P450 3A4 CYP3A4 0.0713
1729 Solute carrier family 22 member 6 SLC22A6 0.0693
862 Multidrug resistance-associated protein 1 ABCC1 0.0663
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0624
4924 Cytochrome P450 2C8 CYP2C8 0.0587
2164 Multidrug resistance-associated protein 4 ABCC4 0.0578
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0552
4757 Cytochrome P450 2C9 CYP2C9 0.0499
6145 Solute carrier family 22 member 1 SLC22A1 0.0471
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0466
4118 Cytochrome P450 3A5 CYP3A5 0.0458
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0456
587 Serum albumin ALB 0.0409
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0402
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0398
6016 Cytochrome P450 2C19 CYP2C19 0.0394
6107 Cytochrome P450 3A7 CYP3A7 0.0383
3587 Gastrotropin FABP6 0.038
6143 Solute carrier family 22 member 7 SLC22A7 0.0379
338 DNA polymerase UL30 0.037
379 DNA polymerase UL54 0.037
697 DNA polymerase ORF28 0.037
2482 DNA polymerase 43 0.037
4104 DNA polymerase BALF5 0.037
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0356
6148 Multidrug resistance-associated protein 7 ABCC10 0.0322
6013 Cytochrome P450 2E1 CYP2E1 0.0321
4119 Cytochrome P450 2D6 CYP2D6 0.0315
33 Cystine/glutamate transporter SLC7A11 0.0305
1024 Solute carrier family 22 member 11 SLC22A11 0.0304
136 Estrogen receptor ESR1 0.0276
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0269
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0257
6024 Cytochrome P450 1A1 CYP1A1 0.0255
6167 Organic solute transporter subunit beta OSTB 0.0251
6166 Organic solute transporter subunit alpha OSTA 0.0251
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0238
4200 Cytochrome P450 1A2 CYP1A2 0.0225
509 Thymidine kinase TK 0.0216
570 Thymidine kinase TK 0.0216
2559 Thymidine kinase TK 0.0216
3430 Thymidine kinase tdk 0.0216
3518 Thymidine kinase TK 0.0216
5301 Thymidine kinase tdk 0.0216
5771 Thymidine kinase ORF36 0.0216
7009 Thymidine kinase ORF36 0.0216
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0214
1898 Cytochrome P450 1B1 CYP1B1 0.0208
6144 Solute carrier family 22 member 2 SLC22A2 0.0205
6030 Cytochrome P450 2B6 CYP2B6 0.0204
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0201
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0194
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0194
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0191
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0188
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0187
738 Monocarboxylate transporter 1 SLC16A1 0.0179
594 Thyroxine-binding globulin SERPINA7 0.0179
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0171
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0171
758 Thyroid hormone receptor alpha THRA 0.0167
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0159
2391 Ferrochelatase hemH 0.0157
6502 Ferrochelatase DKFZp686P18130 0.0157
1591 Ferrochelatase, mitochondrial FECH 0.0157
683 Potassium transporter GK0582 0.0156
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0156
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0156
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0152
346 Thyroid hormone receptor beta-1 THRB 0.015
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.015
5718 Cytochrome P450 2A6 CYP2A6 0.0139
6137 Multidrug resistance-associated protein 6 ABCC6 0.0138
2417 Chloramphenicol acetyltransferase cat 0.0136
3278 Chloramphenicol acetyltransferase cat 0.0136
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0135
6493 Cytochrome c oxidase subunit 6C COX6C 0.0134
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0134
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0134
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0134
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0134
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0134
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0134
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0133
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0133
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0133
6559 Cytochrome c oxidase subunit 2 ctaC 0.0133
6669 Cytochrome c oxidase subunit 2 ctaC 0.0133
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0133
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0133
6558 Cytochrome c oxidase subunit 1 ctaD 0.0133
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.013
737 Mineralocorticoid receptor NR3C2 0.0129
380 Cytochrome P450 17A1 CYP17A1 0.0126
290 Prostaglandin G/H synthase 2 PTGS2 0.0125
3811 Cytochrome P450 19A1 CYP19A1 0.0125
2540 Choloylglycine hydrolase cbh 0.0124
4604 Liver carboxylesterase 1 CES1 0.012
3270 Elongation factor G fusA 0.0119
517 Alcohol dehydrogenase 1C ADH1C 0.0118
118 Organic cation/carnitine transporter 2 SLC22A5 0.0118
6147 Solute carrier family 22 member 3 SLC22A3 0.0118
3809 Estrogen-related receptor gamma ESRRG 0.0116
904 Glutathione S-transferase P GSTP1 0.0116
373 Transthyretin TTR 0.0115
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0115
6501 Fatty acid-binding protein, liver FABP1 0.0114
2808 Chloramphenicol acetyltransferase 3 cat3 0.0113
49 Endothelin B receptor EDNRB 0.0113
663 Solute carrier family 12 member 4 SLC12A4 0.0112
53 Solute carrier family 12 member 5 SLC12A5 0.0112
244 Angiotensin-converting enzyme ACE 0.0108
578 Endothelin-1 receptor EDNRA 0.0106
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0106
833 Organic cation/carnitine transporter 1 SLC22A4 0.0106
756 Sex hormone-binding globulin SHBG 0.0105
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0105
887 DNA gyrase subunit B gyrB 0.0105
4150 DNA gyrase subunit B gyrB 0.0105
6225 DNA gyrase subunit B gyrB 0.0105
310 Solute carrier family 12 member 2 SLC12A2 0.0104
6149 Solute carrier family 22 member 10 SLC22A10 0.0101
871 Glucocorticoid receptor NR3C1 0.01
6151 Monocarboxylate transporter 10 SLC16A10 0.0098
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0097
6500 Phospholipase A2 PLA2G1B 0.0093
146 Androgen receptor AR 0.0089
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0088
6031 Cytochrome P450 3A43 CYP3A43 0.0088
199 Monocarboxylate transporter 8 SLC16A2 0.0083
558 Solute carrier family 12 member 1 SLC12A1 0.008
468 Cytochrome P450 4A11 CYP4A11 0.0078
869 Estrogen receptor beta ESR2 0.0078
6136 Multidrug resistance-associated protein 5 ABCC5 0.0075
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0069
4472 Glucose 1-dehydrogenase Not Available 0.0069
4423 Levodione reductase lvr 0.0069
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0069
4428 Redox-sensing transcriptional repressor rex rex 0.0069
4497 Benzyl alcohol dehydrogenase xylB 0.0069
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0069
4443 Quinate/shikimate dehydrogenase ydiB 0.0069
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0069
4500 L-lactate dehydrogenase 2 ldh2 0.0069
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0069
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0069
4414 Dehydrogenase TT_P0035 0.0069
2350 3-isopropylmalate dehydrogenase leuB 0.0069
3092 3-isopropylmalate dehydrogenase leuB 0.0069
4418 AGR_L_3209p AGR_L_3209 0.0069
4507 Alanine dehydrogenase ald 0.0069
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0069
4455 Glycerol dehydrogenase gldA 0.0069
4449 ADP-ribosyltransferase Not Available 0.0069
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0069
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0069
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0069
4502 Formate dehydrogenase Not Available 0.0069
3729 Citrate synthase gltA 0.0069
4575 Citrate synthase cit 0.0069
4580 Citrate synthase gltA 0.0069
4435 L-aspartate dehydrogenase nadX 0.0069
4451 Vip2Ac vip2Ac 0.0069
4467 Alpha-glucosidase, putative TM_0752 0.0069
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0069
4447 Hypothetical protein yhfP yhfP 0.0069
3381 Alcohol dehydrogenase Not Available 0.0069
4508 Alcohol dehydrogenase adhA 0.0069
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0069
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0069
3726 D-3-phosphoglycerate dehydrogenase serA 0.0069
4291 D-3-phosphoglycerate dehydrogenase serA 0.0069
4487 Transcriptional regulator nadR nadR 0.0069
731 HIV-1 protease HIV-1 protease 0.0067
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0065
161 Tubulin beta chain TUBB 0.0065
312 Tubulin beta chain TUB2 0.0065
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0064
20 Prostaglandin G/H synthase 1 PTGS1 0.0062
469 Annexin A1 ANXA1 0.0061
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0061
4509 Acetoin(diacetyl) reductase budC 0.006
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.006
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.006
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.006
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.006
4427 TDP-glucose-4,6-dehydratase desIV 0.006
4498 Ornithine cyclodeaminase PP3533 0.006
4503 NADPH-flavin oxidoreductase frp 0.006
4439 Ferredoxin reductase bphA4 0.006
4486 Phenol 2-hydroxylase component B pheA2 0.006
2424 L-lactate dehydrogenase ldh 0.006
2641 L-lactate dehydrogenase Not Available 0.006
4437 L-lactate dehydrogenase ldh 0.006
4442 L-lactate dehydrogenase ldh 0.006
2336 2,3-diketo-L-gulonate reductase dlgD 0.006
126 D-lactate dehydrogenase dld 0.006
3545 D-lactate dehydrogenase Not Available 0.006
4510 D-lactate dehydrogenase ldhA 0.006
3177 dTDP-glucose 4,6-dehydratase rfbB 0.006
4499 dTDP-glucose 4,6-dehydratase rmlB 0.006
2018 Deoxyhypusine synthase DHPS 0.006
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.006
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.006
4482 UDP-galactose 4-epimerase galE 0.006
3615 Dihydrodipicolinate reductase dapB 0.006
3618 Dihydrodipicolinate reductase dapB 0.006
4462 Dihydrodipicolinate reductase dapB 0.006
4496 C-terminal-binding protein 1 CTBP1 0.006
2393 Maltose-6'-phosphate glucosidase glvA 0.006
4450 Iota toxin component Ia Not Available 0.006
4477 Dihydrolipoyl dehydrogenase lpdV 0.006
5077 Dihydrolipoyl dehydrogenase Not Available 0.006
5117 Dihydrolipoyl dehydrogenase lpd 0.006
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.006
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.006
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.006
2591 Urocanate hydratase hutU 0.006
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.006
2967 CDP-paratose 2-epimerase rfbE 0.006
3081 3-dehydroquinate synthase aroB 0.006
2507 Diphtheria toxin Not Available 0.006
2538 6-phospho-beta-glucosidase bglT bglT 0.006
6218 Pannexin-1 PANX1 0.006
131 Synaptic vesicular amine transporter SLC18A2 0.0057
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0055
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0055
4504 WbpP Not Available 0.0055
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0055
711 UDP-glucose 6-dehydrogenase UGDH 0.0055
3672 UDP-glucose 6-dehydrogenase hasB 0.0055
2683 Mono-ADP-ribosyltransferase C3 C3 0.0055
3367 GDP-mannose 6-dehydrogenase algD 0.0055
4440 NADH peroxidase npr 0.0055
4343 Alpha-glucosidase aglA 0.0055
4318 Siroheme synthase cysG 0.0055
6042 Prostaglandin reductase 2 PTGR2 0.0055
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0055
816 Biliverdin reductase A BLVRA 0.0054
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0054
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0054
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0054
63 Malate dehydrogenase mdh 0.0054
2329 Malate dehydrogenase mdh 0.0054
3445 Malate dehydrogenase mdh 0.0054
4420 Malate dehydrogenase mdh 0.0054
4438 Malate dehydrogenase mdh 0.0054
4476 Mannitol dehydrogenase mtlD 0.0054
3941 Amine oxidase [flavin-containing] A MAOA 0.0054
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0054
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0053
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0052
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0052
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0052
2826 Glucose--fructose oxidoreductase gfo 0.0052
3191 Histidinol dehydrogenase hisD 0.0052
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0052
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0052
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0052
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0052
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0052
2617 Nitric oxide synthase oxygenase nos 0.0052
2701 Nitric oxide synthase oxygenase nos 0.0052
3070 Adenosylhomocysteinase AHCY 0.0052
4424 Adenosylhomocysteinase PFE1050w 0.0052
6278 Adenosylhomocysteinase ahcY 0.0052
396 Alcohol dehydrogenase 4 ADH4 0.0052
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0052
597 Dihydropteridine reductase QDPR 0.0052
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0052
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0052
646 Malate dehydrogenase, cytoplasmic MDH1 0.0052
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0052
328 Sorbitol dehydrogenase SORD 0.0052
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0052
327 Glutathione reductase gor 0.0052
5110 Glutathione reductase GR2 0.0052
132 ATP-binding cassette sub-family A member 1 ABCA1 0.005
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.005
77 L-lactate dehydrogenase B chain LDHB 0.005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.005
12 Alcohol dehydrogenase class 3 ADH5 0.005
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
6014 Cytochrome P450 2A13 CYP2A13 0.0049
614 Progesterone receptor PGR 0.0049
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0048
2286 Isocitrate dehydrogenase [NADP] icd 0.0048
2302 Isocitrate dehydrogenase [NADP] icd 0.0048
2771 Isocitrate dehydrogenase [NADP] icd 0.0048
4491 DNA ligase, NAD-dependent ligA 0.0048
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0048
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0048
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
473 L-lactate dehydrogenase A chain LDHA 0.0048
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0048
2762 UDP-glucose 4-epimerase GALE 0.0047
3461 UDP-glucose 4-epimerase galE 0.0047
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0047
341 5-hydroxytryptamine 3 receptor HTR3A 0.0046
6212 Tubulin gamma-1 chain TUBG1 0.0045
6210 Tubulin delta chain TUBD1 0.0045
6211 Tubulin epsilon chain TUBE1 0.0045
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0045
569 Retinal dehydrogenase 2 ALDH1A2 0.0045
611 Retinal dehydrogenase 1 ALDH1A1 0.0044
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0044
6106 Cytochrome P450 2C18 CYP2C18 0.0044
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0043
251 Alcohol dehydrogenase 1A ADH1A 0.0043
1313 Lactoylglutathione lyase GLO1 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0042
492 Histamine H1 receptor HRH1 0.0041
444 Alcohol dehydrogenase 1B ADH1B 0.0041
489 Monocarboxylate transporter 2 SLC16A7 0.004
3923 Cholinesterase BCHE 0.004
2981 Phospholipase A2, membrane associated PLA2G2A 0.004
232 Corticosteroid-binding globulin SERPINA6 0.004
320 5-hydroxytryptamine 1A receptor HTR1A 0.004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
714 Glutathione reductase, mitochondrial GSR 0.0039
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0039
3810 Catechol O-methyltransferase COMT 0.0039
5934 Cytochrome P450 26A1 CYP26A1 0.0039
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0038
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0038
4120 NADPH--cytochrome P450 reductase POR 0.0038
1010 Cytochrome P450 51A1 CYP51A1 0.0038
751 Potassium channel subfamily K member 6 KCNK6 0.0038
2539 Tubulin alpha-1 chain TUBA4A 0.0037
273 Apoptosis regulator Bcl-2 BCL2 0.0036
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0036
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0036
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0035
1629 Transcription factor AP-1 JUN 0.0035
4238 50S ribosomal protein L4 rplD 0.0035
5578 50S ribosomal protein L4 rplD 0.0035
6173 50S ribosomal protein L4 rplD 0.0035
6219 50S ribosomal protein L4 rplD 0.0035
172 Potassium channel subfamily K member 1 KCNK1 0.0035
84 Nuclear receptor 0B1 NR0B1 0.0035
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
1517 Beta-3 adrenergic receptor ADRB3 0.0034
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
511 5-hydroxytryptamine 1F receptor HTR1F 0.0033
7 Nitric oxide synthase, inducible NOS2 0.0033
3947 Xanthine dehydrogenase/oxidase XDH 0.0033
2449 Tubulin alpha-3 chain TUBA1A 0.0033
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0033
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0033
817 DNA topoisomerase 2-alpha TOP2A 0.0032
1291 cAMP response element-binding protein CREB1 0.0032
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0032
4237 50S ribosomal protein L22 rplV 0.0032
4210 Toll-like receptor 4 TLR4 0.0032
260 Cytochrome P450 51 ERG11 0.0031
761 Cytochrome P450 51 ERG11 0.0031
3163 Cytochrome P450 51 cyp51 0.0031
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.003
284 DNA-directed RNA polymerase beta chain rpoB 0.003
5773 DNA-directed RNA polymerase beta chain rpoB 0.003
3856 Fibroblast growth factor receptor 3 FGFR3 0.003
4192 DNA topoisomerase 2-beta TOP2B 0.0027
5923 Microtubule-associated protein tau MAPT 0.0027
5924 Microtubule-associated protein 4 MAP4 0.0027
267 Plasminogen activator inhibitor 1 SERPINE1 0.0027
6824 Tyrosine-protein kinase Lyn LYN 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0025
5787 Angiopoietin-1 receptor TEK 0.0025
165 FL cytokine receptor FLT3 0.0024
1630 Integrin beta-2 ITGB2 0.0024
823 Fibroblast growth factor receptor 2 FGFR2 0.0024
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
976 Platelet glycoprotein IX GP9 0.0023
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0023
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0022
6085 Fatty acid-binding protein, intestinal FABP2 0.0022
29 Tubulin beta-1 chain TUBB1 0.0022
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
340 Apoptotic protease-activating factor 1 APAF1 0.0021
504 Mast/stem cell growth factor receptor KIT 0.0021
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.002
6168 Solute carrier family 22 member 16 SLC22A16 0.002
1192 Sulfotransferase 1A1 SULT1A1 0.002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
6044 Serum paraoxonase/lactonase 3 PON3 0.002
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0019
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0019
407 Vascular endothelial growth factor receptor 2 KDR 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0019
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0019
632 Alpha-1B adrenergic receptor ADRA1B 0.0019
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0018
2021 Thrombomodulin THBD 0.0018
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0018
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0018
825 Arsenical pump-driving ATPase ASNA1 0.0018
3435 Arsenical pump-driving ATPase arsA 0.0018
154 AFG3-like protein 2 AFG3L2 0.0018
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0018
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0018
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0018
733 Activin receptor type 1B ACVR1B 0.0018
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0018
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0018
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0018
395 ALK tyrosine kinase receptor Not Available 0.0018
847 Mu-type opioid receptor OPRM1 0.0018
23 D(1A) dopamine receptor DRD1 0.0018
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0018
572 Integrin alpha-L ITGAL 0.0018
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0018
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0018
502 5-hydroxytryptamine 2A receptor HTR2A 0.0017
831 D(2) dopamine receptor DRD2 0.0017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
292 Activin receptor type-1 ACVR1 0.0017
849 Activated CDC42 kinase 1 TNK2 0.0017
556 Alpha-1A adrenergic receptor ADRA1A 0.0016
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0016
4122 Histone deacetylase 2 HDAC2 0.0016
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0016
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0016
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0016
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0016
297 Adenylate cyclase type 1 ADCY1 0.0016
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0016
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0016
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0016
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0016
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0016
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0015
124 Histamine H2 receptor HRH2 0.0015
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0015
484 Tyrosine-protein kinase ABL2 ABL2 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0015
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
5818 Folate receptor alpha FOLR1 0.0013
6220 Aryl hydrocarbon receptor AHR 0.0013
740 Argininosuccinate synthase ASS1 0.0013
865 Argininosuccinate synthase ASS1 0.0013
2680 Argininosuccinate synthase argG 0.0013
3194 Argininosuccinate synthase argG 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
661 ADP/ATP translocase 1 SLC25A4 0.0013
6021 Adenosine kinase ADK 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0013
824 Sodium-dependent serotonin transporter SLC6A4 0.0013
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0012
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
293 Gamma-glutamyl hydrolase GGH 0.0012
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0011
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0011
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0011
1650 Heme carrier protein 1 SLC46A1 0.001
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.001
921 Glutamate receptor 2 GRIA2 0.001
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.001
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.001
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.001
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.001
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0009
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0009
952 Dipeptidyl peptidase 4 DPP4 0.0009
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0009
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
6020 Aldehyde oxidase AOX1 0.0008
24 Thymidylate synthase TMP1 0.0008
359 Thymidylate synthase TYMS 0.0008
2626 Thymidylate synthase thyA 0.0008
2729 Thymidylate synthase thyA 0.0008
5352 Thymidylate synthase THYA 0.0008
365 Dihydrofolate reductase DHFR 0.0007
2381 Dihydrofolate reductase DFR1 0.0007
2833 Dihydrofolate reductase Not Available 0.0007
2931 Dihydrofolate reductase folA 0.0007
3544 Dihydrofolate reductase folA 0.0007
3682 Dihydrofolate reductase folA 0.0007
6642 Dihydrofolate reductase folA 0.0007
6756 Dihydrofolate reductase dfrA 0.0007
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