DT-Web

dTDP-glucose 4,6-dehydratase


Partner ID 4499
Name dTDP-glucose 4,6-dehydratase
Synonyms 5209
Gene name rmlB
General function Involved in dTDP-glucose 4,6-dehydratase activity
Specific function dTDP-glucose = dTDP-4-dehydro-6-deoxy-D- glucose + H(2)O
Gene sequence + ...

ATGACAGAATATAAAAACATTATCGTTACCGGTGGCGCTGGATTCATCGGTTCAAACTTTGTCCACTACGTTTACAATAATCACCCAGATGTCCATGTGACTGTTCTTGACAAACTCACTTACGCTGGTAACCATGCTAACCTTGAAGAAATTCTTGGCGACCGTGTAGAGTTGGTTGTTGGGGACATCGCAGACAGCGAATTGGTAGATAAATTGGCTGCCAAAGCGGATGCTATTGTCCACTATGCGGCTGAAAGCCACAATGACAATTCACTAAAAGATCCATCACCATTTATTTACACTAACTTTGTTGGAACTTATACCTTGTTGGAAGCTGCACGCAAATACGACATCCGTTTCCACCACGTCTCAACTGATGAAGTTTACGGTGATCTTCCGCTACGTGAAGATTTGCCGGGCCACGGTGAAGGTCCGGGTGAAAAATTCACAGCTGAAACGAAATACAATCCATCATCGCCTTATTCATCAACCAAGGCAGCCTCTGACTTGATTGTCAAGGCTTGGGTGCGATCTTTTGGTGTGAAAGCAACCATTTCCAACTGTTCAAACAACTATGGACCTTACCAACACATCGAAAAATTCATTCCGCGCCAAATTACTAACATCCTGTCAGGTATCAAACCAAAACTCTATGGTGAAGGTAAGAACGTGCGTGACTGGATTCACACCAATGACCATTCAACAGGAGTTTGGGCAATTCTCACTAAAGGCCGCATCGGCGAAACTTATCTCATCGGTGCTGATGGTGAAAAGAACAACAAAGAAGTGCTCGAACTTATCCTTGAAAAAATGAGTCAGCCAAAAGACGCATACGACCATGTAACAGACCGTGCAGGTCATGATCTTCGTTATGCCATTGATTCGACAAAGCTGCGTGAGGAACTTGGCTGGAAACCACAATTCACTAATTTTGAAGAAGGCTTGGAAGATACCATTAAATGGTATACTGAGCATGAAGATTGGTGGAAAGCTGAAAAGGAAGCAGTCGAAGCCAACTATGCCAAAACACAAAAAATACTTAATTAA
Protein sequence + ...

MTEYKNIIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNRANLEEILGDRVELVVGDIADSELVDKLAAKADAIVHYAAESHNDNSLKDPSPFIYTNFVGTYILLEAARKYDIRFHHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSTGVWAILTKGRIGETYLIGADGEKNNKEVLELILEKMSQPKNAYDHVTDRAGHDLRYAIDSTKLREELGWKPQFTNFEEGLEDTIKWYTEHEDWWKAEKEAVEANYAKTQKILN
GO Classification
function
carbon-oxygen lyase activity
hydro-lyase activity
NAD binding
binding
dTDP-glucose 4,6-dehydratase activity
catalytic activity
lyase activity
cofactor binding
coenzyme binding
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleotide-sugar metabolism
physiological process
metabolism
cellular metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01907 Nicotinamide-Adenine-Dinucleotide
DB03161 Thymidine-5'-Diphospho-Beta-D-Xylose
DB03751 2'deoxy-Thymidine-5'-Diphospho-Alpha-D-Glucose

Associated as Prediction

Id Name
DB00142 L-Glutamic Acid
DB00143 Glutathione
DB00157 NADH
DB00162 Vitamin A
DB00262 Carmustine
DB00336 Nitrofurazone
DB00435 Nitric Oxide
DB00536 Guanidine
DB00609 Ethionamide
DB00688 Mycophenolate mofetil
DB00727 Nitroglycerin
DB00742 Mannitol
DB00755 Tretinoin
DB00756 Hexachlorophene
DB00822 Disulfiram
DB00898 Ethanol
DB00951 Isoniazid
DB00997 Doxorubicin
DB01024 Mycophenolic acid
DB01213 Fomepizole
DB01536 4-Androstenedione
DB01561 Androstanedione
DB01612 Amyl Nitrite
DB01643 Thymidine-5'-Phosphate
DB01644 3,6-Dihydroxy-Xanthene-9-Propionic Acid
DB01677 Fumarate
DB01691 Indole Naphthyridinone
DB01693 Ribavirin Monophosphate
DB01694 D-tartaric acid
DB01708 Dehydroepiandrosterone
DB01711 2,3,4,5,6-Pentafluorobenzyl Alcohol
DB01713 Udp-Alpha-D-Xylopyranose
DB01727 Isocitric Acid
DB01752 S-Adenosyl-L-Homocysteine
DB01769 Double Oxidized Cysteine
DB01792 Adenylyl-3'-5'-Phospho-Uridine-3'-Monophosphate
DB01848 Isocitrate Calcium Complex
DB01854 5-Bromonicotinamide
DB01861 Glucose-Uridine-C1,5'-Diphosphate
DB01865 3-(6-Aminopyridin-3-Yl)-N-Methyl-N-[(1-Methyl-1h-Indol-2-Yl)Methyl]Acrylamide
DB01907 Nicotinamide-Adenine-Dinucleotide
DB01942 Formic Acid
DB01971 trans-urocanic acid
DB01992 Coenzyme A
DB02007 Alpha-D-Glucose-6-Phosphate
DB02059 Adenosine-5-Diphosphoribose
DB02111 3-Hydroxyisoxazole-4-Carboxylic Acid
DB02115 Daidzin
DB02123 Glycochenodeoxycholic Acid
DB02131 N-1-Methylheptylformamide
DB02147 Cyclo-Tetrametavanadate
DB02153 3-Sulfinoalanine
DB02187 Equilin
DB02190 2-Oxalosuccinic Acid
DB02196 Uridine-Diphosphate-N-Acetylgalactosamine
DB02205 6-(1,1-Dimethylallyl)-2-(1-Hydroxy-1-Methylethyl)-2,3-Dihydro-7h-Furo[3,2-G]Chromen-7-One
DB02212 Pyrophosphate 2-
DB02234 Ethylisothiourea
DB02249 2-Ethoxyethanol
DB02263 Glyceraldehyde-3-Phosphate
DB02323 EM-1745
DB02329 Carbenoxolone
DB02338 Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate
DB02379 Beta-D-Glucose
DB02383 Tolrestat
DB02401 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid
DB02421 Uridine-5'-Diphosphate-Mannose
DB02452 Thymidine-5'-Triphosphate
DB02481 N-Benzylformamide
DB02483 Etheno-Nad
DB02553 Glutathionylspermidine Disulfide
DB02592 Carbaphosphonate
DB02596 Alpha,Beta-Methyleneadenosine-5'-Triphosphate
DB02621 Latrunculin A
DB02637 Oxaloacetate Ion
DB02659 Cholic Acid
DB02701 Nicotinamide
DB02721 4-Iodopyrazole
DB02757 Pyrazole
DB02772 Sucrose
DB02790 Phenyl-Uridine-5'-Diphosphate
DB02820 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
DB02822 Para-Bromobenzyl Alcohol
DB02843 Alpha-D-Glucose-1-Phosphate
DB02854 Aetiocholanolone
DB02871 3-Butylthiolane 1-Oxide
DB02895 3-(Prop-2-Ene-1-Sulfinyl)-Propene-1-Thiol
DB02901 Dihydrotestosterone
DB02937 Gamma-Arsono-Beta, Gamma-Methyleneadenosine-5'-Diphosphate
DB02990 C16-Fatty-Acyl-Substrate-Mimic
DB03014 Heme
DB03020 5-Beta-D-Ribofuranosylnicotinamide Adenine Dinucleotide
DB03030 4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole
DB03041 Udp-Glucuronic Acid
DB03059 Acetoacetyl-Coenzyme A
DB03061 (R)-N-(1-Methyl-Hexyl)-Formamide
DB03070 Selenazole-4-Carboxyamide-Adenine Dinucleotide
DB03095 Tetramethylammonium Ion
DB03147 Flavin-Adenine Dinucleotide
DB03161 Thymidine-5'-Diphospho-Beta-D-Xylose
DB03162 4-Hydroxy-1,2,5-Thiadiazole-3-Carboxylic Acid
DB03169 (S)-Hmg-Coa
DB03192 3r-Hydroxydecanoyl-Coa
DB03211 (3-Formyl-but-3-Enyl)-Phosphonic Acid
DB03216 (1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)Adenine
DB03226 Trifluoroethanol
DB03227 Nicotinamide Mononucleotide
DB03229 2-Oxo-4-Methylpentanoic Acid
DB03247 Riboflavin Monophosphate
DB03273 3'-Oxo-Adenosine
DB03310 Oxidized Glutathione Disulfide
DB03323 Maltose
DB03331 N-Naphthalen-1-Ylmethyl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine
DB03345 Beta-Mercaptoethanol
DB03382 S-Oxy Cysteine
DB03397 Uridine-Diphosphate-N-Acetylglucosamine
DB03431 Adenosine-5'-Diphosphate
DB03435 Uridine-5'-Diphosphate
DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose
DB03478 2'-O-Acetyl Adenosine-5-Diphosphoribose
DB03499 Malate Ion
DB03501 Uridine Diphosphate Galactose
DB03518 (R)-Mevalonate
DB03534 3-[(Acetyl-Methyl-Amino)-Methyl]-4-Amino-N-Methyl-N-(1-Methyl-1h-Indol-2-Ylmethyl)-Benzamide
DB03559 Cyclohexylformamide
DB03589 Alpha-Ketomalonic Acid
DB03612 3-Hydroxybutyryl-Coenzyme A
DB03639 1-Guanidinium-7-Aminoheptane
DB03680 Tartronate
DB03703 Cyclohexanol
DB03704 12-Hydroxydodecanoic Acid
DB03723 2'-Deoxy-Thymidine-Beta-L-Rhamnose
DB03751 2'deoxy-Thymidine-5'-Diphospho-Alpha-D-Glucose
DB03769 D-Eritadenine
DB03785 (3r,5r)-7-((1r,2r,6s,8r,8as)-2,6-Dimethyl-8-{[(2r)-2-Methylbutanoyl]Oxy}-1,2,6,7,8,8a-Hexahydronaphthalen-1-Yl)-3,5-Dihydroxyheptanoic Acid
DB03811 Histidinol
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03867 Meta-Nitro-Tyrosine
DB03893 Thionicotinamide-Adenine-Dinucleotide
DB03940 Oxamic Acid
DB03948 6-Chloropurine Riboside, 5'-Monophosphate
DB03969 3-Acetyl Pyridine Adenine Dinucleotide
DB04023 Guanosine 5'-(Trihydrogen Diphosphate), P'-D-Mannopyranosyl Ester
DB04030 1,3,4,9-Tetrahydro-2-(Hydroxybenzoyl)-9-[(4-Hydroxyphenyl)Methyl]-6-Methoxy-2h-Pyrido[3,4-B]Indole
DB04065 N-Cyclopentyl-N-Cyclobutylformamide
DB04071 Cpad
DB04077 Glycerol
DB04097 Uridine-5'-Diphosphate-4-Deoxy-4-Fluoro-Alpha-D-Galactose
DB04099 Deamido-Nad+
DB04105 N-Heptylformamide
DB04113 N-Formylpiperidine
DB04122 Beta-D-Glucose-6-Phosphate
DB04137 Guanosine-5'-Triphosphate
DB04153 S-Hydroxymethyl Glutathione
DB04160 Diphosphate
DB04200 Matairesinol
DB04267 Dipicolinic Acid
DB04272 Citric Acid
DB04279 3-Isopropylmalic Acid
DB04289 Genz-10850
DB04312 2,3-Difluorobenzyl Alcohol
DB04355 Uridine-5'-Monophosphate Glucopyranosyl-Monophosphateester
DB04381 Crotonaldehyde
DB04393 Diclosan
DB04401 [Formylmethyl]Trimethyl-Ammonium, N,N,N-Trimethylammonium Acetaldehyde
DB04447 1,4-Dithiothreitol
DB04448 2,4-Difluorobenzyl Alcohol 2,4-Difluoro-1-(Hydroxymethyl)Benzene
DB04477 N-1,2,3,4-Tetrahydronaphth-1-Yl-2'-[3,5-Dimethoxybenzamido]-2'-Deoxy-Adenosine
DB04478 Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
DB04485 Deoxythymidine
DB04522 Phosphonoserine
DB04555 Cytidine-5'-Diphosphate
DB04566 Inosinic Acid
DB04640 Naphthalene-2,6-disulfonic acid
DB04641 3,7-DIHYDROXYNAPHTHALENE-2-CARBOXYLIC ACID
DB04786 Suramin
DB06770 Benzyl alcohol
DB07040 2-amino-7-fluoro-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide
DB07041 N-[2-(2,4-diaminopyrido[2,3-d]pyrimidin-7-yl)-2-methylpropyl]-4-phenoxybenzamide
DB07042 7-amino-2-tert-butyl-4-{[2-(1H-imidazol-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidine-6-carboxamide
DB07043 7-amino-2-tert-butyl-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrido[2,3-d]pyrimidine-6-carboxamide
DB07090 (3S)-N-(3-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07123 N-(4-METHYLBENZOYL)-4-BENZYLPIPERIDINE
DB07155 (3S)-1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE
DB07178 5-PENTYL-2-PHENOXYPHENOL
DB07188 (3S)-1-CYCLOHEXYL-N-(3,5-DICHLOROPHENYL)-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07192 (3S)-N-(3-BROMOPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07222 (3S)-N-(5-CHLORO-2-METHYLPHENYL)-1-CYCLOHEXYL-5-OXOPYRROLIDINE-3-CARBOXAMIDE
DB07287 2-(2,4-DICHLOROPHENOXY)-5-(PYRIDIN-2-YLMETHYL)PHENOL
DB07347 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
DB07393 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE
DB07714 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID
DB08265 2-(TOLUENE-4-SULFONYL)-2H-BENZO[D][1,2,3]DIAZABORININ-1-OL
DB08604 TRICLOSAN
DB08605 6-METHYL-2(PROPANE-1-SULFONYL)-2H-THIENO[3,2-D][1,2,3]DIAZABORININ-1-OL
↑