DT-Web: DB00688

Identification

Name

Mycophenolate mofetil

Accession Number

DB00688 (APRD01602)

Type

small molecule

Description

Mycophenolate mofetil is the 2-morpholinoethyl ester of mycophenolic acid (MPA), an immunosuppressive agent, inosine monophosphate dehydrogenase (IMPDH) inhibitor.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

433.4947

Groups

approved

Monoisotopic Weight

433.210052351

Pharmacology

Indication

For the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. Mycophenolate mofetil should be used concomitantly with cyclosporine and corticosteroids.

Mechanism of action

Mycophenolate mofetil is hydrolyzed to form mycophenolic acid (MPA), which is the active metabolite. MPA is a potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH), and therefore inhibits the de novo pathway of guanosine nucleotide synthesis without incorporation into DNA. Because T- and B-lymphocytes are critically dependent for their proliferation on de novo synthesis of purines, whereas other cell types can utilize salvage pathways, MPA has potent cytostatic effects on lymphocytes. MPA inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic effects of MPA on lymphocytes. MPA also suppresses antibody formation by B-lymphocytes. MPA prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection. Mycophenolate mofetil did not inhibit early events in the activation of human peripheral blood mononuclear cells, such as the production of interleukin-1 (IL-1) and interleukin-2 (IL-2), but did block the coupling of these events to DNA synthesis and proliferation.

Absorption

Rapidly absorbed following oral administration. In 12 healthy volunteers, the mean absolute bioavailability of oral mycophenolate mofetil relative to intravenous mycophenolate mofetil (based on MPA AUC) was 94%. The absolute bioavailability of the delayed release tablet in stable renal transplant patients on cyclosporin is 72%. Food (27 g fat, 650 calories) has no effect on the extent of absorption (MPA AUC) of mycophenolate mofetil.

Protein binding

MPA (the active metabolite), at clinically relevant concentrations, is over 98% bound to plasma albumin. The phenolic glucuronide of MPA, mycophenolic acid glucuronide (MPAG) has 82% protein bound.

Biotransformation

Following oral and intravenous dosing, mycophenolate mofetil undergoes complete metabolism to MPA, the active metabolite. Metabolism to MPA occurs presystemically after oral dosing. MPA is metabolized principally by glucuronyl transferase to form the phenolic glucuronide of MPA (MPAG) which is not pharmacologically active. In vivo, MPAG is converted to MPA via enterohepatic recirculation. The following metabolites of the 2-hydroxyethyl-morpholino moiety are also recovered in the urine following oral administration of mycophenolate mofetil to healthy subjects: N-(2-carboxymethyl)-morpholine, N-(2-hydroxyethyl)-morpholine, and the N-oxide of N-(2-hydroxyethyl)-morpholine. Cytochrome P450 isozymes, CYP3A4/5 and to a lesser extent by CYP2C8, is responsible for the biotransformation of MPA to 6-O-desmethyl-mycophenolic acid.

Route of elimination

Negligible amount of drug is excreted as MPA (< 1% of dose) in the urine. When orally administered, mycophenolate mofetil was completely recovered with 93% of the dose found in the urine and 6% found in feces. 87% of the administered dose is excreted in the urine as MPAG.

Toxicity

Oral (LD50): Acute: 352 mg/kg [Rat], 1000 mg/kg [Mouse], and >6000 mg/kg [Rabbit]. Possible signs and symptoms of acute overdose could include the following: hematological abnormalities such as leukopenia and neutropenia, and gastrointestinal symptoms such as abdominal pain, diarrhea, nausea and vomiting, and dyspepsia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Belatacept	Belatacept increases the Cmax and AUC of mycophenolate mofetil.
Calcium	Formation of non-absorbable complexes
Iron	Oral iron decreases the absorption of mycophenolate-mofetil
Iron Dextran	Oral iron decreases the absorption of mycophenolate-mofetil
Rifampin	Rifampin may decrease the serum concentration of mycophenolate. Concomitant therapy should be avoided.
Rilonacept	results in increased immunosuppressive effects; increases the risk of infection.
Tacrolimus	Tacrolimus may increase the plasma concentration of Mycophenolic acid. Monitor and adjust the dose of Mycophenolate mofetil to the therapeutic range.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Valganciclovir	The excretion rates of Valganciclovir and/or Mycophenolate mofetil may decrease. Monitor for increased serum concentrations and toxicity of both agents.

Food Interactions

Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
Take on empty stomach: 1 hour before or 2 hours after meals.

Inosine-5'-monophosphate dehydrogenase 1
Name	Inosine-5'-monophosphate dehydrogenase 1
Gene Name	IMPDH1
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Bremer S, Rootwelt H, Bergan S: Real-time PCR determination of IMPDH1 and IMPDH2 expression in blood cells. Clin Chem. 2007 Jun;53(6):1023-9. Epub 2007 Apr 26. - Pubmed Wang J, Yang JW, Zeevi A, Webber SA, Girnita DM, Selby R, Fu J, Shah T, Pravica V, Hutchinson IV, Burckart GJ: IMPDH1 Gene Polymorphisms and Association With Acute Rejection in Renal Transplant Patients. Clin Pharmacol Ther. 2007 Sep 12;. - Pubmed Sanquer S, Maison P, Tomkiewicz C, Macquin-Mavier I, Legendre C, Barouki R, Lang P: Expression of Inosine Monophosphate Dehydrogenase Type I and Type II After Mycophenolate Mofetil Treatment: A 2-year Follow-up in Kidney Transplantation. Clin Pharmacol Ther. 2007 Aug 22;. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	Not Available
Inosine-5'-monophosphate dehydrogenase 2
Name	Inosine-5'-monophosphate dehydrogenase 2
Gene Name	IMPDH2
Pharmacological action	yes
Actions	inhibitor
References	Vannozzi F, Filipponi F, Di Paolo A, Danesi R, Urbani L, Bocci G, Catalano G, De Simone P, Mosca F, Del Tacca M: An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. Transplant Proc. 2004 Nov;36(9):2787-90. - Pubmed Bremer S, Rootwelt H, Bergan S: Real-time PCR determination of IMPDH1 and IMPDH2 expression in blood cells. Clin Chem. 2007 Jun;53(6):1023-9. Epub 2007 Apr 26. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	Not Available

UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate
References	Miles KK, Kessler FK, Smith PC, Ritter JK: Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9. Epub 2006 Jun 21. - Pubmed
DTHybrid score	0.4551
UDP-glucuronosyltransferase 1-7
Name	UDP-glucuronosyltransferase 1-7
Gene Name	Not Available
Actions	substrate
References	Miles KK, Kessler FK, Smith PC, Ritter JK: Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9. Epub 2006 Jun 21. - Pubmed
DTHybrid score	Not Available
UDP-glucuronosyltransferase 1-6
Name	UDP-glucuronosyltransferase 1-6
Gene Name	Not Available
Actions	substrate
References	Miles KK, Kessler FK, Smith PC, Ritter JK: Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9. Epub 2006 Jun 21. - Pubmed
DTHybrid score	Not Available
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Picard N, Ratanasavanh D, Premaud A, Le Meur Y, Marquet P: Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism. Drug Metab Dispos. 2005 Jan;33(1):139-46. Epub 2004 Oct 6. - Pubmed
DTHybrid score	0.4795
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	Picard N, Ratanasavanh D, Premaud A, Le Meur Y, Marquet P: Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism. Drug Metab Dispos. 2005 Jan;33(1):139-46. Epub 2004 Oct 6. - Pubmed
DTHybrid score	0.4355
UDP-glucuronosyltransferase 1-8
Name	UDP-glucuronosyltransferase 1-8
Gene Name	UGT1A8
Actions	substrate
References	Thervet E, Anglicheau D, Legendre C: [Pharmacology of mycophenolate mofetil: recent data and clinical consequences]. Nephrologie. 2001;22(7):331-7. - Pubmed
DTHybrid score	0.2222
UDP-glucuronosyltransferase 1-10
Name	UDP-glucuronosyltransferase 1-10
Gene Name	UGT1A10
Actions	substrate
References	Thervet E, Anglicheau D, Legendre C: [Pharmacology of mycophenolate mofetil: recent data and clinical consequences]. Nephrologie. 2001;22(7):331-7. - Pubmed
DTHybrid score	0.2123
Liver carboxylesterase 1
Name	Liver carboxylesterase 1
Gene Name	CES1
Actions	substrate
References	Fujiyama N, Miura M, Kato S, Sone T, Isobe M, Satoh S: Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetil. Drug Metab Dispos. 2010 Dec;38(12):2210-7. doi: 10.1124/dmd.110.034249. Epub 2010 Sep 7. - Pubmed
DTHybrid score	0.6112
Cocaine esterase
Name	Cocaine esterase
Gene Name	Not Available
Actions	Not Available
References	Fujiyama N, Miura M, Kato S, Sone T, Isobe M, Satoh S: Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetil. Drug Metab Dispos. 2010 Dec;38(12):2210-7. doi: 10.1124/dmd.110.034249. Epub 2010 Sep 7. - Pubmed
DTHybrid score	Not Available
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Picard N, Cresteil T, Premaud A, Marquet P: Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5. Ther Drug Monit. 2004 Dec;26(6):600-8. - Pubmed
DTHybrid score	0.7859
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Picard N, Cresteil T, Premaud A, Marquet P: Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5. Ther Drug Monit. 2004 Dec;26(6):600-8. - Pubmed
DTHybrid score	0.4562
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Picard N, Cresteil T, Premaud A, Marquet P: Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5. Ther Drug Monit. 2004 Dec;26(6):600-8. - Pubmed
DTHybrid score	0.4848

Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate
References	Miura M, Satoh S, Inoue K, Kagaya H, Saito M, Inoue T, Suzuki T, Habuchi T: Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. Epub 2007 Sep 29. - Pubmed
DTHybrid score	0.4594
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate
References	Michelon H, Konig J, Durrbach A, Quteineh L, Verstuyft C, Furlan V, Ferlicot S, Letierce A, Charpentier B, Fromm MF, Becquemont L: SLCO1B1 genetic polymorphism influences mycophenolic acid tolerance in renal transplant recipients. Pharmacogenomics. 2010 Dec;11(12):1703-13. doi: 10.2217/pgs.10.132. - Pubmed Miura M, Satoh S, Inoue K, Kagaya H, Saito M, Inoue T, Suzuki T, Habuchi T: Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. Epub 2007 Sep 29. - Pubmed
DTHybrid score	0.3155
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Miura M, Satoh S, Inoue K, Kagaya H, Saito M, Inoue T, Suzuki T, Habuchi T: Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9. Epub 2007 Sep 29. - Pubmed
DTHybrid score	0.3627
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Miura M, Kagaya H, Satoh S, Inoue K, Saito M, Habuchi T, Suzuki T: Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. doi: 10.1097/FTD.0b013e3181838063. - Pubmed
DTHybrid score	0.3796
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Miura M, Kagaya H, Satoh S, Inoue K, Saito M, Habuchi T, Suzuki T: Influence of drug transporters and UGT polymorphisms on pharmacokinetics of phenolic glucuronide metabolite of mycophenolic acid in Japanese renal transplant recipients. Ther Drug Monit. 2008 Oct;30(5):559-64. doi: 10.1097/FTD.0b013e3181838063. - Pubmed
DTHybrid score	0.675

Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions
References	Not Available
DTHybrid score	0.4594
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions
References	Not Available
DTHybrid score	0.3155
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.3627
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.3796
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.675

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.4515
6016	Cytochrome P450 2C19	CYP2C19	0.3376
4119	Cytochrome P450 2D6	CYP2D6	0.3031
4200	Cytochrome P450 1A2	CYP1A2	0.2865
6107	Cytochrome P450 3A7	CYP3A7	0.2596
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.2255
6030	Cytochrome P450 2B6	CYP2B6	0.2126
20	Prostaglandin G/H synthase 1	PTGS1	0.202
1729	Solute carrier family 22 member 6	SLC22A6	0.1908
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1899
862	Multidrug resistance-associated protein 1	ABCC1	0.161
290	Prostaglandin G/H synthase 2	PTGS2	0.1474
6024	Cytochrome P450 1A1	CYP1A1	0.146
6013	Cytochrome P450 2E1	CYP2E1	0.1303
2297	Genome polyprotein	Not Available	0.1215
2322	Genome polyprotein	Not Available	0.1215
2694	Genome polyprotein	Not Available	0.1215
2719	Genome polyprotein	Not Available	0.1215
2860	Genome polyprotein	Not Available	0.1215
2928	Genome polyprotein	Not Available	0.1215
3160	Genome polyprotein	Not Available	0.1215
3260	Genome polyprotein	Not Available	0.1215
4783	Genome polyprotein	Not Available	0.1215
5726	Genome polyprotein	Not Available	0.1215
5779	Genome polyprotein	Not Available	0.1215
5867	Genome polyprotein	Not Available	0.1215
6253	Genome polyprotein	Not Available	0.1215
6301	Genome polyprotein	Not Available	0.1215
6380	Genome polyprotein	Not Available	0.1215
6381	Genome polyprotein	Not Available	0.1215
6437	Genome polyprotein	Not Available	0.1215
6520	Genome polyprotein	Not Available	0.1215
6521	Genome polyprotein	Not Available	0.1215
6652	Genome polyprotein	Not Available	0.1215
6734	Genome polyprotein	Not Available	0.1215
6735	Genome polyprotein	Not Available	0.1215
6736	Genome polyprotein	Not Available	0.1215
6737	Genome polyprotein	Not Available	0.1215
6738	Genome polyprotein	Not Available	0.1215
6739	Genome polyprotein	Not Available	0.1215
6744	Genome polyprotein	Not Available	0.1215
6748	Genome polyprotein	Not Available	0.1215
6894	Genome polyprotein	Not Available	0.1215
6898	Genome polyprotein	Not Available	0.1215
6142	Solute carrier family 22 member 8	SLC22A8	0.1194
2164	Multidrug resistance-associated protein 4	ABCC4	0.1192
5718	Cytochrome P450 2A6	CYP2A6	0.1092
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.1058
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.1058
776	Bile salt export pump	ABCB11	0.1057
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1021
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0986
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0986
70	Type-1 angiotensin II receptor	AGTR1	0.0812
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0787
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0774
6145	Solute carrier family 22 member 1	SLC22A1	0.0752
1898	Cytochrome P450 1B1	CYP1B1	0.0747
6143	Solute carrier family 22 member 7	SLC22A7	0.0742
6106	Cytochrome P450 2C18	CYP2C18	0.0727
847	Mu-type opioid receptor	OPRM1	0.067
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0648
467	Delta-type opioid receptor	OPRD1	0.0637
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0636
6141	Sodium/bile acid cotransporter	SLC10A1	0.0632
1024	Solute carrier family 22 member 11	SLC22A11	0.0626
696	Kappa-type opioid receptor	OPRK1	0.0623
3811	Cytochrome P450 19A1	CYP19A1	0.0572
118	Organic cation/carnitine transporter 2	SLC22A5	0.0552
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0548
6148	Multidrug resistance-associated protein 7	ABCC10	0.0525
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0502
6144	Solute carrier family 22 member 2	SLC22A2	0.0493
871	Glucocorticoid receptor	NR3C1	0.0492
738	Monocarboxylate transporter 1	SLC16A1	0.0492
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0491
136	Estrogen receptor	ESR1	0.0491
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0478
373	Transthyretin	TTR	0.0476
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.046
817	DNA topoisomerase 2-alpha	TOP2A	0.0447
3810	Catechol O-methyltransferase	COMT	0.0427
311	RNA-directed RNA polymerase catalytic subunit	PB1	0.0426
752	Large structural protein	L	0.0426
504	Mast/stem cell growth factor receptor	KIT	0.0415
26	Vascular endothelial growth factor receptor 3	FLT4	0.0411
6137	Multidrug resistance-associated protein 6	ABCC6	0.0403
492	Histamine H1 receptor	HRH1	0.04
3587	Gastrotropin	FABP6	0.0395
6102	Arylamine N-acetyltransferase 2	NAT2	0.0394
824	Sodium-dependent serotonin transporter	SLC6A4	0.0393
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0393
32	Vascular endothelial growth factor receptor 1	FLT1	0.0393
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0389
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0382
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0379
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0365
6147	Solute carrier family 22 member 3	SLC22A3	0.0358
844	Epidermal growth factor receptor	EGFR	0.0357
731	HIV-1 protease	HIV-1 protease	0.0354
3719	Inosine-5'-monophosphate dehydrogenase	guaB	0.0353
3799	Hypoxanthine phosphoribosyltransferase	hpt	0.0353
407	Vascular endothelial growth factor receptor 2	KDR	0.0351
556	Alpha-1A adrenergic receptor	ADRA1A	0.035
29	Tubulin beta-1 chain	TUBB1	0.0349
6606	Platelet-activating factor acetylhydrolase IB subunit gamma	PAFAH1B3	0.0348
4175	Platelet-activating factor acetylhydrolase	PLA2G7	0.0348
1353	DNA topoisomerase 1	TOP1	0.0345
3552	DNA topoisomerase 1	topA	0.0345
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0342
508	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	0.0341
267	Plasminogen activator inhibitor 1	SERPINE1	0.0341
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.034
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0335
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0334
3809	Estrogen-related receptor gamma	ESRRG	0.0333
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0326
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0325
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0325
831	D(2) dopamine receptor	DRD2	0.0322
6031	Cytochrome P450 3A43	CYP3A43	0.032
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0319
6136	Multidrug resistance-associated protein 5	ABCC5	0.0318
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0315
6221	Steroid hormone receptor ERR1	ESRRA	0.031
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0309
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0308
6021	Adenosine kinase	ADK	0.0308
6171	Solute carrier family 28 member 3	SLC28A3	0.0306
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0303
459	Retinoic acid receptor RXR-alpha	RXRA	0.0302
6026	Alcohol dehydrogenase 6	ADH6	0.03
891	Dihydropteroate synthase	folP	0.0299
5359	Dihydropteroate synthase	folP	0.0299
7175	Dihydropteroate synthase	sulI	0.0299
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0294
468	Cytochrome P450 4A11	CYP4A11	0.0292
1192	Sulfotransferase 1A1	SULT1A1	0.0292
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0292
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0289
275	Arachidonate 5-lipoxygenase	ALOX5	0.0287
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0283
146	Androgen receptor	AR	0.0283
1039	Histone deacetylase 9	HDAC9	0.028
3923	Cholinesterase	BCHE	0.0272
632	Alpha-1B adrenergic receptor	ADRA1B	0.0268
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0266
758	Thyroid hormone receptor alpha	THRA	0.0265
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0261
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.026
117	Sterol O-acyltransferase 1	SOAT1	0.0258
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0257
833	Organic cation/carnitine transporter 1	SLC22A4	0.0256
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0256
4269	Hypoxanthine-guanine phosphoribosyltransferase, putative	HGPRTase	0.0253
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0252
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0248
614	Progesterone receptor	PGR	0.0244
594	Thyroxine-binding globulin	SERPINA7	0.0243
2539	Tubulin alpha-1 chain	TUBA4A	0.024
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0239
24	Thymidylate synthase	TMP1	0.0239
359	Thymidylate synthase	TYMS	0.0239
2626	Thymidylate synthase	thyA	0.0239
2729	Thymidylate synthase	thyA	0.0239
5352	Thymidylate synthase	THYA	0.0239
6085	Fatty acid-binding protein, intestinal	FABP2	0.0239
346	Thyroid hormone receptor beta-1	THRB	0.0237
273	Apoptosis regulator Bcl-2	BCL2	0.0236
33	Cystine/glutamate transporter	SLC7A11	0.0234
5880	Thrombopoietin receptor	MPL	0.0234
766	Beta-2 adrenergic receptor	ADRB2	0.0233
756	Sex hormone-binding globulin	SHBG	0.0233
232	Corticosteroid-binding globulin	SERPINA6	0.0232
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.023
23	D(1A) dopamine receptor	DRD1	0.023
3978	Adenylosuccinate synthetase isozyme 1	ADSSL1	0.0229
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0227
54	Prothrombin	F2	0.0224
723	Cytosolic phospholipase A2	PLA2G4A	0.0224
6182	Cytochrome P450 2J2	CYP2J2	0.0222
869	Estrogen receptor beta	ESR2	0.0221
2632	Adenylosuccinate synthetase	purA	0.022
3323	Adenylosuccinate synthetase	purA	0.022
3975	Adenylosuccinate synthetase	ADSS	0.022
4598	Adenylosuccinate synthetase	Adss	0.022
6817	Adenylosuccinate synthetase	purA	0.022
890	Niemann-Pick C1-like protein 1	NPC1L1	0.022
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.022
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0219
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0217
1757	Myeloperoxidase	MPO	0.0216
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0213
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0212
1050	Bile salt sulfotransferase	SULT2A1	0.021
244	Angiotensin-converting enzyme	ACE	0.0209
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0207
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0204
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0204
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0204
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0202
6167	Organic solute transporter subunit beta	OSTB	0.0202
6166	Organic solute transporter subunit alpha	OSTA	0.0202
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0202
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0201
6220	Aryl hydrocarbon receptor	AHR	0.02
789	Alpha-1D adrenergic receptor	ADRA1D	0.02
122	P2Y purinoceptor 12	P2RY12	0.0199
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0196
1760	Aminopeptidase N	ANPEP	0.0196
6843	Aminopeptidase N	pepN	0.0196
3947	Xanthine dehydrogenase/oxidase	XDH	0.0195
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0195
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0194
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0193
477	DNA topoisomerase 4 subunit A	parC	0.0191
886	DNA topoisomerase 4 subunit A	parC	0.0191
6226	DNA topoisomerase 4 subunit A	parC	0.0191
1852	Microtubule-associated protein 2	MAP2	0.0191
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.019
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.019
952	Dipeptidyl peptidase 4	DPP4	0.0189
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0189
404	DNA gyrase subunit A	gyrA	0.0188
6224	DNA gyrase subunit A	gyrA	0.0188
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0188
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0186
318	Alpha-2A adrenergic receptor	ADRA2A	0.0185
13	Aminomethyltransferase, mitochondrial	AMT	0.0185
811	Translocator protein	TSPO	0.0184
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.018
2178	Metabotropic glutamate receptor 5	GRM5	0.018
5923	Microtubule-associated protein tau	MAPT	0.018
5924	Microtubule-associated protein 4	MAP4	0.018
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.018
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0179
260	Cytochrome P450 51	ERG11	0.0178
761	Cytochrome P450 51	ERG11	0.0178
3163	Cytochrome P450 51	cyp51	0.0178
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0177
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0176
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0174
165	FL cytokine receptor	FLT3	0.0173
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0171
3233	Bile acid receptor	NR1H4	0.0171
1152	Glycogen phosphorylase, muscle form	PYGM	0.017
1275	Estrogen sulfotransferase	SULT1E1	0.0169
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0169
1389	Transforming growth factor beta-1	TGFB1	0.0169
4120	NADPH--cytochrome P450 reductase	POR	0.0168
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0167
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0164
3866	Serum amyloid A protein	SAA1	0.0163
1200	AMBP protein	AMBP	0.0163
1932	Apolipoprotein E	APOE	0.0163
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0162
737	Mineralocorticoid receptor	NR3C2	0.0162
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0161
6043	Putative G-protein coupled receptor 44	GPR44	0.016
638	D(3) dopamine receptor	DRD3	0.0159
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0156
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0156
908	Glutathione S-transferase theta-1	GSTT1	0.0155
3937	Fatty-acid amide hydrolase	FAAH	0.0154
1630	Integrin beta-2	ITGB2	0.0153
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0153
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0152
904	Glutathione S-transferase P	GSTP1	0.0152
5787	Angiopoietin-1 receptor	TEK	0.0152
6138	Multidrug resistance protein 3	ABCB4	0.015
193	Beta-1 adrenergic receptor	ADRB1	0.015
380	Cytochrome P450 17A1	CYP17A1	0.015
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0148
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0145
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0145
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0144
319	Opioid receptor, sigma 1	OPRS1	0.0144
161	Tubulin beta chain	TUBB	0.0144
312	Tubulin beta chain	TUB2	0.0144
3941	Amine oxidase [flavin-containing] A	MAOA	0.0144
199	Monocarboxylate transporter 8	SLC16A2	0.0144
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0142
3856	Fibroblast growth factor receptor 3	FGFR3	0.0141
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0141
465	Calmodulin	CALM1	0.0141
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0138
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0138
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0138
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0135
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0135
1650	Heme carrier protein 1	SLC46A1	0.0134
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0133
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0131
713	Sodium-dependent dopamine transporter	SLC6A3	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
6020	Aldehyde oxidase	AOX1	0.0129
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
3639	Thymidine phosphorylase	deoA	0.0128
3936	Thymidine phosphorylase	TYMP	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
705	Glutamate receptor 1	GRIA1	0.0128
6500	Phospholipase A2	PLA2G1B	0.0125
6044	Serum paraoxonase/lactonase 3	PON3	0.0124
6042	Prostaglandin reductase 2	PTGR2	0.0124
4122	Histone deacetylase 2	HDAC2	0.0123
6103	Arylamine N-acetyltransferase 1	NAT1	0.0123
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0122
3611	Cytidine deaminase	cdd	0.0121
3707	Cytidine deaminase	cdd	0.0121
4211	Cytidine deaminase	CDA	0.0121
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0121
777	Tumor necrosis factor	TNF	0.012
4773	Deoxycytidine kinase	DCK	0.012
1141	Sialidase-1	NEU1	0.012
64	Neuraminidase	NA	0.012
641	Neuraminidase	NA	0.012
2676	Neuraminidase	NA	0.012
3026	Neuraminidase	NA	0.012
3519	Neuraminidase	NA	0.012
6007	Neuraminidase	NA	0.012
1618	High affinity nerve growth factor receptor	NTRK1	0.0118
2021	Thrombomodulin	THBD	0.0117
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0117
489	Monocarboxylate transporter 2	SLC16A7	0.0116
768	FK506-binding protein 1A	FKBP1A	0.0116
365	Dihydrofolate reductase	DHFR	0.0115
2381	Dihydrofolate reductase	DFR1	0.0115
2833	Dihydrofolate reductase	Not Available	0.0115
2931	Dihydrofolate reductase	folA	0.0115
3544	Dihydrofolate reductase	folA	0.0115
3682	Dihydrofolate reductase	folA	0.0115
6642	Dihydrofolate reductase	folA	0.0115
6756	Dihydrofolate reductase	dfrA	0.0115
572	Integrin alpha-L	ITGAL	0.0115
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0115
4192	DNA topoisomerase 2-beta	TOP2B	0.0115
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0114
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0114
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0114
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0114
2211	Fatty acid-binding protein, heart	FABP3	0.0114
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0114
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0113
6149	Solute carrier family 22 member 10	SLC22A10	0.0113
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0113
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0113
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
823	Fibroblast growth factor receptor 2	FGFR2	0.0112
629	Alpha-2B adrenergic receptor	ADRA2B	0.0111
2443	Azurin	azu	0.0108
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0107
378	Alpha-2C adrenergic receptor	ADRA2C	0.0106
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0105
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0104
284	DNA-directed RNA polymerase beta chain	rpoB	0.0104
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0104
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0104
6168	Solute carrier family 22 member 16	SLC22A16	0.0103
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0103
5482	Sialidase-2	NEU2	0.0102
1313	Lactoylglutathione lyase	GLO1	0.0101
936	Ephrin type-A receptor 2	EPHA2	0.0101
818	50S ribosomal protein L10	rplJ	0.0101
6146	High affinity copper uptake protein 1	SLC31A1	0.01
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0099
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0097
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0096
6151	Monocarboxylate transporter 10	SLC16A10	0.0096
566	Serotransferrin	TF	0.0094
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0094
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0094
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0093
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0093
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0092
2808	Chloramphenicol acetyltransferase 3	cat3	0.0092
469	Annexin A1	ANXA1	0.0092
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0092
6163	Copper-transporting ATPase 2	ATP7B	0.0091
6165	Copper-transporting ATPase 1	ATP7A	0.0091
5798	Mitogen-activated protein kinase 11	MAPK11	0.0091
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.009
183	Vascular endothelial growth factor A	VEGFA	0.009
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0089
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0088
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0088
3932	Glutathione S-transferase A2	GSTA2	0.0088
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0088
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0088
4217	Telomerase reverse transcriptase	TERT	0.0088
896	Glutathione S-transferase Mu 1	GSTM1	0.0087
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0087
461	Glycine receptor subunit alpha-3	GLRA3	0.0086
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0085
1629	Transcription factor AP-1	JUN	0.0085
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0084
293	Gamma-glutamyl hydrolase	GGH	0.0084
2391	Ferrochelatase	hemH	0.0084
6502	Ferrochelatase	DKFZp686P18130	0.0084
1591	Ferrochelatase, mitochondrial	FECH	0.0084
239	Coagulation factor X	F10	0.0084
1525	Heparin-binding growth factor 2	FGF2	0.0084
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0083
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0083
124	Histamine H2 receptor	HRH2	0.0083
6501	Fatty acid-binding protein, liver	FABP1	0.0083
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0082
551	Carnitine O-acetyltransferase	CRAT	0.0082
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0082
558	Solute carrier family 12 member 1	SLC12A1	0.0082
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
1792	Tissue-type plasminogen activator	PLAT	0.0081
517	Alcohol dehydrogenase 1C	ADH1C	0.0081
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0081
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
4476	Mannitol dehydrogenase	mtlD	0.0079
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0078
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0078
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0078
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0077
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0077
4237	50S ribosomal protein L22	rplV	0.0076
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0076
992	Protein tyrosine kinase 2 beta	PTK2B	0.0076
5300	Antigen peptide transporter 1	TAP1	0.0075
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
432	D(4) dopamine receptor	DRD4	0.0075
716	5-hydroxytryptamine 7 receptor	HTR7	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
1656	CYP2B protein	CYP2B	0.0074
2449	Tubulin alpha-3 chain	TUBA1A	0.0074
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0073
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0073
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0073
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0073
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0073
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0073
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0073
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0073
474	Acetylcholinesterase	ACHE	0.0073
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0073
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0073
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0073
6559	Cytochrome c oxidase subunit 2	ctaC	0.0073
6669	Cytochrome c oxidase subunit 2	ctaC	0.0073
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0073
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0073
6558	Cytochrome c oxidase subunit 1	ctaD	0.0073
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
482	Glycine receptor subunit alpha-1	GLRA1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
68	Cannabinoid receptor 1	CNR1	0.0071
5414	Fiber protein	L5	0.0071
5418	Fiber protein	L5	0.0071
1756	E-selectin	SELE	0.0071
5818	Folate receptor alpha	FOLR1	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.007
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.007
5251	Carbonyl reductase [NADPH] 1	CBR1	0.007
3939	Amine oxidase [flavin-containing] B	MAOB	0.007
3868	Calcineurin subunit B isoform 2	PPP3R2	0.007
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0069
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0069
2320	Thymidine kinase, cytosolic	TK1	0.0069
760	Fibroblast growth factor 1	FGF1	0.0069
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0069
5626	Nucleoside diphosphate kinase B	NME2	0.0068
1010	Cytochrome P450 51A1	CYP51A1	0.0067
88	Retinoic acid receptor RXR-beta	RXRB	0.0067
2540	Choloylglycine hydrolase	cbh	0.0067
36	Insulin receptor	INSR	0.0066
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0066
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0065
131	Synaptic vesicular amine transporter	SLC18A2	0.0065
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0063
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0063
4238	50S ribosomal protein L4	rplD	0.0063
5578	50S ribosomal protein L4	rplD	0.0063
6173	50S ribosomal protein L4	rplD	0.0063
6219	50S ribosomal protein L4	rplD	0.0063
427	Substance-P receptor	TACR1	0.0062
3270	Elongation factor G	fusA	0.0062
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0062
3629	Endo-N-acetylneuraminidase	Not Available	0.0062
569	Retinal dehydrogenase 2	ALDH1A2	0.0062
5416	Coat protein VP1	Not Available	0.0061
1130	Lithostathine 1 alpha	REG1A	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0059
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0059
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0059
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0059
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0059
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0059
611	Retinal dehydrogenase 1	ALDH1A1	0.0059
816	Biliverdin reductase A	BLVRA	0.0059
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0059
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0059
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0059
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
2599	Tyrosine-protein kinase HCK	HCK	0.0058
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0058
814	Ryanodine receptor 1	RYR1	0.0058
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0057
162	Retinoic acid receptor gamma-1	RARG	0.0057
2324	Botulinum neurotoxin type B	botB	0.0057
84	Nuclear receptor 0B1	NR0B1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
3547	Enterotoxin type B	entB	0.0057
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0056
2058	P-selectin	SELP	0.0056
5294	Nucleoside diphosphate kinase A	NME1	0.0056
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0056
4203	Histamine N-methyltransferase	HNMT	0.0056
6014	Cytochrome P450 2A13	CYP2A13	0.0055
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0055
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0054
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0054
6837	Serine/threonine-protein kinase 17B	STK17B	0.0054
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0054
6824	Tyrosine-protein kinase Lyn	LYN	0.0054
3086	Plasmepsin-2	Not Available	0.0053
473	L-lactate dehydrogenase A chain	LDHA	0.0053
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0053
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0053
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0053
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0053
328	Sorbitol dehydrogenase	SORD	0.0052
597	Dihydropteridine reductase	QDPR	0.0052
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0052
396	Alcohol dehydrogenase 4	ADH4	0.0052
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0052
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
1517	Beta-3 adrenergic receptor	ADRB3	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
1714	Mitogen-activated protein kinase 3	MAPK3	0.0051
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0051
94	5-hydroxytryptamine 4 receptor	HTR4	0.0051
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
1256	5-hydroxytryptamine 6 receptor	HTR6	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
780	Retinoic acid receptor RXR-gamma	RXRG	0.0049
1541	Metalloproteinase	mmp20	0.0049
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0049
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0049
2570	Tetanus toxin	tetX	0.0049
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0049
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0049
229	Retinoic acid receptor beta	RARB	0.0049
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0048
12	Alcohol dehydrogenase class 3	ADH5	0.0048
77	L-lactate dehydrogenase B chain	LDHB	0.0048
4210	Toll-like receptor 4	TLR4	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
357	Carbonic anhydrase 2	CA2	0.0048
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0048
730	Retinoic acid receptor alpha	RARA	0.0048
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
6174	50S ribosomal protein L32	rpmF	0.0047
6677	Myelin P2 protein	PMP2	0.0047
1178	Adenosine A2a receptor	ADORA2A	0.0047
4692	A/G-specific adenine glycosylase	mutY	0.0047
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0047
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0047
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0047
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0047
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0047
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0047
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0047
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0047
2216	Fibroblast growth factor receptor 4	FGFR4	0.0047
683	Potassium transporter	GK0582	0.0047
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0046
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0046
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0046
702	UMP-CMP kinase	CMPK1	0.0046
7	Nitric oxide synthase, inducible	NOS2	0.0046
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0046
2232	Interleukin-5	IL5	0.0045
1291	cAMP response element-binding protein	CREB1	0.0045
1593	Mucin-2	MUC2	0.0045
1483	Membrane copper amine oxidase	AOC3	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
595	Fibrinogen alpha chain	FGA	0.0044
563	Thyroid peroxidase	TPO	0.0044
251	Alcohol dehydrogenase 1A	ADH1A	0.0044
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0044
444	Alcohol dehydrogenase 1B	ADH1B	0.0044
106	Cannabinoid receptor 2	CNR2	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0043
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0043
856	Vitamin D3 receptor	VDR	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
4311	tRNA	TRDMT1	0.0043
4325	tRNA	trmD	0.0043
4328	tRNA	trmD	0.0043
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0042
163	D(1B) dopamine receptor	DRD5	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
2723	Cholera enterotoxin subunit B	ctxB	0.0042
484	Tyrosine-protein kinase ABL2	ABL2	0.0042
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0042
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0041
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0041
751	Potassium channel subfamily K member 6	KCNK6	0.0041
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0041
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0041
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0041
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0041
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0041
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0041
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0041
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0041
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0041
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0041
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0041
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0041
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0041
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0041
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0041
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0041
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0041
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0041
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0041
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0041
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0041
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0041
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0041
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0041
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0041
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0041
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0041
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0041
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0041
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0041
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0041
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0041
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0041
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0041
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0041
206	3-keto-steroid reductase	HSD17B7	0.0041
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0041
107	C-4 methylsterol oxidase	SC4MOL	0.0041
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0041
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0041
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0041
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0041
644	Heme oxygenase 2	HMOX2	0.0041
4982	Heme oxygenase 2	pbsA2	0.0041
729	GDP-L-fucose synthetase	TSTA3	0.0041
3463	GDP-L-fucose synthetase	fcl	0.0041
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0041
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0041
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0041
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0041
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0041
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0041
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0041
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0041
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0041
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0041
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0041
167	L-lactate dehydrogenase C chain	LDHC	0.0041
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0041
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0041
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0041
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0041
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0041
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0041
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0041
34	7-dehydrocholesterol reductase	DHCR7	0.0041
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0041
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0041
711	UDP-glucose 6-dehydrogenase	UGDH	0.0041
3672	UDP-glucose 6-dehydrogenase	hasB	0.0041
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0041
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0041
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0041
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0041
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0041
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0041
643	Peroxisomal bifunctional enzyme	EHHADH	0.0041
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0041
3679	MTA/SAH nucleosidase	mtnN	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
714	Glutathione reductase, mitochondrial	GSR	0.004
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
2207	Rhodopsin	RHO	0.004
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0039
295	Carbonic anhydrase 1	CA1	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
16	Adenosine A1 receptor	ADORA1	0.0039
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0039
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0039
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0039
128	Adenine phosphoribosyltransferase	APRT	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
5934	Cytochrome P450 26A1	CYP26A1	0.0038
4226	Uridine phosphorylase 2	UPP2	0.0038
1123	Eosinophil cationic protein	RNASE3	0.0038
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0037
172	Potassium channel subfamily K member 1	KCNK1	0.0037
6211	Tubulin epsilon chain	TUBE1	0.0037
6210	Tubulin delta chain	TUBD1	0.0037
6212	Tubulin gamma-1 chain	TUBG1	0.0037
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0037
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0037
1864	RET proto-oncogene	RET	0.0037
4103	Proteasome subunit beta type 2	PSMB2	0.0037
4102	Proteasome subunit beta type 5	PSMB5	0.0037
4101	Proteasome subunit beta type 1	PSMB1	0.0037
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0037
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0037
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0037
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0036
666	NADP-dependent malic enzyme	ME1	0.0036
1196	Complement decay-accelerating factor	CD55	0.0036
921	Glutamate receptor 2	GRIA2	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
4225	Uridine phosphorylase 1	UPP1	0.0036
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0035
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
857	Malate dehydrogenase, mitochondrial	MDH2	0.0035
4116	Dihydropteroate synthetase	Not Available	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0034
1992	Vitamin D-binding protein	GC	0.0034
6218	Pannexin-1	PANX1	0.0034
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0034
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0034
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0034
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0033
822	Aldose reductase	AKR1B1	0.0033
6432	Transporter	snf	0.0033
6033	High affinity interleukin-8 receptor A	CXCR1	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
6459	Glycodelin	PAEP	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
413	Amidophosphoribosyltransferase	PPAT	0.0033
2515	Amidophosphoribosyltransferase	purF	0.0033
3714	Amidophosphoribosyltransferase	purF	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0033
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0032
627	11-cis retinol dehydrogenase	RDH5	0.0032
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0032
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0032
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0032
626	Cysteine dioxygenase type 1	CDO1	0.0032
1867	Major prion protein	PRNP	0.0032
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0032
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
153	Dopamine beta-hydroxylase	DBH	0.0031
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
1648	Elastin	ELN	0.0031
976	Platelet glycoprotein IX	GP9	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
283	SEC14-like protein 2	SEC14L2	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.003
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
810	Heme oxygenase 1	HMOX1	0.0029
3391	Heme oxygenase 1	pbsA1	0.0029
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0029
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0029
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0029
2417	Chloramphenicol acetyltransferase	cat	0.0029
3278	Chloramphenicol acetyltransferase	cat	0.0029
3601	Dihydropteroate synthase 1	folP1	0.0029
3807	Dihydropteroate synthase 1	folP1	0.0029
3808	Dihydropteroate synthase 2	folP2	0.0029
2810	Dr hemagglutinin structural subunit	draA	0.0029
76	Nitric-oxide synthase, brain	NOS1	0.0029
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0028
65	Matrix metalloproteinase-9	Not Available	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
654	Flavin reductase	BLVRB	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
605	Fumarate reductase flavoprotein subunit	frdA	0.0027
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0027
3673	Fumarate reductase flavoprotein subunit	fccA	0.0027
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0027
6549	Fumarate reductase flavoprotein subunit	frdA	0.0027
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
279	Tyrosinase	TYR	0.0027
174	Sigma 1-type opioid receptor	SIGMAR1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3913	Glutamic acid decarboxylase	GAD65	0.0027
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0026
6048	Troponin C, skeletal muscle	TNNC2	0.0026
6228	Nuclear receptor coactivator 1	NCOA1	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
581	Cytochrome P450 2R1	CYP2R1	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
49	Endothelin B receptor	EDNRB	0.0026
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0026
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0026
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0026
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0026
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
518	Peroxidase/catalase T	katG	0.0025
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
3426	Glutamine synthetase	glnA	0.0025
3987	Glutamine synthetase	GLUL	0.0025
578	Endothelin-1 receptor	EDNRA	0.0024
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0024
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
4495	3-oxoacyl-(Acyl carrier protein) reductase	TM_1169	0.0023
4446	3alpha-hydroxysteroid dehydrogenase/carbonyl reductase	Not Available	0.0023
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.0023
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.0023
4428	Redox-sensing transcriptional repressor rex	rex	0.0023
4449	ADP-ribosyltransferase	Not Available	0.0023
4414	Dehydrogenase	TT_P0035	0.0023
2350	3-isopropylmalate dehydrogenase	leuB	0.0023
3092	3-isopropylmalate dehydrogenase	leuB	0.0023
4475	Hypothetical protein Rv0046c/MT0052	ino1	0.0023
4497	Benzyl alcohol dehydrogenase	xylB	0.0023
4506	Myo-inositol-1-phosphate synthase-related protein	TM_1419	0.0023
3735	NAD(P) transhydrogenase subunit alpha part 1	pntAA	0.0023
4472	Glucose 1-dehydrogenase	Not Available	0.0023
4423	Levodione reductase	lvr	0.0023
4505	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	bphB	0.0023
4443	Quinate/shikimate dehydrogenase	ydiB	0.0023
4456	Inorganic polyphosphate/ATP-NAD kinase	ppnK	0.0023
4502	Formate dehydrogenase	Not Available	0.0023
4448	L-2-hydroxyisocaproate dehydrogenase	Not Available	0.0023
4500	L-lactate dehydrogenase 2	ldh2	0.0023
4447	Hypothetical protein yhfP	yhfP	0.0023
3381	Alcohol dehydrogenase	Not Available	0.0023
4508	Alcohol dehydrogenase	adhA	0.0023
4471	CDP-D-glucose-4,6-dehydratase	ascB	0.0023
4418	AGR_L_3209p	AGR_L_3209	0.0023
4507	Alanine dehydrogenase	ald	0.0023
4455	Glycerol dehydrogenase	gldA	0.0023
4466	Glutathione-independent formaldehyde dehydrogenase	fdhA	0.0023
4487	Transcriptional regulator nadR	nadR	0.0023
3729	Citrate synthase	gltA	0.0023
4575	Citrate synthase	cit	0.0023
4580	Citrate synthase	gltA	0.0023
4435	L-aspartate dehydrogenase	nadX	0.0023
4451	Vip2Ac	vip2Ac	0.0023
4467	Alpha-glucosidase, putative	TM_0752	0.0023
735	Alanine aminotransferase 1	GPT	0.0023
3904	Alanine aminotransferase 2	GPT2	0.0023
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
291	Nitric-oxide synthase, endothelial	NOS3	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
719	Retinoic acid receptor responder protein 1	RARRES1	0.002
770	Retinoic acid-induced protein 3	GPRC5A	0.002
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
3191	Histidinol dehydrogenase	hisD	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4878	Glycoprotein hormones alpha chain	CGA	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.002
1072	Granzyme B	GZMB	0.002
4877	Beta-mannanase	man	0.002
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.002
4850	Beta-2-glycoprotein 1	APOH	0.002
4856	CD209 antigen	CD209	0.002
4889	Ig epsilon chain C region	IGHE	0.002
4869	Major capsid protein	A430L	0.002
4852	Reticulon-4 receptor	RTN4R	0.002
4880	Membrane cofactor protein	CD46	0.002
757	Fusion glycoprotein F0	F	0.002
4875	Fusion glycoprotein F0	F	0.002
4721	Beta-1,4-mannanase	manA	0.002
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.002
1354	Beta-glucuronidase	GUSB	0.002
442	Envelope glycoprotein	gp41	0.002
4859	Envelope glycoprotein	env	0.002
4189	Alpha-galactosidase A	GLA	0.002
4845	ADAM 33	ADAM33	0.002
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.002
3352	Structural polyprotein	Not Available	0.002
3628	Structural polyprotein	Not Available	0.002
4892	Structural polyprotein	Not Available	0.002
634	Squalene monooxygenase	SQLE	0.0019
7196	Squalene monooxygenase	ERG1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
4486	Phenol 2-hydroxylase component B	pheA2	0.0019
4439	Ferredoxin reductase	bphA4	0.0019
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0019
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0019
5117	Dihydrolipoyl dehydrogenase	lpd	0.0019
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0019
4503	NADPH-flavin oxidoreductase	frp	0.0019
3598	dTDP-4-dehydrorhamnose reductase	rfbD	0.0019
4427	TDP-glucose-4,6-dehydratase	desIV	0.0019
3177	dTDP-glucose 4,6-dehydratase	rfbB	0.0019
4499	dTDP-glucose 4,6-dehydratase	rmlB	0.0019
2967	CDP-paratose 2-epimerase	rfbE	0.0018
4482	UDP-galactose 4-epimerase	galE	0.0018
2507	Diphtheria toxin	Not Available	0.0018
2538	6-phospho-beta-glucosidase bglT	bglT	0.0018
2393	Maltose-6'-phosphate glucosidase	glvA	0.0018
3081	3-dehydroquinate synthase	aroB	0.0018
6698	Dehydrogenase/reductase SDR family member 4-like 2	DHRS4L2	0.0018
4450	Iota toxin component Ia	Not Available	0.0018
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.0018
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.0018
4509	Acetoin(diacetyl) reductase	budC	0.0018
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0018
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0018
2591	Urocanate hydratase	hutU	0.0018
4498	Ornithine cyclodeaminase	PP3533	0.0018
3615	Dihydrodipicolinate reductase	dapB	0.0018
3618	Dihydrodipicolinate reductase	dapB	0.0018
4462	Dihydrodipicolinate reductase	dapB	0.0018
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0018
2424	L-lactate dehydrogenase	ldh	0.0018
2641	L-lactate dehydrogenase	Not Available	0.0018
4437	L-lactate dehydrogenase	ldh	0.0018
4442	L-lactate dehydrogenase	ldh	0.0018
2336	2,3-diketo-L-gulonate reductase	dlgD	0.0018
126	D-lactate dehydrogenase	dld	0.0018
3545	D-lactate dehydrogenase	Not Available	0.0018
4510	D-lactate dehydrogenase	ldhA	0.0018
3401	D-2-hydroxyisocaproate dehydrogenase	Not Available	0.0018
4496	C-terminal-binding protein 1	CTBP1	0.0018
2018	Deoxyhypusine synthase	DHPS	0.0018
1199	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	0.0018
2881	Gamma-aminobutyraldehyde dehydrogenase	prr	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0017
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0017
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
2683	Mono-ADP-ribosyltransferase C3	C3	0.0017
3957	Adenosine deaminase	ADA	0.0017
6858	Inactive carboxylesterase 4	CES1P1	0.0017
793	T-cell surface antigen CD2	CD2	0.0017
4861	Interleukin-6 receptor alpha chain	IL6R	0.0017
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0017
3837	Cytokine receptor common beta chain	CSF2RB	0.0017
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0017
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
3296	Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	0.0017
4504	WbpP	Not Available	0.0017
4440	NADH peroxidase	npr	0.0017
3367	GDP-mannose 6-dehydrogenase	algD	0.0017
4318	Siroheme synthase	cysG	0.0017
2799	Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	Not Available	0.0017
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0016
4343	Alpha-glucosidase	aglA	0.0016
63	Malate dehydrogenase	mdh	0.0016
2329	Malate dehydrogenase	mdh	0.0016
3445	Malate dehydrogenase	mdh	0.0016
4420	Malate dehydrogenase	mdh	0.0016
4438	Malate dehydrogenase	mdh	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
4041	Microsomal glutathione S-transferase 2	MGST2	0.0016
173	Toll-like receptor 7	TLR7	0.0016
4890	Hemagglutinin	HA	0.0016
6566	Hemagglutinin	Not Available	0.0016
1379	Interleukin-12 subunit beta	IL12B	0.0016
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0016
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0016
3333	Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	0.0016
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0016
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0016
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0016
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0016
3070	Adenosylhomocysteinase	AHCY	0.0016
4424	Adenosylhomocysteinase	PFE1050w	0.0016
6278	Adenosylhomocysteinase	ahcY	0.0016
1184	Interferon beta	IFNB1	0.0015
2826	Glucose--fructose oxidoreductase	gfo	0.0015
327	Glutathione reductase	gor	0.0015
5110	Glutathione reductase	GR2	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0015
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0015
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
4491	DNA ligase, NAD-dependent	ligA	0.0014
2286	Isocitrate dehydrogenase [NADP]	icd	0.0014
2302	Isocitrate dehydrogenase [NADP]	icd	0.0014
2771	Isocitrate dehydrogenase [NADP]	icd	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1859	Prostatic acid phosphatase	ACPP	0.0014
3140	Hemagglutinin-neuraminidase	HN	0.0014
3609	Hemagglutinin-neuraminidase	HN	0.0014
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
3444	Cyanovirin-N	Not Available	0.0014
554	Low-density lipoprotein receptor	LDLR	0.0014
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
852	Heparin cofactor 2	SERPIND1	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
2762	UDP-glucose 4-epimerase	GALE	0.0014
3461	UDP-glucose 4-epimerase	galE	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
4787	Envelope glycoprotein gp160	env	0.0013
4820	Envelope glycoprotein gp160	env	0.0013
5727	Envelope glycoprotein gp160	env	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
164	Histamine H4 receptor	HRH4	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
4031	Glutathione S-transferase A1	GSTA1	0.0013
4666	Fucose-binding lectin PA-IIL	lecB	0.0013
2372	Bifunctional tail protein	9	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0012
292	Activin receptor type-1	ACVR1	0.0012
1295	Fatty acid synthase	FASN	0.0012
958	Insulin-like growth factor 1 receptor	IGF1R	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0012
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0012
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0012
6859	Protein S100-A4	S100A4	0.0012
268	Adenosine A2b receptor	ADORA2B	0.0012
1243	Cathepsin D	CTSD	0.0011
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0011
1268	Neuropeptide S receptor	NPSR1	0.0011
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0011
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0011
1439	Lactotransferrin	LTF	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0011
3814	Complement C1r subcomponent	C1R	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0011
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
2430	Chondroitinase B	cslB	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
6307	Ig gamma-2 chain C region	IGHG2	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2581	Chondroitinase AC	cslA	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
309	Antithrombin-III	SERPINC1	0.001
6073	Potassium channel subfamily K member 9	KCNK9	0.001
6072	Potassium channel subfamily K member 3	KCNK3	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
6847	Lactase-phlorizin hydrolase	LCT	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2298	Cytochrome P450-cam	camC	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
4785	Ig gamma-1 chain C region	IGHG1	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3221	Cytochrome c4	cc4	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
125	DNA polymerase beta	POLB	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
909	Maleylacetoacetate isomerase	GSTZ1	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
4943	Cytochrome c6	petJ	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4916	Cyanoglobin	glbN	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
5000	HemO	hemO	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
4984	Neuroglobin	NGB	0.0006
4961	Hemophore HasA	hasA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4909	CooA protein	cooA	0.0006
4910	Cytoglobin	CYGB	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4972	P450cin	cinA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4952	Catalase/peroxidase	katA	0.0006
3093	Catalase HPII	katE	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
4920	Peroxidase/catalase	katG	0.0005
5961	Insulin	INS	0.0005
4948	Cytochrome c-553	Not Available	0.0005
2119	Cytochrome b5	CYB5A	0.0005
4923	Cytochrome c3	DvMF_2499	0.0005
4945	Cytochrome c3	Not Available	0.0005
4949	Cytochrome c3	DVU_3171	0.0005
4968	Cytochrome c3	cytc3	0.0005
4997	Cytochrome c3	SO_2727	0.0005
5219	Cytochrome c3	cyd	0.0005
4902	Nine-heme cytochrome c	Ddes_2038	0.0005
3189	High-molecular-weight cytochrome c	hmcA	0.0005
4990	PpcA	ppcA	0.0005
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0005
3375	Acidic cytochrome c3	Not Available	0.0005
4988	Sulfite oxidase, mitochondrial	SUOX	0.0005
3570	Cytochrome P450 152A1	cypC	0.0005
2915	Sensor protein fixL	fixL	0.0005
4944	Sensor protein fixL	fixL	0.0005
4813	Heme oxygenase	hmuO	0.0005
5769	Heme oxygenase	Not Available	0.0005
4289	Cytochrome P450	TT_P0059	0.0005
6262	Cytochrome P450	staP	0.0005
4385	Cytochrome c'	Not Available	0.0005
4967	Cytochrome c'	cycA	0.0005
5038	Cytochrome c'	Not Available	0.0005
5223	Cytochrome c'	cycP	0.0005
4992	Cytochrome c peroxidase	Not Available	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
4386	Hemoglobin-like protein HbN	glbN	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
2802	Endoglucanase G	celCCG	0.0004
3127	Nitrite reductase	nirS	0.0004
3284	Nitrite reductase	nirS	0.0004
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0004
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
1507	Cytochrome c	CYCS	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00688 - Mycophenolate mofetil

Targets

Enzymes

Transporters

Carriers

Predictions