DT-Web

DB00893 - Iron Dextran


Identification
Name Iron Dextran
Accession Number DB00893 (APRD01053)
Type small molecule
Description Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.
Mechanism of action After iron dextran is injected, the circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiological forms of iron, or to a lesser extent to transferrin. This iron which is subject to physiological control replenishes hemoglobin and depleted iron stores.
Absorption The major portion of intramuscular injections of iron dextran is absorbed within 72 hours; most of the remaining iron is absorbed over the ensuing 3 to 4 weeks.
Protein binding 100% (after release from dextran)
Biotransformation Dextran, a polyglucose, is either metabolized or excreted.
Route of elimination Dextran, a polyglucose, is either metabolized or excreted.
Toxicity LD50 = 500 mg/kg (mouse, IV). Dosages of iron dextran in excess of the requirements for restoration of hemoglobin and replenishment of iron stores may lead to hemosiderosis. Cases of severe, sometimes fatal, allergic reactions (loss of consciousness, collapse, difficulty breathing, hives, swelling, or convulsions) and severe low blood pressure (hypotension) have been reported with the use of iron dextran.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Alendronate Formation of non-absorbable complexes
Ciprofloxacin Formation of non-absorbable complexes
Clodronate Formation of non-absorbable complexes
Deferiprone Deferiprone may decrease gastrointestinal absorption by chelating to other ions. Interaction is significant so monitor closely.
Demeclocycline Formation of non-absorbable complexes
Doxycycline Formation of non-absorbable complexes
Eltrombopag Levels of eltrombopag are decreased due to GI inhibition. Separate administration by at least 4 hours.
Enoxacin Formation of non-absorbable complexes
Etidronic acid Formation of non-absorbable complexes
Gatifloxacin Formation of non-absorbable complexes
Gemifloxacin Formation of non-absorbable complexes
Grepafloxacin Formation of non-absorbable complexes
Ibandronate Formation of non-absorbable complexes
Levodopa Iron decreases the absorption of dopa derivatives
Levofloxacin Formation of non-absorbable complexes
Levothyroxine Iron decreases the absorption of levothyroxine
Lomefloxacin Formation of non-absorbable complexes
Methacycline Formation of non-absorbable complexes
Methyldopa Iron decreases the absorption of dopa derivatives
Minocycline Formation of non-absorbable complexes
Moxifloxacin Formation of non-absorbable complexes
Mycophenolate mofetil Oral iron decreases the absorption of mycophenolate-mofetil
Norfloxacin Formation of non-absorbable complexes
Ofloxacin Formation of non-absorbable complexes
Oxytetracycline Formation of non-absorbable complexes
Pefloxacin Formation of non-absorbable complexes
Penicillamine The multivalent agent decreases the effect of penicillamine
Risedronate Formation of non-absorbable complexes
Temafloxacin Formation of non-absorbable complexes
Tetracycline Formation of non-absorbable complexes
Trovafloxacin Formation of non-absorbable complexes
Food Interactions Not Available

Targets


Hemoglobin subunit beta
Name Hemoglobin subunit beta
Gene Name HBB
Pharmacological action yes
Actions activator
References
  • Zaric J, Lazic D, Markovic S, Glisin V, Ivanovic Z, Milenkovic P, Popovic Z: Alpha- and beta-globins of the anemic Belgrade laboratory rat. II. The effect of hemin and iron-dextran treatment. Hemoglobin. 1998 May;22(3):231-44. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.9393
Hemoglobin subunit alpha
Name Hemoglobin subunit alpha
Gene Name HBA1
Pharmacological action yes
Actions activator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.9156
Ferritin heavy chain
Name Ferritin heavy chain
Gene Name FTH1
Pharmacological action yes
Actions other
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8179
Ferritin light chain
Name Ferritin light chain
Gene Name FTL
Pharmacological action yes
Actions other
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6806

Carriers


Predictions


Id Partner name Gene Name Score
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.119
587 Serum albumin ALB 0.0784
5142 Protein-tyrosine-phosphatase PPI 0.0744
6315 V-type proton ATPase subunit B, brain isoform ATP6V1B2 0.0659
1654 Interleukin-1 beta IL1B 0.062
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0608
798 Osteocalcin BGLAP 0.0535
1178 Adenosine A2a receptor ADORA2A 0.0155
474 Acetylcholinesterase ACHE 0.0132
3811 Cytochrome P450 19A1 CYP19A1 0.0116
3923 Cholinesterase BCHE 0.011
1588 Multidrug resistance protein 1 ABCB1 0.0079
4119 Cytochrome P450 2D6 CYP2D6 0.0077
4512 Cytochrome P450 3A4 CYP3A4 0.0074
4915 Cytochrome c-550 psbV 0.0024
4959 Cytochrome c-550 psbV 0.0024
5216 Cytochrome c-550 psbV 0.0024
4947 Bacterial hemoglobin vhb 0.0024
4916 Cyanoglobin glbN 0.0024
4975 Cytochrome c-556 RPA3973 0.0024
4943 Cytochrome c6 petJ 0.0024
4954 Soluble cytochrome b558 Not Available 0.0024
4934 Cytochrome c-551 nirM 0.0024
5218 Cytochrome c-551 nirM 0.0024
4961 Hemophore HasA hasA 0.0024
4905 Cytochrome c2 Not Available 0.0024
4939 Cytochrome c2 cycA 0.0024
4964 Cytochrome c2 cycA 0.0024
4979 Cytochrome c2 cycA 0.0024
6673 Cytochrome c2 cycA 0.0024
4942 Diheme cytochrome c napB napB 0.0024
4907 Cytochrome c-L moxG 0.0024
6865 Cytochrome c-L moxG 0.0024
4981 Iron-starvation protein PigA pigA 0.0024
4936 Cytochrome c2 iso-2 Not Available 0.0024
4994 Hemoglobin-like protein HbO glbO 0.0024
4925 Cytochrome c-type protein SHP shp 0.0024
5000 HemO hemO 0.0024
4998 Hemoglobin-like protein yjbI yjbI 0.0024
644 Heme oxygenase 2 HMOX2 0.0024
4982 Heme oxygenase 2 pbsA2 0.0024
4984 Neuroglobin NGB 0.0024
3116 Bacterioferritin bfr 0.0024
4906 Bacterioferritin bfr 0.0024
4965 Bacterioferritin bfr 0.0024
4989 Cytochrome c551 peroxidase ccp 0.0024
5222 Cytochrome c551 peroxidase ccpA 0.0024
4910 Cytoglobin CYGB 0.0024
4909 CooA protein cooA 0.0023
4972 P450cin cinA 0.0023
4764 Cytochrome P450 165C4 CYP165C4 0.0023
4960 Putative cytochrome P450-family protein SCO7417 0.0023
4971 Nonaheme cytochrome c hmcA 0.0023
4935 Cytochrome c-554 cycA1 0.0023
4926 Heme-based aerotactic transducer hemAT hemAT 0.0023
4952 Catalase/peroxidase katA 0.0023
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0023
4937 Cytochrome oxidase subunit II rcoxA 0.0023
4993 Hydroxylamine oxidoreductase hao1 0.0023
4976 Apocytochrome f petA 0.0023
6407 Apocytochrome f petA 0.0023
4904 Cytochrome c family protein GSU1996 0.0023
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0023
4999 Cytochrome P450 165B3 CYP165B3 0.0023
4931 Cytochrome P450 167A1 CYP167A1 0.0023
4922 Cytochrome c, putative SO_4144 0.0023
4903 Methyl-accepting chemotaxis protein Tar4 0.0023
3093 Catalase HPII katE 0.0023
4990 PpcA ppcA 0.0021
4948 Cytochrome c-553 Not Available 0.002
4813 Heme oxygenase hmuO 0.002
5769 Heme oxygenase Not Available 0.002
3375 Acidic cytochrome c3 Not Available 0.002
4385 Cytochrome c' Not Available 0.002
4967 Cytochrome c' cycA 0.002
5038 Cytochrome c' Not Available 0.002
5223 Cytochrome c' cycP 0.002
4923 Cytochrome c3 DvMF_2499 0.002
4945 Cytochrome c3 Not Available 0.002
4949 Cytochrome c3 DVU_3171 0.002
4968 Cytochrome c3 cytc3 0.002
4997 Cytochrome c3 SO_2727 0.002
5219 Cytochrome c3 cyd 0.002
4037 Hypothetical protein GPX1 0.002
4297 Hypothetical protein SP_1951 0.002
4521 Hypothetical protein BC_2969 0.002
4540 Hypothetical protein TM_1070 0.002
4555 Hypothetical protein MT1739 0.002
4569 Hypothetical protein mshD 0.002
4578 Hypothetical protein PA3270 0.002
4747 Hypothetical protein PA3967 0.002
5177 Hypothetical protein TM_0096 0.002
5194 Hypothetical protein PA1204 0.002
5240 Hypothetical protein Rv2991 0.002
5370 Hypothetical protein TM_1158 0.002
5710 Hypothetical protein Tb927.5.1360 0.002
2119 Cytochrome b5 CYB5A 0.002
4992 Cytochrome c peroxidase Not Available 0.002
4289 Cytochrome P450 TT_P0059 0.002
6262 Cytochrome P450 staP 0.002
4902 Nine-heme cytochrome c Ddes_2038 0.002
3570 Cytochrome P450 152A1 cypC 0.002
2915 Sensor protein fixL fixL 0.002
4944 Sensor protein fixL fixL 0.002
3189 High-molecular-weight cytochrome c hmcA 0.002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.002
4920 Peroxidase/catalase katG 0.002
4988 Sulfite oxidase, mitochondrial SUOX 0.002
3670 Soluble cytochrome b562 precursor cybC 0.0019
3291 Cytochrome c-552 cycA 0.0019
4927 Cytochrome c-552 nrfA 0.0019
4938 Cytochrome c-552 cycA 0.0019
4953 Cytochrome c-552 nrfA 0.0019
5217 Cytochrome c-552 cycM 0.0019
4386 Hemoglobin-like protein HbN glbN 0.0019
2617 Nitric oxide synthase oxygenase nos 0.0019
2701 Nitric oxide synthase oxygenase nos 0.0019
3411 Cytochrome P450 121 cyp121 0.0019
3102 Flavohemoprotein hmp 0.0019
4969 Flavohemoprotein hmp 0.0019
3221 Cytochrome c4 cc4 0.0018
3127 Nitrite reductase nirS 0.0018
3284 Nitrite reductase nirS 0.0018
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0018
2230 Catalase CAT 0.0017
3249 Catalase katA 0.0017
3625 Catalase katA 0.0017
4539 Catalase katA 0.0017
4941 Catalase katB 0.0017
4608 Putative cytochrome P450 SCO1207 0.0017
4963 Putative cytochrome P450 SCO2884 0.0017
6254 Putative cytochrome P450 SCO6998 0.0017
605 Fumarate reductase flavoprotein subunit frdA 0.0017
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0017
3673 Fumarate reductase flavoprotein subunit fccA 0.0017
4912 Fumarate reductase flavoprotein subunit ifcA 0.0017
6549 Fumarate reductase flavoprotein subunit frdA 0.0017
2972 6-deoxyerythronolide B hydroxylase eryF 0.0016
260 Cytochrome P450 51 ERG11 0.0016
761 Cytochrome P450 51 ERG11 0.0016
3163 Cytochrome P450 51 cyp51 0.0016
518 Peroxidase/catalase T katG 0.0015
1507 Cytochrome c CYCS 0.0015
6268 Hydroxyacid oxidase 1 HAO1 0.0015
810 Heme oxygenase 1 HMOX1 0.0014
3391 Heme oxygenase 1 pbsA1 0.0014
358 Cystathionine beta-synthase CBS 0.0013
2298 Cytochrome P450-cam camC 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0012
7 Nitric oxide synthase, inducible NOS2 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
275 Arachidonate 5-lipoxygenase ALOX5 0.0011
6106 Cytochrome P450 2C18 CYP2C18 0.0009
290 Prostaglandin G/H synthase 2 PTGS2 0.0008
20 Prostaglandin G/H synthase 1 PTGS1 0.0007
6030 Cytochrome P450 2B6 CYP2B6 0.0007
4924 Cytochrome P450 2C8 CYP2C8 0.0006
4757 Cytochrome P450 2C9 CYP2C9 0.0006
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