DT-Web

DB00759 - Tetracycline


Identification
Name Tetracycline
Accession Number DB00759 (APRD00572)
Type small molecule
Description Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 444.4346
Groups approved
Monoisotopic Weight 444.153265754
Pharmacology
Indication Used to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, rickettsialpox and Brill-Zinsser disease. May be used to treat infections caused by Chlamydiae spp., B. burgdorferi (Lyme disease), and upper respiratory infections caused by typical (S. pneumoniae, H. influenzae, and M. catarrhalis) and atypical organisms (C. pneumoniae, M. pneumoniae, L. pneumophila). May also be used to treat acne. Tetracycline may be an alternative drug for people who are allergic to penicillin.
Mechanism of action Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.
Absorption Bioavailability is less than 40% when administered via intramuscular injection, 100% intravenously, and 60-80% orally (fasting adults). Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more.
Protein binding 20 - 67% protein bound
Biotransformation Not metabolized
Route of elimination They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations in a biologically active form.
Toxicity LD50=808mg/kg (orally in mice)
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Tetracycline may increase the anticoagulant effect of acenocoumarol.
Acitretin Increased risk of intracranial hypertension
Aluminium Formation of non-absorbable complexes
Amoxicillin Possible antagonism of action
Ampicillin Possible antagonism of action
Anisindione Tetracycline may increase the anticoagulant effect of anisindione.
Atovaquone Tetracycline may decrease the effect of atovaquone.
Attapulgite Formation of non-absorbable complexes
Azlocillin Possible antagonism of action
Aztreonam Possible antagonism of action
Bacampicillin Possible antagonism of action
Bexarotene Tetracycline may enhance the adverse/toxic effect of Retinoic Acid Derivatives. Due to the risk of developing pseudotumor cerebri (also known as intracranial hypertension), avoid this combination of drugs if possible. If used concomitantly, monitor for evidence of this interaction (eg, dizziness, diplopia, headache).
Bismuth Subsalicylate Formation of non-absorbable complexes
Calcium Formation of non-absorbable complexes
Calcium Acetate Calcium salts such as calcium acetate may decrease the serum concentration of tetracycline derivatives such as tetracycline. In general, the coadministration of oral calcium salts and oral tetracycline derivatives should be avoided. Interactions may be able to be minimized by administering oral calcium preparations several hours before or after the dose of the oral tetracycline derivatives. Even with dose separation, therapy may still be compromised. Monitor for decreased therapeutic effect of oral tetracycline derivatives.
Calcium Chloride Calcium salts such as calcium chloride may decrease the serum concentration of tetracycline derivatives such as tetracycline. In general, the coadministration of oral calcium salts and oral tetracycline derivatives should be avoided. Interactions may be able to be minimized by administering oral calcium preparations several hours before or after the dose of the oral tetracycline derivatives. Even with dose separation, therapy may still be compromised. Monitor for decreased therapeutic effect of oral tetracycline derivatives.
Carbenicillin Possible antagonism of action
Clavulanate Possible antagonism of action
Cloxacillin Possible antagonism of action
Colesevelam Bile acid sequestrants such as colesevelam may decrease the absorption of Tetracycline Derivatives. Monitor for decreased therapeutic effects of tetracycline derivatives if coadministered with a bile acid sequestrant. If these agents are used concomitantly, separate doses 2 or more hours to minimize the interaction. The manufacturer of colesevelam suggests that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclacillin Possible antagonism of action
Dicloxacillin Possible antagonism of action
Dicumarol Tetracycline may increase the anticoagulant effect of dicumarol.
Dihydroxyaluminium Formation of non-absorbable complexes
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Etretinate Increased risk of intracranial hypertension
Flucloxacillin Possible antagonism of action
Hetacillin Possible antagonism of action
Iron Formation of non-absorbable complexes
Iron Dextran Formation of non-absorbable complexes
Isotretinoin Increased risk of intracranial hypertension
Magnesium Formation of non-absorbable complexes
Magnesium salicylate Formation of non-absorbable complexes
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Methicillin Acyl-Serine Possible antagonism of action
Methotrexate Tetracycline may increase methotrexate toxicity.
Methoxyflurane Tetracycline may increase the renal toxicity of methoxyflurane.
Mezlocillin Possible antagonism of action
Nafcillin Possible antagonism of action
Oxacillin Possible antagonism of action
Penicillin G Possible antagonism of action
Penicillin V Possible antagonism of action
Piperacillin Possible antagonism of action
Pivampicillin Possible antagonism of action
Pivmecillinam Possible antagonism of action
Quinapril Quinapril may decrease the absorption of tetracycline.
Tamsulosin Tetracycline, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Tetracycline is initiated, discontinued, or dose changed.
Tazobactam Possible antagonism of action
Ticarcillin Tetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Tetracycline.
Tolterodine Tetracycline may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Tetracycline may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Tetracycline, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Tetracycline is initiated, discontinued or dose changed.
Tretinoin Demeclocycline may increase the adverse effects of oral Tretinoin. Increase risk of pseudotumour cerebri. Concurrent therapy should be avoided.
Trisalicylate-choline Formation of non-absorbable complexes
Warfarin Tetracycline may increase the anticoagulant effect of warfarin.
Zinc Formation of non-absorbable complexes
Food Interactions
  • Avoid milk, calcium containing dairy products, iron, antacids, or aluminium salts 2 hours before or 6 hours after using antacids while on this medication.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.

Targets


30S ribosomal protein S7
Name 30S ribosomal protein S7
Gene Name rpsG
Pharmacological action yes
Actions inhibitor
References
  • Buck MA, Cooperman BS: Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes. Biochemistry. 1990 Jun 5;29(22):5374-9. - Pubmed
DTHybrid score Not Available
30S ribosomal protein S14
Name 30S ribosomal protein S14
Gene Name rpsN
Pharmacological action yes
Actions inhibitor
References
  • Buck MA, Cooperman BS: Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes. Biochemistry. 1990 Jun 5;29(22):5374-9. - Pubmed
DTHybrid score 0.7186
30S ribosomal protein S3
Name 30S ribosomal protein S3
Gene Name rpsC
Pharmacological action yes
Actions inhibitor
References
  • Buck MA, Cooperman BS: Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes. Biochemistry. 1990 Jun 5;29(22):5374-9. - Pubmed
DTHybrid score Not Available
30S ribosomal protein S8
Name 30S ribosomal protein S8
Gene Name rpsH
Pharmacological action yes
Actions inhibitor
References
  • Buck MA, Cooperman BS: Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes. Biochemistry. 1990 Jun 5;29(22):5374-9. - Pubmed
DTHybrid score Not Available
30S ribosomal protein S19
Name 30S ribosomal protein S19
Gene Name rpsS
Pharmacological action yes
Actions inhibitor
References
  • Buck MA, Cooperman BS: Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes. Biochemistry. 1990 Jun 5;29(22):5374-9. - Pubmed
DTHybrid score 0.7187
16S rRNA
Name 16S rRNA
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Nawaz M, Sung K, Khan SA, Khan AA, Steele R: Biochemical and molecular characterization of tetracycline-resistant Aeromonas veronii isolates from catfish. Appl Environ Microbiol. 2006 Oct;72(10):6461-6. - Pubmed
  • Domingue GJ Sr: Cryptic bacterial infection in chronic prostatitis: diagnostic and therapeutic implications. Curr Opin Urol. 1998 Jan;8(1):45-9. - Pubmed
  • Pringle M, Fellstrom C, Johansson KE: Decreased susceptibility to doxycycline associated with a 16S rRNA gene mutation in Brachyspira hyodysenteriae. Vet Microbiol. 2007 Jul 20;123(1-3):245-8. Epub 2007 Feb 25. - Pubmed
  • Rasmussen B, Noller HF, Daubresse G, Oliva B, Misulovin Z, Rothstein DM, Ellestad GA, Gluzman Y, Tally FP, Chopra I: Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome. Antimicrob Agents Chemother. 1991 Nov;35(11):2306-11. - Pubmed
DTHybrid score Not Available
Major prion protein
Name Major prion protein
Gene Name PRNP
Pharmacological action unknown
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • De Luigi A, Colombo L, Diomede L, Capobianco R, Mangieri M, Miccolo C, Limido L, Forloni G, Tagliavini F, Salmona M: The efficacy of tetracyclines in peripheral and intracerebral prion infection. PLoS One. 2008 Mar 26;3(3):e1888. - Pubmed
DTHybrid score 0.4501

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4169

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.5702
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.5001
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.4285
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions inhibitor
References
  • Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. - Pubmed
DTHybrid score 0.3803

Carriers


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.5702
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions
References Not Available
DTHybrid score 0.5001
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions
References Not Available
DTHybrid score 0.4285
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions
References Not Available
DTHybrid score 0.3803

Predictions


Id Partner name Gene Name Score
6712 30S ribosomal protein S19 rpsS 0.7187
6726 30S ribosomal protein S19 rpsS 0.7187
6208 30S ribosomal protein S13 rpsM 0.3677
6706 30S ribosomal protein S13 rpsM 0.3677
140 30S ribosomal protein S9 rpsI 0.2815
6719 30S ribosomal protein S9 rpsI 0.2815
6725 30S ribosomal protein S9 rpsI 0.2815
308 30S ribosomal protein S12 rpsL 0.1627
6704 30S ribosomal protein S12 rpsL 0.1627
4757 Cytochrome P450 2C9 CYP2C9 0.1389
1588 Multidrug resistance protein 1 ABCB1 0.1366
6016 Cytochrome P450 2C19 CYP2C19 0.1028
4924 Cytochrome P450 2C8 CYP2C8 0.1011
4200 Cytochrome P450 1A2 CYP1A2 0.095
20 Prostaglandin G/H synthase 1 PTGS1 0.09
4119 Cytochrome P450 2D6 CYP2D6 0.0889
290 Prostaglandin G/H synthase 2 PTGS2 0.0889
4118 Cytochrome P450 3A5 CYP3A5 0.0888
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0877
2164 Multidrug resistance-associated protein 4 ABCC4 0.0733
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0693
118 Organic cation/carnitine transporter 2 SLC22A5 0.0655
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0646
6107 Cytochrome P450 3A7 CYP3A7 0.0592
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.059
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0574
862 Multidrug resistance-associated protein 1 ABCC1 0.0546
6145 Solute carrier family 22 member 1 SLC22A1 0.0524
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0522
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.049
6030 Cytochrome P450 2B6 CYP2B6 0.0477
6144 Solute carrier family 22 member 2 SLC22A2 0.0475
22 30S ribosomal protein S4 rpsD 0.047
6714 30S ribosomal protein S4 rpsD 0.047
6013 Cytochrome P450 2E1 CYP2E1 0.0453
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0423
1181 Alpha-1-acid glycoprotein 1 ORM1 0.041
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0405
738 Monocarboxylate transporter 1 SLC16A1 0.0403
6024 Cytochrome P450 1A1 CYP1A1 0.0373
776 Bile salt export pump ABCB11 0.0359
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0353
645 Penicillin-binding protein 1A mrcA 0.0345
5805 Penicillin-binding protein 1A ponA 0.0345
6185 Penicillin-binding protein 1A mrcA 0.0345
6799 Penicillin-binding protein 1A pbpA 0.0345
633 Penicillin-binding proteins 1A/1B pbpA 0.0344
6136 Multidrug resistance-associated protein 5 ABCC5 0.0337
6141 Sodium/bile acid cotransporter SLC10A1 0.033
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0326
543 Penicillin-binding protein 1B mrcB 0.0319
6186 Penicillin-binding protein 1B ponB 0.0319
6822 Penicillin-binding protein 1b pbp1b 0.0319
6844 Penicillin-binding protein 1b pbp1b 0.0319
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0302
5718 Cytochrome P450 2A6 CYP2A6 0.0299
338 DNA polymerase UL30 0.0297
379 DNA polymerase UL54 0.0297
697 DNA polymerase ORF28 0.0297
2482 DNA polymerase 43 0.0297
4104 DNA polymerase BALF5 0.0297
833 Organic cation/carnitine transporter 1 SLC22A4 0.0295
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0275
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0273
5353 Glutamate decarboxylase alpha gadA 0.027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0265
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0261
438 Taste receptor type 1 member 2 TAS1R2 0.0248
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0244
6020 Aldehyde oxidase AOX1 0.0238
558 Solute carrier family 12 member 1 SLC12A1 0.0237
6149 Solute carrier family 22 member 10 SLC22A10 0.0235
3811 Cytochrome P450 19A1 CYP19A1 0.0233
1 Peptidoglycan synthetase ftsI ftsI 0.0226
4155 Peptidoglycan synthetase ftsI ftsI 0.0226
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
891 Dihydropteroate synthase folP 0.022
5359 Dihydropteroate synthase folP 0.022
7175 Dihydropteroate synthase sulI 0.022
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0217
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0217
115 Penicillin-binding protein 2 mrdA 0.021
6069 Penicillin-binding protein 2 mrdA 0.021
6118 Penicillin-binding protein 2 penA 0.021
6187 Penicillin-binding protein 2 pbpA 0.021
6686 Penicillin-binding protein 2 pbp2 0.021
6939 Penicillin-binding protein 2 mrdA 0.021
7163 Penicillin-binding protein 2 pbpA 0.021
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
357 Carbonic anhydrase 2 CA2 0.0203
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
6147 Solute carrier family 22 member 3 SLC22A3 0.0197
2016 Dipeptidase 1 DPEP1 0.0197
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0196
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0196
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
592 Carbonic anhydrase 4 CA4 0.0191
3947 Xanthine dehydrogenase/oxidase XDH 0.0188
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0186
6106 Cytochrome P450 2C18 CYP2C18 0.0186
136 Estrogen receptor ESR1 0.018
871 Glucocorticoid receptor NR3C1 0.0178
295 Carbonic anhydrase 1 CA1 0.0176
492 Histamine H1 receptor HRH1 0.0174
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0173
6033 High affinity interleukin-8 receptor A CXCR1 0.0173
6148 Multidrug resistance-associated protein 7 ABCC10 0.0172
183 Vascular endothelial growth factor A VEGFA 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0168
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
1898 Cytochrome P450 1B1 CYP1B1 0.0166
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.016
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
404 DNA gyrase subunit A gyrA 0.0158
6224 DNA gyrase subunit A gyrA 0.0158
4604 Liver carboxylesterase 1 CES1 0.0157
756 Sex hormone-binding globulin SHBG 0.0157
275 Arachidonate 5-lipoxygenase ALOX5 0.0156
502 5-hydroxytryptamine 2A receptor HTR2A 0.0153
527 Prostacyclin receptor PTGIR 0.0152
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0151
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0149
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
672 Prostaglandin F2-alpha receptor PTGFR 0.0148
373 Transthyretin TTR 0.0148
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.014
220 Sodium channel protein type 5 subunit alpha SCN5A 0.014
867 Penicillin-binding protein 3 pbpC 0.014
6119 Penicillin-binding protein 3 pbp3 0.014
7154 Penicillin-binding protein 3 pbp3 0.014
7157 Penicillin-binding protein 3 LMHCC_2184 0.014
7162 Penicillin-binding protein 3 pbpB 0.014
7172 Penicillin-binding protein 3 pbp3 0.014
124 Histamine H2 receptor HRH2 0.0139
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0139
2320 Thymidine kinase, cytosolic TK1 0.0139
1654 Interleukin-1 beta IL1B 0.0137
6031 Cytochrome P450 3A43 CYP3A43 0.0137
6167 Organic solute transporter subunit beta OSTB 0.0136
6166 Organic solute transporter subunit alpha OSTA 0.0135
3639 Thymidine phosphorylase deoA 0.0135
3936 Thymidine phosphorylase TYMP 0.0135
556 Alpha-1A adrenergic receptor ADRA1A 0.0134
3760 Penicillin-binding protein 5 precursor dacA 0.0131
831 D(2) dopamine receptor DRD2 0.0131
130 Prostacyclin synthase PTGIS 0.0131
65 Matrix metalloproteinase-9 Not Available 0.0131
6043 Putative G-protein coupled receptor 44 GPR44 0.0131
320 5-hydroxytryptamine 1A receptor HTR1A 0.0129
3426 Glutamine synthetase glnA 0.0129
3987 Glutamine synthetase GLUL 0.0129
3685 Catabolite gene activator crp 0.0127
53 Solute carrier family 12 member 5 SLC12A5 0.0127
663 Solute carrier family 12 member 4 SLC12A4 0.0127
4655 Adenylate cyclase cyaC 0.0127
4759 Adenylate cyclase cyaB2 0.0127
5626 Nucleoside diphosphate kinase B NME2 0.0127
819 Penicillin-binding protein 4 dacB 0.0125
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0125
244 Angiotensin-converting enzyme ACE 0.0124
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0122
146 Androgen receptor AR 0.012
1198 Serum paraoxonase/arylesterase 1 PON1 0.012
6223 Penicillin-binding protein 1C pbpC 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
310 Solute carrier family 12 member 2 SLC12A2 0.0119
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0118
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0117
4217 Telomerase reverse transcriptase TERT 0.0116
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0116
23 D(1A) dopamine receptor DRD1 0.0116
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0116
6126 Carbonic anhydrase 7 CA7 0.0115
6137 Multidrug resistance-associated protein 6 ABCC6 0.0114
6085 Fatty acid-binding protein, intestinal FABP2 0.0113
824 Sodium-dependent serotonin transporter SLC6A4 0.0113
3917 Methylenetetrahydrofolate reductase MTHFR 0.0113
818 50S ribosomal protein L10 rplJ 0.0111
494 Caspase-1 CASP1 0.0111
723 Cytosolic phospholipase A2 PLA2G4A 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
1405 Thiopurine S-methyltransferase TPMT 0.0109
4760 Mll3241 protein mll3241 0.0109
847 Mu-type opioid receptor OPRM1 0.0109
1507 Cytochrome c CYCS 0.0107
24 Thymidylate synthase TMP1 0.0107
359 Thymidylate synthase TYMS 0.0107
2626 Thymidylate synthase thyA 0.0107
2729 Thymidylate synthase thyA 0.0107
5352 Thymidylate synthase THYA 0.0107
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0105
5294 Nucleoside diphosphate kinase A NME1 0.0103
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0101
4122 Histone deacetylase 2 HDAC2 0.01
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0099
2211 Fatty acid-binding protein, heart FABP3 0.0098
632 Alpha-1B adrenergic receptor ADRA1B 0.0098
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0095
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0095
566 Serotransferrin TF 0.0094
731 HIV-1 protease HIV-1 protease 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
2077 Caspase-3 CASP3 0.0093
16 Adenosine A1 receptor ADORA1 0.0092
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0092
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0092
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0091
318 Alpha-2A adrenergic receptor ADRA2A 0.009
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
1178 Adenosine A2a receptor ADORA2A 0.009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0086
705 Glutamate receptor 1 GRIA1 0.0085
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0084
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0083
467 Delta-type opioid receptor OPRD1 0.0083
2981 Phospholipase A2, membrane associated PLA2G2A 0.0083
477 DNA topoisomerase 4 subunit A parC 0.0083
886 DNA topoisomerase 4 subunit A parC 0.0083
6226 DNA topoisomerase 4 subunit A parC 0.0083
4237 50S ribosomal protein L22 rplV 0.0082
3932 Glutathione S-transferase A2 GSTA2 0.0082
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
817 DNA topoisomerase 2-alpha TOP2A 0.008
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.008
51 Muscarinic acetylcholine receptor M3 CHRM3 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0079
6218 Pannexin-1 PANX1 0.0079
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0079
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0079
293 Gamma-glutamyl hydrolase GGH 0.0078
273 Apoptosis regulator Bcl-2 BCL2 0.0078
696 Kappa-type opioid receptor OPRK1 0.0078
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0078
614 Progesterone receptor PGR 0.0077
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0077
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0077
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0076
3923 Cholinesterase BCHE 0.0075
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0075
4773 Deoxycytidine kinase DCK 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
537 ATP synthase delta chain, mitochondrial ATP5D 0.0073
6014 Cytochrome P450 2A13 CYP2A13 0.0072
482 Glycine receptor subunit alpha-1 GLRA1 0.0072
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0071
6131 Carbonic anhydrase 14 CA14 0.0071
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
594 Thyroxine-binding globulin SERPINA7 0.007
4238 50S ribosomal protein L4 rplD 0.007
5578 50S ribosomal protein L4 rplD 0.007
6173 50S ribosomal protein L4 rplD 0.007
6219 50S ribosomal protein L4 rplD 0.007
70 Type-1 angiotensin II receptor AGTR1 0.0069
260 Cytochrome P450 51 ERG11 0.0069
761 Cytochrome P450 51 ERG11 0.0069
3163 Cytochrome P450 51 cyp51 0.0069
952 Dipeptidyl peptidase 4 DPP4 0.0069
1650 Heme carrier protein 1 SLC46A1 0.0069
5818 Folate receptor alpha FOLR1 0.0068
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0068
6042 Prostaglandin reductase 2 PTGR2 0.0068
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0067
36 Insulin receptor INSR 0.0066
6122 Carbonic anhydrase 3 CA3 0.0066
29 Tubulin beta-1 chain TUBB1 0.0066
2021 Thrombomodulin THBD 0.0065
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0065
758 Thyroid hormone receptor alpha THRA 0.0065
844 Epidermal growth factor receptor EGFR 0.0064
590 5-hydroxytryptamine 2C receptor HTR2C 0.0064
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0064
3941 Amine oxidase [flavin-containing] A MAOA 0.0064
122 P2Y purinoceptor 12 P2RY12 0.0062
789 Alpha-1D adrenergic receptor ADRA1D 0.0061
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0061
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0061
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.006
1757 Myeloperoxidase MPO 0.006
869 Estrogen receptor beta ESR2 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
811 Translocator protein TSPO 0.0059
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0058
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0058
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0058
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0058
346 Thyroid hormone receptor beta-1 THRB 0.0058
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0057
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0057
3007 Carbonic anhydrase 12 CA12 0.0057
4205 Carbonic anhydrase 9 CA9 0.0057
341 5-hydroxytryptamine 3 receptor HTR3A 0.0056
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0056
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0056
468 Cytochrome P450 4A11 CYP4A11 0.0055
459 Retinoic acid receptor RXR-alpha RXRA 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0054
629 Alpha-2B adrenergic receptor ADRA2B 0.0054
4252 Penicillin-binding protein 5 dacA 0.0053
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0052
159 Penicillin-binding protein 2B penA 0.0052
6121 Penicillin-binding protein 2B penA 0.0052
1313 Lactoylglutathione lyase GLO1 0.0052
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0051
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
489 Monocarboxylate transporter 2 SLC16A7 0.0051
378 Alpha-2C adrenergic receptor ADRA2C 0.0051
6102 Arylamine N-acetyltransferase 2 NAT2 0.005
380 Cytochrome P450 17A1 CYP17A1 0.005
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.005
450 Muscarinic acetylcholine receptor M4 CHRM4 0.005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
1039 Histone deacetylase 9 HDAC9 0.0048
766 Beta-2 adrenergic receptor ADRB2 0.0048
365 Dihydrofolate reductase DHFR 0.0048
2381 Dihydrofolate reductase DFR1 0.0048
2833 Dihydrofolate reductase Not Available 0.0048
2931 Dihydrofolate reductase folA 0.0048
3544 Dihydrofolate reductase folA 0.0048
3682 Dihydrofolate reductase folA 0.0048
6642 Dihydrofolate reductase folA 0.0048
6756 Dihydrofolate reductase dfrA 0.0048
1050 Bile salt sulfotransferase SULT2A1 0.0047
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0047
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0046
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0046
713 Sodium-dependent dopamine transporter SLC6A3 0.0046
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
707 72 kDa type IV collagenase MMP2 0.0046
284 DNA-directed RNA polymerase beta chain rpoB 0.0046
5773 DNA-directed RNA polymerase beta chain rpoB 0.0046
885 5-hydroxytryptamine 1B receptor HTR1B 0.0046
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0046
1852 Microtubule-associated protein 2 MAP2 0.0046
4226 Uridine phosphorylase 2 UPP2 0.0045
1792 Tissue-type plasminogen activator PLAT 0.0045
768 FK506-binding protein 1A FKBP1A 0.0045
465 Calmodulin CALM1 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
638 D(3) dopamine receptor DRD3 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
725 5-hydroxytryptamine 1D receptor HTR1D 0.0043
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0043
3587 Gastrotropin FABP6 0.0043
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0042
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0042
6501 Fatty acid-binding protein, liver FABP1 0.0042
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0042
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0042
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0041
4225 Uridine phosphorylase 1 UPP1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0041
1714 Mitogen-activated protein kinase 3 MAPK3 0.0041
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0041
408 Riboflavin kinase RFK 0.0041
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0041
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0041
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0041
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0041
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0039
413 Amidophosphoribosyltransferase PPAT 0.0039
2515 Amidophosphoribosyltransferase purF 0.0039
3714 Amidophosphoribosyltransferase purF 0.0039
5924 Microtubule-associated protein 4 MAP4 0.0039
5923 Microtubule-associated protein tau MAPT 0.0039
5482 Sialidase-2 NEU2 0.0039
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0039
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0039
193 Beta-1 adrenergic receptor ADRB1 0.0039
634 Squalene monooxygenase SQLE 0.0039
7196 Squalene monooxygenase ERG1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0038
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
436 5-hydroxytryptamine 2B receptor HTR2B 0.0037
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0036
6182 Cytochrome P450 2J2 CYP2J2 0.0036
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0036
199 Monocarboxylate transporter 8 SLC16A2 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
856 Vitamin D3 receptor VDR 0.0035
997 Protein kinase C beta type PRKCB 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
1025 Aquaporin-1 AQP1 0.0035
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0035
939 50S ribosomal protein L3 rplC 0.0035
432 D(4) dopamine receptor DRD4 0.0035
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0035
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0035
6151 Monocarboxylate transporter 10 SLC16A10 0.0035
1656 CYP2B protein CYP2B 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
3810 Catechol O-methyltransferase COMT 0.0034
716 5-hydroxytryptamine 7 receptor HTR7 0.0033
474 Acetylcholinesterase ACHE 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0033
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0033
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0033
814 Ryanodine receptor 1 RYR1 0.0033
268 Adenosine A2b receptor ADORA2B 0.0033
6677 Myelin P2 protein PMP2 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
595 Fibrinogen alpha chain FGA 0.0032
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.003
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.003
5787 Angiopoietin-1 receptor TEK 0.003
654 Flavin reductase BLVRB 0.0029
6103 Arylamine N-acetyltransferase 1 NAT1 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
2391 Ferrochelatase hemH 0.0029
6502 Ferrochelatase DKFZp686P18130 0.0029
1591 Ferrochelatase, mitochondrial FECH 0.0029
780 Retinoic acid receptor RXR-gamma RXRG 0.0029
33 Cystine/glutamate transporter SLC7A11 0.0029
2236 Casein kinase II subunit alpha CSNK2A1 0.0029
504 Mast/stem cell growth factor receptor KIT 0.0029
571 Melatonin receptor type 1A MTNR1A 0.0028
362 Melatonin receptor type 1B MTNR1B 0.0028
233 Potassium channel subfamily K member 2 KCNK2 0.0028
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0028
1517 Beta-3 adrenergic receptor ADRB3 0.0028
1525 Heparin-binding growth factor 2 FGF2 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1196 Complement decay-accelerating factor CD55 0.0027
5126 Arginase rocF 0.0027
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0027
88 Retinoic acid receptor RXR-beta RXRB 0.0027
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0027
4210 Toll-like receptor 4 TLR4 0.0026
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
822 Aldose reductase AKR1B1 0.0026
3809 Estrogen-related receptor gamma ESRRG 0.0026
49 Endothelin B receptor EDNRB 0.0026
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0026
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0026
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0026
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
407 Vascular endothelial growth factor receptor 2 KDR 0.0025
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
163 D(1B) dopamine receptor DRD5 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2808 Chloramphenicol acetyltransferase 3 cat3 0.0024
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
1992 Vitamin D-binding protein GC 0.0024
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0024
6168 Solute carrier family 22 member 16 SLC22A16 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0023
2540 Choloylglycine hydrolase cbh 0.0023
228 Beta platelet-derived growth factor receptor PDGFRB 0.0023
777 Tumor necrosis factor TNF 0.0023
1291 cAMP response element-binding protein CREB1 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0022
737 Mineralocorticoid receptor NR3C2 0.0022
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
2417 Chloramphenicol acetyltransferase cat 0.0022
3278 Chloramphenicol acetyltransferase cat 0.0022
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0022
2810 Dr hemagglutinin structural subunit draA 0.0022
6220 Aryl hydrocarbon receptor AHR 0.0022
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
904 Glutathione S-transferase P GSTP1 0.0021
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
1256 5-hydroxytryptamine 6 receptor HTR6 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
3957 Adenosine deaminase ADA 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
5934 Cytochrome P450 26A1 CYP26A1 0.0021
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
6432 Transporter snf 0.002
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.002
1618 High affinity nerve growth factor receptor NTRK1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2499 Tubulin beta-2C chain TUBB2C 0.0019
517 Alcohol dehydrogenase 1C ADH1C 0.0019
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0019
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
6500 Phospholipase A2 PLA2G1B 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
4120 NADPH--cytochrome P450 reductase POR 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
26 Vascular endothelial growth factor receptor 3 FLT4 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
683 Potassium transporter GK0582 0.0018
2207 Rhodopsin RHO 0.0018
162 Retinoic acid receptor gamma-1 RARG 0.0018
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
32 Vascular endothelial growth factor receptor 1 FLT1 0.0017
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0016
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
528 5-hydroxytryptamine 1E receptor HTR1E 0.0016
173 Toll-like receptor 7 TLR7 0.0016
1192 Sulfotransferase 1A1 SULT1A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
3939 Amine oxidase [flavin-containing] B MAOB 0.0015
427 Substance-P receptor TACR1 0.0015
1629 Transcription factor AP-1 JUN 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0015
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0015
1541 Metalloproteinase mmp20 0.0014
2693 Heat-labile enterotoxin B chain eltB 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
3937 Fatty-acid amide hydrolase FAAH 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
6645 D-amino-acid oxidase DAO 0.0014
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0014
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0013
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0013
1275 Estrogen sulfotransferase SULT1E1 0.0013
6459 Glycodelin PAEP 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0012
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0012
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
1864 RET proto-oncogene RET 0.0012
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0012
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0012
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0012
1295 Fatty acid synthase FASN 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0011
1268 Neuropeptide S receptor NPSR1 0.0011
239 Coagulation factor X F10 0.0011
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0011
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.0011
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0011
3673 Fumarate reductase flavoprotein subunit fccA 0.0011
4912 Fumarate reductase flavoprotein subunit ifcA 0.0011
6549 Fumarate reductase flavoprotein subunit frdA 0.0011
921 Glutamate receptor 2 GRIA2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
54 Prothrombin F2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
6073 Potassium channel subfamily K member 9 KCNK9 0.001
6072 Potassium channel subfamily K member 3 KCNK3 0.001
1144 Hepatocyte growth factor receptor MET 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
165 FL cytokine receptor FLT3 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
518 Peroxidase/catalase T katG 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
2298 Cytochrome P450-cam camC 0.0008
2232 Interleukin-5 IL5 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
469 Annexin A1 ANXA1 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
164 Histamine H4 receptor HRH4 0.0007
125 DNA polymerase beta POLB 0.0007
4311 tRNA TRDMT1 0.0007
4325 tRNA trmD 0.0007
4328 tRNA trmD 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0006
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0006
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0006
563 Thyroid peroxidase TPO 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
7 Nitric oxide synthase, inducible NOS2 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1341 Histamine H3 receptor HRH3 0.0005
84 Nuclear receptor 0B1 NR0B1 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
823 Fibroblast growth factor receptor 2 FGFR2 0.0005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
5961 Insulin INS 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
6755 Poliovirus receptor PVR 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
319 Opioid receptor, sigma 1 OPRS1 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1630 Integrin beta-2 ITGB2 0.0004
976 Platelet glycoprotein IX GP9 0.0004
291 Nitric-oxide synthase, endothelial NOS3 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
4943 Cytochrome c6 petJ 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
5000 HemO hemO 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4984 Neuroglobin NGB 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4935 Cytochrome c-554 cycA1 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
3116 Bacterioferritin bfr 0.0004
4906 Bacterioferritin bfr 0.0004
4965 Bacterioferritin bfr 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4961 Hemophore HasA hasA 0.0004
4909 CooA protein cooA 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4972 P450cin cinA 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4952 Catalase/peroxidase katA 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
3093 Catalase HPII katE 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
174 Sigma 1-type opioid receptor SIGMAR1 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
6044 Serum paraoxonase/lactonase 3 PON3 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
572 Integrin alpha-L ITGAL 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0003
4920 Peroxidase/catalase katG 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
908 Glutathione S-transferase theta-1 GSTT1 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0001
↑