DT-Web

DB00656 - Trazodone


Identification
Name Trazodone
Accession Number DB00656 (APRD00533)
Type small molecule
Description A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 371.864
Groups approved
Monoisotopic Weight 371.151288058
Pharmacology
Indication For the treatment of depression.
Mechanism of action Trazodone binds at 5-HT2 receptor, it acts as a serotonin agonist at high doses and a serotonin antagonist at low doses. Like fluoxetine, trazodone's antidepressant activity likely results from blockage of serotonin reuptake by inhibiting serotonin reuptake pump at the presynaptic neuronal membrane. If used for long time periods, postsynaptic neuronal receptor binding sites may also be affected. The sedative effect of trazodone is likely the result of alpha-adrenergic blocking action and modest histamine blockade at H1 receptor. It weakly blocks presynaptic alpha2-adrenergic receptors and strongly inhibits postsynaptic alpha1 receptors. Trazodone does not affect the reuptake of norepinephrine or dopamine within the CNS.
Absorption Rapidly and almost completely absorbed following oral administration. Food may decrease the rate and extent of absorption.
Protein binding 89-95% bound to plasma proteins in vitro
Biotransformation Undergoes extensive hepatic metabolism via hydroxylation, N-dealkylation, N-oxidation and splitting of the pyridine ring. Cytochrome P450 (CYP) 3A4 catalyzes the formation of the major active metabolite, m-chlorophenylpiperazine (m-CPP). Metabolites may be further conjugated to glucuonic acid or glutathione. CYP2D6 is responsible for 4'-hydroxylation of m-CPP and the formation of at least one glutathione conjugates of m-CPP, a quinone imine-sulhydryl adduct. Oxotriazolopyridinpropionic acid, an inactive metabolite, and its conjugates account for about 20% of the total excreted oral dose. Less than 1% of the oral dose is excreted unchanged. Approximately 70-75% of the dose is eliminated in urine with the remainder being excreted in feces via biliary elimination.
Route of elimination Not Available
Toxicity LD50=96mg/kg (i.v. in mice)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Almotriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Aminoglutethimide The CYP3A4 inducer, Aminoglutethimide, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Aminoglutethimide is initiated, discontinued or dose changed.
Amiodarone The CYP3A4 inhibitor, Amiodarone, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Amiodarone is initiated, discontinued or dose changed.
Amitriptyline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Amoxapine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Amprenavir The protease inhibitor, Amprenavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Amprenavir is initiated, discontinued or dose changed.
Aprepitant The CYP3A4 inhibitor, Aprepitant, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Aprepitant is initiated, discontinued or dose changed.
Atazanavir The protease inhibitor, Atazanavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Atazanavir is initiated, discontinued or dose changed.
Bosentan The CYP3A4 inducer, Bosentan, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Bosentan is initiated, discontinued or dose changed.
Bromocriptine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Buspirone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Cabergoline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Carbamazepine The CYP3A4 inducer, Carbamazepine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Carbamazepine is initiated, discontinued or dose changed.
Cimetidine The CYP3A4 inhibitor, Cimetidine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Cimetidine is initiated, discontinued or dose changed.
Citalopram Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Clarithromycin The CYP3A4 inhibitor, Clarithromycin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Clarithromycin is initiated, discontinued or dose changed.
Clomipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Clotrimazole The CYP3A4 inhibitor, Clotrimazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Clotrimazole is initiated, discontinued or dose changed.
Conivaptan The CYP3A4 inhibitor, Conivaptan, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Conivaptan is initiated, discontinued or dose changed.
Cyclosporine The CYP3A4 inhibitor, Cyclosporine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Cyclosporine is initiated, discontinued or dose changed.
Dabigatran etexilate P-Glycoprotein inducers such as trazodone may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Darunavir The protease inhibitor, Darunavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Darunavir is initiated, discontinued or dose changed.
Delavirdine The CYP3A4 inhibitor, Delavirdine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Delavirdine is initiated, discontinued or dose changed.
Desipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dexamethasone The CYP3A4 inducer, Dexamethasone, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Dexamethasone is initiated, discontinued or dose changed.
Dextromethorphan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroergotamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Diltiazem The CYP3A4 inhibitor, Diltizem, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Diltiazem is initiated, discontinued or dose changed.
Donepezil Possible antagonism of action
Doxepin Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Duloxetine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Efavirenz The CYP3A4 inhibitor and inducer, Efavirenz, may alter Trazodone efficacy/toxicity by altering Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Efavirenz is initiated, discontinued or dose changed.
Eletriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ergoloid mesylate Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ergonovine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Ergotamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Erythromycin The CYP3A4 inhibitor, Erythromycin , may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Erythromycin is initiated, discontinued or dose changed.
Escitalopram Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Etravirine The CYP3A4 inducer, Etravirene, may decrease Trazodone efficacy/toxicity by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Etravirine is initiated, discontinued or dose changed.
Fluconazole The CYP3A4 inhibitor, Fluconazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Fluconazole is initiated, discontinued or dose changed.
Fluoxetine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Fluvoxamine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Fosamprenavir The protease inhibitor, Fosamprenavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Fosamprenavir is initiated, discontinued or dose changed.
Fosphenytoin The CYP3A4 inducer, Fosphenytoin, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Fosphenytoin is initiated, discontinued or dose changed.
Frovatriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Furazolidone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Galantamine Possible antagonism of action
Ginkgo biloba Increased effect and toxicity of both agents
Haloperidol The CYP3A4 inhibitor, Haloperidol, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. The CYP2D6 inhibitor, Trazodone, may increase the efficacy of Haloperidol by decreasing Haloperidol metabolism and clearance. Monitor for changes in Trazodone and Haloperidol efficacy/toxicity if either agent is initiated, discontinued or dose changed.
Imatinib The CYP3A4 inhibitor, Imatinib, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Imatinib is initiated, discontinued or dose changed.
Imipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Indinavir The protease inhibitor, Indinavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism via CYP3A4. Monitor for changes in Trazodone efficacy/toxicity if Indinavir is initiated, discontinued or dose changed.
Isocarboxazid Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Isoniazid The CYP3A4 inhibitor, Isoniazid, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Isoniazid is initiated, discontinued or dose changed.
Itraconazole The CYP3A4 inhibitor, Itraconazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Itraconazole is initiated, discontinued or dose changed.
Ketoconazole The CYP3A4 inhibitor, Ketoconazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Ketoconazole is initiated, discontinued or dose changed.
Lapatinib The CYP3A4 inhibitor, Lapatinib, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Lapatinib is initiated, discontinued or dose changed.
Lidocaine The CYP3A4 inhibitor, Lidocaine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Lidocaine is initiated, discontinued or dose changed.
Linezolid Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Lithium Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Lopinavir The protease inhibitor, Lopinavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Lopinavir is initiated, discontinued or dose changed.
Maprotiline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Meperidine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Methylergonovine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Metronidazole The CYP3A4 inhibitor, Metronidazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Metronidazole is initiated, discontinued or dose changed.
Miconazole The CYP3A4 inhibitor, Miconazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Miconazole is initiated, discontinued or dose changed.
Mirtazapine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Moclobemide Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Nafcillin The CYP3A4 inducer, Nafcillin, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Nafcillin is initiated, discontinued or dose changed.
Naratriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Nefazodone Increased risk of serotonin syndrome. The CYP3A4 inhibitor, Nefazodone, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for symtpoms of sertonin syndrome and changes in Trazodone efficacy/toxicity if Nefazodone is initiated, discontinued or dose changed.
Nelfinavir The protease inhibitor, Nelfinavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Nelfinavir is initiated, discontinued or dose changed.
Nevirapine The CYP3A4 inducer, Nevirapine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Nevirapine is initiated, discontinued or dose changed.
Nicardipine The CYP3A4 inhibitor, Nicardipine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Nicardipine is initiated, discontinued or dose changed.
Norfloxacin The CYP3A4 inhibitor, Norfloxacin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Norfloxacin is initiated, discontinued or dose changed.
Nortriptyline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Oxcarbazepine The CYP3A4 inducer, Oxcarbazepine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Oxcarbazepine is initiated, discontinued or dose changed.
Paroxetine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Pentobarbital The CYP3A4 inducer, Pentobarbital, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Pentobarbital is initiated, discontinued or dose changed.
Pergolide Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Phenelzine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Phenobarbital The CYP3A4 inducer, Phenobarbital, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Phenobarbital is initiated, discontinued or dose changed.
Phenytoin The CYP3A4 inducer, Phenytoin, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Phenytoin is initiated, discontinued or dose changed.
Posaconazole The CYP3A4 inhibitor, Posaconazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Posaconazole is initiated, discontinued or dose changed.
Primidone The CYP3A4 inducer, Primidone, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Primidone is initiated, discontinued or dose changed.
Procarbazine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Promethazine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Protriptyline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Quinidine The CYP3A4 inhibitor, Quinidine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Quinidine is initiated, discontinued or dose changed.
Rasagiline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Rifabutin The CYP3A4 inducer, Rifabutin, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Rifabutin is initiated, discontinued or dose changed.
Rifampin The CYP3A4 inducer, Rifampin, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Rifampin is initiated, discontinued or dose changed.
Rifapentine The CYP3A4 inducer, Rifapentine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Rifapentine is initiated, discontinued or dose changed.
Ritonavir The protease inhibitor, Ritonavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Ritonavir is initiated, discontinued or dose changed.
Rivastigmine Possible antagonism of action
Rizatriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
S-Adenosylmethionine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Saquinavir The protease inhibitor, Saquinavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Saquinavir is initiated, discontinued or dose changed.
Selegiline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Sertraline Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Sibutramine Increased risk of serotonin syndrome. Avoid concomitant therapy.
Sitaxentan The CYP3A4 inhibitor, Sitaxsenten, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Norfloxacin is initiated, discontinued or dose changed.
St. John's Wort Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Sumatriptan Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tamoxifen Trazodone may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Trazodone, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Trazodone is initiated, discontinued, or dose changed.
Telithromycin The CYP3A4 inhibitor, Telithromycin, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Telithromycin is initiated, discontinued or dose changed.
Tetracycline The CYP3A4 inhibitor, Tetracycline, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Tetracycline is initiated, discontinued or dose changed.
Tipranavir The protease inhibitor, Tipranavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Tipranavir is initiated, discontinued or dose changed.
Tramadol The use of two serotonin modulators, such as trazodone and tramadol, may increase the risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trimipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Triprolidine The CNS depressants, Triprolidine and Trazodone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Verapamil The CYP3A4 inhibitor, Verapamil, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Verapamil is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of trazodone by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of trazodone if voriconazole is initiated, discontinued or dose changed.
Zolmitriptan Use of two serotonin modulators, such as zolmitriptan and trazodone, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Food Interactions
  • Food decreases the rate and extent of absorption.
  • Avoid alcohol.

Targets


5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Pazzagli M, Giovannini MG, Pepeu G: Trazodone increases extracellular serotonin levels in the frontal cortex of rats. Eur J Pharmacol. 1999 Nov 3;383(3):249-57. - Pubmed
  • Marcoli M, Rosu C, Bonfanti A, Raiteri M, Maura G: Inhibitory presynaptic 5-hydroxytryptamine(2A) receptors regulate evoked glutamate release from rat cerebellar mossy fibers. J Pharmacol Exp Ther. 2001 Dec;299(3):1106-11. - Pubmed
  • Marek GJ, McDougle CJ, Price LH, Seiden LS: A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action. Psychopharmacology (Berl). 1992;109(1-2):2-11. - Pubmed
  • Luparini MR, Garrone B, Pazzagli M, Pinza M, Pepeu G: A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Nov;28(7):1117-27. - Pubmed
  • Conn PJ, Sanders-Bush E: Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7. - Pubmed
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score 0.4562
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action yes
Actions agonist
References
  • Fiorella D, Rabin RA, Winter JC: The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine. Psychopharmacology (Berl). 1995 May;119(2):222-30. - Pubmed
  • Conn PJ, Sanders-Bush E: Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7. - Pubmed
DTHybrid score 0.3278
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions inhibitor
References
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.3827
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action yes
Actions partial agonist
References
  • Odagaki Y, Toyoshima R, Yamauchi T: Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. J Psychopharmacol. 2005 May;19(3):235-41. - Pubmed
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
  • Subhash MN, Srinivas BN, Vinod KY: Alterations in 5-HT(1A) receptors and adenylyl cyclase response by trazodone in regions of rat brain. Life Sci. 2002 Aug 16;71(13):1559-67. - Pubmed
DTHybrid score 0.3868
Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action unknown
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Richelson E, Nelson A: Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro. J Pharmacol Exp Ther. 1984 Jul;230(1):94-102. - Pubmed
  • Noguchi S, Inukai T, Kuno T, Tanaka C: The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking. Physiol Behav. 1992 Jun;51(6):1123-7. - Pubmed
DTHybrid score 0.6695
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action no
Actions antagonist
References
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score 0.5532
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action no
Actions antagonist
References
  • Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4908

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Rotzinger S, Fang J, Baker GB: Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources. Drug Metab Dispos. 1998 Jun;26(6):572-5. - Pubmed
  • Kalgutkar AS, Henne KR, Lame ME, Vaz AD, Collin C, Soglia JR, Zhao SX, Hop CE: Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4. Chem Biol Interact. 2005 Jun 30;155(1-2):10-20. Epub 2005 Apr 18. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8439
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.4482
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.3585
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Wen B, Ma L, Rodrigues AD, Zhu M: Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine. Drug Metab Dispos. 2008 May;36(5):841-50. Epub 2008 Jan 31. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7497

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inducer
References
  • Stormer E, von Moltke LL, Perloff MD, Greenblatt DJ: P-glycoprotein interactions of nefazodone and trazodone in cell culture. J Clin Pharmacol. 2001 Jul;41(7):708-14. - Pubmed
DTHybrid score 0.5376

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.5376

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.3437
4757 Cytochrome P450 2C9 CYP2C9 0.2986
831 D(2) dopamine receptor DRD2 0.2962
6016 Cytochrome P450 2C19 CYP2C19 0.294
540 Sodium-dependent noradrenaline transporter SLC6A2 0.2908
23 D(1A) dopamine receptor DRD1 0.2345
632 Alpha-1B adrenergic receptor ADRA1B 0.2239
4924 Cytochrome P450 2C8 CYP2C8 0.2093
378 Alpha-2C adrenergic receptor ADRA2C 0.1887
629 Alpha-2B adrenergic receptor ADRA2B 0.1885
6030 Cytochrome P450 2B6 CYP2B6 0.1813
713 Sodium-dependent dopamine transporter SLC6A3 0.1731
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1717
436 5-hydroxytryptamine 2B receptor HTR2B 0.1564
587 Serum albumin ALB 0.1548
638 D(3) dopamine receptor DRD3 0.1496
6013 Cytochrome P450 2E1 CYP2E1 0.1482
885 5-hydroxytryptamine 1B receptor HTR1B 0.1417
789 Alpha-1D adrenergic receptor ADRA1D 0.1391
432 D(4) dopamine receptor DRD4 0.1345
725 5-hydroxytryptamine 1D receptor HTR1D 0.1327
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1206
617 Muscarinic acetylcholine receptor M2 CHRM2 0.1187
766 Beta-2 adrenergic receptor ADRB2 0.1172
716 5-hydroxytryptamine 7 receptor HTR7 0.1115
193 Beta-1 adrenergic receptor ADRB1 0.1109
6024 Cytochrome P450 1A1 CYP1A1 0.1085
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1065
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1037
6145 Solute carrier family 22 member 1 SLC22A1 0.103
163 D(1B) dopamine receptor DRD5 0.1012
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0981
3941 Amine oxidase [flavin-containing] A MAOA 0.0911
5718 Cytochrome P450 2A6 CYP2A6 0.0812
131 Synaptic vesicular amine transporter SLC18A2 0.0766
6144 Solute carrier family 22 member 2 SLC22A2 0.0719
1256 5-hydroxytryptamine 6 receptor HTR6 0.069
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0675
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0646
862 Multidrug resistance-associated protein 1 ABCC1 0.0617
341 5-hydroxytryptamine 3 receptor HTR3A 0.0606
6106 Cytochrome P450 2C18 CYP2C18 0.0598
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0589
847 Mu-type opioid receptor OPRM1 0.0588
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0585
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0528
696 Kappa-type opioid receptor OPRK1 0.0517
3939 Amine oxidase [flavin-containing] B MAOB 0.0504
94 5-hydroxytryptamine 4 receptor HTR4 0.0476
118 Organic cation/carnitine transporter 2 SLC22A5 0.0464
20 Prostaglandin G/H synthase 1 PTGS1 0.0452
467 Delta-type opioid receptor OPRD1 0.0448
6147 Solute carrier family 22 member 3 SLC22A3 0.0422
1656 CYP2B protein CYP2B 0.0412
528 5-hydroxytryptamine 1E receptor HTR1E 0.0396
776 Bile salt export pump ABCB11 0.0392
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0392
871 Glucocorticoid receptor NR3C1 0.0384
465 Calmodulin CALM1 0.0381
3923 Cholinesterase BCHE 0.0377
124 Histamine H2 receptor HRH2 0.0372
1898 Cytochrome P450 1B1 CYP1B1 0.0364
1517 Beta-3 adrenergic receptor ADRB3 0.0349
1729 Solute carrier family 22 member 6 SLC22A6 0.0344
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0331
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0324
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0323
833 Organic cation/carnitine transporter 1 SLC22A4 0.0323
6182 Cytochrome P450 2J2 CYP2J2 0.0317
6031 Cytochrome P450 3A43 CYP3A43 0.0316
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0316
3811 Cytochrome P450 19A1 CYP19A1 0.0305
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0299
731 HIV-1 protease HIV-1 protease 0.0288
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0281
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0275
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0268
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0265
474 Acetylcholinesterase ACHE 0.0264
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0262
844 Epidermal growth factor receptor EGFR 0.0252
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0249
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0247
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0242
511 5-hydroxytryptamine 1F receptor HTR1F 0.0241
6432 Transporter snf 0.0238
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0235
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0229
174 Sigma 1-type opioid receptor SIGMAR1 0.0223
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0219
2164 Multidrug resistance-associated protein 4 ABCC4 0.0218
6143 Solute carrier family 22 member 7 SLC22A7 0.0217
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0214
614 Progesterone receptor PGR 0.0212
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.021
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.021
817 DNA topoisomerase 2-alpha TOP2A 0.0209
136 Estrogen receptor ESR1 0.0206
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0206
260 Cytochrome P450 51 ERG11 0.0204
761 Cytochrome P450 51 ERG11 0.0204
3163 Cytochrome P450 51 cyp51 0.0204
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0197
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0193
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0193
1341 Histamine H3 receptor HRH3 0.0189
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0189
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0188
6148 Multidrug resistance-associated protein 7 ABCC10 0.0187
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0186
6142 Solute carrier family 22 member 8 SLC22A8 0.0186
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0184
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
290 Prostaglandin G/H synthase 2 PTGS2 0.0181
737 Mineralocorticoid receptor NR3C2 0.0175
4120 NADPH--cytochrome P450 reductase POR 0.0174
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0171
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0171
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
232 Corticosteroid-binding globulin SERPINA6 0.0166
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0164
380 Cytochrome P450 17A1 CYP17A1 0.0163
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0162
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0161
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0156
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0155
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0152
504 Mast/stem cell growth factor receptor KIT 0.0152
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0147
768 FK506-binding protein 1A FKBP1A 0.0143
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0139
1618 High affinity nerve growth factor receptor NTRK1 0.0139
6020 Aldehyde oxidase AOX1 0.0139
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0137
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0136
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0136
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0135
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0135
3426 Glutamine synthetase glnA 0.0133
3987 Glutamine synthetase GLUL 0.0133
468 Cytochrome P450 4A11 CYP4A11 0.0132
4604 Liver carboxylesterase 1 CES1 0.0131
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0131
756 Sex hormone-binding globulin SHBG 0.0131
1636 Trace amine-associated receptor 1 TAAR1 0.013
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
228 Beta platelet-derived growth factor receptor PDGFRB 0.0125
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0124
818 50S ribosomal protein L10 rplJ 0.0122
952 Dipeptidyl peptidase 4 DPP4 0.0121
161 Tubulin beta chain TUBB 0.0119
312 Tubulin beta chain TUB2 0.0119
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0117
6141 Sodium/bile acid cotransporter SLC10A1 0.0117
811 Translocator protein TSPO 0.0116
362 Melatonin receptor type 1B MTNR1B 0.0115
571 Melatonin receptor type 1A MTNR1A 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0112
1050 Bile salt sulfotransferase SULT2A1 0.0112
29 Tubulin beta-1 chain TUBB1 0.0111
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0111
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0111
477 DNA topoisomerase 4 subunit A parC 0.0109
886 DNA topoisomerase 4 subunit A parC 0.0109
6226 DNA topoisomerase 4 subunit A parC 0.0109
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0109
26 Vascular endothelial growth factor receptor 3 FLT4 0.0108
404 DNA gyrase subunit A gyrA 0.0108
6224 DNA gyrase subunit A gyrA 0.0108
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0107
828 Phenylalanine-4-hydroxylase PAH 0.0107
3109 Phenylalanine-4-hydroxylase phhA 0.0107
407 Vascular endothelial growth factor receptor 2 KDR 0.0106
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0105
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0105
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0105
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0105
32 Vascular endothelial growth factor receptor 1 FLT1 0.0103
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0103
6137 Multidrug resistance-associated protein 6 ABCC6 0.0102
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0101
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0101
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0101
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0101
164 Histamine H4 receptor HRH4 0.0101
146 Androgen receptor AR 0.01
3810 Catechol O-methyltransferase COMT 0.01
904 Glutathione S-transferase P GSTP1 0.01
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0099
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0098
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0098
1275 Estrogen sulfotransferase SULT1E1 0.0098
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0095
4237 50S ribosomal protein L22 rplV 0.0095
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0093
3947 Xanthine dehydrogenase/oxidase XDH 0.0093
122 P2Y purinoceptor 12 P2RY12 0.0092
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0091
319 Opioid receptor, sigma 1 OPRS1 0.0091
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0091
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0091
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0091
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0091
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0091
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.009
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.009
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.009
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0089
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0088
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0087
1360 Sphingomyelin phosphodiesterase SMPD1 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
777 Tumor necrosis factor TNF 0.0087
6136 Multidrug resistance-associated protein 5 ABCC5 0.0086
6138 Multidrug resistance protein 3 ABCB4 0.0086
738 Monocarboxylate transporter 1 SLC16A1 0.0085
1010 Cytochrome P450 51A1 CYP51A1 0.0085
6220 Aryl hydrocarbon receptor AHR 0.0085
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0083
869 Estrogen receptor beta ESR2 0.0083
4238 50S ribosomal protein L4 rplD 0.0083
5578 50S ribosomal protein L4 rplD 0.0083
6173 50S ribosomal protein L4 rplD 0.0083
6219 50S ribosomal protein L4 rplD 0.0083
1757 Myeloperoxidase MPO 0.0082
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0082
1192 Sulfotransferase 1A1 SULT1A1 0.0082
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0081
1024 Solute carrier family 22 member 11 SLC22A11 0.008
2112 Toll-like receptor 9 TLR9 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
1852 Microtubule-associated protein 2 MAP2 0.0079
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0079
5787 Angiopoietin-1 receptor TEK 0.0078
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0078
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0078
183 Vascular endothelial growth factor A VEGFA 0.0077
244 Angiotensin-converting enzyme ACE 0.0076
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0076
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0076
2539 Tubulin alpha-1 chain TUBA4A 0.0076
923 Glutamate receptor 3 GRIA3 0.0075
6070 Nischarin NISCH 0.0075
165 FL cytokine receptor FLT3 0.0075
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0075
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0075
4203 Histamine N-methyltransferase HNMT 0.0075
427 Substance-P receptor TACR1 0.0074
208 DNA-directed RNA polymerase beta' chain rpoC 0.0074
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0074
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0073
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0073
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0073
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0073
705 Glutamate receptor 1 GRIA1 0.0072
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0071
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.007
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0069
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0068
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0067
814 Ryanodine receptor 1 RYR1 0.0067
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0067
921 Glutamate receptor 2 GRIA2 0.0067
70 Type-1 angiotensin II receptor AGTR1 0.0066
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0064
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
469 Annexin A1 ANXA1 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
2449 Tubulin alpha-3 chain TUBA1A 0.0062
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0062
1178 Adenosine A2a receptor ADORA2A 0.0062
6097 Protein S100-A2 S100A2 0.006
1810 Protein S100-A1 S100A1 0.006
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0059
233 Potassium channel subfamily K member 2 KCNK2 0.0059
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0059
5923 Microtubule-associated protein tau MAPT 0.0059
5924 Microtubule-associated protein 4 MAP4 0.0059
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
239 Coagulation factor X F10 0.0058
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
373 Transthyretin TTR 0.0056
273 Apoptosis regulator Bcl-2 BCL2 0.0056
6506 Stathmin-4 STMN4 0.0055
4773 Deoxycytidine kinase DCK 0.0055
6102 Arylamine N-acetyltransferase 2 NAT2 0.0054
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0053
1864 RET proto-oncogene RET 0.0053
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0053
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0053
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0053
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0052
1048 Protein S100-A13 S100A13 0.0052
2226 Protein S100-A12 S100A12 0.0052
5300 Antigen peptide transporter 1 TAP1 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
295 Carbonic anhydrase 1 CA1 0.005
3932 Glutathione S-transferase A2 GSTA2 0.005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0049
2132 Protein S100-B S100B 0.0049
173 Toll-like receptor 7 TLR7 0.0049
1483 Membrane copper amine oxidase AOC3 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0048
6014 Cytochrome P450 2A13 CYP2A13 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
6859 Protein S100-A4 S100A4 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0046
3086 Plasmepsin-2 Not Available 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
68 Cannabinoid receptor 1 CNR1 0.0045
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0045
54 Prothrombin F2 0.0045
1629 Transcription factor AP-1 JUN 0.0045
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0045
16 Adenosine A1 receptor ADORA1 0.0044
84 Nuclear receptor 0B1 NR0B1 0.0044
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0044
284 DNA-directed RNA polymerase beta chain rpoB 0.0044
5773 DNA-directed RNA polymerase beta chain rpoB 0.0044
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0044
365 Dihydrofolate reductase DHFR 0.0044
2381 Dihydrofolate reductase DFR1 0.0044
2833 Dihydrofolate reductase Not Available 0.0044
2931 Dihydrofolate reductase folA 0.0044
3544 Dihydrofolate reductase folA 0.0044
3682 Dihydrofolate reductase folA 0.0044
6642 Dihydrofolate reductase folA 0.0044
6756 Dihydrofolate reductase dfrA 0.0044
4122 Histone deacetylase 2 HDAC2 0.0043
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
1196 Complement decay-accelerating factor CD55 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
1630 Integrin beta-2 ITGB2 0.0041
976 Platelet glycoprotein IX GP9 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
856 Vitamin D3 receptor VDR 0.004
751 Potassium channel subfamily K member 6 KCNK6 0.004
3856 Fibroblast growth factor receptor 3 FGFR3 0.004
6151 Monocarboxylate transporter 10 SLC16A10 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
592 Carbonic anhydrase 4 CA4 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0037
4311 tRNA TRDMT1 0.0037
4325 tRNA trmD 0.0037
4328 tRNA trmD 0.0037
823 Fibroblast growth factor receptor 2 FGFR2 0.0037
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
172 Potassium channel subfamily K member 1 KCNK1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0036
2808 Chloramphenicol acetyltransferase 3 cat3 0.0036
153 Dopamine beta-hydroxylase DBH 0.0036
1374 Natriuretic peptides B NPPB 0.0036
1827 Gap junction alpha-1 protein GJA1 0.0036
1908 Vascular cell adhesion protein 1 VCAM1 0.0036
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
6048 Troponin C, skeletal muscle TNNC2 0.0035
780 Retinoic acid receptor RXR-gamma RXRG 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6085 Fatty acid-binding protein, intestinal FABP2 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0034
4103 Proteasome subunit beta type 2 PSMB2 0.0034
4102 Proteasome subunit beta type 5 PSMB5 0.0034
4101 Proteasome subunit beta type 1 PSMB1 0.0034
6044 Serum paraoxonase/lactonase 3 PON3 0.0034
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
3601 Dihydropteroate synthase 1 folP1 0.0033
3807 Dihydropteroate synthase 1 folP1 0.0033
3808 Dihydropteroate synthase 2 folP2 0.0033
2417 Chloramphenicol acetyltransferase cat 0.0033
3278 Chloramphenicol acetyltransferase cat 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0032
2810 Dr hemagglutinin structural subunit draA 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0032
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0032
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0032
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0032
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0032
88 Retinoic acid receptor RXR-beta RXRB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
3913 Glutamic acid decarboxylase GAD65 0.0031
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0031
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0031
572 Integrin alpha-L ITGAL 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
4192 DNA topoisomerase 2-beta TOP2B 0.003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0028
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0028
275 Arachidonate 5-lipoxygenase ALOX5 0.0028
3809 Estrogen-related receptor gamma ESRRG 0.0027
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0027
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0026
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
7 Nitric oxide synthase, inducible NOS2 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
735 Alanine aminotransferase 1 GPT 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
49 Endothelin B receptor EDNRB 0.0026
33 Cystine/glutamate transporter SLC7A11 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0024
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0023
936 Ephrin type-A receptor 2 EPHA2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
1262 Corticotropin-lipotropin POMC 0.0022
162 Retinoic acid receptor gamma-1 RARG 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
581 Cytochrome P450 2R1 CYP2R1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0022
298 Renin REN 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
267 Plasminogen activator inhibitor 1 SERPINE1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
6126 Carbonic anhydrase 7 CA7 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
482 Glycine receptor subunit alpha-1 GLRA1 0.002
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
6221 Steroid hormone receptor ERR1 ESRRA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
908 Glutathione S-transferase theta-1 GSTT1 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0017
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0017
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
518 Peroxidase/catalase T katG 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
6755 Poliovirus receptor PVR 0.0015
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0015
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0015
3957 Adenosine deaminase ADA 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
563 Thyroid peroxidase TPO 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
6146 High affinity copper uptake protein 1 SLC31A1 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0012
1295 Fatty acid synthase FASN 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
1992 Vitamin D-binding protein GC 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6459 Glycodelin PAEP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
3937 Fatty-acid amide hydrolase FAAH 0.001
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4217 Telomerase reverse transcriptase TERT 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
2207 Rhodopsin RHO 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
1648 Elastin ELN 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
2981 Phospholipase A2, membrane associated PLA2G2A 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
6218 Pannexin-1 PANX1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2021 Thrombomodulin THBD 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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