DT-Web

DB00281 - Lidocaine


Identification
Name Lidocaine
Accession Number DB00281 (APRD00479, DB05291)
Type small molecule
Description A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 234.3373
Groups approved
Monoisotopic Weight 234.173213336
Pharmacology
Indication For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Mechanism of action Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. Lidocaine alters signal conduction in neurons by blocking the fast voltage gated sodium (Na+) channels in the neuronal cell membrane that are responsible for signal propagation. With sufficient blockage the membrane of the postsynaptic neuron will not depolarize and will thus fail to transmit an action potential. This creates the anaesthetic effect by not merely preventing pain signals from propagating to the brain but by aborting their birth in the first place.
Absorption Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.
Protein binding 60-80%
Biotransformation Primarily hepatic.
Route of elimination Lidocaine and its metabolites are excreted by the kidneys.
Toxicity The oral LD 50 of lidocaine HCl in non-fasted female rats is 459 (346-773) mg/kg (as the salt) and 214 (159-324) mg/kg (as the salt) in fasted female rats. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol The beta-blocker, acebutolol, may increase the effect and toxicity of lidocaine.
Atazanavir Increased risk of cardiotoxicity and arrhythmias
Atenolol The beta-blocker, atenolol, may increase the effect and toxicity of lidocaine.
Bisoprolol The beta-blocker, bisoprolol, may increase the effect and toxicity of lidocaine.
Carvedilol The beta-blocker, carvedilol, may increase the effect and toxicity of lidocaine.
Cimetidine Increases the effect and toxicity of lidocaine
Darunavir Possible increase in lidocaine levels
Esmolol The beta-blocker, esmolol, may increase the effect and toxicity of lidocaine.
Etravirine Lidocaine, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to monitor lidocaine therapy.
Labetalol The beta-blocker, labetalol, may increase the effect and toxicity of lidocaine.
Metoprolol The beta-blocker, metoprolol, may increase the effect and toxicity of lidocaine
Nadolol The beta-blocker, nadolol, may decrease symptoms of hypoglycemia.
Oxprenolol The beta-blocker increases the effect and toxicity of lidocaine
Penbutolol Penbutolol increases the volume of distribution of lidocaine in normal subjects. This could result in a requirement for higher loading doses of lidocaine.
Pindolol The beta-blocker increases the effect and toxicity of lidocaine
Propranolol The beta-blocker, propranolol, may increase the effect and toxicity of lidocaine.
Quinupristin This combination presents an increased risk of toxicity
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Lidocaine. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Lidocaine is initiated, discontinued or if the dose is changed.
Tamoxifen Lidocaine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Lidocaine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Lidocaine is initiated, discontinued, or dose changed.
Telithromycin Telithromycin may reduce clearance of Lidocaine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Lidocaine if Telithromycin is initiated, discontinued or dose changed.
Terbinafine Terbinafine may reduce the metabolism and clearance of Lidocaine. Consider alternate therapy or monitor for therapeutic/adverse effects of Lidocaine if Terbinafine is initiated, discontinued or dose changed.
Thiothixene The strong CYP1A2 inhibitor, Lidocaine, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Lidocaine is initiated, discontinued or dose changed.
Timolol The beta-blocker, timolol, may increase the effect and toxicity of lidocaine.
Tizanidine Lidocaine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Tolterodine Lidocaine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Lidocaine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Lidocaine may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The CYP3A4 inhibitor, Lidocaine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Lidocaine is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of lidocaine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of lidocaine if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Sodium channel protein type 10 subunit alpha
Name Sodium channel protein type 10 subunit alpha
Gene Name SCN10A
Pharmacological action yes
Actions inhibitor
References
  • Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ: muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17030-5. Epub 2006 Oct 31. - Pubmed
  • Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. Epub 2008 Dec 15. - Pubmed
  • Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. - Pubmed
DTHybrid score 0.7518
Sodium channel protein type 9 subunit alpha
Name Sodium channel protein type 9 subunit alpha
Gene Name SCN9A
Pharmacological action yes
Actions inhibitor
References
  • Sheets PL, Jackson JO 2nd, Waxman SG, Dib-Hajj SD, Cummins TR: A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. J Physiol. 2007 Jun 15;581(Pt 3):1019-31. Epub 2007 Apr 12. - Pubmed
  • Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. Epub 2008 Dec 15. - Pubmed
  • Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. - Pubmed
DTHybrid score 0.3563
Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Itoh H, Tsuji K, Sakaguchi T, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ashihara T, Ito M, Horie M, Imoto K: A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome. Int J Cardiol. 2007 Oct 18;121(3):239-48. Epub 2007 Apr 18. - Pubmed
  • Fedida D, Orth PM, Hesketh JC, Ezrin AM: The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S71-S78. - Pubmed
  • Wallace CH, Baczko I, Jones L, Fercho M, Light PE: Inhibition of cardiac voltage-gated sodium channels by grape polyphenols. Br J Pharmacol. 2006 Nov;149(6):657-65. Epub 2006 Oct 3. - Pubmed
  • Cerne A, Bergh C, Borg K, Ek I, Gejervall AL, Hillensjo T, Olofsson JI, Stener-Victorin E, Wood M, Westlander G: Pre-ovarian block versus paracervical block for oocyte retrieval. Hum Reprod. 2006 Nov;21(11):2916-21. Epub 2006 Jul 13. - Pubmed
  • Muroi Y, Chanda B: Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol. 2009 Jan;133(1):1-15. Epub 2008 Dec 15. - Pubmed
  • Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A: Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS Comput Biol. 2010 Jun 17;6(6):e1000818. - Pubmed
DTHybrid score 0.6399
Epidermal growth factor receptor
Name Epidermal growth factor receptor
Gene Name EGFR
Pharmacological action unknown
Actions antagonist
References
  • Sakaguchi M, Kuroda Y, Hirose M: The antiproliferative effect of lidocaine on human tongue cancer cells with inhibition of the activity of epidermal growth factor receptor. Anesth Analg. 2006 Apr;102(4):1103-7. - Pubmed
DTHybrid score 0.5745

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. - Pubmed
DTHybrid score 1.0686
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.789
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.5615
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.436
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT: Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65. - Pubmed
DTHybrid score 0.6476
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6885
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5445
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2751
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4022
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4862

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed
DTHybrid score 0.2622
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Wang E, Lew K, Barecki M, Casciano CN, Clement RP, Johnson WW: Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol. 2001 Dec;14(12):1596-603. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
DTHybrid score 0.6253

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.5363
6013 Cytochrome P450 2E1 CYP2E1 0.2737
6024 Cytochrome P450 1A1 CYP1A1 0.226
587 Serum albumin ALB 0.2011
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1939
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.1655
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1372
20 Prostaglandin G/H synthase 1 PTGS1 0.1349
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1238
492 Histamine H1 receptor HRH1 0.1182
6145 Solute carrier family 22 member 1 SLC22A1 0.1116
3923 Cholinesterase BCHE 0.105
824 Sodium-dependent serotonin transporter SLC6A4 0.1048
862 Multidrug resistance-associated protein 1 ABCC1 0.1033
6144 Solute carrier family 22 member 2 SLC22A2 0.1029
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1003
1729 Solute carrier family 22 member 6 SLC22A6 0.097
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0957
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0914
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0875
713 Sodium-dependent dopamine transporter SLC6A3 0.0823
833 Organic cation/carnitine transporter 1 SLC22A4 0.0815
3811 Cytochrome P450 19A1 CYP19A1 0.0798
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0781
465 Calmodulin CALM1 0.0775
1898 Cytochrome P450 1B1 CYP1B1 0.0773
4604 Liver carboxylesterase 1 CES1 0.0743
831 D(2) dopamine receptor DRD2 0.0734
502 5-hydroxytryptamine 2A receptor HTR2A 0.0727
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0711
556 Alpha-1A adrenergic receptor ADRA1A 0.0699
847 Mu-type opioid receptor OPRM1 0.065
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.065
341 5-hydroxytryptamine 3 receptor HTR3A 0.0645
290 Prostaglandin G/H synthase 2 PTGS2 0.0635
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0634
6147 Solute carrier family 22 member 3 SLC22A3 0.0632
6142 Solute carrier family 22 member 8 SLC22A8 0.062
776 Bile salt export pump ABCB11 0.0616
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0613
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0605
51 Muscarinic acetylcholine receptor M3 CHRM3 0.06
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0593
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0575
766 Beta-2 adrenergic receptor ADRB2 0.0569
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0566
320 5-hydroxytryptamine 1A receptor HTR1A 0.0561
318 Alpha-2A adrenergic receptor ADRA2A 0.0556
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0522
467 Delta-type opioid receptor OPRD1 0.0508
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0504
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0504
6031 Cytochrome P450 3A43 CYP3A43 0.0501
2178 Metabotropic glutamate receptor 5 GRM5 0.0496
871 Glucocorticoid receptor NR3C1 0.0494
468 Cytochrome P450 4A11 CYP4A11 0.0491
817 DNA topoisomerase 2-alpha TOP2A 0.0489
3941 Amine oxidase [flavin-containing] A MAOA 0.0486
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0477
136 Estrogen receptor ESR1 0.0477
590 5-hydroxytryptamine 2C receptor HTR2C 0.0476
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0476
6143 Solute carrier family 22 member 7 SLC22A7 0.047
193 Beta-1 adrenergic receptor ADRB1 0.0462
696 Kappa-type opioid receptor OPRK1 0.0457
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0456
23 D(1A) dopamine receptor DRD1 0.0452
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0443
477 DNA topoisomerase 4 subunit A parC 0.0434
886 DNA topoisomerase 4 subunit A parC 0.0434
6226 DNA topoisomerase 4 subunit A parC 0.0434
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0433
632 Alpha-1B adrenergic receptor ADRA1B 0.0429
2164 Multidrug resistance-associated protein 4 ABCC4 0.0428
404 DNA gyrase subunit A gyrA 0.0427
6224 DNA gyrase subunit A gyrA 0.0427
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0423
731 HIV-1 protease HIV-1 protease 0.0418
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0414
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0412
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0412
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0406
3939 Amine oxidase [flavin-containing] B MAOB 0.0399
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0395
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0392
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0389
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0387
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0386
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0377
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0374
260 Cytochrome P450 51 ERG11 0.036
761 Cytochrome P450 51 ERG11 0.036
3163 Cytochrome P450 51 cyp51 0.036
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.036
638 D(3) dopamine receptor DRD3 0.0359
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0352
1024 Solute carrier family 22 member 11 SLC22A11 0.0333
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0331
629 Alpha-2B adrenergic receptor ADRA2B 0.0325
885 5-hydroxytryptamine 1B receptor HTR1B 0.0325
6182 Cytochrome P450 2J2 CYP2J2 0.0314
5300 Antigen peptide transporter 1 TAP1 0.0304
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0298
789 Alpha-1D adrenergic receptor ADRA1D 0.0298
380 Cytochrome P450 17A1 CYP17A1 0.0295
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0287
378 Alpha-2C adrenergic receptor ADRA2C 0.0286
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0285
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0284
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0281
6148 Multidrug resistance-associated protein 7 ABCC10 0.0275
725 5-hydroxytryptamine 1D receptor HTR1D 0.0274
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0274
6220 Aryl hydrocarbon receptor AHR 0.0271
122 P2Y purinoceptor 12 P2RY12 0.0268
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0267
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0267
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0265
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0265
737 Mineralocorticoid receptor NR3C2 0.0259
614 Progesterone receptor PGR 0.0259
36 Insulin receptor INSR 0.0258
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0256
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0256
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0247
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0246
6137 Multidrug resistance-associated protein 6 ABCC6 0.0246
6014 Cytochrome P450 2A13 CYP2A13 0.0241
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0241
811 Translocator protein TSPO 0.0235
891 Dihydropteroate synthase folP 0.0234
5359 Dihydropteroate synthase folP 0.0234
7175 Dihydropteroate synthase sulI 0.0234
504 Mast/stem cell growth factor receptor KIT 0.0234
6102 Arylamine N-acetyltransferase 2 NAT2 0.023
432 D(4) dopamine receptor DRD4 0.0227
738 Monocarboxylate transporter 1 SLC16A1 0.0224
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0223
6136 Multidrug resistance-associated protein 5 ABCC5 0.0223
2782 Complement C1s subcomponent C1S 0.0221
474 Acetylcholinesterase ACHE 0.0216
1757 Myeloperoxidase MPO 0.0215
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0214
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0213
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0213
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0212
5787 Angiopoietin-1 receptor TEK 0.0212
146 Androgen receptor AR 0.0211
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.021
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.021
6020 Aldehyde oxidase AOX1 0.021
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0206
172 Potassium channel subfamily K member 1 KCNK1 0.0204
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0204
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0203
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0203
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0203
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0203
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0203
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0203
3817 Complement C1q subcomponent subunit C C1QC 0.0202
3816 Complement C1q subcomponent subunit B C1QB 0.0202
3815 Complement C1q subcomponent subunit A C1QA 0.0202
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0201
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0201
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.02
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.02
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.02
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.02
3814 Complement C1r subcomponent C1R 0.02
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0199
4120 NADPH--cytochrome P450 reductase POR 0.0199
232 Corticosteroid-binding globulin SERPINA6 0.0198
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0198
756 Sex hormone-binding globulin SHBG 0.0197
124 Histamine H2 receptor HRH2 0.0197
131 Synaptic vesicular amine transporter SLC18A2 0.0195
869 Estrogen receptor beta ESR2 0.0194
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0193
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0193
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0191
94 5-hydroxytryptamine 4 receptor HTR4 0.0191
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0189
436 5-hydroxytryptamine 2B receptor HTR2B 0.0188
159 Penicillin-binding protein 2B penA 0.0187
6121 Penicillin-binding protein 2B penA 0.0187
921 Glutamate receptor 2 GRIA2 0.0187
6141 Sodium/bile acid cotransporter SLC10A1 0.0186
716 5-hydroxytryptamine 7 receptor HTR7 0.0186
70 Type-1 angiotensin II receptor AGTR1 0.0185
818 50S ribosomal protein L10 rplJ 0.0184
4148 Serine/threonine-protein kinase mTOR MTOR 0.0183
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0182
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.018
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0179
183 Vascular endothelial growth factor A VEGFA 0.0179
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0178
407 Vascular endothelial growth factor receptor 2 KDR 0.0176
1010 Cytochrome P450 51A1 CYP51A1 0.0175
295 Carbonic anhydrase 1 CA1 0.0173
26 Vascular endothelial growth factor receptor 3 FLT4 0.0173
3950 Cell division protein kinase 9 CDK9 0.0171
3968 Cell division protein kinase 8 CDK8 0.0171
228 Beta platelet-derived growth factor receptor PDGFRB 0.0169
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0169
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0169
29 Tubulin beta-1 chain TUBB1 0.0167
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0167
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0167
32 Vascular endothelial growth factor receptor 1 FLT1 0.0165
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0164
777 Tumor necrosis factor TNF 0.0164
705 Glutamate receptor 1 GRIA1 0.0163
4237 50S ribosomal protein L22 rplV 0.016
1656 CYP2B protein CYP2B 0.0158
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0155
4238 50S ribosomal protein L4 rplD 0.0153
5578 50S ribosomal protein L4 rplD 0.0153
6173 50S ribosomal protein L4 rplD 0.0153
6219 50S ribosomal protein L4 rplD 0.0153
952 Dipeptidyl peptidase 4 DPP4 0.0153
427 Substance-P receptor TACR1 0.0152
6174 50S ribosomal protein L32 rpmF 0.0152
161 Tubulin beta chain TUBB 0.0152
312 Tubulin beta chain TUB2 0.0152
3959 Cell division protein kinase 4 CDK4 0.015
482 Glycine receptor subunit alpha-1 GLRA1 0.0149
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0149
3482 Cell division protein kinase 7 CDK7 0.0148
1192 Sulfotransferase 1A1 SULT1A1 0.0146
33 Cystine/glutamate transporter SLC7A11 0.0146
163 D(1B) dopamine receptor DRD5 0.0146
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0145
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0144
3947 Xanthine dehydrogenase/oxidase XDH 0.0142
275 Arachidonate 5-lipoxygenase ALOX5 0.0141
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0141
1636 Trace amine-associated receptor 1 TAAR1 0.014
592 Carbonic anhydrase 4 CA4 0.0139
84 Nuclear receptor 0B1 NR0B1 0.0139
3955 Cell division protein kinase 6 CDK6 0.0138
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0138
1178 Adenosine A2a receptor ADORA2A 0.0138
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0138
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0136
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0136
174 Sigma 1-type opioid receptor SIGMAR1 0.0135
16 Adenosine A1 receptor ADORA1 0.0134
6135 Sodium channel subunit beta-4 SCN4B 0.0131
6134 Sodium channel subunit beta-3 SCN3B 0.0131
6132 Sodium channel subunit beta-1 SCN1B 0.0131
6133 Sodium channel subunit beta-2 SCN2B 0.0131
6127 Carbonic anhydrase-related protein CA8 0.0131
6128 Carbonic anhydrase-related protein 10 CA10 0.0131
6129 Carbonic anhydrase-related protein 11 CA11 0.0131
85 Growth hormone receptor GHR 0.0131
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0131
6126 Carbonic anhydrase 7 CA7 0.013
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.013
373 Transthyretin TTR 0.0129
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0128
88 Retinoic acid receptor RXR-beta RXRB 0.0127
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0127
357 Carbonic anhydrase 2 CA2 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0126
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0125
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0124
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0124
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0124
1256 5-hydroxytryptamine 6 receptor HTR6 0.0124
6432 Transporter snf 0.0123
633 Penicillin-binding proteins 1A/1B pbpA 0.0123
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0123
537 ATP synthase delta chain, mitochondrial ATP5D 0.0122
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0122
4203 Histamine N-methyltransferase HNMT 0.0122
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.012
1742 D-HSCDK2 CDK2deltaT 0.0119
1771 Cell division control protein 2 homolog CDK1 0.0119
3321 Cell division control protein 2 homolog CRK2 0.0119
365 Dihydrofolate reductase DHFR 0.0118
2381 Dihydrofolate reductase DFR1 0.0118
2833 Dihydrofolate reductase Not Available 0.0118
2931 Dihydrofolate reductase folA 0.0118
3544 Dihydrofolate reductase folA 0.0118
3682 Dihydrofolate reductase folA 0.0118
6642 Dihydrofolate reductase folA 0.0118
6756 Dihydrofolate reductase dfrA 0.0118
528 5-hydroxytryptamine 1E receptor HTR1E 0.0118
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0117
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0117
6130 Carbonic anhydrase 13 CA13 0.0117
780 Retinoic acid receptor RXR-gamma RXRG 0.0116
1058 Cell division protein kinase 5 CDK5 0.0116
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0114
6131 Carbonic anhydrase 14 CA14 0.0114
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0113
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0113
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0111
3932 Glutathione S-transferase A2 GSTA2 0.0111
273 Apoptosis regulator Bcl-2 BCL2 0.011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0109
208 DNA-directed RNA polymerase beta' chain rpoC 0.0109
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0109
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0109
6122 Carbonic anhydrase 3 CA3 0.0109
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0108
3810 Catechol O-methyltransferase COMT 0.0107
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0107
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0106
6085 Fatty acid-binding protein, intestinal FABP2 0.0105
1050 Bile salt sulfotransferase SULT2A1 0.0105
165 FL cytokine receptor FLT3 0.0103
3808 Dihydropteroate synthase 2 folP2 0.0103
3601 Dihydropteroate synthase 1 folP1 0.0103
3807 Dihydropteroate synthase 1 folP1 0.0103
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0103
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
162 Retinoic acid receptor gamma-1 RARG 0.0101
719 Retinoic acid receptor responder protein 1 RARRES1 0.01
770 Retinoic acid-induced protein 3 GPRC5A 0.01
1517 Beta-3 adrenergic receptor ADRB3 0.01
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.01
4122 Histone deacetylase 2 HDAC2 0.01
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.01
768 FK506-binding protein 1A FKBP1A 0.01
469 Annexin A1 ANXA1 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0099
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0098
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0098
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0096
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0096
518 Peroxidase/catalase T katG 0.0095
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0094
239 Coagulation factor X F10 0.0093
319 Opioid receptor, sigma 1 OPRS1 0.0092
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0091
24 Thymidylate synthase TMP1 0.0091
359 Thymidylate synthase TYMS 0.0091
2626 Thymidylate synthase thyA 0.0091
2729 Thymidylate synthase thyA 0.0091
5352 Thymidylate synthase THYA 0.0091
1852 Microtubule-associated protein 2 MAP2 0.0091
4205 Carbonic anhydrase 9 CA9 0.0091
3007 Carbonic anhydrase 12 CA12 0.0091
976 Platelet glycoprotein IX GP9 0.0091
1039 Histone deacetylase 9 HDAC9 0.009
814 Ryanodine receptor 1 RYR1 0.009
571 Melatonin receptor type 1A MTNR1A 0.009
362 Melatonin receptor type 1B MTNR1B 0.009
2539 Tubulin alpha-1 chain TUBA4A 0.009
1353 DNA topoisomerase 1 TOP1 0.0089
3552 DNA topoisomerase 1 topA 0.0089
7 Nitric oxide synthase, inducible NOS2 0.0089
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0089
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0089
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
284 DNA-directed RNA polymerase beta chain rpoB 0.0088
5773 DNA-directed RNA polymerase beta chain rpoB 0.0088
751 Potassium channel subfamily K member 6 KCNK6 0.0088
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0088
569 Retinal dehydrogenase 2 ALDH1A2 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0087
511 5-hydroxytryptamine 1F receptor HTR1F 0.0087
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0087
6138 Multidrug resistance protein 3 ABCB4 0.0086
1618 High affinity nerve growth factor receptor NTRK1 0.0085
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0085
68 Cannabinoid receptor 1 CNR1 0.0085
563 Thyroid peroxidase TPO 0.0084
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0084
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0083
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
611 Retinal dehydrogenase 1 ALDH1A1 0.0082
1629 Transcription factor AP-1 JUN 0.0082
54 Prothrombin F2 0.0082
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
175 Thiamin pyrophosphokinase 1 TPK1 0.008
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0079
645 Penicillin-binding protein 1A mrcA 0.0079
5805 Penicillin-binding protein 1A ponA 0.0079
6185 Penicillin-binding protein 1A mrcA 0.0079
6799 Penicillin-binding protein 1A pbpA 0.0079
3809 Estrogen-related receptor gamma ESRRG 0.0079
823 Fibroblast growth factor receptor 2 FGFR2 0.0079
173 Toll-like receptor 7 TLR7 0.0079
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0079
153 Dopamine beta-hydroxylase DBH 0.0078
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0078
164 Histamine H4 receptor HRH4 0.0078
1360 Sphingomyelin phosphodiesterase SMPD1 0.0078
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
2230 Catalase CAT 0.0078
3249 Catalase katA 0.0078
3625 Catalase katA 0.0078
4539 Catalase katA 0.0078
4941 Catalase katB 0.0078
1152 Glycogen phosphorylase, muscle form PYGM 0.0077
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
2240 Cell division protein kinase 2 CDK2 0.0076
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0076
2449 Tubulin alpha-3 chain TUBA1A 0.0076
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0076
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0075
6044 Serum paraoxonase/lactonase 3 PON3 0.0075
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0075
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0075
1541 Metalloproteinase mmp20 0.0074
1275 Estrogen sulfotransferase SULT1E1 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
251 Alcohol dehydrogenase 1A ADH1A 0.0073
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0072
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.0071
1630 Integrin beta-2 ITGB2 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
3937 Fatty-acid amide hydrolase FAAH 0.007
49 Endothelin B receptor EDNRB 0.0069
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0069
444 Alcohol dehydrogenase 1B ADH1B 0.0069
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0068
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0068
3086 Plasmepsin-2 Not Available 0.0068
1196 Complement decay-accelerating factor CD55 0.0067
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0067
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0067
3426 Glutamine synthetase glnA 0.0066
3987 Glutamine synthetase GLUL 0.0066
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0066
3856 Fibroblast growth factor receptor 3 FGFR3 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
4311 tRNA TRDMT1 0.0065
4325 tRNA trmD 0.0065
4328 tRNA trmD 0.0065
5934 Cytochrome P450 26A1 CYP26A1 0.0065
856 Vitamin D3 receptor VDR 0.0064
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
558 Solute carrier family 12 member 1 SLC12A1 0.0063
904 Glutathione S-transferase P GSTP1 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
1648 Elastin ELN 0.0063
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
133 Dihydropterate synthase sulI 0.0063
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
4773 Deoxycytidine kinase DCK 0.0062
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0061
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0061
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0061
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0061
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
828 Phenylalanine-4-hydroxylase PAH 0.0059
3109 Phenylalanine-4-hydroxylase phhA 0.0059
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
1483 Membrane copper amine oxidase AOC3 0.0059
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0059
106 Cannabinoid receptor 2 CNR2 0.0058
517 Alcohol dehydrogenase 1C ADH1C 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
2808 Chloramphenicol acetyltransferase 3 cat3 0.0058
5880 Thrombopoietin receptor MPL 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
4103 Proteasome subunit beta type 2 PSMB2 0.0058
4102 Proteasome subunit beta type 5 PSMB5 0.0058
4101 Proteasome subunit beta type 1 PSMB1 0.0058
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0057
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0057
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0057
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0057
788 Creatine kinase M-type CKM 0.0057
1341 Histamine H3 receptor HRH3 0.0057
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0057
291 Nitric-oxide synthase, endothelial NOS3 0.0056
581 Cytochrome P450 2R1 CYP2R1 0.0056
6506 Stathmin-4 STMN4 0.0055
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
6149 Solute carrier family 22 member 10 SLC22A10 0.0054
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0053
2417 Chloramphenicol acetyltransferase cat 0.0053
3278 Chloramphenicol acetyltransferase cat 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
2810 Dr hemagglutinin structural subunit draA 0.0052
2981 Phospholipase A2, membrane associated PLA2G2A 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
6146 High affinity copper uptake protein 1 SLC31A1 0.0052
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0052
712 Tubulin alpha chain TUB1 0.0052
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6048 Troponin C, skeletal muscle TNNC2 0.005
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0049
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
6043 Putative G-protein coupled receptor 44 GPR44 0.0048
634 Squalene monooxygenase SQLE 0.0047
7196 Squalene monooxygenase ERG1 0.0047
4192 DNA topoisomerase 2-beta TOP2B 0.0047
3957 Adenosine deaminase ADA 0.0047
936 Ephrin type-A receptor 2 EPHA2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
3917 Methylenetetrahydrofolate reductase MTHFR 0.0046
4217 Telomerase reverse transcriptase TERT 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6824 Tyrosine-protein kinase Lyn LYN 0.0045
2298 Cytochrome P450-cam camC 0.0045
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0044
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0044
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0044
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0044
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0044
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0044
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0044
6168 Solute carrier family 22 member 16 SLC22A16 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0044
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0044
908 Glutathione S-transferase theta-1 GSTT1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0044
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0044
572 Integrin alpha-L ITGAL 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0043
1992 Vitamin D-binding protein GC 0.0043
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
267 Plasminogen activator inhibitor 1 SERPINE1 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
3913 Glutamic acid decarboxylase GAD65 0.0042
2300 Lysozyme E 0.0042
3633 Lysozyme R 0.0042
5597 Lysozyme 17 0.0042
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0042
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
229 Retinoic acid receptor beta RARB 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1864 RET proto-oncogene RET 0.0041
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.004
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.004
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.004
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
500 Monocarboxylate transporter 4 SLC16A3 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0039
4225 Uridine phosphorylase 1 UPP1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6221 Steroid hormone receptor ERR1 ESRRA 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
2207 Rhodopsin RHO 0.0036
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0036
5126 Arginase rocF 0.0036
6151 Monocarboxylate transporter 10 SLC16A10 0.0036
2216 Fibroblast growth factor receptor 4 FGFR4 0.0035
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0035
2320 Thymidine kinase, cytosolic TK1 0.0035
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0035
3904 Alanine aminotransferase 2 GPT2 0.0035
735 Alanine aminotransferase 1 GPT 0.0035
6218 Pannexin-1 PANX1 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0035
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0035
1268 Neuropeptide S receptor NPSR1 0.0035
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0033
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0033
499 Arginine decarboxylase ADC 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
489 Monocarboxylate transporter 2 SLC16A7 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6073 Potassium channel subfamily K member 9 KCNK9 0.0032
6072 Potassium channel subfamily K member 3 KCNK3 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1374 Natriuretic peptides B NPPB 0.0031
1827 Gap junction alpha-1 protein GJA1 0.0031
1908 Vascular cell adhesion protein 1 VCAM1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
5798 Mitogen-activated protein kinase 11 MAPK11 0.0031
577 Argininosuccinate lyase ASL 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
740 Argininosuccinate synthase ASS1 0.003
865 Argininosuccinate synthase ASS1 0.003
2680 Argininosuccinate synthase argG 0.003
3194 Argininosuccinate synthase argG 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
268 Adenosine A2b receptor ADORA2B 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0028
1063 Signal transducer and activator of transcription 5B STAT5B 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
400 Coagulation factor IX F9 0.0027
5461 Coagulation factor IX F9 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
820 Glycine receptor subunit alpha-2 GLRA2 0.0027
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0026
6859 Protein S100-A4 S100A4 0.0025
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0025
604 Vitamin K-dependent protein Z PROZ 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
896 Glutathione S-transferase Mu 1 GSTM1 0.0025
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
1245 Vitamin K-dependent protein S PROS1 0.0023
422 Vitamin K-dependent protein C PROC 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
6163 Copper-transporting ATPase 2 ATP7B 0.0021
6165 Copper-transporting ATPase 1 ATP7A 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
448 Vitamin K-dependent gamma-carboxylase GGCX 0.002
6459 Glycodelin PAEP 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
3221 Cytochrome c4 cc4 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
4948 Cytochrome c-553 Not Available 0.0019
4923 Cytochrome c3 DvMF_2499 0.0019
4945 Cytochrome c3 Not Available 0.0019
4949 Cytochrome c3 DVU_3171 0.0019
4968 Cytochrome c3 cytc3 0.0019
4997 Cytochrome c3 SO_2727 0.0019
5219 Cytochrome c3 cyd 0.0019
4902 Nine-heme cytochrome c Ddes_2038 0.0019
3189 High-molecular-weight cytochrome c hmcA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
798 Osteocalcin BGLAP 0.0019
2021 Thrombomodulin THBD 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4954 Soluble cytochrome b558 Not Available 0.0018
4925 Cytochrome c-type protein SHP shp 0.0018
4934 Cytochrome c-551 nirM 0.0018
5218 Cytochrome c-551 nirM 0.0018
4915 Cytochrome c-550 psbV 0.0018
4959 Cytochrome c-550 psbV 0.0018
5216 Cytochrome c-550 psbV 0.0018
4905 Cytochrome c2 Not Available 0.0018
4939 Cytochrome c2 cycA 0.0018
4964 Cytochrome c2 cycA 0.0018
4979 Cytochrome c2 cycA 0.0018
6673 Cytochrome c2 cycA 0.0018
4947 Bacterial hemoglobin vhb 0.0018
4975 Cytochrome c-556 RPA3973 0.0018
4916 Cyanoglobin glbN 0.0018
4943 Cytochrome c6 petJ 0.0018
4998 Hemoglobin-like protein yjbI yjbI 0.0018
4984 Neuroglobin NGB 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
4936 Cytochrome c2 iso-2 Not Available 0.0018
4994 Hemoglobin-like protein HbO glbO 0.0018
4907 Cytochrome c-L moxG 0.0018
6865 Cytochrome c-L moxG 0.0018
4909 CooA protein cooA 0.0018
644 Heme oxygenase 2 HMOX2 0.0018
4982 Heme oxygenase 2 pbsA2 0.0018
4942 Diheme cytochrome c napB napB 0.0018
4910 Cytoglobin CYGB 0.0018
4981 Iron-starvation protein PigA pigA 0.0018
4935 Cytochrome c-554 cycA1 0.0018
5000 HemO hemO 0.0018
4961 Hemophore HasA hasA 0.0018
4971 Nonaheme cytochrome c hmcA 0.0018
4904 Cytochrome c family protein GSU1996 0.0018
76 Nitric-oxide synthase, brain NOS1 0.0018
4976 Apocytochrome f petA 0.0018
6407 Apocytochrome f petA 0.0018
4989 Cytochrome c551 peroxidase ccp 0.0018
5222 Cytochrome c551 peroxidase ccpA 0.0018
4999 Cytochrome P450 165B3 CYP165B3 0.0018
4764 Cytochrome P450 165C4 CYP165C4 0.0018
4960 Putative cytochrome P450-family protein SCO7417 0.0018
4931 Cytochrome P450 167A1 CYP167A1 0.0018
4926 Heme-based aerotactic transducer hemAT hemAT 0.0018
4937 Cytochrome oxidase subunit II rcoxA 0.0018
4903 Methyl-accepting chemotaxis protein Tar4 0.0018
4993 Hydroxylamine oxidoreductase hao1 0.0018
4972 P450cin cinA 0.0018
4922 Cytochrome c, putative SO_4144 0.0018
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0018
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0018
3093 Catalase HPII katE 0.0018
4952 Catalase/peroxidase katA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
369 Coagulation factor VII F7 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0017
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0017
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
4386 Hemoglobin-like protein HbN glbN 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
3830 Calreticulin CALR 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6677 Myelin P2 protein PMP2 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
6036 Eosinophil peroxidase EPX 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
4920 Peroxidase/catalase katG 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
2119 Cytochrome b5 CYB5A 0.0013
4990 PpcA ppcA 0.0013
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0013
3375 Acidic cytochrome c3 Not Available 0.0013
4988 Sulfite oxidase, mitochondrial SUOX 0.0013
4385 Cytochrome c' Not Available 0.0013
4967 Cytochrome c' cycA 0.0013
5038 Cytochrome c' Not Available 0.0013
5223 Cytochrome c' cycP 0.0013
2915 Sensor protein fixL fixL 0.0013
4944 Sensor protein fixL fixL 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
3570 Cytochrome P450 152A1 cypC 0.0013
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
4813 Heme oxygenase hmuO 0.0013
5769 Heme oxygenase Not Available 0.0013
4289 Cytochrome P450 TT_P0059 0.0013
6262 Cytochrome P450 staP 0.0013
1507 Cytochrome c CYCS 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3670 Soluble cytochrome b562 precursor cybC 0.0011
3411 Cytochrome P450 121 cyp121 0.0011
3291 Cytochrome c-552 cycA 0.0011
4927 Cytochrome c-552 nrfA 0.0011
4938 Cytochrome c-552 cycA 0.0011
4953 Cytochrome c-552 nrfA 0.0011
5217 Cytochrome c-552 cycM 0.0011
2617 Nitric oxide synthase oxygenase nos 0.0011
2701 Nitric oxide synthase oxygenase nos 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.001
2972 6-deoxyerythronolide B hydroxylase eryF 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
358 Cystathionine beta-synthase CBS 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
693 Hemoglobin subunit beta HBB 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
1867 Major prion protein PRNP 0.0008
6268 Hydroxyacid oxidase 1 HAO1 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
810 Heme oxygenase 1 HMOX1 0.0008
3391 Heme oxygenase 1 pbsA1 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
822 Aldose reductase AKR1B1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
↑