DT-Web: DB00675

Identification

Name

Tamoxifen

Accession Number

DB00675 (APRD00123)

Type

small molecule

Description

One of the selective estrogen receptor modulators (SERM) with tissue-specific activities for the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

371.5146

Groups

approved

Monoisotopic Weight

371.224914555

Pharmacology

Indication

Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.

Mechanism of action

Tamoxifen is a nonsteroidal agent that binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes. The prolonged binding of tamoxifen to the nuclear chromatin of these results in reduced DNA polymerase activity, impaired thymidine utilization, blockade of estradiol uptake, and decreased estrogen response. It is likely that tamoxifen interacts with other coactivators or corepressors in the tissue and binds with different estrogen receptors, ER-alpha or ER-beta, producing both estrogenic and antiestrogenic effects.

Absorption

When a single oral dose of 20 mg is given, the average peak plasma concentration (Cmax) is 40 ng/mL which occurred approximately 5 hours after dosing (Tmax). The Cmax of N-desmethyl tamoxifen is 15 ng/mL. Steady-state concentrations for tamoxifen is achieved in 4 weeks, while steady-state concentrations for N-desmethyl tamoxifen is achieved in 8 weeks.

Protein binding

Not Available

Biotransformation

Hepatic. Tamoxifen is extensively metabolized after oral administration. N-Desmethyl-tamoxifen is the major metabolite found in plasma. N-Desmethyl-tamoxifen's activity is similar to tamoxifen. 4-hydroxy-tamoxifen and a side chain primary alcohol derivative of tamoxifen have been identified as minor metabolites in plasma. 4-Hydroxy-tamoxifen formation is catalyzed mainly by cytochrome P450 (CYP) 2D6, and also by CYP2C9 and 3A4. At high tamoxifen concentrations, CYP2B6 also catalyzes 4-hydroxylation of the parent drug. 4-Hydroxy-tamoxifen possesses 30- to 100-times greater affinity for the estrogen receptor and 30- to 100-times greater potency at inhibiting estrogen-dependent cell proliferation compared to tamoxifen. It is also metabolized by flavin monooxygenases FMO1 and FMO3 to form tamoxifen-N-oxide.

Route of elimination

65% of the dose was excreted from the body over 2 weeks in which fecal excretion was the primary route of elimination. Tamoxifen is excreted mainly as polar conjugates, with unchanged drug and unconjugated metabolites accounting for less than 30% of the total fecal radioactivity.

Toxicity

Signs observed at the highest doses following studies to determine LD₅₀ in animals were respiratory difficulties and convulsions.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acenocoumarol	Tamoxifen may increase the serum concentration of Acenocoumarol increasing the risk of bleeding. Concomitant therapy should be avoided.
Aminoglutethimide	Aminoglutethimide may increase Tamoxifen clearance decreasing its therapeutic effect. Consider alternate therapy or monitor for changes in Tamoxifen effects when Aminoglutethimide is initiated, discontinued or dose changed.
Amiodarone	Amiodarone may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Amprenavir	Amprenavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Atazanavir	Atazanavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Capecitabine	Capecitabine may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Capecitabine is initiated, discontinued or dose changed.
Chloroquine	Chloroquine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Chlorpromazine	Chlorpromazine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Cimetidine	Cimetidine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Cinacalcet	Cinacalcet may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Clarithromycin	Clarithromycin may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Clomipramine	Clomipramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Clozapine	Clozapine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Cocaine	Cocaine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Conivaptan	Conivaptan may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Darifenacin	Darifenacin may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Darunavir	Darunavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Delavirdine	Delavirdine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Desipramine	Desipramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Diphenhydramine	Diphenhydramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Duloxetine	Duloxetine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Floxuridine	Floxuridine may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Floxiridine is initiated, discontinued or dose changed.
Fluconazole	Fluconzole may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Fluconazole is initiated, discontinued or dose changed.
Fluorouracil	Fluorouracil may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Fluorouracil is initiated, discontinued or dose changed.
Fluoxetine	Fluoxetine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Flurbiprofen	Flurbiprofen may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Flurbiprofen is initiated, discontinued or dose changed.
Fosamprenavir	Fosmprenavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Gemfibrozil	Gemfibrozil may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Gemfibrozil is initiated, discontinued or dose changed.
Haloperidol	Haloperidol may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Ibuprofen	Ibuprofen may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Ibuprofen is initiated, discontinued or dose changed.
Imatinib	Imatinib may increase the serum concentration of Tamoxifen by decreasing its metabolism and clearance. Imatinib may also decrease the therapeutic effect of Tamoxifen by decreasing active metabolite production. Monitor for changes in the therapeutic/adverse effects of Tamoxifen if Imatinib is initiated, discontinued or dose changed.
Imipramine	Imipramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Indinavir	Indinavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Indomethacin	Indomethacin may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Indomethacin is initiated, discontinued or dose changed.
Isoniazid	Isoniazid may increase the serum concentration of Tamoxifen by decreasing its metabolism and clearance. Isoniazid may also decrease the therapeutic effect of Tamoxifen by decreasing active metabolite production. Monitor for changes in the therapeutic/adverse effects of Tamoxifen if Isoniazid is initiated, discontinued or dose changed.
Itraconazole	Itraconazole may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Ketoconazole	Ketoconazole may increase the serum concentration of Tamoxifen by decreasing its metabolism and clearance. Ketoconazole may also decrease the therapeutic effect of Tamoxifen by decreasing active metabolite production. Monitor for changes in the therapeutic/adverse effects of Tamoxifen if Ketoconazole is initiated, discontinued or dose changed.
Lidocaine	Lidocaine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Lopinavir	Lopinavir may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Lumefantrine	Lumefantrine, a moderate CYP2D6 inhibitor, may decrease the formation of highly potent tamoxifen metabolites. Concomitant therapy may decrease the effectiveness of tamoxifen. Consider alternate therapy.
Mefenamic acid	Mefenamic acid may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Mefenamic acid is initiated, discontinued or dose changed.
Methadone	Methadone may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Methimazole	Methimazole may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Miconazole	Miconazole may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Nefazodone	Nefazodone may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Nelfinavir	Nelfinavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Nicardipine	Nicardipine may increase the serum concentration of Tamoxifen by decreasing its metabolism and clearance. Nicardipine may also decrease the therapeutic effect of Tamoxifen by decreasing active metabolite production. Monitor for changes in the therapeutic/adverse effects of Tamoxifen if Nicardipine is initiated, discontinued or dose changed.
Nilotinib	Nilotinib may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Paroxetine	Paroxetine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Pergolide	Pergolide may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Pioglitazone	Pioglitazone may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Piroxicam	Piroxicam may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Piroxicam is initiated, discontinued or dose changed.
Posaconazole	Posaconazole may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Pyrimethamine	Pyrimethamine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Quinidine	Quinidine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Quinine	Quinine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Quinupristin	This combination presents an increased risk of toxicity
Ranolazine	Ranolazine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Rifabutin	The rifamycin decreases the effect of anti-estrogen
Rifampin	The rifamycin decreases the effect of anti-estrogen
Ritonavir	Ritonavir may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Rivaroxaban	Tamoxifen may increase serum concentrations of Rivaroxaban increasing the risk of bleeding. Concomitant therapy should be avoided.
Saquinavir	Saquinavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Sertraline	Sertraline may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Sitaxentan	Sitaxsentan may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Sitaxsentan is initiated, discontinued or dose changed.
Sulfadiazine	Sulfadiazine may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Sulfadiazine is initiated, discontinued or dose changed.
Sulfisoxazole	Sulfisoxazole may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Sulfisoxazole is initiated, discontinued or dose changed.
Telithromycin	Telithromycin may reduce clearance of Tamoxifen. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tamoxifen if Telithromycin is initiated, discontinued or dose changed.
Terbinafine	Terbinafine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Thioridazine	Thioridazine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Ticlopidine	Ticlopidine may decrease the therapeutic effect of tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tolbutamide	Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tamoxifen. Consider alternate therapy or monitor for changes in Tamoxifen therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Topotecan	The p-glycoprotein inhibitor, Tamoxifen, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tranylcypromine	The CYP2D6 inhibitor, Tranylcypromine, may decrease the efficacy of Tamoxifen by reducing active metabolite production. Consider alternate therapy.
Trazodone	Trazodone may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tretinoin	The moderate CYP2C8 inhibitor, Tamoxifen, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Tamoxifen is initiated, discontinued to dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of tamoxifen by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of tamoxifen if voriconazole is initiated, discontinued or dose changed.
Warfarin	Tamoxifen, a CYP2C9 inhibitor, may increase the serum concentration of warfarin by decreasing its metabolism. Concomitant therapy is contraindicated due to significant increase in bleed risk.

Food Interactions

Not Available

Estrogen receptor
Name	Estrogen receptor
Gene Name	ESR1
Pharmacological action	yes
Actions	antagonist,agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69. - Pubmed Fabian CJ, Kimler BF: Chemoprevention for high-risk women: tamoxifen and beyond. Breast J. 2001 Sep-Oct;7(5):311-20. - Pubmed Cyrus K, Wehenkel M, Choi EY, Lee H, Swanson H, Kim KB: Jostling for position: optimizing linker location in the design of estrogen receptor-targeting PROTACs. ChemMedChem. 2010 Jul 5;5(7):979-85. - Pubmed
DTHybrid score	0.9463
Estrogen receptor beta
Name	Estrogen receptor beta
Gene Name	ESR2
Pharmacological action	yes
Actions	antagonist,agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Chen B, Gajdos C, Dardes R, Kidwai N, Johnston SR, Dowsett M, Jordan VC: Potential of endogenous estrogen receptor beta to influence the selective ER modulator ERbeta complex. Int J Oncol. 2005 Aug;27(2):327-35. - Pubmed Horner-Glister E, Maleki-Dizaji M, Guerin CJ, Johnson SM, Styles J, White IN: Influence of oestradiol and tamoxifen on oestrogen receptors-alpha and -beta protein degradation and non-genomic signalling pathways in uterine and breast carcinoma cells. J Mol Endocrinol. 2005 Dec;35(3):421-32. - Pubmed Girault I, Bieche I, Lidereau R: Role of estrogen receptor alpha transcriptional coregulators in tamoxifen resistance in breast cancer. Maturitas. 2006 Jul 20;54(4):342-51. Epub 2006 Jul 5. - Pubmed Mc Ilroy M, Fleming FJ, Buggy Y, Hill AD, Young LS: Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence. Endocr Relat Cancer. 2006 Dec;13(4):1135-45. - Pubmed Gruvberger-Saal SK, Bendahl PO, Saal LH, Laakso M, Hegardt C, Eden P, Peterson C, Malmstrom P, Isola J, Borg A, Ferno M: Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res. 2007 Apr 1;13(7):1987-94. - Pubmed Sasson S: Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor. Pathol Biol (Paris). 1991 Jan;39(1):59-69. - Pubmed Hayes DF, Skaar TC, Rae JM, Henry NL, Nguyen AT, Stearns V, Li L, Philips S, Desta Z, Flockhart DA: Estrogen Receptor Genotypes, Menopausal Status, and the Effects of Tamoxifen on Lipid Levels: Revised and Updated Results. Clin Pharmacol Ther. 2010 Sep 8. - Pubmed
DTHybrid score	1.0029

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Higgins MJ, Stearns V: CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Kuderer NM, Peppercorn J: CYP2D6 testing in breast cancer: ready for prime time? Oncology (Williston Park). 2009 Dec;23(14):1223-32. - Pubmed Goetz MP: Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec;23(14):1233-4, 1236. - Pubmed Desta Z, Ward BA, Soukhova NV, Flockhart DA: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. Epub 2004 May 24. - Pubmed Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM: Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8911
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Desta Z, Ward BA, Soukhova NV, Flockhart DA: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. Epub 2004 May 24. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA: Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab Dispos. 2002 Aug;30(8):883-91. - Pubmed
DTHybrid score	1.4309
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7244
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.5561
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9414
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Desta Z, Ward BA, Soukhova NV, Flockhart DA: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. Epub 2004 May 24. - Pubmed Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM: Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8233
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Desta Z, Ward BA, Soukhova NV, Flockhart DA: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. Epub 2004 May 24. - Pubmed Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM: Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5937
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM: Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5333
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM: Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74. - Pubmed
DTHybrid score	0.8808
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM: Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2945
Dimethylaniline monooxygenase [N-oxide-forming] 1
Name	Dimethylaniline monooxygenase [N-oxide-forming] 1
Gene Name	FMO1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.2772
Dimethylaniline monooxygenase [N-oxide-forming] 3
Name	Dimethylaniline monooxygenase [N-oxide-forming] 3
Gene Name	FMO3
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.2187
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Walsky RL, Gaman EA, Obach RS: Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7133
Liver carboxylesterase 1
Name	Liver carboxylesterase 1
Gene Name	CES1
Actions	inhibitor
References	Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR: Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J Mol Biol. 2005 Sep 9;352(1):165-77. - Pubmed
DTHybrid score	0.5806
Cytochrome P450 19A1
Name	Cytochrome P450 19A1
Gene Name	CYP19A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4877
Cytochrome P450 2A6
Name	Cytochrome P450 2A6
Gene Name	CYP2A6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5277
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5759
UDP-glucuronosyltransferase 1-4
Name	UDP-glucuronosyltransferase 1-4
Gene Name	UGT1A4
Actions	substrate
References	Sun D, Sharma AK, Dellinger RW, Blevins-Primeau AS, Balliet RM, Chen G, Boyiri T, Amin S, Lazarus P: Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14. Epub 2007 Jul 30. - Pubmed
DTHybrid score	0.2009
Sulfotransferase 1A1
Name	Sulfotransferase 1A1
Gene Name	SULT1A1
Actions	substrate
References	Hertz DL, McLeod HL, Irvin WJ Jr: Tamoxifen and CYP2D6: a contradiction of data. Oncologist. 2012;17(5):620-30. doi: 10.1634/theoncologist.2011-0418. Epub 2012 Apr 24. - Pubmed
DTHybrid score	0.3348

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Riley J, Styles J, Verschoyle RD, Stanley LA, White IN, Gant TW: Association of tamoxifen biliary excretion rate with prior tamoxifen exposure and increased mdr1b expression. Biochem Pharmacol. 2000 Jul 15;60(2):233-9. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. - Pubmed Bekaii-Saab TS, Perloff MD, Weemhoff JL, Greenblatt DJ, von Moltke LL: Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A. Biopharm Drug Dispos. 2004 Oct;25(7):283-9. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
DTHybrid score	0.9655
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Janvilisri T, Venter H, Shahi S, Reuter G, Balakrishnan L, van Veen HW: Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51. Epub 2003 Mar 28. - Pubmed
DTHybrid score	0.462
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
DTHybrid score	0.2854
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Kiyotani K, Mushiroda T, Imamura CK, Hosono N, Tsunoda T, Kubo M, Tanigawara Y, Flockhart DA, Desta Z, Skaar TC, Aki F, Hirata K, Takatsuka Y, Okazaki M, Ohsumi S, Yamakawa T, Sasa M, Nakamura Y, Zembutsu H: Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J Clin Oncol. 2010 Mar 10;28(8):1287-93. doi: 10.1200/JCO.2009.25.7246. Epub 2010 Feb 1. - Pubmed
DTHybrid score	0.3762

Id	Partner name	Gene Name	Score
6228	Nuclear receptor coactivator 1	NCOA1	0.2597
6241	Nuclear receptor coactivator 2	NCOA2	0.2385
587	Serum albumin	ALB	0.2365
862	Multidrug resistance-associated protein 1	ABCC1	0.2217
20	Prostaglandin G/H synthase 1	PTGS1	0.2088
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1967
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1919
6106	Cytochrome P450 2C18	CYP2C18	0.1514
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1445
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1431
1729	Solute carrier family 22 member 6	SLC22A6	0.1379
6145	Solute carrier family 22 member 1	SLC22A1	0.1362
492	Histamine H1 receptor	HRH1	0.1318
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.1205
6144	Solute carrier family 22 member 2	SLC22A2	0.1205
260	Cytochrome P450 51	ERG11	0.1141
761	Cytochrome P450 51	ERG11	0.1141
3163	Cytochrome P450 51	cyp51	0.1141
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.1129
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1112
614	Progesterone receptor	PGR	0.1104
146	Androgen receptor	AR	0.1102
6142	Solute carrier family 22 member 8	SLC22A8	0.1085
824	Sodium-dependent serotonin transporter	SLC6A4	0.1061
290	Prostaglandin G/H synthase 2	PTGS2	0.1046
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.1039
756	Sex hormone-binding globulin	SHBG	0.1037
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1037
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1015
831	D(2) dopamine receptor	DRD2	0.1012
556	Alpha-1A adrenergic receptor	ADRA1A	0.0978
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.096
2164	Multidrug resistance-associated protein 4	ABCC4	0.0946
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0937
118	Organic cation/carnitine transporter 2	SLC22A5	0.0904
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0902
6143	Solute carrier family 22 member 7	SLC22A7	0.087
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0864
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0852
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0843
6147	Solute carrier family 22 member 3	SLC22A3	0.0842
6141	Sodium/bile acid cotransporter	SLC10A1	0.0835
844	Epidermal growth factor receptor	EGFR	0.0817
871	Glucocorticoid receptor	NR3C1	0.0814
817	DNA topoisomerase 2-alpha	TOP2A	0.0812
468	Cytochrome P450 4A11	CYP4A11	0.0809
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0808
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0803
6148	Multidrug resistance-associated protein 7	ABCC10	0.0778
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.076
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.076
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0757
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0727
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0724
3941	Amine oxidase [flavin-containing] A	MAOA	0.0719
847	Mu-type opioid receptor	OPRM1	0.0716
318	Alpha-2A adrenergic receptor	ADRA2A	0.0708
3947	Xanthine dehydrogenase/oxidase	XDH	0.0695
766	Beta-2 adrenergic receptor	ADRB2	0.0683
6031	Cytochrome P450 3A43	CYP3A43	0.068
23	D(1A) dopamine receptor	DRD1	0.0642
465	Calmodulin	CALM1	0.0638
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0638
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0634
6102	Arylamine N-acetyltransferase 2	NAT2	0.0626
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0623
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0618
833	Organic cation/carnitine transporter 1	SLC22A4	0.0609
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0604
1024	Solute carrier family 22 member 11	SLC22A11	0.0599
632	Alpha-1B adrenergic receptor	ADRA1B	0.0596
713	Sodium-dependent dopamine transporter	SLC6A3	0.0587
1050	Bile salt sulfotransferase	SULT2A1	0.0574
731	HIV-1 protease	HIV-1 protease	0.0572
193	Beta-1 adrenergic receptor	ADRB1	0.0565
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0555
1275	Estrogen sulfotransferase	SULT1E1	0.0547
6137	Multidrug resistance-associated protein 6	ABCC6	0.0538
638	D(3) dopamine receptor	DRD3	0.0534
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0534
467	Delta-type opioid receptor	OPRD1	0.0532
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0531
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0527
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0526
6560	Nuclear receptor coactivator 5	NCOA5	0.0526
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0523
5787	Angiopoietin-1 receptor	TEK	0.0515
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0515
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0513
504	Mast/stem cell growth factor receptor	KIT	0.0499
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0491
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.049
696	Kappa-type opioid receptor	OPRK1	0.0488
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0486
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0486
183	Vascular endothelial growth factor A	VEGFA	0.0479
629	Alpha-2B adrenergic receptor	ADRA2B	0.0468
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0467
3923	Cholinesterase	BCHE	0.0465
3939	Amine oxidase [flavin-containing] B	MAOB	0.0459
1757	Myeloperoxidase	MPO	0.045
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0448
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0441
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0437
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0435
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0435
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0427
3437	Eosinophil lysophospholipase	CLC	0.0424
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0423
380	Cytochrome P450 17A1	CYP17A1	0.0423
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0417
1852	Microtubule-associated protein 2	MAP2	0.0415
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0413
4382	Sulfotransferase family cytosolic 1B member 1	SULT1B1	0.0411
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0409
3317	Holo-[acyl-carrier-protein] synthase	acpS	0.0406
4381	Holo-[acyl-carrier-protein] synthase	acpS	0.0406
4380	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1	NDST1	0.0406
122	P2Y purinoceptor 12	P2RY12	0.0404
6014	Cytochrome P450 2A13	CYP2A13	0.0403
378	Alpha-2C adrenergic receptor	ADRA2C	0.0402
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0399
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0399
70	Type-1 angiotensin II receptor	AGTR1	0.0396
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0396
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.039
4120	NADPH--cytochrome P450 reductase	POR	0.0387
124	Histamine H2 receptor	HRH2	0.0386
477	DNA topoisomerase 4 subunit A	parC	0.0386
886	DNA topoisomerase 4 subunit A	parC	0.0386
6226	DNA topoisomerase 4 subunit A	parC	0.0386
6182	Cytochrome P450 2J2	CYP2J2	0.0383
6220	Aryl hydrocarbon receptor	AHR	0.0381
432	D(4) dopamine receptor	DRD4	0.0381
404	DNA gyrase subunit A	gyrA	0.038
6224	DNA gyrase subunit A	gyrA	0.038
373	Transthyretin	TTR	0.0375
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0372
6136	Multidrug resistance-associated protein 5	ABCC5	0.0366
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0365
716	5-hydroxytryptamine 7 receptor	HTR7	0.0363
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0362
3809	Estrogen-related receptor gamma	ESRRG	0.0359
1010	Cytochrome P450 51A1	CYP51A1	0.0356
2390	Nonsecretory ribonuclease	RNASE2	0.0354
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0354
29	Tubulin beta-1 chain	TUBB1	0.0352
856	Vitamin D3 receptor	VDR	0.0349
6606	Platelet-activating factor acetylhydrolase IB subunit gamma	PAFAH1B3	0.0348
4175	Platelet-activating factor acetylhydrolase	PLA2G7	0.0348
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0344
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0343
777	Tumor necrosis factor	TNF	0.0337
789	Alpha-1D adrenergic receptor	ADRA1D	0.0332
4116	Dihydropteroate synthetase	Not Available	0.033
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0329
563	Thyroid peroxidase	TPO	0.0322
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0319
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0318
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0317
6020	Aldehyde oxidase	AOX1	0.0317
737	Mineralocorticoid receptor	NR3C2	0.0314
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0313
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0312
1178	Adenosine A2a receptor	ADORA2A	0.0311
161	Tubulin beta chain	TUBB	0.0302
312	Tubulin beta chain	TUB2	0.0302
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0294
232	Corticosteroid-binding globulin	SERPINA6	0.0293
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0292
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0291
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0291
407	Vascular endothelial growth factor receptor 2	KDR	0.0286
16	Adenosine A1 receptor	ADORA1	0.0285
1353	DNA topoisomerase 1	TOP1	0.0278
3552	DNA topoisomerase 1	topA	0.0278
26	Vascular endothelial growth factor receptor 3	FLT4	0.0278
273	Apoptosis regulator Bcl-2	BCL2	0.0277
891	Dihydropteroate synthase	folP	0.0276
5359	Dihydropteroate synthase	folP	0.0276
7175	Dihydropteroate synthase	sulI	0.0276
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0272
738	Monocarboxylate transporter 1	SLC16A1	0.0271
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.027
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0268
811	Translocator protein	TSPO	0.0267
32	Vascular endothelial growth factor receptor 1	FLT1	0.0266
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0263
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0263
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0261
36	Insulin receptor	INSR	0.0258
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0258
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0257
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0256
5923	Microtubule-associated protein tau	MAPT	0.0256
5924	Microtubule-associated protein 4	MAP4	0.0256
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0256
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0256
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0256
33	Cystine/glutamate transporter	SLC7A11	0.0255
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0254
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0252
3810	Catechol O-methyltransferase	COMT	0.0249
24	Thymidylate synthase	TMP1	0.0248
359	Thymidylate synthase	TYMS	0.0248
2626	Thymidylate synthase	thyA	0.0248
2729	Thymidylate synthase	thyA	0.0248
5352	Thymidylate synthase	THYA	0.0248
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0247
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0247
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0247
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0247
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0247
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0246
1656	CYP2B protein	CYP2B	0.0245
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0245
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0243
2808	Chloramphenicol acetyltransferase 3	cat3	0.0243
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0241
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0241
226	Gonadotropin-releasing hormone receptor	GNRHR	0.024
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0237
2107	Microtubule-associated protein 1A	MAP1A	0.0236
482	Glycine receptor subunit alpha-1	GLRA1	0.0233
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0233
94	5-hydroxytryptamine 4 receptor	HTR4	0.023
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.023
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0229
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0229
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0229
84	Nuclear receptor 0B1	NR0B1	0.0228
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0226
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0225
131	Synaptic vesicular amine transporter	SLC18A2	0.0224
1629	Transcription factor AP-1	JUN	0.0223
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.022
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.022
469	Annexin A1	ANXA1	0.0219
705	Glutamate receptor 1	GRIA1	0.0219
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0218
6044	Serum paraoxonase/lactonase 3	PON3	0.0216
992	Protein tyrosine kinase 2 beta	PTK2B	0.0216
571	Melatonin receptor type 1A	MTNR1A	0.0216
362	Melatonin receptor type 1B	MTNR1B	0.0216
275	Arachidonate 5-lipoxygenase	ALOX5	0.0214
2539	Tubulin alpha-1 chain	TUBA4A	0.0213
3601	Dihydropteroate synthase 1	folP1	0.0212
3807	Dihydropteroate synthase 1	folP1	0.0212
3808	Dihydropteroate synthase 2	folP2	0.0212
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0211
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0211
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0211
936	Ephrin type-A receptor 2	EPHA2	0.021
4203	Histamine N-methyltransferase	HNMT	0.021
908	Glutathione S-transferase theta-1	GSTT1	0.0209
49	Endothelin B receptor	EDNRB	0.0209
6146	High affinity copper uptake protein 1	SLC31A1	0.0209
5682	Ribonuclease pancreatic	RNASE1	0.0208
904	Glutathione S-transferase P	GSTP1	0.0207
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0207
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0206
6859	Protein S100-A4	S100A4	0.0206
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0205
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0205
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0204
683	Potassium transporter	GK0582	0.0203
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0203
244	Angiotensin-converting enzyme	ACE	0.0202
165	FL cytokine receptor	FLT3	0.0201
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0201
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0199
2449	Tubulin alpha-3 chain	TUBA1A	0.0198
442	Envelope glycoprotein	gp41	0.0198
4859	Envelope glycoprotein	env	0.0198
818	50S ribosomal protein L10	rplJ	0.0198
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0197
578	Endothelin-1 receptor	EDNRA	0.0197
6085	Fatty acid-binding protein, intestinal	FABP2	0.0196
484	Tyrosine-protein kinase ABL2	ABL2	0.0194
4228	Keratin, type II cytoskeletal 7	KRT7	0.0194
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0193
4122	Histone deacetylase 2	HDAC2	0.0192
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0192
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0191
5934	Cytochrome P450 26A1	CYP26A1	0.0189
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0189
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0188
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0188
7	Nitric oxide synthase, inducible	NOS2	0.0186
474	Acetylcholinesterase	ACHE	0.0186
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0184
267	Plasminogen activator inhibitor 1	SERPINE1	0.0183
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
3932	Glutathione S-transferase A2	GSTA2	0.0183
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0182
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0181
3270	Elongation factor G	fusA	0.0181
2178	Metabotropic glutamate receptor 5	GRM5	0.0181
921	Glutamate receptor 2	GRIA2	0.0181
163	D(1B) dopamine receptor	DRD5	0.018
4192	DNA topoisomerase 2-beta	TOP2B	0.018
613	Atrial natriuretic peptide receptor A	NPR1	0.0179
823	Fibroblast growth factor receptor 2	FGFR2	0.0179
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0177
148	Lutropin-choriogonadotropic hormone receptor	LHCGR	0.0175
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0174
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0172
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0171
952	Dipeptidyl peptidase 4	DPP4	0.0171
427	Substance-P receptor	TACR1	0.017
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.017
6221	Steroid hormone receptor ERR1	ESRRA	0.0168
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0167
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0166
3957	Adenosine deaminase	ADA	0.0164
54	Prothrombin	F2	0.0164
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0163
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0162
6163	Copper-transporting ATPase 2	ATP7B	0.0161
6165	Copper-transporting ATPase 1	ATP7A	0.0161
4237	50S ribosomal protein L22	rplV	0.016
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
117	Sterol O-acyltransferase 1	SOAT1	0.0158
164	Histamine H4 receptor	HRH4	0.0158
3639	Thymidine phosphorylase	deoA	0.0157
3936	Thymidine phosphorylase	TYMP	0.0157
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0157
887	DNA gyrase subunit B	gyrB	0.0156
4150	DNA gyrase subunit B	gyrB	0.0156
6225	DNA gyrase subunit B	gyrB	0.0156
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0156
1517	Beta-3 adrenergic receptor	ADRB3	0.0156
814	Ryanodine receptor 1	RYR1	0.0156
295	Carbonic anhydrase 1	CA1	0.0155
365	Dihydrofolate reductase	DHFR	0.0155
2381	Dihydrofolate reductase	DFR1	0.0155
2833	Dihydrofolate reductase	Not Available	0.0155
2931	Dihydrofolate reductase	folA	0.0155
3544	Dihydrofolate reductase	folA	0.0155
3682	Dihydrofolate reductase	folA	0.0155
6642	Dihydrofolate reductase	folA	0.0155
6756	Dihydrofolate reductase	dfrA	0.0155
174	Sigma 1-type opioid receptor	SIGMAR1	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0154
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0153
4238	50S ribosomal protein L4	rplD	0.0153
5578	50S ribosomal protein L4	rplD	0.0153
6173	50S ribosomal protein L4	rplD	0.0153
6219	50S ribosomal protein L4	rplD	0.0153
88	Retinoic acid receptor RXR-beta	RXRB	0.0153
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0151
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0151
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0151
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.015
4773	Deoxycytidine kinase	DCK	0.015
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0149
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0148
6167	Organic solute transporter subunit beta	OSTB	0.0148
6166	Organic solute transporter subunit alpha	OSTA	0.0148
68	Cannabinoid receptor 1	CNR1	0.0148
3830	Calreticulin	CALR	0.0147
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0146
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0146
780	Retinoic acid receptor RXR-gamma	RXRG	0.0145
2499	Tubulin beta-2C chain	TUBB2C	0.0144
896	Glutathione S-transferase Mu 1	GSTM1	0.0143
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0141
517	Alcohol dehydrogenase 1C	ADH1C	0.014
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.014
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0138
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0138
6035	Nuclear receptor ROR-beta	RORB	0.0137
6034	Hydroxyindole O-methyltransferase	ASMT	0.0137
6036	Eosinophil peroxidase	EPX	0.0136
251	Alcohol dehydrogenase 1A	ADH1A	0.0136
3611	Cytidine deaminase	cdd	0.0135
3707	Cytidine deaminase	cdd	0.0135
4211	Cytidine deaminase	CDA	0.0135
444	Alcohol dehydrogenase 1B	ADH1B	0.0132
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0132
239	Coagulation factor X	F10	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
6168	Solute carrier family 22 member 16	SLC22A16	0.0131
1714	Mitogen-activated protein kinase 3	MAPK3	0.013
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0129
3856	Fibroblast growth factor receptor 3	FGFR3	0.0129
790	DNA polymerase subunit alpha B	POLA2	0.0129
322	Vasopressin V2 receptor	AVPR2	0.0128
284	DNA-directed RNA polymerase beta chain	rpoB	0.0128
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0128
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0127
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0127
162	Retinoic acid receptor gamma-1	RARG	0.0126
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0126
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0126
2112	Toll-like receptor 9	TLR9	0.0126
1618	High affinity nerve growth factor receptor	NTRK1	0.0126
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0126
106	Cannabinoid receptor 2	CNR2	0.0125
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0125
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0125
592	Carbonic anhydrase 4	CA4	0.0125
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0124
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0124
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0123
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0123
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0123
634	Squalene monooxygenase	SQLE	0.0122
7196	Squalene monooxygenase	ERG1	0.0122
518	Peroxidase/catalase T	katG	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
461	Glycine receptor subunit alpha-3	GLRA3	0.0121
1569	G1/S-specific cyclin-D1	CCND1	0.0121
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0121
1141	Sialidase-1	NEU1	0.012
64	Neuraminidase	NA	0.012
641	Neuraminidase	NA	0.012
2676	Neuraminidase	NA	0.012
3026	Neuraminidase	NA	0.012
3519	Neuraminidase	NA	0.012
6007	Neuraminidase	NA	0.012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.012
511	5-hydroxytryptamine 1F receptor	HTR1F	0.012
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0118
765	Indoleamine 2,3-dioxygenase	IDO1	0.0118
687	Tyrosine-protein phosphatase non-receptor type 1	PTPN1	0.0118
1039	Histone deacetylase 9	HDAC9	0.0118
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0118
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0118
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0117
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0116
48	Pyridoxal kinase	PDXK	0.0116
1649	Small inducible cytokine A2	CCL2	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0115
6043	Putative G-protein coupled receptor 44	GPR44	0.0115
319	Opioid receptor, sigma 1	OPRS1	0.0114
2230	Catalase	CAT	0.0114
3249	Catalase	katA	0.0114
3625	Catalase	katA	0.0114
4539	Catalase	katA	0.0114
4941	Catalase	katB	0.0114
4311	tRNA	TRDMT1	0.0113
4325	tRNA	trmD	0.0113
4328	tRNA	trmD	0.0113
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
1650	Heme carrier protein 1	SLC46A1	0.0113
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0113
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
958	Insulin-like growth factor 1 receptor	IGF1R	0.0109
2443	Azurin	azu	0.0108
357	Carbonic anhydrase 2	CA2	0.0107
723	Cytosolic phospholipase A2	PLA2G4A	0.0106
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0106
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0105
6766	O-GlcNAcase BT_4395	BT_4395	0.0105
6138	Multidrug resistance protein 3	ABCB4	0.0105
3937	Fatty-acid amide hydrolase	FAAH	0.0105
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0104
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0104
976	Platelet glycoprotein IX	GP9	0.0104
6432	Transporter	snf	0.0103
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0103
5482	Sialidase-2	NEU2	0.0102
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0102
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0102
6174	50S ribosomal protein L32	rpmF	0.0102
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
1176	Mitogen-activated protein kinase 1	MAPK1	0.01
3587	Gastrotropin	FABP6	0.01
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
1630	Integrin beta-2	ITGB2	0.0099
751	Potassium channel subfamily K member 6	KCNK6	0.0099
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0099
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
5300	Antigen peptide transporter 1	TAP1	0.0096
153	Dopamine beta-hydroxylase	DBH	0.0095
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0095
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0094
6126	Carbonic anhydrase 7	CA7	0.0094
820	Glycine receptor subunit alpha-2	GLRA2	0.0094
381	Prolactin receptor	PRLR	0.0093
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0093
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0092
172	Potassium channel subfamily K member 1	KCNK1	0.0091
6211	Tubulin epsilon chain	TUBE1	0.0091
6210	Tubulin delta chain	TUBD1	0.0091
6212	Tubulin gamma-1 chain	TUBG1	0.0091
6149	Solute carrier family 22 member 10	SLC22A10	0.009
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0089
291	Nitric-oxide synthase, endothelial	NOS3	0.0089
2236	Casein kinase II subunit alpha	CSNK2A1	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
268	Adenosine A2b receptor	ADORA2B	0.0088
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0088
459	Retinoic acid receptor RXR-alpha	RXRA	0.0088
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0087
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0087
2216	Fibroblast growth factor receptor 4	FGFR4	0.0087
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0086
581	Cytochrome P450 2R1	CYP2R1	0.0085
6824	Tyrosine-protein kinase Lyn	LYN	0.0084
229	Retinoic acid receptor beta	RARB	0.0084
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0084
4103	Proteasome subunit beta type 2	PSMB2	0.0083
4102	Proteasome subunit beta type 5	PSMB5	0.0083
4101	Proteasome subunit beta type 1	PSMB1	0.0083
730	Retinoic acid receptor alpha	RARA	0.0083
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0082
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0082
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0082
569	Retinal dehydrogenase 2	ALDH1A2	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0081
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0081
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0081
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0081
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0081
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0081
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0081
1483	Membrane copper amine oxidase	AOC3	0.0081
5626	Nucleoside diphosphate kinase B	NME2	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.008
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.008
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.008
719	Retinoic acid receptor responder protein 1	RARRES1	0.008
770	Retinoic acid-induced protein 3	GPRC5A	0.008
1196	Complement decay-accelerating factor	CD55	0.008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0079
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0079
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0079
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0079
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0079
173	Toll-like receptor 7	TLR7	0.0079
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0078
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0077
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0076
611	Retinal dehydrogenase 1	ALDH1A1	0.0076
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0076
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0076
144	Hemoglobin subunit alpha	HBA1	0.0076
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0076
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
558	Solute carrier family 12 member 1	SLC12A1	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
1541	Metalloproteinase	mmp20	0.0074
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0073
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0072
5414	Fiber protein	L5	0.0071
5418	Fiber protein	L5	0.0071
1756	E-selectin	SELE	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
4217	Telomerase reverse transcriptase	TERT	0.007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.007
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
890	Niemann-Pick C1-like protein 1	NPC1L1	0.007
1992	Vitamin D-binding protein	GC	0.007
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0069
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0069
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0069
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0069
3086	Plasmepsin-2	Not Available	0.0068
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
1636	Trace amine-associated receptor 1	TAAR1	0.0067
3913	Glutamic acid decarboxylase	GAD65	0.0066
5294	Nucleoside diphosphate kinase A	NME1	0.0066
2391	Ferrochelatase	hemH	0.0066
6502	Ferrochelatase	DKFZp686P18130	0.0066
1591	Ferrochelatase, mitochondrial	FECH	0.0066
572	Integrin alpha-L	ITGAL	0.0065
76	Nitric-oxide synthase, brain	NOS1	0.0064
1820	Beta-nerve growth factor	NGF	0.0064
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
1648	Elastin	ELN	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
4210	Toll-like receptor 4	TLR4	0.0063
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0063
1760	Aminopeptidase N	ANPEP	0.0063
6843	Aminopeptidase N	pepN	0.0063
133	Dihydropterate synthase	sulI	0.0063
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0062
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
3629	Endo-N-acetylneuraminidase	Not Available	0.0062
5416	Coat protein VP1	Not Available	0.0061
1130	Lithostathine 1 alpha	REG1A	0.0061
2298	Cytochrome P450-cam	camC	0.0061
293	Gamma-glutamyl hydrolase	GGH	0.0061
1291	cAMP response element-binding protein	CREB1	0.0061
1374	Natriuretic peptides B	NPPB	0.0061
1827	Gap junction alpha-1 protein	GJA1	0.0061
1908	Vascular cell adhesion protein 1	VCAM1	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
1864	RET proto-oncogene	RET	0.006
4226	Uridine phosphorylase 2	UPP2	0.006
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0059
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0059
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0059
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0059
2232	Interleukin-5	IL5	0.0059
1593	Mucin-2	MUC2	0.0059
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0059
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0059
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0059
2599	Tyrosine-protein kinase HCK	HCK	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
400	Coagulation factor IX	F9	0.0057
5461	Coagulation factor IX	F9	0.0057
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0057
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0057
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0057
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0057
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0057
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0057
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0057
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0057
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0057
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0057
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0057
6559	Cytochrome c oxidase subunit 2	ctaC	0.0057
6669	Cytochrome c oxidase subunit 2	ctaC	0.0057
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0057
6558	Cytochrome c oxidase subunit 1	ctaD	0.0057
2324	Botulinum neurotoxin type B	botB	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
3547	Enterotoxin type B	entB	0.0057
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0057
2058	P-selectin	SELP	0.0056
551	Carnitine O-acetyltransferase	CRAT	0.0056
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
3904	Alanine aminotransferase 2	GPT2	0.0056
735	Alanine aminotransferase 1	GPT	0.0056
489	Monocarboxylate transporter 2	SLC16A7	0.0055
2320	Thymidine kinase, cytosolic	TK1	0.0055
4225	Uridine phosphorylase 1	UPP1	0.0055
6042	Prostaglandin reductase 2	PTGR2	0.0055
6506	Stathmin-4	STMN4	0.0055
65	Matrix metalloproteinase-9	Not Available	0.0054
6837	Serine/threonine-protein kinase 17B	STK17B	0.0054
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0054
390	Adenosine A3 receptor	ADORA3	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0052
604	Vitamin K-dependent protein Z	PROZ	0.0052
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0052
2540	Choloylglycine hydrolase	cbh	0.0052
1262	Corticotropin-lipotropin	POMC	0.0052
2207	Rhodopsin	RHO	0.0052
712	Tubulin alpha chain	TUB1	0.0052
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
3090	Chitosanase	csn	0.0052
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0052
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
413	Amidophosphoribosyltransferase	PPAT	0.0051
2515	Amidophosphoribosyltransferase	purF	0.0051
3714	Amidophosphoribosyltransferase	purF	0.0051
5798	Mitogen-activated protein kinase 11	MAPK11	0.0051
6500	Phospholipase A2	PLA2G1B	0.0051
6048	Troponin C, skeletal muscle	TNNC2	0.005
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0049
2570	Tetanus toxin	tetX	0.0049
6501	Fatty acid-binding protein, liver	FABP1	0.0049
1123	Eosinophil cationic protein	RNASE3	0.0049
3404	Exotoxin A	eta	0.0049
1313	Lactoylglutathione lyase	GLO1	0.0048
422	Vitamin K-dependent protein C	PROC	0.0048
1245	Vitamin K-dependent protein S	PROS1	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0047
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0047
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0047
714	Glutathione reductase, mitochondrial	GSR	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
1253	Interferon gamma	IFNG	0.0046
702	UMP-CMP kinase	CMPK1	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
718	Folate receptor gamma	FOLR3	0.0045
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0045
299	Folate receptor beta	FOLR2	0.0045
3814	Complement C1r subcomponent	C1R	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0044
1268	Neuropeptide S receptor	NPSR1	0.0044
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0044
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0043
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0043
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
2723	Cholera enterotoxin subunit B	ctxB	0.0042
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0041
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0041
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.004
6073	Potassium channel subfamily K member 9	KCNK9	0.004
6072	Potassium channel subfamily K member 3	KCNK3	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
798	Osteocalcin	BGLAP	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0039
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0039
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
85	Growth hormone receptor	GHR	0.0038
594	Thyroxine-binding globulin	SERPINA7	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
2782	Complement C1s subcomponent	C1S	0.0037
6218	Pannexin-1	PANX1	0.0036
760	Fibroblast growth factor 1	FGF1	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
6131	Carbonic anhydrase 14	CA14	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
340	Apoptotic protease-activating factor 1	APAF1	0.0035
369	Coagulation factor VII	F7	0.0035
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
758	Thyroid hormone receptor alpha	THRA	0.0034
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0034
3815	Complement C1q subcomponent subunit A	C1QA	0.0034
3816	Complement C1q subcomponent subunit B	C1QB	0.0034
3817	Complement C1q subcomponent subunit C	C1QC	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0034
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0034
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0034
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0034
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0034
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0034
6122	Carbonic anhydrase 3	CA3	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0032
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.003
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.003
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
292	Activin receptor type-1	ACVR1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
6459	Glycodelin	PAEP	0.0028
849	Activated CDC42 kinase 1	TNK2	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
1243	Cathepsin D	CTSD	0.0027
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
358	Cystathionine beta-synthase	CBS	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
2408	Tyrosine-protein kinase SYK	SYK	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
5818	Folate receptor alpha	FOLR1	0.0025
2021	Thrombomodulin	THBD	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
3007	Carbonic anhydrase 12	CA12	0.0025
4205	Carbonic anhydrase 9	CA9	0.0025
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0024
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0023
822	Aldose reductase	AKR1B1	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
6021	Adenosine kinase	ADK	0.0023
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0023
3221	Cytochrome c4	cc4	0.0023
707	72 kDa type IV collagenase	MMP2	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
997	Protein kinase C beta type	PRKCB	0.0021
298	Renin	REN	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
1970	Protein kinase C alpha type	PRKCA	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4878	Glycoprotein hormones alpha chain	CGA	0.002
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.002
1072	Granzyme B	GZMB	0.002
4877	Beta-mannanase	man	0.002
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.002
4850	Beta-2-glycoprotein 1	APOH	0.002
4856	CD209 antigen	CD209	0.002
4889	Ig epsilon chain C region	IGHE	0.002
4869	Major capsid protein	A430L	0.002
4852	Reticulon-4 receptor	RTN4R	0.002
4880	Membrane cofactor protein	CD46	0.002
757	Fusion glycoprotein F0	F	0.002
4875	Fusion glycoprotein F0	F	0.002
4721	Beta-1,4-mannanase	manA	0.002
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.002
1354	Beta-glucuronidase	GUSB	0.002
4189	Alpha-galactosidase A	GLA	0.002
4845	ADAM 33	ADAM33	0.002
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.002
3352	Structural polyprotein	Not Available	0.002
3628	Structural polyprotein	Not Available	0.002
4892	Structural polyprotein	Not Available	0.002
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.002
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
1792	Tissue-type plasminogen activator	PLAT	0.0017
6858	Inactive carboxylesterase 4	CES1P1	0.0017
793	T-cell surface antigen CD2	CD2	0.0017
4861	Interleukin-6 receptor alpha chain	IL6R	0.0017
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0017
3837	Cytokine receptor common beta chain	CSF2RB	0.0017
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
6151	Monocarboxylate transporter 10	SLC16A10	0.0017
4041	Microsomal glutathione S-transferase 2	MGST2	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
4890	Hemagglutinin	HA	0.0016
6566	Hemagglutinin	Not Available	0.0016
1379	Interleukin-12 subunit beta	IL12B	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
1184	Interferon beta	IFNB1	0.0015
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
6677	Myelin P2 protein	PMP2	0.0015
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0015
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1859	Prostatic acid phosphatase	ACPP	0.0014
3140	Hemagglutinin-neuraminidase	HN	0.0014
3609	Hemagglutinin-neuraminidase	HN	0.0014
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0014
3444	Cyanovirin-N	Not Available	0.0014
554	Low-density lipoprotein receptor	LDLR	0.0014
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0014
852	Heparin cofactor 2	SERPIND1	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
4787	Envelope glycoprotein gp160	env	0.0013
4820	Envelope glycoprotein gp160	env	0.0013
5727	Envelope glycoprotein gp160	env	0.0013
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0013
595	Fibrinogen alpha chain	FGA	0.0013
4031	Glutathione S-transferase A1	GSTA1	0.0013
4666	Fucose-binding lectin PA-IIL	lecB	0.0013
2372	Bifunctional tail protein	9	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
1439	Lactotransferrin	LTF	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0011
2802	Endoglucanase G	celCCG	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
2430	Chondroitinase B	cslB	0.0011
6307	Ig gamma-2 chain C region	IGHG2	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
2581	Chondroitinase AC	cslA	0.001
309	Antithrombin-III	SERPINC1	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
6847	Lactase-phlorizin hydrolase	LCT	0.001
345	Plasma retinol-binding protein	RBP4	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2132	Protein S100-B	S100B	0.0009
4785	Ig gamma-1 chain C region	IGHG1	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
1867	Major prion protein	PRNP	0.0008
1507	Cytochrome c	CYCS	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
125	DNA polymerase beta	POLB	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
909	Maleylacetoacetate isomerase	GSTZ1	0.0007
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00675 - Tamoxifen

Targets

Enzymes

Transporters

Predictions