DT-Web

DB00196 - Fluconazole


Identification
Name Fluconazole
Accession Number DB00196 (APRD00327)
Type small molecule
Description Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 306.2708
Groups approved
Monoisotopic Weight 306.104065446
Pharmacology
Indication For the treatment of fungal infections.
Mechanism of action Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Absorption 90%
Protein binding 11 to 12%
Biotransformation Hepatic
Route of elimination In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug.
Toxicity Symptoms of overdose include hallucinations and paranoid behavior.
Affected organisms
  • Fungi
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Fluconazole may increase the serum concentration of acenocoumarol by decreasing its metabolism.
Alfentanil Increases the effect and toxicity of alfentanil
Alprazolam Fluconazole may increase the effect of the benzodiazepine, alprazolam.
Amitriptyline Fluconazole may increase the effect and toxicity of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Additive QTc-prolonging effects may also occur. Monitor for changes in the therapeutic and adverse effects of amitriptyline if fluconazole is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Anisindione Fluconazole may increase the serum concentration of anisindione by decreasing its metabolism.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Bromazepam Fluconazole may increase the serum concentration of bromazepam by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of bromazepam if fluconazole is initiated, discontinued or dose changed.
Carbamazepine Fluconazole may increase the therapeutic and adverse effects of carbamazepine.
Carisoprodol Strong CYP2C19 inhibitors such as fluconazole may decrease the metabolism of CYP2C19 substrates such as carisoprodol. Consider an alternative for one of the interacting drugs in order to avoid toxicity of the substrate. Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for increased effects of the CYP substrate if a CYP inhibitor is initiated/dose increased, and decreased effects if a CYP inhibitor is discontinued/dose decreased.
Celecoxib Fluconazole may increase the effect of celecoxib.
Chlordiazepoxide Fluconazole may increase the effect of the benzodiazepine, chlordiazepoxide.
Cilostazol Fluconazole may decrease the effect of cilostazol.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clonazepam Fluconazole may increase the effect of the benzodiazepine, clonazepam.
Clorazepate Fluconazole may increase the effect of the benzodiazepine, clorazepate.
Conivaptan Antifungal Agents (Azole Derivatives, Systemic) may decrease the metabolism of Conivaptan. Concomitant use of conivaptan with strong CYP3A4 inhibitors (e.g., azole antifungals) is contraindicated.
Cyclophosphamide Fluconazole reduces metabolism and clearance of cyclophosphamide.
Cyclosporine Fluconazole may increase the therapeutic and adverse effects of the cyclosporine.
Diazepam Fluconazole may increase the effect of the benzodiazepine, diazepam.
Dicumarol Fluconazole may increase the serum concentration of dicumarol by decreasing its metabolism.
Dihydroergotamine Possible ergotism and severe ischemia with this combination
Eplerenone This CYP3A4 inhibitor increases the effect and toxicity of eplerenone
Ergotamine Possible ergotism and severe ischemia with this combination
Estazolam Fluconazole may increase the effect of the benzodiazepine, estazolam.
Ethotoin Increases the effect of hydantoin
Everolimus Fluconazole may increase everolimus levels/toxicity.
Fentanyl Fluconazole may increase levels/toxicity of fentanyl.
Fesoterodine Fluconazole is a moderate CYP3A4 inhibitor thus reducing clearance. Monitor for adverse effects when using concomitant therapy with fesoterodine.
Flurazepam Fluconazole may increase the effect of the benzodiazepine, flurazepam.
Fluvastatin Fluconazole may increase the serum concentration of fluvastatin by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of fluvastatin if fluconazole is initiated, discontinued or dose changed.
Fosphenytoin Fluconazole may increase the effect of hydantoin.
Halazepam Fluconazole may increase the effect of the benzodiazepine, halazepam.
Haloperidol Fluconazole may increase the effect and toxicity of haloperidol.
Imipramine Fluconazole may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Additive QTc-prolonging effects may also occur. Monitor for changes in the therapeutic and adverse effects of imipramine if fluconazole is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Ivacaftor Moderate CYP3A4 inhibitors may increase levels of ivacaftor. Consider dose reduction.
Lovastatin Increased risk of myopathy/rhabdomyolysis
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mephenytoin Increases the effect of hydantoin
Midazolam Fluconazole may increase the effect of the benzodiazepine, midazolam.
Nortriptyline Fluconazole may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Additive QTc-prolonging effects may also occur. Monitor for changes in the therapeutic and adverse effects of nortriptyline if fluconazole is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Ospemifene Fluconazole, a moderate CYP3A / strong CYP2C9 / moderate CYP2C19 inhibitor, should not be used with ospemifene. Fluconazole increases the systemic exposure of ospemifene by 2.7-fold. Administration of fluconazole with ospemifene may increase the risk of adverse events.
Phenytoin Fluconazole may increase the therapeutic and adverse effects of phenytoin.
Pimozide Increased risk of cardiotoxicity and arrhythmias
Quazepam Fluconazole may increase the effect of the benzodiazepine, quazepam.
Ramelteon Fluconazole may increase the serum levels and toxcity of ramelteon.
Ranolazine Increased levels of ranolazine - risk of toxicity
Rifabutin Fluconazole may increase levels/toxicity of rifabutin.
Rifampin Rifampin may decrease the effect of fluconazole.
Silodosin Strong UGT2B7 inhibitors may increase levels of silodosin. Monitor concomitant therapy closely.
Simvastatin Increased risk of myopathy/rhabdomyolysis
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution. The antifungal, fluconazole, may also increase serum concentrations of tacrolimus.
Tamoxifen Fluconzole may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Fluconazole is initiated, discontinued or dose changed.
Tamsulosin Fluconzole, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Fluconazole is initiated, discontinued, or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tipranavir Fluconazole may increase the serum concentration of Tipranavir. Dose adjustments are not required.
Tofacitinib Fluconazole (and other strong CYP2C19 inhibitors and moderate CYP3A4 inhibitors), when used in combination with tofacitinib, may increase tofacitinib concentration. It is recommended to modify therapy by reducing the adult dose of tofacitinib from 5mg twice a day to 5mg daily.
Tolbutamide Fluconazole, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Fluconazole therapeutic and adverse effects if Delavirdine is initiated, discontinued or dose changed.
Tolterodine Fluconazole may decrease the metabolism and clearance of tolterodine. Adjust tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan Fluconazole is a moderate inhibitor of CYP3A4 and will considerably increase tolvaptan serum concentrations
Torasemide Fluconazole, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Fluconazole is initiated, discontinued or dose changed.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol Fluconazole may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone The CYP3A4 inhibitor, Fluconazole, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Fluconazole is initiated, discontinued or dose changed.
Triazolam Fluconazole may increase the effect of the benzodiazepine, triazolam.
Trimethoprim The strong CYP2C9 inhibitor, Fluconazole, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Fluconazole is initiated, discontinued or dose changed.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Fluconazole, a strong CYP2C19 inhibitor, may also decrease the metabolism and clearance of Trimipramine, a CYP2C19 substrate. Concomitant therapy should be used with caution.
Valdecoxib Fluconazole may increase the effect and toxicity of valdecoxib.
Verapamil Fluconazole may increase the serum concentration of Verapamil by decreasing Verapamil metabolism. This likely occurs via Fluconazole-mediated CYP3A4 inhibition. Monitor for changes in the therapeutic/adverse effects of Verapamil if Fluconazole is initiated, discontinued, or dose changed.
Vinblastine Increases the effect and toxicity of anticancer agent
Vincristine Increases the effect and toxicity of anticancer agent
Voriconazole Fluconazole, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for QTc prolongation and changes in the therapeutic and adverse effects of voriconazole if fluconazole is initiated, discontinued or dose changed.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin Fluconazole, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if fluconazole is initiated, discontinued or dose changed.
Zafirlukast Fluconazole, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of zafirlukast. Consider alternate therapy or monitor for changes in zafirlukast therapeutic and adverse effects if fluconazole is initiated, discontinued or dose changed.
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolpidem Fluconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if fluconazole is initiated, discontinued or dose changed.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take without regard to meals.

Targets


Cytochrome P450 51
Name Cytochrome P450 51
Gene Name ERG11
Pharmacological action yes
Actions inhibitor
References
  • Bellamine A, Lepesheva GI, Waterman MR: Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology. J Lipid Res. 2004 Nov;45(11):2000-7. Epub 2004 Aug 16. - Pubmed
  • Guinea J, Sanchez-Somolinos M, Cuevas O, Pelaez T, Bouza E: Fluconazole resistance mechanisms in Candida krusei: the contribution of efflux-pumps. Med Mycol. 2006 Sep;44(6):575-8. - Pubmed
  • Chau AS, Chen G, McNicholas PM, Mann PA: Molecular basis for enhanced activity of posaconazole against Absidia corymbifera and Rhizopus oryzae. Antimicrob Agents Chemother. 2006 Nov;50(11):3917-9. Epub 2006 Sep 11. - Pubmed
DTHybrid score 0.4524

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. - Pubmed
  • Kunze KL, Wienkers LC, Thummel KE, Trager WF: Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies. Drug Metab Dispos. 1996 Apr;24(4):414-21. - Pubmed
  • Sakaeda T, Iwaki K, Kakumoto M, Nishikawa M, Niwa T, Jin JS, Nakamura T, Nishiguchi K, Okamura N, Okumura K: Effect of micafungin on cytochrome P450 3A4 and multidrug resistance protein 1 activities, and its comparison with azole antifungal drugs. J Pharm Pharmacol. 2005 Jun;57(6):759-64. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7235
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. - Pubmed
  • Kunze KL, Wienkers LC, Thummel KE, Trager WF: Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies. Drug Metab Dispos. 1996 Apr;24(4):414-21. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4508
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Niwa T, Shiraga T, Takagi A: Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes. Biol Pharm Bull. 2005 Sep;28(9):1805-8. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4447
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions inhibitor
References
DTHybrid score 0.4298
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions inhibitor
References
DTHybrid score 0.3509
Cytochrome P450 11B1, mitochondrial
Name Cytochrome P450 11B1, mitochondrial
Gene Name CYP11B1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2039

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW: Interaction of common azole antifungals with P glycoprotein. Antimicrob Agents Chemother. 2002 Jan;46(1):160-5. - Pubmed
  • Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed
  • Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed
DTHybrid score 0.4665

Predictions


Id Partner name Gene Name Score
761 Cytochrome P450 51 ERG11 0.4524
3163 Cytochrome P450 51 cyp51 0.4524
4119 Cytochrome P450 2D6 CYP2D6 0.3045
4924 Cytochrome P450 2C8 CYP2C8 0.2618
4200 Cytochrome P450 1A2 CYP1A2 0.2407
6030 Cytochrome P450 2B6 CYP2B6 0.1777
6013 Cytochrome P450 2E1 CYP2E1 0.1698
5718 Cytochrome P450 2A6 CYP2A6 0.1057
3811 Cytochrome P450 19A1 CYP19A1 0.1029
1010 Cytochrome P450 51A1 CYP51A1 0.1011
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0992
6024 Cytochrome P450 1A1 CYP1A1 0.0989
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0966
587 Serum albumin ALB 0.0912
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0874
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0864
20 Prostaglandin G/H synthase 1 PTGS1 0.0824
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0627
6106 Cytochrome P450 2C18 CYP2C18 0.0612
862 Multidrug resistance-associated protein 1 ABCC1 0.0583
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0543
492 Histamine H1 receptor HRH1 0.0518
776 Bile salt export pump ABCB11 0.0476
824 Sodium-dependent serotonin transporter SLC6A4 0.0474
6145 Solute carrier family 22 member 1 SLC22A1 0.0471
1729 Solute carrier family 22 member 6 SLC22A6 0.0453
831 D(2) dopamine receptor DRD2 0.0444
1898 Cytochrome P450 1B1 CYP1B1 0.0439
756 Sex hormone-binding globulin SHBG 0.0434
871 Glucocorticoid receptor NR3C1 0.0433
737 Mineralocorticoid receptor NR3C2 0.0417
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0411
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0409
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0408
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0403
6144 Solute carrier family 22 member 2 SLC22A2 0.0402
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.04
847 Mu-type opioid receptor OPRM1 0.0395
290 Prostaglandin G/H synthase 2 PTGS2 0.0386
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0371
380 Cytochrome P450 17A1 CYP17A1 0.037
103 Muscarinic acetylcholine receptor M1 CHRM1 0.037
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0369
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0365
556 Alpha-1A adrenergic receptor ADRA1A 0.0362
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0362
6031 Cytochrome P450 3A43 CYP3A43 0.036
502 5-hydroxytryptamine 2A receptor HTR2A 0.036
269 Adrenodoxin, mitochondrial FDX1 0.0358
232 Corticosteroid-binding globulin SERPINA6 0.0342
731 HIV-1 protease HIV-1 protease 0.034
118 Organic cation/carnitine transporter 2 SLC22A5 0.0334
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0326
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0323
320 5-hydroxytryptamine 1A receptor HTR1A 0.0323
6143 Solute carrier family 22 member 7 SLC22A7 0.0318
136 Estrogen receptor ESR1 0.03
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0293
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0292
467 Delta-type opioid receptor OPRD1 0.0292
6142 Solute carrier family 22 member 8 SLC22A8 0.0291
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0279
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0273
696 Kappa-type opioid receptor OPRK1 0.0263
766 Beta-2 adrenergic receptor ADRB2 0.0262
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0262
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0258
629 Alpha-2B adrenergic receptor ADRA2B 0.0257
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0257
146 Androgen receptor AR 0.0255
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0255
632 Alpha-1B adrenergic receptor ADRA1B 0.0253
318 Alpha-2A adrenergic receptor ADRA2A 0.0252
2164 Multidrug resistance-associated protein 4 ABCC4 0.025
6182 Cytochrome P450 2J2 CYP2J2 0.0243
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0239
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0239
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0238
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0238
713 Sodium-dependent dopamine transporter SLC6A3 0.0237
23 D(1A) dopamine receptor DRD1 0.0231
817 DNA topoisomerase 2-alpha TOP2A 0.023
614 Progesterone receptor PGR 0.023
341 5-hydroxytryptamine 3 receptor HTR3A 0.0227
590 5-hydroxytryptamine 2C receptor HTR2C 0.0227
94 5-hydroxytryptamine 4 receptor HTR4 0.0225
6147 Solute carrier family 22 member 3 SLC22A3 0.0219
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0217
638 D(3) dopamine receptor DRD3 0.021
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0209
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0207
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0207
193 Beta-1 adrenergic receptor ADRB1 0.0204
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0203
6148 Multidrug resistance-associated protein 7 ABCC10 0.0199
122 P2Y purinoceptor 12 P2RY12 0.0197
468 Cytochrome P450 4A11 CYP4A11 0.0193
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0191
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0191
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0182
3941 Amine oxidase [flavin-containing] A MAOA 0.0179
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0177
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0177
885 5-hydroxytryptamine 1B receptor HTR1B 0.0174
833 Organic cation/carnitine transporter 1 SLC22A4 0.0173
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0173
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0172
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0171
3923 Cholinesterase BCHE 0.017
4148 Serine/threonine-protein kinase mTOR MTOR 0.0169
124 Histamine H2 receptor HRH2 0.0169
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0169
789 Alpha-1D adrenergic receptor ADRA1D 0.0168
1024 Solute carrier family 22 member 11 SLC22A11 0.0165
844 Epidermal growth factor receptor EGFR 0.0165
465 Calmodulin CALM1 0.0164
811 Translocator protein TSPO 0.016
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.016
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0159
469 Annexin A1 ANXA1 0.0157
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0155
4604 Liver carboxylesterase 1 CES1 0.0153
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0153
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0151
3939 Amine oxidase [flavin-containing] B MAOB 0.015
70 Type-1 angiotensin II receptor AGTR1 0.0147
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0147
725 5-hydroxytryptamine 1D receptor HTR1D 0.0146
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0146
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0145
504 Mast/stem cell growth factor receptor KIT 0.0144
6137 Multidrug resistance-associated protein 6 ABCC6 0.0141
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0141
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0141
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0141
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0141
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0141
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0141
5934 Cytochrome P450 26A1 CYP26A1 0.014
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0138
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0138
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0138
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0138
378 Alpha-2C adrenergic receptor ADRA2C 0.0136
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0136
818 50S ribosomal protein L10 rplJ 0.0135
407 Vascular endothelial growth factor receptor 2 KDR 0.0134
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0134
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0133
891 Dihydropteroate synthase folP 0.0132
5359 Dihydropteroate synthase folP 0.0132
7175 Dihydropteroate synthase sulI 0.0132
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0132
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.013
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.013
6136 Multidrug resistance-associated protein 5 ABCC5 0.0129
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0129
26 Vascular endothelial growth factor receptor 3 FLT4 0.0129
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0128
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0128
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0128
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0128
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0127
4120 NADPH--cytochrome P450 reductase POR 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
6141 Sodium/bile acid cotransporter SLC10A1 0.0125
32 Vascular endothelial growth factor receptor 1 FLT1 0.0123
29 Tubulin beta-1 chain TUBB1 0.0123
777 Tumor necrosis factor TNF 0.0123
432 D(4) dopamine receptor DRD4 0.0122
161 Tubulin beta chain TUBB 0.0122
312 Tubulin beta chain TUB2 0.0122
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0121
2298 Cytochrome P450-cam camC 0.0121
228 Beta platelet-derived growth factor receptor PDGFRB 0.012
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0118
427 Substance-P receptor TACR1 0.0117
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0117
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0116
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0115
716 5-hydroxytryptamine 7 receptor HTR7 0.0114
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0114
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0114
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.011
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.011
477 DNA topoisomerase 4 subunit A parC 0.0109
886 DNA topoisomerase 4 subunit A parC 0.0109
6226 DNA topoisomerase 4 subunit A parC 0.0109
6220 Aryl hydrocarbon receptor AHR 0.0108
404 DNA gyrase subunit A gyrA 0.0108
6224 DNA gyrase subunit A gyrA 0.0108
1656 CYP2B protein CYP2B 0.0107
952 Dipeptidyl peptidase 4 DPP4 0.0106
869 Estrogen receptor beta ESR2 0.0105
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0104
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0103
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0101
768 FK506-binding protein 1A FKBP1A 0.01
436 5-hydroxytryptamine 2B receptor HTR2B 0.0098
2539 Tubulin alpha-1 chain TUBA4A 0.0098
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0097
49 Endothelin B receptor EDNRB 0.0096
4237 50S ribosomal protein L22 rplV 0.0095
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0093
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0092
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0092
578 Endothelin-1 receptor EDNRA 0.009
592 Carbonic anhydrase 4 CA4 0.009
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0089
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0089
295 Carbonic anhydrase 1 CA1 0.0088
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
1192 Sulfotransferase 1A1 SULT1A1 0.0087
6102 Arylamine N-acetyltransferase 2 NAT2 0.0087
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0085
7 Nitric oxide synthase, inducible NOS2 0.0085
474 Acetylcholinesterase ACHE 0.0084
1852 Microtubule-associated protein 2 MAP2 0.0084
4238 50S ribosomal protein L4 rplD 0.0083
5578 50S ribosomal protein L4 rplD 0.0083
6173 50S ribosomal protein L4 rplD 0.0083
6219 50S ribosomal protein L4 rplD 0.0083
528 5-hydroxytryptamine 1E receptor HTR1E 0.0081
1256 5-hydroxytryptamine 6 receptor HTR6 0.008
1353 DNA topoisomerase 1 TOP1 0.008
3552 DNA topoisomerase 1 topA 0.008
6020 Aldehyde oxidase AOX1 0.008
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0079
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0077
738 Monocarboxylate transporter 1 SLC16A1 0.0076
165 FL cytokine receptor FLT3 0.0076
208 DNA-directed RNA polymerase beta' chain rpoC 0.0075
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0075
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0074
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0074
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0073
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0073
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0073
705 Glutamate receptor 1 GRIA1 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
239 Coagulation factor X F10 0.0072
5300 Antigen peptide transporter 1 TAP1 0.0072
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0072
1757 Myeloperoxidase MPO 0.0072
6014 Cytochrome P450 2A13 CYP2A13 0.0071
54 Prothrombin F2 0.0071
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0071
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.007
373 Transthyretin TTR 0.007
319 Opioid receptor, sigma 1 OPRS1 0.007
273 Apoptosis regulator Bcl-2 BCL2 0.0069
6085 Fatty acid-binding protein, intestinal FABP2 0.0068
244 Angiotensin-converting enzyme ACE 0.0068
68 Cannabinoid receptor 1 CNR1 0.0068
814 Ryanodine receptor 1 RYR1 0.0068
357 Carbonic anhydrase 2 CA2 0.0067
163 D(1B) dopamine receptor DRD5 0.0067
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0066
365 Dihydrofolate reductase DHFR 0.0066
2381 Dihydrofolate reductase DFR1 0.0066
2833 Dihydrofolate reductase Not Available 0.0066
2931 Dihydrofolate reductase folA 0.0066
3544 Dihydrofolate reductase folA 0.0066
3682 Dihydrofolate reductase folA 0.0066
6642 Dihydrofolate reductase folA 0.0066
6756 Dihydrofolate reductase dfrA 0.0066
291 Nitric-oxide synthase, endothelial NOS3 0.0066
1196 Complement decay-accelerating factor CD55 0.0065
5923 Microtubule-associated protein tau MAPT 0.0064
5924 Microtubule-associated protein 4 MAP4 0.0064
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0063
3810 Catechol O-methyltransferase COMT 0.0063
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0063
133 Dihydropterate synthase sulI 0.0063
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0062
183 Vascular endothelial growth factor A VEGFA 0.0061
823 Fibroblast growth factor receptor 2 FGFR2 0.0061
1618 High affinity nerve growth factor receptor NTRK1 0.0061
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.006
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0058
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0058
921 Glutamate receptor 2 GRIA2 0.0058
1483 Membrane copper amine oxidase AOC3 0.0057
4203 Histamine N-methyltransferase HNMT 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
153 Dopamine beta-hydroxylase DBH 0.0057
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0057
2808 Chloramphenicol acetyltransferase 3 cat3 0.0056
2449 Tubulin alpha-3 chain TUBA1A 0.0056
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0056
275 Arachidonate 5-lipoxygenase ALOX5 0.0056
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0056
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0056
6174 50S ribosomal protein L32 rpmF 0.0056
780 Retinoic acid receptor RXR-gamma RXRG 0.0056
3947 Xanthine dehydrogenase/oxidase XDH 0.0056
4773 Deoxycytidine kinase DCK 0.0055
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0055
84 Nuclear receptor 0B1 NR0B1 0.0055
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0054
24 Thymidylate synthase TMP1 0.0054
359 Thymidylate synthase TYMS 0.0054
2626 Thymidylate synthase thyA 0.0054
2729 Thymidylate synthase thyA 0.0054
5352 Thymidylate synthase THYA 0.0054
1178 Adenosine A2a receptor ADORA2A 0.0054
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0053
6138 Multidrug resistance protein 3 ABCB4 0.0053
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0052
284 DNA-directed RNA polymerase beta chain rpoB 0.0052
5773 DNA-directed RNA polymerase beta chain rpoB 0.0052
3601 Dihydropteroate synthase 1 folP1 0.0052
3807 Dihydropteroate synthase 1 folP1 0.0052
3808 Dihydropteroate synthase 2 folP2 0.0052
6126 Carbonic anhydrase 7 CA7 0.0052
2417 Chloramphenicol acetyltransferase cat 0.0052
3278 Chloramphenicol acetyltransferase cat 0.0052
88 Retinoic acid receptor RXR-beta RXRB 0.0051
2810 Dr hemagglutinin structural subunit draA 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.005
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
1630 Integrin beta-2 ITGB2 0.005
4122 Histone deacetylase 2 HDAC2 0.005
1050 Bile salt sulfotransferase SULT2A1 0.005
976 Platelet glycoprotein IX GP9 0.005
1517 Beta-3 adrenergic receptor ADRB3 0.005
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0049
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0048
856 Vitamin D3 receptor VDR 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
16 Adenosine A1 receptor ADORA1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0045
174 Sigma 1-type opioid receptor SIGMAR1 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1275 Estrogen sulfotransferase SULT1E1 0.0043
6432 Transporter snf 0.0043
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0043
4103 Proteasome subunit beta type 2 PSMB2 0.0043
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
4102 Proteasome subunit beta type 5 PSMB5 0.0043
4101 Proteasome subunit beta type 1 PSMB1 0.0043
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
482 Glycine receptor subunit alpha-1 GLRA1 0.0042
3809 Estrogen-related receptor gamma ESRRG 0.0042
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0042
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0042
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0042
6043 Putative G-protein coupled receptor 44 GPR44 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
6044 Serum paraoxonase/lactonase 3 PON3 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
4311 tRNA TRDMT1 0.0041
4325 tRNA trmD 0.0041
4328 tRNA trmD 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
904 Glutathione S-transferase P GSTP1 0.0041
106 Cannabinoid receptor 2 CNR2 0.004
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
1629 Transcription factor AP-1 JUN 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
1541 Metalloproteinase mmp20 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0038
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0038
33 Cystine/glutamate transporter SLC7A11 0.0038
572 Integrin alpha-L ITGAL 0.0038
85 Growth hormone receptor GHR 0.0038
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0037
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0037
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
1864 RET proto-oncogene RET 0.0037
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0036
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0036
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0036
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0036
2112 Toll-like receptor 9 TLR9 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6048 Troponin C, skeletal muscle TNNC2 0.0036
6149 Solute carrier family 22 member 10 SLC22A10 0.0035
5787 Angiopoietin-1 receptor TEK 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
511 5-hydroxytryptamine 1F receptor HTR1F 0.0034
558 Solute carrier family 12 member 1 SLC12A1 0.0033
6824 Tyrosine-protein kinase Lyn LYN 0.0033
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0033
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0033
936 Ephrin type-A receptor 2 EPHA2 0.0032
581 Cytochrome P450 2R1 CYP2R1 0.0032
267 Plasminogen activator inhibitor 1 SERPINE1 0.0032
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0032
3086 Plasmepsin-2 Not Available 0.0032
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0032
518 Peroxidase/catalase T katG 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2981 Phospholipase A2, membrane associated PLA2G2A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.003
4192 DNA topoisomerase 2-beta TOP2B 0.003
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.003
719 Retinoic acid receptor responder protein 1 RARRES1 0.003
770 Retinoic acid-induced protein 3 GPRC5A 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0029
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
563 Thyroid peroxidase TPO 0.0028
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0028
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0028
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
634 Squalene monooxygenase SQLE 0.0027
7196 Squalene monooxygenase ERG1 0.0027
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
162 Retinoic acid receptor gamma-1 RARG 0.0026
569 Retinal dehydrogenase 2 ALDH1A2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
6146 High affinity copper uptake protein 1 SLC31A1 0.0025
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
605 Fumarate reductase flavoprotein subunit frdA 0.0025
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0025
3673 Fumarate reductase flavoprotein subunit fccA 0.0025
4912 Fumarate reductase flavoprotein subunit ifcA 0.0025
6549 Fumarate reductase flavoprotein subunit frdA 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4217 Telomerase reverse transcriptase TERT 0.0025
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0025
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0025
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0025
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
1648 Elastin ELN 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
164 Histamine H4 receptor HRH4 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
65 Matrix metalloproteinase-9 Not Available 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
1992 Vitamin D-binding protein GC 0.0021
908 Glutathione S-transferase theta-1 GSTT1 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.002
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.002
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
5798 Mitogen-activated protein kinase 11 MAPK11 0.002
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0019
1039 Histone deacetylase 9 HDAC9 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0019
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0019
444 Alcohol dehydrogenase 1B ADH1B 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
1253 Interferon gamma IFNG 0.0018
537 ATP synthase delta chain, mitochondrial ATP5D 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
2021 Thrombomodulin THBD 0.0018
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0017
251 Alcohol dehydrogenase 1A ADH1A 0.0017
6218 Pannexin-1 PANX1 0.0017
1374 Natriuretic peptides B NPPB 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
3830 Calreticulin CALR 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
820 Glycine receptor subunit alpha-2 GLRA2 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
2183 Fatty acid-binding protein, adipocyte FABP4 0.0016
3937 Fatty-acid amide hydrolase FAAH 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0016
3957 Adenosine deaminase ADA 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
517 Alcohol dehydrogenase 1C ADH1C 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
489 Monocarboxylate transporter 2 SLC16A7 0.0015
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0015
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0015
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
896 Glutathione S-transferase Mu 1 GSTM1 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0014
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1792 Tissue-type plasminogen activator PLAT 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
1360 Sphingomyelin phosphodiesterase SMPD1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6459 Glycodelin PAEP 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
3221 Cytochrome c4 cc4 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
2207 Rhodopsin RHO 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
268 Adenosine A2b receptor ADORA2B 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
4948 Cytochrome c-553 Not Available 0.0008
4923 Cytochrome c3 DvMF_2499 0.0008
4945 Cytochrome c3 Not Available 0.0008
4949 Cytochrome c3 DVU_3171 0.0008
4968 Cytochrome c3 cytc3 0.0008
4997 Cytochrome c3 SO_2727 0.0008
5219 Cytochrome c3 cyd 0.0008
4902 Nine-heme cytochrome c Ddes_2038 0.0008
3189 High-molecular-weight cytochrome c hmcA 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
6163 Copper-transporting ATPase 2 ATP7B 0.0008
6165 Copper-transporting ATPase 1 ATP7A 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
760 Fibroblast growth factor 1 FGF1 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
3917 Methylenetetrahydrofolate reductase MTHFR 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
125 DNA polymerase beta POLB 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1507 Cytochrome c CYCS 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4943 Cytochrome c6 petJ 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
5000 HemO hemO 0.0003
4910 Cytoglobin CYGB 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4909 CooA protein cooA 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4942 Diheme cytochrome c napB napB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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