DT-Web

DB00696 - Ergotamine


Identification
Name Ergotamine
Accession Number DB00696 (APRD00677)
Type small molecule
Description A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 581.6615
Groups approved
Monoisotopic Weight 581.263819255
Pharmacology
Indication For use as therapy to abort or prevent vascular headache, e.g., migraine, migraine variants, or so called "histaminic cephalalgia".
Mechanism of action Ergotamine acts on migraine by one of two proposed mechanisms: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache, and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
Absorption The bioavailability of sublingually administered ergotamine has not been determined.
Protein binding Not Available
Biotransformation Hepatic. Ergotamine is metabolized by the liver by largely undefined pathways, and 90% of the metabolites are excreted in the bile.
Route of elimination Not Available
Toxicity Signs of overexposure include irritation, nausea, vomiting, headache, diarrhea, thirst, coldness of skin, pruritus, weak pulse, numbness, tingling of extremities, and confusion.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Ischemia with risk of gangrene
Almotriptan Possible severe and prolonged vasoconstriction
Amprenavir Amprenavir may increase the effect and toxicity of ergotamine.
Amyl Nitrite Possible antagonism of action
Atazanavir Atazanavir may increase the effect and toxicity of ergotamine.
Atenolol Ischemia with risk of gangrene
Betaxolol Ischemia with risk of gangrene
Bevantolol Ischemia with risk of gangrene
Bisoprolol Ischemia with risk of gangrene
Carteolol Ischemia with risk of gangrene
Carvedilol Ischemia with risk of gangrene
Clarithromycin Risk of ergotism and severe ischemia with this association
Delavirdine The antiretroviral agent may increase the ergot derivative toxicity
Desvenlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Efavirenz The antiretroviral agent may increase the ergot derivative toxicity
Eletriptan Possible severe and prolonged vasoconstriction
Erythrityl Tetranitrate Possible antagonism of action
Erythromycin Possible ergotism and severe ischemia with this combination
Esmolol Ischemia with risk of gangrene
Fluconazole Possible ergotism and severe ischemia with this combination
Fluoxetine Possible ergotism and severe ischemia with this combination
Fluvoxamine Possible ergotism and severe ischemia with this combination
Fosamprenavir Amprenavir increases the effect and toxicity of ergot derivative
Frovatriptan Possible severe and prolonged vasoconstriction
Indinavir Indinavir may increase the serum concentration of ergotamine. Concomitant therapy is contraindicated.
Isosorbide Dinitrate Possible antagonism of action
Isosorbide Mononitrate Possible antagonism of action
Itraconazole Possible ergotism and severe ischemia with this combination
Josamycin Possible ergotism and severe ischemia with this combination
Ketoconazole Possible ergotism and severe ischemia with this combination.
Labetalol Ischemia with risk of gangrene
Lorcaserin Avoid all combinations with any ergot derivative such as ergotamine. The combination can increase the risk of developing serotonin syndrome and/or valvular heart disease.
Metoprolol Ischemia with risk of gangrene
Nadolol Ischemia with risk of gangrene
Naratriptan Possible severe and prolonged vasoconstriction.
Nefazodone Possible ergotism and severe ischemia with this combination
Nelfinavir Nelfinavir increases the effect and toxicity of ergot derivative
Nitroglycerin Possible antagonism of action
Oxprenolol Ischemia with risk of gangrene
Penbutolol Ischemia with risk of gangrene
Pentaerythritol Tetranitrate Possible antagonism of action
Pindolol Ischemia with risk of gangrene
Posaconazole Contraindicated co-administration
Practolol Ischemia with risk of gangrene
Propranolol Ischemia with risk of gangrene
Ritonavir The protease inhibitor, ritonavir, may increase the effect and toxicity of the ergot derivative, ergotamine.
Rizatriptan Possible severe and prolonged vasoconstriction
Saquinavir The protease inhibitor, saquinavir, may increase the effect and toxicity of the ergot derivative, ergotamine.
Sibutramine Possible serotoninergic syndrome with this combination
Sotalol Ischemia with risk of gangrene
Sumatriptan Possible severe and prolonged vasoconstriction
Telaprevir Telaprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Telithromycin Telithromycin may reduce clearance of Ergotamine. Concomitant therapy is contraindicated.
Timolol Ischemia with risk of gangrene
Tipranavir Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Ergotamine. Concomitant therapy is contraindicated.
Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Tranylcypromine Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trazodone Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Troleandomycin Possible ergotism and severe ischemia with this combination
Venlafaxine Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of ergotamine by decreasing its metabolism. Concomitant therapy is contraindicated.
Zileuton Possible ergotism and severe ischemia with this combination
Zolmitriptan Concomitant use of the serotonin 5-HT1D receptor agonist, zolmitriptan, and the ergot derivative, ergotamine, may result in additive vasoconstrictive effects. Concomitant use within 24 hours is contraindicated.
Food Interactions
  • Take without regard to meals.
  • Caffeine increases absorption.

Targets


5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action yes
Actions agonist
References
  • Silberstein SD, McCrory DC: Ergotamine and dihydroergotamine: history, pharmacology, and efficacy. Headache. 2003 Feb;43(2):144-66. - Pubmed
  • Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG: Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2184-8. - Pubmed
  • Hoyer D, Lery H, Waeber C, Bruinvels AT, Nozulak J, Palacios JM: - 5-HT1R
  • Sanchez-Lopez A, Centurion D, Vazquez E, Arulmani U, Saxena PR, Villalon CM: Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. Br J Pharmacol. 2003 Oct;140(4):725-35. Epub 2003 Sep 22. - Pubmed
  • Deliganis AV, Peroutka SJ: 5-Hydroxtryptamine1D receptor agonism predicts antimigraine efficacy. Headache. 1991 Apr;31(4):228-31. - Pubmed
DTHybrid score 0.3664
5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action yes
Actions agonist
References
  • Villalon CM, De Vries P, Rabelo G, Centurion D, Sanchez-Lopez A, Saxena P: Canine external carotid vasoconstriction to methysergide, ergotamine and dihydroergotamine: role of 5-HT1B/1D receptors and alpha2-adrenoceptors. Br J Pharmacol. 1999 Feb;126(3):585-94. - Pubmed
  • Willems EW, Trion M, De Vries P, Heiligers JP, Villalon CM, Saxena PR: Pharmacological evidence that alpha1-and alpha2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs. Br J Pharmacol. 1999 Jul;127(5):1263-71. - Pubmed
  • Cohen ML, Schenck K: Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha). Br J Pharmacol. 2000 Oct;131(3):562-8. - Pubmed
  • Valdivia LF, Centurion D, Arulmani U, Saxena PR, Villalon CM: 5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jul;370(1):46-53. Epub 2004 Jun 29. - Pubmed
DTHybrid score 0.3726
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions agonist
References
  • Bom AH, Heiligers JP, Saxena PR, Verdouw PD: Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5-HT1-like or 5-HT2 receptors. Br J Pharmacol. 1989 Jun;97(2):383-90. - Pubmed
  • Panconesi A, Anselmi B, Curradi C, Perfetto F, Piluso A, Franchi G: Comparison between venoconstrictor effects of sumatriptan and ergotamine in migraine patients. Headache. 1994 Apr;34(4):194-7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.493
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action unknown
Actions agonist
References
  • Verhoeff NP, Visser WH, Ferrari MD, Saxena PR, van Royen EA: Dopamine D2-receptor imaging with 123I-iodobenzamide SPECT in migraine patients abusing ergotamine: does ergotamine cross the blood brain barrier? Cephalalgia. 1993 Oct;13(5):325-9. - Pubmed
  • Larson BT, Samford MD, Camden JM, Piper EL, Kerley MS, Paterson JA, Turner JT: Ergovaline binding and activation of D2 dopamine receptors in GH4ZR7 cells. J Anim Sci. 1995 May;73(5):1396-400. - Pubmed
DTHybrid score 0.5261
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions partial agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gornemann T, Jahnichen S, Schurad B, Latte KP, Horowski R, Tack J, Flieger M, Pertz HH: Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):321-30. Epub 2007 Dec 8. - Pubmed
DTHybrid score 0.7673
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action yes
Actions partial agonist
References
  • Gornemann T, Jahnichen S, Schurad B, Latte KP, Horowski R, Tack J, Flieger M, Pertz HH: Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):321-30. Epub 2007 Dec 8. - Pubmed
DTHybrid score 0.5363
Alpha-1D adrenergic receptor
Name Alpha-1D adrenergic receptor
Gene Name ADRA1D
Pharmacological action yes
Actions partial agonist
References
  • Gornemann T, Jahnichen S, Schurad B, Latte KP, Horowski R, Tack J, Flieger M, Pertz HH: Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):321-30. Epub 2007 Dec 8. - Pubmed
DTHybrid score 0.3684
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions partial agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gornemann T, Jahnichen S, Schurad B, Latte KP, Horowski R, Tack J, Flieger M, Pertz HH: Pharmacological properties of a wide array of ergolines at functional alpha(1)-adrenoceptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):321-30. Epub 2007 Dec 8. - Pubmed
DTHybrid score 0.6335
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action unknown
Actions agonist,partial agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3985
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.472

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6582
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5029

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed
  • Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed
DTHybrid score 0.4604

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.4691
23 D(1A) dopamine receptor DRD1 0.3493
320 5-hydroxytryptamine 1A receptor HTR1A 0.343
378 Alpha-2C adrenergic receptor ADRA2C 0.3376
590 5-hydroxytryptamine 2C receptor HTR2C 0.2788
638 D(3) dopamine receptor DRD3 0.2334
824 Sodium-dependent serotonin transporter SLC6A4 0.2208
432 D(4) dopamine receptor DRD4 0.2165
6016 Cytochrome P450 2C19 CYP2C19 0.2075
4757 Cytochrome P450 2C9 CYP2C9 0.1999
492 Histamine H1 receptor HRH1 0.1876
713 Sodium-dependent dopamine transporter SLC6A3 0.1873
163 D(1B) dopamine receptor DRD5 0.1845
4118 Cytochrome P450 3A5 CYP3A5 0.1786
436 5-hydroxytryptamine 2B receptor HTR2B 0.1735
3941 Amine oxidase [flavin-containing] A MAOA 0.1476
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1409
716 5-hydroxytryptamine 7 receptor HTR7 0.1311
6107 Cytochrome P450 3A7 CYP3A7 0.1274
6013 Cytochrome P450 2E1 CYP2E1 0.1262
4924 Cytochrome P450 2C8 CYP2C8 0.125
6030 Cytochrome P450 2B6 CYP2B6 0.1204
193 Beta-1 adrenergic receptor ADRB1 0.1176
766 Beta-2 adrenergic receptor ADRB2 0.117
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1147
450 Muscarinic acetylcholine receptor M4 CHRM4 0.1116
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1089
51 Muscarinic acetylcholine receptor M3 CHRM3 0.1081
617 Muscarinic acetylcholine receptor M2 CHRM2 0.107
511 5-hydroxytryptamine 1F receptor HTR1F 0.1067
6145 Solute carrier family 22 member 1 SLC22A1 0.1055
6024 Cytochrome P450 1A1 CYP1A1 0.0964
587 Serum albumin ALB 0.0908
1256 5-hydroxytryptamine 6 receptor HTR6 0.0893
131 Synaptic vesicular amine transporter SLC18A2 0.0873
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0796
6144 Solute carrier family 22 member 2 SLC22A2 0.0729
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0695
341 5-hydroxytryptamine 3 receptor HTR3A 0.0632
528 5-hydroxytryptamine 1E receptor HTR1E 0.0625
1517 Beta-3 adrenergic receptor ADRB3 0.0583
5718 Cytochrome P450 2A6 CYP2A6 0.0567
6147 Solute carrier family 22 member 3 SLC22A3 0.0506
118 Organic cation/carnitine transporter 2 SLC22A5 0.0461
3923 Cholinesterase BCHE 0.0461
3939 Amine oxidase [flavin-containing] B MAOB 0.0458
828 Phenylalanine-4-hydroxylase PAH 0.0441
3109 Phenylalanine-4-hydroxylase phhA 0.0441
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0436
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0435
20 Prostaglandin G/H synthase 1 PTGS1 0.0402
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0385
465 Calmodulin CALM1 0.0377
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0373
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0365
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0347
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0344
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0334
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0331
3811 Cytochrome P450 19A1 CYP19A1 0.0327
124 Histamine H2 receptor HRH2 0.0319
862 Multidrug resistance-associated protein 1 ABCC1 0.03
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0291
871 Glucocorticoid receptor NR3C1 0.0283
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0274
6106 Cytochrome P450 2C18 CYP2C18 0.0274
1898 Cytochrome P450 1B1 CYP1B1 0.0269
94 5-hydroxytryptamine 4 receptor HTR4 0.0267
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0265
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0263
6138 Multidrug resistance protein 3 ABCB4 0.0262
36 Insulin receptor INSR 0.0258
1636 Trace amine-associated receptor 1 TAAR1 0.0258
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0244
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0238
474 Acetylcholinesterase ACHE 0.0238
1729 Solute carrier family 22 member 6 SLC22A6 0.0235
776 Bile salt export pump ABCB11 0.0227
696 Kappa-type opioid receptor OPRK1 0.0225
136 Estrogen receptor ESR1 0.0223
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0218
847 Mu-type opioid receptor OPRM1 0.0217
6070 Nischarin NISCH 0.0217
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0214
6020 Aldehyde oxidase AOX1 0.0213
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0213
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0211
467 Delta-type opioid receptor OPRD1 0.0204
174 Sigma 1-type opioid receptor SIGMAR1 0.0203
833 Organic cation/carnitine transporter 1 SLC22A4 0.0199
817 DNA topoisomerase 2-alpha TOP2A 0.0198
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0196
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0196
290 Prostaglandin G/H synthase 2 PTGS2 0.0194
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0189
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0184
477 DNA topoisomerase 4 subunit A parC 0.0181
886 DNA topoisomerase 4 subunit A parC 0.0181
6226 DNA topoisomerase 4 subunit A parC 0.0181
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0179
404 DNA gyrase subunit A gyrA 0.0178
6224 DNA gyrase subunit A gyrA 0.0178
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0172
220 Sodium channel protein type 5 subunit alpha SCN5A 0.017
6432 Transporter snf 0.017
1656 CYP2B protein CYP2B 0.0165
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0158
731 HIV-1 protease HIV-1 protease 0.0158
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0155
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0154
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0151
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0151
923 Glutamate receptor 3 GRIA3 0.0149
6151 Monocarboxylate transporter 10 SLC16A10 0.0144
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0142
6142 Solute carrier family 22 member 8 SLC22A8 0.014
6182 Cytochrome P450 2J2 CYP2J2 0.0139
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0138
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0138
233 Potassium channel subfamily K member 2 KCNK2 0.0137
6143 Solute carrier family 22 member 7 SLC22A7 0.0135
4120 NADPH--cytochrome P450 reductase POR 0.0133
260 Cytochrome P450 51 ERG11 0.0133
761 Cytochrome P450 51 ERG11 0.0133
3163 Cytochrome P450 51 cyp51 0.0133
3426 Glutamine synthetase glnA 0.0133
3987 Glutamine synthetase GLUL 0.0133
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0129
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0126
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0126
3947 Xanthine dehydrogenase/oxidase XDH 0.0126
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0123
921 Glutamate receptor 2 GRIA2 0.0121
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0117
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0116
3810 Catechol O-methyltransferase COMT 0.0115
818 50S ribosomal protein L10 rplJ 0.0115
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0114
2164 Multidrug resistance-associated protein 4 ABCC4 0.0111
164 Histamine H4 receptor HRH4 0.0109
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0108
614 Progesterone receptor PGR 0.0106
6859 Protein S100-A4 S100A4 0.0101
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.01
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0097
777 Tumor necrosis factor TNF 0.0094
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0093
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0092
380 Cytochrome P450 17A1 CYP17A1 0.0092
232 Corticosteroid-binding globulin SERPINA6 0.0091
6148 Multidrug resistance-associated protein 7 ABCC10 0.009
122 P2Y purinoceptor 12 P2RY12 0.009
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0089
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0088
4604 Liver carboxylesterase 1 CES1 0.0088
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0087
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
1757 Myeloperoxidase MPO 0.0087
468 Cytochrome P450 4A11 CYP4A11 0.0086
1618 High affinity nerve growth factor receptor NTRK1 0.0086
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0086
844 Epidermal growth factor receptor EGFR 0.0086
869 Estrogen receptor beta ESR2 0.0085
16 Adenosine A1 receptor ADORA1 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0083
1178 Adenosine A2a receptor ADORA2A 0.0079
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0078
952 Dipeptidyl peptidase 4 DPP4 0.0077
504 Mast/stem cell growth factor receptor KIT 0.0076
904 Glutathione S-transferase P GSTP1 0.0076
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0076
6137 Multidrug resistance-associated protein 6 ABCC6 0.0075
427 Substance-P receptor TACR1 0.0075
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0075
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0075
161 Tubulin beta chain TUBB 0.0073
312 Tubulin beta chain TUB2 0.0073
4237 50S ribosomal protein L22 rplV 0.0073
6031 Cytochrome P450 3A43 CYP3A43 0.0072
756 Sex hormone-binding globulin SHBG 0.0072
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0071
6220 Aryl hydrocarbon receptor AHR 0.0071
1192 Sulfotransferase 1A1 SULT1A1 0.007
2449 Tubulin alpha-3 chain TUBA1A 0.007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.007
26 Vascular endothelial growth factor receptor 3 FLT4 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
407 Vascular endothelial growth factor receptor 2 KDR 0.0068
1024 Solute carrier family 22 member 11 SLC22A11 0.0068
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0067
32 Vascular endothelial growth factor receptor 1 FLT1 0.0066
70 Type-1 angiotensin II receptor AGTR1 0.0066
29 Tubulin beta-1 chain TUBB1 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0064
146 Androgen receptor AR 0.0064
571 Melatonin receptor type 1A MTNR1A 0.0064
362 Melatonin receptor type 1B MTNR1B 0.0064
482 Glycine receptor subunit alpha-1 GLRA1 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
6141 Sodium/bile acid cotransporter SLC10A1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1353 DNA topoisomerase 1 TOP1 0.0063
3552 DNA topoisomerase 1 topA 0.0063
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0062
228 Beta platelet-derived growth factor receptor PDGFRB 0.0062
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0061
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.006
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0059
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0059
4238 50S ribosomal protein L4 rplD 0.0058
5578 50S ribosomal protein L4 rplD 0.0058
6173 50S ribosomal protein L4 rplD 0.0058
6219 50S ribosomal protein L4 rplD 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
373 Transthyretin TTR 0.0058
6014 Cytochrome P450 2A13 CYP2A13 0.0058
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0057
1360 Sphingomyelin phosphodiesterase SMPD1 0.0054
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0054
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0054
2981 Phospholipase A2, membrane associated PLA2G2A 0.0054
273 Apoptosis regulator Bcl-2 BCL2 0.0054
737 Mineralocorticoid receptor NR3C2 0.0053
6136 Multidrug resistance-associated protein 5 ABCC5 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
811 Translocator protein TSPO 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0052
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0052
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0051
694 Matrix protein 2 M 0.0051
284 DNA-directed RNA polymerase beta chain rpoB 0.0051
5773 DNA-directed RNA polymerase beta chain rpoB 0.0051
4122 Histone deacetylase 2 HDAC2 0.0051
613 Atrial natriuretic peptide receptor A NPR1 0.005
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.005
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.005
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.005
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.005
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0049
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0049
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0049
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0049
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0049
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0048
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0048
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0047
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
814 Ryanodine receptor 1 RYR1 0.0046
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0046
173 Toll-like receptor 7 TLR7 0.0046
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0045
68 Cannabinoid receptor 1 CNR1 0.0045
6043 Putative G-protein coupled receptor 44 GPR44 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0043
1010 Cytochrome P450 51A1 CYP51A1 0.0043
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0043
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0042
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
1852 Microtubule-associated protein 2 MAP2 0.0042
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1629 Transcription factor AP-1 JUN 0.004
239 Coagulation factor X F10 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.004
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0038
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0038
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0038
2539 Tubulin alpha-1 chain TUBA4A 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
1374 Natriuretic peptides B NPPB 0.0037
1827 Gap junction alpha-1 protein GJA1 0.0037
1908 Vascular cell adhesion protein 1 VCAM1 0.0037
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0037
6044 Serum paraoxonase/lactonase 3 PON3 0.0037
6102 Arylamine N-acetyltransferase 2 NAT2 0.0036
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0036
856 Vitamin D3 receptor VDR 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
4103 Proteasome subunit beta type 2 PSMB2 0.0035
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0035
4102 Proteasome subunit beta type 5 PSMB5 0.0035
4101 Proteasome subunit beta type 1 PSMB1 0.0035
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0035
3957 Adenosine deaminase ADA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
275 Arachidonate 5-lipoxygenase ALOX5 0.0034
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
183 Vascular endothelial growth factor A VEGFA 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0034
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
295 Carbonic anhydrase 1 CA1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0033
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0033
365 Dihydrofolate reductase DHFR 0.0033
2381 Dihydrofolate reductase DFR1 0.0033
2833 Dihydrofolate reductase Not Available 0.0033
2931 Dihydrofolate reductase folA 0.0033
3544 Dihydrofolate reductase folA 0.0033
3682 Dihydrofolate reductase folA 0.0033
6642 Dihydrofolate reductase folA 0.0033
6756 Dihydrofolate reductase dfrA 0.0033
738 Monocarboxylate transporter 1 SLC16A1 0.0033
592 Carbonic anhydrase 4 CA4 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
24 Thymidylate synthase TMP1 0.0032
359 Thymidylate synthase TYMS 0.0032
2626 Thymidylate synthase thyA 0.0032
2729 Thymidylate synthase thyA 0.0032
5352 Thymidylate synthase THYA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0031
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0031
705 Glutamate receptor 1 GRIA1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
780 Retinoic acid receptor RXR-gamma RXRG 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
319 Opioid receptor, sigma 1 OPRS1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
165 FL cytokine receptor FLT3 0.0028
6085 Fatty acid-binding protein, intestinal FABP2 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0027
88 Retinoic acid receptor RXR-beta RXRB 0.0027
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
1050 Bile salt sulfotransferase SULT2A1 0.0027
4192 DNA topoisomerase 2-beta TOP2B 0.0026
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0026
6824 Tyrosine-protein kinase Lyn LYN 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
1648 Elastin ELN 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0026
49 Endothelin B receptor EDNRB 0.0026
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
459 Retinoic acid receptor RXR-alpha RXRA 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0024
33 Cystine/glutamate transporter SLC7A11 0.0024
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0023
4311 tRNA TRDMT1 0.0023
4325 tRNA trmD 0.0023
4328 tRNA trmD 0.0023
823 Fibroblast growth factor receptor 2 FGFR2 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0022
54 Prothrombin F2 0.0022
4773 Deoxycytidine kinase DCK 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0022
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0021
2091 Endoplasmin HSP90B1 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0021
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
4203 Histamine N-methyltransferase HNMT 0.002
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.002
908 Glutathione S-transferase theta-1 GSTT1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
1820 Beta-nerve growth factor NGF 0.002
6146 High affinity copper uptake protein 1 SLC31A1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
5787 Angiopoietin-1 receptor TEK 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
518 Peroxidase/catalase T katG 0.0018
976 Platelet glycoprotein IX GP9 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
469 Annexin A1 ANXA1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
5923 Microtubule-associated protein tau MAPT 0.0018
5924 Microtubule-associated protein 4 MAP4 0.0018
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0018
1063 Signal transducer and activator of transcription 5B STAT5B 0.0018
162 Retinoic acid receptor gamma-1 RARG 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
229 Retinoic acid receptor beta RARB 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
563 Thyroid peroxidase TPO 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
1243 Cathepsin D CTSD 0.0016
634 Squalene monooxygenase SQLE 0.0016
7196 Squalene monooxygenase ERG1 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0016
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
3233 Bile acid receptor NR1H4 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
3809 Estrogen-related receptor gamma ESRRG 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0015
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
1275 Estrogen sulfotransferase SULT1E1 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
444 Alcohol dehydrogenase 1B ADH1B 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0012
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0012
3917 Methylenetetrahydrofolate reductase MTHFR 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0011
3937 Fatty-acid amide hydrolase FAAH 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
1630 Integrin beta-2 ITGB2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
4217 Telomerase reverse transcriptase TERT 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
517 Alcohol dehydrogenase 1C ADH1C 0.001
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
820 Glycine receptor subunit alpha-2 GLRA2 0.001
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
268 Adenosine A2b receptor ADORA2B 0.001
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.001
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6163 Copper-transporting ATPase 2 ATP7B 0.0009
6165 Copper-transporting ATPase 1 ATP7A 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3830 Calreticulin CALR 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
572 Integrin alpha-L ITGAL 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
1867 Major prion protein PRNP 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1039 Histone deacetylase 9 HDAC9 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
822 Aldose reductase AKR1B1 0.0007
2207 Rhodopsin RHO 0.0007
6218 Pannexin-1 PANX1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
2021 Thrombomodulin THBD 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
798 Osteocalcin BGLAP 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
↑