DT-Web

DB01361 - Troleandomycin


Identification
Name Troleandomycin
Accession Number DB01361
Type small molecule
Description A macrolide antibiotic that is similar to erythromycin.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 813.9684
Groups approved
Monoisotopic Weight 813.451070479
Pharmacology
Indication For the treatment of Pneumococcal pneumonia due to susceptible strains and group A beta-hemolytic streptococcal infections of the upper respiratory tract.
Mechanism of action Troleandomycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the "P" or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the "A" or acceptor site to the "P" or donor site is prevented, and subsequent protein synthesis is inhibited.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Aminophylline The macrolide, troleandomycin, may increase the effect and toxicity of theophylline derivative, aminophylline.
Aprepitant This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Astemizole Increased risk of cardiotoxicity and arrhythmias
Carbamazepine The macrolide, troleandomycin, may increase the effect of carbamazepine.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Citalopram Possible serotoninergic syndrome with this combination
Colchicine Severe colchicine toxicity can occur
Cyclosporine The macrolide, troleandomycin, may increase the effect of cyclosporine.
Dihydroergotamine Possible ergotism and severe ischemia with this combination
Eletriptan The macrolide, troleandomycin, may increase the effect and toxicity of eletriptan.
Eplerenone The macrolide, troleandomycin, may increase the effect and toxicity of eplerenone.
Ergotamine Possible ergotism and severe ischemia with this combination
Erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Fluoxetine Possible serotoninergic syndrome with this combination
Methysergide Possible ergotism and severe ischemia with this combination
Oxtriphylline The macrolide, troleandomycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Pimozide Increased risk of cardiotoxicity and arrhythmias
Tacrolimus The macrolide antibiotic, Troleandomycin, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Troleandomycin therapy is initiated, discontinued or altered.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Theophylline The macrolide, troleandomycin, may increase the effect and toxicity of theophylline.
Food Interactions Not Available

Targets


50S ribosomal protein L32
Name 50S ribosomal protein L32
Gene Name rpmF
Pharmacological action yes
Actions inhibitor
References
  • Scharre KA, Eckels DD, Gershwin ME: Depression of colony formation by human thymus-derived lymphocytes with rifampin and other antimicrobial agents. J Infect Dis. 1981 Jun;143(6):832-5. - Pubmed
DTHybrid score 0.3695
50S ribosomal protein L4
Name 50S ribosomal protein L4
Gene Name rplD
Pharmacological action yes
Actions inhibitor
References
  • Scharre KA, Eckels DD, Gershwin ME: Depression of colony formation by human thymus-derived lymphocytes with rifampin and other antimicrobial agents. J Infect Dis. 1981 Jun;143(6):832-5. - Pubmed
DTHybrid score 0.0122

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5655
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions Not Available
References
  • Klees TM, Sheffels P, Dale O, Kharasch ED: Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug Metab Dispos. 2005 Mar;33(3):303-11. Epub 2004 Nov 22. - Pubmed
DTHybrid score 0.4881
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions Not Available
References
  • Ono S, Hatanaka T, Hotta H, Satoh T, Gonzalez FJ, Tsutsui M: Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica. 1996 Jul;26(7):681-93. - Pubmed
DTHybrid score 0.6288
Cytochrome P450 3A43
Name Cytochrome P450 3A43
Gene Name CYP3A43
Actions inducer
References
  • Ledirac N, de Sousa G, Fontaine F, Agouridas C, Gugenheim J, Lorenzon G, Rahmani R: Effects of macrolide antibiotics on CYP3A expression in human and rat hepatocytes: interspecies differences in response to troleandomycin. Drug Metab Dispos. 2000 Dec;28(12):1391-3. - Pubmed
DTHybrid score 0.2838
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4201
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3292
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5009
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8047

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
  • Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed
  • Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed
DTHybrid score 0.5137

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.367
4200 Cytochrome P450 1A2 CYP1A2 0.295
6107 Cytochrome P450 3A7 CYP3A7 0.2917
6030 Cytochrome P450 2B6 CYP2B6 0.2301
6013 Cytochrome P450 2E1 CYP2E1 0.1969
6024 Cytochrome P450 1A1 CYP1A1 0.1381
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1184
20 Prostaglandin G/H synthase 1 PTGS1 0.1157
587 Serum albumin ALB 0.1144
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.081
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0767
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0744
1729 Solute carrier family 22 member 6 SLC22A6 0.069
862 Multidrug resistance-associated protein 1 ABCC1 0.0643
1181 Alpha-1-acid glycoprotein 1 ORM1 0.063
3811 Cytochrome P450 19A1 CYP19A1 0.0621
492 Histamine H1 receptor HRH1 0.0596
1898 Cytochrome P450 1B1 CYP1B1 0.0592
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0589
824 Sodium-dependent serotonin transporter SLC6A4 0.0586
290 Prostaglandin G/H synthase 2 PTGS2 0.0564
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0511
776 Bile salt export pump ABCB11 0.0502
6145 Solute carrier family 22 member 1 SLC22A1 0.0499
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0486
468 Cytochrome P450 4A11 CYP4A11 0.048
6143 Solute carrier family 22 member 7 SLC22A7 0.0473
6144 Solute carrier family 22 member 2 SLC22A2 0.0456
871 Glucocorticoid receptor NR3C1 0.0454
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0436
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0416
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0415
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0414
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0413
136 Estrogen receptor ESR1 0.0389
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0388
502 5-hydroxytryptamine 2A receptor HTR2A 0.0384
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0379
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0378
831 D(2) dopamine receptor DRD2 0.0375
6142 Solute carrier family 22 member 8 SLC22A8 0.0374
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.037
556 Alpha-1A adrenergic receptor ADRA1A 0.0367
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0366
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0364
118 Organic cation/carnitine transporter 2 SLC22A5 0.0362
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0359
847 Mu-type opioid receptor OPRM1 0.0356
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0349
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0343
320 5-hydroxytryptamine 1A receptor HTR1A 0.0339
766 Beta-2 adrenergic receptor ADRB2 0.0334
51 Muscarinic acetylcholine receptor M3 CHRM3 0.033
3941 Amine oxidase [flavin-containing] A MAOA 0.0329
2164 Multidrug resistance-associated protein 4 ABCC4 0.0327
260 Cytochrome P450 51 ERG11 0.0326
761 Cytochrome P450 51 ERG11 0.0326
3163 Cytochrome P450 51 cyp51 0.0326
731 HIV-1 protease HIV-1 protease 0.0323
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0321
467 Delta-type opioid receptor OPRD1 0.0319
617 Muscarinic acetylcholine receptor M2 CHRM2 0.031
208 DNA-directed RNA polymerase beta' chain rpoC 0.0296
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0296
6147 Solute carrier family 22 member 3 SLC22A3 0.0279
696 Kappa-type opioid receptor OPRK1 0.0277
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0275
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0275
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0268
713 Sodium-dependent dopamine transporter SLC6A3 0.026
3939 Amine oxidase [flavin-containing] B MAOB 0.0258
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0258
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0258
590 5-hydroxytryptamine 2C receptor HTR2C 0.0256
6182 Cytochrome P450 2J2 CYP2J2 0.0255
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0253
341 5-hydroxytryptamine 3 receptor HTR3A 0.0253
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0252
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0252
23 D(1A) dopamine receptor DRD1 0.0252
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0248
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0246
632 Alpha-1B adrenergic receptor ADRA1B 0.0245
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0238
318 Alpha-2A adrenergic receptor ADRA2A 0.0236
6014 Cytochrome P450 2A13 CYP2A13 0.0234
380 Cytochrome P450 17A1 CYP17A1 0.0234
465 Calmodulin CALM1 0.0233
844 Epidermal growth factor receptor EGFR 0.0233
146 Androgen receptor AR 0.0231
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.023
817 DNA topoisomerase 2-alpha TOP2A 0.0225
122 P2Y purinoceptor 12 P2RY12 0.0221
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.022
833 Organic cation/carnitine transporter 1 SLC22A4 0.0219
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0219
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0218
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0217
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0217
193 Beta-1 adrenergic receptor ADRB1 0.0212
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.021
6102 Arylamine N-acetyltransferase 2 NAT2 0.021
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0208
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0208
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0208
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0208
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0208
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0206
6136 Multidrug resistance-associated protein 5 ABCC5 0.0205
3923 Cholinesterase BCHE 0.0204
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0203
614 Progesterone receptor PGR 0.0203
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0202
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0202
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0202
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0201
891 Dihydropteroate synthase folP 0.0201
5359 Dihydropteroate synthase folP 0.0201
7175 Dihydropteroate synthase sulI 0.0201
6141 Sodium/bile acid cotransporter SLC10A1 0.0196
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0196
1024 Solute carrier family 22 member 11 SLC22A11 0.0196
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.019
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0189
70 Type-1 angiotensin II receptor AGTR1 0.0184
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0184
811 Translocator protein TSPO 0.0181
789 Alpha-1D adrenergic receptor ADRA1D 0.018
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.018
6148 Multidrug resistance-associated protein 7 ABCC10 0.018
756 Sex hormone-binding globulin SHBG 0.0179
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0178
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0176
885 5-hydroxytryptamine 1B receptor HTR1B 0.0172
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0171
232 Corticosteroid-binding globulin SERPINA6 0.017
638 D(3) dopamine receptor DRD3 0.0169
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0167
4604 Liver carboxylesterase 1 CES1 0.0167
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0165
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0164
84 Nuclear receptor 0B1 NR0B1 0.0163
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0161
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0161
6137 Multidrug resistance-associated protein 6 ABCC6 0.016
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0159
725 5-hydroxytryptamine 1D receptor HTR1D 0.0157
85 Growth hormone receptor GHR 0.0156
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0156
504 Mast/stem cell growth factor receptor KIT 0.0154
737 Mineralocorticoid receptor NR3C2 0.0153
1483 Membrane copper amine oxidase AOC3 0.0151
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.015
4773 Deoxycytidine kinase DCK 0.0148
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0146
869 Estrogen receptor beta ESR2 0.0145
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0144
3913 Glutamic acid decarboxylase GAD65 0.0144
407 Vascular endothelial growth factor receptor 2 KDR 0.0139
777 Tumor necrosis factor TNF 0.0137
629 Alpha-2B adrenergic receptor ADRA2B 0.0136
124 Histamine H2 receptor HRH2 0.0135
29 Tubulin beta-1 chain TUBB1 0.0134
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0131
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0131
4237 50S ribosomal protein L22 rplV 0.0131
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0131
26 Vascular endothelial growth factor receptor 3 FLT4 0.0128
469 Annexin A1 ANXA1 0.0126
952 Dipeptidyl peptidase 4 DPP4 0.0125
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0125
4120 NADPH--cytochrome P450 reductase POR 0.0124
32 Vascular endothelial growth factor receptor 1 FLT1 0.0122
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0122
4238 50S ribosomal protein L4 rplD 0.0122
5578 50S ribosomal protein L4 rplD 0.0122
6219 50S ribosomal protein L4 rplD 0.0122
436 5-hydroxytryptamine 2B receptor HTR2B 0.0121
275 Arachidonate 5-lipoxygenase ALOX5 0.0121
161 Tubulin beta chain TUBB 0.0121
312 Tubulin beta chain TUB2 0.0121
4148 Serine/threonine-protein kinase mTOR MTOR 0.0121
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.012
3904 Alanine aminotransferase 2 GPT2 0.012
735 Alanine aminotransferase 1 GPT 0.012
1192 Sulfotransferase 1A1 SULT1A1 0.0118
378 Alpha-2C adrenergic receptor ADRA2C 0.0118
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0117
373 Transthyretin TTR 0.0116
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0116
716 5-hydroxytryptamine 7 receptor HTR7 0.0115
818 50S ribosomal protein L10 rplJ 0.0114
284 DNA-directed RNA polymerase beta chain rpoB 0.0113
5773 DNA-directed RNA polymerase beta chain rpoB 0.0113
1010 Cytochrome P450 51A1 CYP51A1 0.0112
228 Beta platelet-derived growth factor receptor PDGFRB 0.0112
705 Glutamate receptor 1 GRIA1 0.0111
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0111
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0109
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0107
738 Monocarboxylate transporter 1 SLC16A1 0.0107
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0106
6220 Aryl hydrocarbon receptor AHR 0.0106
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0105
427 Substance-P receptor TACR1 0.0105
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0105
1757 Myeloperoxidase MPO 0.0105
88 Retinoic acid receptor RXR-beta RXRB 0.0104
432 D(4) dopamine receptor DRD4 0.0103
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0103
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0102
921 Glutamate receptor 2 GRIA2 0.0101
94 5-hydroxytryptamine 4 receptor HTR4 0.01
365 Dihydrofolate reductase DHFR 0.01
2381 Dihydrofolate reductase DFR1 0.01
2833 Dihydrofolate reductase Not Available 0.01
2931 Dihydrofolate reductase folA 0.01
3544 Dihydrofolate reductase folA 0.01
3682 Dihydrofolate reductase folA 0.01
6642 Dihydrofolate reductase folA 0.01
6756 Dihydrofolate reductase dfrA 0.01
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0099
2539 Tubulin alpha-1 chain TUBA4A 0.0098
477 DNA topoisomerase 4 subunit A parC 0.0097
886 DNA topoisomerase 4 subunit A parC 0.0097
6226 DNA topoisomerase 4 subunit A parC 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
3808 Dihydropteroate synthase 2 folP2 0.0097
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0097
3601 Dihydropteroate synthase 1 folP1 0.0097
3807 Dihydropteroate synthase 1 folP1 0.0097
68 Cannabinoid receptor 1 CNR1 0.0097
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0097
5300 Antigen peptide transporter 1 TAP1 0.0096
404 DNA gyrase subunit A gyrA 0.0096
6224 DNA gyrase subunit A gyrA 0.0096
49 Endothelin B receptor EDNRB 0.0096
295 Carbonic anhydrase 1 CA1 0.0096
1656 CYP2B protein CYP2B 0.0095
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0094
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0091
528 5-hydroxytryptamine 1E receptor HTR1E 0.0091
780 Retinoic acid receptor RXR-gamma RXRG 0.0091
6085 Fatty acid-binding protein, intestinal FABP2 0.009
239 Coagulation factor X F10 0.009
578 Endothelin-1 receptor EDNRA 0.009
592 Carbonic anhydrase 4 CA4 0.009
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0088
3810 Catechol O-methyltransferase COMT 0.0087
24 Thymidylate synthase TMP1 0.0087
359 Thymidylate synthase TYMS 0.0087
2626 Thymidylate synthase thyA 0.0087
2729 Thymidylate synthase thyA 0.0087
5352 Thymidylate synthase THYA 0.0087
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0087
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0086
482 Glycine receptor subunit alpha-1 GLRA1 0.0085
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0085
518 Peroxidase/catalase T katG 0.0085
474 Acetylcholinesterase ACHE 0.0084
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0084
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
3932 Glutathione S-transferase A2 GSTA2 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0083
6432 Transporter snf 0.0083
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0082
6020 Aldehyde oxidase AOX1 0.0081
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.008
7 Nitric oxide synthase, inducible NOS2 0.0079
3426 Glutamine synthetase glnA 0.0079
3987 Glutamine synthetase GLUL 0.0079
54 Prothrombin F2 0.0079
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0078
162 Retinoic acid receptor gamma-1 RARG 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
719 Retinoic acid receptor responder protein 1 RARRES1 0.0078
770 Retinoic acid-induced protein 3 GPRC5A 0.0078
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0077
4203 Histamine N-methyltransferase HNMT 0.0077
2230 Catalase CAT 0.0076
3249 Catalase katA 0.0076
3625 Catalase katA 0.0076
4539 Catalase katA 0.0076
4941 Catalase katB 0.0076
1541 Metalloproteinase mmp20 0.0074
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0074
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0074
823 Fibroblast growth factor receptor 2 FGFR2 0.0073
106 Cannabinoid receptor 2 CNR2 0.0072
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0072
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
571 Melatonin receptor type 1A MTNR1A 0.007
362 Melatonin receptor type 1B MTNR1B 0.007
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.007
1353 DNA topoisomerase 1 TOP1 0.007
3552 DNA topoisomerase 1 topA 0.007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.007
1852 Microtubule-associated protein 2 MAP2 0.007
3809 Estrogen-related receptor gamma ESRRG 0.007
244 Angiotensin-converting enzyme ACE 0.0068
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0068
569 Retinal dehydrogenase 2 ALDH1A2 0.0068
165 FL cytokine receptor FLT3 0.0068
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0067
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0067
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0067
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
357 Carbonic anhydrase 2 CA2 0.0067
768 FK506-binding protein 1A FKBP1A 0.0067
6138 Multidrug resistance protein 3 ABCB4 0.0067
319 Opioid receptor, sigma 1 OPRS1 0.0066
1039 Histone deacetylase 9 HDAC9 0.0065
3947 Xanthine dehydrogenase/oxidase XDH 0.0065
1256 5-hydroxytryptamine 6 receptor HTR6 0.0064
814 Ryanodine receptor 1 RYR1 0.0064
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0064
537 ATP synthase delta chain, mitochondrial ATP5D 0.0064
1275 Estrogen sulfotransferase SULT1E1 0.0064
611 Retinal dehydrogenase 1 ALDH1A1 0.0063
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1618 High affinity nerve growth factor receptor NTRK1 0.0063
133 Dihydropterate synthase sulI 0.0063
131 Synaptic vesicular amine transporter SLC18A2 0.0062
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0062
251 Alcohol dehydrogenase 1A ADH1A 0.0062
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0062
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0062
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0062
1050 Bile salt sulfotransferase SULT2A1 0.0062
183 Vascular endothelial growth factor A VEGFA 0.0061
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0061
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.006
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.006
273 Apoptosis regulator Bcl-2 BCL2 0.006
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
1196 Complement decay-accelerating factor CD55 0.006
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0059
444 Alcohol dehydrogenase 1B ADH1B 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
3937 Fatty-acid amide hydrolase FAAH 0.0058
563 Thyroid peroxidase TPO 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
153 Dopamine beta-hydroxylase DBH 0.0057
1178 Adenosine A2a receptor ADORA2A 0.0057
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0057
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0057
2449 Tubulin alpha-3 chain TUBA1A 0.0056
4311 tRNA TRDMT1 0.0056
4325 tRNA trmD 0.0056
4328 tRNA trmD 0.0056
856 Vitamin D3 receptor VDR 0.0055
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0055
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
4122 Histone deacetylase 2 HDAC2 0.0054
1629 Transcription factor AP-1 JUN 0.0054
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0054
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0054
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0054
163 D(1B) dopamine receptor DRD5 0.0054
4217 Telomerase reverse transcriptase TERT 0.0053
3086 Plasmepsin-2 Not Available 0.0053
2112 Toll-like receptor 9 TLR9 0.0053
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0053
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
4103 Proteasome subunit beta type 2 PSMB2 0.0052
4102 Proteasome subunit beta type 5 PSMB5 0.0052
4101 Proteasome subunit beta type 1 PSMB1 0.0052
511 5-hydroxytryptamine 1F receptor HTR1F 0.0052
2808 Chloramphenicol acetyltransferase 3 cat3 0.0052
6126 Carbonic anhydrase 7 CA7 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0051
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0051
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0051
2981 Phospholipase A2, membrane associated PLA2G2A 0.0051
1360 Sphingomyelin phosphodiesterase SMPD1 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
517 Alcohol dehydrogenase 1C ADH1C 0.005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0049
16 Adenosine A1 receptor ADORA1 0.0049
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
2417 Chloramphenicol acetyltransferase cat 0.0047
3278 Chloramphenicol acetyltransferase cat 0.0047
5787 Angiopoietin-1 receptor TEK 0.0047
2810 Dr hemagglutinin structural subunit draA 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0046
3856 Fibroblast growth factor receptor 3 FGFR3 0.0046
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0046
1630 Integrin beta-2 ITGB2 0.0046
1648 Elastin ELN 0.0046
976 Platelet glycoprotein IX GP9 0.0046
904 Glutathione S-transferase P GSTP1 0.0046
527 Prostacyclin receptor PTGIR 0.0045
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0044
130 Prostacyclin synthase PTGIS 0.0044
5934 Cytochrome P450 26A1 CYP26A1 0.0044
2298 Cytochrome P450-cam camC 0.0043
581 Cytochrome P450 2R1 CYP2R1 0.0043
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0043
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0042
6043 Putative G-protein coupled receptor 44 GPR44 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
174 Sigma 1-type opioid receptor SIGMAR1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6149 Solute carrier family 22 member 10 SLC22A10 0.004
6824 Tyrosine-protein kinase Lyn LYN 0.004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.004
634 Squalene monooxygenase SQLE 0.004
7196 Squalene monooxygenase ERG1 0.004
459 Retinoic acid receptor RXR-alpha RXRA 0.004
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.004
1517 Beta-3 adrenergic receptor ADRB3 0.0039
3639 Thymidine phosphorylase deoA 0.0039
3936 Thymidine phosphorylase TYMP 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0038
936 Ephrin type-A receptor 2 EPHA2 0.0038
33 Cystine/glutamate transporter SLC7A11 0.0038
6044 Serum paraoxonase/lactonase 3 PON3 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0037
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0037
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0037
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0037
4192 DNA topoisomerase 2-beta TOP2B 0.0037
3917 Methylenetetrahydrofolate reductase MTHFR 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
164 Histamine H4 receptor HRH4 0.0036
4226 Uridine phosphorylase 2 UPP2 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0035
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0035
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0035
572 Integrin alpha-L ITGAL 0.0035
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0035
939 50S ribosomal protein L3 rplC 0.0035
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
6146 High affinity copper uptake protein 1 SLC31A1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0034
5880 Thrombopoietin receptor MPL 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0033
4225 Uridine phosphorylase 1 UPP1 0.0032
6048 Troponin C, skeletal muscle TNNC2 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
605 Fumarate reductase flavoprotein subunit frdA 0.0032
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0032
3673 Fumarate reductase flavoprotein subunit fccA 0.0032
4912 Fumarate reductase flavoprotein subunit ifcA 0.0032
6549 Fumarate reductase flavoprotein subunit frdA 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0032
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0032
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0032
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0032
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0032
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
1992 Vitamin D-binding protein GC 0.0031
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0031
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0031
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
413 Amidophosphoribosyltransferase PPAT 0.003
2515 Amidophosphoribosyltransferase purF 0.003
3714 Amidophosphoribosyltransferase purF 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
2216 Fibroblast growth factor receptor 4 FGFR4 0.0029
267 Plasminogen activator inhibitor 1 SERPINE1 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0028
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
2207 Rhodopsin RHO 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
5798 Mitogen-activated protein kinase 11 MAPK11 0.0027
908 Glutathione S-transferase theta-1 GSTT1 0.0027
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0027
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
1864 RET proto-oncogene RET 0.0027
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0026
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0026
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6221 Steroid hormone receptor ERR1 ESRRA 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
291 Nitric-oxide synthase, endothelial NOS3 0.0024
6218 Pannexin-1 PANX1 0.0024
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
65 Matrix metalloproteinase-9 Not Available 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0023
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0022
2232 Interleukin-5 IL5 0.0022
1268 Neuropeptide S receptor NPSR1 0.0021
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0021
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0021
3957 Adenosine deaminase ADA 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.002
1063 Signal transducer and activator of transcription 5B STAT5B 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6459 Glycodelin PAEP 0.002
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
400 Coagulation factor IX F9 0.002
5461 Coagulation factor IX F9 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0019
484 Tyrosine-protein kinase ABL2 ABL2 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
1253 Interferon gamma IFNG 0.0018
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0018
604 Vitamin K-dependent protein Z PROZ 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
751 Potassium channel subfamily K member 6 KCNK6 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
3221 Cytochrome c4 cc4 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
1374 Natriuretic peptides B NPPB 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
3830 Calreticulin CALR 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
4948 Cytochrome c-553 Not Available 0.0017
4923 Cytochrome c3 DvMF_2499 0.0017
4945 Cytochrome c3 Not Available 0.0017
4949 Cytochrome c3 DVU_3171 0.0017
4968 Cytochrome c3 cytc3 0.0017
4997 Cytochrome c3 SO_2727 0.0017
5219 Cytochrome c3 cyd 0.0017
4902 Nine-heme cytochrome c Ddes_2038 0.0017
3189 High-molecular-weight cytochrome c hmcA 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
820 Glycine receptor subunit alpha-2 GLRA2 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
702 UMP-CMP kinase CMPK1 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
4954 Soluble cytochrome b558 Not Available 0.0014
4934 Cytochrome c-551 nirM 0.0014
5218 Cytochrome c-551 nirM 0.0014
4905 Cytochrome c2 Not Available 0.0014
4939 Cytochrome c2 cycA 0.0014
4964 Cytochrome c2 cycA 0.0014
4979 Cytochrome c2 cycA 0.0014
6673 Cytochrome c2 cycA 0.0014
4915 Cytochrome c-550 psbV 0.0014
4959 Cytochrome c-550 psbV 0.0014
5216 Cytochrome c-550 psbV 0.0014
4925 Cytochrome c-type protein SHP shp 0.0014
4947 Bacterial hemoglobin vhb 0.0014
4998 Hemoglobin-like protein yjbI yjbI 0.0014
4975 Cytochrome c-556 RPA3973 0.0014
4943 Cytochrome c6 petJ 0.0014
4916 Cyanoglobin glbN 0.0014
4984 Neuroglobin NGB 0.0014
4936 Cytochrome c2 iso-2 Not Available 0.0014
4994 Hemoglobin-like protein HbO glbO 0.0014
4907 Cytochrome c-L moxG 0.0014
6865 Cytochrome c-L moxG 0.0014
4909 CooA protein cooA 0.0014
644 Heme oxygenase 2 HMOX2 0.0014
4982 Heme oxygenase 2 pbsA2 0.0014
4942 Diheme cytochrome c napB napB 0.0014
4935 Cytochrome c-554 cycA1 0.0014
4904 Cytochrome c family protein GSU1996 0.0014
4910 Cytoglobin CYGB 0.0014
4961 Hemophore HasA hasA 0.0014
4971 Nonaheme cytochrome c hmcA 0.0014
4981 Iron-starvation protein PigA pigA 0.0014
5000 HemO hemO 0.0014
4989 Cytochrome c551 peroxidase ccp 0.0014
5222 Cytochrome c551 peroxidase ccpA 0.0014
4976 Apocytochrome f petA 0.0014
6407 Apocytochrome f petA 0.0014
4999 Cytochrome P450 165B3 CYP165B3 0.0014
4764 Cytochrome P450 165C4 CYP165C4 0.0014
4960 Putative cytochrome P450-family protein SCO7417 0.0014
4931 Cytochrome P450 167A1 CYP167A1 0.0014
4926 Heme-based aerotactic transducer hemAT hemAT 0.0014
4937 Cytochrome oxidase subunit II rcoxA 0.0014
4993 Hydroxylamine oxidoreductase hao1 0.0014
4903 Methyl-accepting chemotaxis protein Tar4 0.0014
4922 Cytochrome c, putative SO_4144 0.0014
4972 P450cin cinA 0.0014
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0014
3093 Catalase HPII katE 0.0014
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0014
4952 Catalase/peroxidase katA 0.0014
1341 Histamine H3 receptor HRH3 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
4386 Hemoglobin-like protein HbN glbN 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
896 Glutathione S-transferase Mu 1 GSTM1 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
798 Osteocalcin BGLAP 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
369 Coagulation factor VII F7 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1507 Cytochrome c CYCS 0.0011
4920 Peroxidase/catalase katG 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
2119 Cytochrome b5 CYB5A 0.0011
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.001
4990 PpcA ppcA 0.001
4988 Sulfite oxidase, mitochondrial SUOX 0.001
3375 Acidic cytochrome c3 Not Available 0.001
4385 Cytochrome c' Not Available 0.001
4967 Cytochrome c' cycA 0.001
5038 Cytochrome c' Not Available 0.001
5223 Cytochrome c' cycP 0.001
2915 Sensor protein fixL fixL 0.001
4944 Sensor protein fixL fixL 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
3570 Cytochrome P450 152A1 cypC 0.001
4992 Cytochrome c peroxidase Not Available 0.001
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
4813 Heme oxygenase hmuO 0.001
5769 Heme oxygenase Not Available 0.001
4289 Cytochrome P450 TT_P0059 0.001
6262 Cytochrome P450 staP 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
3670 Soluble cytochrome b562 precursor cybC 0.0009
3411 Cytochrome P450 121 cyp121 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
3291 Cytochrome c-552 cycA 0.0009
4927 Cytochrome c-552 nrfA 0.0009
4938 Cytochrome c-552 cycA 0.0009
4953 Cytochrome c-552 nrfA 0.0009
5217 Cytochrome c-552 cycM 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
2617 Nitric oxide synthase oxygenase nos 0.0009
2701 Nitric oxide synthase oxygenase nos 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
3102 Flavohemoprotein hmp 0.0009
4969 Flavohemoprotein hmp 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2972 6-deoxyerythronolide B hydroxylase eryF 0.0008
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6163 Copper-transporting ATPase 2 ATP7B 0.0008
6165 Copper-transporting ATPase 1 ATP7A 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
4608 Putative cytochrome P450 SCO1207 0.0008
4963 Putative cytochrome P450 SCO2884 0.0008
6254 Putative cytochrome P450 SCO6998 0.0008
1025 Aquaporin-1 AQP1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
358 Cystathionine beta-synthase CBS 0.0007
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
693 Hemoglobin subunit beta HBB 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
125 DNA polymerase beta POLB 0.0007
6268 Hydroxyacid oxidase 1 HAO1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5818 Folate receptor alpha FOLR1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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