DT-Web: DB00091

Identification

Name

Cyclosporine

Accession Number

DB00091 (BIOD00003, BTD00003)

Type

small molecule

Description

A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. Cyclosporine is produced as a metabolite by the fungus species Cordyceps militaris. (From Martindale, The Extra Pharmacopoeia, 30th ed).

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

1202.6112

Groups

approved

Monoisotopic Weight

1201.841368071

Pharmacology

Indication

For treatment of transplant (kidney, liver, and heart) rejection, rheumatoid arthritis, severe psoriasis.

Mechanism of action

Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and interleukin release. In ophthalmic applications, the precise mechanism of action is not known. Cyclosporine emulsion is thought to act as a partial immunomodulator in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca.

Absorption

The absorption of cyclosporine from the gastrointestinal tract is incomplete and variable. The extent of absorption is dependent on the individual patient, the patient population, and the formulation. The absolute bioavailability of cyclosproine administered as Sandimmune(R) is dependent on the patient population, estimated to be less than 10% in liver transplant patients and as great as 89% in some renal transplant patients. Compared to an intravenous infusion, the absolute bioavailability of the oral solution is approximately 30% based upon the results in 2 patients. The cyclosporine capsules and oral solution are bioequivalent. The time of peak blood concentrations (Tmax) following oral administration of cyclosporine [modified] ranged from 1.5 - 2.0 hours.

Protein binding

In the plasma, approximately 90% is bound to proteins, primarily lipoproteins. In blood, the distribution is concentration dependent. Approximately 33% to 47% is in plasma, 4% to 9% in lymphocytes, 5% to 12% in granulocytes, and 41% to 58% in erythrocytes.

Biotransformation

Hepatic, extensively metabolized by the cytochrome P450 3A enzyme system in the liver. It is also metabolized in the gastrointestinal tract and kidney to a lesser degree. The metabolites are significantly less potent than the parent compound. The major metabolites (M1, M9, and M4N) result from oxidation at the 1-beta, 9-gamma, and 4-N-demethylated positions, respectively.

Route of elimination

Elimination is primarily biliary with only 6% of the dose (parent drug and metabolites) excreted in the urine. Only 0.1% of the dose is excreted in the urine as unchanged drug.

Toxicity

The oral LD₅₀ is 2329 mg/kg in mice, 1480 mg/kg in rats, and > 1000 mg/kg in rabbits. The I.V. LD₅₀ is 148 mg/kg in mice, 104 mg/kg in rats, and 46 mg/kg in rabbits.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acetazolamide	Acetazolamide may increase the effect and toxicity of cyclosporine.
Allopurinol	Allopurinol increases the effect and toxicity of cyclosporine
Amiodarone	Amiodarone may increase the therapeutic and adverse effects of cyclosporine.
Amobarbital	The barbiturate, amobarbital, increases the effect of cyclosporine.
Amphotericin B	Monitor for nephrotoxicity
Amprenavir	The protease inhibitor, amprenavir, may increase the effect of cyclosporine.
Aprobarbital	The barbiturate, aprobarbital, increases the effect of cyclosporine.
Atazanavir	Atazanavir may increase the therapeutic and adverse effects of cyclosporine.
Atorvastatin	Possible myopathy and rhabdomyolysis
Azithromycin	The macrolide, azithromycin, may increase the effect of cyclosporine.
Bezafibrate	Cyclosporine may enhance the nephrotoxic effect of fibric acid derivatives like bezafibrate. Fibric acid derivatives may decrease the serum concentration of cyclosporine. Extra monitoring of renal function and cyclosporine concentrations will likely be required. Adjustment of cyclosporine dose may be necessary.
Bosentan	Cyclosporine may increase the effect and toxicity of bosentan.
Bupropion	Bupropion may decrease the therapeutic effect of cyclosporine.
Butabarbital	The barbiturate, butabarbital, increases the effect of cyclosporine.
Butalbital	The barbiturate, butalbital, increases the effect of cyclosporine.
Butethal	The barbiturate, butethal, increases the effect of cyclosporine.
Carbamazepine	Carbamazepine may decrease the therapeutic effect of cyclosporine.
Carvedilol	Carvedilol may increase the therapeutic and adverse effects of cyclosporine.
Caspofungin	Cyclosporine increases the effect and toxicity of caspofungin
Cerivastatin	Possible myopathy and rhabdomyolysis
Chloramphenicol	Chloramphenicol may increase the effect of cyclosporine.
Chloroquine	Chloroquine may increase the therapeutic and adverse effects of cyclosporine.
Cilastatin	Imipenem increases the effect and toxicity of cyclosporine
Ciprofloxacin	Ciprofloxacin may increase the effect and toxicity of cyclosporine.
Clarithromycin	The macrolide, clarithromycin, may increase the effect of cyclosporine.
Clindamycin	Clindamycin may decrease the therapeutic effect of cyclosporine.
Colchicine	Increased toxicity of both drugs
Danazol	The androgen, danazol, may increase the effect and toxicity of cyclosporine.
Diclofenac	Monitor for nephrotoxicity
Digoxin	Cyclosporine may increase the effect of digoxin.
Dihydroquinidine barbiturate	The barbiturate, dihydroquinidine barbiturate, increases the effect of cyclosporine.
Diltiazem	Diltiazem may increase the effect and toxicity of cyclosporine.
Dronedarone	Cyclosporine is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Efavirenz	Efavirenz decreases the levels of cyclosporine
Erythromycin	The macrolide, erythromycin, may increase the effect of cyclosporine.
Ethinyl Estradiol	The contraceptive increases the effect and toxicity of cyclosporine
Ethotoin	The hydantoin decreases the effect of cyclosporine
Etodolac	Monitor for nephrotoxicity
Etoposide	Cyclosporine may increase the therapeutic and adverse effects of etoposide.
Ezetimibe	Cyclosporine may increase the therapeutic and adverse effects of ezetimibe.
Fenoprofen	Monitor for nephrotoxicity
Fidaxomicin	Cyclosporin is an inhibitor of p-glycoprotein and concomitant therapy will result in a increase in Cmax and AUC of fidaxomicin and its metabolite.
Fluconazole	Fluconazole may increase the therapeutic and adverse effects of the cyclosporine.
Fluoxetine	The antidepressant increases the effect and toxicity of cyclosporine
Flurbiprofen	Monitor for nephrotoxicity
Fluvastatin	Possible myopathy and rhabdomyolysis
Fosamprenavir	The protease inhibitor, fosamprenavir, may increase the effect of cyclosporine.
Foscarnet	Monitor for nephrotoxicity
Fosphenytoin	The hydantoin decreases the effect of cyclosporine
Glimepiride	The sulfonylurea, glimepiride, may increase the effect of cyclosporine.
Glipizide	The sulfonylurea, glipizide, may increase the effect of cyclosporine.
Glyburide	The sulfonylurea, glibenclamide, may increase the effect of cyclosporine.
Griseofulvin	Griseofulvin decreases the effect of cyclosporine
Heptabarbital	The barbiturate, heptabarbital, increases the effect of cyclosporine.
Hexobarbital	The barbiturate, hexobarbital, increases the effect of cyclosporine.
Ibuprofen	Monitor for nephrotoxicity
Imatinib	Imatinib increases the effect and toxicity of cyclosporine
Imipenem	Imipenem increases the effect and toxicity of cyclosporine
Indinavir	The protease inhibitor, indinavir, may increase the effect of cyclosporine.
Indomethacin	Monitor for nephrotoxicity
Itraconazole	Itraconazole may increase the effect of cyclosporine.
Josamycin	The macrolide, josamycin, may increase the effect of cyclosporine.
Ketoconazole	Ketoconazole may increase the effect of cyclosporine.
Ketoprofen	The NSAID, ketoprofen, may increase the serum concentration of cyclosporine. Ketoprofen may also increase the nephrotoxicity of cyclosporine.
Lovastatin	Possible myopathy and rhabdomyolysis
Meclofenamic acid	Monitor for nephrotoxicity
Mefenamic acid	Monitor for nephrotoxicity
Melphalan	Melphalan increases toxicity of cyclosporine
Mephenytoin	The hydantoin decreases the effect of cyclosporine
Mestranol	The contraceptive increases the effect and toxicity of cyclosporine
Methohexital	The barbiturate, methohexital, increases the effect of cyclosporine.
Methotrexate	Cyclosporine may increase the effect and toxicity of methotrexate.
Methylphenidate	Methylphenidate increases the effect and toxicity of cyclosporine
Methylphenobarbital	The barbiturate, methylphenobarbital, increases the effect of cyclosporine.
Metoclopramide	Metoclopramide increases serum levels of cyclosporine
Modafinil	Modafinil decreases the effect of cyclosporine
Muromonab	Muromonab increases the levels of cyclosporine
Nabumetone	Monitor for nephrotoxicity
Nafcillin	Nafcillin alters serum levels of cyclosporine
Naproxen	Monitor for nephrotoxicity
Nefazodone	The antidepressant increases the effect and toxicity of cyclosporine
Nelfinavir	The protease inhibitor, nelfinavir, may increase the effect of cyclosporine.
Nicardipine	Nicardipine increases the effect and toxicity of cyclosporine
Nifedipine	Increased risk of gingivitis
Norfloxacin	Norfloxacin may increase the effect and toxicity of cyclosporine.
Octreotide	Octreotide decreases the effect of cyclosporine
Omeprazole	Omeprazole increases the effect and toxicity of cyclosporine
Orlistat	Orlistat decreases the effect of cyclosporine
Oxaprozin	Monitor for nephrotoxicity
Oxcarbazepine	Oxcarbazepine decreases the effect of cyclosporine
Pentobarbital	The barbiturate, pentobarbital, increases the effect of cyclosporine.
Phenobarbital	The barbiturate, phenobarbital, may decrease the therapeutic effect of cyclosporine by increasing its metabolism.
Phenytoin	The hydantoin decreases the effect of cyclosporine
Piroxicam	Monitor for nephrotoxicity
Pitavastatin	Cyclosporine decreases metabolism of pitavastatin thus increasing serum concentration. Avoid concomitant drug therapy.
Posaconazole	Increased level of cyclosporine
Pravastatin	Possible myopathy and rhabdomyolysis
Primidone	The barbiturate, primidone, increases the effect of cyclosporine.
Probucol	Probucol decreases the effect of cyclosporine
Propafenone	Propafenone increases the effect and toxicity of cyclosporine
Pyrazinamide	Pyrazinamide decreases the effect of cyclosporine
Quinidine barbiturate	The barbiturate, quinidine barbiturate, increases the effect of cyclosporine.
Quinupristin	Synercid increases the effect of cyclosporine
Repaglinide	Cyclosporine may increase the therapeutic and adverse effects of repaglinide.
Rifabutin	The rifamycin decreases the effect of cyclosporine
Rifampin	The rifamycin decreases the effect of cyclosporine
Rilonacept	results in increased immunosuppressive effects; increases the risk of infection.
Ritonavir	The protease inhibitor, ritonavir, may increase the effect of cyclosporine.
Rosuvastatin	Cyclosporine may increase the serum concentration of rosuvastatin. Limit rosuvastatin dosing to 5 mg/day and monitor for changes in the therapeutic and adverse effects of rosuvastatin if cyclosporine is initiated, discontinued or dose changed.
Roxithromycin	The macrolide, roxithromycin, may increase the effect of cyclosporine.
Saquinavir	The protease inhibitor, saquinavir, may increase the effect of cyclosporine.
Secobarbital	The barbiturate, secobarbital, increases the effect of cyclosporine.
Sevelamer	Sevelamer decreases the effect of cyclosporine
Sibutramine	Sibutramine increases the effect and toxicity of cyclosporine
Simvastatin	Possible myopathy and rhabdomyolysis
Sirolimus	Increases the effect and toxicity of sirolimus
St. John's Wort	St. John's Wort decreases the effect of cyclosporine
Sulfadiazine	The sulfonamide decreases the effect of cyclosporine
Sulfamethazine	The sulfonamide decreases the effect of cyclosporine
Sulfamethoxazole	The sulfonamide decreases the effect of cyclosporine
Sulfasalazine	The sulfonamide decreases the effect of cyclosporine
Sulfinpyrazone	Sulfinpyrazone decreases the effect of cyclosporine
Sulindac	The NSAID, sulindac, may increase the nephrotoxic effect of cyclosporine. Sulindac may increase the serum concentration of cyclosporine. Consider alternate therapy or monitor for increased cyclosporine levels and nephrotoxicity during concomitant therapy.
Tacrolimus	Additive renal impairment may occur during concomitant therapy with cyclosporine. Combination therapy should be avoided.
Talbutal	The sulfonamide decreases the effect of cyclosporine
Tamsulosin	Cyclosporine, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Cyclosporine is initiated, discontinued, or dose changed.
Telaprevir	Telaprevir increases levels by affecting CYP3A4 metabolism. Must monitor levels closely with concomitant therapy.
Telithromycin	Telithromycin may reduce clearance of cyclosporine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of cyclosporine if telithromycin is initiated, discontinued or dose changed.
Tenoxicam	Monitor for nephrotoxicity
Terbinafine	Terbinafine may decrease the plasma concentration and therapeutic effect of cyclosporine.
Testolactone	The androgen, Testolactone, may increase the hepatotoxicity of Cyclosporine. Testolatone may also elevate serum concentrations of Cyclosporine. Consider alternate therapy or monitor for signs of renal and hepatic toxicity.
Testosterone	The androgen, Testosterone, may increase the hepatotoxicity of Cyclosporine. Testosterone may also elevate serum concentrations of Cyclosporine. Consider alternate therapy or monitor for signs of renal and hepatic toxicity.
Testosterone Propionate	The androgen, Testosterone, may increase the hepatotoxicity of Cyclosporine. Testosterone may also elevate serum concentrations of Cyclosporine. Consider alternate therapy or monitor for signs of renal and hepatic toxicity.
Thiopental	Thiopental may increase the metabolism and clearance of Cyclosporine. Monitor for changes in the therapeutic/adverse effects of Cyclosporine if Thiopental is initiated, discontinued or dose changed.
Tiaprofenic acid	Tiaprofenic acid may increase the nephrotoxicity and/or the serum concentration of cyclosporine. Consider altnerate therapy or monitor for increased cyclosporine concentrations and nephrotoxicity during concomitant therapy.
Ticlopidine	Ticlopidine decreases the effect of cyclosporine
Tipranavir	Tipranavir may affect the efficacy/toxicity of Cyclosporine.
Tobramycin	Increased risk of nephrotoxicity
Tofacitinib	Cyclosporin (and other strong immunosuppressants), when used in combination with tofacitinib, may increase the risk of added immunosuppression and infection. It is recommended to avoid concurrent therapy.
Tolmetin	Tolmetin may increase the serum concentration of cyclosporine and/or increase the nephrotoxicity of cyclosporine. Consider alternate therapy or monitor for increased cyclosporine serum concentration and nephrotoxicity during concomitant therapy.
Tolterodine	Cyclosporine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Topotecan	The p-glycoprotein inhibitor, Cyclosporine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tramadol	Cyclosporine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trandolapril	The ACE inhibitor, Trandolapril, may increase the nephrotoxicity of Cyclosporine.
transdermal testosterone gel	The androgen, Testosterone, may increase the hepatotoxicity of Cyclosporine. Testosterone may also elevate serum concentrations of Cyclosporine. Consider alternate therapy or monitor for signs of renal and hepatic toxicity.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Trazodone	The CYP3A4 inhibitor, Cyclosporine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Cyclosporine is initiated, discontinued or dose changed.
Troglitazone	Troglitazone decreases the effect of the immunosuppressant
Troleandomycin	The macrolide, troleandomycin, may increase the effect of cyclosporine.
Ursodeoxycholic acid	Ursodiol increases the levels of cyclosporine
Verapamil	Verapamil may increase the serum concentration of cyclosporine by inhibiting CYP3A4-mediated metabolism of cyclosporine. Monitor for changes in the therapeutic/adverse effects of cyclosporine if verapamil is initiated, discontinued or dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of cyclosporine by decreasing its metabolism. Consider reducing the dose of cyclosporine. Monitor cyclosporine serum concentrations and therapeutic and toxic effects if initiating, discontinuing or adjusting voriconazole therapy.

Food Interactions

Avoid taking with grapefruit or grapefruit juice as grapefruit can significantly increase serum levels of this product.
Red wine may reduce cyclosporine levels due to increased metabolism, therefore it appears prudent to avoid red wine (white wine does not appear to affect cyclosporine metabolism).
When taken with a meal, AUC and Cmax of cyclosporine modified decreased.
Avoid salt substitutes containing potassium.

Calcium signal-modulating cyclophilin ligand
Name	Calcium signal-modulating cyclophilin ligand
Gene Name	CAMLG
Pharmacological action	yes
Actions	binder
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Bernasconi R, Solda T, Galli C, Pertel T, Luban J, Molinari M: Cyclosporine a-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation. PLoS One. 2010 Sep 28;5(9). pii: e13008. - Pubmed Yamashita H, Ito T, Kato H, Asai S, Tanaka H, Nagai H, Inagaki N: Comparison of the efficacy of tacrolimus and cyclosporine A in a murine model of dinitrofluorobenzene-induced atopic dermatitis. Eur J Pharmacol. 2010 Oct 25;645(1-3):171-6. Epub 2010 Aug 3. - Pubmed Galat A, Bua J: Molecular aspects of cyclophilins mediating therapeutic actions of their ligands. Cell Mol Life Sci. 2010 Oct;67(20):3467-88. Epub 2010 Jul 4. - Pubmed Lee J, Kim SS: Current implications of cyclophilins in human cancers. J Exp Clin Cancer Res. 2010 Jul 19;29:97. - Pubmed
DTHybrid score	0.2242
Calcineurin subunit B isoform 2
Name	Calcineurin subunit B isoform 2
Gene Name	PPP3R2
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Yamashita H, Ito T, Kato H, Asai S, Tanaka H, Nagai H, Inagaki N: Comparison of the efficacy of tacrolimus and cyclosporine A in a murine model of dinitrofluorobenzene-induced atopic dermatitis. Eur J Pharmacol. 2010 Oct 25;645(1-3):171-6. Epub 2010 Aug 3. - Pubmed
DTHybrid score	0.2242
Peptidyl-prolyl cis-trans isomerase A
Name	Peptidyl-prolyl cis-trans isomerase A
Gene Name	PPIA
Pharmacological action	unknown
Actions	Not Available
References	Keckesova Z, Ylinen LM, Towers GJ: Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity. J Virol. 2006 May;80(10):4683-90. - Pubmed Patwardhan AM, Jeske NA, Price TJ, Gamper N, Akopian AN, Hargreaves KM: The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11393-8. Epub 2006 Jul 18. - Pubmed Redell JB, Zhao J, Dash PK: Acutely increased cyclophilin a expression after brain injury: a role in blood-brain barrier function and tissue preservation. J Neurosci Res. 2007 Jul;85(9):1980-8. - Pubmed Schaller T, Ylinen LM, Webb BL, Singh S, Towers GJ: Fusion of cyclophilin A to Fv1 enables cyclosporine-sensitive restriction of human and feline immunodeficiency viruses. J Virol. 2007 Sep;81(18):10055-63. Epub 2007 Jul 3. - Pubmed Lee J, Kim SS: Current implications of cyclophilins in human cancers. J Exp Clin Cancer Res. 2010 Jul 19;29:97. - Pubmed Stegmann CM, Luhrmann R, Wahl MC: The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein. PLoS One. 2010 Apr 2;5(4):e10013. - Pubmed
DTHybrid score	1.1318

Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate,inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5242
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate,inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6612
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score	1.0746
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6451
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.622
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7565
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6844

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Romiti N, Tramonti G, Chieli E: Influence of different chemicals on MDR-1 P-glycoprotein expression and activity in the HK-2 proximal tubular cell line. Toxicol Appl Pharmacol. 2002 Sep 1;183(2):83-91. - Pubmed Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. - Pubmed Tiberghien F, Kurome T, Takesako K, Didier A, Wenandy T, Loor F: Aureobasidins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC-transporter. J Med Chem. 2000 Jun 29;43(13):2547-56. - Pubmed Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed Leonessa F, Kim JH, Ghiorghis A, Kulawiec RJ, Hammer C, Talebian A, Clarke R: C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump. J Med Chem. 2002 Jan 17;45(2):390-8. - Pubmed Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol. 2002 May;61(5):964-73. - Pubmed Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. - Pubmed Kumar S, Kwei GY, Poon GK, Iliff SA, Wang Y, Chen Q, Franklin RB, Didolkar V, Wang RW, Yamazaki M, Chiu SH, Lin JH, Pearson PG, Baillie TA: Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein. J Pharmacol Exp Ther. 2003 Mar;304(3):1161-71. - Pubmed Horie K, Tang F, Borchardt RT: Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res. 2003 Feb;20(2):161-8. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Atkinson DE, Greenwood SL, Sibley CP, Glazier JD, Fairbairn LJ: Role of MDR1 and MRP1 in trophoblast cells, elucidated using retroviral gene transfer. Am J Physiol Cell Physiol. 2003 Sep;285(3):C584-91. Epub 2003 Apr 30. - Pubmed Hamada A, Miyano H, Watanabe H, Saito H: Interaction of imatinib mesilate with human P-glycoprotein. J Pharmacol Exp Ther. 2003 Nov;307(2):824-8. Epub 2003 Sep 15. - Pubmed Corea G, Fattorusso E, Lanzotti V, Taglialatela-Scafati O, Appendino G, Ballero M, Simon PN, Dumontet C, Di Pietro A: Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L. Bioorg Med Chem. 2003 Nov 17;11(23):5221-7. - Pubmed Rao US, Scarborough GA: Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein. Mol Pharmacol. 1994 Apr;45(4):773-6. - Pubmed Pouliot JF, L'Heureux F, Liu Z, Prichard RK, Georges E: Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem Pharmacol. 1997 Jan 10;53(1):17-25. - Pubmed Kuhnel JM, Perrot JY, Faussat AM, Marie JP, Schwaller MA: Functional assay of multidrug resistant cells using JC-1, a carbocyanine fluorescent probe. Leukemia. 1997 Jul;11(7):1147-55. - Pubmed Ito T, Yano I, Tanaka K, Inui KI: Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997 Aug;282(2):955-60. - Pubmed Kim AE, Dintaman JM, Waddell DS, Silverman JA: Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. J Pharmacol Exp Ther. 1998 Sep;286(3):1439-45. - Pubmed Kusunoki N, Takara K, Tanigawara Y, Yamauchi A, Ueda K, Komada F, Ku Y, Kuroda Y, Saitoh Y, Okumura K: Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein. Jpn J Cancer Res. 1998 Nov;89(11):1220-8. - Pubmed Golstein PE, Boom A, van Geffel J, Jacobs P, Masereel B, Beauwens R: P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Arch. 1999 Apr;437(5):652-60. - Pubmed Wigler PW: PSC833, cyclosporin A, and dexniguldipine effects on cellular calcein retention and inhibition of the multidrug resistance pump in human leukemic lymphoblasts. Biochem Biophys Res Commun. 1999 Apr 13;257(2):410-3. - Pubmed Hochman JH, Chiba M, Nishime J, Yamazaki M, Lin JH: Influence of P-glycoprotein on the transport and metabolism of indinavir in Caco-2 cells expressing cytochrome P-450 3A4. J Pharmacol Exp Ther. 2000 Jan;292(1):310-8. - Pubmed Asakura E, Nakayama H, Sugie M, Zhao YL, Nadai M, Kitaichi K, Shimizu A, Miyoshi M, Takagi K, Takagi K, Hasegawa T: Azithromycin reverses anticancer drug resistance and modifies hepatobiliary excretion of doxorubicin in rats. Eur J Pharmacol. 2004 Jan 26;484(2-3):333-9. - Pubmed D'Emanuele A, Jevprasesphant R, Penny J, Attwood D: The use of a dendrimer-propranolol prodrug to bypass efflux transporters and enhance oral bioavailability. J Control Release. 2004 Mar 24;95(3):447-53. - Pubmed Honda Y, Ushigome F, Koyabu N, Morimoto S, Shoyama Y, Uchiumi T, Kuwano M, Ohtani H, Sawada Y: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. Br J Pharmacol. 2004 Dec;143(7):856-64. Epub 2004 Oct 25. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed Yasuda K, Lan LB, Sanglard D, Furuya K, Schuetz JD, Schuetz EG: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. J Pharmacol Exp Ther. 2002 Oct;303(1):323-32. - Pubmed Kugawa F, Suzuki T, Miyata M, Tomono K, Tamanoi F: Construction of a model cell line for the assay of MDR1 (multi drug resistance gene-1) substrates/inhibitors using HeLa cells. Pharmazie. 2009 May;64(5):296-300. - Pubmed Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. Epub 2009 Mar 25. - Pubmed Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS: Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther. 2001 Nov;299(2):620-8. - Pubmed Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed Seeballuck F, Ashford MB, O'Driscoll CM: The effects of pluronics block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells. Pharm Res. 2003 Jul;20(7):1085-92. - Pubmed Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T: Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem. 1993 Mar 25;268(9):6077-80. - Pubmed Fricker G, Drewe J, Huwyler J, Gutmann H, Beglinger C: Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation. Br J Pharmacol. 1996 Aug;118(7):1841-7. - Pubmed Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB: Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther. 1997 Sep;62(3):248-60. - Pubmed Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ: Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr;16(4):478-85. - Pubmed Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. - Pubmed
DTHybrid score	0.8672
Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inhibitor
References	Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed
DTHybrid score	0.3137
Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	inhibitor
References	Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. - Pubmed Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed Noe J, Hagenbuch B, Meier PJ, St-Pierre MV: Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology. 2001 May;33(5):1223-31. - Pubmed Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed Stieger B, Fattinger K, Madon J, Kullak-Ublick GA, Meier PJ: Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. Gastroenterology. 2000 Feb;118(2):422-30. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.4724
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inhibitor
References	Pec MK, Aguirre A, Fernandez JJ, Souto ML, Dorta JF, Villar J: Dehydrothyrsiferol does not modulate multidrug resistance-associated protein 1 resistance: a functional screening system for MRP1 substrates. Int J Mol Med. 2002 Nov;10(5):605-8. - Pubmed Leier I, Jedlitschky G, Buchholz U, Cole SP, Deeley RG, Keppler D: The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. J Biol Chem. 1994 Nov 11;269(45):27807-10. - Pubmed
DTHybrid score	0.4598
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
DTHybrid score	0.5431
Ileal sodium/bile acid cotransporter
Name	Ileal sodium/bile acid cotransporter
Gene Name	SLC10A2
Actions	inhibitor
References	Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, Dawson PA: Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69. - Pubmed
DTHybrid score	0.4129
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions	inhibitor
References	Schroeder A, Eckhardt U, Stieger B, Tynes R, Schteingart CD, Hofmann AF, Meier PJ, Hagenbuch B: Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol. 1998 Feb;274(2 Pt 1):G370-5. - Pubmed
DTHybrid score	0.4023
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Sweet DH, Wolff NA, Pritchard JB: Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem. 1997 Nov 28;272(48):30088-95. - Pubmed
DTHybrid score	0.476
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	inhibitor
References	Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed
DTHybrid score	0.2625
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inhibitor
References	Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem Biophys Res Commun. 2003 Oct 10;310(1):222-7. - Pubmed Kamisako T, Leier I, Cui Y, Konig J, Buchholz U, Hummel-Eisenbeiss J, Keppler D: Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology. 1999 Aug;30(2):485-90. - Pubmed Chen ZS, Kawabe T, Ono M, Aoki S, Sumizawa T, Furukawa T, Uchiumi T, Wada M, Kuwano M, Akiyama SI: Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol Pharmacol. 1999 Dec;56(6):1219-28. - Pubmed Horikawa M, Kato Y, Tyson CA, Sugiyama Y: The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab Pharmacokinet. 2002;17(1):23-33. - Pubmed
DTHybrid score	0.5584
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	Ozvegy C, Litman T, Szakacs G, Nagy Z, Bates S, Varadi A, Sarkadi B: Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells. Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7. - Pubmed
DTHybrid score	0.52
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. - Pubmed Shitara Y, Itoh T, Sato H, Li AP, Sugiyama Y: Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A. J Pharmacol Exp Ther. 2003 Feb;304(2):610-6. - Pubmed Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A: Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. J Pharm Pharmacol. 2003 Jul;55(7):1013-20. - Pubmed Fehrenbach T, Cui Y, Faulstich H, Keppler D: Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):415-20. Epub 2003 Oct 3. - Pubmed
DTHybrid score	0.4757

Id	Partner name	Gene Name	Score
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	1.1318
4200	Cytochrome P450 1A2	CYP1A2	0.4219
6030	Cytochrome P450 2B6	CYP2B6	0.2869
6013	Cytochrome P450 2E1	CYP2E1	0.2488
587	Serum albumin	ALB	0.2453
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.2396
6142	Solute carrier family 22 member 8	SLC22A8	0.2352
2164	Multidrug resistance-associated protein 4	ABCC4	0.2127
6024	Cytochrome P450 1A1	CYP1A1	0.2058
6145	Solute carrier family 22 member 1	SLC22A1	0.1652
20	Prostaglandin G/H synthase 1	PTGS1	0.161
5718	Cytochrome P450 2A6	CYP2A6	0.1566
6143	Solute carrier family 22 member 7	SLC22A7	0.1442
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1349
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.1304
1024	Solute carrier family 22 member 11	SLC22A11	0.1262
1898	Cytochrome P450 1B1	CYP1B1	0.125
6144	Solute carrier family 22 member 2	SLC22A2	0.1217
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1153
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.1057
290	Prostaglandin G/H synthase 2	PTGS2	0.105
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.1046
6106	Cytochrome P450 2C18	CYP2C18	0.1029
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.1012
118	Organic cation/carnitine transporter 2	SLC22A5	0.0981
492	Histamine H1 receptor	HRH1	0.0929
6137	Multidrug resistance-associated protein 6	ABCC6	0.0929
817	DNA topoisomerase 2-alpha	TOP2A	0.0907
136	Estrogen receptor	ESR1	0.0872
824	Sodium-dependent serotonin transporter	SLC6A4	0.0814
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0801
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0778
3811	Cytochrome P450 19A1	CYP19A1	0.0771
731	HIV-1 protease	HIV-1 protease	0.0764
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0741
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0736
6147	Solute carrier family 22 member 3	SLC22A3	0.0731
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0724
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0723
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0722
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0722
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0708
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0676
3587	Gastrotropin	FABP6	0.0652
738	Monocarboxylate transporter 1	SLC16A1	0.065
6136	Multidrug resistance-associated protein 5	ABCC5	0.0633
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0623
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0618
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0616
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0614
6031	Cytochrome P450 3A43	CYP3A43	0.0603
831	D(2) dopamine receptor	DRD2	0.06
871	Glucocorticoid receptor	NR3C1	0.0598
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0586
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0581
847	Mu-type opioid receptor	OPRM1	0.058
33	Cystine/glutamate transporter	SLC7A11	0.0577
833	Organic cation/carnitine transporter 1	SLC22A4	0.0575
556	Alpha-1A adrenergic receptor	ADRA1A	0.0572
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0543
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0525
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0524
70	Type-1 angiotensin II receptor	AGTR1	0.0509
468	Cytochrome P450 4A11	CYP4A11	0.0501
6167	Organic solute transporter subunit beta	OSTB	0.05
6166	Organic solute transporter subunit alpha	OSTA	0.05
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0499
338	DNA polymerase	UL30	0.0498
379	DNA polymerase	UL54	0.0498
697	DNA polymerase	ORF28	0.0498
2482	DNA polymerase	43	0.0498
4104	DNA polymerase	BALF5	0.0498
4604	Liver carboxylesterase 1	CES1	0.0491
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0483
24	Thymidylate synthase	TMP1	0.0462
359	Thymidylate synthase	TYMS	0.0462
2626	Thymidylate synthase	thyA	0.0462
2729	Thymidylate synthase	thyA	0.0462
5352	Thymidylate synthase	THYA	0.0462
766	Beta-2 adrenergic receptor	ADRB2	0.0458
467	Delta-type opioid receptor	OPRD1	0.0456
161	Tubulin beta chain	TUBB	0.0452
312	Tubulin beta chain	TUB2	0.0452
29	Tubulin beta-1 chain	TUBB1	0.0442
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.044
696	Kappa-type opioid receptor	OPRK1	0.0425
260	Cytochrome P450 51	ERG11	0.0424
761	Cytochrome P450 51	ERG11	0.0424
3163	Cytochrome P450 51	cyp51	0.0424
614	Progesterone receptor	PGR	0.0415
404	DNA gyrase subunit A	gyrA	0.0415
6224	DNA gyrase subunit A	gyrA	0.0415
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0411
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0411
713	Sodium-dependent dopamine transporter	SLC6A3	0.0406
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0401
4773	Deoxycytidine kinase	DCK	0.0401
3941	Amine oxidase [flavin-containing] A	MAOA	0.0397
4120	NADPH--cytochrome P450 reductase	POR	0.0397
380	Cytochrome P450 17A1	CYP17A1	0.0396
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0396
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0393
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0392
617	Muscarinic acetylcholine receptor M2	CHRM2	0.039
632	Alpha-1B adrenergic receptor	ADRA1B	0.0388
2539	Tubulin alpha-1 chain	TUBA4A	0.0388
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0386
737	Mineralocorticoid receptor	NR3C2	0.0383
844	Epidermal growth factor receptor	EGFR	0.038
193	Beta-1 adrenergic receptor	ADRB1	0.0378
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0376
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0369
23	D(1A) dopamine receptor	DRD1	0.0367
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0367
318	Alpha-2A adrenergic receptor	ADRA2A	0.0366
504	Mast/stem cell growth factor receptor	KIT	0.036
373	Transthyretin	TTR	0.036
146	Androgen receptor	AR	0.0359
904	Glutathione S-transferase P	GSTP1	0.0359
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0354
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0351
756	Sex hormone-binding globulin	SHBG	0.0347
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0345
6182	Cytochrome P450 2J2	CYP2J2	0.0345
477	DNA topoisomerase 4 subunit A	parC	0.0344
886	DNA topoisomerase 4 subunit A	parC	0.0344
6226	DNA topoisomerase 4 subunit A	parC	0.0344
273	Apoptosis regulator Bcl-2	BCL2	0.0339
5923	Microtubule-associated protein tau	MAPT	0.033
5924	Microtubule-associated protein 4	MAP4	0.033
1852	Microtubule-associated protein 2	MAP2	0.033
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0322
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0322
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0322
3923	Cholinesterase	BCHE	0.0319
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0319
3947	Xanthine dehydrogenase/oxidase	XDH	0.0318
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0318
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0312
869	Estrogen receptor beta	ESR2	0.0312
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0308
5626	Nucleoside diphosphate kinase B	NME2	0.0305
407	Vascular endothelial growth factor receptor 2	KDR	0.03
638	D(3) dopamine receptor	DRD3	0.03
758	Thyroid hormone receptor alpha	THRA	0.0299
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0297
26	Vascular endothelial growth factor receptor 3	FLT4	0.0296
6149	Solute carrier family 22 member 10	SLC22A10	0.0295
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0289
465	Calmodulin	CALM1	0.0287
4192	DNA topoisomerase 2-beta	TOP2B	0.0287
32	Vascular endothelial growth factor receptor 1	FLT1	0.0283
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0282
594	Thyroxine-binding globulin	SERPINA7	0.028
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0279
6085	Fatty acid-binding protein, intestinal	FABP2	0.0278
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0274
908	Glutathione S-transferase theta-1	GSTT1	0.0269
346	Thyroid hormone receptor beta-1	THRB	0.0268
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0266
1353	DNA topoisomerase 1	TOP1	0.0266
3552	DNA topoisomerase 1	topA	0.0266
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0265
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0263
2808	Chloramphenicol acetyltransferase 3	cat3	0.0262
1650	Heme carrier protein 1	SLC46A1	0.0257
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0256
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0254
275	Arachidonate 5-lipoxygenase	ALOX5	0.0253
3917	Methylenetetrahydrofolate reductase	MTHFR	0.025
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0249
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0246
5294	Nucleoside diphosphate kinase A	NME1	0.0246
3809	Estrogen-related receptor gamma	ESRRG	0.0245
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0243
509	Thymidine kinase	TK	0.0241
570	Thymidine kinase	TK	0.0241
2559	Thymidine kinase	TK	0.0241
3430	Thymidine kinase	tdk	0.0241
3518	Thymidine kinase	TK	0.0241
5301	Thymidine kinase	tdk	0.0241
5771	Thymidine kinase	ORF36	0.0241
7009	Thymidine kinase	ORF36	0.0241
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.024
592	Carbonic anhydrase 4	CA4	0.0238
3611	Cytidine deaminase	cdd	0.0237
3707	Cytidine deaminase	cdd	0.0237
4211	Cytidine deaminase	CDA	0.0237
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0237
295	Carbonic anhydrase 1	CA1	0.0235
789	Alpha-1D adrenergic receptor	ADRA1D	0.0232
723	Cytosolic phospholipase A2	PLA2G4A	0.023
122	P2Y purinoceptor 12	P2RY12	0.0228
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0227
293	Gamma-glutamyl hydrolase	GGH	0.0225
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0224
952	Dipeptidyl peptidase 4	DPP4	0.0223
6220	Aryl hydrocarbon receptor	AHR	0.0223
2391	Ferrochelatase	hemH	0.0223
6502	Ferrochelatase	DKFZp686P18130	0.0223
1591	Ferrochelatase, mitochondrial	FECH	0.0223
1757	Myeloperoxidase	MPO	0.0221
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0221
244	Angiotensin-converting enzyme	ACE	0.022
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.022
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0219
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0219
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0219
702	UMP-CMP kinase	CMPK1	0.0218
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0218
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0218
3939	Amine oxidase [flavin-containing] B	MAOB	0.0216
117	Sterol O-acyltransferase 1	SOAT1	0.0216
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0214
558	Solute carrier family 12 member 1	SLC12A1	0.0214
6151	Monocarboxylate transporter 10	SLC16A10	0.0214
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0211
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.021
49	Endothelin B receptor	EDNRB	0.0209
629	Alpha-2B adrenergic receptor	ADRA2B	0.0208
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0207
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0206
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0206
232	Corticosteroid-binding globulin	SERPINA6	0.0206
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0203
683	Potassium transporter	GK0582	0.0203
357	Carbonic anhydrase 2	CA2	0.0202
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0199
887	DNA gyrase subunit B	gyrB	0.0198
4150	DNA gyrase subunit B	gyrB	0.0198
6225	DNA gyrase subunit B	gyrB	0.0198
578	Endothelin-1 receptor	EDNRA	0.0197
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0195
365	Dihydrofolate reductase	DHFR	0.0194
2381	Dihydrofolate reductase	DFR1	0.0194
2833	Dihydrofolate reductase	Not Available	0.0194
2931	Dihydrofolate reductase	folA	0.0194
3544	Dihydrofolate reductase	folA	0.0194
3682	Dihydrofolate reductase	folA	0.0194
6642	Dihydrofolate reductase	folA	0.0194
6756	Dihydrofolate reductase	dfrA	0.0194
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0194
811	Translocator protein	TSPO	0.0194
378	Alpha-2C adrenergic receptor	ADRA2C	0.0191
124	Histamine H2 receptor	HRH2	0.0191
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0191
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0191
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0191
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0191
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0191
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.019
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.019
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.019
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.019
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.019
6559	Cytochrome c oxidase subunit 2	ctaC	0.019
6669	Cytochrome c oxidase subunit 2	ctaC	0.019
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.019
371	Cytochrome c oxidase subunit 1	MT-CO1	0.019
6558	Cytochrome c oxidase subunit 1	ctaD	0.019
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.019
165	FL cytokine receptor	FLT3	0.0189
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0188
469	Annexin A1	ANXA1	0.0188
3810	Catechol O-methyltransferase	COMT	0.0188
891	Dihydropteroate synthase	folP	0.0187
5359	Dihydropteroate synthase	folP	0.0187
7175	Dihydropteroate synthase	sulI	0.0187
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0187
432	D(4) dopamine receptor	DRD4	0.0186
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0185
633	Penicillin-binding proteins 1A/1B	pbpA	0.0185
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0182
3270	Elongation factor G	fusA	0.0181
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.018
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0179
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0177
6020	Aldehyde oxidase	AOX1	0.0177
2540	Choloylglycine hydrolase	cbh	0.0176
1010	Cytochrome P450 51A1	CYP51A1	0.0176
777	Tumor necrosis factor	TNF	0.0175
131	Synaptic vesicular amine transporter	SLC18A2	0.0174
1629	Transcription factor AP-1	JUN	0.0171
890	Niemann-Pick C1-like protein 1	NPC1L1	0.017
3639	Thymidine phosphorylase	deoA	0.017
3936	Thymidine phosphorylase	TYMP	0.017
6014	Cytochrome P450 2A13	CYP2A13	0.0168
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0167
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0167
6043	Putative G-protein coupled receptor 44	GPR44	0.0167
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0167
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0166
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0164
6501	Fatty acid-binding protein, liver	FABP1	0.0163
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0163
5787	Angiopoietin-1 receptor	TEK	0.0162
4237	50S ribosomal protein L22	rplV	0.0162
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0161
4085	Peptidyl-prolyl cis-trans isomerase C	PPIC	0.0161
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0161
1192	Sulfotransferase 1A1	SULT1A1	0.0159
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0158
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0157
4083	Peptidyl-prolyl cis-trans isomerase H	PPIH	0.0157
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0156
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0156
4238	50S ribosomal protein L4	rplD	0.0155
5578	50S ribosomal protein L4	rplD	0.0155
6173	50S ribosomal protein L4	rplD	0.0155
6219	50S ribosomal protein L4	rplD	0.0155
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0155
4086	Peptidyl-prolyl cis-trans isomerase G	PPIG	0.0154
6168	Solute carrier family 22 member 16	SLC22A16	0.0154
4090	Chromosome 14 open reading frame 149	C14orf149	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
4082	Proline oxidase, mitochondrial	PRODH	0.0154
4087	Pyrroline 5-carboxylate reductase isoform	P5CR2	0.0154
4088	Probable prolyl-tRNA synthetase, mitochondrial	PARS2	0.0154
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0154
797	Sodium-dependent proline transporter	SLC6A7	0.0154
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.0153
1760	Aminopeptidase N	ANPEP	0.0152
6843	Aminopeptidase N	pepN	0.0152
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0152
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0152
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0152
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0152
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0152
6218	Pannexin-1	PANX1	0.0151
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0149
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0149
2554	Peptidyl-prolyl cis-trans isomerase, mitochondrial	PPIF	0.0149
6146	High affinity copper uptake protein 1	SLC31A1	0.0148
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0147
489	Monocarboxylate transporter 2	SLC16A7	0.0146
3856	Fibroblast growth factor receptor 3	FGFR3	0.0146
6102	Arylamine N-acetyltransferase 2	NAT2	0.0146
199	Monocarboxylate transporter 8	SLC16A2	0.0146
7	Nitric oxide synthase, inducible	NOS2	0.0146
716	5-hydroxytryptamine 7 receptor	HTR7	0.0146
5818	Folate receptor alpha	FOLR1	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
284	DNA-directed RNA polymerase beta chain	rpoB	0.0145
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0145
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0143
94	5-hydroxytryptamine 4 receptor	HTR4	0.0142
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0142
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0142
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0142
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0142
6126	Carbonic anhydrase 7	CA7	0.0141
183	Vascular endothelial growth factor A	VEGFA	0.0141
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.014
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0139
1050	Bile salt sulfotransferase	SULT2A1	0.0137
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0137
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0137
474	Acetylcholinesterase	ACHE	0.0137
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0137
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0136
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0136
2449	Tubulin alpha-3 chain	TUBA1A	0.0135
818	50S ribosomal protein L10	rplJ	0.0135
1630	Integrin beta-2	ITGB2	0.0135
6500	Phospholipase A2	PLA2G1B	0.0135
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0134
427	Substance-P receptor	TACR1	0.0133
461	Glycine receptor subunit alpha-3	GLRA3	0.0132
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
517	Alcohol dehydrogenase 1C	ADH1C	0.0131
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.013
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.013
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.013
3307	Acriflavine resistance protein B	acrB	0.013
53	Solute carrier family 12 member 5	SLC12A5	0.013
663	Solute carrier family 12 member 4	SLC12A4	0.013
1830	5'-nucleotidase	NT5E	0.0129
768	FK506-binding protein 1A	FKBP1A	0.0128
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
896	Glutathione S-transferase Mu 1	GSTM1	0.0128
6042	Prostaglandin reductase 2	PTGR2	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
84	Nuclear receptor 0B1	NR0B1	0.0127
1656	CYP2B protein	CYP2B	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
992	Protein tyrosine kinase 2 beta	PTK2B	0.0126
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0125
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0124
823	Fibroblast growth factor receptor 2	FGFR2	0.0124
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0123
1313	Lactoylglutathione lyase	GLO1	0.0123
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0123
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0123
125	DNA polymerase beta	POLB	0.0123
3874	Proline synthetase co-transcribed bacterial homolog protein	PROSC	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
6210	Tubulin delta chain	TUBD1	0.0122
6212	Tubulin gamma-1 chain	TUBG1	0.0122
6211	Tubulin epsilon chain	TUBE1	0.0122
6163	Copper-transporting ATPase 2	ATP7B	0.0121
6165	Copper-transporting ATPase 1	ATP7A	0.0121
310	Solute carrier family 12 member 2	SLC12A2	0.012
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.012
6171	Solute carrier family 28 member 3	SLC28A3	0.012
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.012
4122	Histone deacetylase 2	HDAC2	0.0119
3932	Glutathione S-transferase A2	GSTA2	0.0119
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0118
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0117
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
163	D(1B) dopamine receptor	DRD5	0.0114
5880	Thrombopoietin receptor	MPL	0.0114
299	Folate receptor beta	FOLR2	0.0114
718	Folate receptor gamma	FOLR3	0.0114
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0114
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0113
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0111
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.011
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.011
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.011
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.011
1256	5-hydroxytryptamine 6 receptor	HTR6	0.011
6044	Serum paraoxonase/lactonase 3	PON3	0.0109
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0108
2443	Azurin	azu	0.0108
921	Glutamate receptor 2	GRIA2	0.0108
645	Penicillin-binding protein 1A	mrcA	0.0107
5805	Penicillin-binding protein 1A	ponA	0.0107
6185	Penicillin-binding protein 1A	mrcA	0.0107
6799	Penicillin-binding protein 1A	pbpA	0.0107
6138	Multidrug resistance protein 3	ABCB4	0.0104
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0102
572	Integrin alpha-L	ITGAL	0.0101
1196	Complement decay-accelerating factor	CD55	0.0101
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0101
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.01
2320	Thymidine kinase, cytosolic	TK1	0.01
140	30S ribosomal protein S9	rpsI	0.01
6719	30S ribosomal protein S9	rpsI	0.01
6725	30S ribosomal protein S9	rpsI	0.01
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0099
1517	Beta-3 adrenergic receptor	ADRB3	0.0099
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0099
1618	High affinity nerve growth factor receptor	NTRK1	0.0099
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0099
239	Coagulation factor X	F10	0.0098
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
2112	Toll-like receptor 9	TLR9	0.0097
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0096
4203	Histamine N-methyltransferase	HNMT	0.0096
751	Potassium channel subfamily K member 6	KCNK6	0.0096
5300	Antigen peptide transporter 1	TAP1	0.0096
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0096
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
68	Cannabinoid receptor 1	CNR1	0.0094
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0092
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
976	Platelet glycoprotein IX	GP9	0.0089
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
172	Potassium channel subfamily K member 1	KCNK1	0.0088
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0088
2216	Fibroblast growth factor receptor 4	FGFR4	0.0087
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0087
291	Nitric-oxide synthase, endothelial	NOS3	0.0087
319	Opioid receptor, sigma 1	OPRS1	0.0087
76	Nitric-oxide synthase, brain	NOS1	0.0086
1178	Adenosine A2a receptor	ADORA2A	0.0085
6824	Tyrosine-protein kinase Lyn	LYN	0.0084
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0084
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0084
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
267	Plasminogen activator inhibitor 1	SERPINE1	0.0083
814	Ryanodine receptor 1	RYR1	0.0083
5934	Cytochrome P450 26A1	CYP26A1	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
6033	High affinity interleukin-8 receptor A	CXCR1	0.0081
22	30S ribosomal protein S4	rpsD	0.0081
6714	30S ribosomal protein S4	rpsD	0.0081
2417	Chloramphenicol acetyltransferase	cat	0.008
3278	Chloramphenicol acetyltransferase	cat	0.008
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.008
6837	Serine/threonine-protein kinase 17B	STK17B	0.008
1525	Heparin-binding growth factor 2	FGF2	0.008
2810	Dr hemagglutinin structural subunit	draA	0.0079
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0079
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0079
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0079
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0079
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0079
705	Glutamate receptor 1	GRIA1	0.0078
2599	Tyrosine-protein kinase HCK	HCK	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
88	Retinoic acid receptor RXR-beta	RXRB	0.0078
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
543	Penicillin-binding protein 1B	mrcB	0.0077
6186	Penicillin-binding protein 1B	ponB	0.0077
6822	Penicillin-binding protein 1b	pbp1b	0.0077
6844	Penicillin-binding protein 1b	pbp1b	0.0077
2298	Cytochrome P450-cam	camC	0.0076
563	Thyroid peroxidase	TPO	0.0076
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0076
4226	Uridine phosphorylase 2	UPP2	0.0075
2021	Thrombomodulin	THBD	0.0075
6221	Steroid hormone receptor ERR1	ESRRA	0.0075
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
1541	Metalloproteinase	mmp20	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
174	Sigma 1-type opioid receptor	SIGMAR1	0.0073
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0072
54	Prothrombin	F2	0.0071
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0071
6174	50S ribosomal protein L32	rpmF	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.007
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0069
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0069
4225	Uridine phosphorylase 1	UPP1	0.0069
130	Prostacyclin synthase	PTGIS	0.0069
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0069
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0068
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0068
16	Adenosine A1 receptor	ADORA1	0.0068
3086	Plasmepsin-2	Not Available	0.0068
106	Cannabinoid receptor 2	CNR2	0.0068
1483	Membrane copper amine oxidase	AOC3	0.0067
4311	tRNA	TRDMT1	0.0067
4325	tRNA	trmD	0.0067
4328	tRNA	trmD	0.0067
527	Prostacyclin receptor	PTGIR	0.0066
65	Matrix metalloproteinase-9	Not Available	0.0066
4217	Telomerase reverse transcriptase	TERT	0.0065
413	Amidophosphoribosyltransferase	PPAT	0.0065
2515	Amidophosphoribosyltransferase	purF	0.0065
3714	Amidophosphoribosyltransferase	purF	0.0065
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0065
1275	Estrogen sulfotransferase	SULT1E1	0.0064
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0064
936	Ephrin type-A receptor 2	EPHA2	0.0063
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
277	Purine nucleoside phosphorylase	PNP	0.0062
2870	Purine nucleoside phosphorylase	punA	0.0062
2945	Purine nucleoside phosphorylase	punA	0.0062
4659	Purine nucleoside phosphorylase	TM_1596	0.0062
4825	Purine nucleoside phosphorylase	TTHA1435	0.0062
780	Retinoic acid receptor RXR-gamma	RXRG	0.0062
153	Dopamine beta-hydroxylase	DBH	0.0061
1291	cAMP response element-binding protein	CREB1	0.0061
856	Vitamin D3 receptor	VDR	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.006
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0059
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0059
2232	Interleukin-5	IL5	0.0059
1593	Mucin-2	MUC2	0.0059
4210	Toll-like receptor 4	TLR4	0.0059
4103	Proteasome subunit beta type 2	PSMB2	0.0059
4102	Proteasome subunit beta type 5	PSMB5	0.0059
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0059
4101	Proteasome subunit beta type 1	PSMB1	0.0059
634	Squalene monooxygenase	SQLE	0.0058
7196	Squalene monooxygenase	ERG1	0.0058
518	Peroxidase/catalase T	katG	0.0058
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0057
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0057
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0057
484	Tyrosine-protein kinase ABL2	ABL2	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0056
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0056
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0056
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0056
459	Retinoic acid receptor RXR-alpha	RXRA	0.0056
6432	Transporter	snf	0.0055
6506	Stathmin-4	STMN4	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
1864	RET proto-oncogene	RET	0.0054
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0054
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0054
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0054
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0054
1714	Mitogen-activated protein kinase 3	MAPK3	0.0053
162	Retinoic acid receptor gamma-1	RARG	0.0052
1792	Tissue-type plasminogen activator	PLAT	0.0052
3913	Glutamic acid decarboxylase	GAD65	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.005
581	Cytochrome P450 2R1	CYP2R1	0.005
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.005
482	Glycine receptor subunit alpha-1	GLRA1	0.005
6048	Troponin C, skeletal muscle	TNNC2	0.005
1123	Eosinophil cationic protein	RNASE3	0.0049
173	Toll-like receptor 7	TLR7	0.0049
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0048
6131	Carbonic anhydrase 14	CA14	0.0048
760	Fibroblast growth factor 1	FGF1	0.0048
6228	Nuclear receptor coactivator 1	NCOA1	0.0047
707	72 kDa type IV collagenase	MMP2	0.0047
6241	Nuclear receptor coactivator 2	NCOA2	0.0047
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0047
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
1648	Elastin	ELN	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0045
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0045
6122	Carbonic anhydrase 3	CA3	0.0045
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0043
3904	Alanine aminotransferase 2	GPT2	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
115	Penicillin-binding protein 2	mrdA	0.0041
6069	Penicillin-binding protein 2	mrdA	0.0041
6118	Penicillin-binding protein 2	penA	0.0041
6187	Penicillin-binding protein 2	pbpA	0.0041
6686	Penicillin-binding protein 2	pbp2	0.0041
6939	Penicillin-binding protein 2	mrdA	0.0041
7163	Penicillin-binding protein 2	pbpA	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
408	Riboflavin kinase	RFK	0.0041
5798	Mitogen-activated protein kinase 11	MAPK11	0.0041
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3426	Glutamine synthetase	glnA	0.004
3987	Glutamine synthetase	GLUL	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
4041	Microsomal glutathione S-transferase 2	MGST2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0038
1	Peptidoglycan synthetase ftsI	ftsI	0.0038
4155	Peptidoglycan synthetase ftsI	ftsI	0.0038
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0038
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
164	Histamine H4 receptor	HRH4	0.0038
1992	Vitamin D-binding protein	GC	0.0038
719	Retinoic acid receptor responder protein 1	RARRES1	0.0038
770	Retinoic acid-induced protein 3	GPRC5A	0.0038
85	Growth hormone receptor	GHR	0.0038
3007	Carbonic anhydrase 12	CA12	0.0038
4205	Carbonic anhydrase 9	CA9	0.0038
5353	Glutamate decarboxylase alpha	gadA	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0037
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0037
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0037
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0037
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
1867	Major prion protein	PRNP	0.0036
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0036
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0036
340	Apoptotic protease-activating factor 1	APAF1	0.0035
1039	Histone deacetylase 9	HDAC9	0.0035
1262	Corticotropin-lipotropin	POMC	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0035
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0035
1025	Aquaporin-1	AQP1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0034
1928	Leukotriene C4 synthase	LTC4S	0.0034
4034	Glutaredoxin-1	GLRX	0.0034
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0034
4037	Hypothetical protein	GPX1	0.0034
4297	Hypothetical protein	SP_1951	0.0034
4521	Hypothetical protein	BC_2969	0.0034
4540	Hypothetical protein	TM_1070	0.0034
4555	Hypothetical protein	MT1739	0.0034
4569	Hypothetical protein	mshD	0.0034
4578	Hypothetical protein	PA3270	0.0034
4747	Hypothetical protein	PA3967	0.0034
5177	Hypothetical protein	TM_0096	0.0034
5194	Hypothetical protein	PA1204	0.0034
5240	Hypothetical protein	Rv2991	0.0034
5370	Hypothetical protein	TM_1158	0.0034
5710	Hypothetical protein	Tb927.5.1360	0.0034
907	Glutathione peroxidase 2	GPX2	0.0034
4029	Microsomal glutathione S-transferase 3	MGST3	0.0034
4032	Microsomal glutathione S-transferase 1	MGST1	0.0034
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0034
910	Epididymal secretory glutathione peroxidase	GPX5	0.0034
4040	Glutathione peroxidase 7	GPX7	0.0034
4036	Glutathione peroxidase 6	GPX6	0.0034
903	Glutathione S-transferase A5	GSTA5	0.0034
906	Glutathione peroxidase 1	GPX1	0.0034
900	Glutathione S-transferase A4	GSTA4	0.0034
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0034
911	Glutathione peroxidase 3	GPX3	0.0034
4035	Glutathione S-transferase Mu 5	GSTM5	0.0034
4033	S-formylglutathione hydrolase	ESD	0.0034
4038	Glutathione peroxidase 4	GPX4	0.0034
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0034
4042	Glutathione transferase omega-2	GSTO2	0.0034
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0034
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0033
569	Retinal dehydrogenase 2	ALDH1A2	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
229	Retinoic acid receptor beta	RARB	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
6207	30S ribosomal protein S14	rpsN	0.0031
730	Retinoic acid receptor alpha	RARA	0.0031
6209	30S ribosomal protein S19	rpsS	0.0031
6712	30S ribosomal protein S19	rpsS	0.0031
6726	30S ribosomal protein S19	rpsS	0.0031
611	Retinal dehydrogenase 1	ALDH1A1	0.0031
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
4031	Glutathione S-transferase A1	GSTA1	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
898	Glutathione S-transferase A3	GSTA3	0.0031
897	Glutathione S-transferase kappa 1	GSTK1	0.0031
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0031
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.003
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.003
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
909	Maleylacetoacetate isomerase	GSTZ1	0.003
905	Glutathione transferase omega-1	GSTO1	0.003
899	Glutathione S-transferase Mu 3	GSTM3	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
654	Flavin reductase	BLVRB	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0029
292	Activin receptor type-1	ACVR1	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
849	Activated CDC42 kinase 1	TNK2	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0028
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
2165	Glutathione S-transferase Mu 2	GSTM2	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3685	Catabolite gene activator	crp	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0027
605	Fumarate reductase flavoprotein subunit	frdA	0.0027
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0027
3673	Fumarate reductase flavoprotein subunit	fccA	0.0027
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0027
6549	Fumarate reductase flavoprotein subunit	frdA	0.0027
4655	Adenylate cyclase	cyaC	0.0027
4759	Adenylate cyclase	cyaB2	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0027
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0026
207	Glutathione synthetase	GSS	0.0026
5269	Glutathione synthetase	gshB	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0026
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
3937	Fatty-acid amide hydrolase	FAAH	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0025
901	Glutathione S-transferase Mu 4	GSTM4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
3957	Adenosine deaminase	ADA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
1374	Natriuretic peptides B	NPPB	0.0024
1827	Gap junction alpha-1 protein	GJA1	0.0024
1908	Vascular cell adhesion protein 1	VCAM1	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
4760	Mll3241 protein	mll3241	0.0023
6021	Adenosine kinase	ADK	0.0023
268	Adenosine A2b receptor	ADORA2B	0.0023
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0022
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0022
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0022
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0022
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0022
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0022
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0022
714	Glutathione reductase, mitochondrial	GSR	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
298	Renin	REN	0.0021
1507	Cytochrome c	CYCS	0.0021
1198	Serum paraoxonase/arylesterase 1	PON1	0.0021
6223	Penicillin-binding protein 1C	pbpC	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
2207	Rhodopsin	RHO	0.0021
672	Prostaglandin F2-alpha receptor	PTGFR	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6459	Glycodelin	PAEP	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1058	Cell division protein kinase 5	CDK5	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
867	Penicillin-binding protein 3	pbpC	0.0019
6119	Penicillin-binding protein 3	pbp3	0.0019
7154	Penicillin-binding protein 3	pbp3	0.0019
7157	Penicillin-binding protein 3	LMHCC_2184	0.0019
7162	Penicillin-binding protein 3	pbpB	0.0019
7172	Penicillin-binding protein 3	pbp3	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
444	Alcohol dehydrogenase 1B	ADH1B	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
3830	Calreticulin	CALR	0.0017
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
2408	Tyrosine-protein kinase SYK	SYK	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
494	Caspase-1	CASP1	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
1405	Thiopurine S-methyltransferase	TPMT	0.0015
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3760	Penicillin-binding protein 5 precursor	dacA	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
822	Aldose reductase	AKR1B1	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
2077	Caspase-3	CASP3	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
819	Penicillin-binding protein 4	dacB	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
3221	Cytochrome c4	cc4	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
6859	Protein S100-A4	S100A4	0.0012
2236	Casein kinase II subunit alpha	CSNK2A1	0.0012
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0011
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
997	Protein kinase C beta type	PRKCB	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
2091	Endoplasmin	HSP90B1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
2802	Endoglucanase G	celCCG	0.0004
4920	Peroxidase/catalase	katG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
358	Cystathionine beta-synthase	CBS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00091 - Cyclosporine

Targets

Enzymes

Transporters

Predictions