DT-Web

DB01015 - Sulfamethoxazole


Identification
Name Sulfamethoxazole
Accession Number DB01015 (APRD00076)
Type small molecule
Description A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 253.278
Groups approved
Monoisotopic Weight 253.052111923
Pharmacology
Indication For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections.
Mechanism of action Sulfonamides inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis. THF is required for the synthesis of purines and dTMP and inhibition of its synthesis inhibits bacterial growth. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, another step in THF synthesis, and therefore act synergistically with the sulfonamides.
Absorption Rapidly absorbed following oral administration. Also well-absorbed topically.
Protein binding 70%
Biotransformation Hepatic. The metabolism of sulfamethoxazole occurs predominately by N4-acetylation, although the glucuronide conjugate has been identified.
Route of elimination Not Available
Toxicity Sulfamethoxazole may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.
Affected organisms
  • Gram negative and gram positive bacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Chlorpropamide Sulfonamide/sulfonylurea: possible hypoglycemia
Cyclosporine The sulfonamide decreases the effect of cyclosporine
Methotrexate The sulfamide increases the toxicity of methotrexate
Pralatrexate Decreases renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects.
Tobramycin Increased risk of nephrotoxicity
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Sulfamethoxazole. Consider alternate therapy or monitor for changes in Sulfamethoxazole therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Warfarin Sulfamethoxazole may increase the anticoagulant effect of warfarin by decreasing its metabolism. Consider alternate therapy or monitor for changes in prothrombin time if sulfamethoxazole is initiated, discontinued or dose changed.
Food Interactions
  • Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Take with a full glass of water.

Targets


Dihydropteroate synthase
Name Dihydropteroate synthase
Gene Name folP
Pharmacological action yes
Actions inhibitor
References
  • Hong YL, Hossler PA, Calhoun DH, Meshnick SR: Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63. - Pubmed
DTHybrid score 0.9979
FolC bifunctional protein [Includes: Folylpolyglutamate synthase
Name FolC bifunctional protein [Includes: Folylpolyglutamate synthase
Gene Name folC
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Winstanley PA, Mberu EK, Szwandt IS, Breckenridge AM, Watkins WM: In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs. Antimicrob Agents Chemother. 1995 Apr;39(4):948-52. - Pubmed
DTHybrid score 0.8233

Enzymes


Arylamine N-acetyltransferase 1
Name Arylamine N-acetyltransferase 1
Gene Name NAT1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3205
Arylamine N-acetyltransferase 2
Name Arylamine N-acetyltransferase 2
Gene Name NAT2
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.2897
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Cribb AE, Spielberg SP, Griffin GP: N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes. Drug Metab Dispos. 1995 Mar;23(3):406-14. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5992
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5945
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.378
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4011
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5542

Carriers


Predictions


Id Partner name Gene Name Score
5359 Dihydropteroate synthase folP 0.9979
7175 Dihydropteroate synthase sulI 0.9979
6016 Cytochrome P450 2C19 CYP2C19 0.2554
290 Prostaglandin G/H synthase 2 PTGS2 0.2305
4119 Cytochrome P450 2D6 CYP2D6 0.223
4200 Cytochrome P450 1A2 CYP1A2 0.1858
1588 Multidrug resistance protein 1 ABCB1 0.1759
4118 Cytochrome P450 3A5 CYP3A5 0.1466
3281 Isoaspartyl dipeptidase iadA 0.1463
6013 Cytochrome P450 2E1 CYP2E1 0.1337
6030 Cytochrome P450 2B6 CYP2B6 0.1268
2796 Parathion hydrolase opd 0.1148
6539 Parathion hydrolase opd 0.1148
5718 Cytochrome P450 2A6 CYP2A6 0.1137
6107 Cytochrome P450 3A7 CYP3A7 0.1042
1729 Solute carrier family 22 member 6 SLC22A6 0.0951
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0945
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0731
6024 Cytochrome P450 1A1 CYP1A1 0.0715
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0652
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0649
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0649
6106 Cytochrome P450 2C18 CYP2C18 0.0586
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0549
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0506
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0458
2164 Multidrug resistance-associated protein 4 ABCC4 0.0437
6142 Solute carrier family 22 member 8 SLC22A8 0.0435
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0424
275 Arachidonate 5-lipoxygenase ALOX5 0.0393
862 Multidrug resistance-associated protein 1 ABCC1 0.0388
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0375
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0375
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0359
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0346
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0341
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0338
1024 Solute carrier family 22 member 11 SLC22A11 0.033
1757 Myeloperoxidase MPO 0.0325
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.032
847 Mu-type opioid receptor OPRM1 0.0302
3811 Cytochrome P450 19A1 CYP19A1 0.0297
492 Histamine H1 receptor HRH1 0.0297
6143 Solute carrier family 22 member 7 SLC22A7 0.0291
467 Delta-type opioid receptor OPRD1 0.0286
696 Kappa-type opioid receptor OPRK1 0.0284
3810 Catechol O-methyltransferase COMT 0.0282
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0278
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0275
518 Peroxidase/catalase T katG 0.0274
502 5-hydroxytryptamine 2A receptor HTR2A 0.0272
136 Estrogen receptor ESR1 0.0264
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0264
824 Sodium-dependent serotonin transporter SLC6A4 0.0263
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0261
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.026
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0259
1898 Cytochrome P450 1B1 CYP1B1 0.0258
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0249
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0247
4604 Liver carboxylesterase 1 CES1 0.0246
6145 Solute carrier family 22 member 1 SLC22A1 0.0244
3601 Dihydropteroate synthase 1 folP1 0.0243
3807 Dihydropteroate synthase 1 folP1 0.0243
3808 Dihydropteroate synthase 2 folP2 0.0243
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0241
811 Translocator protein TSPO 0.0237
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0236
831 D(2) dopamine receptor DRD2 0.0235
871 Glucocorticoid receptor NR3C1 0.023
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0227
738 Monocarboxylate transporter 1 SLC16A1 0.0221
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0219
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0211
70 Type-1 angiotensin II receptor AGTR1 0.021
1050 Bile salt sulfotransferase SULT2A1 0.0207
776 Bile salt export pump ABCB11 0.0202
1275 Estrogen sulfotransferase SULT1E1 0.0194
556 Alpha-1A adrenergic receptor ADRA1A 0.0191
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0187
1192 Sulfotransferase 1A1 SULT1A1 0.0185
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0181
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0181
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0181
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0181
23 D(1A) dopamine receptor DRD1 0.0181
118 Organic cation/carnitine transporter 2 SLC22A5 0.0174
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0174
320 5-hydroxytryptamine 1A receptor HTR1A 0.0171
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.017
731 HIV-1 protease HIV-1 protease 0.017
341 5-hydroxytryptamine 3 receptor HTR3A 0.017
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0169
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0168
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0168
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0168
6085 Fatty acid-binding protein, intestinal FABP2 0.0168
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0167
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0162
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0162
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0162
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0162
6144 Solute carrier family 22 member 2 SLC22A2 0.016
122 P2Y purinoceptor 12 P2RY12 0.016
373 Transthyretin TTR 0.0159
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0159
504 Mast/stem cell growth factor receptor KIT 0.0159
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0158
146 Androgen receptor AR 0.0156
3923 Cholinesterase BCHE 0.0154
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0152
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0152
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0152
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0152
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0152
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0151
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.015
260 Cytochrome P450 51 ERG11 0.0148
761 Cytochrome P450 51 ERG11 0.0148
3163 Cytochrome P450 51 cyp51 0.0148
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0145
2183 Fatty acid-binding protein, adipocyte FABP4 0.0145
4132 Chloride channel protein ClC-Ka CLCNKA 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
632 Alpha-1B adrenergic receptor ADRA1B 0.0142
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0141
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0141
6031 Cytochrome P450 3A43 CYP3A43 0.0141
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0139
6141 Sodium/bile acid cotransporter SLC10A1 0.0137
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0136
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0134
318 Alpha-2A adrenergic receptor ADRA2A 0.0131
459 Retinoic acid receptor RXR-alpha RXRA 0.0128
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0128
590 5-hydroxytryptamine 2C receptor HTR2C 0.0123
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.012
756 Sex hormone-binding globulin SHBG 0.012
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.012
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0119
1507 Cytochrome c CYCS 0.0116
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0116
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0115
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0115
6147 Solute carrier family 22 member 3 SLC22A3 0.0115
6043 Putative G-protein coupled receptor 44 GPR44 0.0114
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0113
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0112
614 Progesterone receptor PGR 0.0111
723 Cytosolic phospholipase A2 PLA2G4A 0.0111
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0111
558 Solute carrier family 12 member 1 SLC12A1 0.011
468 Cytochrome P450 4A11 CYP4A11 0.011
844 Epidermal growth factor receptor EGFR 0.011
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0109
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0108
6137 Multidrug resistance-associated protein 6 ABCC6 0.0108
2211 Fatty acid-binding protein, heart FABP3 0.0108
6182 Cytochrome P450 2J2 CYP2J2 0.0106
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0106
2853 14 kDa fatty acid-binding protein Not Available 0.0105
407 Vascular endothelial growth factor receptor 2 KDR 0.0105
489 Monocarboxylate transporter 2 SLC16A7 0.0105
228 Beta platelet-derived growth factor receptor PDGFRB 0.0104
3312 Fatty acid-binding protein, brain FABP7 0.0104
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0103
713 Sodium-dependent dopamine transporter SLC6A3 0.0103
766 Beta-2 adrenergic receptor ADRB2 0.0103
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0102
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.01
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0098
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
183 Vascular endothelial growth factor A VEGFA 0.0097
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0097
3941 Amine oxidase [flavin-containing] A MAOA 0.0096
482 Glycine receptor subunit alpha-1 GLRA1 0.0096
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0096
26 Vascular endothelial growth factor receptor 3 FLT4 0.0095
566 Serotransferrin TF 0.0094
465 Calmodulin CALM1 0.0094
789 Alpha-1D adrenergic receptor ADRA1D 0.0093
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0093
54 Prothrombin F2 0.0092
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0092
6136 Multidrug resistance-associated protein 5 ABCC5 0.0092
705 Glutamate receptor 1 GRIA1 0.0091
32 Vascular endothelial growth factor receptor 1 FLT1 0.0091
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0091
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0091
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0091
638 D(3) dopamine receptor DRD3 0.009
6500 Phospholipase A2 PLA2G1B 0.009
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
869 Estrogen receptor beta ESR2 0.0087
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0086
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0086
380 Cytochrome P450 17A1 CYP17A1 0.0084
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0084
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0082
537 ATP synthase delta chain, mitochondrial ATP5D 0.0082
185 Vasopressin V1a receptor AVPR1A 0.0082
427 Substance-P receptor TACR1 0.0082
29 Tubulin beta-1 chain TUBB1 0.0081
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0081
365 Dihydrofolate reductase DHFR 0.0081
2381 Dihydrofolate reductase DFR1 0.0081
2833 Dihydrofolate reductase Not Available 0.0081
2931 Dihydrofolate reductase folA 0.0081
3544 Dihydrofolate reductase folA 0.0081
3682 Dihydrofolate reductase folA 0.0081
6642 Dihydrofolate reductase folA 0.0081
6756 Dihydrofolate reductase dfrA 0.0081
1648 Elastin ELN 0.0081
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0081
885 5-hydroxytryptamine 1B receptor HTR1B 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
322 Vasopressin V2 receptor AVPR2 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
6148 Multidrug resistance-associated protein 7 ABCC10 0.0079
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0079
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0077
817 DNA topoisomerase 2-alpha TOP2A 0.0076
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0076
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0076
1618 High affinity nerve growth factor receptor NTRK1 0.0075
777 Tumor necrosis factor TNF 0.0075
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0074
823 Fibroblast growth factor receptor 2 FGFR2 0.0074
1541 Metalloproteinase mmp20 0.0074
725 5-hydroxytryptamine 1D receptor HTR1D 0.0074
5300 Antigen peptide transporter 1 TAP1 0.0074
88 Retinoic acid receptor RXR-beta RXRB 0.0073
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
3939 Amine oxidase [flavin-containing] B MAOB 0.0072
6014 Cytochrome P450 2A13 CYP2A13 0.0072
130 Prostacyclin synthase PTGIS 0.0072
436 5-hydroxytryptamine 2B receptor HTR2B 0.0072
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
5787 Angiopoietin-1 receptor TEK 0.0071
629 Alpha-2B adrenergic receptor ADRA2B 0.007
952 Dipeptidyl peptidase 4 DPP4 0.0069
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0069
49 Endothelin B receptor EDNRB 0.0069
68 Cannabinoid receptor 1 CNR1 0.0069
833 Organic cation/carnitine transporter 1 SLC22A4 0.0069
2021 Thrombomodulin THBD 0.0069
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0068
295 Carbonic anhydrase 1 CA1 0.0068
6033 High affinity interleukin-8 receptor A CXCR1 0.0068
592 Carbonic anhydrase 4 CA4 0.0067
24 Thymidylate synthase TMP1 0.0066
359 Thymidylate synthase TYMS 0.0066
2626 Thymidylate synthase thyA 0.0066
2729 Thymidylate synthase thyA 0.0066
5352 Thymidylate synthase THYA 0.0066
36 Insulin receptor INSR 0.0066
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0065
2981 Phospholipase A2, membrane associated PLA2G2A 0.0064
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0064
193 Beta-1 adrenergic receptor ADRB1 0.0064
1629 Transcription factor AP-1 JUN 0.0064
273 Apoptosis regulator Bcl-2 BCL2 0.0064
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
133 Dihydropterate synthase sulI 0.0063
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0062
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0062
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0062
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
3932 Glutathione S-transferase A2 GSTA2 0.0061
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0061
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.006
357 Carbonic anhydrase 2 CA2 0.006
6149 Solute carrier family 22 member 10 SLC22A10 0.0059
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
378 Alpha-2C adrenergic receptor ADRA2C 0.0059
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0059
818 50S ribosomal protein L10 rplJ 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
716 5-hydroxytryptamine 7 receptor HTR7 0.0057
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0057
703 NADPH azoreductase azr 0.0056
780 Retinoic acid receptor RXR-gamma RXRG 0.0056
4120 NADPH--cytochrome P450 reductase POR 0.0055
1353 DNA topoisomerase 1 TOP1 0.0054
3552 DNA topoisomerase 1 topA 0.0054
737 Mineralocorticoid receptor NR3C2 0.0054
3809 Estrogen-related receptor gamma ESRRG 0.0054
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0054
94 5-hydroxytryptamine 4 receptor HTR4 0.0053
5287 Signaling protein Not Available 0.0053
5304 UPF0166 protein TM_0021 TM_0021 0.0053
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0053
3199 Phosphopantetheine adenylyltransferase coaD 0.0053
3543 Phosphopantetheine adenylyltransferase coaD 0.0053
3567 Phosphopantetheine adenylyltransferase coaD 0.0053
5289 Phosphopantetheine adenylyltransferase coaD 0.0053
5293 Shikimate kinase 2 aroL 0.0053
5288 Shikimate kinase aroK 0.0053
4346 Polynucleotide kinase pseT 0.0053
5281 Plasmid segregation protein parM parM 0.0053
5292 Putative partitioning protein TT_C1605 0.0053
5266 Activator of hgdC 0.0053
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0053
2874 Nitrogenase iron protein 1 nifH1 0.0053
5283 D-alanine--D-alanine ligase B ddlB 0.0053
5291 Glycogen synthase 1 glgA1 0.0053
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0053
7 Nitric oxide synthase, inducible NOS2 0.0053
5299 D-alanine--D-alanine ligase ddl 0.0053
6598 D-alanine--D-alanine ligase ddl 0.0053
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0053
5276 Chromosomal replication initiator protein dnaA dnaA 0.0053
5315 Chaperone protein htpG htpG 0.0053
5259 Transcriptional regulator ntrC1 0.0053
6699 Transcriptional regulator Cgl2612 0.0053
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0053
5284 Large T antigen Not Available 0.0053
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0053
5264 DNA replication protein REP 0.0053
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0053
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0053
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0053
5261 Phosphoribosylformylglycinamidine synthase purL 0.0053
5277 Preprotein translocase subunit secA secA 0.0053
5308 Preprotein translocase secA 1 subunit secA1 0.0053
5285 Kinesin heavy chain KIF5B 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
594 Thyroxine-binding globulin SERPINA7 0.0053
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0053
6020 Aldehyde oxidase AOX1 0.0052
161 Tubulin beta chain TUBB 0.0052
312 Tubulin beta chain TUB2 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
1039 Histone deacetylase 9 HDAC9 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0051
3937 Fatty-acid amide hydrolase FAAH 0.0051
634 Squalene monooxygenase SQLE 0.005
7196 Squalene monooxygenase ERG1 0.005
165 FL cytokine receptor FLT3 0.005
1656 CYP2B protein CYP2B 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0049
5798 Mitogen-activated protein kinase 11 MAPK11 0.0049
758 Thyroid hormone receptor alpha THRA 0.0049
1010 Cytochrome P450 51A1 CYP51A1 0.0049
856 Vitamin D3 receptor VDR 0.0049
814 Ryanodine receptor 1 RYR1 0.0048
921 Glutamate receptor 2 GRIA2 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
162 Retinoic acid receptor gamma-1 RARG 0.0048
1792 Tissue-type plasminogen activator PLAT 0.0048
432 D(4) dopamine receptor DRD4 0.0048
6220 Aryl hydrocarbon receptor AHR 0.0047
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0047
3382 Glycolipid transfer protein GLTP 0.0046
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0046
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0046
6042 Prostaglandin reductase 2 PTGR2 0.0046
267 Plasminogen activator inhibitor 1 SERPINE1 0.0045
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
527 Prostacyclin receptor PTGIR 0.0045
2207 Rhodopsin RHO 0.0045
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0045
768 FK506-binding protein 1A FKBP1A 0.0045
474 Acetylcholinesterase ACHE 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0044
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
3470 Hypothetical protein MG245 homolog MPN_348 0.0044
6277 Heat shock cognate 71 kDa protein HSPA8 0.0044
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0044
4106 Guanylate kinase GUK1 0.0044
4516 Guanylate kinase gmk 0.0044
5189 Trimethylamine dehydrogenase tmd 0.0044
4837 Cag-alfa cag-alfa 0.0044
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0044
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0044
4774 NTPase P4 Not Available 0.0044
5646 Galactokinase GALK1 0.0044
5302 TrwB trwB 0.0044
2270 Dephospho-CoA kinase coaE 0.0044
5265 FtsH ftsH 0.0044
4839 DNA polymerase III subunit tau dnaX 0.0044
2284 Adenylate kinase adk 0.0044
2296 Adenylate kinase adk 0.0044
2311 Adenylate kinase adk 0.0044
2312 Adenylate kinase Not Available 0.0044
4838 PMS1 protein homolog 2 PMS2 0.0044
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0044
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0044
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0044
3426 Glutamine synthetase glnA 0.0044
3987 Glutamine synthetase GLUL 0.0044
3175 Glutamate--cysteine ligase gshA 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
346 Thyroid hormone receptor beta-1 THRB 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
1714 Mitogen-activated protein kinase 3 MAPK3 0.0044
528 5-hydroxytryptamine 1E receptor HTR1E 0.0044
633 Penicillin-binding proteins 1A/1B pbpA 0.0043
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0043
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0043
6221 Steroid hormone receptor ERR1 ESRRA 0.0042
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0042
1992 Vitamin D-binding protein GC 0.0042
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0042
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
106 Cannabinoid receptor 2 CNR2 0.0041
2683 Mono-ADP-ribosyltransferase C3 C3 0.0041
6677 Myelin P2 protein PMP2 0.0041
4773 Deoxycytidine kinase DCK 0.0041
229 Retinoic acid receptor beta RARB 0.0041
936 Ephrin type-A receptor 2 EPHA2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1881 Hexokinase-1 HK1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
5271 Focal adhesion kinase 1 PTK2 0.004
3947 Xanthine dehydrogenase/oxidase XDH 0.004
730 Retinoic acid receptor alpha RARA 0.004
2390 Nonsecretory ribonuclease RNASE2 0.004
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.004
5312 Kinesin-like protein KIF1A KIF1A 0.004
2922 Glycerol kinase glpK 0.004
340 Apoptotic protease-activating factor 1 APAF1 0.0039
4210 Toll-like receptor 4 TLR4 0.0039
6138 Multidrug resistance protein 3 ABCB4 0.0039
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
2091 Endoplasmin HSP90B1 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0038
904 Glutathione S-transferase P GSTP1 0.0038
408 Riboflavin kinase RFK 0.0038
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0037
2615 Chemotaxis protein cheA cheA 0.0037
2892 Acetylglutamate kinase argB 0.0037
3550 Acetylglutamate kinase argB 0.0037
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0037
284 DNA-directed RNA polymerase beta chain rpoB 0.0037
5773 DNA-directed RNA polymerase beta chain rpoB 0.0037
2371 Pantothenate kinase coaA 0.0037
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0037
3669 Ribokinase rbsK 0.0037
825 Arsenical pump-driving ATPase ASNA1 0.0037
3435 Arsenical pump-driving ATPase arsA 0.0037
2282 Protein recA recA 0.0037
2315 Protein recA recA 0.0037
2332 Protein recA recA 0.0037
5263 Protein recA recA 0.0037
6146 High affinity copper uptake protein 1 SLC31A1 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
4122 Histone deacetylase 2 HDAC2 0.0037
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0036
1291 cAMP response element-binding protein CREB1 0.0036
33 Cystine/glutamate transporter SLC7A11 0.0036
199 Monocarboxylate transporter 8 SLC16A2 0.0036
595 Fibrinogen alpha chain FGA 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
16 Adenosine A1 receptor ADORA1 0.0036
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0036
1313 Lactoylglutathione lyase GLO1 0.0036
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0035
2727 S-adenosylmethionine synthetase metK 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0035
788 Creatine kinase M-type CKM 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
1178 Adenosine A2a receptor ADORA2A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0035
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0035
124 Histamine H2 receptor HRH2 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
2697 Uridine-cytidine kinase 2 UCK2 0.0034
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0034
2334 Dethiobiotin synthetase bioD 0.0034
6555 Dethiobiotin synthetase bioD 0.0034
3639 Thymidine phosphorylase deoA 0.0034
3936 Thymidine phosphorylase TYMP 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0033
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0033
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0033
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0033
5880 Thrombopoietin receptor MPL 0.0033
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0033
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0032
1867 Major prion protein PRNP 0.0032
48 Pyridoxal kinase PDXK 0.0032
5934 Cytochrome P450 26A1 CYP26A1 0.0032
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
4217 Telomerase reverse transcriptase TERT 0.0032
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
6395 Myosin-14 MYH14 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
702 UMP-CMP kinase CMPK1 0.0031
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
2251 Thymidylate kinase tmk 0.003
2254 Thymidylate kinase DTYMK 0.003
3522 Thymidylate kinase tmk 0.003
207 Glutathione synthetase GSS 0.003
5269 Glutathione synthetase gshB 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
163 D(1B) dopamine receptor DRD5 0.003
1422 Serine/threonine-protein kinase 6 AURKA 0.003
3379 Kinesin-like protein KIF11 KIF11 0.003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0029
1256 5-hydroxytryptamine 6 receptor HTR6 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
1864 RET proto-oncogene RET 0.0028
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0028
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0028
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0028
3822 Actin, alpha skeletal muscle ACTA1 0.0028
233 Potassium channel subfamily K member 2 KCNK2 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
1517 Beta-3 adrenergic receptor ADRB3 0.0028
822 Aldose reductase AKR1B1 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
4226 Uridine phosphorylase 2 UPP2 0.0028
1525 Heparin-binding growth factor 2 FGF2 0.0028
5431 Lipid binding protein Not Available 0.0028
3616 Fatty acid-binding protein, epidermal FABP5 0.0028
5433 UPF0230 protein TM_1468 TM_1468 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0028
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
6131 Carbonic anhydrase 14 CA14 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
84 Nuclear receptor 0B1 NR0B1 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
509 Thymidine kinase TK 0.0027
570 Thymidine kinase TK 0.0027
2559 Thymidine kinase TK 0.0027
3430 Thymidine kinase tdk 0.0027
3518 Thymidine kinase TK 0.0027
5301 Thymidine kinase tdk 0.0027
5771 Thymidine kinase ORF36 0.0027
7009 Thymidine kinase ORF36 0.0027
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0027
469 Annexin A1 ANXA1 0.0027
239 Coagulation factor X F10 0.0027
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0027
5294 Nucleoside diphosphate kinase A NME1 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0027
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0026
1721 Glycogen synthase kinase-3 beta GSK3B 0.0026
1374 Natriuretic peptides B NPPB 0.0026
1827 Gap junction alpha-1 protein GJA1 0.0026
1908 Vascular cell adhesion protein 1 VCAM1 0.0026
4225 Uridine phosphorylase 1 UPP1 0.0026
3856 Fibroblast growth factor receptor 3 FGFR3 0.0026
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0026
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0025
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
1650 Heme carrier protein 1 SLC46A1 0.0025
2320 Thymidine kinase, cytosolic TK1 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0025
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
5682 Ribonuclease pancreatic RNASE1 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
413 Amidophosphoribosyltransferase PPAT 0.0024
2515 Amidophosphoribosyltransferase purF 0.0024
3714 Amidophosphoribosyltransferase purF 0.0024
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0024
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
283 SEC14-like protein 2 SEC14L2 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
4192 DNA topoisomerase 2-beta TOP2B 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0023
2236 Casein kinase II subunit alpha CSNK2A1 0.0023
3917 Methylenetetrahydrofolate reductase MTHFR 0.0023
908 Glutathione S-transferase theta-1 GSTT1 0.0022
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0022
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0022
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0022
4311 tRNA TRDMT1 0.0022
4325 tRNA trmD 0.0022
4328 tRNA trmD 0.0022
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
6459 Glycodelin PAEP 0.0022
6218 Pannexin-1 PANX1 0.0022
164 Histamine H4 receptor HRH4 0.0022
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
319 Opioid receptor, sigma 1 OPRS1 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0021
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0021
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
707 72 kDa type IV collagenase MMP2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
244 Angiotensin-converting enzyme ACE 0.0021
976 Platelet glycoprotein IX GP9 0.0021
1630 Integrin beta-2 ITGB2 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0021
6432 Transporter snf 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
174 Sigma 1-type opioid receptor SIGMAR1 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
6151 Monocarboxylate transporter 10 SLC16A10 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0018
712 Tubulin alpha chain TUB1 0.0018
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
683 Potassium transporter GK0582 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
6044 Serum paraoxonase/lactonase 3 PON3 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
563 Thyroid peroxidase TPO 0.0016
572 Integrin alpha-L ITGAL 0.0016
173 Toll-like receptor 7 TLR7 0.0016
605 Fumarate reductase flavoprotein subunit frdA 0.0016
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0016
3673 Fumarate reductase flavoprotein subunit fccA 0.0016
4912 Fumarate reductase flavoprotein subunit ifcA 0.0016
6549 Fumarate reductase flavoprotein subunit frdA 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0015
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0015
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
4948 Cytochrome c-553 Not Available 0.0015
4923 Cytochrome c3 DvMF_2499 0.0015
4945 Cytochrome c3 Not Available 0.0015
4949 Cytochrome c3 DVU_3171 0.0015
4968 Cytochrome c3 cytc3 0.0015
4997 Cytochrome c3 SO_2727 0.0015
5219 Cytochrome c3 cyd 0.0015
6073 Potassium channel subfamily K member 9 KCNK9 0.0015
6072 Potassium channel subfamily K member 3 KCNK3 0.0015
4902 Nine-heme cytochrome c Ddes_2038 0.0015
3189 High-molecular-weight cytochrome c hmcA 0.0015
1341 Histamine H3 receptor HRH3 0.0014
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0014
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0014
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0014
751 Potassium channel subfamily K member 6 KCNK6 0.0013
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
4386 Hemoglobin-like protein HbN glbN 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
4943 Cytochrome c6 petJ 0.0012
4954 Soluble cytochrome b558 Not Available 0.0012
4916 Cyanoglobin glbN 0.0012
4947 Bacterial hemoglobin vhb 0.0012
4934 Cytochrome c-551 nirM 0.0012
5218 Cytochrome c-551 nirM 0.0012
4915 Cytochrome c-550 psbV 0.0012
4959 Cytochrome c-550 psbV 0.0012
5216 Cytochrome c-550 psbV 0.0012
4925 Cytochrome c-type protein SHP shp 0.0012
4905 Cytochrome c2 Not Available 0.0012
4939 Cytochrome c2 cycA 0.0012
4964 Cytochrome c2 cycA 0.0012
4979 Cytochrome c2 cycA 0.0012
6673 Cytochrome c2 cycA 0.0012
4994 Hemoglobin-like protein HbO glbO 0.0012
4975 Cytochrome c-556 RPA3973 0.0012
4942 Diheme cytochrome c napB napB 0.0012
4984 Neuroglobin NGB 0.0012
4936 Cytochrome c2 iso-2 Not Available 0.0012
5000 HemO hemO 0.0012
4981 Iron-starvation protein PigA pigA 0.0012
4998 Hemoglobin-like protein yjbI yjbI 0.0012
4961 Hemophore HasA hasA 0.0012
4909 CooA protein cooA 0.0012
3116 Bacterioferritin bfr 0.0012
4906 Bacterioferritin bfr 0.0012
4965 Bacterioferritin bfr 0.0012
4910 Cytoglobin CYGB 0.0012
4935 Cytochrome c-554 cycA1 0.0012
644 Heme oxygenase 2 HMOX2 0.0012
4982 Heme oxygenase 2 pbsA2 0.0012
4904 Cytochrome c family protein GSU1996 0.0012
4907 Cytochrome c-L moxG 0.0012
6865 Cytochrome c-L moxG 0.0012
4976 Apocytochrome f petA 0.0012
6407 Apocytochrome f petA 0.0012
4971 Nonaheme cytochrome c hmcA 0.0012
4937 Cytochrome oxidase subunit II rcoxA 0.0012
4989 Cytochrome c551 peroxidase ccp 0.0012
5222 Cytochrome c551 peroxidase ccpA 0.0012
4931 Cytochrome P450 167A1 CYP167A1 0.0012
4764 Cytochrome P450 165C4 CYP165C4 0.0012
4926 Heme-based aerotactic transducer hemAT hemAT 0.0012
4999 Cytochrome P450 165B3 CYP165B3 0.0012
4960 Putative cytochrome P450-family protein SCO7417 0.0012
4903 Methyl-accepting chemotaxis protein Tar4 0.0012
4972 P450cin cinA 0.0012
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0012
4922 Cytochrome c, putative SO_4144 0.0012
4993 Hydroxylamine oxidoreductase hao1 0.0012
4952 Catalase/peroxidase katA 0.0012
3093 Catalase HPII katE 0.0012
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0012
3957 Adenosine deaminase ADA 0.0011
3221 Cytochrome c4 cc4 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2298 Cytochrome P450-cam camC 0.0011
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
760 Fibroblast growth factor 1 FGF1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
291 Nitric-oxide synthase, endothelial NOS3 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
4920 Peroxidase/catalase katG 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
2119 Cytochrome b5 CYB5A 0.0009
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0009
4990 PpcA ppcA 0.0009
4988 Sulfite oxidase, mitochondrial SUOX 0.0009
4037 Hypothetical protein GPX1 0.0009
4297 Hypothetical protein SP_1951 0.0009
4521 Hypothetical protein BC_2969 0.0009
4540 Hypothetical protein TM_1070 0.0009
4555 Hypothetical protein MT1739 0.0009
4569 Hypothetical protein mshD 0.0009
4578 Hypothetical protein PA3270 0.0009
4747 Hypothetical protein PA3967 0.0009
5177 Hypothetical protein TM_0096 0.0009
5194 Hypothetical protein PA1204 0.0009
5240 Hypothetical protein Rv2991 0.0009
5370 Hypothetical protein TM_1158 0.0009
5710 Hypothetical protein Tb927.5.1360 0.0009
3375 Acidic cytochrome c3 Not Available 0.0008
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3570 Cytochrome P450 152A1 cypC 0.0008
2915 Sensor protein fixL fixL 0.0008
4944 Sensor protein fixL fixL 0.0008
3404 Exotoxin A eta 0.0008
4289 Cytochrome P450 TT_P0059 0.0008
6262 Cytochrome P450 staP 0.0008
4992 Cytochrome c peroxidase Not Available 0.0008
4385 Cytochrome c' Not Available 0.0008
4967 Cytochrome c' cycA 0.0008
5038 Cytochrome c' Not Available 0.0008
5223 Cytochrome c' cycP 0.0008
4813 Heme oxygenase hmuO 0.0008
5769 Heme oxygenase Not Available 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
1184 Interferon beta IFNB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2230 Catalase CAT 0.0008
3249 Catalase katA 0.0008
3625 Catalase katA 0.0008
4539 Catalase katA 0.0008
4941 Catalase katB 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0008
1025 Aquaporin-1 AQP1 0.0008
517 Alcohol dehydrogenase 1C ADH1C 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
3830 Calreticulin CALR 0.0008
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0008
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0008
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0008
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0008
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0008
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
3102 Flavohemoprotein hmp 0.0007
4969 Flavohemoprotein hmp 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
5818 Folate receptor alpha FOLR1 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
2972 6-deoxyerythronolide B hydroxylase eryF 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
358 Cystathionine beta-synthase CBS 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
693 Hemoglobin subunit beta HBB 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0005
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
2427 Ferrichrome-iron receptor fhuA 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
5961 Insulin INS 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
6755 Poliovirus receptor PVR 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
1439 Lactotransferrin LTF 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
2252 Endoglucanase 5A cel5A 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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