DT-Web: DB00672

Identification

Name

Chlorpropamide

Accession Number

DB00672 (APRD00029)

Type

small molecule

Description

Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating ? cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic ? cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Chlorpropamide is not recommended for the treatment of NIDDM as it increases blood pressure and the risk of retinopathy (UKPDS-33). Up to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites. Renal and hepatic dysfunction may increase the risk of hypoglycemia.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

276.74

Groups

approved

Monoisotopic Weight

276.033540689

Pharmacology

Indication

For treatment of NIDDM in conjunction with diet and exercise.

Mechanism of action

Sulfonylureas such as chlorpropamide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

Absorption

Readily absorbed from the GI tract. Peak plasma concentrations occur within 2-4 hours and the onset of action occurs within one hour. The maximal effect of chlorpropamide is seen 3-6 hours following oral administration.

Protein binding

Highly bound to plasma proteins.

Biotransformation

Up to 80% of dose is metabolized likely through the liver to to 2-hydroxylchlorpropamide (2-OH CPA), p-chlorobenzenesulfonylurea (CBSU), 3-hydroxylchlorpropamide (3-OH CPA), and p-chlorobenzenesulfonamide (CBSA); CBSA may be produced by decomposition in urine. It is unknown whether chlorpropamide metabolites exert hypoglycemic effects.

Route of elimination

80-90% of a single oral dose is excreted in the urine as unchaged drug and metabolites within 96 hours.

Toxicity

IPN-RAT LD₅₀ 580 mg/kg

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acebutolol	Acebutolol may decrease symptoms of hypoglycemia and increase the time required for the body to compensate for hypoglycemia.
Acetylsalicylic acid	Acetylsalicylic acid may increase the effect of the sulfonylurea, chlorpropamide.
Atenolol	The beta-blocker, atenolol, may decrease symptoms of hypoglycemia.
Betaxolol	The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Bevantolol	The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Bisoprolol	The beta-blocker, bisoprolol, may decrease symptoms of hypoglycemia.
Carteolol	The beta-blocker, carteolol, may decrease symptoms of hypoglycemia.
Carvedilol	The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Chloramphenicol	Chloramphenicol may increase the effect of sulfonylurea, chlorpropamide.
Clofibrate	Clofibrate may increase the effect of sulfonylurea, chlorpropamide.
Diazoxide	Antagonism.
Dicumarol	Dicumarol may increase the effect of sulfonylurea, chlorpropamide.
Esmolol	The beta-blocker, esmolol, may decrease symptoms of hypoglycemia.
Glucosamine	Possible hyperglycemia
Labetalol	The beta-blocker, labetalol, may decrease symptoms of hypoglycemia.
Metoprolol	The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Nadolol	The beta-blocker, nadolol, may decrease symptoms of hypoglycemia.
Oxprenolol	The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Penbutolol	The beta-blocker, penbutolol, may decrease symptoms of hypoglycemia.
Phenylbutazone	Phenylbutazone increases the effect of the hypoglycemic agent
Pindolol	The beta-blocker, pindolol, may decrease symptoms of hypoglycemia.
Practolol	The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Propranolol	The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Rifampin	Rifampin may decrease the effect of sulfonylurea, chlorpropamide.
Salsalate	The salicylate, salsalate, increases the effect of the sulfonylurea, chlorpropamide.
Somatropin recombinant	Somatropin may antagonize the hypoglycemic effect of chlorpropamide. Monitor for changes in fasting and postprandial blood sugars.
Sotalol	The beta-blocker, sotalol, may decrease symptoms of hypoglycemia.
Sulfacytine	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfadiazine	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfadoxine	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfamerazine	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfamethazine	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfamethizole	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfamethoxazole	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfapyridine	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfasalazine	Sulfonamide/sulfonylurea: possible hypoglycemia
Sulfisoxazole	Sulfonamide/sulfonylurea: possible hypoglycemia
Timolol	The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Trisalicylate-choline	The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, chlorpropamide.
Voriconazole	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Food reduces the rate of absorption.
Take 30 minutes before meal.
Avoid alcohol.

ATP-binding cassette transporter sub-family C member 8
Name	ATP-binding cassette transporter sub-family C member 8
Gene Name	ABCC8
Pharmacological action	yes
Actions	inhibitor
References	Mizuno CS, Chittiboyina AG, Kurtz TW, Pershadsingh HA, Avery MA: Type 2 diabetes and oral antihyperglycemic drugs. Curr Med Chem. 2008;15(1):61-74. - Pubmed
DTHybrid score	0.3535

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4347
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3418
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4751

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Ibrahim S, Peggins J, Knapton A, Licht T, Aszalos A: Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation. J Pharmacol Exp Ther. 2000 Dec;295(3):1276-83. - Pubmed
DTHybrid score	0.3239
Oligopeptide transporter, small intestine isoform
Name	Oligopeptide transporter, small intestine isoform
Gene Name	SLC15A1
Actions	inhibitor
References	Terada T, Sawada K, Saito H, Hashimoto Y, Inui K: Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol. 2000 Mar 24;392(1-2):11-7. - Pubmed
DTHybrid score	0.5434
Oligopeptide transporter, kidney isoform
Name	Oligopeptide transporter, kidney isoform
Gene Name	SLC15A2
Actions	inhibitor
References	Terada T, Sawada K, Saito H, Hashimoto Y, Inui K: Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2. Eur J Pharmacol. 2000 Mar 24;392(1-2):11-7. - Pubmed
DTHybrid score	0.5278
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Uwai Y, Saito H, Hashimoto Y, Inui K: Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1. Eur J Pharmacol. 2000 Jun 16;398(2):193-7. - Pubmed
DTHybrid score	0.3722

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.3024
290	Prostaglandin G/H synthase 2	PTGS2	0.1916
4924	Cytochrome P450 2C8	CYP2C8	0.1915
244	Angiotensin-converting enzyme	ACE	0.1846
4119	Cytochrome P450 2D6	CYP2D6	0.1771
587	Serum albumin	ALB	0.1622
4200	Cytochrome P450 1A2	CYP1A2	0.1539
6142	Solute carrier family 22 member 8	SLC22A8	0.1194
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.1179
633	Penicillin-binding proteins 1A/1B	pbpA	0.1172
4118	Cytochrome P450 3A5	CYP3A5	0.1156
118	Organic cation/carnitine transporter 2	SLC22A5	0.1106
6030	Cytochrome P450 2B6	CYP2B6	0.0921
6013	Cytochrome P450 2E1	CYP2E1	0.0836
6107	Cytochrome P450 3A7	CYP3A7	0.082
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0793
1024	Solute carrier family 22 member 11	SLC22A11	0.0785
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0724
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0704
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0677
6143	Solute carrier family 22 member 7	SLC22A7	0.0645
6024	Cytochrome P450 1A1	CYP1A1	0.0605
5718	Cytochrome P450 2A6	CYP2A6	0.0601
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0591
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0574
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.056
6106	Cytochrome P450 2C18	CYP2C18	0.0552
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0547
645	Penicillin-binding protein 1A	mrcA	0.0513
5805	Penicillin-binding protein 1A	ponA	0.0513
6185	Penicillin-binding protein 1A	mrcA	0.0513
6799	Penicillin-binding protein 1A	pbpA	0.0513
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0512
1	Peptidoglycan synthetase ftsI	ftsI	0.0481
4155	Peptidoglycan synthetase ftsI	ftsI	0.0481
2164	Multidrug resistance-associated protein 4	ABCC4	0.0479
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0471
862	Multidrug resistance-associated protein 1	ABCC1	0.046
1757	Myeloperoxidase	MPO	0.0427
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0407
543	Penicillin-binding protein 1B	mrcB	0.0385
6186	Penicillin-binding protein 1B	ponB	0.0385
6822	Penicillin-binding protein 1b	pbp1b	0.0385
6844	Penicillin-binding protein 1b	pbp1b	0.0385
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0384
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0383
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0381
1385	Angiotensin-converting enzyme 2	ACE2	0.0376
3923	Cholinesterase	BCHE	0.0364
738	Monocarboxylate transporter 1	SLC16A1	0.0335
776	Bile salt export pump	ABCB11	0.0325
275	Arachidonate 5-lipoxygenase	ALOX5	0.0323
492	Histamine H1 receptor	HRH1	0.0319
6145	Solute carrier family 22 member 1	SLC22A1	0.0318
183	Vascular endothelial growth factor A	VEGFA	0.031
6144	Solute carrier family 22 member 2	SLC22A2	0.0293
4604	Liver carboxylesterase 1	CES1	0.0278
824	Sodium-dependent serotonin transporter	SLC6A4	0.0277
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0252
556	Alpha-1A adrenergic receptor	ADRA1A	0.0252
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0252
234	Plasminogen	PLG	0.0246
115	Penicillin-binding protein 2	mrdA	0.0235
6069	Penicillin-binding protein 2	mrdA	0.0235
6118	Penicillin-binding protein 2	penA	0.0235
6187	Penicillin-binding protein 2	pbpA	0.0235
6686	Penicillin-binding protein 2	pbp2	0.0235
6939	Penicillin-binding protein 2	mrdA	0.0235
7163	Penicillin-binding protein 2	pbpA	0.0235
6067	Penicillin binding protein 2a	mecA	0.0233
56	Delta-aminolevulinic acid dehydratase	ALAD	0.023
2356	Delta-aminolevulinic acid dehydratase	hemB	0.023
3613	Delta-aminolevulinic acid dehydratase	hemB	0.023
3674	Delta-aminolevulinic acid dehydratase	hemB	0.023
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.022
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0217
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0208
831	D(2) dopamine receptor	DRD2	0.0206
3811	Cytochrome P450 19A1	CYP19A1	0.0203
338	DNA polymerase	UL30	0.0203
379	DNA polymerase	UL54	0.0203
697	DNA polymerase	ORF28	0.0203
2482	DNA polymerase	43	0.0203
4104	DNA polymerase	BALF5	0.0203
592	Carbonic anhydrase 4	CA4	0.0199
2544	Bacterial leucyl aminopeptidase	Not Available	0.0198
1898	Cytochrome P450 1B1	CYP1B1	0.0193
260	Cytochrome P450 51	ERG11	0.019
761	Cytochrome P450 51	ERG11	0.019
3163	Cytochrome P450 51	cyp51	0.019
6012	Tryptophan 2,3-dioxygenase	TDO2	0.019
632	Alpha-1B adrenergic receptor	ADRA1B	0.0188
295	Carbonic anhydrase 1	CA1	0.0183
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0181
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0179
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0178
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0178
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0177
70	Type-1 angiotensin II receptor	AGTR1	0.0175
136	Estrogen receptor	ESR1	0.0175
404	DNA gyrase subunit A	gyrA	0.0174
6224	DNA gyrase subunit A	gyrA	0.0174
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0173
318	Alpha-2A adrenergic receptor	ADRA2A	0.0173
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0173
731	HIV-1 protease	HIV-1 protease	0.0172
817	DNA topoisomerase 2-alpha	TOP2A	0.0169
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0169
833	Organic cation/carnitine transporter 1	SLC22A4	0.0169
766	Beta-2 adrenergic receptor	ADRB2	0.0169
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0167
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0167
373	Transthyretin	TTR	0.0166
357	Carbonic anhydrase 2	CA2	0.0159
3941	Amine oxidase [flavin-containing] A	MAOA	0.0157
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0156
3810	Catechol O-methyltransferase	COMT	0.0156
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0155
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0151
159	Penicillin-binding protein 2B	penA	0.0151
6121	Penicillin-binding protein 2B	penA	0.0151
193	Beta-1 adrenergic receptor	ADRB1	0.0149
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0149
122	P2Y purinoceptor 12	P2RY12	0.0149
3060	Leukotriene A-4 hydrolase	LTA4H	0.0149
146	Androgen receptor	AR	0.0148
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0146
4252	Penicillin-binding protein 5	dacA	0.0146
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0142
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0139
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0139
891	Dihydropteroate synthase	folP	0.0138
5359	Dihydropteroate synthase	folP	0.0138
7175	Dihydropteroate synthase	sulI	0.0138
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0138
23	D(1A) dopamine receptor	DRD1	0.0136
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0135
6136	Multidrug resistance-associated protein 5	ABCC5	0.0131
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0131
617	Muscarinic acetylcholine receptor M2	CHRM2	0.013
713	Sodium-dependent dopamine transporter	SLC6A3	0.0129
1507	Cytochrome c	CYCS	0.0128
6141	Sodium/bile acid cotransporter	SLC10A1	0.0126
558	Solute carrier family 12 member 1	SLC12A1	0.0126
509	Thymidine kinase	TK	0.0126
570	Thymidine kinase	TK	0.0126
2559	Thymidine kinase	TK	0.0126
3430	Thymidine kinase	tdk	0.0126
3518	Thymidine kinase	TK	0.0126
5301	Thymidine kinase	tdk	0.0126
5771	Thymidine kinase	ORF36	0.0126
7009	Thymidine kinase	ORF36	0.0126
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0125
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0125
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0123
3426	Glutamine synthetase	glnA	0.0123
3987	Glutamine synthetase	GLUL	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
3639	Thymidine phosphorylase	deoA	0.0122
3936	Thymidine phosphorylase	TYMP	0.0122
6126	Carbonic anhydrase 7	CA7	0.0121
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0121
3939	Amine oxidase [flavin-containing] B	MAOB	0.012
6147	Solute carrier family 22 member 3	SLC22A3	0.0119
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0119
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0119
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0118
6137	Multidrug resistance-associated protein 6	ABCC6	0.0118
6148	Multidrug resistance-associated protein 7	ABCC10	0.0116
723	Cytosolic phospholipase A2	PLA2G4A	0.0116
871	Glucocorticoid receptor	NR3C1	0.0113
847	Mu-type opioid receptor	OPRM1	0.0113
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0112
467	Delta-type opioid receptor	OPRD1	0.0111
696	Kappa-type opioid receptor	OPRK1	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0107
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0107
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0107
6182	Cytochrome P450 2J2	CYP2J2	0.0107
3760	Penicillin-binding protein 5 precursor	dacA	0.0105
789	Alpha-1D adrenergic receptor	ADRA1D	0.0105
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0105
867	Penicillin-binding protein 3	pbpC	0.0102
6119	Penicillin-binding protein 3	pbp3	0.0102
7154	Penicillin-binding protein 3	pbp3	0.0102
7157	Penicillin-binding protein 3	LMHCC_2184	0.0102
7162	Penicillin-binding protein 3	pbpB	0.0102
7172	Penicillin-binding protein 3	pbp3	0.0102
124	Histamine H2 receptor	HRH2	0.0102
6031	Cytochrome P450 3A43	CYP3A43	0.0102
6102	Arylamine N-acetyltransferase 2	NAT2	0.0102
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0101
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.01
477	DNA topoisomerase 4 subunit A	parC	0.0099
886	DNA topoisomerase 4 subunit A	parC	0.0099
6226	DNA topoisomerase 4 subunit A	parC	0.0099
465	Calmodulin	CALM1	0.0099
468	Cytochrome P450 4A11	CYP4A11	0.0098
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0098
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0097
6085	Fatty acid-binding protein, intestinal	FABP2	0.0097
65	Matrix metalloproteinase-9	Not Available	0.0095
811	Translocator protein	TSPO	0.0094
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0094
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0094
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0094
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0093
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0092
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0092
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0091
1192	Sulfotransferase 1A1	SULT1A1	0.0091
777	Tumor necrosis factor	TNF	0.0091
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
130	Prostacyclin synthase	PTGIS	0.009
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0089
24	Thymidylate synthase	TMP1	0.0088
359	Thymidylate synthase	TYMS	0.0088
2626	Thymidylate synthase	thyA	0.0088
2729	Thymidylate synthase	thyA	0.0088
5352	Thymidylate synthase	THYA	0.0088
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0088
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0087
844	Epidermal growth factor receptor	EGFR	0.0086
638	D(3) dopamine receptor	DRD3	0.0086
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0086
3312	Fatty acid-binding protein, brain	FABP7	0.0086
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0085
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0085
707	72 kDa type IV collagenase	MMP2	0.0085
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0084
6113	MecA PBP2' (penicillin binding protein 2')	mecA	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0081
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.008
6149	Solute carrier family 22 member 10	SLC22A10	0.008
427	Substance-P receptor	TACR1	0.0079
380	Cytochrome P450 17A1	CYP17A1	0.0079
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0077
4120	NADPH--cytochrome P450 reductase	POR	0.0077
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0077
2320	Thymidine kinase, cytosolic	TK1	0.0076
6014	Cytochrome P450 2A13	CYP2A13	0.0075
504	Mast/stem cell growth factor receptor	KIT	0.0075
6043	Putative G-protein coupled receptor 44	GPR44	0.0072
22	30S ribosomal protein S4	rpsD	0.0072
6714	30S ribosomal protein S4	rpsD	0.0072
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0072
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
185	Vasopressin V1a receptor	AVPR1A	0.0071
49	Endothelin B receptor	EDNRB	0.007
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.007
322	Vasopressin V2 receptor	AVPR2	0.0069
614	Progesterone receptor	PGR	0.0069
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0069
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0068
140	30S ribosomal protein S9	rpsI	0.0068
6719	30S ribosomal protein S9	rpsI	0.0068
6725	30S ribosomal protein S9	rpsI	0.0068
1141	Sialidase-1	NEU1	0.0068
64	Neuraminidase	NA	0.0068
641	Neuraminidase	NA	0.0068
2676	Neuraminidase	NA	0.0068
3026	Neuraminidase	NA	0.0068
3519	Neuraminidase	NA	0.0068
6007	Neuraminidase	NA	0.0068
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0067
161	Tubulin beta chain	TUBB	0.0067
312	Tubulin beta chain	TUB2	0.0067
527	Prostacyclin receptor	PTGIR	0.0066
578	Endothelin-1 receptor	EDNRA	0.0066
869	Estrogen receptor beta	ESR2	0.0066
5626	Nucleoside diphosphate kinase B	NME2	0.0065
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0065
407	Vascular endothelial growth factor receptor 2	KDR	0.0064
459	Retinoic acid receptor RXR-alpha	RXRA	0.0064
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0064
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0064
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0064
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0063
756	Sex hormone-binding globulin	SHBG	0.0062
4116	Dihydropteroate synthetase	Not Available	0.0062
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0061
1275	Estrogen sulfotransferase	SULT1E1	0.0061
432	D(4) dopamine receptor	DRD4	0.0061
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0061
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.006
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.006
26	Vascular endothelial growth factor receptor 3	FLT4	0.0059
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0059
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0059
365	Dihydrofolate reductase	DHFR	0.0059
2381	Dihydrofolate reductase	DFR1	0.0059
2833	Dihydrofolate reductase	Not Available	0.0059
2931	Dihydrofolate reductase	folA	0.0059
3544	Dihydrofolate reductase	folA	0.0059
3682	Dihydrofolate reductase	folA	0.0059
6642	Dihydrofolate reductase	folA	0.0059
6756	Dihydrofolate reductase	dfrA	0.0059
362	Melatonin receptor type 1B	MTNR1B	0.0058
571	Melatonin receptor type 1A	MTNR1A	0.0058
106	Cannabinoid receptor 2	CNR2	0.0058
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0058
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0058
6131	Carbonic anhydrase 14	CA14	0.0058
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0058
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0058
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0057
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0057
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0057
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0057
716	5-hydroxytryptamine 7 receptor	HTR7	0.0057
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0057
629	Alpha-2B adrenergic receptor	ADRA2B	0.0057
32	Vascular endothelial growth factor receptor 1	FLT1	0.0057
823	Fibroblast growth factor receptor 2	FGFR2	0.0057
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0057
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0056
703	NADPH azoreductase	azr	0.0056
7	Nitric oxide synthase, inducible	NOS2	0.0056
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0056
6033	High affinity interleukin-8 receptor A	CXCR1	0.0056
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0055
68	Cannabinoid receptor 1	CNR1	0.0055
4103	Proteasome subunit beta type 2	PSMB2	0.0055
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0055
4102	Proteasome subunit beta type 5	PSMB5	0.0055
4101	Proteasome subunit beta type 1	PSMB1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0054
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0054
1656	CYP2B protein	CYP2B	0.0054
850	Vasopressin V1b receptor	AVPR1B	0.0053
5294	Nucleoside diphosphate kinase A	NME1	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0053
340	Apoptotic protease-activating factor 1	APAF1	0.0052
634	Squalene monooxygenase	SQLE	0.0052
7196	Squalene monooxygenase	ERG1	0.0052
5482	Sialidase-2	NEU2	0.0052
438	Taste receptor type 1 member 2	TAS1R2	0.0051
474	Acetylcholinesterase	ACHE	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0051
1648	Elastin	ELN	0.005
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.005
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.005
1353	DNA topoisomerase 1	TOP1	0.005
3552	DNA topoisomerase 1	topA	0.005
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0049
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
1714	Mitogen-activated protein kinase 3	MAPK3	0.0049
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0049
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0049
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0048
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0048
1629	Transcription factor AP-1	JUN	0.0048
921	Glutamate receptor 2	GRIA2	0.0048
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0048
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0047
825	Arsenical pump-driving ATPase	ASNA1	0.0047
3435	Arsenical pump-driving ATPase	arsA	0.0047
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0047
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0047
733	Activin receptor type 1B	ACVR1B	0.0047
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0047
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0047
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0047
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0047
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0047
154	AFG3-like protein 2	AFG3L2	0.0047
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0047
395	ALK tyrosine kinase receptor	Not Available	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
163	D(1B) dopamine receptor	DRD5	0.0047
4773	Deoxycytidine kinase	DCK	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
1618	High affinity nerve growth factor receptor	NTRK1	0.0045
1650	Heme carrier protein 1	SLC46A1	0.0045
1010	Cytochrome P450 51A1	CYP51A1	0.0045
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0045
1196	Complement decay-accelerating factor	CD55	0.0045
952	Dipeptidyl peptidase 4	DPP4	0.0044
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0044
6220	Aryl hydrocarbon receptor	AHR	0.0043
484	Tyrosine-protein kinase ABL2	ABL2	0.0043
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0043
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
273	Apoptosis regulator Bcl-2	BCL2	0.0042
489	Monocarboxylate transporter 2	SLC16A7	0.0042
3932	Glutathione S-transferase A2	GSTA2	0.0042
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0042
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0042
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0042
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0042
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
2021	Thrombomodulin	THBD	0.0041
408	Riboflavin kinase	RFK	0.0041
292	Activin receptor type-1	ACVR1	0.0041
849	Activated CDC42 kinase 1	TNK2	0.0041
6103	Arylamine N-acetyltransferase 1	NAT1	0.0041
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.004
297	Adenylate cyclase type 1	ADCY1	0.004
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.004
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.004
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.004
319	Opioid receptor, sigma 1	OPRS1	0.004
818	50S ribosomal protein L10	rplJ	0.0039
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0039
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0039
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0039
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0039
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
33	Cystine/glutamate transporter	SLC7A11	0.0039
2808	Chloramphenicol acetyltransferase 3	cat3	0.0039
737	Mineralocorticoid receptor	NR3C2	0.0039
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0038
2539	Tubulin alpha-1 chain	TUBA4A	0.0038
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0038
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0038
6138	Multidrug resistance protein 3	ABCB4	0.0038
3808	Dihydropteroate synthase 2	folP2	0.0037
3601	Dihydropteroate synthase 1	folP1	0.0037
3807	Dihydropteroate synthase 1	folP1	0.0037
5353	Glutamate decarboxylase alpha	gadA	0.0037
29	Tubulin beta-1 chain	TUBB1	0.0037
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0037
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0037
5300	Antigen peptide transporter 1	TAP1	0.0037
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0037
6122	Carbonic anhydrase 3	CA3	0.0037
378	Alpha-2C adrenergic receptor	ADRA2C	0.0036
3007	Carbonic anhydrase 12	CA12	0.0036
4205	Carbonic anhydrase 9	CA9	0.0036
6146	High affinity copper uptake protein 1	SLC31A1	0.0036
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0036
2417	Chloramphenicol acetyltransferase	cat	0.0036
3278	Chloramphenicol acetyltransferase	cat	0.0036
6167	Organic solute transporter subunit beta	OSTB	0.0035
6166	Organic solute transporter subunit alpha	OSTA	0.0035
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
4217	Telomerase reverse transcriptase	TERT	0.0035
2449	Tubulin alpha-3 chain	TUBA1A	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0035
54	Prothrombin	F2	0.0035
740	Argininosuccinate synthase	ASS1	0.0035
865	Argininosuccinate synthase	ASS1	0.0035
2680	Argininosuccinate synthase	argG	0.0035
3194	Argininosuccinate synthase	argG	0.0035
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0035
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0035
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0034
6174	50S ribosomal protein L32	rpmF	0.0034
3947	Xanthine dehydrogenase/oxidase	XDH	0.0033
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
239	Coagulation factor X	F10	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
6021	Adenosine kinase	ADK	0.0033
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0032
661	ADP/ATP translocase 1	SLC25A4	0.0032
904	Glutathione S-transferase P	GSTP1	0.0032
2499	Tubulin beta-2C chain	TUBB2C	0.0031
4203	Histamine N-methyltransferase	HNMT	0.0031
94	5-hydroxytryptamine 4 receptor	HTR4	0.0031
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
482	Glycine receptor subunit alpha-1	GLRA1	0.0031
1852	Microtubule-associated protein 2	MAP2	0.003
6042	Prostaglandin reductase 2	PTGR2	0.003
1039	Histone deacetylase 9	HDAC9	0.003
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.003
1050	Bile salt sulfotransferase	SULT2A1	0.003
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.003
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0029
654	Flavin reductase	BLVRB	0.0029
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
293	Gamma-glutamyl hydrolase	GGH	0.0029
822	Aldose reductase	AKR1B1	0.0029
780	Retinoic acid receptor RXR-gamma	RXRG	0.0029
6432	Transporter	snf	0.0029
6500	Phospholipase A2	PLA2G1B	0.0029
683	Potassium transporter	GK0582	0.0029
1374	Natriuretic peptides B	NPPB	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
1827	Gap junction alpha-1 protein	GJA1	0.0029
1908	Vascular cell adhesion protein 1	VCAM1	0.0029
1792	Tissue-type plasminogen activator	PLAT	0.0029
6151	Monocarboxylate transporter 10	SLC16A10	0.0028
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
1867	Major prion protein	PRNP	0.0028
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0028
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0028
1864	RET proto-oncogene	RET	0.0028
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0027
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0027
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0027
1025	Aquaporin-1	AQP1	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
4237	50S ribosomal protein L22	rplV	0.0027
702	UMP-CMP kinase	CMPK1	0.0027
518	Peroxidase/catalase T	katG	0.0027
3685	Catabolite gene activator	crp	0.0027
4655	Adenylate cyclase	cyaC	0.0027
4759	Adenylate cyclase	cyaB2	0.0027
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0026
88	Retinoic acid receptor RXR-beta	RXRB	0.0026
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0026
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0026
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0026
153	Dopamine beta-hydroxylase	DBH	0.0026
992	Protein tyrosine kinase 2 beta	PTK2B	0.0026
85	Growth hormone receptor	GHR	0.0025
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0025
2236	Casein kinase II subunit alpha	CSNK2A1	0.0025
2207	Rhodopsin	RHO	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
1541	Metalloproteinase	mmp20	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0024
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0024
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0024
6207	30S ribosomal protein S14	rpsN	0.0024
6209	30S ribosomal protein S19	rpsS	0.0024
6712	30S ribosomal protein S19	rpsS	0.0024
6726	30S ribosomal protein S19	rpsS	0.0024
759	Free fatty acid receptor 1	FFAR1	0.0024
6218	Pannexin-1	PANX1	0.0024
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0024
1178	Adenosine A2a receptor	ADORA2A	0.0024
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
3809	Estrogen-related receptor gamma	ESRRG	0.0024
3611	Cytidine deaminase	cdd	0.0024
3707	Cytidine deaminase	cdd	0.0024
4211	Cytidine deaminase	CDA	0.0024
165	FL cytokine receptor	FLT3	0.0024
1313	Lactoylglutathione lyase	GLO1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0023
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0023
4760	Mll3241 protein	mll3241	0.0023
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0022
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0022
563	Thyroid peroxidase	TPO	0.0022
976	Platelet glycoprotein IX	GP9	0.0022
1630	Integrin beta-2	ITGB2	0.0022
1517	Beta-3 adrenergic receptor	ADRB3	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0022
908	Glutathione S-transferase theta-1	GSTT1	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0021
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
1053	BC269730_2	FADS1	0.0021
1395	Sodium/calcium exchanger 1	SLC8A1	0.0021
1198	Serum paraoxonase/arylesterase 1	PON1	0.0021
6223	Penicillin-binding protein 1C	pbpC	0.0021
672	Prostaglandin F2-alpha receptor	PTGFR	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
4122	Histone deacetylase 2	HDAC2	0.002
4192	DNA topoisomerase 2-beta	TOP2B	0.002
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.002
5251	Carbonyl reductase [NADPH] 1	CBR1	0.002
1256	5-hydroxytryptamine 6 receptor	HTR6	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
174	Sigma 1-type opioid receptor	SIGMAR1	0.0019
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0019
469	Annexin A1	ANXA1	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
1253	Interferon gamma	IFNG	0.0018
936	Ephrin type-A receptor 2	EPHA2	0.0018
6044	Serum paraoxonase/lactonase 3	PON3	0.0018
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0018
605	Fumarate reductase flavoprotein subunit	frdA	0.0018
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0018
3673	Fumarate reductase flavoprotein subunit	fccA	0.0018
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0018
6549	Fumarate reductase flavoprotein subunit	frdA	0.0018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0018
4311	tRNA	TRDMT1	0.0018
4325	tRNA	trmD	0.0018
4328	tRNA	trmD	0.0018
53	Solute carrier family 12 member 5	SLC12A5	0.0018
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0018
663	Solute carrier family 12 member 4	SLC12A4	0.0018
84	Nuclear receptor 0B1	NR0B1	0.0018
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0017
581	Cytochrome P450 2R1	CYP2R1	0.0017
164	Histamine H4 receptor	HRH4	0.0017
5787	Angiopoietin-1 receptor	TEK	0.0017
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0017
1144	Hepatocyte growth factor receptor	MET	0.0017
594	Thyroxine-binding globulin	SERPINA7	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
768	FK506-binding protein 1A	FKBP1A	0.0017
3830	Calreticulin	CALR	0.0017
572	Integrin alpha-L	ITGAL	0.0017
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0017
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0017
310	Solute carrier family 12 member 2	SLC12A2	0.0017
5798	Mitogen-activated protein kinase 11	MAPK11	0.0017
1992	Vitamin D-binding protein	GC	0.0016
5923	Microtubule-associated protein tau	MAPT	0.0016
5924	Microtubule-associated protein 4	MAP4	0.0016
6824	Tyrosine-protein kinase Lyn	LYN	0.0016
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0016
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
2408	Tyrosine-protein kinase SYK	SYK	0.0016
2599	Tyrosine-protein kinase HCK	HCK	0.0016
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0016
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
758	Thyroid hormone receptor alpha	THRA	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
444	Alcohol dehydrogenase 1B	ADH1B	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0015
494	Caspase-1	CASP1	0.0015
6755	Poliovirus receptor	PVR	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0015
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0015
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0015
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0015
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0015
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0015
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0015
3587	Gastrotropin	FABP6	0.0015
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0015
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0015
16	Adenosine A1 receptor	ADORA1	0.0015
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
5934	Cytochrome P450 26A1	CYP26A1	0.0015
1405	Thiopurine S-methyltransferase	TPMT	0.0015
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
346	Thyroid hormone receptor beta-1	THRB	0.0014
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0014
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0014
251	Alcohol dehydrogenase 1A	ADH1A	0.0014
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
2232	Interleukin-5	IL5	0.0014
1593	Mucin-2	MUC2	0.0014
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0013
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0013
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0013
3957	Adenosine deaminase	ADA	0.0013
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0013
820	Glycine receptor subunit alpha-2	GLRA2	0.0013
2077	Caspase-3	CASP3	0.0013
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0013
814	Ryanodine receptor 1	RYR1	0.0013
517	Alcohol dehydrogenase 1C	ADH1C	0.0013
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
819	Penicillin-binding protein 4	dacB	0.0012
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
3856	Fibroblast growth factor receptor 3	FGFR3	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
3221	Cytochrome c4	cc4	0.0012
5818	Folate receptor alpha	FOLR1	0.0012
694	Matrix protein 2	M	0.0012
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0012
856	Vitamin D3 receptor	VDR	0.0012
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0012
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0012
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0012
461	Glycine receptor subunit alpha-3	GLRA3	0.0012
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0012
6859	Protein S100-A4	S100A4	0.0012
6048	Troponin C, skeletal muscle	TNNC2	0.0012
291	Nitric-oxide synthase, endothelial	NOS3	0.0011
267	Plasminogen activator inhibitor 1	SERPINE1	0.0011
2112	Toll-like receptor 9	TLR9	0.0011
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0011
284	DNA-directed RNA polymerase beta chain	rpoB	0.0011
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0011
1123	Eosinophil cationic protein	RNASE3	0.0011
162	Retinoic acid receptor gamma-1	RARG	0.0011
6459	Glycodelin	PAEP	0.0011
232	Corticosteroid-binding globulin	SERPINA6	0.0011
131	Synaptic vesicular amine transporter	SLC18A2	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
997	Protein kinase C beta type	PRKCB	0.001
6221	Steroid hormone receptor ERR1	ESRRA	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
6020	Aldehyde oxidase	AOX1	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
890	Niemann-Pick C1-like protein 1	NPC1L1	0.001
199	Monocarboxylate transporter 8	SLC16A2	0.001
3913	Glutamic acid decarboxylase	GAD65	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0009
3937	Fatty-acid amide hydrolase	FAAH	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
1291	cAMP response element-binding protein	CREB1	0.0009
1341	Histamine H3 receptor	HRH3	0.0009
1525	Heparin-binding growth factor 2	FGF2	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1569	G1/S-specific cyclin-D1	CCND1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
4210	Toll-like receptor 4	TLR4	0.0009
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0009
1483	Membrane copper amine oxidase	AOC3	0.0009
751	Potassium channel subfamily K member 6	KCNK6	0.0009
1760	Aminopeptidase N	ANPEP	0.0009
6843	Aminopeptidase N	pepN	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
117	Sterol O-acyltransferase 1	SOAT1	0.0008
1184	Interferon beta	IFNB1	0.0008
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0008
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0008
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0008
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0008
6211	Tubulin epsilon chain	TUBE1	0.0008
6212	Tubulin gamma-1 chain	TUBG1	0.0008
6210	Tubulin delta chain	TUBD1	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
735	Alanine aminotransferase 1	GPT	0.0008
3904	Alanine aminotransferase 2	GPT2	0.0008
172	Potassium channel subfamily K member 1	KCNK1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
6163	Copper-transporting ATPase 2	ATP7B	0.0008
6165	Copper-transporting ATPase 1	ATP7A	0.0008
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0008
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0007
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0007
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0007
76	Nitric-oxide synthase, brain	NOS1	0.0007
4692	A/G-specific adenine glycosylase	mutY	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
896	Glutathione S-transferase Mu 1	GSTM1	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
2216	Fibroblast growth factor receptor 4	FGFR4	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
2802	Endoglucanase G	celCCG	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
1176	Mitogen-activated protein kinase 1	MAPK1	0.0006
4225	Uridine phosphorylase 1	UPP1	0.0006
705	Glutamate receptor 1	GRIA1	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
719	Retinoic acid receptor responder protein 1	RARRES1	0.0006
770	Retinoic acid-induced protein 3	GPRC5A	0.0006
268	Adenosine A2b receptor	ADORA2B	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
828	Phenylalanine-4-hydroxylase	PAH	0.0006
3109	Phenylalanine-4-hydroxylase	phhA	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
2430	Chondroitinase B	cslB	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4916	Cyanoglobin	glbN	0.0005
4943	Cytochrome c6	petJ	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4984	Neuroglobin	NGB	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4909	CooA protein	cooA	0.0005
4961	Hemophore HasA	hasA	0.0005
5000	HemO	hemO	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4910	Cytoglobin	CYGB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4972	P450cin	cinA	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4952	Catalase/peroxidase	katA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
569	Retinal dehydrogenase 2	ALDH1A2	0.0005
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0005
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
611	Retinal dehydrogenase 1	ALDH1A1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0005
1268	Neuropeptide S receptor	NPSR1	0.0005
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0005
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
6133	Sodium channel subunit beta-2	SCN2B	0.0005
6134	Sodium channel subunit beta-3	SCN3B	0.0005
6129	Carbonic anhydrase-related protein 11	CA11	0.0005
6132	Sodium channel subunit beta-1	SCN1B	0.0005
6135	Sodium channel subunit beta-4	SCN4B	0.0005
6127	Carbonic anhydrase-related protein	CA8	0.0005
6128	Carbonic anhydrase-related protein 10	CA10	0.0005
760	Fibroblast growth factor 1	FGF1	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
6073	Potassium channel subfamily K member 9	KCNK9	0.0004
6072	Potassium channel subfamily K member 3	KCNK3	0.0004
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0004
6130	Carbonic anhydrase 13	CA13	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4990	PpcA	ppcA	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0004
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0004
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0004
6168	Solute carrier family 22 member 16	SLC22A16	0.0004
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
2298	Cytochrome P450-cam	camC	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00672 - Chlorpropamide

Targets

Enzymes

Transporters

Predictions