DT-Web

DB00812 - Phenylbutazone


Identification
Name Phenylbutazone
Accession Number DB00812 (APRD00409, DB08343)
Type small molecule
Description A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 308.3743
Groups approved
Monoisotopic Weight 308.152477894
Pharmacology
Indication For the treatment of backache and ankylosing spondylitis
Mechanism of action Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The NSAID, phenylbutazone, may increase the anticoagulant effect of acenocoumarol.
Acetohexamide Phenylbutazone may increase the effect of acetohexamide.
Anisindione The NSAID, phenylbutazone, may increase the anticoagulant effect of anisindione.
Chlorpropamide Phenylbutazone increases the effect of the hypoglycemic agent
Dicumarol The NSAID, phenylbutazone, may increase the anticoagulant effect of dicumarol.
Ethotoin The NSAID, phenylbutazone, may increase the hydantoin effect of ethotoin.
Fosphenytoin The NSAID, phenylbutazone, may increase the hydantoin effect of fosphenytoin.
Gliclazide Phenylbutazone increases the effect of the hypoglycemic agent
Glipizide Phenylbutazone increases the effect of the hypoglycemic agent
Glisoxepide Phenylbutazone increases the effect of the hypoglycemic agent
Glyburide Phenylbutazone increases the effect of the hypoglycemic agent
Glycodiazine Phenylbutazone increases the effect of the hypoglycemic agent
Lithium The NSAID, phenylbutazone, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.
Mephenytoin The NSAID, phenylbutazone, may increase the hydantoin effect of mephenytoin.
Methotrexate The NSAID, phenylbutazone, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Phenytoin The NSAID, phenylbutazone, may increase the therapeutic and adverse effects of phenytoin.
Tolazamide Phenylbutazone increases the effect of the hypoglycemic agent
Tolbutamide Phenylbutazone increases the effect of the hypoglycemic agent
Warfarin The NSAID, phenylbutazone, may increase the anticoagulant effect of warfarin.
Food Interactions
  • Take with food to reduce irritation. Avoid alcohol.

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Arifah AK, Lees P: Pharmacodynamics and pharmacokinetics of phenylbutazone in calves. J Vet Pharmacol Ther. 2002 Aug;25(4):299-309. - Pubmed
  • Takada Y, Bhardwaj A, Potdar P, Aggarwal BB: Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9;23(57):9247-58. - Pubmed
  • Beretta C, Garavaglia G, Cavalli M: COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6032
Prostacyclin synthase
Name Prostacyclin synthase
Gene Name PTGIS
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Reed GA, Griffin IO, Eling TE: Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolism. Mol Pharmacol. 1985 Jan;27(1):109-14. - Pubmed
  • Marnett LJ, Siedlik PH, Ochs RC, Pagels WR, Das M, Honn KV, Warnock RH, Tainer BE, Eling TE: Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom. Mol Pharmacol. 1984 Sep;26(2):328-35. - Pubmed
  • Tobin T, Chay S, Kamerling S, Woods WE, Weckman TJ, Blake JW, Lees P: Phenylbutazone in the horse: a review. J Vet Pharmacol Ther. 1986 Mar;9(1):1-25. - Pubmed
DTHybrid score 0.7574
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action yes
Actions inhibitor
References
  • Zitova A, Hynes J, Kollar J, Borisov SM, Klimant I, Papkovsky DB: Analysis of activity and inhibition of oxygen-dependent enzymes by optical respirometry on the LightCycler system. Anal Biochem. 2010 Feb 15;397(2):144-51. Epub 2009 Oct 20. - Pubmed
  • Beretta C, Garavaglia G, Cavalli M: COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol Res. 2005 Oct;52(4):302-6. - Pubmed
  • Morton AJ, Campbell NB, Gayle JM, Redding WR, Blikslager AT: Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis. Res Vet Sci. 2005 Apr;78(2):189-92. - Pubmed
DTHybrid score 0.6628

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4337
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4217

Transporters


Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
  • Uwai Y, Saito H, Inui K: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 2000 Dec 1;409(1):31-6. - Pubmed
  • Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score 0.482
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
DTHybrid score 0.3671
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions inhibitor
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. - Pubmed
DTHybrid score 0.2862

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.1781
4924 Cytochrome P450 2C8 CYP2C8 0.1758
587 Serum albumin ALB 0.1596
4200 Cytochrome P450 1A2 CYP1A2 0.1486
6143 Solute carrier family 22 member 7 SLC22A7 0.139
4119 Cytochrome P450 2D6 CYP2D6 0.138
1588 Multidrug resistance protein 1 ABCB1 0.1373
527 Prostacyclin receptor PTGIR 0.1099
4118 Cytochrome P450 3A5 CYP3A5 0.1014
122 P2Y purinoceptor 12 P2RY12 0.0958
6013 Cytochrome P450 2E1 CYP2E1 0.0814
2164 Multidrug resistance-associated protein 4 ABCC4 0.0784
6030 Cytochrome P450 2B6 CYP2B6 0.075
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0686
6107 Cytochrome P450 3A7 CYP3A7 0.0672
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0613
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0601
118 Organic cation/carnitine transporter 2 SLC22A5 0.0596
275 Arachidonate 5-lipoxygenase ALOX5 0.0593
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0589
6024 Cytochrome P450 1A1 CYP1A1 0.0581
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0557
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.053
5718 Cytochrome P450 2A6 CYP2A6 0.0522
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0502
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0494
862 Multidrug resistance-associated protein 1 ABCC1 0.0479
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0475
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0454
6144 Solute carrier family 22 member 2 SLC22A2 0.0432
6145 Solute carrier family 22 member 1 SLC22A1 0.041
1757 Myeloperoxidase MPO 0.0388
738 Monocarboxylate transporter 1 SLC16A1 0.0369
140 30S ribosomal protein S9 rpsI 0.0368
6719 30S ribosomal protein S9 rpsI 0.0368
6725 30S ribosomal protein S9 rpsI 0.0368
22 30S ribosomal protein S4 rpsD 0.0365
6714 30S ribosomal protein S4 rpsD 0.0365
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0365
6106 Cytochrome P450 2C18 CYP2C18 0.0358
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0344
776 Bile salt export pump ABCB11 0.0333
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0327
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0321
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0301
633 Penicillin-binding proteins 1A/1B pbpA 0.0297
3811 Cytochrome P450 19A1 CYP19A1 0.0292
373 Transthyretin TTR 0.0269
492 Histamine H1 receptor HRH1 0.0268
6141 Sodium/bile acid cotransporter SLC10A1 0.0263
833 Organic cation/carnitine transporter 1 SLC22A4 0.0261
6012 Tryptophan 2,3-dioxygenase TDO2 0.0251
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.025
645 Penicillin-binding protein 1A mrcA 0.0249
5805 Penicillin-binding protein 1A ponA 0.0249
6185 Penicillin-binding protein 1A mrcA 0.0249
6799 Penicillin-binding protein 1A pbpA 0.0249
438 Taste receptor type 1 member 2 TAS1R2 0.0248
6136 Multidrug resistance-associated protein 5 ABCC5 0.0245
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0245
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0238
558 Solute carrier family 12 member 1 SLC12A1 0.0234
672 Prostaglandin F2-alpha receptor PTGFR 0.0234
338 DNA polymerase UL30 0.0228
379 DNA polymerase UL54 0.0228
697 DNA polymerase ORF28 0.0228
2482 DNA polymerase 43 0.0228
4104 DNA polymerase BALF5 0.0228
592 Carbonic anhydrase 4 CA4 0.0225
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0224
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0223
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0222
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
136 Estrogen receptor ESR1 0.0221
543 Penicillin-binding protein 1B mrcB 0.0221
6186 Penicillin-binding protein 1B ponB 0.0221
6822 Penicillin-binding protein 1b pbp1b 0.0221
6844 Penicillin-binding protein 1b pbp1b 0.0221
357 Carbonic anhydrase 2 CA2 0.022
295 Carbonic anhydrase 1 CA1 0.0213
6149 Solute carrier family 22 member 10 SLC22A10 0.0212
3923 Cholinesterase BCHE 0.021
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
146 Androgen receptor AR 0.02
871 Glucocorticoid receptor NR3C1 0.0199
3312 Fatty acid-binding protein, brain FABP7 0.0199
2016 Dipeptidase 1 DPEP1 0.0197
723 Cytosolic phospholipase A2 PLA2G4A 0.0194
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0191
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0188
3947 Xanthine dehydrogenase/oxidase XDH 0.0188
1507 Cytochrome c CYCS 0.0187
1898 Cytochrome P450 1B1 CYP1B1 0.0187
1159 Interleukin-6 IL6 0.0185
6147 Solute carrier family 22 member 3 SLC22A3 0.0185
5353 Glutamate decarboxylase alpha gadA 0.0183
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0183
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0181
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.018
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0179
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0179
6033 High affinity interleukin-8 receptor A CXCR1 0.017
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.017
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0169
6043 Putative G-protein coupled receptor 44 GPR44 0.0166
6148 Multidrug resistance-associated protein 7 ABCC10 0.0166
824 Sodium-dependent serotonin transporter SLC6A4 0.0165
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0163
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
777 Tumor necrosis factor TNF 0.0158
404 DNA gyrase subunit A gyrA 0.0158
6224 DNA gyrase subunit A gyrA 0.0158
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0157
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0154
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0153
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0152
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
6137 Multidrug resistance-associated protein 6 ABCC6 0.0149
70 Type-1 angiotensin II receptor AGTR1 0.0147
1867 Major prion protein PRNP 0.0147
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0146
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0146
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0146
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0145
502 5-hydroxytryptamine 2A receptor HTR2A 0.0144
185 Vasopressin V1a receptor AVPR1A 0.0142
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0142
6126 Carbonic anhydrase 7 CA7 0.0141
322 Vasopressin V2 receptor AVPR2 0.014
731 HIV-1 protease HIV-1 protease 0.014
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0139
115 Penicillin-binding protein 2 mrdA 0.0138
6069 Penicillin-binding protein 2 mrdA 0.0138
6118 Penicillin-binding protein 2 penA 0.0138
6187 Penicillin-binding protein 2 pbpA 0.0138
6686 Penicillin-binding protein 2 pbp2 0.0138
6939 Penicillin-binding protein 2 mrdA 0.0138
7163 Penicillin-binding protein 2 pbpA 0.0138
6085 Fatty acid-binding protein, intestinal FABP2 0.0138
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0137
124 Histamine H2 receptor HRH2 0.0137
6220 Aryl hydrocarbon receptor AHR 0.0135
556 Alpha-1A adrenergic receptor ADRA1A 0.0135
4604 Liver carboxylesterase 1 CES1 0.0135
891 Dihydropteroate synthase folP 0.0134
5359 Dihydropteroate synthase folP 0.0134
7175 Dihydropteroate synthase sulI 0.0134
847 Mu-type opioid receptor OPRM1 0.0133
6020 Aldehyde oxidase AOX1 0.0132
703 NADPH azoreductase azr 0.0132
6102 Arylamine N-acetyltransferase 2 NAT2 0.0131
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.013
1 Peptidoglycan synthetase ftsI ftsI 0.0129
4155 Peptidoglycan synthetase ftsI ftsI 0.0129
831 D(2) dopamine receptor DRD2 0.0128
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0128
6207 30S ribosomal protein S14 rpsN 0.0127
6209 30S ribosomal protein S19 rpsS 0.0127
6712 30S ribosomal protein S19 rpsS 0.0127
6726 30S ribosomal protein S19 rpsS 0.0127
5626 Nucleoside diphosphate kinase B NME2 0.0127
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0127
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0126
260 Cytochrome P450 51 ERG11 0.0125
761 Cytochrome P450 51 ERG11 0.0125
3163 Cytochrome P450 51 cyp51 0.0125
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0124
817 DNA topoisomerase 2-alpha TOP2A 0.0124
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
850 Vasopressin V1b receptor AVPR1B 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
3639 Thymidine phosphorylase deoA 0.0122
3936 Thymidine phosphorylase TYMP 0.0122
220 Sodium channel protein type 5 subunit alpha SCN5A 0.012
232 Corticosteroid-binding globulin SERPINA6 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
183 Vascular endothelial growth factor A VEGFA 0.0119
467 Delta-type opioid receptor OPRD1 0.0118
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0117
6167 Organic solute transporter subunit beta OSTB 0.0117
6166 Organic solute transporter subunit alpha OSTA 0.0117
614 Progesterone receptor PGR 0.0116
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
320 5-hydroxytryptamine 1A receptor HTR1A 0.0113
2249 Aspartate aminotransferase aspC 0.0112
2671 Aspartate aminotransferase aspC 0.0112
5490 Aspartate aminotransferase Not Available 0.0112
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0111
663 Solute carrier family 12 member 4 SLC12A4 0.0111
53 Solute carrier family 12 member 5 SLC12A5 0.0111
341 5-hydroxytryptamine 3 receptor HTR3A 0.0111
3426 Glutamine synthetase glnA 0.011
3987 Glutamine synthetase GLUL 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
318 Alpha-2A adrenergic receptor ADRA2A 0.0109
2320 Thymidine kinase, cytosolic TK1 0.0108
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0108
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0108
811 Translocator protein TSPO 0.0107
1648 Elastin ELN 0.0106
2981 Phospholipase A2, membrane associated PLA2G2A 0.0106
696 Kappa-type opioid receptor OPRK1 0.0105
310 Solute carrier family 12 member 2 SLC12A2 0.0104
5294 Nucleoside diphosphate kinase A NME1 0.0103
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
617 Muscarinic acetylcholine receptor M2 CHRM2 0.01
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0099
6031 Cytochrome P450 3A43 CYP3A43 0.0099
1439 Lactotransferrin LTF 0.0098
756 Sex hormone-binding globulin SHBG 0.0098
1405 Thiopurine S-methyltransferase TPMT 0.0097
867 Penicillin-binding protein 3 pbpC 0.0094
6119 Penicillin-binding protein 3 pbp3 0.0094
7154 Penicillin-binding protein 3 pbp3 0.0094
7157 Penicillin-binding protein 3 LMHCC_2184 0.0094
7162 Penicillin-binding protein 3 pbpB 0.0094
7172 Penicillin-binding protein 3 pbp3 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0093
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0093
590 5-hydroxytryptamine 2C receptor HTR2C 0.0093
1650 Heme carrier protein 1 SLC46A1 0.0093
24 Thymidylate synthase TMP1 0.0092
359 Thymidylate synthase TYMS 0.0092
2626 Thymidylate synthase thyA 0.0092
2729 Thymidylate synthase thyA 0.0092
5352 Thymidylate synthase THYA 0.0092
1654 Interleukin-1 beta IL1B 0.0092
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0092
3941 Amine oxidase [flavin-containing] A MAOA 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
713 Sodium-dependent dopamine transporter SLC6A3 0.009
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
6131 Carbonic anhydrase 14 CA14 0.009
2021 Thrombomodulin THBD 0.0089
459 Retinoic acid receptor RXR-alpha RXRA 0.0089
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0089
632 Alpha-1B adrenergic receptor ADRA1B 0.0089
489 Monocarboxylate transporter 2 SLC16A7 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
766 Beta-2 adrenergic receptor ADRB2 0.0086
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0084
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0083
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
6014 Cytochrome P450 2A13 CYP2A13 0.0083
23 D(1A) dopamine receptor DRD1 0.0083
477 DNA topoisomerase 4 subunit A parC 0.0083
886 DNA topoisomerase 4 subunit A parC 0.0083
6226 DNA topoisomerase 4 subunit A parC 0.0083
65 Matrix metalloproteinase-9 Not Available 0.0082
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0082
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0081
1656 CYP2B protein CYP2B 0.0081
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
3810 Catechol O-methyltransferase COMT 0.0079
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0078
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0078
4217 Telomerase reverse transcriptase TERT 0.0077
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0075
494 Caspase-1 CASP1 0.0075
1275 Estrogen sulfotransferase SULT1E1 0.0074
1714 Mitogen-activated protein kinase 3 MAPK3 0.0074
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0074
468 Cytochrome P450 4A11 CYP4A11 0.0074
952 Dipeptidyl peptidase 4 DPP4 0.0074
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0074
737 Mineralocorticoid receptor NR3C2 0.0074
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
3823 Cytokine receptor common gamma chain IL2RG 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
789 Alpha-1D adrenergic receptor ADRA1D 0.0072
273 Apoptosis regulator Bcl-2 BCL2 0.0071
2236 Casein kinase II subunit alpha CSNK2A1 0.0071
3917 Methylenetetrahydrofolate reductase MTHFR 0.0071
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.007
634 Squalene monooxygenase SQLE 0.007
7196 Squalene monooxygenase ERG1 0.007
49 Endothelin B receptor EDNRB 0.0069
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0069
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0069
68 Cannabinoid receptor 1 CNR1 0.0069
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0068
3760 Penicillin-binding protein 5 precursor dacA 0.0068
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0067
6042 Prostaglandin reductase 2 PTGR2 0.0066
885 5-hydroxytryptamine 1B receptor HTR1B 0.0066
6122 Carbonic anhydrase 3 CA3 0.0066
244 Angiotensin-converting enzyme ACE 0.0066
427 Substance-P receptor TACR1 0.0066
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
365 Dihydrofolate reductase DHFR 0.0065
2381 Dihydrofolate reductase DFR1 0.0065
2833 Dihydrofolate reductase Not Available 0.0065
2931 Dihydrofolate reductase folA 0.0065
3544 Dihydrofolate reductase folA 0.0065
3682 Dihydrofolate reductase folA 0.0065
6642 Dihydrofolate reductase folA 0.0065
6756 Dihydrofolate reductase dfrA 0.0065
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0065
823 Fibroblast growth factor receptor 2 FGFR2 0.0065
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0065
3685 Catabolite gene activator crp 0.0065
33 Cystine/glutamate transporter SLC7A11 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
661 ADP/ATP translocase 1 SLC25A4 0.0064
6500 Phospholipase A2 PLA2G1B 0.0064
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0064
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0064
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0063
724 Interleukin-2 receptor alpha chain IL2RA 0.0063
717 Interleukin-2 receptor subunit beta IL2RB 0.0063
2077 Caspase-3 CASP3 0.0063
133 Dihydropterate synthase sulI 0.0063
1792 Tissue-type plasminogen activator PLAT 0.0062
465 Calmodulin CALM1 0.0061
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0061
819 Penicillin-binding protein 4 dacB 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
629 Alpha-2B adrenergic receptor ADRA2B 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0059
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
6182 Cytochrome P450 2J2 CYP2J2 0.0059
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0059
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0059
725 5-hydroxytryptamine 1D receptor HTR1D 0.0059
818 50S ribosomal protein L10 rplJ 0.0058
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0058
869 Estrogen receptor beta ESR2 0.0058
828 Phenylalanine-4-hydroxylase PAH 0.0058
3109 Phenylalanine-4-hydroxylase phhA 0.0058
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
3808 Dihydropteroate synthase 2 folP2 0.0057
3601 Dihydropteroate synthase 1 folP1 0.0057
3807 Dihydropteroate synthase 1 folP1 0.0057
3007 Carbonic anhydrase 12 CA12 0.0057
4205 Carbonic anhydrase 9 CA9 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0056
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0056
3939 Amine oxidase [flavin-containing] B MAOB 0.0056
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0055
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0055
4760 Mll3241 protein mll3241 0.0055
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0055
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0055
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0055
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0055
571 Melatonin receptor type 1A MTNR1A 0.0055
362 Melatonin receptor type 1B MTNR1B 0.0055
293 Gamma-glutamyl hydrolase GGH 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
193 Beta-1 adrenergic receptor ADRB1 0.0053
6218 Pannexin-1 PANX1 0.0053
3932 Glutathione S-transferase A2 GSTA2 0.0053
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0053
436 5-hydroxytryptamine 2B receptor HTR2B 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
1192 Sulfotransferase 1A1 SULT1A1 0.0052
29 Tubulin beta-1 chain TUBB1 0.0052
638 D(3) dopamine receptor DRD3 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
1313 Lactoylglutathione lyase GLO1 0.0051
716 5-hydroxytryptamine 7 receptor HTR7 0.0051
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0051
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0051
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0051
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0051
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.005
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.005
7 Nitric oxide synthase, inducible NOS2 0.0049
822 Aldose reductase AKR1B1 0.0049
1629 Transcription factor AP-1 JUN 0.0049
1053 BC269730_2 FADS1 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
504 Mast/stem cell growth factor receptor KIT 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0048
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0048
378 Alpha-2C adrenergic receptor ADRA2C 0.0048
6103 Arylamine N-acetyltransferase 1 NAT1 0.0048
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
407 Vascular endothelial growth factor receptor 2 KDR 0.0047
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0046
380 Cytochrome P450 17A1 CYP17A1 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0046
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0046
291 Nitric-oxide synthase, endothelial NOS3 0.0046
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0045
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0045
474 Acetylcholinesterase ACHE 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0043
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0043
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0043
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0043
904 Glutathione S-transferase P GSTP1 0.0043
4773 Deoxycytidine kinase DCK 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
432 D(4) dopamine receptor DRD4 0.0042
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0042
161 Tubulin beta chain TUBB 0.0041
312 Tubulin beta chain TUB2 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
106 Cannabinoid receptor 2 CNR2 0.0041
408 Riboflavin kinase RFK 0.0041
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0041
5818 Folate receptor alpha FOLR1 0.0041
856 Vitamin D3 receptor VDR 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
908 Glutathione S-transferase theta-1 GSTT1 0.0041
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.004
1039 Histone deacetylase 9 HDAC9 0.004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.004
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.004
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.004
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.004
6146 High affinity copper uptake protein 1 SLC31A1 0.004
814 Ryanodine receptor 1 RYR1 0.0039
1541 Metalloproteinase mmp20 0.0039
5482 Sialidase-2 NEU2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0039
1196 Complement decay-accelerating factor CD55 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0038
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0038
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
2183 Fatty acid-binding protein, adipocyte FABP4 0.0037
2472 Voltage-gated potassium channel kcsA 0.0037
6366 Voltage-gated potassium channel kcsA 0.0037
54 Prothrombin F2 0.0037
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0037
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0037
844 Epidermal growth factor receptor EGFR 0.0036
482 Glycine receptor subunit alpha-1 GLRA1 0.0036
528 5-hydroxytryptamine 1E receptor HTR1E 0.0036
228 Beta platelet-derived growth factor receptor PDGFRB 0.0036
997 Protein kinase C beta type PRKCB 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0035
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
758 Thyroid hormone receptor alpha THRA 0.0035
921 Glutamate receptor 2 GRIA2 0.0034
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
4120 NADPH--cytochrome P450 reductase POR 0.0033
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
2808 Chloramphenicol acetyltransferase 3 cat3 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0033
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
284 DNA-directed RNA polymerase beta chain rpoB 0.0032
5773 DNA-directed RNA polymerase beta chain rpoB 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0032
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
4203 Histamine N-methyltransferase HNMT 0.0031
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0031
94 5-hydroxytryptamine 4 receptor HTR4 0.0031
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0031
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
4192 DNA topoisomerase 2-beta TOP2B 0.0031
88 Retinoic acid receptor RXR-beta RXRB 0.003
705 Glutamate receptor 1 GRIA1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2417 Chloramphenicol acetyltransferase cat 0.003
3278 Chloramphenicol acetyltransferase cat 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2810 Dr hemagglutinin structural subunit draA 0.003
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.003
654 Flavin reductase BLVRB 0.0029
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0029
3830 Calreticulin CALR 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0029
3587 Gastrotropin FABP6 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
1010 Cytochrome P450 51A1 CYP51A1 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0028
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1618 High affinity nerve growth factor receptor NTRK1 0.0027
5126 Arginase rocF 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0027
6034 Hydroxyindole O-methyltransferase ASMT 0.0027
6035 Nuclear receptor ROR-beta RORB 0.0027
6036 Eosinophil peroxidase EPX 0.0027
163 D(1B) dopamine receptor DRD5 0.0027
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
1374 Natriuretic peptides B NPPB 0.0026
1827 Gap junction alpha-1 protein GJA1 0.0026
1908 Vascular cell adhesion protein 1 VCAM1 0.0026
26 Vascular endothelial growth factor receptor 3 FLT4 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0026
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
6138 Multidrug resistance protein 3 ABCB4 0.0025
32 Vascular endothelial growth factor receptor 1 FLT1 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
3814 Complement C1r subcomponent C1R 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
3809 Estrogen-related receptor gamma ESRRG 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
518 Peroxidase/catalase T katG 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6168 Solute carrier family 22 member 16 SLC22A16 0.0024
208 DNA-directed RNA polymerase beta' chain rpoC 0.0023
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0023
765 Indoleamine 2,3-dioxygenase IDO1 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0023
4122 Histone deacetylase 2 HDAC2 0.0023
581 Cytochrome P450 2R1 CYP2R1 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0022
2782 Complement C1s subcomponent C1S 0.0022
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0022
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0022
16 Adenosine A1 receptor ADORA1 0.0022
2207 Rhodopsin RHO 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
2232 Interleukin-5 IL5 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0021
1256 5-hydroxytryptamine 6 receptor HTR6 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1178 Adenosine A2a receptor ADORA2A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
896 Glutathione S-transferase Mu 1 GSTM1 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
751 Potassium channel subfamily K member 6 KCNK6 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
1864 RET proto-oncogene RET 0.0019
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0019
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0019
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0019
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0019
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
537 ATP synthase delta chain, mitochondrial ATP5D 0.0018
172 Potassium channel subfamily K member 1 KCNK1 0.0018
164 Histamine H4 receptor HRH4 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
683 Potassium transporter GK0582 0.0018
239 Coagulation factor X F10 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
199 Monocarboxylate transporter 8 SLC16A2 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6174 50S ribosomal protein L32 rpmF 0.0017
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
2300 Lysozyme E 0.0016
3633 Lysozyme R 0.0016
5597 Lysozyme 17 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0016
563 Thyroid peroxidase TPO 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3233 Bile acid receptor NR1H4 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0015
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0015
5787 Angiopoietin-1 receptor TEK 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0015
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0015
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0015
1341 Histamine H3 receptor HRH3 0.0014
2693 Heat-labile enterotoxin B chain eltB 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0014
4948 Cytochrome c-553 Not Available 0.0014
4923 Cytochrome c3 DvMF_2499 0.0014
4945 Cytochrome c3 Not Available 0.0014
4949 Cytochrome c3 DVU_3171 0.0014
4968 Cytochrome c3 cytc3 0.0014
4997 Cytochrome c3 SO_2727 0.0014
5219 Cytochrome c3 cyd 0.0014
3189 High-molecular-weight cytochrome c hmcA 0.0014
4902 Nine-heme cytochrome c Ddes_2038 0.0014
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0014
6645 D-amino-acid oxidase DAO 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0014
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0014
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0013
165 FL cytokine receptor FLT3 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0012
4386 Hemoglobin-like protein HbN glbN 0.0012
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0012
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
1295 Fatty acid synthase FASN 0.0012
702 UMP-CMP kinase CMPK1 0.0012
1992 Vitamin D-binding protein GC 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
319 Opioid receptor, sigma 1 OPRS1 0.0012
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4943 Cytochrome c6 petJ 0.0011
4954 Soluble cytochrome b558 Not Available 0.0011
4934 Cytochrome c-551 nirM 0.0011
5218 Cytochrome c-551 nirM 0.0011
4905 Cytochrome c2 Not Available 0.0011
4939 Cytochrome c2 cycA 0.0011
4964 Cytochrome c2 cycA 0.0011
4979 Cytochrome c2 cycA 0.0011
6673 Cytochrome c2 cycA 0.0011
4984 Neuroglobin NGB 0.0011
4925 Cytochrome c-type protein SHP shp 0.0011
4994 Hemoglobin-like protein HbO glbO 0.0011
4947 Bacterial hemoglobin vhb 0.0011
4916 Cyanoglobin glbN 0.0011
4915 Cytochrome c-550 psbV 0.0011
4959 Cytochrome c-550 psbV 0.0011
5216 Cytochrome c-550 psbV 0.0011
4998 Hemoglobin-like protein yjbI yjbI 0.0011
4942 Diheme cytochrome c napB napB 0.0011
4975 Cytochrome c-556 RPA3973 0.0011
4936 Cytochrome c2 iso-2 Not Available 0.0011
4961 Hemophore HasA hasA 0.0011
4910 Cytoglobin CYGB 0.0011
4981 Iron-starvation protein PigA pigA 0.0011
5000 HemO hemO 0.0011
4904 Cytochrome c family protein GSU1996 0.0011
644 Heme oxygenase 2 HMOX2 0.0011
4982 Heme oxygenase 2 pbsA2 0.0011
3116 Bacterioferritin bfr 0.0011
4906 Bacterioferritin bfr 0.0011
4965 Bacterioferritin bfr 0.0011
4909 CooA protein cooA 0.0011
4907 Cytochrome c-L moxG 0.0011
6865 Cytochrome c-L moxG 0.0011
4976 Apocytochrome f petA 0.0011
6407 Apocytochrome f petA 0.0011
4971 Nonaheme cytochrome c hmcA 0.0011
4764 Cytochrome P450 165C4 CYP165C4 0.0011
4989 Cytochrome c551 peroxidase ccp 0.0011
5222 Cytochrome c551 peroxidase ccpA 0.0011
4935 Cytochrome c-554 cycA1 0.0011
4937 Cytochrome oxidase subunit II rcoxA 0.0011
4926 Heme-based aerotactic transducer hemAT hemAT 0.0011
4960 Putative cytochrome P450-family protein SCO7417 0.0011
4931 Cytochrome P450 167A1 CYP167A1 0.0011
4999 Cytochrome P450 165B3 CYP165B3 0.0011
4972 P450cin cinA 0.0011
4993 Hydroxylamine oxidoreductase hao1 0.0011
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0011
4952 Catalase/peroxidase katA 0.0011
4922 Cytochrome c, putative SO_4144 0.0011
4903 Methyl-accepting chemotaxis protein Tar4 0.0011
3093 Catalase HPII katE 0.0011
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3221 Cytochrome c4 cc4 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
976 Platelet glycoprotein IX GP9 0.0011
1630 Integrin beta-2 ITGB2 0.0011
2298 Cytochrome P450-cam camC 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
3937 Fatty-acid amide hydrolase FAAH 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0011
469 Annexin A1 ANXA1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
5251 Carbonyl reductase [NADPH] 1 CBR1 0.001
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.001
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.001
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
251 Alcohol dehydrogenase 1A ADH1A 0.001
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.001
174 Sigma 1-type opioid receptor SIGMAR1 0.001
936 Ephrin type-A receptor 2 EPHA2 0.001
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.001
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.001
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.001
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.001
6493 Cytochrome c oxidase subunit 6C COX6C 0.001
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.001
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.001
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.001
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.001
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.001
6559 Cytochrome c oxidase subunit 2 ctaC 0.001
6669 Cytochrome c oxidase subunit 2 ctaC 0.001
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.001
371 Cytochrome c oxidase subunit 1 MT-CO1 0.001
6558 Cytochrome c oxidase subunit 1 ctaD 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
719 Retinoic acid receptor responder protein 1 RARRES1 0.0009
770 Retinoic acid-induced protein 3 GPRC5A 0.0009
820 Glycine receptor subunit alpha-2 GLRA2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6044 Serum paraoxonase/lactonase 3 PON3 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
2540 Choloylglycine hydrolase cbh 0.0009
444 Alcohol dehydrogenase 1B ADH1B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
1184 Interferon beta IFNB1 0.0008
4920 Peroxidase/catalase katG 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
572 Integrin alpha-L ITGAL 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2119 Cytochrome b5 CYB5A 0.0008
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0008
4037 Hypothetical protein GPX1 0.0008
4297 Hypothetical protein SP_1951 0.0008
4521 Hypothetical protein BC_2969 0.0008
4540 Hypothetical protein TM_1070 0.0008
4555 Hypothetical protein MT1739 0.0008
4569 Hypothetical protein mshD 0.0008
4578 Hypothetical protein PA3270 0.0008
4747 Hypothetical protein PA3967 0.0008
5177 Hypothetical protein TM_0096 0.0008
5194 Hypothetical protein PA1204 0.0008
5240 Hypothetical protein Rv2991 0.0008
5370 Hypothetical protein TM_1158 0.0008
5710 Hypothetical protein Tb927.5.1360 0.0008
4990 PpcA ppcA 0.0008
4289 Cytochrome P450 TT_P0059 0.0008
6262 Cytochrome P450 staP 0.0008
3570 Cytochrome P450 152A1 cypC 0.0008
4992 Cytochrome c peroxidase Not Available 0.0008
4988 Sulfite oxidase, mitochondrial SUOX 0.0008
2915 Sensor protein fixL fixL 0.0008
4944 Sensor protein fixL fixL 0.0008
3375 Acidic cytochrome c3 Not Available 0.0008
4385 Cytochrome c' Not Available 0.0008
4967 Cytochrome c' cycA 0.0008
5038 Cytochrome c' Not Available 0.0008
5223 Cytochrome c' cycP 0.0008
4813 Heme oxygenase hmuO 0.0008
5769 Heme oxygenase Not Available 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
267 Plasminogen activator inhibitor 1 SERPINE1 0.0008
2230 Catalase CAT 0.0008
3249 Catalase katA 0.0008
3625 Catalase katA 0.0008
4539 Catalase katA 0.0008
4941 Catalase katB 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6432 Transporter snf 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0008
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0008
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0008
2091 Endoplasmin HSP90B1 0.0008
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0008
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0008
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
3102 Flavohemoprotein hmp 0.0007
4969 Flavohemoprotein hmp 0.0007
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0007
4311 tRNA TRDMT1 0.0007
4325 tRNA trmD 0.0007
4328 tRNA trmD 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
2972 6-deoxyerythronolide B hydroxylase eryF 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
3957 Adenosine deaminase ADA 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
162 Retinoic acid receptor gamma-1 RARG 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
358 Cystathionine beta-synthase CBS 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
693 Hemoglobin subunit beta HBB 0.0005
2430 Chondroitinase B cslB 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0005
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
2252 Endoglucanase 5A cel5A 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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