DT-Web

DB01120 - Gliclazide


Identification
Name Gliclazide
Accession Number DB01120 (APRD00460)
Type small molecule
Description Gliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin secretion and meal-stimulated insulin release. Medications in this class differ in their dose, rate of absorption, duration of action, route of elimination and binding site on their target pancreatic β cell receptor. Sulfonylureas also increase peripheral glucose utilization, decrease hepatic gluconeogenesis and may increase the number and sensitivity of insulin receptors. Sulfonylureas are associated with weight gain, though less so than insulin. Due to their mechanism of action, sulfonylureas may cause hypoglycemia and require consistent food intake to decrease this risk. The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals. Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control). Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 323.411
Groups approved
Monoisotopic Weight 323.130362243
Pharmacology
Indication For the treatment of NIDDM in conjunction with diet and exercise.
Mechanism of action Gliclazide binds to the β cell sulfonyl urea receptor (SUR1). This binding subsequently blocks the ATP sensitive potassium channels. The binding results in closure of the channels and leads to a resulting decrease in potassium efflux leads to depolarization of the β cells. This opens voltage-dependent calcium channels in the β cell resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules.
Absorption Rapidly and well absorbed but may have wide inter- and intra-individual variability. Peak plasma concentrations occur within 4-6 hours of oral administration.
Protein binding 94%, highly bound to plasma proteins
Biotransformation Extensively metabolized in the liver. Less than 1% of the orally administered dose appears unchanged in the urine. Metabolites include oxidized and hydroxylated derivates, as well as glucuronic acid conjugates.
Route of elimination Metabolites and conjugates are eliminated primarily by the kidneys (60-70%) and also in the feces (10-20%).
Toxicity LD50=3000 mg/kg (orally in mice). Gliclazide and its metabolites may accumulate in those with severe hepatic and/or renal dysfunction. Symptoms of hypoglycemia include: dizziness, lack of energy, drowsiness, headache and sweating.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Acebutolol may decrease symptoms of hypoglycemia and increase the time required for the body to compensate for hypoglycemia.
Acetylsalicylic acid Acetylsalicylic acid increases the effect of the sulfonylurea, gliclazide.
Atenolol The beta-blocker, atenolol, may decrease symptoms of hypoglycemia.
Betaxolol The beta-blocker, betaxolol, may decrease symptoms of hypoglycemia.
Bevantolol The beta-blocker, bevantolol, may decrease symptoms of hypoglycemia.
Bismuth Subsalicylate The salicylate, bismuth subsalicylate, increases the effect of the sulfonylurea, gliclazide.
Bisoprolol The beta-blocker, bisoprolol, may decrease symptoms of hypoglycemia.
Carteolol The beta-blocker, carteolol, may decrease symptoms of hypoglycemia.
Carvedilol The beta-blocker, carvedilol, may decrease symptoms of hypoglycemia.
Chloramphenicol Chloramphenicol may increase the effect of sulfonylurea, gliclazide.
Clofibrate Clofibrate may increase the effect of sulfonylurea, gliclazide.
Dicumarol Dicumarol may increase the effect of sulfonylurea, gliclazide.
Esmolol The beta-blocker, esmolol, may decrease symptoms of hypoglycemia.
Glucosamine Possible hyperglycemia
Labetalol The beta-blocker, labetalol, may decrease symptoms of hypoglycemia.
Magnesium salicylate The salicylate, magnesium salicylate, increases the effect of the sulfonylurea, gliclazide.
Metoprolol The beta-blocker, metoprolol, may decrease symptoms of hypoglycemia.
Nadolol The beta-blocker, nadolol, may decrease symptoms of hypoglycemia.
Oxprenolol The beta-blocker, oxprenolol, may decrease symptoms of hypoglycemia.
Penbutolol The beta-blocker, penbutolol, may decrease symptoms of hypoglycemia.
Phenylbutazone Phenylbutazone increases the effect of the hypoglycemic agent
Pindolol The beta-blocker, pindolol, may decrease symptoms of hypoglycemia.
Practolol The beta-blocker, practolol, may decrease symptoms of hypoglycemia.
Propranolol The beta-blocker, propranolol, may decrease symptoms of hypoglycemia.
Rifampin Rifampin may decrease the effect of sulfonylurea, gliclazide.
Salicylate-sodium The salicylate, salicylate-sodium, increases the effect of the sulfonylurea, gliclazide.
Salsalate The salicylate, salsalate, increases the effect of the sulfonylurea, gliclazide.
Somatropin recombinant Somatropin may antagonize the hypoglycemic effect of gliclazide. Monitor for changes in fasting and postprandial blood sugars.
Sotalol The beta-blocker, sotalol, may decrease symptoms of hypoglycemia.
Timolol The beta-blocker, timolol, may decrease symptoms of hypoglycemia.
Trisalicylate-choline The salicylate, trisalicylate-choline, increases the effect of the sulfonylurea, gliclazide.
Food Interactions
  • Take without regard to meals. A consistent diet is recommended to reduce the risk of hypoglycemia.
  • Avoid alcohol.

Targets


ATP-binding cassette transporter sub-family C member 8
Name ATP-binding cassette transporter sub-family C member 8
Gene Name ABCC8
Pharmacological action yes
Actions binder
References
  • Gribble FM, Ashcroft FM: Sulfonylurea sensitivity of adenosine triphosphate-sensitive potassium channels from beta cells and extrapancreatic tissues. Metabolism. 2000 Oct;49(10 Suppl 2):3-6. - Pubmed
  • Harrower A: Gliclazide modified release: from once-daily administration to 24-hour blood glucose control. Metabolism. 2000 Oct;49(10 Suppl 2):7-11. - Pubmed
  • Lawrence CL, Proks P, Rodrigo GC, Jones P, Hayabuchi Y, Standen NB, Ashcroft FM: Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia. 2001 Aug;44(8):1019-25. - Pubmed
  • Reimann F, Ashcroft FM, Gribble FM: Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9. - Pubmed
  • Proks P, Reimann F, Green N, Gribble F, Ashcroft F: Sulfonylurea stimulation of insulin secretion. Diabetes. 2002 Dec;51 Suppl 3:S368-76. - Pubmed
DTHybrid score 0.3557
Vascular endothelial growth factor A
Name Vascular endothelial growth factor A
Gene Name VEGFA
Pharmacological action unknown
Actions other/unknown
References
  • Mamputu JC, Renier G: Advanced glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells. Inhibitory effect of gliclazide. J Diabetes Complications. 2002 Jul-Aug;16(4):284-93. - Pubmed
  • Mamputu JC, Renier G: Signalling pathways involved in retinal endothelial cell proliferation induced by advanced glycation end products: inhibitory effect of gliclazide. Diabetes Obes Metab. 2004 Mar;6(2):95-103. - Pubmed
  • Li L, Renier G: Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by advanced glycation end products links oxidative stress to altered retinal vascular endothelial growth factor expression. Metabolism. 2006 Nov;55(11):1516-23. - Pubmed
  • Kimura T, Takagi H, Suzuma K, Kita M, Watanabe D, Yoshimura N: Comparisons between the beneficial effects of different sulphonylurea treatments on ischemia-induced retinal neovascularization. Free Radic Biol Med. 2007 Aug 1;43(3):454-61. Epub 2007 May 3. - Pubmed
DTHybrid score 0.4713

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3678
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2954

Carriers


Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2104
4924 Cytochrome P450 2C8 CYP2C8 0.1393
5377 Placenta growth factor PGF 0.1355
4119 Cytochrome P450 2D6 CYP2D6 0.1243
4200 Cytochrome P450 1A2 CYP1A2 0.1132
1588 Multidrug resistance protein 1 ABCB1 0.1023
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0981
20 Prostaglandin G/H synthase 1 PTGS1 0.085
4118 Cytochrome P450 3A5 CYP3A5 0.076
6030 Cytochrome P450 2B6 CYP2B6 0.0735
1729 Solute carrier family 22 member 6 SLC22A6 0.0676
6013 Cytochrome P450 2E1 CYP2E1 0.0673
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0648
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0591
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0588
6107 Cytochrome P450 3A7 CYP3A7 0.0523
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0501
1334 Tissue factor pathway inhibitor TFPI 0.0471
290 Prostaglandin G/H synthase 2 PTGS2 0.0431
1719 Heparanase HPSE 0.0414
5718 Cytochrome P450 2A6 CYP2A6 0.0413
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0409
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0405
6024 Cytochrome P450 1A1 CYP1A1 0.0396
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0382
6106 Cytochrome P450 2C18 CYP2C18 0.0377
2058 P-selectin SELP 0.0373
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0371
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0363
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0357
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0353
862 Multidrug resistance-associated protein 1 ABCC1 0.0334
891 Dihydropteroate synthase folP 0.0327
5359 Dihydropteroate synthase folP 0.0327
7175 Dihydropteroate synthase sulI 0.0327
6142 Solute carrier family 22 member 8 SLC22A8 0.0317
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.031
309 Antithrombin-III SERPINC1 0.0304
6143 Solute carrier family 22 member 7 SLC22A7 0.0286
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0279
1024 Solute carrier family 22 member 11 SLC22A11 0.0266
220 Sodium channel protein type 5 subunit alpha SCN5A 0.024
2164 Multidrug resistance-associated protein 4 ABCC4 0.023
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0226
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0226
844 Epidermal growth factor receptor EGFR 0.0223
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0221
5787 Angiopoietin-1 receptor TEK 0.0209
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0207
824 Sodium-dependent serotonin transporter SLC6A4 0.0204
492 Histamine H1 receptor HRH1 0.0203
6145 Solute carrier family 22 member 1 SLC22A1 0.02
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0198
4411 DNA protection during starvation protein dps 0.0197
5423 UPF0010 protein HI1317 HI_1317 0.0197
3780 Lipoprotein nlpI precursor nlpI 0.0197
5424 Endonuclease VIII-like 1 NEIL1 0.0197
502 5-hydroxytryptamine 2A receptor HTR2A 0.0179
556 Alpha-1A adrenergic receptor ADRA1A 0.0176
3164 Biotin synthase bioB 0.0173
3186 Soluble calcium-activated nucleotidase 1 CANT1 0.0172
5036 Small inducible cytokine A8 CCL8 0.017
5012 Ig lambda chain V-II region MGC Not Available 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
3221 Cytochrome c4 cc4 0.0163
776 Bile salt export pump ABCB11 0.0159
3583 6-phosphogluconolactonase pgl 0.0159
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0154
3259 Autolysin lytA 0.0151
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0149
5023 Glycoside hydrolase Not Available 0.0148
5024 Glycoside hydrolase Not Available 0.0148
4771 Dissimilatory copper-containing nitrite reductase nir 0.0148
5006 RNASE4 protein RNASE4 0.0148
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0147
766 Beta-2 adrenergic receptor ADRB2 0.0146
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0145
1654 Interleukin-1 beta IL1B 0.0145
65 Matrix metalloproteinase-9 Not Available 0.0145
3811 Cytochrome P450 19A1 CYP19A1 0.0144
831 D(2) dopamine receptor DRD2 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
540 Sodium-dependent noradrenaline transporter SLC6A2 0.014
122 P2Y purinoceptor 12 P2RY12 0.0139
1898 Cytochrome P450 1B1 CYP1B1 0.0139
3817 Complement C1q subcomponent subunit C C1QC 0.0138
3816 Complement C1q subcomponent subunit B C1QB 0.0138
3815 Complement C1q subcomponent subunit A C1QA 0.0138
494 Caspase-1 CASP1 0.0136
6144 Solute carrier family 22 member 2 SLC22A2 0.0136
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0136
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0136
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0136
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0136
3814 Complement C1r subcomponent C1R 0.0136
2149 Angiogenin ANG 0.0136
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0135
275 Arachidonate 5-lipoxygenase ALOX5 0.0133
1507 Cytochrome c CYCS 0.0132
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.013
136 Estrogen receptor ESR1 0.013
731 HIV-1 protease HIV-1 protease 0.013
260 Cytochrome P450 51 ERG11 0.0129
761 Cytochrome P450 51 ERG11 0.0129
3163 Cytochrome P450 51 cyp51 0.0129
1374 Natriuretic peptides B NPPB 0.0129
1827 Gap junction alpha-1 protein GJA1 0.0128
23 D(1A) dopamine receptor DRD1 0.0128
1908 Vascular cell adhesion protein 1 VCAM1 0.0128
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0126
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0125
70 Type-1 angiotensin II receptor AGTR1 0.0124
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0123
3030 Salivary alpha-amylase AMY1A 0.0123
2723 Cholera enterotoxin subunit B ctxB 0.0118
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0117
22 30S ribosomal protein S4 rpsD 0.0117
6714 30S ribosomal protein S4 rpsD 0.0117
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0117
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0116
2077 Caspase-3 CASP3 0.0116
6374 Disintegrin and metalloproteinase domain-containing protein 28 ADAM28 0.0116
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0115
632 Alpha-1B adrenergic receptor ADRA1B 0.0115
738 Monocarboxylate transporter 1 SLC16A1 0.0113
2430 Chondroitinase B cslB 0.0111
320 5-hydroxytryptamine 1A receptor HTR1A 0.0111
193 Beta-1 adrenergic receptor ADRB1 0.0111
140 30S ribosomal protein S9 rpsI 0.011
6719 30S ribosomal protein S9 rpsI 0.011
6725 30S ribosomal protein S9 rpsI 0.011
146 Androgen receptor AR 0.0109
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0109
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0108
3941 Amine oxidase [flavin-containing] A MAOA 0.0107
713 Sodium-dependent dopamine transporter SLC6A3 0.0107
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0106
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0106
118 Organic cation/carnitine transporter 2 SLC22A5 0.0104
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0101
4513 Pancreatic alpha-amylase AMY2A 0.0098
2211 Fatty acid-binding protein, heart FABP3 0.0098
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0097
566 Serotransferrin TF 0.0094
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0094
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0092
756 Sex hormone-binding globulin SHBG 0.0092
341 5-hydroxytryptamine 3 receptor HTR3A 0.0092
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0091
482 Glycine receptor subunit alpha-1 GLRA1 0.0091
590 5-hydroxytryptamine 2C receptor HTR2C 0.0089
3939 Amine oxidase [flavin-containing] B MAOB 0.0088
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0087
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0087
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0087
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0087
468 Cytochrome P450 4A11 CYP4A11 0.0086
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0084
6085 Fatty acid-binding protein, intestinal FABP2 0.0083
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0077
6031 Cytochrome P450 3A43 CYP3A43 0.0077
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0077
4604 Liver carboxylesterase 1 CES1 0.0077
6141 Sodium/bile acid cotransporter SLC10A1 0.0076
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0076
696 Kappa-type opioid receptor OPRK1 0.0076
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0075
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0075
558 Solute carrier family 12 member 1 SLC12A1 0.0073
847 Mu-type opioid receptor OPRM1 0.0073
537 ATP synthase delta chain, mitochondrial ATP5D 0.0072
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
373 Transthyretin TTR 0.0072
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
645 Penicillin-binding protein 1A mrcA 0.0071
5805 Penicillin-binding protein 1A ponA 0.0071
6185 Penicillin-binding protein 1A mrcA 0.0071
6799 Penicillin-binding protein 1A pbpA 0.0071
3947 Xanthine dehydrogenase/oxidase XDH 0.0071
49 Endothelin B receptor EDNRB 0.007
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0069
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0069
6136 Multidrug resistance-associated protein 5 ABCC5 0.0069
811 Translocator protein TSPO 0.0068
2853 14 kDa fatty acid-binding protein Not Available 0.0068
318 Alpha-2A adrenergic receptor ADRA2A 0.0068
705 Glutamate receptor 1 GRIA1 0.0067
6102 Arylamine N-acetyltransferase 2 NAT2 0.0067
465 Calmodulin CALM1 0.0066
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0066
36 Insulin receptor INSR 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
6147 Solute carrier family 22 member 3 SLC22A3 0.0065
467 Delta-type opioid receptor OPRD1 0.0064
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
133 Dihydropterate synthase sulI 0.0063
789 Alpha-1D adrenergic receptor ADRA1D 0.0063
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0062
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0062
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0062
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0062
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0059
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0059
362 Melatonin receptor type 1B MTNR1B 0.0058
571 Melatonin receptor type 1A MTNR1A 0.0058
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0058
592 Carbonic anhydrase 4 CA4 0.0058
2183 Fatty acid-binding protein, adipocyte FABP4 0.0058
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0057
6137 Multidrug resistance-associated protein 6 ABCC6 0.0056
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0055
6182 Cytochrome P450 2J2 CYP2J2 0.0054
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0054
817 DNA topoisomerase 2-alpha TOP2A 0.0054
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0054
459 Retinoic acid receptor RXR-alpha RXRA 0.0053
357 Carbonic anhydrase 2 CA2 0.0053
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0053
124 Histamine H2 receptor HRH2 0.0052
380 Cytochrome P450 17A1 CYP17A1 0.0052
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.005
3810 Catechol O-methyltransferase COMT 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0049
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0049
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0049
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0049
340 Apoptotic protease-activating factor 1 APAF1 0.0049
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0048
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0048
1656 CYP2B protein CYP2B 0.0047
1757 Myeloperoxidase MPO 0.0047
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0047
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0047
295 Carbonic anhydrase 1 CA1 0.0047
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
365 Dihydrofolate reductase DHFR 0.0046
2381 Dihydrofolate reductase DFR1 0.0046
2833 Dihydrofolate reductase Not Available 0.0046
2931 Dihydrofolate reductase folA 0.0046
3544 Dihydrofolate reductase folA 0.0046
3682 Dihydrofolate reductase folA 0.0046
6642 Dihydrofolate reductase folA 0.0046
6756 Dihydrofolate reductase dfrA 0.0046
3923 Cholinesterase BCHE 0.0046
527 Prostacyclin receptor PTGIR 0.0045
777 Tumor necrosis factor TNF 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0044
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
825 Arsenical pump-driving ATPase ASNA1 0.0043
3435 Arsenical pump-driving ATPase arsA 0.0043
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0043
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0043
733 Activin receptor type 1B ACVR1B 0.0043
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0043
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0043
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0043
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0043
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0043
154 AFG3-like protein 2 AFG3L2 0.0043
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0043
395 ALK tyrosine kinase receptor Not Available 0.0043
614 Progesterone receptor PGR 0.0043
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0043
869 Estrogen receptor beta ESR2 0.0043
427 Substance-P receptor TACR1 0.0043
885 5-hydroxytryptamine 1B receptor HTR1B 0.0042
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0041
6014 Cytochrome P450 2A13 CYP2A13 0.0041
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0041
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0041
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.004
404 DNA gyrase subunit A gyrA 0.004
6224 DNA gyrase subunit A gyrA 0.004
477 DNA topoisomerase 4 subunit A parC 0.004
886 DNA topoisomerase 4 subunit A parC 0.004
6226 DNA topoisomerase 4 subunit A parC 0.004
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
633 Penicillin-binding proteins 1A/1B pbpA 0.004
6126 Carbonic anhydrase 7 CA7 0.004
833 Organic cation/carnitine transporter 1 SLC22A4 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.0039
6220 Aryl hydrocarbon receptor AHR 0.0039
6148 Multidrug resistance-associated protein 7 ABCC10 0.0039
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
407 Vascular endothelial growth factor receptor 2 KDR 0.0038
1618 High affinity nerve growth factor receptor NTRK1 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
780 Retinoic acid receptor RXR-gamma RXRG 0.0038
292 Activin receptor type-1 ACVR1 0.0038
849 Activated CDC42 kinase 1 TNK2 0.0038
921 Glutamate receptor 2 GRIA2 0.0038
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0038
297 Adenylate cyclase type 1 ADCY1 0.0038
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0038
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0038
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0038
504 Mast/stem cell growth factor receptor KIT 0.0037
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0037
629 Alpha-2B adrenergic receptor ADRA2B 0.0037
130 Prostacyclin synthase PTGIS 0.0037
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0037
638 D(3) dopamine receptor DRD3 0.0037
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0036
6149 Solute carrier family 22 member 10 SLC22A10 0.0036
1992 Vitamin D-binding protein GC 0.0036
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0036
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0036
1275 Estrogen sulfotransferase SULT1E1 0.0036
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0035
484 Tyrosine-protein kinase ABL2 ABL2 0.0035
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0035
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0035
6103 Arylamine N-acetyltransferase 1 NAT1 0.0035
88 Retinoic acid receptor RXR-beta RXRB 0.0035
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
2981 Phospholipase A2, membrane associated PLA2G2A 0.0034
4120 NADPH--cytochrome P450 reductase POR 0.0034
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0034
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0033
740 Argininosuccinate synthase ASS1 0.0032
865 Argininosuccinate synthase ASS1 0.0032
2680 Argininosuccinate synthase argG 0.0032
3194 Argininosuccinate synthase argG 0.0032
594 Thyroxine-binding globulin SERPINA7 0.0032
725 5-hydroxytryptamine 1D receptor HTR1D 0.0032
1010 Cytochrome P450 51A1 CYP51A1 0.0032
6677 Myelin P2 protein PMP2 0.0032
528 5-hydroxytryptamine 1E receptor HTR1E 0.0032
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0032
595 Fibrinogen alpha chain FGA 0.0032
228 Beta platelet-derived growth factor receptor PDGFRB 0.0031
3426 Glutamine synthetase glnA 0.0031
3987 Glutamine synthetase GLUL 0.0031
94 5-hydroxytryptamine 4 receptor HTR4 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0031
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0031
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0031
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0031
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.003
6021 Adenosine kinase ADK 0.003
26 Vascular endothelial growth factor receptor 3 FLT4 0.003
758 Thyroid hormone receptor alpha THRA 0.003
432 D(4) dopamine receptor DRD4 0.003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.003
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
661 ADP/ATP translocase 1 SLC25A4 0.0029
871 Glucocorticoid receptor NR3C1 0.0029
3932 Glutathione S-transferase A2 GSTA2 0.0029
6033 High affinity interleukin-8 receptor A CXCR1 0.0029
6432 Transporter snf 0.0029
32 Vascular endothelial growth factor receptor 1 FLT1 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
5934 Cytochrome P450 26A1 CYP26A1 0.0028
823 Fibroblast growth factor receptor 2 FGFR2 0.0028
161 Tubulin beta chain TUBB 0.0028
312 Tubulin beta chain TUB2 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
716 5-hydroxytryptamine 7 receptor HTR7 0.0027
3639 Thymidine phosphorylase deoA 0.0027
3936 Thymidine phosphorylase TYMP 0.0027
346 Thyroid hormone receptor beta-1 THRB 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
4217 Telomerase reverse transcriptase TERT 0.0027
518 Peroxidase/catalase T katG 0.0026
54 Prothrombin F2 0.0026
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0026
153 Dopamine beta-hydroxylase DBH 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0026
1517 Beta-3 adrenergic receptor ADRB3 0.0025
85 Growth hormone receptor GHR 0.0025
1050 Bile salt sulfotransferase SULT2A1 0.0025
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
1541 Metalloproteinase mmp20 0.0025
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0025
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0025
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0024
1867 Major prion protein PRNP 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0024
378 Alpha-2C adrenergic receptor ADRA2C 0.0024
6231 Pepsin A PGA3 0.0024
6174 50S ribosomal protein L32 rpmF 0.0024
4238 50S ribosomal protein L4 rplD 0.0024
5578 50S ribosomal protein L4 rplD 0.0024
6173 50S ribosomal protein L4 rplD 0.0024
6219 50S ribosomal protein L4 rplD 0.0024
1196 Complement decay-accelerating factor CD55 0.0023
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0023
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0023
68 Cannabinoid receptor 1 CNR1 0.0022
563 Thyroid peroxidase TPO 0.0022
33 Cystine/glutamate transporter SLC7A11 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
2021 Thrombomodulin THBD 0.0022
2539 Tubulin alpha-1 chain TUBA4A 0.0022
707 72 kDa type IV collagenase MMP2 0.0021
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0021
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
634 Squalene monooxygenase SQLE 0.0021
7196 Squalene monooxygenase ERG1 0.0021
6209 30S ribosomal protein S19 rpsS 0.0021
6712 30S ribosomal protein S19 rpsS 0.0021
6726 30S ribosomal protein S19 rpsS 0.0021
6207 30S ribosomal protein S14 rpsN 0.0021
2320 Thymidine kinase, cytosolic TK1 0.0021
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0021
5300 Antigen peptide transporter 1 TAP1 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
1864 RET proto-oncogene RET 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.002
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.002
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
2808 Chloramphenicol acetyltransferase 3 cat3 0.002
768 FK506-binding protein 1A FKBP1A 0.002
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.002
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.002
273 Apoptosis regulator Bcl-2 BCL2 0.002
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.002
162 Retinoic acid receptor gamma-1 RARG 0.0019
2207 Rhodopsin RHO 0.0019
163 D(1B) dopamine receptor DRD5 0.0019
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0019
904 Glutathione S-transferase P GSTP1 0.0019
3808 Dihydropteroate synthase 2 folP2 0.0019
3601 Dihydropteroate synthase 1 folP1 0.0019
3807 Dihydropteroate synthase 1 folP1 0.0019
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0019
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0019
6218 Pannexin-1 PANX1 0.0019
4226 Uridine phosphorylase 2 UPP2 0.0018
2417 Chloramphenicol acetyltransferase cat 0.0018
3278 Chloramphenicol acetyltransferase cat 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
1253 Interferon gamma IFNG 0.0018
2810 Dr hemagglutinin structural subunit draA 0.0018
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0018
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0018
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0018
6146 High affinity copper uptake protein 1 SLC31A1 0.0018
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0018
581 Cytochrome P450 2R1 CYP2R1 0.0017
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1714 Mitogen-activated protein kinase 3 MAPK3 0.0017
4225 Uridine phosphorylase 1 UPP1 0.0017
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
3937 Fatty-acid amide hydrolase FAAH 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
3830 Calreticulin CALR 0.0017
3917 Methylenetetrahydrofolate reductase MTHFR 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
6042 Prostaglandin reductase 2 PTGR2 0.0016
319 Opioid receptor, sigma 1 OPRS1 0.0016
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0016
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0016
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
413 Amidophosphoribosyltransferase PPAT 0.0016
2515 Amidophosphoribosyltransferase purF 0.0016
3714 Amidophosphoribosyltransferase purF 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0016
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
244 Angiotensin-converting enzyme ACE 0.0016
4122 Histone deacetylase 2 HDAC2 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
1648 Elastin ELN 0.0015
976 Platelet glycoprotein IX GP9 0.0015
1630 Integrin beta-2 ITGB2 0.0015
1792 Tissue-type plasminogen activator PLAT 0.0015
4103 Proteasome subunit beta type 2 PSMB2 0.0015
4102 Proteasome subunit beta type 5 PSMB5 0.0015
4101 Proteasome subunit beta type 1 PSMB1 0.0015
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
3809 Estrogen-related receptor gamma ESRRG 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0015
164 Histamine H4 receptor HRH4 0.0015
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
511 5-hydroxytryptamine 1F receptor HTR1F 0.0014
239 Coagulation factor X F10 0.0014
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
251 Alcohol dehydrogenase 1A ADH1A 0.0014
1192 Sulfotransferase 1A1 SULT1A1 0.0014
174 Sigma 1-type opioid receptor SIGMAR1 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
4311 tRNA TRDMT1 0.0013
4325 tRNA trmD 0.0013
4328 tRNA trmD 0.0013
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0013
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0013
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0013
1268 Neuropeptide S receptor NPSR1 0.0013
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0013
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0013
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0013
6151 Monocarboxylate transporter 10 SLC16A10 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0013
818 50S ribosomal protein L10 rplJ 0.0013
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0013
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0013
820 Glycine receptor subunit alpha-2 GLRA2 0.0013
6459 Glycodelin PAEP 0.0013
1313 Lactoylglutathione lyase GLO1 0.0013
6044 Serum paraoxonase/lactonase 3 PON3 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
822 Aldose reductase AKR1B1 0.0012
7 Nitric oxide synthase, inducible NOS2 0.0012
444 Alcohol dehydrogenase 1B ADH1B 0.0012
856 Vitamin D3 receptor VDR 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0012
489 Monocarboxylate transporter 2 SLC16A7 0.0012
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0012
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0012
572 Integrin alpha-L ITGAL 0.0012
474 Acetylcholinesterase ACHE 0.0011
5798 Mitogen-activated protein kinase 11 MAPK11 0.0011
267 Plasminogen activator inhibitor 1 SERPINE1 0.0011
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0011
737 Mineralocorticoid receptor NR3C2 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0011
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0011
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0011
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0011
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0011
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0011
1629 Transcription factor AP-1 JUN 0.0011
517 Alcohol dehydrogenase 1C ADH1C 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
6221 Steroid hormone receptor ERR1 ESRRA 0.001
1039 Histone deacetylase 9 HDAC9 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
16 Adenosine A1 receptor ADORA1 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
1178 Adenosine A2a receptor ADORA2A 0.001
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
4948 Cytochrome c-553 Not Available 0.0009
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0009
4923 Cytochrome c3 DvMF_2499 0.0009
4945 Cytochrome c3 Not Available 0.0009
4949 Cytochrome c3 DVU_3171 0.0009
4968 Cytochrome c3 cytc3 0.0009
4997 Cytochrome c3 SO_2727 0.0009
5219 Cytochrome c3 cyd 0.0009
4902 Nine-heme cytochrome c Ddes_2038 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1341 Histamine H3 receptor HRH3 0.0009
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0009
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0009
936 Ephrin type-A receptor 2 EPHA2 0.0009
165 FL cytokine receptor FLT3 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0009
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0009
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0008
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0008
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0008
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0008
469 Annexin A1 ANXA1 0.0008
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
735 Alanine aminotransferase 1 GPT 0.0008
3904 Alanine aminotransferase 2 GPT2 0.0008
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0008
284 DNA-directed RNA polymerase beta chain rpoB 0.0008
5773 DNA-directed RNA polymerase beta chain rpoB 0.0008
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0008
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0008
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0008
4773 Deoxycytidine kinase DCK 0.0008
5818 Folate receptor alpha FOLR1 0.0007
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0007
6020 Aldehyde oxidase AOX1 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
293 Gamma-glutamyl hydrolase GGH 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
952 Dipeptidyl peptidase 4 DPP4 0.0006
828 Phenylalanine-4-hydroxylase PAH 0.0006
3109 Phenylalanine-4-hydroxylase phhA 0.0006
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0006
1650 Heme carrier protein 1 SLC46A1 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0005
5961 Insulin INS 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0005
4916 Cyanoglobin glbN 0.0005
5000 HemO hemO 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4984 Neuroglobin NGB 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4910 Cytoglobin CYGB 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4909 CooA protein cooA 0.0005
4961 Hemophore HasA hasA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4972 P450cin cinA 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0004
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0004
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
6131 Carbonic anhydrase 14 CA14 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
3957 Adenosine deaminase ADA 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6122 Carbonic anhydrase 3 CA3 0.0004
908 Glutathione S-transferase theta-1 GSTT1 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0004
4920 Peroxidase/catalase katG 0.0003
2119 Cytochrome b5 CYB5A 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
4990 PpcA ppcA 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
3007 Carbonic anhydrase 12 CA12 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4205 Carbonic anhydrase 9 CA9 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
605 Fumarate reductase flavoprotein subunit frdA 0.0003
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0003
3673 Fumarate reductase flavoprotein subunit fccA 0.0003
4912 Fumarate reductase flavoprotein subunit ifcA 0.0003
6549 Fumarate reductase flavoprotein subunit frdA 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
358 Cystathionine beta-synthase CBS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
2298 Cytochrome P450-cam camC 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
↑