DT-Web

DB01296 - Glucosamine


Identification
Name Glucosamine
Accession Number DB01296 (EXPT01563)
Type small molecule
Description Glucosamine is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies. It is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 179.1711
Groups approved
Monoisotopic Weight 179.079372531
Pharmacology
Indication Not Available
Mechanism of action Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Oral glucosamine is commonly used for the treatment of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis. Its use as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness with more recent studies showing limited to no clinical benefit of use. In the United States, glucosamine is not approved by the Food and Drug Administration for medical use in humans. Since glucosamine is classified as a dietary supplement, safety and formulation are solely the responsibility of the manufacturer; evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Chlorpropamide Possible hyperglycemia
Gliclazide Possible hyperglycemia
Glimepiride Possible hyperglycemia
Glyburide Possible hyperglycemia
Metformin Possible hyperglycemia
Miglitol Possible hyperglycemia
Nateglinide Possible hyperglycemia
Pioglitazone Possibly hyperglycemia
Repaglinide Possible hyperglycemia
Food Interactions Not Available

Targets


Matrix metalloproteinase-9
Name Matrix metalloproteinase-9
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Fenton JI, Chlebek-Brown KA, Caron JP, Orth MW: Effect of glucosamine on interleukin-1-conditioned articular cartilage. Equine Vet J Suppl. 2002 Sep;(34):219-23. - Pubmed
  • Mendis E, Kim MM, Rajapakse N, Kim SK: Carboxy derivatized glucosamine is a potent inhibitor of matrix metalloproteinase-9 in HT1080 cells. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3105-10. Epub 2006 Apr 17. - Pubmed
  • Chu SC, Yang SF, Lue KH, Hsieh YS, Lee CY, Chou MC, Lu KH: Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis. Clin Chim Acta. 2006 Oct;372(1-2):167-72. Epub 2006 Jun 6. - Pubmed
  • Rajapakse N, Mendis E, Kim MM, Kim SK: Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cells. Bioorg Med Chem. 2007 Jul 15;15(14):4891-6. Epub 2007 Apr 29. - Pubmed
  • Dodge GR, Jimenez SA: Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarthritis Cartilage. 2003 Jun;11(6):424-32. - Pubmed
DTHybrid score 1.2291
Nuclear factor NF-kappa-B p100 subunit
Name Nuclear factor NF-kappa-B p100 subunit
Gene Name NFKB2
Pharmacological action unknown
Actions antagonist
References
  • Largo R, Alvarez-Soria MA, Diez-Ortego I, Calvo E, Sanchez-Pernaute O, Egido J, Herrero-Beaumont G: Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2003 Apr;11(4):290-8. - Pubmed
DTHybrid score 0.6983
Tumor necrosis factor
Name Tumor necrosis factor
Gene Name TNF
Pharmacological action unknown
Actions Not Available
References
  • Delcommenne M, Kannagi R, Johnson P: TNF-alpha increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans. Glycobiology. 2002 Oct;12(10):613-22. - Pubmed
  • Bitler CM, Viale TM, Damaj B, Crea R: Hydrolyzed olive vegetation water in mice has anti-inflammatory activity. J Nutr. 2005 Jun;135(6):1475-9. - Pubmed
  • Chen JT, Liang JB, Chou CL, Chien MW, Shyu RC, Chou PI, Lu DW: Glucosamine sulfate inhibits TNF-alpha and IFN-gamma-induced production of ICAM-1 in human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci. 2006 Feb;47(2):664-72. - Pubmed
  • Yi HA, Yi SD, Jang BC, Song DK, Shin DH, Mun KC, Kim SP, Suh SI, Bae JH: Inhibitory effects of glucosamine on lipopolysaccharide-induced activation in microglial cells. Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1097-103. - Pubmed
  • Lapaque N, Takeuchi O, Corrales F, Akira S, Moriyon I, Howard JC, Gorvel JP: Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides. Cell Microbiol. 2006 Mar;8(3):401-13. - Pubmed
DTHybrid score 0.9807
Interferon gamma
Name Interferon gamma
Gene Name IFNG
Pharmacological action unknown
Actions Not Available
References
  • Sarrazin S, Bonnaffe D, Lubineau A, Lortat-Jacob H: Heparan sulfate mimicry: a synthetic glycoconjugate that recognizes the heparin binding domain of interferon-gamma inhibits the cytokine activity. J Biol Chem. 2005 Nov 11;280(45):37558-64. Epub 2005 Sep 9. - Pubmed
  • Chen JT, Liang JB, Chou CL, Chien MW, Shyu RC, Chou PI, Lu DW: Glucosamine sulfate inhibits TNF-alpha and IFN-gamma-induced production of ICAM-1 in human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci. 2006 Feb;47(2):664-72. - Pubmed
  • Lortat-Jacob H: Interferon and heparan sulphate. Biochem Soc Trans. 2006 Jun;34(Pt 3):461-4. - Pubmed
  • Chen JT, Chen CH, Horng CT, Chien MW, Lu DW, Liang JB, Tai MC, Chang YH, Chen PL, Chen YH: Glucosamine sulfate inhibits proinflammatory cytokine-induced icam-1 production in human conjunctival cells in vitro. J Ocul Pharmacol Ther. 2006 Dec;22(6):402-16. - Pubmed
DTHybrid score 0.9177
Chitosanase
Name Chitosanase
Gene Name csn
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Kurakake M, Yo-u S, Nakagawa K, Sugihara M, Komaki T: Properties of chitosanase from Bacillus cereus S1. Curr Microbiol. 2000 Jan;40(1):6-9. - Pubmed
  • Kimoto H, Kusaoke H, Yamamoto I, Fujii Y, Onodera T, Taketo A: Biochemical and genetic properties of Paenibacillus glycosyl hydrolase having chitosanase activity and discoidin domain. J Biol Chem. 2002 Apr 26;277(17):14695-702. Epub 2002 Feb 19. - Pubmed
  • Shimono K, Shigeru K, Tsuchiya A, Itou N, Ohta Y, Tanaka K, Nakagawa T, Matsuda H, Kawamukai M: Two glutamic acids in chitosanase A from Matsuebacter chitosanotabidus 3001 are the catalytically important residues. J Biochem (Tokyo). 2002 Jan;131(1):87-96. - Pubmed
DTHybrid score 0.6984

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3599
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3656

Predictions


Id Partner name Gene Name Score
1405 Thiopurine S-methyltransferase TPMT 0.2191
4512 Cytochrome P450 3A4 CYP3A4 0.1568
4757 Cytochrome P450 2C9 CYP2C9 0.1376
4200 Cytochrome P450 1A2 CYP1A2 0.1193
4119 Cytochrome P450 2D6 CYP2D6 0.1072
1588 Multidrug resistance protein 1 ABCB1 0.0805
4924 Cytochrome P450 2C8 CYP2C8 0.0785
6024 Cytochrome P450 1A1 CYP1A1 0.0658
4118 Cytochrome P450 3A5 CYP3A5 0.0626
6030 Cytochrome P450 2B6 CYP2B6 0.0598
5718 Cytochrome P450 2A6 CYP2A6 0.0451
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0426
290 Prostaglandin G/H synthase 2 PTGS2 0.0414
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0368
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0366
6107 Cytochrome P450 3A7 CYP3A7 0.0355
587 Serum albumin ALB 0.0333
20 Prostaglandin G/H synthase 1 PTGS1 0.0327
1729 Solute carrier family 22 member 6 SLC22A6 0.028
1820 Beta-nerve growth factor NGF 0.0274
707 72 kDa type IV collagenase MMP2 0.027
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0217
2782 Complement C1s subcomponent C1S 0.0213
2232 Interleukin-5 IL5 0.0211
1593 Mucin-2 MUC2 0.021
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0209
6106 Cytochrome P450 2C18 CYP2C18 0.0201
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
3815 Complement C1q subcomponent subunit A C1QA 0.0197
3816 Complement C1q subcomponent subunit B C1QB 0.0197
3817 Complement C1q subcomponent subunit C C1QC 0.0196
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0194
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0194
3814 Complement C1r subcomponent C1R 0.0194
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0194
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0194
766 Beta-2 adrenergic receptor ADRB2 0.0194
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0192
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0186
2112 Toll-like receptor 9 TLR9 0.0185
260 Cytochrome P450 51 ERG11 0.018
761 Cytochrome P450 51 ERG11 0.018
3163 Cytochrome P450 51 cyp51 0.018
1517 Beta-3 adrenergic receptor ADRB3 0.0178
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0177
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0176
824 Sodium-dependent serotonin transporter SLC6A4 0.0175
193 Beta-1 adrenergic receptor ADRB1 0.0174
492 Histamine H1 receptor HRH1 0.0172
3811 Cytochrome P450 19A1 CYP19A1 0.0169
1123 Eosinophil cationic protein RNASE3 0.0168
823 Fibroblast growth factor receptor 2 FGFR2 0.0158
3932 Glutathione S-transferase A2 GSTA2 0.0158
1789 Lymphotoxin-alpha LTA 0.0156
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0156
183 Vascular endothelial growth factor A VEGFA 0.0153
1654 Interleukin-1 beta IL1B 0.0149
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0144
244 Angiotensin-converting enzyme ACE 0.0141
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0138
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0137
494 Caspase-1 CASP1 0.0135
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0131
1507 Cytochrome c CYCS 0.0127
6143 Solute carrier family 22 member 7 SLC22A7 0.0124
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0124
6142 Solute carrier family 22 member 8 SLC22A8 0.0123
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0122
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.012
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0118
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0118
1898 Cytochrome P450 1B1 CYP1B1 0.0118
2077 Caspase-3 CASP3 0.0116
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0115
6144 Solute carrier family 22 member 2 SLC22A2 0.0112
1181 Alpha-1-acid glycoprotein 1 ORM1 0.011
556 Alpha-1A adrenergic receptor ADRA1A 0.011
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.011
1024 Solute carrier family 22 member 11 SLC22A11 0.0106
3941 Amine oxidase [flavin-containing] A MAOA 0.0106
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0105
502 5-hydroxytryptamine 2A receptor HTR2A 0.0105
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0103
22 30S ribosomal protein S4 rpsD 0.0103
6714 30S ribosomal protein S4 rpsD 0.0103
6145 Solute carrier family 22 member 1 SLC22A1 0.0102
862 Multidrug resistance-associated protein 1 ABCC1 0.01
468 Cytochrome P450 4A11 CYP4A11 0.0098
831 D(2) dopamine receptor DRD2 0.0097
275 Arachidonate 5-lipoxygenase ALOX5 0.0097
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0097
140 30S ribosomal protein S9 rpsI 0.0097
6719 30S ribosomal protein S9 rpsI 0.0097
6725 30S ribosomal protein S9 rpsI 0.0097
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0093
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0091
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0089
6201 Matrix metalloproteinase-27 MMP27 0.0087
23 D(1A) dopamine receptor DRD1 0.0087
6200 Matrix metalloproteinase-26 MMP26 0.0087
6197 Matrix metalloproteinase-23 MMP23A 0.0087
6199 Matrix metalloproteinase-25 MMP25 0.0087
6198 Matrix metalloproteinase-24 MMP24 0.0087
6192 Matrix metalloproteinase-15 MMP15 0.0087
6191 Matrix metalloproteinase-14 MMP14 0.0087
6196 Matrix metalloproteinase-21 MMP21 0.0087
6194 Matrix metalloproteinase-19 MMP19 0.0087
6193 Matrix metalloproteinase-17 MMP17 0.0087
6202 Matrix metalloproteinase-28 MMP28 0.0087
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0087
2970 Matrix metalloproteinase-16 MMP16 0.0085
6195 Matrix metalloproteinase-20 MMP20 0.0084
6188 Stromelysin-2 MMP10 0.0084
6190 Stromelysin-3 MMP11 0.0084
6031 Cytochrome P450 3A43 CYP3A43 0.0084
776 Bile salt export pump ABCB11 0.0084
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0084
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0083
3939 Amine oxidase [flavin-containing] B MAOB 0.0083
713 Sodium-dependent dopamine transporter SLC6A3 0.0082
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0082
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0081
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0081
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0078
731 HIV-1 protease HIV-1 protease 0.0078
6189 Matrilysin MMP7 0.0078
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0077
465 Calmodulin CALM1 0.0074
1167 Interstitial collagenase MMP1 0.0073
482 Glycine receptor subunit alpha-1 GLRA1 0.0072
632 Alpha-1B adrenergic receptor ADRA1B 0.0071
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0071
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0071
590 5-hydroxytryptamine 2C receptor HTR2C 0.0071
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0071
341 5-hydroxytryptamine 3 receptor HTR3A 0.0071
16 Adenosine A1 receptor ADORA1 0.007
320 5-hydroxytryptamine 1A receptor HTR1A 0.0069
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0068
2164 Multidrug resistance-associated protein 4 ABCC4 0.0067
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0065
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0065
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0064
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0062
1330 Collagenase 3 MMP13 0.0062
2154 Neutrophil collagenase MMP8 0.0062
2203 Macrophage metalloelastase MMP12 0.006
6102 Arylamine N-acetyltransferase 2 NAT2 0.0059
318 Alpha-2A adrenergic receptor ADRA2A 0.0059
537 ATP synthase delta chain, mitochondrial ATP5D 0.0059
6147 Solute carrier family 22 member 3 SLC22A3 0.0059
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0057
1926 Stromelysin-1 MMP3 0.0057
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0057
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0057
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0057
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0057
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0056
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0056
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0056
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0056
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0056
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0056
613 Atrial natriuretic peptide receptor A NPR1 0.0056
136 Estrogen receptor ESR1 0.0056
705 Glutamate receptor 1 GRIA1 0.0056
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0055
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0055
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0055
789 Alpha-1D adrenergic receptor ADRA1D 0.0055
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0055
1010 Cytochrome P450 51A1 CYP51A1 0.0054
122 P2Y purinoceptor 12 P2RY12 0.0053
817 DNA topoisomerase 2-alpha TOP2A 0.0052
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0052
885 5-hydroxytryptamine 1B receptor HTR1B 0.0051
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.005
444 Alcohol dehydrogenase 1B ADH1B 0.005
118 Organic cation/carnitine transporter 2 SLC22A5 0.0049
833 Organic cation/carnitine transporter 1 SLC22A4 0.0049
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0049
251 Alcohol dehydrogenase 1A ADH1A 0.0048
1178 Adenosine A2a receptor ADORA2A 0.0048
638 D(3) dopamine receptor DRD3 0.0048
146 Androgen receptor AR 0.0048
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0048
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0047
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0047
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0046
811 Translocator protein TSPO 0.0046
124 Histamine H2 receptor HRH2 0.0046
1757 Myeloperoxidase MPO 0.0046
6220 Aryl hydrocarbon receptor AHR 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
921 Glutamate receptor 2 GRIA2 0.0043
592 Carbonic anhydrase 4 CA4 0.0043
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0042
891 Dihydropteroate synthase folP 0.0042
5359 Dihydropteroate synthase folP 0.0042
7175 Dihydropteroate synthase sulI 0.0042
6014 Cytochrome P450 2A13 CYP2A13 0.0042
4604 Liver carboxylesterase 1 CES1 0.004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.004
94 5-hydroxytryptamine 4 receptor HTR4 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
4122 Histone deacetylase 2 HDAC2 0.0039
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0039
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
517 Alcohol dehydrogenase 1C ADH1C 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0036
725 5-hydroxytryptamine 1D receptor HTR1D 0.0036
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0036
6136 Multidrug resistance-associated protein 5 ABCC5 0.0035
153 Dopamine beta-hydroxylase DBH 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0034
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0034
6141 Sodium/bile acid cotransporter SLC10A1 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0034
373 Transthyretin TTR 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
4116 Dihydropteroate synthetase Not Available 0.0033
518 Peroxidase/catalase T katG 0.0033
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0033
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0033
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0033
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0032
3810 Catechol O-methyltransferase COMT 0.0032
362 Melatonin receptor type 1B MTNR1B 0.0032
571 Melatonin receptor type 1A MTNR1A 0.0032
432 D(4) dopamine receptor DRD4 0.0032
357 Carbonic anhydrase 2 CA2 0.0032
6148 Multidrug resistance-associated protein 7 ABCC10 0.0032
6182 Cytochrome P450 2J2 CYP2J2 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
563 Thyroid peroxidase TPO 0.0031
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0031
3923 Cholinesterase BCHE 0.003
295 Carbonic anhydrase 1 CA1 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0029
3947 Xanthine dehydrogenase/oxidase XDH 0.0029
436 5-hydroxytryptamine 2B receptor HTR2B 0.0029
6432 Transporter snf 0.0028
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0028
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
390 Adenosine A3 receptor ADORA3 0.0028
6137 Multidrug resistance-associated protein 6 ABCC6 0.0028
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0027
3404 Exotoxin A eta 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
49 Endothelin B receptor EDNRB 0.0027
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0026
3601 Dihydropteroate synthase 1 folP1 0.0026
3807 Dihydropteroate synthase 1 folP1 0.0026
3808 Dihydropteroate synthase 2 folP2 0.0026
716 5-hydroxytryptamine 7 receptor HTR7 0.0026
3937 Fatty-acid amide hydrolase FAAH 0.0026
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0026
904 Glutathione S-transferase P GSTP1 0.0026
85 Growth hormone receptor GHR 0.0025
365 Dihydrofolate reductase DHFR 0.0025
2381 Dihydrofolate reductase DFR1 0.0025
2833 Dihydrofolate reductase Not Available 0.0025
2931 Dihydrofolate reductase folA 0.0025
3544 Dihydrofolate reductase folA 0.0025
3682 Dihydrofolate reductase folA 0.0025
6642 Dihydrofolate reductase folA 0.0025
6756 Dihydrofolate reductase dfrA 0.0025
847 Mu-type opioid receptor OPRM1 0.0025
378 Alpha-2C adrenergic receptor ADRA2C 0.0025
578 Endothelin-1 receptor EDNRA 0.0025
3913 Glutamic acid decarboxylase GAD65 0.0024
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
380 Cytochrome P450 17A1 CYP17A1 0.0024
696 Kappa-type opioid receptor OPRK1 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0024
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
844 Epidermal growth factor receptor EGFR 0.0023
358 Cystathionine beta-synthase CBS 0.0023
319 Opioid receptor, sigma 1 OPRS1 0.0023
467 Delta-type opioid receptor OPRD1 0.0023
629 Alpha-2B adrenergic receptor ADRA2B 0.0023
1483 Membrane copper amine oxidase AOC3 0.0022
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0022
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0022
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0022
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
2539 Tubulin alpha-1 chain TUBA4A 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
4311 tRNA TRDMT1 0.0022
4325 tRNA trmD 0.0022
4328 tRNA trmD 0.0022
1192 Sulfotransferase 1A1 SULT1A1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
70 Type-1 angiotensin II receptor AGTR1 0.0022
976 Platelet glycoprotein IX GP9 0.0022
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0022
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0022
1256 5-hydroxytryptamine 6 receptor HTR6 0.0021
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
528 5-hydroxytryptamine 1E receptor HTR1E 0.0021
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0021
5300 Antigen peptide transporter 1 TAP1 0.0021
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0021
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0021
634 Squalene monooxygenase SQLE 0.002
7196 Squalene monooxygenase ERG1 0.002
735 Alanine aminotransferase 1 GPT 0.002
3904 Alanine aminotransferase 2 GPT2 0.002
2298 Cytochrome P450-cam camC 0.002
869 Estrogen receptor beta ESR2 0.002
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.002
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.002
3917 Methylenetetrahydrofolate reductase MTHFR 0.002
1618 High affinity nerve growth factor receptor NTRK1 0.002
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
174 Sigma 1-type opioid receptor SIGMAR1 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
1656 CYP2B protein CYP2B 0.0019
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0019
4120 NADPH--cytochrome P450 reductase POR 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0018
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0018
820 Glycine receptor subunit alpha-2 GLRA2 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
756 Sex hormone-binding globulin SHBG 0.0018
427 Substance-P receptor TACR1 0.0018
908 Glutathione S-transferase theta-1 GSTT1 0.0017
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0017
3809 Estrogen-related receptor gamma ESRRG 0.0017
6146 High affinity copper uptake protein 1 SLC31A1 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
871 Glucocorticoid receptor NR3C1 0.0017
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
163 D(1B) dopamine receptor DRD5 0.0016
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0015
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0015
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0015
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0015
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0015
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0015
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0015
7 Nitric oxide synthase, inducible NOS2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
29 Tubulin beta-1 chain TUBB1 0.0014
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0014
614 Progesterone receptor PGR 0.0014
6131 Carbonic anhydrase 14 CA14 0.0014
239 Coagulation factor X F10 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
1360 Sphingomyelin phosphodiesterase SMPD1 0.0013
228 Beta platelet-derived growth factor receptor PDGFRB 0.0013
106 Cannabinoid receptor 2 CNR2 0.0013
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0013
818 50S ribosomal protein L10 rplJ 0.0013
6174 50S ribosomal protein L32 rpmF 0.0013
6122 Carbonic anhydrase 3 CA3 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0013
4238 50S ribosomal protein L4 rplD 0.0013
5578 50S ribosomal protein L4 rplD 0.0013
6173 50S ribosomal protein L4 rplD 0.0013
6219 50S ribosomal protein L4 rplD 0.0013
1196 Complement decay-accelerating factor CD55 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
504 Mast/stem cell growth factor receptor KIT 0.0012
814 Ryanodine receptor 1 RYR1 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
68 Cannabinoid receptor 1 CNR1 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
84 Nuclear receptor 0B1 NR0B1 0.0012
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0012
3007 Carbonic anhydrase 12 CA12 0.0012
4205 Carbonic anhydrase 9 CA9 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0012
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0012
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0012
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0012
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0012
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0012
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
469 Annexin A1 ANXA1 0.0011
2808 Chloramphenicol acetyltransferase 3 cat3 0.0011
268 Adenosine A2b receptor ADORA2B 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
284 DNA-directed RNA polymerase beta chain rpoB 0.0011
5773 DNA-directed RNA polymerase beta chain rpoB 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0011
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0011
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
2417 Chloramphenicol acetyltransferase cat 0.001
3278 Chloramphenicol acetyltransferase cat 0.001
2810 Dr hemagglutinin structural subunit draA 0.001
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.001
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.001
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.001
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
581 Cytochrome P450 2R1 CYP2R1 0.001
6020 Aldehyde oxidase AOX1 0.001
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
997 Protein kinase C beta type PRKCB 0.0009
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
3830 Calreticulin CALR 0.0009
1275 Estrogen sulfotransferase SULT1E1 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1992 Vitamin D-binding protein GC 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
798 Osteocalcin BGLAP 0.0009
4192 DNA topoisomerase 2-beta TOP2B 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
3221 Cytochrome c4 cc4 0.0009
1050 Bile salt sulfotransferase SULT2A1 0.0009
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0008
1630 Integrin beta-2 ITGB2 0.0008
164 Histamine H4 receptor HRH4 0.0008
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0008
4102 Proteasome subunit beta type 5 PSMB5 0.0008
4101 Proteasome subunit beta type 1 PSMB1 0.0008
6459 Glycodelin PAEP 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
4217 Telomerase reverse transcriptase TERT 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
369 Coagulation factor VII F7 0.0008
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0008
511 5-hydroxytryptamine 1F receptor HTR1F 0.0008
896 Glutathione S-transferase Mu 1 GSTM1 0.0008
6085 Fatty acid-binding protein, intestinal FABP2 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
3957 Adenosine deaminase ADA 0.0007
2802 Endoglucanase G celCCG 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6044 Serum paraoxonase/lactonase 3 PON3 0.0007
2021 Thrombomodulin THBD 0.0007
33 Cystine/glutamate transporter SLC7A11 0.0007
856 Vitamin D3 receptor VDR 0.0007
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0006
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
572 Integrin alpha-L ITGAL 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
5798 Mitogen-activated protein kinase 11 MAPK11 0.0006
267 Plasminogen activator inhibitor 1 SERPINE1 0.0006
2320 Thymidine kinase, cytosolic TK1 0.0006
1864 RET proto-oncogene RET 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
2207 Rhodopsin RHO 0.0006
738 Monocarboxylate transporter 1 SLC16A1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6218 Pannexin-1 PANX1 0.0006
5934 Cytochrome P450 26A1 CYP26A1 0.0006
6221 Steroid hormone receptor ERR1 ESRRA 0.0006
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0006
1039 Histone deacetylase 9 HDAC9 0.0006
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0005
54 Prothrombin F2 0.0005
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0005
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
936 Ephrin type-A receptor 2 EPHA2 0.0005
165 FL cytokine receptor FLT3 0.0005
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0005
5787 Angiopoietin-1 receptor TEK 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
273 Apoptosis regulator Bcl-2 BCL2 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
6043 Putative G-protein coupled receptor 44 GPR44 0.0005
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0004
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
489 Monocarboxylate transporter 2 SLC16A7 0.0003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0003
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0003
↑