DT-Web

Interleukin-1 beta


Partner ID 1654
Name Interleukin-1 beta
Synonyms 3416
Gene name IL1B
General function Involved in growth factor activity
Specific function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells
Gene sequence + ...

ATGGCAGAAGTACCTAAGCTCGCCAGTGAAATGATGGCTTATTACAGTGGCAATGAGGATGACTTGTTCTTTGAAGCTGATGGCCCTAAACAGATGAAGTGCTCCTTCCAGGACCTGGACCTCTGCCCTCTGGATGGCGGCATCCAGCTACGAATCTCCGACCACCACTACAGCAAGGGCTTCAGGCAGGCCGCGTCAGTTGTTGTGGCCATGGACAAGCTGAGGAAGATGCTGGTTCCCTGCCCACAGACCTTCCAGGAGAATGACCTGAGCACCTTCTTTCCCTTCATCTTTGAAGAAGAACCTATCTTCTTCGACACATGGGATAACGAGGCTTATGTGCACGATGCACCTGTACGATCACTGAACTGCACGCTCCGGGACTCACAGCAAAAAAGCTTGGTGATGTCTGGTCCATATGAACTGAAAGCTCTCCACCTCCAGGGACAGGATATGGAGCAACAAGTGGTGTTCTCCATGTCCTTTGTACAAGGAGAAGAAAGTAATGACAAAATACCTGTGGCCTTGGGCCTCAAGGAAAAGAATCTGTACCTGTCCTGCGTGTTGAAAGATGATAAGCCCACTCTACAGCTGGAGAGTGTAGATCCCAAAAATTACCCAAAGAAGAAGATGGAAAAGCGATTTGTCTTCAACAAGATAGAAATCAATAACAAGCTGGAATTTGAGTCTGCCCAGTTCCCCAACTGGTACATCAGCACCTCTCAAGCAGAAAACATGCCCGTCTTCCTGGGAGGGACCAAAGGCGGCCAGGATATAACTGACTTCACCATGCAATTTGTGTCTTCCTAA
Protein sequence + ...

MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKGFRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
GO Classification
component
extracellular region
function
interleukin-1 receptor binding
signal transducer activity
growth factor activity
receptor binding
cytokine activity
process
immune response
inflammatory response
response to stimulus
response to biotic stimulus
defense response
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB01017 Minocycline
DB05260 Gallium nitrate
DB06168 Canakinumab
DB06372 Rilonacept

Associated as Prediction

Id Name
DB00091 Cyclosporine
DB00112 Bevacizumab
DB00139 Succinic acid
DB00140 Riboflavin
DB00158 Folic Acid
DB00163 Vitamin E
DB00168 Aspartame
DB00170 Menadione
DB00175 Pravastatin
DB00179 Masoprocol
DB00181 Baclofen
DB00198 Oseltamivir
DB00199 Erythromycin
DB00229 Cefotiam
DB00233 Aminosalicylic Acid
DB00242 Cladribine
DB00244 Mesalazine
DB00254 Doxycycline
DB00256 Lymecycline
DB00277 Theophylline
DB00279 Liothyronine
DB00286 Conjugated Estrogens
DB00300 Tenofovir
DB00311 Ethoxzolamide
DB00313 Valproic Acid
DB00316 Acetaminophen
DB00319 Piperacillin
DB00328 Indomethacin
DB00345 Aminohippurate
DB00365 Grepafloxacin
DB00369 Cidofovir
DB00390 Digoxin
DB00432 Trifluridine
DB00437 Allopurinol
DB00438 Ceftazidime
DB00446 Chloramphenicol
DB00453 Clomocycline
DB00456 Cefalotin
DB00469 Tenoxicam
DB00471 Montelukast
DB00493 Cefotaxime
DB00495 Zidovudine
DB00500 Tolmetin
DB00501 Cimetidine
DB00512 Vancomycin
DB00520 Caspofungin
DB00529 Foscarnet
DB00536 Guanidine
DB00544 Fluorouracil
DB00554 Piroxicam
DB00560 Tigecycline
DB00563 Methotrexate
DB00567 Cephalexin
DB00577 Valaciclovir
DB00578 Carbenicillin
DB00583 L-Carnitine
DB00584 Enalapril
DB00586 Diclofenac
DB00595 Oxytetracycline
DB00605 Sulindac
DB00606 Cyclothiazide
DB00607 Nafcillin
DB00618 Demeclocycline
DB00624 Testosterone
DB00649 Stavudine
DB00672 Chlorpropamide
DB00678 Losartan
DB00693 Fluorescein
DB00695 Furosemide
DB00703 Methazolamide
DB00709 Lamivudine
DB00711 Diethylcarbamazine
DB00712 Flurbiprofen
DB00718 Adefovir Dipivoxil
DB00731 Nateglinide
DB00744 Zileuton
DB00749 Etodolac
DB00759 Tetracycline
DB00779 Nalidixic Acid
DB00783 Estradiol
DB00786 Marimastat
DB00787 Acyclovir
DB00788 Naproxen
DB00795 Sulfasalazine
DB00798 Gentamicin
DB00812 Phenylbutazone
DB00819 Acetazolamide
DB00821 Carprofen
DB00827 Cinoxacin
DB00861 Diflunisal
DB00863 Ranitidine
DB00880 Chlorothiazide
DB00887 Bumetanide
DB00893 Iron Dextran
DB00900 Didanosine
DB00903 Ethacrynic acid
DB00908 Quinidine
DB00917 Dinoprostone
DB00927 Famotidine
DB00936 Salicyclic acid
DB00939 Meclofenamic acid
DB00943 Zalcitabine
DB00945 Acetylsalicylic acid
DB00999 Hydrochlorothiazide
DB01004 Ganciclovir
DB01009 Ketoprofen
DB01014 Balsalazide
DB01016 Glyburide
DB01017 Minocycline
DB01022 Phytonadione
DB01032 Probenecid
DB01033 Mercaptopurine
DB01045 Rifampin
DB01050 Ibuprofen
DB01051 Novobiocin
DB01053 Penicillin G
DB01059 Norfloxacin
DB01060 Amoxicillin
DB01065 Melatonin
DB01082 Streptomycin
DB01092 Ouabain
DB01120 Gliclazide
DB01124 Tolbutamide
DB01136 Carvedilol
DB01137 Levofloxacin
DB01140 Cefadroxil
DB01147 Cloxacillin
DB01160 Dinoprost Tromethamine
DB01165 Ofloxacin
DB01197 Captopril
DB01211 Clarithromycin
DB01212 Ceftriaxone
DB01237 Bromodiphenhydramine
DB01248 Docetaxel
DB01270 Ranibizumab
DB01294 Bismuth Subsalicylate
DB01296 Glucosamine
DB01301 Rolitetracycline
DB01303 Oxtriphylline
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB01333 Cefradine
DB01370 Aluminium
DB01414 Cefacetrile
DB01424 Aminophenazone
DB01435 Antipyrine
DB01583 Liotrix
DB01597 Cilastatin
DB01650 trans-2-hydroxycinnamic acid
DB01892 Hyperforin
DB01949 2-Amino-N,3,3-Trimethylbutanamide
DB02110 Protoporphyrin Ix Containing Co
DB02266 Flufenamic Acid
DB02315 Cyclic Guanosine Monophosphate
DB02527 Cyclic Adenosine Monophosphate
DB02659 Cholic Acid
DB03014 Heme
DB03088 Pyroglutamic Acid
DB03124 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
DB03317 Heme C
DB03553 Glutaric Acid
DB03585 Oxyphenbutazone
DB03683 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid
DB03754 Tris(Hydroxymethyl)Aminomethane
DB03783 Phenacetin
DB03793 Benzoic Acid
DB03847 Gamma-Carboxy-Glutamic Acid
DB03902 Oxalic Acid
DB03934 Protoporphyrin Ix Containing Zn
DB03977 N-Trimethyllysine
DB04133 Degraded Cephaloridine
DB04249 Zinc Substituted Heme C
DB04348 Taurocholic Acid
DB04519 Caprylic acid
DB05260 Gallium nitrate
DB05294 Vandetanib
DB06151 Acetylcysteine
DB06168 Canakinumab
DB06335 Saxagliptin
DB06372 Rilonacept
DB06710 Methyltestosterone
DB06779 Dalteparin
DB06862 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
DB07117 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE
DB07246 (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE
DB07285 (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID
DB07347 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE
DB07696 methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
DB07733 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE
DB07744 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID
DB07916 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
DB08213 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
DB08229 [N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL)-HYDRAZINO]-ACETIC ACID
DB08251 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
DB08497 (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
DB08498 (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
DB08499 N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
DB08837 Tetraethylammonium
DB08846 Ellagic Acid
DB08885 Aflibercept
DB08912 Dabrafenib
↑