DT-Web

DB04348 - Taurocholic Acid


Identification
Name Taurocholic Acid
Accession Number DB04348 (EXPT03023)
Type small molecule
Description The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 515.703
Groups experimental
Monoisotopic Weight 515.291673489
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Bile salt-activated lipase
Name Bile salt-activated lipase
Gene Name CEL
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Gastrotropin
Name Gastrotropin
Gene Name FABP6
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3689

Transporters


Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions substrate,inducer
References
  • Hartmann G, Cheung AK, Piquette-Miller M: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. - Pubmed
  • Wolters H, Elzinga BM, Baller JF, Boverhof R, Schwarz M, Stieger B, Verkade HJ, Kuipers F: Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice. J Hepatol. 2002 Nov;37(5):556-63. - Pubmed
  • Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF, Linton KJ, Thompson RJ: The human bile salt export pump: characterization of substrate specificity and identification of inhibitors. Gastroenterology. 2002 Nov;123(5):1649-58. - Pubmed
  • Noe J, Hagenbuch B, Meier PJ, St-Pierre MV: Characterization of the mouse bile salt export pump overexpressed in the baculovirus system. Hepatology. 2001 May;33(5):1223-31. - Pubmed
  • Mendoza ME, Monte MJ, Serrano MA, Pastor-Anglada M, Stieger B, Meier PJ, Medarde M, Marin JJ: Physiological characteristics of allo-cholic acid. J Lipid Res. 2003 Jan;44(1):84-92. - Pubmed
  • Green RM, Hoda F, Ward KL: Molecular cloning and characterization of the murine bile salt export pump. Gene. 2000 Jan 4;241(1):117-23. - Pubmed
  • Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
  • Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, Meier PJ: The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem. 1998 Apr 17;273(16):10046-50. - Pubmed
  • Funk C, Pantze M, Jehle L, Ponelle C, Scheuermann G, Lazendic M, Gasser R: Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate. Toxicology. 2001 Oct 5;167(1):83-98. - Pubmed
  • Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H, Sugiyama Y: Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim Biophys Acta. 2001 Mar 9;1511(1):7-16. - Pubmed
  • Madon J, Hagenbuch B, Landmann L, Meier PJ, Stieger B: Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol. 2000 Mar;57(3):634-41. - Pubmed
  • Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5. - Pubmed
DTHybrid score 0.5193
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor,inducer
References
  • Hartmann G, Cheung AK, Piquette-Miller M: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. - Pubmed
  • Heijn M, Hooijberg JH, Scheffer GL, Szabo G, Westerhoff HV, Lankelma J: Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport. Biochim Biophys Acta. 1997 May 22;1326(1):12-22. - Pubmed
DTHybrid score 0.5275
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions substrate,inhibitor,inducer
References
  • Hartmann G, Cheung AK, Piquette-Miller M: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. - Pubmed
  • Wolters H, Elzinga BM, Baller JF, Boverhof R, Schwarz M, Stieger B, Verkade HJ, Kuipers F: Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice. J Hepatol. 2002 Nov;37(5):556-63. - Pubmed
  • van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ: Comparison of - type I
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ: Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. - Pubmed
  • Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ: Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology. 1994 Aug;20(2):411-6. - Pubmed
  • Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. - Pubmed
  • Bossuyt X, Muller M, Hagenbuch B, Meier PJ: Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J Pharmacol Exp Ther. 1996 Mar;276(3):891-6. - Pubmed
  • Kontaxi M, Echkardt U, Hagenbuch B, Stieger B, Meier PJ, Petzinger E: Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J Pharmacol Exp Ther. 1996 Dec;279(3):1507-13. - Pubmed
  • Li L, Lee TK, Meier PJ, Ballatori N: Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. J Biol Chem. 1998 Jun 26;273(26):16184-91. - Pubmed
  • Pang KS, Wang PJ, Chung AY, Wolkoff AW: The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology. 1998 Nov;28(5):1341-6. - Pubmed
  • van Montfoort JE, Stieger B, Meijer DK, Weinmann HJ, Meier PJ, Fattinger KE: Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. J Pharmacol Exp Ther. 1999 Jul;290(1):153-7. - Pubmed
  • Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. - Pubmed
  • Kullak-Ublick GA, Beuers U, Paumgartner G: Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells. Hepatology. 1996 May;23(5):1053-60. - Pubmed
  • Hagenbuch B, Adler ID, Schmid TE: Molecular cloning and functional characterization of the mouse organic-anion-transporting polypeptide 1 (Oatp1) and mapping of the gene to chromosome X. Biochem J. 2000 Jan 1;345 Pt 1:115-20. - Pubmed
  • Mendoza ME, Monte MJ, Serrano MA, Pastor-Anglada M, Stieger B, Meier PJ, Medarde M, Marin JJ: Physiological characteristics of allo-cholic acid. J Lipid Res. 2003 Jan;44(1):84-92. - Pubmed
  • Lee TK, Koh AS, Cui Z, Pierce RH, Ballatori N: N-glycosylation controls functional activity of Oatp1, an organic anion transporter. Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G371-81. Epub 2003 Apr 17. - Pubmed
  • Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW: Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G829-39. Epub 2003 Jul 3. - Pubmed
  • Kanai N, Lu R, Bao Y, Wolkoff AW, Vore M, Schuster VL: Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am J Physiol. 1996 Feb;270(2 Pt 2):F326-31. - Pubmed
  • Satlin LM, Amin V, Wolkoff AW: Organic anion transporting polypeptide mediates organic anion/HCO3- exchange. J Biol Chem. 1997 Oct 17;272(42):26340-5. - Pubmed
  • Kouzuki H, Suzuki H, Ito K, Ohashi R, Sugiyama Y: Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes. J Pharmacol Exp Ther. 1999 Feb;288(2):627-34. - Pubmed
  • Eckhardt U, Schroeder A, Stieger B, Hochli M, Landmann L, Tynes R, Meier PJ, Hagenbuch B: Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am J Physiol. 1999 Apr;276(4 Pt 1):G1037-42. - Pubmed
DTHybrid score 0.8533
Ileal sodium/bile acid cotransporter
Name Ileal sodium/bile acid cotransporter
Gene Name SLC10A2
Actions substrate,inducer
References
  • Wolters H, Elzinga BM, Baller JF, Boverhof R, Schwarz M, Stieger B, Verkade HJ, Kuipers F: Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice. J Hepatol. 2002 Nov;37(5):556-63. - Pubmed
  • Hallen S, Bjorquist A, Ostlund-Lindqvist AM, Sachs G: Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. Biochemistry. 2002 Dec 17;41(50):14916-24. - Pubmed
  • Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. - Pubmed
  • Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, Dawson PA: Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69. - Pubmed
  • Saeki T, Matoba K, Furukawa H, Kirifuji K, Kanamoto R, Iwami K: Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter. J Biochem. 1999 Apr;125(4):846-51. - Pubmed
  • Saeki T, Takahashi N, Kanamoto R, Iwami K: Characterization of cloned mouse Na+/taurocholate cotransporting polypeptide by transient expression in COS-7 cells. Biosci Biotechnol Biochem. 2002 May;66(5):1116-8. - Pubmed
  • Lazaridis KN, Tietz P, Wu T, Kip S, Dawson PA, LaRusso NF: Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11092-7. - Pubmed
  • Walters HC, Craddock AL, Fusegawa H, Willingham MC, Dawson PA: Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1188-200. - Pubmed
DTHybrid score 0.4304
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Hartmann G, Cheung AK, Piquette-Miller M: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. - Pubmed
DTHybrid score 0.646
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions substrate,inhibitor,inducer
References
  • Hartmann G, Cheung AK, Piquette-Miller M: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. - Pubmed
  • Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A: Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. J Pharm Pharmacol. 2003 Jul;55(7):1013-20. - Pubmed
  • Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, Kirchgessner TG: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem. 1999 Dec 24;274(52):37161-8. - Pubmed
  • Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. - Pubmed
  • Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H: Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. - Pubmed
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score 0.7954
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed
DTHybrid score 0.4158
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions substrate,inhibitor
References
  • Zeng H, Chen ZS, Belinsky MG, Rea PA, Kruh GD: Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32. - Pubmed
  • Zelcer N, Saeki T, Bot I, Kuil A, Borst P: Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter. Biochem J. 2003 Jan 1;369(Pt 1):23-30. - Pubmed
  • Zhang DW, Gu HM, Vasa M, Muredda M, Cole SP, Deeley RG: Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. Biochemistry. 2003 Aug 26;42(33):9989-10000. - Pubmed
  • Hirohashi T, Suzuki H, Takikawa H, Sugiyama Y: ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem. 2000 Jan 28;275(4):2905-10. - Pubmed
  • Li T, Ito K, Horie T: Transport of fluorescein methotrexate by multidrug resistance-associated protein 3 in IEC-6 cells. Am J Physiol Gastrointest Liver Physiol. 2003 Sep;285(3):G602-10. - Pubmed
  • Akita H, Suzuki H, Hirohashi T, Takikawa H, Sugiyama Y: Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3. Pharm Res. 2002 Jan;19(1):34-41. - Pubmed
DTHybrid score 0.405
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Zelcer N, Reid G, Wielinga P, Kuil A, van der Heijden I, Schuetz JD, Borst P: Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7. - Pubmed
DTHybrid score 0.5332
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Mazzanti R, Fantappie O, Kamimoto Y, Gatmaitan Z, Gentilini P, Arias IM: Bile acid inhibition of P-glycoprotein-mediated transport in multidrug-resistant cells and rat liver canalicular membrane vesicles. Hepatology. 1994 Jul;20(1 Pt 1):170-6. - Pubmed
  • Lecureur V, Sun D, Hargrove P, Schuetz EG, Kim RB, Lan LB, Schuetz JD: Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Mol Pharmacol. 2000 Jan;57(1):24-35. - Pubmed
DTHybrid score 0.7904
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions substrate,inhibitor
References
  • Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed
  • Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK: Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26;277(30):26934-43. Epub 2002 May 13. - Pubmed
  • Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem. 1997 Jul 25;272(30):18526-9. - Pubmed
DTHybrid score 0.6833
Multidrug resistance-associated protein 7
Name Multidrug resistance-associated protein 7
Gene Name ABCC10
Actions inhibitor
References
  • Chen ZS, Hopper-Borge E, Belinsky MG, Shchaveleva I, Kotova E, Kruh GD: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol Pharmacol. 2003 Feb;63(2):351-8. - Pubmed
DTHybrid score 0.2776
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate,inhibitor
References
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
  • Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed
  • Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
  • Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, Sugiyama Y: Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther. 2001 Jul;298(1):316-22. - Pubmed
  • Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK: Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002 Jul 26;277(30):26934-43. Epub 2002 May 13. - Pubmed
DTHybrid score 0.6738
Solute carrier organic anion transporter family member 4A1
Name Solute carrier organic anion transporter family member 4A1
Gene Name SLCO4A1
Actions inhibitor
References
  • Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M, Onogawa T, Suzuki T, Asano N, Tanemoto M, Seki M, Shiiba K, Suzuki M, Kondo Y, Nunoki K, Shimosegawa T, Iinuma K, Ito S, Matsuno S, Abe T: Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12. - Pubmed
DTHybrid score 0.4033
ATP-binding cassette transporter sub-family C member 11
Name ATP-binding cassette transporter sub-family C member 11
Gene Name ABCC11
Actions inhibitor
References
  • Chen ZS, Guo Y, Belinsky MG, Kotova E, Kruh GD: Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol. 2005 Feb;67(2):545-57. Epub 2004 Nov 10. - Pubmed
DTHybrid score 0.2879
Solute carrier organic anion transporter family member 1C1
Name Solute carrier organic anion transporter family member 1C1
Gene Name SLCO1C1
Actions substrate,inhibitor
References
  • Tohyama K, Kusuhara H, Sugiyama Y: Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier. Endocrinology. 2004 Sep;145(9):4384-91. Epub 2004 May 27. - Pubmed
  • Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score 0.4336
Solute carrier organic anion transporter family member 3A1
Name Solute carrier organic anion transporter family member 3A1
Gene Name SLCO3A1
Actions inhibitor
References
  • Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, Satoh F, Suzuki M, Tokui T, Unno M, Shimosegawa T, Matsuno S, Ito S, Abe T: Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. - Pubmed
DTHybrid score 0.3545
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Imai Y, Asada S, Tsukahara S, Ishikawa E, Tsuruo T, Sugimoto Y: Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol. 2003 Sep;64(3):610-8. - Pubmed
DTHybrid score 0.5808
Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions substrate
References
  • Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I: Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45. Epub 2003 Nov 10. - Pubmed
  • Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. - Pubmed
  • Nishio T, Adachi H, Nakagomi R, Tokui T, Sato E, Tanemoto M, Fujiwara K, Okabe M, Onogawa T, Suzuki T, Nakai D, Shiiba K, Suzuki M, Ohtani H, Kondo Y, Unno M, Ito S, Iinuma K, Nunoki K, Matsuno S, Abe T: Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Biochem Biophys Res Commun. 2000 Sep 7;275(3):831-8. - Pubmed
DTHybrid score 0.5852
Monocarboxylate transporter 1
Name Monocarboxylate transporter 1
Gene Name SLC16A1
Actions substrate
References
  • Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A: Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol. 1999 Oct;51(10):1113-21. - Pubmed
DTHybrid score 0.3936
Sodium/bile acid cotransporter
Name Sodium/bile acid cotransporter
Gene Name SLC10A1
Actions substrate
References
  • Mendoza ME, Monte MJ, Serrano MA, Pastor-Anglada M, Stieger B, Meier PJ, Medarde M, Marin JJ: Physiological characteristics of allo-cholic acid. J Lipid Res. 2003 Jan;44(1):84-92. - Pubmed
  • Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW: Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G829-39. Epub 2003 Jul 3. - Pubmed
  • Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5. - Pubmed
  • Boyer JL, Ng OC, Ananthanarayanan M, Hofmann AF, Schteingart CD, Hagenbuch B, Stieger B, Meier PJ: Expression and characterization of a functional rat liver Na+ bile acid cotransport system in COS-7 cells. Am J Physiol. 1994 Mar;266(3 Pt 1):G382-7. - Pubmed
DTHybrid score 0.5001
Organic solute transporter subunit alpha
Name Organic solute transporter subunit alpha
Gene Name OSTA
Actions substrate
References
  • Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. - Pubmed
DTHybrid score 0.3116
Organic solute transporter subunit beta
Name Organic solute transporter subunit beta
Gene Name OSTB
Actions substrate
References
  • Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. - Pubmed
DTHybrid score 0.3117
Solute carrier organic anion transporter family member 1B3
Name Solute carrier organic anion transporter family member 1B3
Gene Name SLCO1B3
Actions substrate
References
  • Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. - Pubmed
  • Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
  • Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, Matsuno S: LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. - Pubmed
DTHybrid score 0.644
Cystine/glutamate transporter
Name Cystine/glutamate transporter
Gene Name SLC7A11
Actions Not Available
References
  • Hagenbuch B, Meier PJ: Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J Clin Invest. 1994 Mar;93(3):1326-31. - Pubmed
DTHybrid score 0.3569

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.4944
1024 Solute carrier family 22 member 11 SLC22A11 0.3282
4757 Cytochrome P450 2C9 CYP2C9 0.3231
4924 Cytochrome P450 2C8 CYP2C8 0.3138
587 Serum albumin ALB 0.2887
6143 Solute carrier family 22 member 7 SLC22A7 0.2818
4118 Cytochrome P450 3A5 CYP3A5 0.2795
4200 Cytochrome P450 1A2 CYP1A2 0.2613
6016 Cytochrome P450 2C19 CYP2C19 0.2443
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.225
6144 Solute carrier family 22 member 2 SLC22A2 0.2153
4119 Cytochrome P450 2D6 CYP2D6 0.2095
6107 Cytochrome P450 3A7 CYP3A7 0.1904
6136 Multidrug resistance-associated protein 5 ABCC5 0.1755
118 Organic cation/carnitine transporter 2 SLC22A5 0.1628
6024 Cytochrome P450 1A1 CYP1A1 0.1518
489 Monocarboxylate transporter 2 SLC16A7 0.145
6030 Cytochrome P450 2B6 CYP2B6 0.1336
20 Prostaglandin G/H synthase 1 PTGS1 0.1336
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.1269
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.1264
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.123
290 Prostaglandin G/H synthase 2 PTGS2 0.123
6013 Cytochrome P450 2E1 CYP2E1 0.1222
758 Thyroid hormone receptor alpha THRA 0.1171
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1128
6149 Solute carrier family 22 member 10 SLC22A10 0.1116
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.1046
6137 Multidrug resistance-associated protein 6 ABCC6 0.1042
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.1038
136 Estrogen receptor ESR1 0.1034
833 Organic cation/carnitine transporter 1 SLC22A4 0.1018
6147 Solute carrier family 22 member 3 SLC22A3 0.1011
1898 Cytochrome P450 1B1 CYP1B1 0.1007
346 Thyroid hormone receptor beta-1 THRB 0.1003
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.097
500 Monocarboxylate transporter 4 SLC16A3 0.0967
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0933
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0933
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0908
594 Thyroxine-binding globulin SERPINA7 0.09
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0891
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0857
1650 Heme carrier protein 1 SLC46A1 0.0831
338 DNA polymerase UL30 0.0809
379 DNA polymerase UL54 0.0809
697 DNA polymerase ORF28 0.0809
2482 DNA polymerase 43 0.0809
4104 DNA polymerase BALF5 0.0809
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0802
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0786
6151 Monocarboxylate transporter 10 SLC16A10 0.0777
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0725
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0711
293 Gamma-glutamyl hydrolase GGH 0.0706
817 DNA topoisomerase 2-alpha TOP2A 0.0704
3811 Cytochrome P450 19A1 CYP19A1 0.0681
373 Transthyretin TTR 0.0681
5718 Cytochrome P450 2A6 CYP2A6 0.0668
24 Thymidylate synthase TMP1 0.0662
359 Thymidylate synthase TYMS 0.0662
2626 Thymidylate synthase thyA 0.0662
2729 Thymidylate synthase thyA 0.0662
5352 Thymidylate synthase THYA 0.0662
4604 Liver carboxylesterase 1 CES1 0.0652
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0634
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0623
3917 Methylenetetrahydrofolate reductase MTHFR 0.059
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0573
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0555
70 Type-1 angiotensin II receptor AGTR1 0.0553
275 Arachidonate 5-lipoxygenase ALOX5 0.0536
3810 Catechol O-methyltransferase COMT 0.0529
5626 Nucleoside diphosphate kinase B NME2 0.0528
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0525
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0516
199 Monocarboxylate transporter 8 SLC16A2 0.0509
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0487
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0486
38 Cystinosin CTNS 0.0485
2391 Ferrochelatase hemH 0.0485
6502 Ferrochelatase DKFZp686P18130 0.0485
1591 Ferrochelatase, mitochondrial FECH 0.0485
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0485
6106 Cytochrome P450 2C18 CYP2C18 0.0479
672 Prostaglandin F2-alpha receptor PTGFR 0.0474
731 HIV-1 protease HIV-1 protease 0.0446
29 Tubulin beta-1 chain TUBB1 0.0433
4773 Deoxycytidine kinase DCK 0.0431
5818 Folate receptor alpha FOLR1 0.0428
527 Prostacyclin receptor PTGIR 0.0427
5294 Nucleoside diphosphate kinase A NME1 0.0425
6599 HTH-type transcriptional regulator ttgR ttgR 0.0422
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0422
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0419
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0419
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0419
6493 Cytochrome c oxidase subunit 6C COX6C 0.0419
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0419
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0419
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0419
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0419
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0419
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0418
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0418
6559 Cytochrome c oxidase subunit 2 ctaC 0.0418
6669 Cytochrome c oxidase subunit 2 ctaC 0.0418
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0418
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0418
6558 Cytochrome c oxidase subunit 1 ctaD 0.0418
3947 Xanthine dehydrogenase/oxidase XDH 0.0406
6085 Fatty acid-binding protein, intestinal FABP2 0.0406
3685 Catabolite gene activator crp 0.0389
4655 Adenylate cyclase cyaC 0.0389
4759 Adenylate cyclase cyaB2 0.0389
2540 Choloylglycine hydrolase cbh 0.0386
273 Apoptosis regulator Bcl-2 BCL2 0.0384
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0384
718 Folate receptor gamma FOLR3 0.0383
299 Folate receptor beta FOLR2 0.0383
804 Mitochondrial folate transporter/carrier SLC25A32 0.0383
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0382
6500 Phospholipase A2 PLA2G1B 0.038
756 Sex hormone-binding globulin SHBG 0.0376
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0372
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0365
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0365
6501 Fatty acid-binding protein, liver FABP1 0.0362
3809 Estrogen-related receptor gamma ESRRG 0.0358
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0358
2539 Tubulin alpha-1 chain TUBA4A 0.0357
6020 Aldehyde oxidase AOX1 0.0355
6218 Pannexin-1 PANX1 0.0352
5923 Microtubule-associated protein tau MAPT 0.0344
5924 Microtubule-associated protein 4 MAP4 0.0344
404 DNA gyrase subunit A gyrA 0.0342
6224 DNA gyrase subunit A gyrA 0.0342
904 Glutathione S-transferase P GSTP1 0.0341
869 Estrogen receptor beta ESR2 0.0337
468 Cytochrome P450 4A11 CYP4A11 0.0334
4760 Mll3241 protein mll3241 0.0334
161 Tubulin beta chain TUBB 0.0333
312 Tubulin beta chain TUB2 0.0333
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0333
1852 Microtubule-associated protein 2 MAP2 0.0332
492 Histamine H1 receptor HRH1 0.0332
563 Thyroid peroxidase TPO 0.0319
556 Alpha-1A adrenergic receptor ADRA1A 0.03
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.03
1792 Tissue-type plasminogen activator PLAT 0.0293
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0286
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0286
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0282
4120 NADPH--cytochrome P450 reductase POR 0.0278
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0277
509 Thymidine kinase TK 0.0276
570 Thymidine kinase TK 0.0276
2559 Thymidine kinase TK 0.0276
3430 Thymidine kinase tdk 0.0276
3518 Thymidine kinase TK 0.0276
5301 Thymidine kinase tdk 0.0276
5771 Thymidine kinase ORF36 0.0276
7009 Thymidine kinase ORF36 0.0276
320 5-hydroxytryptamine 1A receptor HTR1A 0.0275
908 Glutathione S-transferase theta-1 GSTT1 0.0272
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0271
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0271
477 DNA topoisomerase 4 subunit A parC 0.027
886 DNA topoisomerase 4 subunit A parC 0.027
6226 DNA topoisomerase 4 subunit A parC 0.027
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0269
702 UMP-CMP kinase CMPK1 0.0263
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0262
4192 DNA topoisomerase 2-beta TOP2B 0.026
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0257
3923 Cholinesterase BCHE 0.0257
887 DNA gyrase subunit B gyrB 0.0255
4150 DNA gyrase subunit B gyrB 0.0255
6225 DNA gyrase subunit B gyrB 0.0255
517 Alcohol dehydrogenase 1C ADH1C 0.0254
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0253
380 Cytochrome P450 17A1 CYP17A1 0.0251
504 Mast/stem cell growth factor receptor KIT 0.0249
871 Glucocorticoid receptor NR3C1 0.0248
2929 (S)-2-haloacid dehalogenase dhlB 0.0248
2995 (S)-2-haloacid dehalogenase Not Available 0.0248
3611 Cytidine deaminase cdd 0.0247
3707 Cytidine deaminase cdd 0.0247
4211 Cytidine deaminase CDA 0.0247
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0247
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0243
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.024
5650 NimA-related protein DR_0842 0.024
6171 Solute carrier family 28 member 3 SLC28A3 0.0239
6031 Cytochrome P450 3A43 CYP3A43 0.0235
1353 DNA topoisomerase 1 TOP1 0.0235
3552 DNA topoisomerase 1 topA 0.0235
365 Dihydrofolate reductase DHFR 0.0235
2381 Dihydrofolate reductase DFR1 0.0235
2833 Dihydrofolate reductase Not Available 0.0235
2931 Dihydrofolate reductase folA 0.0235
3544 Dihydrofolate reductase folA 0.0235
3682 Dihydrofolate reductase folA 0.0235
6642 Dihydrofolate reductase folA 0.0235
6756 Dihydrofolate reductase dfrA 0.0235
2981 Phospholipase A2, membrane associated PLA2G2A 0.0234
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0234
831 D(2) dopamine receptor DRD2 0.0232
244 Angiotensin-converting enzyme ACE 0.0232
6042 Prostaglandin reductase 2 PTGR2 0.0232
6043 Putative G-protein coupled receptor 44 GPR44 0.0231
723 Cytosolic phospholipase A2 PLA2G4A 0.0229
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0226
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0223
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0223
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0218
844 Epidermal growth factor receptor EGFR 0.0216
645 Penicillin-binding protein 1A mrcA 0.0212
5805 Penicillin-binding protein 1A ponA 0.0212
6185 Penicillin-binding protein 1A mrcA 0.0212
6799 Penicillin-binding protein 1A pbpA 0.0212
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0212
1313 Lactoylglutathione lyase GLO1 0.0211
117 Sterol O-acyltransferase 1 SOAT1 0.0211
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.021
737 Mineralocorticoid receptor NR3C2 0.0209
32 Vascular endothelial growth factor receptor 1 FLT1 0.0209
614 Progesterone receptor PGR 0.0205
124 Histamine H2 receptor HRH2 0.0204
824 Sodium-dependent serotonin transporter SLC6A4 0.0203
407 Vascular endothelial growth factor receptor 2 KDR 0.0201
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.02
146 Androgen receptor AR 0.0199
228 Beta platelet-derived growth factor receptor PDGFRB 0.0199
558 Solute carrier family 12 member 1 SLC12A1 0.0198
2016 Dipeptidase 1 DPEP1 0.0197
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0196
633 Penicillin-binding proteins 1A/1B pbpA 0.0195
502 5-hydroxytryptamine 2A receptor HTR2A 0.0193
2808 Chloramphenicol acetyltransferase 3 cat3 0.0192
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0191
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0191
543 Penicillin-binding protein 1B mrcB 0.019
6186 Penicillin-binding protein 1B ponB 0.019
6822 Penicillin-binding protein 1b pbp1b 0.019
6844 Penicillin-binding protein 1b pbp1b 0.019
950 Alpha platelet-derived growth factor receptor PDGFRA 0.019
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0186
3941 Amine oxidase [flavin-containing] A MAOA 0.0186
683 Potassium transporter GK0582 0.0185
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0185
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0184
860 Nicotinamide N-methyltransferase NNMT 0.0183
928 Nicotinic acid receptor 2 GPR109B 0.0183
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0183
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0183
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0183
699 Nicotinic acid receptor 1 GPR109A 0.0183
952 Dipeptidyl peptidase 4 DPP4 0.0183
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0182
23 D(1A) dopamine receptor DRD1 0.0182
3270 Elongation factor G fusA 0.0181
632 Alpha-1B adrenergic receptor ADRA1B 0.0179
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0178
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0177
2508 Cyclomaltodextrin glucanotransferase cgt 0.0177
2523 Cyclomaltodextrin glucanotransferase cgt 0.0177
3207 Cyclomaltodextrin glucanotransferase amyA 0.0177
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0175
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0175
22 30S ribosomal protein S4 rpsD 0.0173
6714 30S ribosomal protein S4 rpsD 0.0173
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0173
6837 Serine/threonine-protein kinase 17B STK17B 0.017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.017
6168 Solute carrier family 22 member 16 SLC22A16 0.017
318 Alpha-2A adrenergic receptor ADRA2A 0.0169
1757 Myeloperoxidase MPO 0.0168
3639 Thymidine phosphorylase deoA 0.0168
3936 Thymidine phosphorylase TYMP 0.0168
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0164
140 30S ribosomal protein S9 rpsI 0.0163
6719 30S ribosomal protein S9 rpsI 0.0163
6725 30S ribosomal protein S9 rpsI 0.0163
6220 Aryl hydrocarbon receptor AHR 0.0162
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0161
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0159
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0159
3179 2-isopropylmalate synthase leuA 0.0159
165 FL cytokine receptor FLT3 0.0158
193 Beta-1 adrenergic receptor ADRB1 0.0158
1830 5'-nucleotidase NT5E 0.0157
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0157
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0156
53 Solute carrier family 12 member 5 SLC12A5 0.0154
663 Solute carrier family 12 member 4 SLC12A4 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0153
766 Beta-2 adrenergic receptor ADRB2 0.0152
125 DNA polymerase beta POLB 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0149
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0148
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0148
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0148
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0147
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0147
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0147
1760 Aminopeptidase N ANPEP 0.0147
6843 Aminopeptidase N pepN 0.0147
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0147
357 Carbonic anhydrase 2 CA2 0.0145
342 P protein [Includes: DNA-directed DNA polymerase P 0.0145
612 P protein [Includes: DNA-directed DNA polymerase P 0.0145
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0145
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0144
310 Solute carrier family 12 member 2 SLC12A2 0.0143
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0143
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0142
592 Carbonic anhydrase 4 CA4 0.0141
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0141
2599 Tyrosine-protein kinase HCK HCK 0.014
4132 Chloride channel protein ClC-Ka CLCNKA 0.0139
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0139
1405 Thiopurine S-methyltransferase TPMT 0.0139
896 Glutathione S-transferase Mu 1 GSTM1 0.0138
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0137
295 Carbonic anhydrase 1 CA1 0.0136
341 5-hydroxytryptamine 3 receptor HTR3A 0.0134
6033 High affinity interleukin-8 receptor A CXCR1 0.0134
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0134
131 Synaptic vesicular amine transporter SLC18A2 0.0132
6165 Copper-transporting ATPase 1 ATP7A 0.0132
6163 Copper-transporting ATPase 2 ATP7B 0.0132
284 DNA-directed RNA polymerase beta chain rpoB 0.0132
5773 DNA-directed RNA polymerase beta chain rpoB 0.0132
3014 Ribonuclease UK114 HRSP12 0.0132
5428 Replication protein repA 0.0132
3617 Non-heme chloroperoxidase cpo 0.0132
5426 Non-heme chloroperoxidase cpo 0.0132
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0132
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0132
3018 HTH-type transcriptional regulator malT malT 0.0132
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.013
3307 Acriflavine resistance protein B acrB 0.013
1141 Sialidase-1 NEU1 0.0129
64 Neuraminidase NA 0.0129
641 Neuraminidase NA 0.0129
2676 Neuraminidase NA 0.0129
3026 Neuraminidase NA 0.0129
3519 Neuraminidase NA 0.0129
6007 Neuraminidase NA 0.0129
2021 Thrombomodulin THBD 0.0128
3334 Deacetoxycephalosporin C synthetase cefE 0.0127
6146 High affinity copper uptake protein 1 SLC31A1 0.0126
474 Acetylcholinesterase ACHE 0.0126
461 Glycine receptor subunit alpha-3 GLRA3 0.0124
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0124
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0124
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0124
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0123
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0123
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0122
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0122
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0122
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
438 Taste receptor type 1 member 2 TAS1R2 0.0122
5787 Angiopoietin-1 receptor TEK 0.0119
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0119
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0119
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0119
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
2320 Thymidine kinase, cytosolic TK1 0.0118
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0118
725 5-hydroxytryptamine 1D receptor HTR1D 0.0116
885 5-hydroxytryptamine 1B receptor HTR1B 0.0115
1629 Transcription factor AP-1 JUN 0.0115
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0114
2958 Probable tautomerase ydcE pptA 0.0113
49 Endothelin B receptor EDNRB 0.0113
2573 Cocaine esterase cocE 0.0113
7263 Cocaine esterase Not Available 0.0113
469 Annexin A1 ANXA1 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
7 Nitric oxide synthase, inducible NOS2 0.0112
260 Cytochrome P450 51 ERG11 0.0111
761 Cytochrome P450 51 ERG11 0.0111
3163 Cytochrome P450 51 cyp51 0.0111
3115 Ras-related protein Rab-9 RAB9A 0.0111
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0111
3686 Acyl-CoA thioesterase I precursor tesA 0.0111
6014 Cytochrome P450 2A13 CYP2A13 0.011
789 Alpha-1D adrenergic receptor ADRA1D 0.011
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.011
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
6210 Tubulin delta chain TUBD1 0.0109
6212 Tubulin gamma-1 chain TUBG1 0.0109
6211 Tubulin epsilon chain TUBE1 0.0109
992 Protein tyrosine kinase 2 beta PTK2B 0.0109
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0108
2449 Tubulin alpha-3 chain TUBA1A 0.0108
2443 Azurin azu 0.0108
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0108
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0107
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0107
511 5-hydroxytryptamine 1F receptor HTR1F 0.0107
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0107
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0106
578 Endothelin-1 receptor EDNRA 0.0106
115 Penicillin-binding protein 2 mrdA 0.0106
6069 Penicillin-binding protein 2 mrdA 0.0106
6118 Penicillin-binding protein 2 penA 0.0106
6187 Penicillin-binding protein 2 pbpA 0.0106
6686 Penicillin-binding protein 2 pbp2 0.0106
6939 Penicillin-binding protein 2 mrdA 0.0106
7163 Penicillin-binding protein 2 pbpA 0.0106
1192 Sulfotransferase 1A1 SULT1A1 0.0106
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0105
465 Calmodulin CALM1 0.0105
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0105
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0104
4238 50S ribosomal protein L4 rplD 0.0102
5578 50S ribosomal protein L4 rplD 0.0102
6173 50S ribosomal protein L4 rplD 0.0102
6219 50S ribosomal protein L4 rplD 0.0102
5482 Sialidase-2 NEU2 0.0101
183 Vascular endothelial growth factor A VEGFA 0.0101
378 Alpha-2C adrenergic receptor ADRA2C 0.0101
3856 Fibroblast growth factor receptor 3 FGFR3 0.01
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0099
1 Peptidoglycan synthetase ftsI ftsI 0.0099
4155 Peptidoglycan synthetase ftsI ftsI 0.0099
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0099
629 Alpha-2B adrenergic receptor ADRA2B 0.0098
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0097
1198 Serum paraoxonase/arylesterase 1 PON1 0.0097
6223 Penicillin-binding protein 1C pbpC 0.0097
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0097
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0096
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0096
185 Vasopressin V1a receptor AVPR1A 0.0096
751 Potassium channel subfamily K member 6 KCNK6 0.0096
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0096
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0095
603 DNA polymerase alpha catalytic subunit POLA1 0.0094
4237 50S ribosomal protein L22 rplV 0.0094
322 Vasopressin V2 receptor AVPR2 0.0093
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
847 Mu-type opioid receptor OPRM1 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
4226 Uridine phosphorylase 2 UPP2 0.0092
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0091
467 Delta-type opioid receptor OPRD1 0.0091
5353 Glutamate decarboxylase alpha gadA 0.0091
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
4217 Telomerase reverse transcriptase TERT 0.0089
172 Potassium channel subfamily K member 1 KCNK1 0.0088
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0087
696 Kappa-type opioid receptor OPRK1 0.0087
2693 Heat-labile enterotoxin B chain eltB 0.0086
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0085
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0084
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0084
6645 D-amino-acid oxidase DAO 0.0084
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0084
4225 Uridine phosphorylase 1 UPP1 0.0084
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0083
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0083
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0083
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0083
3426 Glutamine synthetase glnA 0.0082
3987 Glutamine synthetase GLUL 0.0082
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
5880 Thrombopoietin receptor MPL 0.0081
76 Nitric-oxide synthase, brain NOS1 0.008
413 Amidophosphoribosyltransferase PPAT 0.0079
2515 Amidophosphoribosyltransferase purF 0.0079
3714 Amidophosphoribosyltransferase purF 0.0079
332 Beta-lactamase blaZ 0.0079
2478 Beta-lactamase ampC 0.0079
2613 Beta-lactamase ampC 0.0079
2635 Beta-lactamase ampC 0.0079
2700 Beta-lactamase penP 0.0079
5445 Beta-lactamase blaB 0.0079
6019 Beta-lactamase SHV-7 0.0079
6701 Beta-lactamase cphA 0.0079
277 Purine nucleoside phosphorylase PNP 0.0077
2870 Purine nucleoside phosphorylase punA 0.0077
2945 Purine nucleoside phosphorylase punA 0.0077
4659 Purine nucleoside phosphorylase TM_1596 0.0077
4825 Purine nucleoside phosphorylase TTHA1435 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
1630 Integrin beta-2 ITGB2 0.0075
2472 Voltage-gated potassium channel kcsA 0.0075
6366 Voltage-gated potassium channel kcsA 0.0075
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0074
6182 Cytochrome P450 2J2 CYP2J2 0.0074
3932 Glutathione S-transferase A2 GSTA2 0.0074
291 Nitric-oxide synthase, endothelial NOS3 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
1648 Elastin ELN 0.0072
3939 Amine oxidase [flavin-containing] B MAOB 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0069
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0068
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0068
2298 Cytochrome P450-cam camC 0.0068
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0068
1867 Major prion protein PRNP 0.0067
713 Sodium-dependent dopamine transporter SLC6A3 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0065
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0065
6138 Multidrug resistance protein 3 ABCB4 0.0065
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0064
1517 Beta-3 adrenergic receptor ADRB3 0.0064
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0062
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0062
130 Prostacyclin synthase PTGIS 0.0061
921 Glutamate receptor 2 GRIA2 0.0061
65 Matrix metalloproteinase-9 Not Available 0.0061
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0061
6044 Serum paraoxonase/lactonase 3 PON3 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0059
84 Nuclear receptor 0B1 NR0B1 0.0059
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
397 Monocarboxylate transporter 3 SLC16A8 0.0059
1039 Histone deacetylase 9 HDAC9 0.0059
6207 30S ribosomal protein S14 rpsN 0.0058
6209 30S ribosomal protein S19 rpsS 0.0058
6712 30S ribosomal protein S19 rpsS 0.0058
6726 30S ribosomal protein S19 rpsS 0.0058
195 Monocarboxylate transporter 7 SLC16A6 0.0058
218 Monocarboxylate transporter 5 SLC16A4 0.0058
429 Monocarboxylate transporter 6 SLC16A5 0.0058
2216 Fibroblast growth factor receptor 4 FGFR4 0.0058
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0058
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0058
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0057
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0057
5126 Arginase rocF 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0056
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0056
572 Integrin alpha-L ITGAL 0.0056
3957 Adenosine deaminase ADA 0.0056
2249 Aspartate aminotransferase aspC 0.0056
2671 Aspartate aminotransferase aspC 0.0056
5490 Aspartate aminotransferase Not Available 0.0056
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0056
6824 Tyrosine-protein kinase Lyn LYN 0.0056
777 Tumor necrosis factor TNF 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0055
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
823 Fibroblast growth factor receptor 2 FGFR2 0.0054
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0054
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0054
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0054
436 5-hydroxytryptamine 2B receptor HTR2B 0.0053
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
638 D(3) dopamine receptor DRD3 0.0053
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0052
52 Pyruvate kinase isozymes R/L PKLR 0.0052
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0052
694 Matrix protein 2 M 0.0051
4122 Histone deacetylase 2 HDAC2 0.0051
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0051
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
976 Platelet glycoprotein IX GP9 0.0051
1010 Cytochrome P450 51A1 CYP51A1 0.0051
232 Corticosteroid-binding globulin SERPINA6 0.005
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0049
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0049
771 Pyruvate carboxylase, mitochondrial PC 0.0049
1714 Mitogen-activated protein kinase 3 MAPK3 0.0049
6111 DNA polymerase epsilon subunit 4 POLE4 0.0049
6112 DNA polymerase epsilon subunit 3 POLE3 0.0048
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0048
6110 DNA polymerase epsilon subunit 2 POLE2 0.0048
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0048
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0048
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0048
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0048
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0048
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0048
1912 Excitatory amino acid transporter 1 SLC1A3 0.0048
4019 Excitatory amino acid transporter 4 SLC1A6 0.0048
4026 Aspartyl aminopeptidase DNPEP 0.0048
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0048
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0048
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0048
922 Glutamate receptor 4 GRIA4 0.0048
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0048
4016 Excitatory amino acid transporter 5 SLC1A7 0.0048
1047 Excitatory amino acid transporter 2 SLC1A2 0.0048
664 Glutamate decarboxylase 2 GAD2 0.0048
3890 Glutamate decarboxylase 2 GAD2 0.0048
4020 Glutamyl aminopeptidase ENPEP 0.0048
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0048
4017 5-oxoprolinase OPLAH 0.0048
4027 Glutamate receptor delta-1 subunit GRID1 0.0048
927 Metabotropic glutamate receptor 8 GRM8 0.0048
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0048
4018 Glutamate receptor delta-2 subunit GRID2 0.0048
925 Metabotropic glutamate receptor 4 GRM4 0.0048
926 Metabotropic glutamate receptor 7 GRM7 0.0048
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0048
6228 Nuclear receptor coactivator 1 NCOA1 0.0047
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0047
6241 Nuclear receptor coactivator 2 NCOA2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0047
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0047
4034 Glutaredoxin-1 GLRX 0.0046
1928 Leukotriene C4 synthase LTC4S 0.0046
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0046
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0046
4037 Hypothetical protein GPX1 0.0046
4297 Hypothetical protein SP_1951 0.0046
4521 Hypothetical protein BC_2969 0.0046
4540 Hypothetical protein TM_1070 0.0046
4555 Hypothetical protein MT1739 0.0046
4569 Hypothetical protein mshD 0.0046
4578 Hypothetical protein PA3270 0.0046
4747 Hypothetical protein PA3967 0.0046
5177 Hypothetical protein TM_0096 0.0046
5194 Hypothetical protein PA1204 0.0046
5240 Hypothetical protein Rv2991 0.0046
5370 Hypothetical protein TM_1158 0.0046
5710 Hypothetical protein Tb927.5.1360 0.0046
4029 Microsomal glutathione S-transferase 3 MGST3 0.0046
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0046
907 Glutathione peroxidase 2 GPX2 0.0046
4032 Microsomal glutathione S-transferase 1 MGST1 0.0046
910 Epididymal secretory glutathione peroxidase GPX5 0.0046
4036 Glutathione peroxidase 6 GPX6 0.0046
903 Glutathione S-transferase A5 GSTA5 0.0046
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0046
4040 Glutathione peroxidase 7 GPX7 0.0046
911 Glutathione peroxidase 3 GPX3 0.0046
906 Glutathione peroxidase 1 GPX1 0.0046
900 Glutathione S-transferase A4 GSTA4 0.0046
4035 Glutathione S-transferase Mu 5 GSTM5 0.0046
4033 S-formylglutathione hydrolase ESD 0.0046
4042 Glutathione transferase omega-2 GSTO2 0.0046
4038 Glutathione peroxidase 4 GPX4 0.0046
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0046
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0046
551 Carnitine O-acetyltransferase CRAT 0.0046
867 Penicillin-binding protein 3 pbpC 0.0046
6119 Penicillin-binding protein 3 pbp3 0.0046
7154 Penicillin-binding protein 3 pbp3 0.0046
7157 Penicillin-binding protein 3 LMHCC_2184 0.0046
7162 Penicillin-binding protein 3 pbpB 0.0046
7172 Penicillin-binding protein 3 pbp3 0.0046
624 Guanidinoacetate N-methyltransferase GAMT 0.0046
768 FK506-binding protein 1A FKBP1A 0.0046
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0046
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0046
1654 Interleukin-1 beta IL1B 0.0045
484 Tyrosine-protein kinase ABL2 ABL2 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0045
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
1618 High affinity nerve growth factor receptor NTRK1 0.0044
267 Plasminogen activator inhibitor 1 SERPINE1 0.0044
2300 Lysozyme E 0.0044
3633 Lysozyme R 0.0044
5597 Lysozyme 17 0.0044
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0044
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0043
5934 Cytochrome P450 26A1 CYP26A1 0.0043
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0043
625 Glutamate carboxypeptidase 2 FOLH1 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
3319 Hydroxyacylglutathione hydrolase HAGH 0.0042
1525 Heparin-binding growth factor 2 FGF2 0.0042
898 Glutathione S-transferase A3 GSTA3 0.0042
897 Glutathione S-transferase kappa 1 GSTK1 0.0042
1291 cAMP response element-binding protein CREB1 0.0041
590 5-hydroxytryptamine 2C receptor HTR2C 0.0041
909 Maleylacetoacetate isomerase GSTZ1 0.0041
6070 Nischarin NISCH 0.0041
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0041
408 Riboflavin kinase RFK 0.0041
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0041
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0041
5 Glutaminase liver isoform, mitochondrial GLS2 0.0041
917 Glutaminase kidney isoform, mitochondrial GLS 0.0041
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0041
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0041
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0041
5261 Phosphoribosylformylglycinamidine synthase purL 0.0041
4210 Toll-like receptor 4 TLR4 0.0041
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0041
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0041
1123 Eosinophil cationic protein RNASE3 0.0041
905 Glutathione transferase omega-1 GSTO1 0.004
899 Glutathione S-transferase Mu 3 GSTM3 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
6221 Steroid hormone receptor ERR1 ESRRA 0.004
4041 Microsomal glutathione S-transferase 2 MGST2 0.004
665 Phosphoserine aminotransferase PSAT1 0.004
4652 Phosphoserine aminotransferase serC 0.004
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0039
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0039
420 Glutamate decarboxylase 1 GAD1 0.0039
3900 Glutamate decarboxylase 1 GAD1 0.0039
5682 Ribonuclease pancreatic RNASE1 0.0039
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0039
916 Metabotropic glutamate receptor 1 GRM1 0.0039
923 Glutamate receptor 3 GRIA3 0.0038
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0038
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0038
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
106 Cannabinoid receptor 2 CNR2 0.0037
2165 Glutathione S-transferase Mu 2 GSTM2 0.0037
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0037
1671 Excitatory amino acid transporter 3 SLC1A1 0.0037
494 Caspase-1 CASP1 0.0037
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0037
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0037
3877 Growth-inhibiting protein 18 GIG18 0.0036
207 Glutathione synthetase GSS 0.0036
5269 Glutathione synthetase gshB 0.0036
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
707 72 kDa type IV collagenase MMP2 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
426 Aspartate aminotransferase, mitochondrial GOT2 0.0036
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
1569 G1/S-specific cyclin-D1 CCND1 0.0036
239 Coagulation factor X F10 0.0035
340 Apoptotic protease-activating factor 1 APAF1 0.0035
6131 Carbonic anhydrase 14 CA14 0.0035
1507 Cytochrome c CYCS 0.0035
936 Ephrin type-A receptor 2 EPHA2 0.0035
763 Tyrosine aminotransferase TAT 0.0035
5493 Tyrosine aminotransferase Not Available 0.0035
901 Glutathione S-transferase Mu 4 GSTM4 0.0035
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
432 D(4) dopamine receptor DRD4 0.0034
760 Fibroblast growth factor 1 FGF1 0.0034
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0034
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0034
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0034
3760 Penicillin-binding protein 5 precursor dacA 0.0033
1864 RET proto-oncogene RET 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0033
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0033
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0032
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0032
6432 Transporter snf 0.0032
705 Glutamate receptor 1 GRIA1 0.0032
828 Phenylalanine-4-hydroxylase PAH 0.0032
3109 Phenylalanine-4-hydroxylase phhA 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
4203 Histamine N-methyltransferase HNMT 0.0031
449 Ornithine decarboxylase ODC1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0031
825 Arsenical pump-driving ATPase ASNA1 0.0031
3435 Arsenical pump-driving ATPase arsA 0.0031
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0031
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0031
154 AFG3-like protein 2 AFG3L2 0.0031
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0031
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0031
733 Activin receptor type 1B ACVR1B 0.0031
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0031
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0031
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0031
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0031
395 ALK tyrosine kinase receptor Not Available 0.0031
4031 Glutathione S-transferase A1 GSTA1 0.0031
2077 Caspase-3 CASP3 0.0031
163 D(1B) dopamine receptor DRD5 0.0031
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0031
714 Glutathione reductase, mitochondrial GSR 0.003
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.003
819 Penicillin-binding protein 4 dacB 0.003
654 Flavin reductase BLVRB 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
164 Histamine H4 receptor HRH4 0.0029
292 Activin receptor type-1 ACVR1 0.0029
849 Activated CDC42 kinase 1 TNK2 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1341 Histamine H3 receptor HRH3 0.0028
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0027
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0027
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0027
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0027
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0027
297 Adenylate cyclase type 1 ADCY1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1025 Aquaporin-1 AQP1 0.0027
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0027
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0026
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0026
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0026
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0026
818 50S ribosomal protein L10 rplJ 0.0026
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0026
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0026
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0025
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
1176 Mitogen-activated protein kinase 1 MAPK1 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
1063 Signal transducer and activator of transcription 5B STAT5B 0.0023
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
740 Argininosuccinate synthase ASS1 0.0023
865 Argininosuccinate synthase ASS1 0.0023
2680 Argininosuccinate synthase argG 0.0023
3194 Argininosuccinate synthase argG 0.0023
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0023
661 ADP/ATP translocase 1 SLC25A4 0.0023
6021 Adenosine kinase ADK 0.0023
3830 Calreticulin CALR 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
2240 Cell division protein kinase 2 CDK2 0.002
822 Aldose reductase AKR1B1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
1058 Cell division protein kinase 5 CDK5 0.002
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0019
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0019
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0019
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0019
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0019
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
3924 Phospholipase D1 PLD1 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
2408 Tyrosine-protein kinase SYK SYK 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
6755 Poliovirus receptor PVR 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
1275 Estrogen sulfotransferase SULT1E1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6859 Protein S100-A4 S100A4 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
6459 Glycodelin PAEP 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5006 RNASE4 protein RNASE4 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
427 Substance-P receptor TACR1 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
997 Protein kinase C beta type PRKCB 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
811 Translocator protein TSPO 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2149 Angiogenin ANG 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
3583 6-phosphogluconolactonase pgl 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
2286 Isocitrate dehydrogenase [NADP] icd 0.0009
2302 Isocitrate dehydrogenase [NADP] icd 0.0009
2771 Isocitrate dehydrogenase [NADP] icd 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
54 Prothrombin F2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
5579 Carboxypeptidase B CPB1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
229 Retinoic acid receptor beta RARB 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6677 Myelin P2 protein PMP2 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2207 Rhodopsin RHO 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
↑