DT-Web

Purine nucleoside phosphorylase


Partner ID 2870
Name Purine nucleoside phosphorylase
Synonyms 820
Gene name punA
General function Nucleotide transport and metabolism
Specific function Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules
Gene sequence + ...

GTGGCTGACCCGCGCCCCGATCCCGACGAACTGGCCCGGCGGGCGGCGCAGGTCATCGCTGACCGCACCGGGATCGGCGAACATGACGTCGCGGTCGTGCTCGGGTCGGGATGGTTACCGGCCGTTGCGGCGTTGGGCTCCCCGACCACCGTGCTGCCGCAGGCCGAACTGCCCGGGTTTGTGCCGCCAACCGCAGCCGGGCATGCGGGCGAGCTACTGTCCGTGCCCATCGGTGCGCACCGGGTGCTGGTGCTGGCCGGTCGCATCCACGCCTACGAGGGACACGACCTGCGCTACGTCGTGCATCCGGTTCGGGCGGCCCGTGCGGCAGGGGCGCAGATTATGGTGCTCACCAACGCCGCCGGTGGGCTGCGGGCGGACCTTCAGGTCGGCCAGCCGGTGCTGATCAGCGATCACCTGAACCTGACCGCACGTTCGCCACTGGTTGGCGGGGAGTTCGTCGACCTGACCGACGCCTACTCACCGCGACTGCGGGAACTCGCCCGCCAATCCGACCCGCAGCTGGCCGAAGGCGTCTACGCCGGCCTGCCGGGGCCGCACTACGAGACACCGGCGGAGATCCGGATGTTGCAGACACTGGGCGCCGACCTGGTCGGCATGTCCACGGTGCACGAGACCATCGCGGCCCGGGCGGCGGGCGCTGAGGTACTGGGCGTATCCCTGGTGACAAATCTGGCGGCCGGGATCACCGGCGAGCCGCTGAGCCACGCCGAGGTGCTCGCCGCCGGAGCCGCATCGGCGACTCGGATGGGCGCGCTGCTAGCCGACGTGATCGCCCGGTTCTAA
Protein sequence + ...

MADPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF
GO Classification
function
purine-nucleoside phosphorylase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
process
physiological process
metabolism
cellular metabolism
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB03411 2-Hydroxymethyl-Pyrrolidine-3,4-Diol
DB03551 4'-Deaza-1'-Aza-2'-Deoxy-1'-(9-Methylene)-Immucillin-H, (3r,4r)-N-[9-Deazahypoxanthin-9-Yl)Methyl]-4-Hydroxymethyl-Pyrrolidin-3-Ol
DB04095 9-Deazahypoxanthine

Associated as Prediction

Id Name
DB00091 Cyclosporine
DB00122 Choline
DB00127 Spermine
DB00140 Riboflavin
DB00152 Thiamine
DB00158 Folic Acid
DB00168 Aspartame
DB00175 Pravastatin
DB00184 Nicotine
DB00197 Troglitazone
DB00206 Reserpine
DB00213 Pantoprazole
DB00220 Nelfinavir
DB00224 Indinavir
DB00229 Cefotiam
DB00242 Cladribine
DB00254 Doxycycline
DB00255 Diethylstilbestrol
DB00264 Metoprolol
DB00280 Disopyramide
DB00285 Venlafaxine
DB00286 Conjugated Estrogens
DB00300 Tenofovir
DB00311 Ethoxzolamide
DB00313 Valproic Acid
DB00316 Acetaminophen
DB00317 Gefitinib
DB00318 Codeine
DB00319 Piperacillin
DB00328 Indomethacin
DB00331 Metformin
DB00338 Omeprazole
DB00345 Aminohippurate
DB00365 Grepafloxacin
DB00368 Norepinephrine
DB00369 Cidofovir
DB00396 Progesterone
DB00398 Sorafenib
DB00406 Gentian Violet
DB00413 Pramipexole
DB00432 Trifluridine
DB00438 Ceftazidime
DB00439 Cerivastatin
DB00441 Gemcitabine
DB00444 Teniposide
DB00446 Chloramphenicol
DB00448 Lansoprazole
DB00456 Cefalotin
DB00457 Prazosin
DB00458 Imipramine
DB00468 Quinine
DB00470 Dronabinol
DB00477 Chlorpromazine
DB00493 Cefotaxime
DB00495 Zidovudine
DB00500 Tolmetin
DB00501 Cimetidine
DB00503 Ritonavir
DB00512 Vancomycin
DB00515 Cisplatin
DB00520 Caspofungin
DB00526 Oxaliplatin
DB00529 Foscarnet
DB00530 Erlotinib
DB00536 Guanidine
DB00541 Vincristine
DB00544 Fluorouracil
DB00549 Zafirlukast
DB00554 Piroxicam
DB00563 Methotrexate
DB00567 Cephalexin
DB00570 Vinblastine
DB00571 Propranolol
DB00575 Clonidine
DB00577 Valaciclovir
DB00578 Carbenicillin
DB00584 Enalapril
DB00586 Diclofenac
DB00594 Amiloride
DB00595 Oxytetracycline
DB00602 Ivermectin
DB00605 Sulindac
DB00606 Cyclothiazide
DB00607 Nafcillin
DB00619 Imatinib
DB00624 Testosterone
DB00631 Clofarabine
DB00640 Adenosine
DB00642 Pemetrexed
DB00649 Stavudine
DB00654 Latanoprost
DB00655 Estrone
DB00661 Verapamil
DB00667 Histamine Phosphate
DB00668 Epinephrine
DB00669 Sumatriptan
DB00672 Chlorpropamide
DB00675 Tamoxifen
DB00678 Losartan
DB00683 Midazolam
DB00688 Mycophenolate mofetil
DB00690 Flurazepam
DB00693 Fluorescein
DB00694 Daunorubicin
DB00695 Furosemide
DB00698 Nitrofurantoin
DB00703 Methazolamide
DB00709 Lamivudine
DB00712 Flurbiprofen
DB00718 Adefovir Dipivoxil
DB00728 Rocuronium
DB00731 Nateglinide
DB00740 Riluzole
DB00741 Hydrocortisone
DB00749 Etodolac
DB00759 Tetracycline
DB00762 Irinotecan
DB00773 Etoposide
DB00779 Nalidixic Acid
DB00783 Estradiol
DB00787 Acyclovir
DB00788 Naproxen
DB00795 Sulfasalazine
DB00798 Gentamicin
DB00811 Ribavirin
DB00812 Phenylbutazone
DB00819 Acetazolamide
DB00821 Carprofen
DB00827 Cinoxacin
DB00861 Diflunisal
DB00863 Ranitidine
DB00879 Emtricitabine
DB00880 Chlorothiazide
DB00887 Bumetanide
DB00900 Didanosine
DB00903 Ethacrynic acid
DB00907 Cocaine
DB00908 Quinidine
DB00914 Phenformin
DB00915 Amantadine
DB00917 Dinoprostone
DB00921 Buprenorphine
DB00925 Phenoxybenzamine
DB00927 Famotidine
DB00936 Salicyclic acid
DB00939 Meclofenamic acid
DB00943 Zalcitabine
DB00945 Acetylsalicylic acid
DB00958 Carboplatin
DB00966 Telmisartan
DB00970 Dactinomycin
DB00973 Ezetimibe
DB00987 Cytarabine
DB00988 Dopamine
DB00997 Doxorubicin
DB00999 Hydrochlorothiazide
DB01004 Ganciclovir
DB01005 Hydroxyurea
DB01009 Ketoprofen
DB01016 Glyburide
DB01017 Minocycline
DB01030 Topotecan
DB01032 Probenecid
DB01033 Mercaptopurine
DB01035 Procainamide
DB01043 Memantine
DB01050 Ibuprofen
DB01051 Novobiocin
DB01053 Penicillin G
DB01059 Norfloxacin
DB01060 Amoxicillin
DB01073 Fludarabine
DB01075 Diphenhydramine
DB01082 Streptomycin
DB01094 Hesperetin
DB01097 Leflunomide
DB01098 Rosuvastatin
DB01103 Quinacrine
DB01114 Chlorpheniramine
DB01124 Tolbutamide
DB01129 Rabeprazole
DB01137 Levofloxacin
DB01140 Cefadroxil
DB01147 Cloxacillin
DB01151 Desipramine
DB01160 Dinoprost Tromethamine
DB01165 Ofloxacin
DB01193 Acebutolol
DB01197 Captopril
DB01199 Tubocurarine
DB01204 Mitoxantrone
DB01212 Ceftriaxone
DB01229 Paclitaxel
DB01232 Saquinavir
DB01234 Dexamethasone
DB01237 Bromodiphenhydramine
DB01248 Docetaxel
DB01254 Dasatinib
DB01262 Decitabine
DB01268 Sunitinib
DB01280 Nelarabine
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB01333 Cefradine
DB01337 Pancuronium
DB01339 Vecuronium
DB01414 Cefacetrile
DB01424 Aminophenazone
DB01435 Antipyrine
DB01580 Oxprenolol
DB01597 Cilastatin
DB01614 Acepromazine
DB01621 Pipotiazine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01629 5-Fluorouridine
DB01645 Genistein
DB01667 8-azaguanine
DB01972 Guanosine-5'-Monophosphate
DB02115 Daidzin
DB02134 Xanthine
DB02222 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine
DB02230 Immucillin-G
DB02256 2'-Deoxyuridine
DB02266 Flufenamic Acid
DB02315 Cyclic Guanosine Monophosphate
DB02377 Guanine
DB02391 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One
DB02527 Cyclic Adenosine Monophosphate
DB02533 Aminoguanidine
DB02568 Peldesine
DB02594 2'-Deoxycytidine
DB02681 Meta Vanadate
DB02745 Uridine
DB02796 9-Deazainosine
DB02857 Guanosine
DB02985 8-Iodo-Guanine
DB03101 Ribose-1-Phosphate
DB03128 Acetylcholine
DB03411 2-Hydroxymethyl-Pyrrolidine-3,4-Diol
DB03431 Adenosine-5'-Diphosphate
DB03467 Naringenin
DB03496 Flavopiridol
DB03551 4'-Deaza-1'-Aza-2'-Deoxy-1'-(9-Methylene)-Immucillin-H, (3r,4r)-N-[9-Deazahypoxanthin-9-Yl)Methyl]-4-Hydroxymethyl-Pyrrolidin-3-Ol
DB03553 Glutaric Acid
DB03566 Spermidine
DB03585 Oxyphenbutazone
DB03609 3-Deoxyguanosine
DB03783 Phenacetin
DB03881 MT-Immucillin-H
DB03942 Carboxylic PRPP
DB04076 Hypoxanthine
DB04095 9-Deazahypoxanthine
DB04133 Degraded Cephaloridine
DB04216 Quercetin
DB04260 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine
DB04348 Taurocholic Acid
DB04485 Deoxythymidine
DB04519 Caprylic acid
DB04540 Cholesterol
DB04574 Estropipate
DB04690 Camptothecin
DB04753 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
DB04754 GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE
DB04757 GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE
DB04830 Buformin
DB04868 Nilotinib
DB05260 Gallium nitrate
DB05294 Vandetanib
DB06151 Acetylcysteine
DB06589 Pazopanib
DB06605 Apixaban
DB06772 Cabazitaxel
DB06872 1-((2-HYDROXYETHOXY)METHYL)-5-(PHENYLTHIO)PYRIMIDINE-2,4(1H,3H)-DIONE
DB06873 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)PYRIMIDINE-2,4(1H,3H)-DIONE
DB07437 1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4(1H,3H)-DIONE
DB07439 1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL)-6-HYDROXYPYRIMIDINE-2,4(1H,3H)-DIONE
DB08245 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-5-NITRO-1H-INDOLE
DB08828 Vismodegib
DB08837 Tetraethylammonium
DB08838 Agmatine
DB08846 Ellagic Acid
DB08860 Pitavastatin
DB08864 Rilpivirine
DB08880 Teriflunomide
DB08881 Vemurafenib
DB08896 Regorafenib
DB08901 Ponatinib
DB08912 Dabrafenib
DB08916 Afatinib
↑