DT-Web

DB00280 - Disopyramide


Identification
Name Disopyramide
Accession Number DB00280 (APRD00507)
Type small molecule
Description A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 339.4745
Groups approved
Monoisotopic Weight 339.231062565
Pharmacology
Indication For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
Mechanism of action Disopyramide is a Type 1A antiarrhythmic drug (ie, similar to procainamide and quinidine). It inhibits the fast sodium channels. In animal studies Disopyramide decreases the rate of diastolic depolarization (phase 4) in cells with augmented automaticity, decreases the upstroke velocity (phase 0) and increases the action potential duration of normal cardiac cells, decreases the disparity in refractoriness between infarcted and adjacent normally perfused myocardium, and has no effect on alpha- or beta-adrenergic receptors.
Absorption Nearly complete
Protein binding 50%-65%
Biotransformation Hepatic
Route of elimination In healthy men, about 50% of a given dose of disopyramide is excreted in the urine as the unchanged drug, about 20% as the mono-N-dealkylated metabolite and 10% as the other metabolites.
Toxicity LD50=580 mg/kg in rats
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acebutolol Acebutolol may decrease symptoms of hypoglycemia and increase the time required for the body to compensate for hypoglycemia.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atenolol The beta-blocker, atenolol, may increase the toxicity of disopyramide.
Azithromycin The macrolide, azithromycin, may increase the effect of disopyramide.
Betaxolol The beta-blocker, betaxolol, may increase the toxicity of disopyramide.
Bevantolol The beta-blocker, bevantolol, may increase the toxicity of disopyramide.
Bisoprolol The beta-blocker, bisoprolol, may increase the toxicity of disopyramide.
Butabarbital arbiturates may increase the metabolism of Disopyramide. Monitor for decreased therapeutic effects of disopyramide if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased.
Carteolol The beta-blocker, carteolol, may increase the toxicity of disopyramide.
Carvedilol The beta-blocker, carvedilol, may increase the toxicity of disopyramide.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clarithromycin Increased risk of cardiotoxicity and arrhythmias
Crizotinib Strong CYP3A4 inhibitors may increase levels of crizotinib. Consider alternative therapy.
Donepezil Possible antagonism of action
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Esmolol The beta-blocker, esmolol, may increase the adverse effects of disopyramide.
Ethotoin The hydantoin decreases the effect of disopyramide
Etravirine Disopyramide, when administered concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to monitor for disopyramide therapy.
Fingolimod Pharmacodynamic synergist. Contraindicated. Increased risk of bradycardia, AV block, and torsade de pointes.
Fosphenytoin The hydantoin decreases the effect of disopyramide
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Insulin Lispro Concomitant therapy with drugs that may increase the blood-glucose-lowering effect of insulin lispro and thus the chance of hypoglycemia should be monitored closely.
Labetalol The beta-blocker, labetolol, may increase the toxicity of disopyramide.
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Mephenytoin The hydantoin decreases the effect of disopyramide
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Metoprolol The beta-blocker, metoprolol, may increase adverse effects of disopyramide.
Moxifloxacin Increased risk of cardiotoxicity and arrhythmias
Nadolol The beta-blocker, nadolol, may increase the toxicity of disopyramide.
Omeprazole The beta-blocker increases toxicity of disopyramide
Oxprenolol The beta-blocker, oxprenolol, may increase the toxicity of disopyramide.
Penbutolol The beta-blocker, penbutolol, may increase the toxicity of disopyramide.
Phenobarbital Phenobarbital decreases levels of disopyramide
Phenytoin The hydantoin decreases the effect of disopyramide
Pindolol The beta-blocker, pindolol, may increase the toxicity of disopyramide.
Practolol The beta-blocker, practolol, may increase the toxicity of disopyramide.
Propranolol The beta-blocker, propranolol, may increase the toxicity of disopyramide.
Quinupristin This combination presents an increased risk of toxicity
Ranolazine Possible additive effect on QT prolongation
Rifampin Rifampin decreases the effect of disopyramide
Rivastigmine Possible antagonism of action
Sotalol The beta-blocker, sotalol, may increase the toxicity of disopyramide.
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telavancin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Telithromycin Telithromycin may reduce clearance of Disopyramide. Concomitant therapy should be avoided.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thiopental Thiopental may increase the metabolism and clearance of Disopyramide. Monitor for changes in therapeutic/adverse effects of Disopyramide if Thiopental is inititaed, discontinued or dose changed.
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Timolol The beta-blocker, timolol, may increase the toxicity of disopyramide.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Additive QTc prolongation may occur. Voriconazole, a strong CYP3A4 inhibitor, may also increase the serum concentration of disopyramide by decreasing its metabolism. Consider alternate therapy or monitor for QTc prolongation and changes in the therapeutic and adverse effects of disopyramide if voriconazole is initiated, discontinued or dose changed.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Sugao M, Fujiki A, Nishida K, Sakabe M, Tsuneda T, Iwamoto J, Mizumaki K, Inoue H: Repolarization dynamics in patients with idiopathic ventricular fibrillation: pharmacological therapy with bepridil and disopyramide. J Cardiovasc Pharmacol. 2005 Jun;45(6):545-9. - Pubmed
  • Fujiki A, Sugao M, Nishida K, Sakabe M, Tsuneda T, Mizumaki K, Inoue H: Repolarization abnormality in idiopathic ventricular fibrillation: assessment using 24-hour QT-RR and QaT-RR relationships. J Cardiovasc Electrophysiol. 2004 Jan;15(1):59-63. - Pubmed
  • Shimizu W, Antzelevitch C, Suyama K, Kurita T, Taguchi A, Aihara N, Takaki H, Sunagawa K, Kamakura S: Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5305
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions antagonist
References
  • Yamamoto N, Ozaki T, Keida Y, Ohtsuka M, Goto T: A comparison of the binding characteristics of class I antiarrhythmic agents for human muscarinic m1-m3 receptors. J Cardiovasc Pharmacol. 1999 Jul;34(1):53-9. - Pubmed
  • Ishida Y, Mizukami M, Taniguchi T, Satake N, Fujiwara M, Shibata S: Anticholinergic action of disopyramide in intestinal smooth muscle of the guinea pig: inhibition of muscarinic receptors (M1 and M2). Jpn J Pharmacol. 1990 Feb;52(2):363-70. - Pubmed
DTHybrid score 0.7426
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action unknown
Actions antagonist
References
  • Yamamoto N, Ozaki T, Keida Y, Ohtsuka M, Goto T: A comparison of the binding characteristics of class I antiarrhythmic agents for human muscarinic m1-m3 receptors. J Cardiovasc Pharmacol. 1999 Jul;34(1):53-9. - Pubmed
  • Ishida Y, Mizukami M, Taniguchi T, Satake N, Fujiwara M, Shibata S: Anticholinergic action of disopyramide in intestinal smooth muscle of the guinea pig: inhibition of muscarinic receptors (M1 and M2). Jpn J Pharmacol. 1990 Feb;52(2):363-70. - Pubmed
DTHybrid score 0.634
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action unknown
Actions antagonist
References
  • Yamamoto N, Ozaki T, Keida Y, Ohtsuka M, Goto T: A comparison of the binding characteristics of class I antiarrhythmic agents for human muscarinic m1-m3 receptors. J Cardiovasc Pharmacol. 1999 Jul;34(1):53-9. - Pubmed
DTHybrid score 0.6141
Potassium voltage-gated channel subfamily D member 2
Name Potassium voltage-gated channel subfamily D member 2
Gene Name KCND2
Pharmacological action unknown
Actions inhibitor
References
  • Casis O, Sanchez-Chapula JA: Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel. J Cardiovasc Pharmacol. 1998 Oct;32(4):521-6. - Pubmed
DTHybrid score 0.3523
Potassium voltage-gated channel subfamily D member 3
Name Potassium voltage-gated channel subfamily D member 3
Gene Name KCND3
Pharmacological action unknown
Actions inhibitor
References
  • Casis O, Sanchez-Chapula JA: Disopyramide, imipramine, and amitriptyline bind to a common site on the transient outward K+ channel. J Cardiovasc Pharmacol. 1998 Oct;32(4):521-6. - Pubmed
DTHybrid score 0.3523

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Echizen H, Tanizaki M, Tatsuno J, Chiba K, Berwick T, Tani M, Gonzalez FJ, Ishizaki T: Identification of CYP3A4 as the enzyme involved in the mono-N-dealkylation of disopyramide enantiomers in humans. Drug Metab Dispos. 2000 Aug;28(8):937-44. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Zhang L, Fitzloff JF, Engel LC, Cook CS: Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide. Xenobiotica. 2001 Feb;31(2):73-83. - Pubmed
DTHybrid score 0.4673

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed
  • Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score 0.3358
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score 0.2869

Carriers


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions
References Not Available
DTHybrid score 0.3358
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions
References Not Available
DTHybrid score 0.2869

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.3065
450 Muscarinic acetylcholine receptor M4 CHRM4 0.2894
274 Muscarinic acetylcholine receptor M5 CHRM5 0.2347
1588 Multidrug resistance protein 1 ABCB1 0.2062
6016 Cytochrome P450 2C19 CYP2C19 0.1687
4200 Cytochrome P450 1A2 CYP1A2 0.1664
6013 Cytochrome P450 2E1 CYP2E1 0.1619
4757 Cytochrome P450 2C9 CYP2C9 0.1519
492 Histamine H1 receptor HRH1 0.1421
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.1378
4118 Cytochrome P450 3A5 CYP3A5 0.1333
587 Serum albumin ALB 0.1225
4924 Cytochrome P450 2C8 CYP2C8 0.1138
556 Alpha-1A adrenergic receptor ADRA1A 0.1096
6030 Cytochrome P450 2B6 CYP2B6 0.1075
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.1051
502 5-hydroxytryptamine 2A receptor HTR2A 0.1045
3923 Cholinesterase BCHE 0.1026
6107 Cytochrome P450 3A7 CYP3A7 0.0957
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0913
833 Organic cation/carnitine transporter 1 SLC22A4 0.0912
6147 Solute carrier family 22 member 3 SLC22A3 0.0895
118 Organic cation/carnitine transporter 2 SLC22A5 0.0841
824 Sodium-dependent serotonin transporter SLC6A4 0.0822
789 Alpha-1D adrenergic receptor ADRA1D 0.0813
831 D(2) dopamine receptor DRD2 0.0716
320 5-hydroxytryptamine 1A receptor HTR1A 0.0623
6024 Cytochrome P450 1A1 CYP1A1 0.0601
23 D(1A) dopamine receptor DRD1 0.0564
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0548
632 Alpha-1B adrenergic receptor ADRA1B 0.0535
318 Alpha-2A adrenergic receptor ADRA2A 0.053
590 5-hydroxytryptamine 2C receptor HTR2C 0.0501
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0497
6106 Cytochrome P450 2C18 CYP2C18 0.0437
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0436
465 Calmodulin CALM1 0.0416
766 Beta-2 adrenergic receptor ADRB2 0.0398
5718 Cytochrome P450 2A6 CYP2A6 0.0386
6142 Solute carrier family 22 member 8 SLC22A8 0.0381
341 5-hydroxytryptamine 3 receptor HTR3A 0.0372
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0366
378 Alpha-2C adrenergic receptor ADRA2C 0.0364
6432 Transporter snf 0.0355
193 Beta-1 adrenergic receptor ADRB1 0.0353
862 Multidrug resistance-associated protein 1 ABCC1 0.0352
629 Alpha-2B adrenergic receptor ADRA2B 0.0342
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0322
713 Sodium-dependent dopamine transporter SLC6A3 0.0316
124 Histamine H2 receptor HRH2 0.0315
1729 Solute carrier family 22 member 6 SLC22A6 0.0303
432 D(4) dopamine receptor DRD4 0.03
1618 High affinity nerve growth factor receptor NTRK1 0.0292
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.029
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0275
638 D(3) dopamine receptor DRD3 0.0269
696 Kappa-type opioid receptor OPRK1 0.0256
776 Bile salt export pump ABCB11 0.025
467 Delta-type opioid receptor OPRD1 0.0248
474 Acetylcholinesterase ACHE 0.0248
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0239
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0232
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0229
436 5-hydroxytryptamine 2B receptor HTR2B 0.0224
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0221
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.022
20 Prostaglandin G/H synthase 1 PTGS1 0.0209
885 5-hydroxytryptamine 1B receptor HTR1B 0.0208
163 D(1B) dopamine receptor DRD5 0.0201
172 Potassium channel subfamily K member 1 KCNK1 0.0196
723 Cytosolic phospholipase A2 PLA2G4A 0.0188
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0184
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0182
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.018
6143 Solute carrier family 22 member 7 SLC22A7 0.0178
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0176
725 5-hydroxytryptamine 1D receptor HTR1D 0.0173
1898 Cytochrome P450 1B1 CYP1B1 0.0168
2164 Multidrug resistance-associated protein 4 ABCC4 0.0166
871 Glucocorticoid receptor NR3C1 0.0163
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0163
844 Epidermal growth factor receptor EGFR 0.0161
6010 Thiamine transporter 1 SLC19A2 0.0159
3939 Amine oxidase [flavin-containing] B MAOB 0.0159
847 Mu-type opioid receptor OPRM1 0.0158
3811 Cytochrome P450 19A1 CYP19A1 0.0153
528 5-hydroxytryptamine 1E receptor HTR1E 0.0153
731 HIV-1 protease HIV-1 protease 0.0153
136 Estrogen receptor ESR1 0.0152
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.015
716 5-hydroxytryptamine 7 receptor HTR7 0.015
1256 5-hydroxytryptamine 6 receptor HTR6 0.0149
2129 Sucrase-isomaltase, intestinal SI 0.0149
1024 Solute carrier family 22 member 11 SLC22A11 0.0145
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0143
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0143
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
1656 CYP2B protein CYP2B 0.0142
3941 Amine oxidase [flavin-containing] A MAOA 0.0139
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0136
1517 Beta-3 adrenergic receptor ADRB3 0.0134
4773 Deoxycytidine kinase DCK 0.0133
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0133
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0133
6148 Multidrug resistance-associated protein 7 ABCC10 0.0132
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.013
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0128
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0118
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0118
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0118
380 Cytochrome P450 17A1 CYP17A1 0.0118
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
7 Nitric oxide synthase, inducible NOS2 0.0114
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.011
33 Cystine/glutamate transporter SLC7A11 0.011
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.011
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0109
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0106
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0105
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0105
6220 Aryl hydrocarbon receptor AHR 0.0104
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0103
3876 Aromatic-L-amino-acid decarboxylase DDC 0.01
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0099
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0099
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
290 Prostaglandin G/H synthase 2 PTGS2 0.0096
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0096
1757 Myeloperoxidase MPO 0.0094
4203 Histamine N-methyltransferase HNMT 0.0094
1360 Sphingomyelin phosphodiesterase SMPD1 0.0094
6141 Sodium/bile acid cotransporter SLC10A1 0.0092
164 Histamine H4 receptor HRH4 0.0091
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0091
6070 Nischarin NISCH 0.0089
6137 Multidrug resistance-associated protein 6 ABCC6 0.0087
694 Matrix protein 2 M 0.0086
338 DNA polymerase UL30 0.0086
379 DNA polymerase UL54 0.0086
697 DNA polymerase ORF28 0.0086
2482 DNA polymerase 43 0.0086
4104 DNA polymerase BALF5 0.0086
1830 5'-nucleotidase NT5E 0.0084
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0084
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0083
614 Progesterone receptor PGR 0.0082
756 Sex hormone-binding globulin SHBG 0.0082
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0082
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0081
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
921 Glutamate receptor 2 GRIA2 0.0081
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0081
125 DNA polymerase beta POLB 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.008
751 Potassium channel subfamily K member 6 KCNK6 0.008
131 Synaptic vesicular amine transporter SLC18A2 0.008
738 Monocarboxylate transporter 1 SLC16A1 0.0078
817 DNA topoisomerase 2-alpha TOP2A 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0077
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0076
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0075
477 DNA topoisomerase 4 subunit A parC 0.0075
886 DNA topoisomerase 4 subunit A parC 0.0075
6226 DNA topoisomerase 4 subunit A parC 0.0075
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0075
6136 Multidrug resistance-associated protein 5 ABCC5 0.0074
3947 Xanthine dehydrogenase/oxidase XDH 0.0074
404 DNA gyrase subunit A gyrA 0.0074
6224 DNA gyrase subunit A gyrA 0.0074
828 Phenylalanine-4-hydroxylase PAH 0.0072
3109 Phenylalanine-4-hydroxylase phhA 0.0072
3611 Cytidine deaminase cdd 0.0071
3707 Cytidine deaminase cdd 0.0071
4211 Cytidine deaminase CDA 0.0071
6171 Solute carrier family 28 member 3 SLC28A3 0.007
260 Cytochrome P450 51 ERG11 0.0069
761 Cytochrome P450 51 ERG11 0.0069
3163 Cytochrome P450 51 cyp51 0.0069
1050 Bile salt sulfotransferase SULT2A1 0.0069
768 FK506-binding protein 1A FKBP1A 0.0068
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0067
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0067
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0066
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0066
1341 Histamine H3 receptor HRH3 0.0065
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0064
5126 Arginase rocF 0.0064
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0064
1770 Phospholipase C PLCL1 0.0064
2841 Phospholipase C plc 0.0064
6182 Cytochrome P450 2J2 CYP2J2 0.0064
869 Estrogen receptor beta ESR2 0.0061
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0061
504 Mast/stem cell growth factor receptor KIT 0.0061
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.006
1864 RET proto-oncogene RET 0.006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0059
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0059
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0059
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0059
5787 Angiopoietin-1 receptor TEK 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
228 Beta platelet-derived growth factor receptor PDGFRB 0.0058
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
740 Argininosuccinate synthase ASS1 0.0058
865 Argininosuccinate synthase ASS1 0.0058
2680 Argininosuccinate synthase argG 0.0058
3194 Argininosuccinate synthase argG 0.0058
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0057
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0056
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0056
161 Tubulin beta chain TUBB 0.0055
312 Tubulin beta chain TUB2 0.0055
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0055
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0054
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0053
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0053
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0053
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0053
6014 Cytochrome P450 2A13 CYP2A13 0.0053
183 Vascular endothelial growth factor A VEGFA 0.0052
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0052
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0051
6031 Cytochrome P450 3A43 CYP3A43 0.0051
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0051
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0051
624 Guanidinoacetate N-methyltransferase GAMT 0.005
6146 High affinity copper uptake protein 1 SLC31A1 0.005
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.005
976 Platelet glycoprotein IX GP9 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.005
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0049
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0049
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0049
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0049
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0049
6165 Copper-transporting ATPase 1 ATP7A 0.0049
6163 Copper-transporting ATPase 2 ATP7B 0.0049
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0049
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0048
908 Glutathione S-transferase theta-1 GSTT1 0.0047
904 Glutathione S-transferase P GSTP1 0.0047
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0047
6020 Aldehyde oxidase AOX1 0.0047
896 Glutathione S-transferase Mu 1 GSTM1 0.0046
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0046
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0046
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0045
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0045
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0045
737 Mineralocorticoid receptor NR3C2 0.0045
592 Carbonic anhydrase 4 CA4 0.0045
94 5-hydroxytryptamine 4 receptor HTR4 0.0045
468 Cytochrome P450 4A11 CYP4A11 0.0045
342 P protein [Includes: DNA-directed DNA polymerase P 0.0044
612 P protein [Includes: DNA-directed DNA polymerase P 0.0044
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0044
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
2449 Tubulin alpha-3 chain TUBA1A 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0043
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0043
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0042
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0042
6167 Organic solute transporter subunit beta OSTB 0.0042
6166 Organic solute transporter subunit alpha OSTA 0.0042
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
153 Dopamine beta-hydroxylase DBH 0.004
29 Tubulin beta-1 chain TUBB1 0.004
952 Dipeptidyl peptidase 4 DPP4 0.004
1629 Transcription factor AP-1 JUN 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
295 Carbonic anhydrase 1 CA1 0.0039
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0039
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0038
146 Androgen receptor AR 0.0038
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
5626 Nucleoside diphosphate kinase B NME2 0.0038
702 UMP-CMP kinase CMPK1 0.0037
527 Prostacyclin receptor PTGIR 0.0036
2300 Lysozyme E 0.0036
3633 Lysozyme R 0.0036
5597 Lysozyme 17 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0036
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0036
3926 Choline transporter-like protein 2 SLC44A2 0.0036
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0036
1686 Choline transporter-like protein 1 SLC44A1 0.0036
3927 Choline transporter-like protein 3 SLC44A3 0.0036
861 Choline kinase alpha CHKA 0.0036
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0036
3925 Choline transporter-like protein 4 SLC44A4 0.0036
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0036
769 High-affinity choline transporter 1 SLC5A7 0.0036
700 Choline dehydrogenase, mitochondrial CHDH 0.0036
576 Choline O-acetyltransferase CHAT 0.0036
3922 Phospholipase D2 PLD2 0.0036
3924 Phospholipase D1 PLD1 0.0036
6211 Tubulin epsilon chain TUBE1 0.0036
6212 Tubulin gamma-1 chain TUBG1 0.0036
6210 Tubulin delta chain TUBD1 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0035
856 Vitamin D3 receptor VDR 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0035
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0035
939 50S ribosomal protein L3 rplC 0.0035
811 Translocator protein TSPO 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0034
4120 NADPH--cytochrome P450 reductase POR 0.0034
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
357 Carbonic anhydrase 2 CA2 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0033
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0033
6218 Pannexin-1 PANX1 0.0033
814 Ryanodine receptor 1 RYR1 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0031
449 Ornithine decarboxylase ODC1 0.0031
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0031
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0031
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0031
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0031
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0031
5294 Nucleoside diphosphate kinase A NME1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.003
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.003
3810 Catechol O-methyltransferase COMT 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
6149 Solute carrier family 22 member 10 SLC22A10 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0029
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
6131 Carbonic anhydrase 14 CA14 0.0028
4217 Telomerase reverse transcriptase TERT 0.0028
6126 Carbonic anhydrase 7 CA7 0.0028
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0028
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
6122 Carbonic anhydrase 3 CA3 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
6135 Sodium channel subunit beta-4 SCN4B 0.0026
6134 Sodium channel subunit beta-3 SCN3B 0.0026
6132 Sodium channel subunit beta-1 SCN1B 0.0026
6127 Carbonic anhydrase-related protein CA8 0.0026
6133 Sodium channel subunit beta-2 SCN2B 0.0026
6128 Carbonic anhydrase-related protein 10 CA10 0.0026
6129 Carbonic anhydrase-related protein 11 CA11 0.0026
49 Endothelin B receptor EDNRB 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0025
6085 Fatty acid-binding protein, intestinal FABP2 0.0025
4604 Liver carboxylesterase 1 CES1 0.0025
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
4192 DNA topoisomerase 2-beta TOP2B 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0023
777 Tumor necrosis factor TNF 0.0023
70 Type-1 angiotensin II receptor AGTR1 0.0023
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0023
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
6130 Carbonic anhydrase 13 CA13 0.0022
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
489 Monocarboxylate transporter 2 SLC16A7 0.0021
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
373 Transthyretin TTR 0.0019
3932 Glutathione S-transferase A2 GSTA2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0019
3007 Carbonic anhydrase 12 CA12 0.0018
4205 Carbonic anhydrase 9 CA9 0.0018
6102 Arylamine N-acetyltransferase 2 NAT2 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
26 Vascular endothelial growth factor receptor 3 FLT4 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
683 Potassium transporter GK0582 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
32 Vascular endothelial growth factor receptor 1 FLT1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0016
3233 Bile acid receptor NR1H4 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
427 Substance-P receptor TACR1 0.0015
275 Arachidonate 5-lipoxygenase ALOX5 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
1541 Metalloproteinase mmp20 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0014
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
4122 Histone deacetylase 2 HDAC2 0.0013
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
16 Adenosine A1 receptor ADORA1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
3587 Gastrotropin FABP6 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
1178 Adenosine A2a receptor ADORA2A 0.0011
239 Coagulation factor X F10 0.0011
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
365 Dihydrofolate reductase DHFR 0.0011
2381 Dihydrofolate reductase DFR1 0.0011
2833 Dihydrofolate reductase Not Available 0.0011
2931 Dihydrofolate reductase folA 0.0011
3544 Dihydrofolate reductase folA 0.0011
3682 Dihydrofolate reductase folA 0.0011
6642 Dihydrofolate reductase folA 0.0011
6756 Dihydrofolate reductase dfrA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
54 Prothrombin F2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
165 FL cytokine receptor FLT3 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
469 Annexin A1 ANXA1 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
4311 tRNA TRDMT1 0.0007
4325 tRNA trmD 0.0007
4328 tRNA trmD 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3937 Fatty-acid amide hydrolase FAAH 0.0006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
3809 Estrogen-related receptor gamma ESRRG 0.0006
273 Apoptosis regulator Bcl-2 BCL2 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
563 Thyroid peroxidase TPO 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
634 Squalene monooxygenase SQLE 0.0006
7196 Squalene monooxygenase ERG1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
84 Nuclear receptor 0B1 NR0B1 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
1192 Sulfotransferase 1A1 SULT1A1 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
823 Fibroblast growth factor receptor 2 FGFR2 0.0005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1992 Vitamin D-binding protein GC 0.0004
319 Opioid receptor, sigma 1 OPRS1 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1630 Integrin beta-2 ITGB2 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
174 Sigma 1-type opioid receptor SIGMAR1 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
6044 Serum paraoxonase/lactonase 3 PON3 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
572 Integrin alpha-L ITGAL 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0003
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
1275 Estrogen sulfotransferase SULT1E1 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
5934 Cytochrome P450 26A1 CYP26A1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0002
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
3957 Adenosine deaminase ADA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
2207 Rhodopsin RHO 0.0002
76 Nitric-oxide synthase, brain NOS1 0.0002
2981 Phospholipase A2, membrane associated PLA2G2A 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
↑