DT-Web

DB00679 - Thioridazine


Identification
Name Thioridazine
Accession Number DB00679 (APRD00596)
Type small molecule
Description A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 370.575
Groups approved
Monoisotopic Weight 370.153740222
Pharmacology
Indication For the treatment of schizophrenia and generalized anxiety disorder.
Mechanism of action Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Absorption 60%
Protein binding 95%
Biotransformation Hepatic
Route of elimination Not Available
Toxicity LD50=956-1034 mg/kg (Orally in rats); Agitation, blurred vision, coma, confusion, constipation, difficulty breathing, dilated or constricted pupils, diminished flow of urine, dry mouth, dry skin, excessively high or low body temperature, extremely low blood pressure, fluid in the lungs, heart abnormalities, inability to urinate, intestinal blockage, nasal congestion, restlessness, sedation, seizures, shock
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Abiraterone Abiraterone increases levels by affecting CYP2D6 metabolism. Interaction is significant so monitor closely.
Amiodarone Increased risk of cardiotoxicity and arrhythmias
Amitriptyline Increased risk of cardiotoxicity and arrhythmias
Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Artemether Additive QTc-prolongation may occur. Concomitant therapy is contraindicated.
Asenapine Thioridazine is a CYP2D6 substrate in which concomitant therapy with asenapine will increase serum levels of thioridazine. Consider alternative therapy.
Astemizole Increased risk of cardiotoxicity and arrhythmias
Atomoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Benzphetamine Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
Bretylium Increased risk of cardiotoxicity and arrhythmias
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Bupropion Bupropion may increase the effect and toxicity of thioridazine.
Chloroquine Increased risk of cardiotoxicity and arrhythmias
Chlorpromazine Increased risk of cardiotoxicity and arrhythmias
Cisapride Increased risk of cardiotoxicity and arrhythmias
Crizotinib Concurrent use with drugs that prolong QTc interval is contraindicated.
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Diltiazem Increased risk of cardiotoxicity and arrhythmias
Diphenhydramine Increased risk of cardiotoxicity and arrhythmias
Disopyramide Increased risk of cardiotoxicity and arrhythmias
Dofetilide Increased risk of cardiotoxicity and arrhythmias
Donepezil Possible antagonism of action
Doxepin Increased risk of cardiotoxicity and arrhythmias
Duloxetine Increased risk of cardiotoxicity and arrhythmias
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Flecainide Increased risk of cardiotoxicity and arrhythmias
Fluoxetine Increased risk of cardiotoxicity and arrhythmias
Fluvoxamine Increased risk of cardiotoxicity and arrhythmias
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine Thioridazine may decrease the effect of guanethidine.
Halofantrine Increased risk of cardiotoxicity and arrhythmias
Haloperidol Increased risk of cardiotoxicity and arrhythmias
Imipramine Increased risk of cardiotoxicity and arrhythmias
Josamycin Increased risk of cardiotoxicity and arrhythmias
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Lorcaserin Avoid combination.The combination is likely to reduce the metabolism of Thioridazine.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Maprotiline Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
Metrizamide Increased risk of convulsions
Mirabegron Mirabegron is a moderate CYP2D6 inhibitor and may cause an increase in exposure of CYP2D6 substrates. Monitor concomitant therapy closely.
Paroxetine Increased risk of cardiotoxicity and arrhythmias
Penicillin G Increased risk of cardiotoxicity and arrhythmias
Pentamidine Increased risk of cardiotoxicity and arrhythmias
Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Pimozide Increased risk of cardiotoxicity and arrhythmias
Pindolol Increased risk of cardiotoxicity and arrhythmias
Procainamide Increased risk of cardiotoxicity and arrhythmias
Propafenone Increased risk of cardiotoxicity and arrhythmias.
Propranolol Increased risk of cardiotoxicity and arrhythmias
Quinidine Increased risk of cardiotoxicity and arrhythmias
Quinidine barbiturate Increased risk of cardiotoxicity and arrhythmias
Quinine Increased risk of cardiotoxicity and arrhythmias
Ranolazine Possible additive effect on QT prolongation
Rivastigmine Possible antagonism of action
Sertindole Increased risk of cardiotoxicity and arrhythmias
Sotalol Increased risk of cardiotoxicity and arrhythmias
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Spiramycin Increased risk of cardiotoxicity and arrhythmias
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Thioridazine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Tacrolimus May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Tamoxifen Thioridazine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Thioridazine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Thioridazine is initiated, discontinued, or dose changed.
Telithromycin Telithromycin may increase the QTc-prolonging effect of Thioridazine. Concomitant therapy should be avoided.
Terbinafine Terbinafine may increase serum concentrations of Thioridazine. Concomitant therapy is contraindicated.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects.
Thiothixene May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Ticlopidine Ticlopidine may decrease the metabolism of thioridazine. Concomitant therapy is contraindicated.
Toremifene May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Tramadol Thioridazine may decrease the effect of Tramadol by decreasing active metabolite production.
Tranylcypromine Tranylcypromine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Thioridazine. Concomitant therapy is contraindicated.
Trimethobenzamide Trimethobenzamide and Thioridazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Triprolidine The antihistamine, Triprolidine, may increase the arrhythmogenic effect of the phenothiazine, Thioridazine. Monitor for symptoms of ventricular arrhythmias. Additive anticholinergic and CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Thioridazine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Vilazodone Thioridazine prescribing information contraindicates the concomitant use of agents that inhibit CYP2D6 isoenzymes. Avoid combination.
Voriconazole Additive QTc prolongation may occur. Concomitant use is contraindicated.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc-prolonging effects increases risk of cardiac arrhythmias. Concomitant therapy is contraindicated.
Food Interactions Not Available

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Seeman P: Atypical neuroleptics: role of multiple receptors, endogenous dopamine, and receptor linkage. Acta Psychiatr Scand Suppl. 1990;358:14-20. - Pubmed
  • Assie MB, Sleight AJ, Koek W: Biphasic displacement of [3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics. Eur J Pharmacol. 1993 Jun 24;237(2-3):183-9. - Pubmed
  • Dimpfel W, Spuler M, Wessel K: Different neuroleptics show common dose and time dependent effects in quantitative field potential analysis in freely moving rats. Psychopharmacology (Berl). 1992;107(2-3):195-202. - Pubmed
  • Barth VN, Chernet E, Martin LJ, Need AB, Rash KS, Morin M, Phebus LA: Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer. Life Sci. 2006 May 22;78(26):3007-12. Epub 2006 Jan 24. - Pubmed
  • Carey GJ, Bergman J: Discriminative-stimulus effects of clozapine in squirrel monkeys: comparison with conventional and novel antipsychotic drugs. Psychopharmacology (Berl). 1997 Aug;132(3):261-9. - Pubmed
DTHybrid score 0.5149
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions antagonist
References
  • Hammock RG, Schroeder SR, Levine WR: The effect of clozapine on self-injurious behavior. J Autism Dev Disord. 1995 Dec;25(6):611-26. - Pubmed
DTHybrid score 0.4035
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions antagonist
References
  • Sleight AJ, Koek W, Bigg DC: Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors. Eur J Pharmacol. 1993 Jul 20;238(2-3):407-10. - Pubmed
  • Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. - Pubmed
DTHybrid score 0.5553
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action yes
Actions antagonist
References
  • Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. - Pubmed
DTHybrid score 0.3952
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Andree TH, Mikuni M, Tong CY, Koenig JI, Meltzer HY: Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex. J Neurochem. 1986 Jan;46(1):191-7. - Pubmed
  • Canton H, Verriele L, Millan MJ: Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptor-mediated phosphoinositide (PI) turnover by clozapine in the rat: a comparison to other antipsychotics. Neurosci Lett. 1994 Nov 7;181(1-2):65-8. - Pubmed
  • Burki HR: Binding of psychoactive drugs to rat brain amine receptors, measured ex vivo, and their effects on the metabolism of biogenic amines. Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):258-66. - Pubmed
  • Costall B, Naylor RJ: Behavioural interactions between 5-hydroxytryptophan, neuroleptic agents and 5-HT receptor antagonists in modifying rodent responding to aversive situations. Br J Pharmacol. 1995 Dec;116(7):2989-99. - Pubmed
  • Morisset S, Sahm UG, Traiffort E, Tardivel-Lacombe J, Arrang JM, Schwartz JC: Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade. J Pharmacol Exp Ther. 1999 Feb;288(2):590-6. - Pubmed
DTHybrid score 0.4183
Potassium voltage-gated channel subfamily H member 2
Name Potassium voltage-gated channel subfamily H member 2
Gene Name KCNH2
Pharmacological action unknown
Actions inhibitor
References
  • Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC: hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656. Biochem Biophys Res Commun. 2006 Dec 8;351(1):273-80. Epub 2006 Oct 23. - Pubmed
DTHybrid score 0.2356

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Otani K, Aoshima T: Pharmacogenetics of classical and new antipsychotic drugs. Ther Drug Monit. 2000 Feb;22(1):118-21. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6845
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4764
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5413
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3728
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5498
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3408

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.583
1588 Multidrug resistance protein 1 ABCB1 0.3193
318 Alpha-2A adrenergic receptor ADRA2A 0.2466
4118 Cytochrome P450 3A5 CYP3A5 0.2211
6030 Cytochrome P450 2B6 CYP2B6 0.2052
789 Alpha-1D adrenergic receptor ADRA1D 0.1924
320 5-hydroxytryptamine 1A receptor HTR1A 0.1866
590 5-hydroxytryptamine 2C receptor HTR2C 0.1863
492 Histamine H1 receptor HRH1 0.1715
6107 Cytochrome P450 3A7 CYP3A7 0.1698
638 D(3) dopamine receptor DRD3 0.1538
6024 Cytochrome P450 1A1 CYP1A1 0.1462
432 D(4) dopamine receptor DRD4 0.1444
629 Alpha-2B adrenergic receptor ADRA2B 0.1378
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1301
587 Serum albumin ALB 0.1292
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1289
378 Alpha-2C adrenergic receptor ADRA2C 0.1262
5718 Cytochrome P450 2A6 CYP2A6 0.1245
163 D(1B) dopamine receptor DRD5 0.1171
824 Sodium-dependent serotonin transporter SLC6A4 0.1129
20 Prostaglandin G/H synthase 1 PTGS1 0.1052
6145 Solute carrier family 22 member 1 SLC22A1 0.1041
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0932
193 Beta-1 adrenergic receptor ADRB1 0.0929
725 5-hydroxytryptamine 1D receptor HTR1D 0.0918
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0886
766 Beta-2 adrenergic receptor ADRB2 0.088
436 5-hydroxytryptamine 2B receptor HTR2B 0.0877
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0866
885 5-hydroxytryptamine 1B receptor HTR1B 0.086
713 Sodium-dependent dopamine transporter SLC6A3 0.086
274 Muscarinic acetylcholine receptor M5 CHRM5 0.085
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0827
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0776
716 5-hydroxytryptamine 7 receptor HTR7 0.0774
6106 Cytochrome P450 2C18 CYP2C18 0.0692
1256 5-hydroxytryptamine 6 receptor HTR6 0.0666
3941 Amine oxidase [flavin-containing] A MAOA 0.0665
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0606
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0604
6144 Solute carrier family 22 member 2 SLC22A2 0.0574
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0556
341 5-hydroxytryptamine 3 receptor HTR3A 0.0543
465 Calmodulin CALM1 0.0542
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0531
290 Prostaglandin G/H synthase 2 PTGS2 0.0531
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0512
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.048
131 Synaptic vesicular amine transporter SLC18A2 0.0477
1729 Solute carrier family 22 member 6 SLC22A6 0.0441
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0429
1898 Cytochrome P450 1B1 CYP1B1 0.0424
3811 Cytochrome P450 19A1 CYP19A1 0.0419
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.039
118 Organic cation/carnitine transporter 2 SLC22A5 0.0389
862 Multidrug resistance-associated protein 1 ABCC1 0.0385
94 5-hydroxytryptamine 4 receptor HTR4 0.0379
3923 Cholinesterase BCHE 0.0359
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0356
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0354
3939 Amine oxidase [flavin-containing] B MAOB 0.0352
776 Bile salt export pump ABCB11 0.0352
6147 Solute carrier family 22 member 3 SLC22A3 0.0348
817 DNA topoisomerase 2-alpha TOP2A 0.0341
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0341
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0325
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0302
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0301
233 Potassium channel subfamily K member 2 KCNK2 0.0301
528 5-hydroxytryptamine 1E receptor HTR1E 0.0298
260 Cytochrome P450 51 ERG11 0.0294
761 Cytochrome P450 51 ERG11 0.0294
3163 Cytochrome P450 51 cyp51 0.0294
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0291
3876 Aromatic-L-amino-acid decarboxylase DDC 0.029
6182 Cytochrome P450 2J2 CYP2J2 0.0287
2164 Multidrug resistance-associated protein 4 ABCC4 0.0272
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0268
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0259
36 Insulin receptor INSR 0.0258
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0258
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0256
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0252
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0249
174 Sigma 1-type opioid receptor SIGMAR1 0.0248
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0245
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0241
6142 Solute carrier family 22 member 8 SLC22A8 0.0241
833 Organic cation/carnitine transporter 1 SLC22A4 0.024
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.024
136 Estrogen receptor ESR1 0.0239
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0238
696 Kappa-type opioid receptor OPRK1 0.0232
124 Histamine H2 receptor HRH2 0.0232
847 Mu-type opioid receptor OPRM1 0.0228
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0228
731 HIV-1 protease HIV-1 protease 0.0227
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0223
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0221
468 Cytochrome P450 4A11 CYP4A11 0.0216
467 Delta-type opioid receptor OPRD1 0.0211
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.021
6143 Solute carrier family 22 member 7 SLC22A7 0.0208
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0208
474 Acetylcholinesterase ACHE 0.0207
6031 Cytochrome P450 3A43 CYP3A43 0.0203
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0203
891 Dihydropteroate synthase folP 0.02
5359 Dihydropteroate synthase folP 0.02
7175 Dihydropteroate synthase sulI 0.02
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0197
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0196
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0185
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0181
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.018
921 Glutamate receptor 2 GRIA2 0.0179
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0177
122 P2Y purinoceptor 12 P2RY12 0.0177
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0174
16 Adenosine A1 receptor ADORA1 0.0168
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0168
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0164
3947 Xanthine dehydrogenase/oxidase XDH 0.0162
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.016
380 Cytochrome P450 17A1 CYP17A1 0.0156
3086 Plasmepsin-2 Not Available 0.0156
6138 Multidrug resistance protein 3 ABCB4 0.0155
751 Potassium channel subfamily K member 6 KCNK6 0.0153
777 Tumor necrosis factor TNF 0.0153
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0153
6102 Arylamine N-acetyltransferase 2 NAT2 0.0151
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.015
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.015
923 Glutamate receptor 3 GRIA3 0.0149
3426 Glutamine synthetase glnA 0.0149
3987 Glutamine synthetase GLUL 0.0149
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0148
70 Type-1 angiotensin II receptor AGTR1 0.0148
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0147
146 Androgen receptor AR 0.0145
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0144
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0144
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0143
1178 Adenosine A2a receptor ADORA2A 0.0142
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0142
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0141
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0141
172 Potassium channel subfamily K member 1 KCNK1 0.014
1024 Solute carrier family 22 member 11 SLC22A11 0.0139
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0138
828 Phenylalanine-4-hydroxylase PAH 0.0138
3109 Phenylalanine-4-hydroxylase phhA 0.0138
1636 Trace amine-associated receptor 1 TAAR1 0.0134
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0133
1656 CYP2B protein CYP2B 0.0133
6220 Aryl hydrocarbon receptor AHR 0.0132
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.013
1757 Myeloperoxidase MPO 0.013
1517 Beta-3 adrenergic receptor ADRB3 0.0128
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0124
183 Vascular endothelial growth factor A VEGFA 0.0124
3810 Catechol O-methyltransferase COMT 0.0124
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0122
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0122
4116 Dihydropteroate synthetase Not Available 0.012
365 Dihydrofolate reductase DHFR 0.012
2381 Dihydrofolate reductase DFR1 0.012
2833 Dihydrofolate reductase Not Available 0.012
2931 Dihydrofolate reductase folA 0.012
3544 Dihydrofolate reductase folA 0.012
3682 Dihydrofolate reductase folA 0.012
6642 Dihydrofolate reductase folA 0.012
6756 Dihydrofolate reductase dfrA 0.012
811 Translocator protein TSPO 0.0119
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0118
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0118
1010 Cytochrome P450 51A1 CYP51A1 0.0117
6148 Multidrug resistance-associated protein 7 ABCC10 0.0116
482 Glycine receptor subunit alpha-1 GLRA1 0.0115
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0115
6432 Transporter snf 0.0115
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0113
6136 Multidrug resistance-associated protein 5 ABCC5 0.0113
6014 Cytochrome P450 2A13 CYP2A13 0.0112
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.011
571 Melatonin receptor type 1A MTNR1A 0.011
362 Melatonin receptor type 1B MTNR1B 0.011
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0109
427 Substance-P receptor TACR1 0.0108
1374 Natriuretic peptides B NPPB 0.0108
6141 Sodium/bile acid cotransporter SLC10A1 0.0108
1827 Gap junction alpha-1 protein GJA1 0.0108
1908 Vascular cell adhesion protein 1 VCAM1 0.0108
871 Glucocorticoid receptor NR3C1 0.0108
4604 Liver carboxylesterase 1 CES1 0.0107
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0106
504 Mast/stem cell growth factor receptor KIT 0.0105
4122 Histone deacetylase 2 HDAC2 0.0104
4120 NADPH--cytochrome P450 reductase POR 0.0104
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0104
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0103
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0103
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.01
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.01
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.01
844 Epidermal growth factor receptor EGFR 0.0099
153 Dopamine beta-hydroxylase DBH 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0095
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0093
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0092
373 Transthyretin TTR 0.0091
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0091
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.009
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.009
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.009
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.009
6859 Protein S100-A4 S100A4 0.009
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0089
6137 Multidrug resistance-associated protein 6 ABCC6 0.0089
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0089
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0089
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0089
613 Atrial natriuretic peptide receptor A NPR1 0.0089
869 Estrogen receptor beta ESR2 0.0088
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0088
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0087
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0086
407 Vascular endothelial growth factor receptor 2 KDR 0.0085
164 Histamine H4 receptor HRH4 0.0085
592 Carbonic anhydrase 4 CA4 0.0084
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0083
537 ATP synthase delta chain, mitochondrial ATP5D 0.0083
295 Carbonic anhydrase 1 CA1 0.0083
518 Peroxidase/catalase T katG 0.0083
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0082
6151 Monocarboxylate transporter 10 SLC16A10 0.0081
26 Vascular endothelial growth factor receptor 3 FLT4 0.0081
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.008
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.008
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.008
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0079
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0079
32 Vascular endothelial growth factor receptor 1 FLT1 0.0077
161 Tubulin beta chain TUBB 0.0077
312 Tubulin beta chain TUB2 0.0077
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0076
705 Glutamate receptor 1 GRIA1 0.0074
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0073
1618 High affinity nerve growth factor receptor NTRK1 0.0073
228 Beta platelet-derived growth factor receptor PDGFRB 0.0073
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0072
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
6126 Carbonic anhydrase 7 CA7 0.0072
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
823 Fibroblast growth factor receptor 2 FGFR2 0.0071
49 Endothelin B receptor EDNRB 0.007
275 Arachidonate 5-lipoxygenase ALOX5 0.0069
904 Glutathione S-transferase P GSTP1 0.0068
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0068
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0068
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0067
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0067
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0067
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0067
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0067
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0067
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0066
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0066
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0065
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0064
6085 Fatty acid-binding protein, intestinal FABP2 0.0064
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0064
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0064
173 Toll-like receptor 7 TLR7 0.0063
133 Dihydropterate synthase sulI 0.0063
357 Carbonic anhydrase 2 CA2 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
634 Squalene monooxygenase SQLE 0.0062
7196 Squalene monooxygenase ERG1 0.0062
614 Progesterone receptor PGR 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0062
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0062
563 Thyroid peroxidase TPO 0.0062
1192 Sulfotransferase 1A1 SULT1A1 0.0061
1275 Estrogen sulfotransferase SULT1E1 0.0061
444 Alcohol dehydrogenase 1B ADH1B 0.0061
251 Alcohol dehydrogenase 1A ADH1A 0.0061
756 Sex hormone-binding globulin SHBG 0.0061
2112 Toll-like receptor 9 TLR9 0.0061
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0061
4203 Histamine N-methyltransferase HNMT 0.006
4311 tRNA TRDMT1 0.006
4325 tRNA trmD 0.006
4328 tRNA trmD 0.006
1541 Metalloproteinase mmp20 0.006
273 Apoptosis regulator Bcl-2 BCL2 0.0059
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0059
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0058
5880 Thrombopoietin receptor MPL 0.0058
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0057
511 5-hydroxytryptamine 1F receptor HTR1F 0.0057
738 Monocarboxylate transporter 1 SLC16A1 0.0057
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0056
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0056
29 Tubulin beta-1 chain TUBB1 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0055
88 Retinoic acid receptor RXR-beta RXRB 0.0054
6146 High affinity copper uptake protein 1 SLC31A1 0.0054
558 Solute carrier family 12 member 1 SLC12A1 0.0054
1648 Elastin ELN 0.0054
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0054
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0054
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0054
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0054
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0054
6044 Serum paraoxonase/lactonase 3 PON3 0.0053
1629 Transcription factor AP-1 JUN 0.0053
24 Thymidylate synthase TMP1 0.0053
359 Thymidylate synthase TYMS 0.0053
2626 Thymidylate synthase thyA 0.0053
2729 Thymidylate synthase thyA 0.0053
5352 Thymidylate synthase THYA 0.0053
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0052
976 Platelet glycoprotein IX GP9 0.0052
7 Nitric oxide synthase, inducible NOS2 0.0052
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0052
952 Dipeptidyl peptidase 4 DPP4 0.0051
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.005
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
208 DNA-directed RNA polymerase beta' chain rpoC 0.0049
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0049
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0049
1360 Sphingomyelin phosphodiesterase SMPD1 0.0048
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0048
517 Alcohol dehydrogenase 1C ADH1C 0.0047
319 Opioid receptor, sigma 1 OPRS1 0.0047
737 Mineralocorticoid receptor NR3C2 0.0046
1253 Interferon gamma IFNG 0.0046
3808 Dihydropteroate synthase 2 folP2 0.0046
3601 Dihydropteroate synthase 1 folP1 0.0046
3807 Dihydropteroate synthase 1 folP1 0.0046
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0046
2230 Catalase CAT 0.0045
3249 Catalase katA 0.0045
3625 Catalase katA 0.0045
4539 Catalase katA 0.0045
4941 Catalase katB 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
5300 Antigen peptide transporter 1 TAP1 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0044
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0044
3937 Fatty-acid amide hydrolase FAAH 0.0044
390 Adenosine A3 receptor ADORA3 0.0044
6020 Aldehyde oxidase AOX1 0.0044
818 50S ribosomal protein L10 rplJ 0.0043
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0043
3957 Adenosine deaminase ADA 0.0043
3809 Estrogen-related receptor gamma ESRRG 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0041
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
814 Ryanodine receptor 1 RYR1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.004
3404 Exotoxin A eta 0.004
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.004
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
239 Coagulation factor X F10 0.0039
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
3917 Methylenetetrahydrofolate reductase MTHFR 0.0039
694 Matrix protein 2 M 0.0039
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
4103 Proteasome subunit beta type 2 PSMB2 0.0039
4102 Proteasome subunit beta type 5 PSMB5 0.0039
4101 Proteasome subunit beta type 1 PSMB1 0.0039
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0039
6174 50S ribosomal protein L32 rpmF 0.0038
162 Retinoic acid receptor gamma-1 RARG 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
284 DNA-directed RNA polymerase beta chain rpoB 0.0038
5773 DNA-directed RNA polymerase beta chain rpoB 0.0038
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1196 Complement decay-accelerating factor CD55 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
3856 Fibroblast growth factor receptor 3 FGFR3 0.0037
84 Nuclear receptor 0B1 NR0B1 0.0037
908 Glutathione S-transferase theta-1 GSTT1 0.0037
130 Prostacyclin synthase PTGIS 0.0037
268 Adenosine A2b receptor ADORA2B 0.0036
780 Retinoic acid receptor RXR-gamma RXRG 0.0036
2539 Tubulin alpha-1 chain TUBA4A 0.0036
2981 Phospholipase A2, membrane associated PLA2G2A 0.0036
4228 Keratin, type II cytoskeletal 7 KRT7 0.0036
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0036
581 Cytochrome P450 2R1 CYP2R1 0.0036
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0036
291 Nitric-oxide synthase, endothelial NOS3 0.0036
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0036
3913 Glutamic acid decarboxylase GAD65 0.0035
473 L-lactate dehydrogenase A chain LDHA 0.0035
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0035
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0035
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0035
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
469 Annexin A1 ANXA1 0.0034
54 Prothrombin F2 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
1992 Vitamin D-binding protein GC 0.0034
165 FL cytokine receptor FLT3 0.0034
6506 Stathmin-4 STMN4 0.0033
2808 Chloramphenicol acetyltransferase 3 cat3 0.0033
229 Retinoic acid receptor beta RARB 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0032
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0032
2290 ADP-ribosyl cyclase 2 BST1 0.0032
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
1630 Integrin beta-2 ITGB2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.003
33 Cystine/glutamate transporter SLC7A11 0.003
820 Glycine receptor subunit alpha-2 GLRA2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
2417 Chloramphenicol acetyltransferase cat 0.003
3278 Chloramphenicol acetyltransferase cat 0.003
6103 Arylamine N-acetyltransferase 1 NAT1 0.003
2810 Dr hemagglutinin structural subunit draA 0.003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.003
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.003
735 Alanine aminotransferase 1 GPT 0.003
3904 Alanine aminotransferase 2 GPT2 0.003
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0028
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
4192 DNA topoisomerase 2-beta TOP2B 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
5934 Cytochrome P450 26A1 CYP26A1 0.0026
6149 Solute carrier family 22 member 10 SLC22A10 0.0026
85 Growth hormone receptor GHR 0.0025
5787 Angiopoietin-1 receptor TEK 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0025
856 Vitamin D3 receptor VDR 0.0025
358 Cystathionine beta-synthase CBS 0.0025
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
4217 Telomerase reverse transcriptase TERT 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
572 Integrin alpha-L ITGAL 0.0024
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0024
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0024
6070 Nischarin NISCH 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0023
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0023
68 Cannabinoid receptor 1 CNR1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
2298 Cytochrome P450-cam camC 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
1864 RET proto-oncogene RET 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0021
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0021
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0021
1039 Histone deacetylase 9 HDAC9 0.0021
1262 Corticotropin-lipotropin POMC 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
2021 Thrombomodulin THBD 0.002
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
6048 Troponin C, skeletal muscle TNNC2 0.002
1820 Beta-nerve growth factor NGF 0.002
2207 Rhodopsin RHO 0.002
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.002
6043 Putative G-protein coupled receptor 44 GPR44 0.0019
2449 Tubulin alpha-3 chain TUBA1A 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0019
6165 Copper-transporting ATPase 1 ATP7A 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
267 Plasminogen activator inhibitor 1 SERPINE1 0.0019
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0018
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0018
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0018
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0018
1268 Neuropeptide S receptor NPSR1 0.0018
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0018
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
6459 Glycodelin PAEP 0.0018
1341 Histamine H3 receptor HRH3 0.0018
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6218 Pannexin-1 PANX1 0.0017
6221 Steroid hormone receptor ERR1 ESRRA 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6073 Potassium channel subfamily K member 9 KCNK9 0.0016
6072 Potassium channel subfamily K member 3 KCNK3 0.0016
1830 5'-nucleotidase NT5E 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
489 Monocarboxylate transporter 2 SLC16A7 0.0016
760 Fibroblast growth factor 1 FGF1 0.0016
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0016
1243 Cathepsin D CTSD 0.0016
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0016
896 Glutathione S-transferase Mu 1 GSTM1 0.0016
3221 Cytochrome c4 cc4 0.0016
2216 Fibroblast growth factor receptor 4 FGFR4 0.0015
758 Thyroid hormone receptor alpha THRA 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2236 Casein kinase II subunit alpha CSNK2A1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4773 Deoxycytidine kinase DCK 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
6131 Carbonic anhydrase 14 CA14 0.0014
798 Osteocalcin BGLAP 0.0014
2091 Endoplasmin HSP90B1 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
2232 Interleukin-5 IL5 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
1593 Mucin-2 MUC2 0.0014
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0013
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0013
6122 Carbonic anhydrase 3 CA3 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
369 Coagulation factor VII F7 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
5923 Microtubule-associated protein tau MAPT 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
5924 Microtubule-associated protein 4 MAP4 0.0013
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
569 Retinal dehydrogenase 2 ALDH1A2 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
3007 Carbonic anhydrase 12 CA12 0.0012
4205 Carbonic anhydrase 9 CA9 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
1852 Microtubule-associated protein 2 MAP2 0.0012
6824 Tyrosine-protein kinase Lyn LYN 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.001
4237 50S ribosomal protein L22 rplV 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
144 Hemoglobin subunit alpha HBA1 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
997 Protein kinase C beta type PRKCB 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4948 Cytochrome c-553 Not Available 0.0009
4923 Cytochrome c3 DvMF_2499 0.0009
4945 Cytochrome c3 Not Available 0.0009
4949 Cytochrome c3 DVU_3171 0.0009
4968 Cytochrome c3 cytc3 0.0009
4997 Cytochrome c3 SO_2727 0.0009
5219 Cytochrome c3 cyd 0.0009
4902 Nine-heme cytochrome c Ddes_2038 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
1507 Cytochrome c CYCS 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4916 Cyanoglobin glbN 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4943 Cytochrome c6 petJ 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4984 Neuroglobin NGB 0.0004
4909 CooA protein cooA 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4961 Hemophore HasA hasA 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4910 Cytoglobin CYGB 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4972 P450cin cinA 0.0004
3093 Catalase HPII katE 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4952 Catalase/peroxidase katA 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
4920 Peroxidase/catalase katG 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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