DT-Web

DB01191 - Dexfenfluramine


Identification
Name Dexfenfluramine
Accession Number DB01191 (APRD00648)
Type small molecule
Description Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. It was for some years in the mid-1990s approved by the United States Food and Drug Administration for the purposes of weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was withdrawn.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 231.2573
Groups illicit
Monoisotopic Weight 231.123484132
Pharmacology
Indication For the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
Mechanism of action Dexfenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin reuptake. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates.
Absorption Well-absorbed from the gastrointestinal tract.
Protein binding 36%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of overdose include respiratory failure and cardiac arrest leading to death.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acetophenazine Decreased anorexic effect, may increase psychotic symptoms
Chlorpromazine Decreased anorexic effect, may increase psychotic symptoms.
Ethopropazine Decreased anorexic effect, may increase psychotic symptoms
Fluoxetine Risk of serotoninergic syndrome
Fluphenazine Decreased anorexic effect, may increase psychotic symptoms
Fluvoxamine Risk of serotoninergic syndrome
Guanethidine Dexfenfluramine may decrease the effect of guanethidine.
Insulin Aspart Fenfluramine increases the effect of insulin
Insulin Detemir Fenfluramine increases the effect of insulin
Insulin Glulisine Fenfluramine increases the effect of insulin
Isocarboxazid Risk of hypertensive crisis.
Mesoridazine Decreased anorexic effect, may increase psychotic symptoms
Methdilazine Decreased anorexic effect, may increase psychotic symptoms
Methotrimeprazine Decreased anorexic effect, may increase psychotic symptoms
Paroxetine Risk of serotoninergic syndrome
Perphenazine Decreased anorexic effect, may increase psychotic symptoms
Phenelzine Possible hypertensive crisis
Prochlorperazine Decreased anorexic effect, may increase psychotic symptoms.
Promazine Decreased anorexic effect, may increase psychotic symptoms
Promethazine Decreased anorexic effect, may increase pyschotic symptoms.
Propericiazine Decreased anorexic effect, may increase psychotic symptoms.
Propiomazine Decreased anorexic effect, may increase psychotic symptoms
Rasagiline Possible hypertensive crisis
Thiethylperazine Decreased anorexic effect, may increase psychotic symptoms
Thioridazine Decreased anorexic effect, may increase psychotic symptoms
Tranylcypromine Possible hypertensive crisis
Trifluoperazine Decreased anorexic effect, may increase psychotic symptoms
Triflupromazine Decreased anorexic effect, may increase psychotic symptoms
Trimeprazine Decreased anorexic effect, may increase psychotic symptoms
Venlafaxine Risk of serotoninergic syndrome
Food Interactions
  • Take with meals.

Targets


Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions inhibitor
References
  • Eddahibi S, Adnot S, Frisdal E, Levame M, Hamon M, Raffestin B: Dexfenfluramine-associated changes in 5-hydroxytryptamine transporter expression and development of hypoxic pulmonary hypertension in rats. J Pharmacol Exp Ther. 2001 Apr;297(1):148-54. - Pubmed
  • Russell BR, Laverty R: The effect of (R)-HA966 or ACEA 1021 on dexfenfluramine or (S)-MDMA-induced changes in temperature, activity, and neurotoxicity. Pharmacol Biochem Behav. 2001 Mar;68(3):565-74. - Pubmed
  • Rothman RB, Jayanthi S, Wang X, Dersch CM, Cadet JL, Prisinzano T, Rice KC, Baumann MH: High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse. 2003 Dec 1;50(3):233-9. - Pubmed
  • Johnson GJ, Leis LA, Dunlop PC, Weir EK: The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. J Thromb Haemost. 2003 Dec;1(12):2663-8. - Pubmed
  • Wang X, Baumann MH, Xu H, Rothman RB: 3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein. Synapse. 2004 Sep 15;53(4):240-8. - Pubmed
DTHybrid score 0.2998
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions agonist
References
  • Vickers SP, Clifton PG, Dourish CT, Tecott LH: Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice. Psychopharmacology (Berl). 1999 Apr;143(3):309-14. - Pubmed
  • Wilson AW, Costall B, Neill JC: Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system. J Psychopharmacol. 2000;14(4):340-6. - Pubmed
  • Vickers SP, Dourish CT, Kennett GA: Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology. 2001 Aug;41(2):200-9. - Pubmed
  • Tomkins DM, Joharchi N, Tampakeras M, Martin JR, Wichmann J, Higgins GA: An investigation of the role of 5-HT(2C) receptors in modifying ethanol self-administration behaviour. Pharmacol Biochem Behav. 2002 Apr;71(4):735-44. - Pubmed
  • Bickerdike MJ: 5-HT2C receptor agonists as potential drugs for the treatment of obesity. Curr Top Med Chem. 2003;3(8):885-97. - Pubmed
DTHybrid score 0.1924

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5509
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4679
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3271
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4336
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4817
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3265

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.4574
4924 Cytochrome P450 2C8 CYP2C8 0.2313
1588 Multidrug resistance protein 1 ABCB1 0.2067
6030 Cytochrome P450 2B6 CYP2B6 0.201
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1872
4118 Cytochrome P450 3A5 CYP3A5 0.1642
502 5-hydroxytryptamine 2A receptor HTR2A 0.1434
6024 Cytochrome P450 1A1 CYP1A1 0.1411
6107 Cytochrome P450 3A7 CYP3A7 0.1266
713 Sodium-dependent dopamine transporter SLC6A3 0.1169
492 Histamine H1 receptor HRH1 0.1098
831 D(2) dopamine receptor DRD2 0.0922
20 Prostaglandin G/H synthase 1 PTGS1 0.0902
436 5-hydroxytryptamine 2B receptor HTR2B 0.0854
318 Alpha-2A adrenergic receptor ADRA2A 0.0845
556 Alpha-1A adrenergic receptor ADRA1A 0.0838
587 Serum albumin ALB 0.0772
320 5-hydroxytryptamine 1A receptor HTR1A 0.0761
23 D(1A) dopamine receptor DRD1 0.0756
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0722
3941 Amine oxidase [flavin-containing] A MAOA 0.0682
6106 Cytochrome P450 2C18 CYP2C18 0.0668
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0644
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0567
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0566
632 Alpha-1B adrenergic receptor ADRA1B 0.0523
3939 Amine oxidase [flavin-containing] B MAOB 0.0516
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0511
629 Alpha-2B adrenergic receptor ADRA2B 0.051
638 D(3) dopamine receptor DRD3 0.0494
378 Alpha-2C adrenergic receptor ADRA2C 0.0474
766 Beta-2 adrenergic receptor ADRB2 0.0469
3811 Cytochrome P450 19A1 CYP19A1 0.0457
885 5-hydroxytryptamine 1B receptor HTR1B 0.0455
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0452
432 D(4) dopamine receptor DRD4 0.0448
290 Prostaglandin G/H synthase 2 PTGS2 0.0446
450 Muscarinic acetylcholine receptor M4 CHRM4 0.044
725 5-hydroxytryptamine 1D receptor HTR1D 0.0435
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0429
6145 Solute carrier family 22 member 1 SLC22A1 0.0423
6144 Solute carrier family 22 member 2 SLC22A2 0.042
341 5-hydroxytryptamine 3 receptor HTR3A 0.0416
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0413
1729 Solute carrier family 22 member 6 SLC22A6 0.0408
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0378
1898 Cytochrome P450 1B1 CYP1B1 0.0376
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0372
193 Beta-1 adrenergic receptor ADRB1 0.0367
789 Alpha-1D adrenergic receptor ADRA1D 0.0353
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0346
118 Organic cation/carnitine transporter 2 SLC22A5 0.0343
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.034
131 Synaptic vesicular amine transporter SLC18A2 0.0329
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0327
862 Multidrug resistance-associated protein 1 ABCC1 0.0319
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0315
163 D(1B) dopamine receptor DRD5 0.0305
716 5-hydroxytryptamine 7 receptor HTR7 0.0294
260 Cytochrome P450 51 ERG11 0.0279
761 Cytochrome P450 51 ERG11 0.0279
3163 Cytochrome P450 51 cyp51 0.0279
696 Kappa-type opioid receptor OPRK1 0.0272
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0272
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0265
847 Mu-type opioid receptor OPRM1 0.0264
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0263
36 Insulin receptor INSR 0.0258
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0257
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0256
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0248
776 Bile salt export pump ABCB11 0.0244
467 Delta-type opioid receptor OPRD1 0.0243
468 Cytochrome P450 4A11 CYP4A11 0.0241
465 Calmodulin CALM1 0.0241
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0241
6147 Solute carrier family 22 member 3 SLC22A3 0.024
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0236
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0235
136 Estrogen receptor ESR1 0.0227
817 DNA topoisomerase 2-alpha TOP2A 0.0224
94 5-hydroxytryptamine 4 receptor HTR4 0.0222
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.022
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0214
362 Melatonin receptor type 1B MTNR1B 0.0213
571 Melatonin receptor type 1A MTNR1A 0.0213
2164 Multidrug resistance-associated protein 4 ABCC4 0.0213
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0212
6014 Cytochrome P450 2A13 CYP2A13 0.0212
891 Dihydropteroate synthase folP 0.0208
5359 Dihydropteroate synthase folP 0.0208
7175 Dihydropteroate synthase sulI 0.0208
731 HIV-1 protease HIV-1 protease 0.0204
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0203
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0202
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
1256 5-hydroxytryptamine 6 receptor HTR6 0.0198
833 Organic cation/carnitine transporter 1 SLC22A4 0.0198
6031 Cytochrome P450 3A43 CYP3A43 0.0197
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0196
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0194
6143 Solute carrier family 22 member 7 SLC22A7 0.019
1656 CYP2B protein CYP2B 0.019
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0186
6142 Solute carrier family 22 member 8 SLC22A8 0.0182
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0178
6102 Arylamine N-acetyltransferase 2 NAT2 0.0174
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0163
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0163
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.016
482 Glycine receptor subunit alpha-1 GLRA1 0.0158
6432 Transporter snf 0.0156
16 Adenosine A1 receptor ADORA1 0.0154
122 P2Y purinoceptor 12 P2RY12 0.0153
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0151
528 5-hydroxytryptamine 1E receptor HTR1E 0.015
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0149
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0148
477 DNA topoisomerase 4 subunit A parC 0.0147
886 DNA topoisomerase 4 subunit A parC 0.0147
6226 DNA topoisomerase 4 subunit A parC 0.0147
124 Histamine H2 receptor HRH2 0.0146
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0144
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0142
6182 Cytochrome P450 2J2 CYP2J2 0.0141
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.014
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.014
777 Tumor necrosis factor TNF 0.0139
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0136
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0135
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0134
474 Acetylcholinesterase ACHE 0.0133
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0132
1178 Adenosine A2a receptor ADORA2A 0.0129
537 ATP synthase delta chain, mitochondrial ATP5D 0.0129
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0128
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0128
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0126
6220 Aryl hydrocarbon receptor AHR 0.0126
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0123
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0123
3923 Cholinesterase BCHE 0.0123
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0121
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0118
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0117
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0116
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0115
1757 Myeloperoxidase MPO 0.0115
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0114
705 Glutamate receptor 1 GRIA1 0.0112
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0112
6136 Multidrug resistance-associated protein 5 ABCC5 0.0112
70 Type-1 angiotensin II receptor AGTR1 0.0111
1010 Cytochrome P450 51A1 CYP51A1 0.011
2230 Catalase CAT 0.0109
3249 Catalase katA 0.0109
3625 Catalase katA 0.0109
4539 Catalase katA 0.0109
4941 Catalase katB 0.0109
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0108
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0108
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0107
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0107
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0106
251 Alcohol dehydrogenase 1A ADH1A 0.0106
1024 Solute carrier family 22 member 11 SLC22A11 0.0106
380 Cytochrome P450 17A1 CYP17A1 0.0105
3810 Catechol O-methyltransferase COMT 0.0105
146 Androgen receptor AR 0.0104
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0103
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0101
444 Alcohol dehydrogenase 1B ADH1B 0.0101
1636 Trace amine-associated receptor 1 TAAR1 0.01
811 Translocator protein TSPO 0.0099
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0097
518 Peroxidase/catalase T katG 0.0097
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0097
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4604 Liver carboxylesterase 1 CES1 0.0096
4116 Dihydropteroate synthetase Not Available 0.0095
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0095
3947 Xanthine dehydrogenase/oxidase XDH 0.0095
904 Glutathione S-transferase P GSTP1 0.0094
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0094
921 Glutamate receptor 2 GRIA2 0.0094
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0093
871 Glucocorticoid receptor NR3C1 0.0092
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0091
563 Thyroid peroxidase TPO 0.0091
4122 Histone deacetylase 2 HDAC2 0.009
6148 Multidrug resistance-associated protein 7 ABCC10 0.0089
613 Atrial natriuretic peptide receptor A NPR1 0.0089
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0089
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0088
295 Carbonic anhydrase 1 CA1 0.0088
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0088
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0087
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0087
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0087
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0087
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0087
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0087
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0086
365 Dihydrofolate reductase DHFR 0.0086
2381 Dihydrofolate reductase DFR1 0.0086
2833 Dihydrofolate reductase Not Available 0.0086
2931 Dihydrofolate reductase folA 0.0086
3544 Dihydrofolate reductase folA 0.0086
3682 Dihydrofolate reductase folA 0.0086
6642 Dihydrofolate reductase folA 0.0086
6756 Dihydrofolate reductase dfrA 0.0086
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0086
592 Carbonic anhydrase 4 CA4 0.0084
373 Transthyretin TTR 0.0084
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0084
869 Estrogen receptor beta ESR2 0.0083
844 Epidermal growth factor receptor EGFR 0.0083
517 Alcohol dehydrogenase 1C ADH1C 0.0082
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0081
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.008
275 Arachidonate 5-lipoxygenase ALOX5 0.0078
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0077
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0076
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0076
511 5-hydroxytryptamine 1F receptor HTR1F 0.0075
6141 Sodium/bile acid cotransporter SLC10A1 0.0075
1517 Beta-3 adrenergic receptor ADRB3 0.0075
1192 Sulfotransferase 1A1 SULT1A1 0.0075
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0072
6126 Carbonic anhydrase 7 CA7 0.0072
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0072
174 Sigma 1-type opioid receptor SIGMAR1 0.0071
504 Mast/stem cell growth factor receptor KIT 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
6137 Multidrug resistance-associated protein 6 ABCC6 0.0071
4238 50S ribosomal protein L4 rplD 0.007
5578 50S ribosomal protein L4 rplD 0.007
6173 50S ribosomal protein L4 rplD 0.007
6219 50S ribosomal protein L4 rplD 0.007
49 Endothelin B receptor EDNRB 0.007
1275 Estrogen sulfotransferase SULT1E1 0.0069
183 Vascular endothelial growth factor A VEGFA 0.0068
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0068
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0068
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0067
319 Opioid receptor, sigma 1 OPRS1 0.0067
161 Tubulin beta chain TUBB 0.0066
312 Tubulin beta chain TUB2 0.0066
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0066
578 Endothelin-1 receptor EDNRA 0.0066
407 Vascular endothelial growth factor receptor 2 KDR 0.0065
4237 50S ribosomal protein L22 rplV 0.0065
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0065
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0065
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0065
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0065
153 Dopamine beta-hydroxylase DBH 0.0064
173 Toll-like receptor 7 TLR7 0.0063
133 Dihydropterate synthase sulI 0.0063
357 Carbonic anhydrase 2 CA2 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
26 Vascular endothelial growth factor receptor 3 FLT4 0.0061
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0059
823 Fibroblast growth factor receptor 2 FGFR2 0.0059
427 Substance-P receptor TACR1 0.0059
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0059
1618 High affinity nerve growth factor receptor NTRK1 0.0058
32 Vascular endothelial growth factor receptor 1 FLT1 0.0058
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0057
3932 Glutathione S-transferase A2 GSTA2 0.0057
3917 Methylenetetrahydrofolate reductase MTHFR 0.0057
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0056
228 Beta platelet-derived growth factor receptor PDGFRB 0.0056
106 Cannabinoid receptor 2 CNR2 0.0055
164 Histamine H4 receptor HRH4 0.0055
6174 50S ribosomal protein L32 rpmF 0.0054
1360 Sphingomyelin phosphodiesterase SMPD1 0.0053
4120 NADPH--cytochrome P450 reductase POR 0.0053
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0053
2298 Cytochrome P450-cam camC 0.0052
3090 Chitosanase csn 0.0052
68 Cannabinoid receptor 1 CNR1 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
84 Nuclear receptor 0B1 NR0B1 0.0051
614 Progesterone receptor PGR 0.0051
3937 Fatty-acid amide hydrolase FAAH 0.0051
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.005
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0049
634 Squalene monooxygenase SQLE 0.0049
7196 Squalene monooxygenase ERG1 0.0049
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0049
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0048
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0048
738 Monocarboxylate transporter 1 SLC16A1 0.0047
273 Apoptosis regulator Bcl-2 BCL2 0.0047
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0047
3809 Estrogen-related receptor gamma ESRRG 0.0047
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0047
1050 Bile salt sulfotransferase SULT2A1 0.0046
1253 Interferon gamma IFNG 0.0046
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0046
6044 Serum paraoxonase/lactonase 3 PON3 0.0046
6146 High affinity copper uptake protein 1 SLC31A1 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0045
756 Sex hormone-binding globulin SHBG 0.0045
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0044
232 Corticosteroid-binding globulin SERPINA6 0.0044
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0044
390 Adenosine A3 receptor ADORA3 0.0044
4311 tRNA TRDMT1 0.0044
4325 tRNA trmD 0.0044
4328 tRNA trmD 0.0044
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0044
284 DNA-directed RNA polymerase beta chain rpoB 0.0044
5773 DNA-directed RNA polymerase beta chain rpoB 0.0044
818 50S ribosomal protein L10 rplJ 0.0043
7 Nitric oxide synthase, inducible NOS2 0.0043
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0043
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0043
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0043
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0043
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0043
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0043
976 Platelet glycoprotein IX GP9 0.0043
780 Retinoic acid receptor RXR-gamma RXRG 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
24 Thymidylate synthase TMP1 0.0042
359 Thymidylate synthase TYMS 0.0042
2626 Thymidylate synthase thyA 0.0042
2729 Thymidylate synthase thyA 0.0042
5352 Thymidylate synthase THYA 0.0042
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0042
54 Prothrombin F2 0.0042
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0041
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0041
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0041
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0041
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0041
400 Coagulation factor IX F9 0.004
5461 Coagulation factor IX F9 0.004
4203 Histamine N-methyltransferase HNMT 0.004
3404 Exotoxin A eta 0.004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.004
158 Sodium channel protein type 1 subunit alpha SCN1A 0.004
6020 Aldehyde oxidase AOX1 0.004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.004
239 Coagulation factor X F10 0.004
3823 Cytokine receptor common gamma chain IL2RG 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
88 Retinoic acid receptor RXR-beta RXRB 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0038
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1629 Transcription factor AP-1 JUN 0.0038
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0038
3639 Thymidine phosphorylase deoA 0.0037
3936 Thymidine phosphorylase TYMP 0.0037
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0037
3957 Adenosine deaminase ADA 0.0037
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0037
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0037
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0037
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0037
604 Vitamin K-dependent protein Z PROZ 0.0037
6085 Fatty acid-binding protein, intestinal FABP2 0.0037
130 Prostacyclin synthase PTGIS 0.0037
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0036
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0036
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0036
4228 Keratin, type II cytoskeletal 7 KRT7 0.0036
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0036
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0036
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0036
473 L-lactate dehydrogenase A chain LDHA 0.0035
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0035
3808 Dihydropteroate synthase 2 folP2 0.0034
3601 Dihydropteroate synthase 1 folP1 0.0034
3807 Dihydropteroate synthase 1 folP1 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
4217 Telomerase reverse transcriptase TERT 0.0034
712 Tubulin alpha chain TUB1 0.0034
1245 Vitamin K-dependent protein S PROS1 0.0034
422 Vitamin K-dependent protein C PROC 0.0034
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0034
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0034
1374 Natriuretic peptides B NPPB 0.0034
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0033
1827 Gap junction alpha-1 protein GJA1 0.0033
1908 Vascular cell adhesion protein 1 VCAM1 0.0033
4226 Uridine phosphorylase 2 UPP2 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
6506 Stathmin-4 STMN4 0.0033
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0033
5934 Cytochrome P450 26A1 CYP26A1 0.0033
1648 Elastin ELN 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0032
2290 ADP-ribosyl cyclase 2 BST1 0.0032
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0032
1268 Neuropeptide S receptor NPSR1 0.0032
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0032
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0032
814 Ryanodine receptor 1 RYR1 0.0032
2981 Phospholipase A2, membrane associated PLA2G2A 0.0032
459 Retinoic acid receptor RXR-alpha RXRA 0.0032
737 Mineralocorticoid receptor NR3C2 0.0031
908 Glutathione S-transferase theta-1 GSTT1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0031
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0031
4225 Uridine phosphorylase 1 UPP1 0.0031
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.003
33 Cystine/glutamate transporter SLC7A11 0.003
820 Glycine receptor subunit alpha-2 GLRA2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
448 Vitamin K-dependent gamma-carboxylase GGCX 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
4103 Proteasome subunit beta type 2 PSMB2 0.0029
4102 Proteasome subunit beta type 5 PSMB5 0.0029
4101 Proteasome subunit beta type 1 PSMB1 0.0029
6073 Potassium channel subfamily K member 9 KCNK9 0.0029
6072 Potassium channel subfamily K member 3 KCNK3 0.0029
6138 Multidrug resistance protein 3 ABCB4 0.0029
469 Annexin A1 ANXA1 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0028
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0028
268 Adenosine A2b receptor ADORA2B 0.0028
208 DNA-directed RNA polymerase beta' chain rpoC 0.0028
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0028
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0028
1039 Histone deacetylase 9 HDAC9 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
798 Osteocalcin BGLAP 0.0028
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0027
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0027
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
952 Dipeptidyl peptidase 4 DPP4 0.0026
2320 Thymidine kinase, cytosolic TK1 0.0026
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
29 Tubulin beta-1 chain TUBB1 0.0026
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0026
85 Growth hormone receptor GHR 0.0025
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0025
5880 Thrombopoietin receptor MPL 0.0025
3830 Calreticulin CALR 0.0025
369 Coagulation factor VII F7 0.0025
1541 Metalloproteinase mmp20 0.0025
581 Cytochrome P450 2R1 CYP2R1 0.0025
3913 Glutamic acid decarboxylase GAD65 0.0024
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0024
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6070 Nischarin NISCH 0.0024
291 Nitric-oxide synthase, endothelial NOS3 0.0024
358 Cystathionine beta-synthase CBS 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
1196 Complement decay-accelerating factor CD55 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1992 Vitamin D-binding protein GC 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
162 Retinoic acid receptor gamma-1 RARG 0.0023
719 Retinoic acid receptor responder protein 1 RARRES1 0.0023
770 Retinoic acid-induced protein 3 GPRC5A 0.0023
1483 Membrane copper amine oxidase AOC3 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
751 Potassium channel subfamily K member 6 KCNK6 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
2207 Rhodopsin RHO 0.0022
2539 Tubulin alpha-1 chain TUBA4A 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
1630 Integrin beta-2 ITGB2 0.0022
1864 RET proto-oncogene RET 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0021
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0021
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0021
165 FL cytokine receptor FLT3 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0021
5300 Antigen peptide transporter 1 TAP1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6149 Solute carrier family 22 member 10 SLC22A10 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
735 Alanine aminotransferase 1 GPT 0.002
3904 Alanine aminotransferase 2 GPT2 0.002
172 Potassium channel subfamily K member 1 KCNK1 0.002
2808 Chloramphenicol acetyltransferase 3 cat3 0.002
569 Retinal dehydrogenase 2 ALDH1A2 0.002
1820 Beta-nerve growth factor NGF 0.002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.002
4192 DNA topoisomerase 2-beta TOP2B 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
6043 Putative G-protein coupled receptor 44 GPR44 0.0019
2449 Tubulin alpha-3 chain TUBA1A 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0019
6165 Copper-transporting ATPase 1 ATP7A 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
2417 Chloramphenicol acetyltransferase cat 0.0018
3278 Chloramphenicol acetyltransferase cat 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
2810 Dr hemagglutinin structural subunit draA 0.0018
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0018
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
1341 Histamine H3 receptor HRH3 0.0018
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0017
856 Vitamin D3 receptor VDR 0.0017
828 Phenylalanine-4-hydroxylase PAH 0.0017
3109 Phenylalanine-4-hydroxylase phhA 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
572 Integrin alpha-L ITGAL 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
1830 5'-nucleotidase NT5E 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0016
1243 Cathepsin D CTSD 0.0016
896 Glutathione S-transferase Mu 1 GSTM1 0.0016
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
2236 Casein kinase II subunit alpha CSNK2A1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
4773 Deoxycytidine kinase DCK 0.0014
3221 Cytochrome c4 cc4 0.0014
3086 Plasmepsin-2 Not Available 0.0014
6131 Carbonic anhydrase 14 CA14 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
6122 Carbonic anhydrase 3 CA3 0.0013
5787 Angiopoietin-1 receptor TEK 0.0013
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0013
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6103 Arylamine N-acetyltransferase 1 NAT1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
2021 Thrombomodulin THBD 0.0012
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0012
3007 Carbonic anhydrase 12 CA12 0.0012
4205 Carbonic anhydrase 9 CA9 0.0012
6048 Troponin C, skeletal muscle TNNC2 0.0011
5798 Mitogen-activated protein kinase 11 MAPK11 0.0011
267 Plasminogen activator inhibitor 1 SERPINE1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
6218 Pannexin-1 PANX1 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
6221 Steroid hormone receptor ERR1 ESRRA 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
144 Hemoglobin subunit alpha HBA1 0.001
760 Fibroblast growth factor 1 FGF1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
997 Protein kinase C beta type PRKCB 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
6459 Glycodelin PAEP 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
489 Monocarboxylate transporter 2 SLC16A7 0.0006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
4386 Hemoglobin-like protein HbN glbN 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1507 Cytochrome c CYCS 0.0005
6133 Sodium channel subunit beta-2 SCN2B 0.0005
6134 Sodium channel subunit beta-3 SCN3B 0.0005
6129 Carbonic anhydrase-related protein 11 CA11 0.0005
6132 Sodium channel subunit beta-1 SCN1B 0.0005
6135 Sodium channel subunit beta-4 SCN4B 0.0005
6127 Carbonic anhydrase-related protein CA8 0.0005
6128 Carbonic anhydrase-related protein 10 CA10 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0004
6130 Carbonic anhydrase 13 CA13 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0003
4954 Soluble cytochrome b558 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
5000 HemO hemO 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4984 Neuroglobin NGB 0.0002
4943 Cytochrome c6 petJ 0.0002
4910 Cytoglobin CYGB 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
4935 Cytochrome c-554 cycA1 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4961 Hemophore HasA hasA 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
4990 PpcA ppcA 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
↑