DT-Web

DB00623 - Fluphenazine


Identification
Name Fluphenazine
Accession Number DB00623 (APRD00633)
Type small molecule
Description A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 437.522
Groups approved
Monoisotopic Weight 437.174867774
Pharmacology
Indication For management of manifestations of psychotic disorders.
Mechanism of action Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Atomoxetine Risk of additive CNS depressant effects. Monitor for increased CNS depression during concomitant therapy.
Benzphetamine Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine Fluphenazine may decrease the effect of guanethidine.
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
Metrizamide Increased risk of convulsions
Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Fluphenazine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Terbinafine Terbinafine may reduce the metabolism and clearance of Fluphenazine. Consider alternate therapy or monitor for therapeutic/adverse effects of Fluphenazine if Terbinafine is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects. Similar pharmacologic properties thus combination therapy will worsen the severity of sedative, parkinsonian, and extrapyramidal adverse effects.
Trimethobenzamide Trimethobenzamide and Fluphenazine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine The antihistamine, Triprolidine, may increase the arrhythmogenic effect of the phenothiazine, Fluphenazine. Monitor for symptoms of ventricular arrhythmias. Additive anticholinergic and CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Fluphenazine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Food Interactions
  • Take with food to reduce irritation.
  • Avoid alcohol.

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Hoyberg OJ, Fensbo C, Remvig J, Lingjaerde O, Sloth-Nielsen M, Salvesen I: Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations. Acta Psychiatr Scand. 1993 Dec;88(6):395-402. - Pubmed
  • Qin ZH, Weiss B: Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra. Eur J Pharmacol. 1994 Sep 15;269(1):25-33. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.3776
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Van Kampen JM, Stoessl AJ: Dopamine D(1A) receptor function in a rodent model of tardive dyskinesia. Neuroscience. 2000;101(3):629-35. - Pubmed
  • Cai G, Gurdal H, Smith C, Wang HY, Friedman E: Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein. Mol Pharmacol. 1999 Nov;56(5):989-96. - Pubmed
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
DTHybrid score 0.2939
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions inhibitor
References
  • Mongin AA, Cai Z, Kimelberg HK: Volume-dependent taurine release from cultured astrocytes requires permissive [Ca(2+)](i) and calmodulin. Am J Physiol. 1999 Oct;277(4 Pt 1):C823-32. - Pubmed
  • Kawai M, Nakashima A, Ueno M, Ushimaru T, Aiba K, Doi H, Uritani M: Fission yeast tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature. Curr Genet. 2001 May;39(3):166-74. - Pubmed
  • Edlind T, Smith L, Henry K, Katiyar S, Nickels J: Antifungal activity in Saccharomyces cerevisiae is modulated by calcium signalling. Mol Microbiol. 2002 Oct;46(1):257-68. - Pubmed
  • Nakabayashi H, Komada H, Yoshida T, Takanari H, Izutsu K: Lymphocyte calmodulin and its participation in the stimulation of T lymphocytes by mitogenic lectins. Biol Cell. 1992;75(1):55-9. - Pubmed
  • Kauss H: Sensing of Volume Changes by Poterioochromonas Involves a Ca-Regulated System Which Controls Activation of Isofloridoside-Phosphate Synthase. Plant Physiol. 1981 Aug;68(2):420-424. - Pubmed
DTHybrid score 0.4064

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4475
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3855
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2561

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
DTHybrid score 0.3419

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3402
4757 Cytochrome P450 2C9 CYP2C9 0.1921
6016 Cytochrome P450 2C19 CYP2C19 0.1834
502 5-hydroxytryptamine 2A receptor HTR2A 0.1781
4924 Cytochrome P450 2C8 CYP2C8 0.133
556 Alpha-1A adrenergic receptor ADRA1A 0.1326
4118 Cytochrome P450 3A5 CYP3A5 0.1274
6030 Cytochrome P450 2B6 CYP2B6 0.125
6024 Cytochrome P450 1A1 CYP1A1 0.107
638 D(3) dopamine receptor DRD3 0.1012
318 Alpha-2A adrenergic receptor ADRA2A 0.1003
6107 Cytochrome P450 3A7 CYP3A7 0.0983
320 5-hydroxytryptamine 1A receptor HTR1A 0.0957
432 D(4) dopamine receptor DRD4 0.0911
492 Histamine H1 receptor HRH1 0.0899
590 5-hydroxytryptamine 2C receptor HTR2C 0.0884
163 D(1B) dopamine receptor DRD5 0.0832
632 Alpha-1B adrenergic receptor ADRA1B 0.0813
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0789
5718 Cytochrome P450 2A6 CYP2A6 0.0767
629 Alpha-2B adrenergic receptor ADRA2B 0.0713
587 Serum albumin ALB 0.069
378 Alpha-2C adrenergic receptor ADRA2C 0.0669
6145 Solute carrier family 22 member 1 SLC22A1 0.0647
824 Sodium-dependent serotonin transporter SLC6A4 0.0586
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0562
436 5-hydroxytryptamine 2B receptor HTR2B 0.0535
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0531
725 5-hydroxytryptamine 1D receptor HTR1D 0.053
885 5-hydroxytryptamine 1B receptor HTR1B 0.0528
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0526
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0498
540 Sodium-dependent noradrenaline transporter SLC6A2 0.049
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0485
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0464
274 Muscarinic acetylcholine receptor M5 CHRM5 0.046
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0447
3923 Cholinesterase BCHE 0.0423
193 Beta-1 adrenergic receptor ADRB1 0.0394
789 Alpha-1D adrenergic receptor ADRA1D 0.0377
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0373
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0372
6144 Solute carrier family 22 member 2 SLC22A2 0.037
20 Prostaglandin G/H synthase 1 PTGS1 0.037
716 5-hydroxytryptamine 7 receptor HTR7 0.0369
766 Beta-2 adrenergic receptor ADRB2 0.0367
3941 Amine oxidase [flavin-containing] A MAOA 0.0361
1507 Cytochrome c CYCS 0.0356
722 Troponin I, cardiac muscle TNNI3 0.0347
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0327
6106 Cytochrome P450 2C18 CYP2C18 0.0322
862 Multidrug resistance-associated protein 1 ABCC1 0.0319
1898 Cytochrome P450 1B1 CYP1B1 0.0309
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0303
3811 Cytochrome P450 19A1 CYP19A1 0.0293
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0292
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0292
713 Sodium-dependent dopamine transporter SLC6A3 0.0284
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0271
118 Organic cation/carnitine transporter 2 SLC22A5 0.0263
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0261
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0261
36 Insulin receptor INSR 0.0258
341 5-hydroxytryptamine 3 receptor HTR3A 0.0258
1729 Solute carrier family 22 member 6 SLC22A6 0.0247
1256 5-hydroxytryptamine 6 receptor HTR6 0.0241
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0232
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0232
3939 Amine oxidase [flavin-containing] B MAOB 0.023
776 Bile salt export pump ABCB11 0.0226
847 Mu-type opioid receptor OPRM1 0.0223
290 Prostaglandin G/H synthase 2 PTGS2 0.0218
817 DNA topoisomerase 2-alpha TOP2A 0.0218
6147 Solute carrier family 22 member 3 SLC22A3 0.0216
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.021
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0208
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0206
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0198
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0196
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0196
467 Delta-type opioid receptor OPRD1 0.0185
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0181
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.018
696 Kappa-type opioid receptor OPRK1 0.018
136 Estrogen receptor ESR1 0.0179
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0178
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0174
6048 Troponin C, skeletal muscle TNNC2 0.0169
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0168
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0167
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0166
3947 Xanthine dehydrogenase/oxidase XDH 0.0166
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0165
477 DNA topoisomerase 4 subunit A parC 0.0163
886 DNA topoisomerase 4 subunit A parC 0.0163
6226 DNA topoisomerase 4 subunit A parC 0.0163
260 Cytochrome P450 51 ERG11 0.0162
761 Cytochrome P450 51 ERG11 0.0162
3163 Cytochrome P450 51 cyp51 0.0162
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0161
6859 Protein S100-A4 S100A4 0.0161
404 DNA gyrase subunit A gyrA 0.016
6224 DNA gyrase subunit A gyrA 0.016
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0158
833 Organic cation/carnitine transporter 1 SLC22A4 0.0157
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0153
16 Adenosine A1 receptor ADORA1 0.015
474 Acetylcholinesterase ACHE 0.0149
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0143
871 Glucocorticoid receptor NR3C1 0.0142
528 5-hydroxytryptamine 1E receptor HTR1E 0.0141
6142 Solute carrier family 22 member 8 SLC22A8 0.0139
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0135
482 Glycine receptor subunit alpha-1 GLRA1 0.0135
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0134
1178 Adenosine A2a receptor ADORA2A 0.0133
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0133
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0132
731 HIV-1 protease HIV-1 protease 0.0131
94 5-hydroxytryptamine 4 receptor HTR4 0.013
2164 Multidrug resistance-associated protein 4 ABCC4 0.013
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.013
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0129
124 Histamine H2 receptor HRH2 0.0129
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0128
6143 Solute carrier family 22 member 7 SLC22A7 0.0128
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0128
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0127
537 ATP synthase delta chain, mitochondrial ATP5D 0.0127
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0126
705 Glutamate receptor 1 GRIA1 0.0124
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
131 Synaptic vesicular amine transporter SLC18A2 0.0123
468 Cytochrome P450 4A11 CYP4A11 0.0122
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0122
777 Tumor necrosis factor TNF 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0118
380 Cytochrome P450 17A1 CYP17A1 0.0117
2795 Methionine aminopeptidase 2 METAP2 0.0117
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0113
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0106
5682 Ribonuclease pancreatic RNASE1 0.0104
4604 Liver carboxylesterase 1 CES1 0.0104
6031 Cytochrome P450 3A43 CYP3A43 0.0103
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0101
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0099
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0099
1757 Myeloperoxidase MPO 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
2132 Protein S100-B S100B 0.0096
6182 Cytochrome P450 2J2 CYP2J2 0.0095
571 Melatonin receptor type 1A MTNR1A 0.0094
362 Melatonin receptor type 1B MTNR1B 0.0094
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0093
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0093
6148 Multidrug resistance-associated protein 7 ABCC10 0.0093
6220 Aryl hydrocarbon receptor AHR 0.0091
1192 Sulfotransferase 1A1 SULT1A1 0.009
613 Atrial natriuretic peptide receptor A NPR1 0.0089
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0088
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0087
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0087
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0085
174 Sigma 1-type opioid receptor SIGMAR1 0.0085
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0085
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0083
921 Glutamate receptor 2 GRIA2 0.0082
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0082
1262 Corticotropin-lipotropin POMC 0.0081
844 Epidermal growth factor receptor EGFR 0.0081
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0081
4122 Histone deacetylase 2 HDAC2 0.0079
869 Estrogen receptor beta ESR2 0.0079
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0078
161 Tubulin beta chain TUBB 0.0078
312 Tubulin beta chain TUB2 0.0078
1010 Cytochrome P450 51A1 CYP51A1 0.0077
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0077
122 P2Y purinoceptor 12 P2RY12 0.0077
504 Mast/stem cell growth factor receptor KIT 0.0076
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0076
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0076
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0074
923 Glutamate receptor 3 GRIA3 0.0074
3810 Catechol O-methyltransferase COMT 0.0074
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0073
153 Dopamine beta-hydroxylase DBH 0.0072
6102 Arylamine N-acetyltransferase 2 NAT2 0.0072
6141 Sodium/bile acid cotransporter SLC10A1 0.0072
244 Angiotensin-converting enzyme ACE 0.0071
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
6014 Cytochrome P450 2A13 CYP2A13 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.007
6137 Multidrug resistance-associated protein 6 ABCC6 0.0069
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0067
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0067
6766 O-GlcNAcase BT_4395 BT_4395 0.0066
373 Transthyretin TTR 0.0066
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0065
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0065
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0065
737 Mineralocorticoid receptor NR3C2 0.0064
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0064
2616 Ganglioside GM2 activator GM2A 0.0063
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
173 Toll-like receptor 7 TLR7 0.0063
1024 Solute carrier family 22 member 11 SLC22A11 0.0063
4120 NADPH--cytochrome P450 reductase POR 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0062
3830 Calreticulin CALR 0.0062
6136 Multidrug resistance-associated protein 5 ABCC5 0.0061
427 Substance-P receptor TACR1 0.006
26 Vascular endothelial growth factor receptor 3 FLT4 0.006
511 5-hydroxytryptamine 1F receptor HTR1F 0.0058
6035 Nuclear receptor ROR-beta RORB 0.0058
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0058
6034 Hydroxyindole O-methyltransferase ASMT 0.0058
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0058
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0058
6036 Eosinophil peroxidase EPX 0.0058
32 Vascular endothelial growth factor receptor 1 FLT1 0.0058
952 Dipeptidyl peptidase 4 DPP4 0.0057
228 Beta platelet-derived growth factor receptor PDGFRB 0.0057
818 50S ribosomal protein L10 rplJ 0.0057
365 Dihydrofolate reductase DHFR 0.0057
2381 Dihydrofolate reductase DFR1 0.0057
2833 Dihydrofolate reductase Not Available 0.0057
2931 Dihydrofolate reductase folA 0.0057
3544 Dihydrofolate reductase folA 0.0057
3682 Dihydrofolate reductase folA 0.0057
6642 Dihydrofolate reductase folA 0.0057
6756 Dihydrofolate reductase dfrA 0.0057
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0056
3426 Glutamine synthetase glnA 0.0056
3987 Glutamine synthetase GLUL 0.0056
1656 CYP2B protein CYP2B 0.0056
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0056
2112 Toll-like receptor 9 TLR9 0.0055
614 Progesterone receptor PGR 0.0055
2449 Tubulin alpha-3 chain TUBA1A 0.0054
1517 Beta-3 adrenergic receptor ADRB3 0.0054
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0054
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0054
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0053
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0053
407 Vascular endothelial growth factor receptor 2 KDR 0.0053
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0053
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0053
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0053
444 Alcohol dehydrogenase 1B ADH1B 0.0053
904 Glutathione S-transferase P GSTP1 0.0052
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0052
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0052
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0052
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0051
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0051
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0051
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0051
6432 Transporter snf 0.0051
811 Translocator protein TSPO 0.0051
694 Matrix protein 2 M 0.0051
70 Type-1 angiotensin II receptor AGTR1 0.0051
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0051
765 Indoleamine 2,3-dioxygenase IDO1 0.0051
6151 Monocarboxylate transporter 10 SLC16A10 0.005
891 Dihydropteroate synthase folP 0.005
5359 Dihydropteroate synthase folP 0.005
7175 Dihydropteroate synthase sulI 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
146 Androgen receptor AR 0.0049
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0048
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
273 Apoptosis regulator Bcl-2 BCL2 0.0048
251 Alcohol dehydrogenase 1A ADH1A 0.0048
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0047
6138 Multidrug resistance protein 3 ABCB4 0.0046
2499 Tubulin beta-2C chain TUBB2C 0.0046
319 Opioid receptor, sigma 1 OPRS1 0.0044
390 Adenosine A3 receptor ADORA3 0.0044
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0044
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0044
3957 Adenosine deaminase ADA 0.0043
756 Sex hormone-binding globulin SHBG 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0042
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0042
518 Peroxidase/catalase T katG 0.0042
1629 Transcription factor AP-1 JUN 0.0041
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0041
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0041
164 Histamine H4 receptor HRH4 0.0041
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0041
4238 50S ribosomal protein L4 rplD 0.004
5578 50S ribosomal protein L4 rplD 0.004
6173 50S ribosomal protein L4 rplD 0.004
6219 50S ribosomal protein L4 rplD 0.004
65 Matrix metalloproteinase-9 Not Available 0.004
3404 Exotoxin A eta 0.004
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.004
29 Tubulin beta-1 chain TUBB1 0.004
563 Thyroid peroxidase TPO 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
738 Monocarboxylate transporter 1 SLC16A1 0.0039
823 Fibroblast growth factor receptor 2 FGFR2 0.0039
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0039
517 Alcohol dehydrogenase 1C ADH1C 0.0039
6044 Serum paraoxonase/lactonase 3 PON3 0.0038
117 Sterol O-acyltransferase 1 SOAT1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0038
4148 Serine/threonine-protein kinase mTOR MTOR 0.0038
4237 50S ribosomal protein L22 rplV 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0036
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0036
6085 Fatty acid-binding protein, intestinal FABP2 0.0036
3932 Glutathione S-transferase A2 GSTA2 0.0036
4228 Keratin, type II cytoskeletal 7 KRT7 0.0036
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0036
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0035
473 L-lactate dehydrogenase A chain LDHA 0.0035
239 Coagulation factor X F10 0.0035
908 Glutathione S-transferase theta-1 GSTT1 0.0035
4311 tRNA TRDMT1 0.0035
4325 tRNA trmD 0.0035
4328 tRNA trmD 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6755 Poliovirus receptor PVR 0.0034
295 Carbonic anhydrase 1 CA1 0.0034
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
976 Platelet glycoprotein IX GP9 0.0034
4116 Dihydropteroate synthetase Not Available 0.0033
6506 Stathmin-4 STMN4 0.0033
1374 Natriuretic peptides B NPPB 0.0033
1827 Gap junction alpha-1 protein GJA1 0.0033
1908 Vascular cell adhesion protein 1 VCAM1 0.0033
1050 Bile salt sulfotransferase SULT2A1 0.0033
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0033
6126 Carbonic anhydrase 7 CA7 0.0032
2290 ADP-ribosyl cyclase 2 BST1 0.0032
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0032
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0032
814 Ryanodine receptor 1 RYR1 0.0032
3856 Fibroblast growth factor receptor 3 FGFR3 0.0032
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0031
6146 High affinity copper uptake protein 1 SLC31A1 0.0031
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0031
3917 Methylenetetrahydrofolate reductase MTHFR 0.0031
1618 High affinity nerve growth factor receptor NTRK1 0.0031
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.003
4203 Histamine N-methyltransferase HNMT 0.0029
768 FK506-binding protein 1A FKBP1A 0.0029
4192 DNA topoisomerase 2-beta TOP2B 0.0029
3937 Fatty-acid amide hydrolase FAAH 0.0029
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0029
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0029
6020 Aldehyde oxidase AOX1 0.0029
284 DNA-directed RNA polymerase beta chain rpoB 0.0029
5773 DNA-directed RNA polymerase beta chain rpoB 0.0029
723 Cytosolic phospholipase A2 PLA2G4A 0.0029
683 Potassium transporter GK0582 0.0029
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0028
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
634 Squalene monooxygenase SQLE 0.0028
7196 Squalene monooxygenase ERG1 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
2297 Genome polyprotein Not Available 0.0027
2322 Genome polyprotein Not Available 0.0027
2694 Genome polyprotein Not Available 0.0027
2719 Genome polyprotein Not Available 0.0027
2860 Genome polyprotein Not Available 0.0027
2928 Genome polyprotein Not Available 0.0027
3160 Genome polyprotein Not Available 0.0027
3260 Genome polyprotein Not Available 0.0027
4783 Genome polyprotein Not Available 0.0027
5726 Genome polyprotein Not Available 0.0027
5779 Genome polyprotein Not Available 0.0027
5867 Genome polyprotein Not Available 0.0027
6253 Genome polyprotein Not Available 0.0027
6301 Genome polyprotein Not Available 0.0027
6380 Genome polyprotein Not Available 0.0027
6381 Genome polyprotein Not Available 0.0027
6437 Genome polyprotein Not Available 0.0027
6520 Genome polyprotein Not Available 0.0027
6521 Genome polyprotein Not Available 0.0027
6652 Genome polyprotein Not Available 0.0027
6734 Genome polyprotein Not Available 0.0027
6735 Genome polyprotein Not Available 0.0027
6736 Genome polyprotein Not Available 0.0027
6737 Genome polyprotein Not Available 0.0027
6738 Genome polyprotein Not Available 0.0027
6739 Genome polyprotein Not Available 0.0027
6744 Genome polyprotein Not Available 0.0027
6748 Genome polyprotein Not Available 0.0027
6894 Genome polyprotein Not Available 0.0027
6898 Genome polyprotein Not Available 0.0027
165 FL cytokine receptor FLT3 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0026
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
592 Carbonic anhydrase 4 CA4 0.0026
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
183 Vascular endothelial growth factor A VEGFA 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
4210 Toll-like receptor 4 TLR4 0.0026
6316 ADP-ribosylation factor 1 ARF1 0.0026
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0025
6228 Nuclear receptor coactivator 1 NCOA1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
7 Nitric oxide synthase, inducible NOS2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
24 Thymidylate synthase TMP1 0.0025
359 Thymidylate synthase TYMS 0.0025
2626 Thymidylate synthase thyA 0.0025
2729 Thymidylate synthase thyA 0.0025
5352 Thymidylate synthase THYA 0.0025
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0025
275 Arachidonate 5-lipoxygenase ALOX5 0.0024
185 Vasopressin V1a receptor AVPR1A 0.0024
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
6070 Nischarin NISCH 0.0024
1275 Estrogen sulfotransferase SULT1E1 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
232 Corticosteroid-binding globulin SERPINA6 0.0023
358 Cystathionine beta-synthase CBS 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0022
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0022
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
751 Potassium channel subfamily K member 6 KCNK6 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
3809 Estrogen-related receptor gamma ESRRG 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0021
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0021
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0021
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
469 Annexin A1 ANXA1 0.0021
33 Cystine/glutamate transporter SLC7A11 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6167 Organic solute transporter subunit beta OSTB 0.0021
6166 Organic solute transporter subunit alpha OSTA 0.0021
1360 Sphingomyelin phosphodiesterase SMPD1 0.0021
6824 Tyrosine-protein kinase Lyn LYN 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
144 Hemoglobin subunit alpha HBA1 0.002
2298 Cytochrome P450-cam camC 0.002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.002
172 Potassium channel subfamily K member 1 KCNK1 0.002
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
1820 Beta-nerve growth factor NGF 0.002
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.002
5961 Insulin INS 0.002
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
357 Carbonic anhydrase 2 CA2 0.0019
4773 Deoxycytidine kinase DCK 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0019
6165 Copper-transporting ATPase 1 ATP7A 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
6459 Glycodelin PAEP 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0019
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0018
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
1714 Mitogen-activated protein kinase 3 MAPK3 0.0018
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0018
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0018
1650 Heme carrier protein 1 SLC46A1 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
229 Retinoic acid receptor beta RARB 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
1648 Elastin ELN 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
54 Prothrombin F2 0.0016
1830 5'-nucleotidase NT5E 0.0016
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
6211 Tubulin epsilon chain TUBE1 0.0016
6212 Tubulin gamma-1 chain TUBG1 0.0016
6210 Tubulin delta chain TUBD1 0.0016
1243 Cathepsin D CTSD 0.0016
2599 Tyrosine-protein kinase HCK HCK 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
291 Nitric-oxide synthase, endothelial NOS3 0.0016
896 Glutathione S-transferase Mu 1 GSTM1 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
936 Ephrin type-A receptor 2 EPHA2 0.0015
162 Retinoic acid receptor gamma-1 RARG 0.0015
2408 Tyrosine-protein kinase SYK SYK 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
702 UMP-CMP kinase CMPK1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
1864 RET proto-oncogene RET 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
2236 Casein kinase II subunit alpha CSNK2A1 0.0015
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
84 Nuclear receptor 0B1 NR0B1 0.0015
6043 Putative G-protein coupled receptor 44 GPR44 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
2207 Rhodopsin RHO 0.0014
3086 Plasmepsin-2 Not Available 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
798 Osteocalcin BGLAP 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
2981 Phospholipase A2, membrane associated PLA2G2A 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
2091 Endoplasmin HSP90B1 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0013
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0013
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0013
1268 Neuropeptide S receptor NPSR1 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
3221 Cytochrome c4 cc4 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
1630 Integrin beta-2 ITGB2 0.0013
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0013
5787 Angiopoietin-1 receptor TEK 0.0013
369 Coagulation factor VII F7 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
2802 Endoglucanase G celCCG 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
6131 Carbonic anhydrase 14 CA14 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
572 Integrin alpha-L ITGAL 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
3868 Calcineurin subunit B isoform 2 PPP3R2 0.001
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
997 Protein kinase C beta type PRKCB 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
6122 Carbonic anhydrase 3 CA3 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
2240 Cell division protein kinase 2 CDK2 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
3007 Carbonic anhydrase 12 CA12 0.0009
4205 Carbonic anhydrase 9 CA9 0.0009
1341 Histamine H3 receptor HRH3 0.0008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
4226 Uridine phosphorylase 2 UPP2 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
822 Aldose reductase AKR1B1 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
3587 Gastrotropin FABP6 0.0007
489 Monocarboxylate transporter 2 SLC16A7 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
1992 Vitamin D-binding protein GC 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2021 Thrombomodulin THBD 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
856 Vitamin D3 receptor VDR 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
6218 Pannexin-1 PANX1 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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