DT-Web

DB01577 - Methamphetamine


Identification
Name Methamphetamine
Accession Number DB01577
Type small molecule
Description Methamphetamine is a psychostimulant and sympathomimetic drug. It is a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potential for addiction and abuse.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 149.2328
Groups illicit
Monoisotopic Weight 149.120449485
Pharmacology
Indication For the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity.
Mechanism of action Methamphetamine enters the brain and triggers a cascading release of norepinephrine, dopamine and serotonin. To a lesser extent methamphetamine acts as a dopaminergic and adrenergic reuptake inhibitor and in high concentrations as a monamine oxidase inhibitor (MAOI). The mechanism of action involved in producing the beneficial behavioral changes seen in hyperkinetic children receiving methamphetamine is unknown.
Absorption Methamphetamine is rapidly absorbed from the gastrointestinal tract with peak methamphetamine concentrations occurring in 3.13 to 6.3 hours post ingestion. Methamphetamine is also well absorbed following inhalation and following intranasal administration. It is distributed to most parts of the body. Because methamphetamine has a high lipophilicity it is distributed across the blood brain barrier and crosses the placenta.
Protein binding Not Available
Biotransformation Hepatic. The primary site of metabolism is in the liver by aromatic hydroxylation, N-dealkylation and deamination. At least seven metabolites have been identified in the urine, with the main metabolites being amphetamine (active) and 4-hydroxymethamphetamine. Other minor metabolites include 4-hydroxyamphetamine, norephedrine, and 4-hydroxynorephedrine.
Route of elimination Excretion occurs primarily in the urine, the rate of which is dependent on urine pH. Between 30-54% of an oral dose is excreted in urine as unchanged methamphetamine and 10-23% as unchanged amphetamine. Following an intravenous dose, 45% is excreted as unchanged parent drug and 7% amphetamine.
Toxicity Manifestations of acute overdosage with methamphetamine include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, hyperpyrexia, and rhabdomyolysis. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Fatal poisoning usually terminates in convulsions and coma.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Chlorpromazine Decreased anorexic effect, may increases psychotic symptoms
Fluoxetine Risk of serotoninergic syndrome
Fluphenazine Decreased anorexic effect, may increase psychotic symptoms
Fluvoxamine Risk of serotoninergic syndrome
Guanethidine Methamphetamine may decrease the effect of guanethidine.
Isocarboxazid Possible hypertensive crisis
Mesoridazine Decreased anorexic effect, may increase psychotic symptoms
Methotrimeprazine Decreased anorexic effect, may increase psychotic symptoms
Paroxetine Risk of serotoninergic syndrome
Perphenazine Decreased anorexic effect, may increase psychotic symptoms
Phenelzine Possible hypertensive crisis
Prochlorperazine Decreased anorexic effect, may increase pyschotic symptoms
Promethazine Decreased anorexic effect, may increase pyschotic symptoms
Propericiazine Decreased anorexic effect, may increase pyschotic symptoms
Rasagiline Possible hypertensive crisis
Terbinafine Terbinafine may reduce the metabolism and clearance of Methamphetamine. Consider alternate therapy or monitor for therapeutic/adverse effects of Methamphetamine if Terbinafine is initiated, discontinued or dose changed.
Thioridazine Decreased anorexic effect, may increase psychotic symptoms
Tramadol Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trandolapril Methamphetamine may reduce the efficacy of Trandolapril.
Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the vasopressor effect of the amphetamine, Methamphetamine. Concomitant therapy should be avoided.
Trifluoperazine Decreased anorexic effect, may increase psychotic symptoms
Triprolidine Triprolidine may reduce the sedative effect of the antihistamine, Methamphetamine.
Food Interactions Not Available

Targets


Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Pharmacological action yes
Actions negative modulator
References
  • Escubedo E, Camarasa J, Chipana C, Garcia-Rates S, Pubill D: Involvement of nicotinic receptors in methamphetamine- and MDMA-induced neurotoxicity: pharmacological implications. Int Rev Neurobiol. 2009;88:121-66. - Pubmed
  • Lott DC, Kim SJ, Cook EH Jr, de Wit H: Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology. 2005 Mar;30(3):602-9. - Pubmed
  • Fone KC, Nutt DJ: Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder. Curr Opin Pharmacol. 2005 Feb;5(1):87-93. - Pubmed
  • Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK: Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun;313(3):983-94. Epub 2005 Mar 11. - Pubmed
  • Garcia BG, Wei Y, Moron JA, Lin RZ, Javitch JA, Galli A: Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol. 2005 Jul;68(1):102-9. Epub 2005 Mar 28. - Pubmed
  • Madras BK, Miller GM, Fischman AJ: The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 1;57(11):1397-409. Epub 2005 Jan 5. - Pubmed
  • Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A: Amphetamine induces dopamine efflux through a dopamine transporter channel. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3495-500. Epub 2005 Feb 22. - Pubmed
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
DTHybrid score 0.7872
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action yes
Actions negative modulator
References
  • Numachi Y, Ohara A, Yamashita M, Fukushima S, Kobayashi H, Hata H, Watanabe H, Hall FS, Lesch KP, Murphy DL, Uhl GR, Sora I: Methamphetamine-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters. Eur J Pharmacol. 2007 Oct 31;572(2-3):120-8. Epub 2007 Jun 27. - Pubmed
  • Tellez R, Rocha L, Castillo C, Meneses A: Autoradiographic study of serotonin transporter during memory formation. Behav Brain Res. 2010 Sep 1;212(1):12-26. Epub 2010 Mar 11. - Pubmed
  • Sora I, Li B, Fumushima S, Fukui A, Arime Y, Kasahara Y, Tomita H, Ikeda K: Monoamine transporter as a target molecule for psychostimulants. Int Rev Neurobiol. 2009;85:29-33. - Pubmed
DTHybrid score 0.5904
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions negative modulator
References
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
DTHybrid score 0.7824
Synaptic vesicular amine transporter
Name Synaptic vesicular amine transporter
Gene Name SLC18A2
Pharmacological action yes
Actions inhibitor
References
  • Horton DB, Siripurapu KB, Norrholm SD, Culver JP, Hojahmat M, Beckmann JS, Harrod SB, Deaciuc AG, Bardo MT, Crooks PA, Dwoskin LP: meso-Transdiene Analogs Inhibit Vesicular Monoamine Transporter-2 Function and Methamphetamine-evoked Dopamine Release. J Pharmacol Exp Ther. 2010 Dec 21. - Pubmed
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A: Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. J Neurosci. 1995 May;15(5 Pt 2):4102-8. - Pubmed
  • Yasumoto S, Tamura K, Karasawa J, Hasegawa R, Ikeda K, Yamamoto T, Yamamoto H: Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2. Neurosci Lett. 2009 May 1;454(3):229-32. Epub 2009 Mar 18. - Pubmed
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
DTHybrid score 0.9134
Chromaffin granule amine transporter
Name Chromaffin granule amine transporter
Gene Name SLC18A1
Pharmacological action yes
Actions inhibitor
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Henry JP, Sagne C, Bedet C, Gasnier B: The vesicular monoamine transporter: from chromaffin granule to brain. Neurochem Int. 1998 Mar;32(3):227-46. - Pubmed
  • Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR: New insights into the mechanism of action of amphetamines. Annu Rev Pharmacol Toxicol. 2007;47:681-98. - Pubmed
DTHybrid score Not Available
Trace amine-associated receptor 1
Name Trace amine-associated receptor 1
Gene Name TAAR1
Pharmacological action yes
Actions agonist
References
  • Grandy DK: Trace amine-associated receptor 1-Family archetype or iconoclast? Pharmacol Ther. 2007 Dec;116(3):355-90. Epub 2007 Jul 17. - Pubmed
  • Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C: Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8966-71. Epub 2001 Jul 17. - Pubmed
  • Reese EA, Bunzow JR, Arttamangkul S, Sonders MS, Grandy DK: Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J Pharmacol Exp Ther. 2007 Apr;321(1):178-86. Epub 2007 Jan 11. - Pubmed
  • Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM: Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther. 2007 Apr;321(1):116-27. Epub 2007 Jan 18. - Pubmed
  • Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, Seeman P, Branchek T, Gerald CP: The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes Brain Behav. 2007 Oct;6(7):628-39. Epub 2006 Dec 21. - Pubmed
  • Xie Z, Miller GM: Trace amine-associated receptor 1 is a modulator of the dopamine transporter. J Pharmacol Exp Ther. 2007 Apr;321(1):128-36. Epub 2007 Jan 18. - Pubmed
  • Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK: Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun;313(3):983-94. Epub 2005 Mar 11. - Pubmed
DTHybrid score 0.5485
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action yes
Actions agonist
References
  • Jeng CH, Wang Y: Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons. Psychopharmacology (Berl). 1998 Mar;136(2):132-8. - Pubmed
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Nishio M, Kanda Y, Mizuno K, Watanabe Y: Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8. - Pubmed
DTHybrid score 0.5528
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action yes
Actions agonist
References
  • Jeng CH, Wang Y: Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons. Psychopharmacology (Berl). 1998 Mar;136(2):132-8. - Pubmed
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
DTHybrid score 0.361
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action yes
Actions agonist
References
  • Jeng CH, Wang Y: Methamphetamine modulates GABA-induced electrophysiological depression by alternating noradrenergic actions in cerebellar Purkinje neurons. Psychopharmacology (Berl). 1998 Mar;136(2):132-8. - Pubmed
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
DTHybrid score 0.3568
Amine oxidase [flavin-containing] A
Name Amine oxidase [flavin-containing] A
Gene Name MAOA
Pharmacological action yes
Actions inhibitor
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. - Pubmed
DTHybrid score 0.7085
Amine oxidase [flavin-containing] B
Name Amine oxidase [flavin-containing] B
Gene Name MAOB
Pharmacological action yes
Actions inhibitor
References
  • Sulzer D, Sonders MS, Poulsen NW, Galli A: Mechanisms of neurotransmitter release by amphetamines: a review. Prog Neurobiol. 2005 Apr;75(6):406-33. - Pubmed
  • Ulus IH, Maher TJ, Wurtman RJ: Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors. Biochem Pharmacol. 2000 Jun 15;59(12):1611-21. - Pubmed
DTHybrid score 1.0936

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6187

Transporters


Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions inhibitor
References
  • Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, Ganapathy V: Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem. 1998 Dec 4;273(49):32776-86. - Pubmed
DTHybrid score 0.2688
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Wu X, Prasad PD, Leibach FH, Ganapathy V: cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. - Pubmed
  • Wu X, Huang W, Prasad PD, Seth P, Rajan DP, Leibach FH, Chen J, Conway SJ, Ganapathy V: Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther. 1999 Sep;290(3):1482-92. - Pubmed
DTHybrid score 0.3126

Predictions


Id Partner name Gene Name Score
556 Alpha-1A adrenergic receptor ADRA1A 0.3817
4512 Cytochrome P450 3A4 CYP3A4 0.312
4200 Cytochrome P450 1A2 CYP1A2 0.2442
502 5-hydroxytryptamine 2A receptor HTR2A 0.203
632 Alpha-1B adrenergic receptor ADRA1B 0.1963
1588 Multidrug resistance protein 1 ABCB1 0.1857
6016 Cytochrome P450 2C19 CYP2C19 0.1623
590 5-hydroxytryptamine 2C receptor HTR2C 0.1584
4757 Cytochrome P450 2C9 CYP2C9 0.156
831 D(2) dopamine receptor DRD2 0.1512
6145 Solute carrier family 22 member 1 SLC22A1 0.1501
492 Histamine H1 receptor HRH1 0.1473
23 D(1A) dopamine receptor DRD1 0.1432
320 5-hydroxytryptamine 1A receptor HTR1A 0.1416
6144 Solute carrier family 22 member 2 SLC22A2 0.1412
725 5-hydroxytryptamine 1D receptor HTR1D 0.1135
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.1111
6030 Cytochrome P450 2B6 CYP2B6 0.1108
885 5-hydroxytryptamine 1B receptor HTR1B 0.1068
436 5-hydroxytryptamine 2B receptor HTR2B 0.1061
766 Beta-2 adrenergic receptor ADRB2 0.1043
4118 Cytochrome P450 3A5 CYP3A5 0.1043
163 D(1B) dopamine receptor DRD5 0.1016
638 D(3) dopamine receptor DRD3 0.1016
193 Beta-1 adrenergic receptor ADRB1 0.1001
789 Alpha-1D adrenergic receptor ADRA1D 0.0972
432 D(4) dopamine receptor DRD4 0.0948
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0897
833 Organic cation/carnitine transporter 1 SLC22A4 0.0877
6013 Cytochrome P450 2E1 CYP2E1 0.0845
5718 Cytochrome P450 2A6 CYP2A6 0.0842
6107 Cytochrome P450 3A7 CYP3A7 0.0779
4924 Cytochrome P450 2C8 CYP2C8 0.0775
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0734
1517 Beta-3 adrenergic receptor ADRB3 0.0617
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0554
6024 Cytochrome P450 1A1 CYP1A1 0.0547
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0537
716 5-hydroxytryptamine 7 receptor HTR7 0.0509
6070 Nischarin NISCH 0.048
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0478
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0465
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0459
3923 Cholinesterase BCHE 0.0448
3810 Catechol O-methyltransferase COMT 0.0433
341 5-hydroxytryptamine 3 receptor HTR3A 0.0421
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.04
1729 Solute carrier family 22 member 6 SLC22A6 0.0395
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0389
6142 Solute carrier family 22 member 8 SLC22A8 0.0386
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0384
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0365
474 Acetylcholinesterase ACHE 0.0363
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0353
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0349
587 Serum albumin ALB 0.0334
511 5-hydroxytryptamine 1F receptor HTR1F 0.0331
828 Phenylalanine-4-hydroxylase PAH 0.0322
3109 Phenylalanine-4-hydroxylase phhA 0.0322
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0315
1757 Myeloperoxidase MPO 0.0307
1656 CYP2B protein CYP2B 0.0303
1256 5-hydroxytryptamine 6 receptor HTR6 0.0289
862 Multidrug resistance-associated protein 1 ABCC1 0.0287
6020 Aldehyde oxidase AOX1 0.028
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0268
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0266
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0261
124 Histamine H2 receptor HRH2 0.0254
6106 Cytochrome P450 2C18 CYP2C18 0.0251
3811 Cytochrome P450 19A1 CYP19A1 0.0251
4120 NADPH--cytochrome P450 reductase POR 0.024
2864 Penton protein PIII 0.0236
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0222
776 Bile salt export pump ABCB11 0.0217
696 Kappa-type opioid receptor OPRK1 0.0213
528 5-hydroxytryptamine 1E receptor HTR1E 0.0211
5841 Insulin-like growth factor IB IGF1 0.0206
465 Calmodulin CALM1 0.0203
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0202
467 Delta-type opioid receptor OPRD1 0.0198
847 Mu-type opioid receptor OPRM1 0.0198
146 Androgen receptor AR 0.0197
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0193
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.019
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0184
477 DNA topoisomerase 4 subunit A parC 0.0178
886 DNA topoisomerase 4 subunit A parC 0.0178
6226 DNA topoisomerase 4 subunit A parC 0.0178
404 DNA gyrase subunit A gyrA 0.0175
6224 DNA gyrase subunit A gyrA 0.0175
6432 Transporter snf 0.0173
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0172
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0171
817 DNA topoisomerase 2-alpha TOP2A 0.0164
1024 Solute carrier family 22 member 11 SLC22A11 0.016
159 Penicillin-binding protein 2B penA 0.0158
6121 Penicillin-binding protein 2B penA 0.0158
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0155
1898 Cytochrome P450 1B1 CYP1B1 0.0153
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0152
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0152
273 Apoptosis regulator Bcl-2 BCL2 0.0149
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0145
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0142
164 Histamine H4 receptor HRH4 0.0136
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0136
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0136
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0135
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0131
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0127
624 Guanidinoacetate N-methyltransferase GAMT 0.0125
153 Dopamine beta-hydroxylase DBH 0.0124
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0124
2472 Voltage-gated potassium channel kcsA 0.0121
6366 Voltage-gated potassium channel kcsA 0.0121
6182 Cytochrome P450 2J2 CYP2J2 0.0119
6014 Cytochrome P450 2A13 CYP2A13 0.0118
20 Prostaglandin G/H synthase 1 PTGS1 0.0114
6031 Cytochrome P450 3A43 CYP3A43 0.0114
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0112
161 Tubulin beta chain TUBB 0.011
312 Tubulin beta chain TUB2 0.011
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0109
6143 Solute carrier family 22 member 7 SLC22A7 0.0108
6151 Monocarboxylate transporter 10 SLC16A10 0.0107
738 Monocarboxylate transporter 1 SLC16A1 0.0107
2164 Multidrug resistance-associated protein 4 ABCC4 0.0105
5626 Nucleoside diphosphate kinase B NME2 0.0105
5698 Riboflavin synthase alpha chain ribE 0.0105
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
408 Riboflavin kinase RFK 0.0101
1341 Histamine H3 receptor HRH3 0.0099
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
380 Cytochrome P450 17A1 CYP17A1 0.0099
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0097
5126 Arginase rocF 0.0096
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0096
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0094
342 P protein [Includes: DNA-directed DNA polymerase P 0.0091
612 P protein [Includes: DNA-directed DNA polymerase P 0.0091
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0091
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0091
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0091
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0091
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.009
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0089
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0089
4203 Histamine N-methyltransferase HNMT 0.0088
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0087
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0085
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0085
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0085
5294 Nucleoside diphosphate kinase A NME1 0.0084
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0083
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0083
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0083
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0082
1360 Sphingomyelin phosphodiesterase SMPD1 0.0082
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
3913 Glutamic acid decarboxylase GAD65 0.008
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0078
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
233 Potassium channel subfamily K member 2 KCNK2 0.0077
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0077
1483 Membrane copper amine oxidase AOC3 0.0076
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0075
654 Flavin reductase BLVRB 0.0075
6137 Multidrug resistance-associated protein 6 ABCC6 0.0073
6148 Multidrug resistance-associated protein 7 ABCC10 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0072
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0072
94 5-hydroxytryptamine 4 receptor HTR4 0.0071
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.007
6136 Multidrug resistance-associated protein 5 ABCC5 0.007
904 Glutathione S-transferase P GSTP1 0.007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0068
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0067
737 Mineralocorticoid receptor NR3C2 0.0066
3917 Methylenetetrahydrofolate reductase MTHFR 0.0066
6141 Sodium/bile acid cotransporter SLC10A1 0.0066
2300 Lysozyme E 0.0065
3633 Lysozyme R 0.0065
5597 Lysozyme 17 0.0065
735 Alanine aminotransferase 1 GPT 0.0065
3904 Alanine aminotransferase 2 GPT2 0.0065
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0062
6138 Multidrug resistance protein 3 ABCB4 0.0061
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
694 Matrix protein 2 M 0.0059
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0059
6067 Penicillin binding protein 2a mecA 0.0058
788 Creatine kinase M-type CKM 0.0057
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0057
4604 Liver carboxylesterase 1 CES1 0.0056
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0054
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0054
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0054
769 High-affinity choline transporter 1 SLC5A7 0.0054
3927 Choline transporter-like protein 3 SLC44A3 0.0054
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0054
861 Choline kinase alpha CHKA 0.0054
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0054
1686 Choline transporter-like protein 1 SLC44A1 0.0054
3926 Choline transporter-like protein 2 SLC44A2 0.0054
700 Choline dehydrogenase, mitochondrial CHDH 0.0054
3925 Choline transporter-like protein 4 SLC44A4 0.0054
576 Choline O-acetyltransferase CHAT 0.0054
3922 Phospholipase D2 PLD2 0.0054
3924 Phospholipase D1 PLD1 0.0054
5682 Ribonuclease pancreatic RNASE1 0.0053
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0053
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0053
731 HIV-1 protease HIV-1 protease 0.0052
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.005
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.005
482 Glycine receptor subunit alpha-1 GLRA1 0.0048
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0048
756 Sex hormone-binding globulin SHBG 0.0047
3426 Glutamine synthetase glnA 0.0047
3987 Glutamine synthetase GLUL 0.0047
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0046
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0046
174 Sigma 1-type opioid receptor SIGMAR1 0.0046
29 Tubulin beta-1 chain TUBB1 0.0046
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0046
2112 Toll-like receptor 9 TLR9 0.0044
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0043
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0042
2539 Tubulin alpha-1 chain TUBA4A 0.0042
1618 High affinity nerve growth factor receptor NTRK1 0.0042
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0042
3947 Xanthine dehydrogenase/oxidase XDH 0.0041
357 Carbonic anhydrase 2 CA2 0.0041
500 Monocarboxylate transporter 4 SLC16A3 0.004
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6133 Sodium channel subunit beta-2 SCN2B 0.0038
6134 Sodium channel subunit beta-3 SCN3B 0.0038
6132 Sodium channel subunit beta-1 SCN1B 0.0038
6135 Sodium channel subunit beta-4 SCN4B 0.0038
6127 Carbonic anhydrase-related protein CA8 0.0038
6129 Carbonic anhydrase-related protein 11 CA11 0.0038
6128 Carbonic anhydrase-related protein 10 CA10 0.0038
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0038
844 Epidermal growth factor receptor EGFR 0.0038
319 Opioid receptor, sigma 1 OPRS1 0.0038
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0037
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0036
6146 High affinity copper uptake protein 1 SLC31A1 0.0036
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0036
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0036
4773 Deoxycytidine kinase DCK 0.0036
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0036
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0036
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0036
6130 Carbonic anhydrase 13 CA13 0.0036
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0035
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0035
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0035
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0035
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
702 UMP-CMP kinase CMPK1 0.0034
6126 Carbonic anhydrase 7 CA7 0.0034
6506 Stathmin-4 STMN4 0.0033
173 Toll-like receptor 7 TLR7 0.0033
327 Glutathione reductase gor 0.0033
5110 Glutathione reductase GR2 0.0033
499 Arginine decarboxylase ADC 0.0033
6131 Carbonic anhydrase 14 CA14 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
976 Platelet glycoprotein IX GP9 0.0032
6163 Copper-transporting ATPase 2 ATP7B 0.0032
6165 Copper-transporting ATPase 1 ATP7A 0.0032
136 Estrogen receptor ESR1 0.0031
6168 Solute carrier family 22 member 16 SLC22A16 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
6122 Carbonic anhydrase 3 CA3 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.003
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.003
614 Progesterone receptor PGR 0.0029
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0029
908 Glutathione S-transferase theta-1 GSTT1 0.0029
295 Carbonic anhydrase 1 CA1 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
565 Extracellular calcium-sensing receptor CASR 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
4205 Carbonic anhydrase 9 CA9 0.0028
3007 Carbonic anhydrase 12 CA12 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
558 Solute carrier family 12 member 1 SLC12A1 0.0027
592 Carbonic anhydrase 4 CA4 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
7 Nitric oxide synthase, inducible NOS2 0.0026
896 Glutathione S-transferase Mu 1 GSTM1 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0024
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0024
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0024
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0024
291 Nitric-oxide synthase, endothelial NOS3 0.0023
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
952 Dipeptidyl peptidase 4 DPP4 0.0021
751 Potassium channel subfamily K member 6 KCNK6 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0021
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.002
5756 D-alanyl-D-alanine carboxypeptidase dac 0.002
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.002
365 Dihydrofolate reductase DHFR 0.002
2381 Dihydrofolate reductase DFR1 0.002
2833 Dihydrofolate reductase Not Available 0.002
2931 Dihydrofolate reductase folA 0.002
3544 Dihydrofolate reductase folA 0.002
3682 Dihydrofolate reductase folA 0.002
6642 Dihydrofolate reductase folA 0.002
6756 Dihydrofolate reductase dfrA 0.002
290 Prostaglandin G/H synthase 2 PTGS2 0.0019
172 Potassium channel subfamily K member 1 KCNK1 0.0019
871 Glucocorticoid receptor NR3C1 0.0019
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1178 Adenosine A2a receptor ADORA2A 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
6085 Fatty acid-binding protein, intestinal FABP2 0.0018
4486 Phenol 2-hydroxylase component B pheA2 0.0018
4477 Dihydrolipoyl dehydrogenase lpdV 0.0018
5077 Dihydrolipoyl dehydrogenase Not Available 0.0018
5117 Dihydrolipoyl dehydrogenase lpd 0.0018
4439 Ferredoxin reductase bphA4 0.0018
5078 Amine oxidase, flavin-containing PSPTO1126 0.0018
526 Thioredoxin reductase trxB 0.0018
3767 Thioredoxin reductase trxB 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
5122 Mersacidin decarboxylase mrsD 0.0017
5095 Putidaredoxin reductase camA 0.0017
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0017
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0017
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0017
5109 Outer membrane protein p64k or PM-6 m-6 0.0017
5115 FkbI fkbI 0.0017
3133 UDP-galactopyranose mutase glf 0.0017
5099 UDP-galactopyranose mutase glf 0.0017
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0017
3763 5,10-methylenetetrahydrofolate reductase metF 0.0017
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0017
5094 5,10-methylenetetrahydrofolate reductase metF 0.0017
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0017
5111 Phenylacetone monooxygenase pamO 0.0017
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0017
5083 Cryptochrome DASH cry 0.0017
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0017
5081 L-aspartate oxidase nadB 0.0017
1410 Oxidoreductase HSD17B6 0.0017
4725 Oxidoreductase Not Available 0.0017
5124 Oxidoreductase Not Available 0.0017
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0017
6218 Pannexin-1 PANX1 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4228 Keratin, type II cytoskeletal 7 KRT7 0.0016
6220 Aryl hydrocarbon receptor AHR 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
468 Cytochrome P450 4A11 CYP4A11 0.0016
1629 Transcription factor AP-1 JUN 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
869 Estrogen receptor beta ESR2 0.0016
4440 NADH peroxidase npr 0.0015
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0015
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0015
3102 Flavohemoprotein hmp 0.0015
4969 Flavohemoprotein hmp 0.0015
3594 Deoxyribodipyrimidine photo-lyase phr 0.0015
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0015
5080 Deoxyribodipyrimidine photo-lyase phr 0.0015
5072 N,N-dimethylglycine oxidase dmg 0.0015
2470 Pyruvate oxidase pox5 0.0015
5073 Ferredoxin--NADP reductase petH 0.0015
5076 Ferredoxin--NADP reductase fpr 0.0015
5119 Ferredoxin--NADP reductase petH 0.0015
5121 Ferredoxin--NADP reductase fpr 0.0015
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0015
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0015
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0015
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0015
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0015
2268 Cholesterol oxidase choB 0.0015
2822 Cholesterol oxidase choA 0.0015
2526 NADPH-ferredoxin reductase fprA fprA 0.0015
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0015
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0015
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0015
6689 TraN protein traN 0.0015
6672 Destrin DSTN 0.0015
6680 Cofilin-1 CFL1 0.0015
6670 Ig kappa chain V-I region Bi Not Available 0.0015
6671 Ig heavy chain V-III region VH26 Not Available 0.0015
4905 Cytochrome c2 Not Available 0.0015
4939 Cytochrome c2 cycA 0.0015
4964 Cytochrome c2 cycA 0.0015
4979 Cytochrome c2 cycA 0.0015
6673 Cytochrome c2 cycA 0.0015
6688 TraF protein traF 0.0015
6404 Rhomboid protease glpG glpG 0.0015
6797 Rhomboid protease glpG glpG 0.0015
3710 Acyl-CoA thioesterase 2 tesB 0.0015
6685 Outer membrane protein II porB 0.0015
6690 BenF-like porin PFL_1329 0.0015
6681 Probable N-acetylneuraminic acid outer membrane channel protein nanC nanC 0.0015
6687 TraO protein traO 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6668 Cytochrome c oxidase subunit 1-beta ctaDII 0.0015
6679 Colicin-Ia cia 0.0015
6676 Fe(3+)-pyochelin receptor fptA 0.0015
6674 Nuclear factor erythroid 2-related factor 1 NFE2L1 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0015
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0015
1050 Bile salt sulfotransferase SULT2A1 0.0014
3086 Plasmepsin-2 Not Available 0.0014
126 D-lactate dehydrogenase dld 0.0014
3545 D-lactate dehydrogenase Not Available 0.0014
4510 D-lactate dehydrogenase ldhA 0.0014
373 Transthyretin TTR 0.0014
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0014
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0014
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0014
2893 Glycine oxidase thiO 0.0014
605 Fumarate reductase flavoprotein subunit frdA 0.0014
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0014
3673 Fumarate reductase flavoprotein subunit fccA 0.0014
4912 Fumarate reductase flavoprotein subunit ifcA 0.0014
6549 Fumarate reductase flavoprotein subunit frdA 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0013
3404 Exotoxin A eta 0.0013
2567 Thymidylate synthase thyX thyX 0.0013
2823 Trypanothione reductase TPR 0.0013
2769 P-hydroxybenzoate hydroxylase pobA 0.0013
2809 P-hydroxybenzoate hydroxylase pobA 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0013
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0013
4760 Mll3241 protein mll3241 0.0013
3395 Iron(III) dicitrate transport protein fecA fecA 0.0013
6385 H subunit of photosynthetic reaction center complex puhA 0.0013
6474 Outer membrane protein W ompW 0.0013
6678 Colicin I receptor cirA 0.0013
3578 Protein crcA crcA 0.0013
6675 Colicin-E3 ceaC 0.0013
2925 Long-chain fatty acid transport protein fadL 0.0013
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0013
6480 Outer membrane usher protein papC papC 0.0013
6438 Outer membrane protein G ompG 0.0013
2447 Ammonia channel amtB 0.0013
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
2380 Monomeric sarcosine oxidase soxA 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6645 D-amino-acid oxidase DAO 0.0012
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.0012
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0012
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0012
6524 Protein tonB tonB 0.0012
2679 Vitamin B12 transporter btuB btuB 0.0012
3856 Fibroblast growth factor receptor 3 FGFR3 0.0012
2207 Rhodopsin RHO 0.0012
228 Beta platelet-derived growth factor receptor PDGFRB 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
76 Nitric-oxide synthase, brain NOS1 0.0012
6102 Arylamine N-acetyltransferase 2 NAT2 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0011
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
6677 Myelin P2 protein PMP2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
489 Monocarboxylate transporter 2 SLC16A7 0.0011
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
407 Vascular endothelial growth factor receptor 2 KDR 0.001
4311 tRNA TRDMT1 0.001
4325 tRNA trmD 0.001
4328 tRNA trmD 0.001
714 Glutathione reductase, mitochondrial GSR 0.001
260 Cytochrome P450 51 ERG11 0.001
761 Cytochrome P450 51 ERG11 0.001
3163 Cytochrome P450 51 cyp51 0.001
144 Hemoglobin subunit alpha HBA1 0.001
6352 Reaction center protein H chain puhA 0.001
6456 Reaction center protein H chain puhA 0.001
6682 Reaction center protein H chain puhA 0.001
6353 Reaction center protein L chain pufL 0.001
6454 Reaction center protein L chain pufL 0.001
6683 Reaction center protein L chain pufL 0.001
518 Peroxidase/catalase T katG 0.001
6354 Reaction center protein M chain pufM 0.001
6455 Reaction center protein M chain pufM 0.001
6684 Reaction center protein M chain pufM 0.001
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.001
777 Tumor necrosis factor TNF 0.0009
2828 Squalene--hopene cyclase shc 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
563 Thyroid peroxidase TPO 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
26 Vascular endothelial growth factor receptor 3 FLT4 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
4122 Histone deacetylase 2 HDAC2 0.0009
16 Adenosine A1 receptor ADORA1 0.0009
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0009
32 Vascular endothelial growth factor receptor 1 FLT1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
3932 Glutathione S-transferase A2 GSTA2 0.0008
537 ATP synthase delta chain, mitochondrial ATP5D 0.0008
1192 Sulfotransferase 1A1 SULT1A1 0.0008
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0008
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0008
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
165 FL cytokine receptor FLT3 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0008
70 Type-1 angiotensin II receptor AGTR1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
122 P2Y purinoceptor 12 P2RY12 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
1992 Vitamin D-binding protein GC 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
4103 Proteasome subunit beta type 2 PSMB2 0.0006
4102 Proteasome subunit beta type 5 PSMB5 0.0006
4101 Proteasome subunit beta type 1 PSMB1 0.0006
1630 Integrin beta-2 ITGB2 0.0006
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
2449 Tubulin alpha-3 chain TUBA1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
268 Adenosine A2b receptor ADORA2B 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
856 Vitamin D3 receptor VDR 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0004
760 Fibroblast growth factor 1 FGF1 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0004
1268 Neuropeptide S receptor NPSR1 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
823 Fibroblast growth factor receptor 2 FGFR2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
3957 Adenosine deaminase ADA 0.0004
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0003
469 Annexin A1 ANXA1 0.0003
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0003
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0003
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0003
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0003
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0003
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0003
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0003
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0003
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0003
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0003
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0002
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