DT-Web

DB01403 - Methotrimeprazine


Identification
Name Methotrimeprazine
Accession Number DB01403
Type small molecule
Description A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 328.472
Groups approved
Monoisotopic Weight 328.16093409
Pharmacology
Indication For the treatment of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder.
Mechanism of action Methotrimeprazine's antipsychotic effect is largely due to its antagonism of dopamine receptors in the brain. In addition, its binding to 5HT2 receptors may also play a role.
Absorption Methotrimeprazine has an incomplete oral bioavailability, because it undergoes considerable first-pass-metabolism in the liver. Oral bioavailability is approximately 50 to 60%.
Protein binding Not Available
Biotransformation Hepatic. Methotrimeprazine is metabolized in the liver and degraded to a sulfoxid-, a glucuronid- and a demethyl-moiety.
Route of elimination Not Available
Toxicity Symptoms of overdose include convulsions, spastic movements, and coma.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Benzphetamine Antipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
Brimonidine Brimonidine may enhance the CNS depressant effect of Methotrimeprazine. Methotrimeprazine may enhance the CNS depressant effect of brimonidine. Consider therapy modification.
Bromazepam Concomitant therapy may result in additive CNS depressant effects. The dosage of bromazepam should be decreased by 50% prior to initiating concomitant therapy. Monitor for increased CNS depression.
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Carisoprodol Carisoprodol, a CNS depressant, may enhance the CNS depressant effect of methotrimeprazine. Methotrimeprazine may enhance the CNS depressant effect of CNS Depressants like carisoprodol. Reduce the dosage of CNS depressants by 50% with initiation of concomitant methotrimeprazine therapy. Further CNS depressant dosage adjustments should be initiated only after clinically effective methotrimeprazine dose has been established. Monitor for increased CNS depression with concomitant therapy.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Dantrolene Concomitant therapy may result in additive CNS depressant effects. The dosage of dantrolene should be decreased by 50% prior to initiating concomitant therapy. Monitor for increased CNS depression.
Dexfenfluramine Decreased anorexic effect, may increase psychotic symptoms
Dextroamphetamine Decreased anorexic effect, may increase psychotic symptoms
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Donepezil Possible antagonism of action
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine Methotrimeprazine may decrease the effect of guanethidine.
Isocarboxazid Possible severe adverse reaction with this combination
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Methamphetamine Decreased anorexic effect, may increase psychotic symptoms
Metrizamide Increased risk of convulsions
Paliperidone The CNS depressant agents, paliperidone and methotrimeprazine, may cause additive CNS depressant effects. Monitor for increased CNS depressant effects during concomitant therapy.
Pargyline Possible severe adverse reaction with this combination
Phendimetrazine Decreased anorexic effect, may increase psychotic symptoms
Phenelzine Possible severe adverse reaction with this combination
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Rivastigmine Possible antagonism of action
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tramadol Additive CNS depressant effects. Decrease dose of tramadol by 50% if initiating methotrimeprazine therapy. Monitor for increased CNS depression and apply further dosage adjustments as required.
Tranylcypromine Possible severe adverse reaction with this combination
Vigabatrin Additive CNS depression may occur. Dose adjustments may be required if one agent is added to existing therapy with the other agent. Monitor for increased CNS depression during concomitant therapy.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Zaleplon Additive CNS depressant effects may occur. A dose reduction of zaleplon may be required. Monitor for increased CNS depression during concomitant therapy.
Ziconotide Additive CNS depressant effects may occur. A dose reduction of ziconotide may be required. Monitor for increased CNS depression during concomitant therapy.
Ziprasidone Additive QTc-prolongation may occur increasing the risk of life-threatening ventricular arrhythmias and torsade de pointes. Concomitant therapy should be avoided.
Zolpidem Additive CNS depressant effects. Reduce zolpidem dose by half upon initiation of methotrimeprazine. Zolpidem dose may be adjusted once methotrimeprazine dose has been established. Monitor for increased CNS depression.
Zonisamide Additive CNS depressant effects. Reduce zonisamide dose by half upon initiation of methotrimeprazine. Zonisamide dose may be adjusted once methotrimeprazine dose has been established. Monitor for increased CNS depression.
Zopiclone Additive CNS depressant effects. Reduce zopiclone dose by half upon initiation of methotrimeprazine. Zopiclone dose may be adjusted once methotrimeprazine dose has been established. Monitor for increased CNS depression.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). Methotrimeprazine, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if methotrimeprazine is initiated, discontinued or dose changed.
Food Interactions
  • Take with food to reduce irritation.

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9373
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
DTHybrid score 0.8094
D(1B) dopamine receptor
Name D(1B) dopamine receptor
Gene Name DRD5
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
DTHybrid score 0.4629
D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
DTHybrid score 0.5352
D(4) dopamine receptor
Name D(4) dopamine receptor
Gene Name DRD4
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
DTHybrid score 0.526
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
DTHybrid score 0.8369
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
DTHybrid score 0.5983
Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action unknown
Actions antagonist
References
  • Hals PA, Hall H, Dahl SG: Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12. - Pubmed
DTHybrid score 0.888
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action unknown
Actions antagonist
References
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Hals PA, Hall H, Dahl SG: Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12. - Pubmed
DTHybrid score 1.0935
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action unknown
Actions antagonist
References
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Hals PA, Hall H, Dahl SG: Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12. - Pubmed
DTHybrid score 0.9342
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action unknown
Actions antagonist
References
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Hals PA, Hall H, Dahl SG: Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12. - Pubmed
DTHybrid score 0.9334
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action unknown
Actions antagonist
References
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Hals PA, Hall H, Dahl SG: Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12. - Pubmed
DTHybrid score 0.7146
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action unknown
Actions antagonist
References
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Hals PA, Hall H, Dahl SG: Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites. Life Sci. 1988;43(5):405-12. - Pubmed
DTHybrid score 0.6192
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
DTHybrid score 0.9576
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
DTHybrid score 0.6807
Alpha-1D adrenergic receptor
Name Alpha-1D adrenergic receptor
Gene Name ADRA1D
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
DTHybrid score 0.4739
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Tsukamoto T, Asakura M, Hirata N, Imafuku J, Matsui H, Hasegawa K: Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action. Biol Psychiatry. 1984 Sep;19(9):1283-91. - Pubmed
DTHybrid score 0.8645
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Tsukamoto T, Asakura M, Hirata N, Imafuku J, Matsui H, Hasegawa K: Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action. Biol Psychiatry. 1984 Sep;19(9):1283-91. - Pubmed
DTHybrid score 0.6312
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action unknown
Actions antagonist
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
  • Dahl SG, Hough E, Hals PA: Phenothiazine drugs and metabolites: molecular conformation and dopaminergic, alpha adrenergic and muscarinic cholinergic receptor binding. Biochem Pharmacol. 1986 Apr 15;35(8):1263-9. - Pubmed
  • Tsukamoto T, Asakura M, Hirata N, Imafuku J, Matsui H, Hasegawa K: Interaction of neuroleptics and antidepressants with rat brain alpha 2-receptors: a possible relationship between alpha 2-receptor antagonism and antidepressant action. Biol Psychiatry. 1984 Sep;19(9):1283-91. - Pubmed
DTHybrid score 0.6074

Enzymes


Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.898
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3391
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Green B, Pettit T, Faith L, Seaton K: Focus on levomepromazine. Curr Med Res Opin. 2004 Dec;20(12):1877-81. - Pubmed
DTHybrid score 0.6332

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.6796
320 5-hydroxytryptamine 1A receptor HTR1A 0.4719
1588 Multidrug resistance protein 1 ABCB1 0.36
725 5-hydroxytryptamine 1D receptor HTR1D 0.3263
4757 Cytochrome P450 2C9 CYP2C9 0.302
6016 Cytochrome P450 2C19 CYP2C19 0.3005
885 5-hydroxytryptamine 1B receptor HTR1B 0.2988
436 5-hydroxytryptamine 2B receptor HTR2B 0.2949
540 Sodium-dependent noradrenaline transporter SLC6A2 0.2501
716 5-hydroxytryptamine 7 receptor HTR7 0.2413
824 Sodium-dependent serotonin transporter SLC6A4 0.2156
4118 Cytochrome P450 3A5 CYP3A5 0.2087
6030 Cytochrome P450 2B6 CYP2B6 0.1791
1256 5-hydroxytryptamine 6 receptor HTR6 0.1741
6145 Solute carrier family 22 member 1 SLC22A1 0.1644
4924 Cytochrome P450 2C8 CYP2C8 0.1608
6107 Cytochrome P450 3A7 CYP3A7 0.1582
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1469
713 Sodium-dependent dopamine transporter SLC6A3 0.1419
3923 Cholinesterase BCHE 0.13
6024 Cytochrome P450 1A1 CYP1A1 0.1276
341 5-hydroxytryptamine 3 receptor HTR3A 0.1211
193 Beta-1 adrenergic receptor ADRB1 0.1204
766 Beta-2 adrenergic receptor ADRB2 0.1196
528 5-hydroxytryptamine 1E receptor HTR1E 0.1148
6144 Solute carrier family 22 member 2 SLC22A2 0.1129
587 Serum albumin ALB 0.1004
3941 Amine oxidase [flavin-containing] A MAOA 0.0972
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0964
5718 Cytochrome P450 2A6 CYP2A6 0.0958
118 Organic cation/carnitine transporter 2 SLC22A5 0.0849
6147 Solute carrier family 22 member 3 SLC22A3 0.0822
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0804
131 Synaptic vesicular amine transporter SLC18A2 0.0789
465 Calmodulin CALM1 0.0755
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0628
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0623
124 Histamine H2 receptor HRH2 0.0597
833 Organic cation/carnitine transporter 1 SLC22A4 0.0558
3939 Amine oxidase [flavin-containing] B MAOB 0.0491
1517 Beta-3 adrenergic receptor ADRB3 0.0463
828 Phenylalanine-4-hydroxylase PAH 0.0457
3109 Phenylalanine-4-hydroxylase phhA 0.0457
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0445
174 Sigma 1-type opioid receptor SIGMAR1 0.0434
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0429
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0421
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0421
6070 Nischarin NISCH 0.0421
20 Prostaglandin G/H synthase 1 PTGS1 0.042
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0412
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0408
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0408
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0402
6106 Cytochrome P450 2C18 CYP2C18 0.0395
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0388
94 5-hydroxytryptamine 4 receptor HTR4 0.0357
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0347
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.034
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0335
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0332
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0327
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0325
1898 Cytochrome P450 1B1 CYP1B1 0.0323
1656 CYP2B protein CYP2B 0.032
2129 Sucrase-isomaltase, intestinal SI 0.0317
6432 Transporter snf 0.0306
474 Acetylcholinesterase ACHE 0.0303
696 Kappa-type opioid receptor OPRK1 0.0301
6151 Monocarboxylate transporter 10 SLC16A10 0.0292
6020 Aldehyde oxidase AOX1 0.0285
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0272
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0267
3811 Cytochrome P450 19A1 CYP19A1 0.0263
36 Insulin receptor INSR 0.0258
1636 Trace amine-associated receptor 1 TAAR1 0.0243
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0243
164 Histamine H4 receptor HRH4 0.0243
6138 Multidrug resistance protein 3 ABCB4 0.0238
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0238
3810 Catechol O-methyltransferase COMT 0.0233
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0228
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0225
467 Delta-type opioid receptor OPRD1 0.0221
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0219
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0217
1729 Solute carrier family 22 member 6 SLC22A6 0.021
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0206
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0205
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.02
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0194
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0191
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0185
1341 Histamine H3 receptor HRH3 0.0184
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0183
3426 Glutamine synthetase glnA 0.0183
3987 Glutamine synthetase GLUL 0.0183
776 Bile salt export pump ABCB11 0.0183
847 Mu-type opioid receptor OPRM1 0.0179
153 Dopamine beta-hydroxylase DBH 0.0178
290 Prostaglandin G/H synthase 2 PTGS2 0.0175
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0174
6100 BDNF/NT-3 growth factors receptor NTRK2 0.017
516 Neurotensin receptor type 2 NTSR2 0.0168
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0166
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0166
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0166
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0163
862 Multidrug resistance-associated protein 1 ABCC1 0.0162
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0157
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0156
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0156
571 Melatonin receptor type 1A MTNR1A 0.0155
362 Melatonin receptor type 1B MTNR1B 0.0155
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0154
817 DNA topoisomerase 2-alpha TOP2A 0.0153
923 Glutamate receptor 3 GRIA3 0.0149
1360 Sphingomyelin phosphodiesterase SMPD1 0.0148
233 Potassium channel subfamily K member 2 KCNK2 0.0146
16 Adenosine A1 receptor ADORA1 0.0145
723 Cytosolic phospholipase A2 PLA2G4A 0.0144
1618 High affinity nerve growth factor receptor NTRK1 0.0142
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0141
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0139
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0139
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0138
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0137
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0132
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0128
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
921 Glutamate receptor 2 GRIA2 0.0127
3947 Xanthine dehydrogenase/oxidase XDH 0.0127
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0126
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0126
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0126
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
6182 Cytochrome P450 2J2 CYP2J2 0.012
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
380 Cytochrome P450 17A1 CYP17A1 0.012
260 Cytochrome P450 51 ERG11 0.012
761 Cytochrome P450 51 ERG11 0.012
3163 Cytochrome P450 51 cyp51 0.012
1178 Adenosine A2a receptor ADORA2A 0.0119
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0118
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0116
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.011
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.011
1275 Estrogen sulfotransferase SULT1E1 0.0105
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0104
468 Cytochrome P450 4A11 CYP4A11 0.0101
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.01
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0099
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0095
777 Tumor necrosis factor TNF 0.0094
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0093
6859 Protein S100-A4 S100A4 0.009
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
613 Atrial natriuretic peptide receptor A NPR1 0.0089
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0089
6031 Cytochrome P450 3A43 CYP3A43 0.0088
6220 Aryl hydrocarbon receptor AHR 0.0087
4120 NADPH--cytochrome P450 reductase POR 0.0086
2164 Multidrug resistance-associated protein 4 ABCC4 0.0085
482 Glycine receptor subunit alpha-1 GLRA1 0.0085
136 Estrogen receptor ESR1 0.0084
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0084
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0082
731 HIV-1 protease HIV-1 protease 0.0082
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.008
904 Glutathione S-transferase P GSTP1 0.008
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0079
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0078
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0075
4122 Histone deacetylase 2 HDAC2 0.0075
537 ATP synthase delta chain, mitochondrial ATP5D 0.0074
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0072
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
6143 Solute carrier family 22 member 7 SLC22A7 0.0069
705 Glutamate receptor 1 GRIA1 0.0068
6102 Arylamine N-acetyltransferase 2 NAT2 0.0068
1757 Myeloperoxidase MPO 0.0068
6014 Cytochrome P450 2A13 CYP2A13 0.0067
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0067
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0067
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0065
1010 Cytochrome P450 51A1 CYP51A1 0.0064
173 Toll-like receptor 7 TLR7 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0062
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0062
6142 Solute carrier family 22 member 8 SLC22A8 0.0059
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0058
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0052
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0051
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0051
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0051
4604 Liver carboxylesterase 1 CES1 0.0051
6148 Multidrug resistance-associated protein 7 ABCC10 0.0051
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.005
891 Dihydropteroate synthase folP 0.005
5359 Dihydropteroate synthase folP 0.005
7175 Dihydropteroate synthase sulI 0.005
6097 Protein S100-A2 S100A2 0.005
1810 Protein S100-A1 S100A1 0.005
427 Substance-P receptor TACR1 0.005
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.005
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
444 Alcohol dehydrogenase 1B ADH1B 0.0049
251 Alcohol dehydrogenase 1A ADH1A 0.0048
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0048
1374 Natriuretic peptides B NPPB 0.0046
1827 Gap junction alpha-1 protein GJA1 0.0046
1908 Vascular cell adhesion protein 1 VCAM1 0.0046
390 Adenosine A3 receptor ADORA3 0.0044
365 Dihydrofolate reductase DHFR 0.0044
2381 Dihydrofolate reductase DFR1 0.0044
2833 Dihydrofolate reductase Not Available 0.0044
2931 Dihydrofolate reductase folA 0.0044
3544 Dihydrofolate reductase folA 0.0044
3682 Dihydrofolate reductase folA 0.0044
6642 Dihydrofolate reductase folA 0.0044
6756 Dihydrofolate reductase dfrA 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0044
871 Glucocorticoid receptor NR3C1 0.0043
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0043
373 Transthyretin TTR 0.0043
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0043
1048 Protein S100-A13 S100A13 0.0043
2226 Protein S100-A12 S100A12 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
511 5-hydroxytryptamine 1F receptor HTR1F 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
518 Peroxidase/catalase T katG 0.0042
811 Translocator protein TSPO 0.0041
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0041
122 P2Y purinoceptor 12 P2RY12 0.004
3404 Exotoxin A eta 0.004
2132 Protein S100-B S100B 0.004
504 Mast/stem cell growth factor receptor KIT 0.004
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0039
563 Thyroid peroxidase TPO 0.0039
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0039
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0039
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0039
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
694 Matrix protein 2 M 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0039
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0039
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0039
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0039
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
4203 Histamine N-methyltransferase HNMT 0.0039
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0038
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0038
869 Estrogen receptor beta ESR2 0.0037
517 Alcohol dehydrogenase 1C ADH1C 0.0037
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0036
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0036
4228 Keratin, type II cytoskeletal 7 KRT7 0.0036
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0036
473 L-lactate dehydrogenase A chain LDHA 0.0035
1192 Sulfotransferase 1A1 SULT1A1 0.0035
183 Vascular endothelial growth factor A VEGFA 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0034
273 Apoptosis regulator Bcl-2 BCL2 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
3957 Adenosine deaminase ADA 0.0034
4116 Dihydropteroate synthetase Not Available 0.0033
6506 Stathmin-4 STMN4 0.0033
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0033
6126 Carbonic anhydrase 7 CA7 0.0032
2290 ADP-ribosyl cyclase 2 BST1 0.0032
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0032
6136 Multidrug resistance-associated protein 5 ABCC5 0.0032
1024 Solute carrier family 22 member 11 SLC22A11 0.0032
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0032
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
295 Carbonic anhydrase 1 CA1 0.0031
228 Beta platelet-derived growth factor receptor PDGFRB 0.0031
26 Vascular endothelial growth factor receptor 3 FLT4 0.0031
844 Epidermal growth factor receptor EGFR 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
823 Fibroblast growth factor receptor 2 FGFR2 0.0031
4311 tRNA TRDMT1 0.0031
4325 tRNA trmD 0.0031
4328 tRNA trmD 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
818 50S ribosomal protein L10 rplJ 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
32 Vascular endothelial growth factor receptor 1 FLT1 0.003
3937 Fatty-acid amide hydrolase FAAH 0.0029
6141 Sodium/bile acid cotransporter SLC10A1 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0029
3917 Methylenetetrahydrofolate reductase MTHFR 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0028
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0028
1050 Bile salt sulfotransferase SULT2A1 0.0028
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
634 Squalene monooxygenase SQLE 0.0028
7196 Squalene monooxygenase ERG1 0.0028
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0028
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0028
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
1629 Transcription factor AP-1 JUN 0.0028
6146 High affinity copper uptake protein 1 SLC31A1 0.0028
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0027
908 Glutathione S-transferase theta-1 GSTT1 0.0027
976 Platelet glycoprotein IX GP9 0.0027
407 Vascular endothelial growth factor receptor 2 KDR 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
592 Carbonic anhydrase 4 CA4 0.0026
814 Ryanodine receptor 1 RYR1 0.0026
284 DNA-directed RNA polymerase beta chain rpoB 0.0026
5773 DNA-directed RNA polymerase beta chain rpoB 0.0026
5880 Thrombopoietin receptor MPL 0.0025
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0025
146 Androgen receptor AR 0.0025
6137 Multidrug resistance-associated protein 6 ABCC6 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
358 Cystathionine beta-synthase CBS 0.0023
268 Adenosine A2b receptor ADORA2B 0.0023
70 Type-1 angiotensin II receptor AGTR1 0.0023
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
275 Arachidonate 5-lipoxygenase ALOX5 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0021
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0021
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0021
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0021
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
319 Opioid receptor, sigma 1 OPRS1 0.002
2298 Cytochrome P450-cam camC 0.002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.002
1820 Beta-nerve growth factor NGF 0.002
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.002
4192 DNA topoisomerase 2-beta TOP2B 0.002
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.002
357 Carbonic anhydrase 2 CA2 0.0019
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2449 Tubulin alpha-3 chain TUBA1A 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0019
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0019
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0019
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0019
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0019
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0019
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
7 Nitric oxide synthase, inducible NOS2 0.0018
543 Penicillin-binding protein 1B mrcB 0.0018
6186 Penicillin-binding protein 1B ponB 0.0018
6822 Penicillin-binding protein 1b pbp1b 0.0018
6844 Penicillin-binding protein 1b pbp1b 0.0018
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
645 Penicillin-binding protein 1A mrcA 0.0018
5805 Penicillin-binding protein 1A ponA 0.0018
6185 Penicillin-binding protein 1A mrcA 0.0018
6799 Penicillin-binding protein 1A pbpA 0.0018
159 Penicillin-binding protein 2B penA 0.0018
6121 Penicillin-binding protein 2B penA 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
751 Potassium channel subfamily K member 6 KCNK6 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
1648 Elastin ELN 0.0017
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0017
239 Coagulation factor X F10 0.0016
738 Monocarboxylate transporter 1 SLC16A1 0.0016
1830 5'-nucleotidase NT5E 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
172 Potassium channel subfamily K member 1 KCNK1 0.0016
1243 Cathepsin D CTSD 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2236 Casein kinase II subunit alpha CSNK2A1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
29 Tubulin beta-1 chain TUBB1 0.0014
3086 Plasmepsin-2 Not Available 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
798 Osteocalcin BGLAP 0.0014
4103 Proteasome subunit beta type 2 PSMB2 0.0014
4102 Proteasome subunit beta type 5 PSMB5 0.0014
4101 Proteasome subunit beta type 1 PSMB1 0.0014
614 Progesterone receptor PGR 0.0014
2091 Endoplasmin HSP90B1 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0013
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0013
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0013
1268 Neuropeptide S receptor NPSR1 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
3809 Estrogen-related receptor gamma ESRRG 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
369 Coagulation factor VII F7 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0012
165 FL cytokine receptor FLT3 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
291 Nitric-oxide synthase, endothelial NOS3 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
84 Nuclear receptor 0B1 NR0B1 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
4237 50S ribosomal protein L22 rplV 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
1864 RET proto-oncogene RET 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.001
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.001
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.001
737 Mineralocorticoid receptor NR3C2 0.001
469 Annexin A1 ANXA1 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
6131 Carbonic anhydrase 14 CA14 0.001
144 Hemoglobin subunit alpha HBA1 0.001
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
760 Fibroblast growth factor 1 FGF1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
997 Protein kinase C beta type PRKCB 0.0009
6122 Carbonic anhydrase 3 CA3 0.0009
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
2207 Rhodopsin RHO 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
3221 Cytochrome c4 cc4 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
3007 Carbonic anhydrase 12 CA12 0.0009
4205 Carbonic anhydrase 9 CA9 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
1262 Corticotropin-lipotropin POMC 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
3830 Calreticulin CALR 0.0008
6459 Glycodelin PAEP 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0008
244 Angiotensin-converting enzyme ACE 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0008
54 Prothrombin F2 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0008
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
4773 Deoxycytidine kinase DCK 0.0007
1992 Vitamin D-binding protein GC 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
1630 Integrin beta-2 ITGB2 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
856 Vitamin D3 receptor VDR 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
6085 Fatty acid-binding protein, intestinal FABP2 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
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