DT-Web

DB00425 - Zolpidem


Identification
Name Zolpidem
Accession Number DB00425 (APRD00095)
Type small molecule
Description Zolpidem is a prescription short-acting nonbenzodiazepine hypnotic that potentiates gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, by binding to benzodiazepine receptors which are located on the gamma-aminobutyric acid receptors. Zolpidem is used for the short-term treatment of insomnia. It works quickly (usually within 15 minutes) and has a short half-life (2-3 hours). It is classified as an imidazopyridine. As an anticonvulsant and muscle relaxant, the beneficial effects start to emerge at 10 and 20 times the dose required for sedation, respectively. For that reason, it has never been approved for either muscle relaxation or seizure prevention. Recently, zolpidem has been cited in various medical reports mainly in the United Kingdom as waking persistent vegetative state (PVS) patients, and dramatically improving the conditions of people with brain injuries. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 307.3895
Groups approved
Monoisotopic Weight 307.168462309
Pharmacology
Indication For the short-term treatment of insomnia.
Mechanism of action Zolpidem modulates the alpha-subunit, known as the benzodiazepine receptor, within the GABAA receptor chloride channel macromolecular complex. Unlike the benzodiazepines, which non-selectively interact with all three alpha-receptor subtypes, Zolpidem preferentially binds to the alpha-1 receptor.
Absorption Zolpidem is rapidly absorbed from the GI tract.
Protein binding 92.5 ± 0.1% (independent of concentration between 40 and 790 ng/mL)
Biotransformation Zolpidem is converted to inactive metabolites in the liver.
Route of elimination Zolpidem tartrate tablets are converted to inactive metabolites that are eliminated primarily by renal excretion.
Toxicity Oral (male rat) LD50 = 695 mg/kg. Symptoms of overdose include impairment of consciousness ranging from somnolence to light coma.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amprenavir Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if amprenavir is initiated, discontinued or dose changed.
Atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if atazanavir is initiated, discontinued or dose changed.
Clarithromycin Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if clarithromycin is initiated, discontinued or dose changed.
Conivaptan Conivaptan, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if conivaptan is initiated, discontinued or dose changed.
Darunavir Darunavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if darunavir is initiated, discontinued or dose changed.
Delavirdine Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if delavirdine is initiated, discontinued or dose changed.
Dihydrocodeine Enhanced CNS depressant effects contraindicates concurrent use for certain brand name formulations of zolpidem.
Fluconazole Fluconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if fluconazole is initiated, discontinued or dose changed.
Fosamprenavir Fosamprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if fosamprenavir is initiated, discontinued or dose changed.
Indinavir Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if indinavir is initiated, discontinued or dose changed.
Isoniazid Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if isoniazid is initiated, discontinued or dose changed.
Itraconazole Itraconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if itraconazole is initiated, discontinued or dose changed.
Ketoconazole Ketoconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if ketoconazole is initiated, discontinued or dose changed.
Lopinavir Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if lopinavir is initiated, discontinued or dose changed.
Methotrimeprazine Additive CNS depressant effects. Reduce zolpidem dose by half upon initiation of methotrimeprazine. Zolpidem dose may be adjusted once methotrimeprazine dose has been established. Monitor for increased CNS depression.
Nefazodone Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if nefazodone is initiated, discontinued or dose changed.
Nelfinavir Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if nelfinavir is initiated, discontinued or dose changed.
Nicardipine Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if nicardipine is initiated, discontinued or dose changed.
Posaconazole Posaconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if posaconazole is initiated, discontinued or dose changed.
Quinidine Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if quinidine is initiated, discontinued or dose changed.
Ritonavir Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if ritonavir is initiated, discontinued or dose changed.
Saquinavir Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if saquinavir is initiated, discontinued or dose changed.
Telithromycin Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if telithromycin is initiated, discontinued or dose changed.
Triprolidine The CNS depressants, Triprolidine and Zolpidem, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Should not be administered with or immediately after a meal.
  • Avoid alcohol.

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions potentiator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Vlainic J, Pericic D: Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam. Neuropharmacology. 2009 Jun;56(8):1124-30. Epub 2009 Apr 1. - Pubmed
  • Smith AJ, Alder L, Silk J, Adkins C, Fletcher AE, Scales T, Kerby J, Marshall G, Wafford KA, McKernan RM, Atack JR: Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. Mol Pharmacol. 2001 May;59(5):1108-18. - Pubmed
  • Pritchett DB, Seeburg PH: Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem. 1990 May;54(5):1802-4. - Pubmed
DTHybrid score 0.4053
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action unknown
Actions agonist
References
  • Pritchett DB, Seeburg PH: Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem. 1990 May;54(5):1802-4. - Pubmed
  • Smith AJ, Alder L, Silk J, Adkins C, Fletcher AE, Scales T, Kerby J, Marshall G, Wafford KA, McKernan RM, Atack JR: Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. Mol Pharmacol. 2001 May;59(5):1108-18. - Pubmed
DTHybrid score 0.2993
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action unknown
Actions agonist
References
  • Pritchett DB, Seeburg PH: Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem. 1990 May;54(5):1802-4. - Pubmed
  • Smith AJ, Alder L, Silk J, Adkins C, Fletcher AE, Scales T, Kerby J, Marshall G, Wafford KA, McKernan RM, Atack JR: Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. Mol Pharmacol. 2001 May;59(5):1108-18. - Pubmed
DTHybrid score 0.2897

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.4385
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.3504
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
DTHybrid score 0.7997
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4835
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5785
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5051
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.5418
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4897

Predictions


Id Partner name Gene Name Score
4924 Cytochrome P450 2C8 CYP2C8 0.3122
1588 Multidrug resistance protein 1 ABCB1 0.2961
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.2725
6030 Cytochrome P450 2B6 CYP2B6 0.221
6013 Cytochrome P450 2E1 CYP2E1 0.2145
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.2031
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.2014
290 Prostaglandin G/H synthase 2 PTGS2 0.1824
6024 Cytochrome P450 1A1 CYP1A1 0.1447
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.1315
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.1314
5718 Cytochrome P450 2A6 CYP2A6 0.129
587 Serum albumin ALB 0.1284
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.1268
921 Glutamate receptor 2 GRIA2 0.1181
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.1152
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.1108
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.1105
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.1098
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.1058
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.1055
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.1052
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1051
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.1038
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1037
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.1035
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.1034
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0918
6106 Cytochrome P450 2C18 CYP2C18 0.0839
492 Histamine H1 receptor HRH1 0.0823
811 Translocator protein TSPO 0.0774
1729 Solute carrier family 22 member 6 SLC22A6 0.0738
824 Sodium-dependent serotonin transporter SLC6A4 0.0718
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0678
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.067
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0666
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0663
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0609
502 5-hydroxytryptamine 2A receptor HTR2A 0.0608
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0602
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0597
831 D(2) dopamine receptor DRD2 0.0595
862 Multidrug resistance-associated protein 1 ABCC1 0.0583
6145 Solute carrier family 22 member 1 SLC22A1 0.0571
556 Alpha-1A adrenergic receptor ADRA1A 0.0568
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0543
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0529
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0516
3811 Cytochrome P450 19A1 CYP19A1 0.0503
847 Mu-type opioid receptor OPRM1 0.0491
1898 Cytochrome P450 1B1 CYP1B1 0.0481
6144 Solute carrier family 22 member 2 SLC22A2 0.0478
318 Alpha-2A adrenergic receptor ADRA2A 0.047
320 5-hydroxytryptamine 1A receptor HTR1A 0.047
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0438
766 Beta-2 adrenergic receptor ADRB2 0.0425
6031 Cytochrome P450 3A43 CYP3A43 0.0424
23 D(1A) dopamine receptor DRD1 0.0421
713 Sodium-dependent dopamine transporter SLC6A3 0.0405
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0404
590 5-hydroxytryptamine 2C receptor HTR2C 0.0385
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0377
776 Bile salt export pump ABCB11 0.0375
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0375
467 Delta-type opioid receptor OPRD1 0.0364
731 HIV-1 protease HIV-1 protease 0.0363
341 5-hydroxytryptamine 3 receptor HTR3A 0.0357
118 Organic cation/carnitine transporter 2 SLC22A5 0.0354
6142 Solute carrier family 22 member 8 SLC22A8 0.0352
632 Alpha-1B adrenergic receptor ADRA1B 0.035
51 Muscarinic acetylcholine receptor M3 CHRM3 0.035
193 Beta-1 adrenergic receptor ADRB1 0.035
2164 Multidrug resistance-associated protein 4 ABCC4 0.0337
696 Kappa-type opioid receptor OPRK1 0.0337
6143 Solute carrier family 22 member 7 SLC22A7 0.0333
260 Cytochrome P450 51 ERG11 0.0329
761 Cytochrome P450 51 ERG11 0.0329
3163 Cytochrome P450 51 cyp51 0.0329
275 Arachidonate 5-lipoxygenase ALOX5 0.0323
871 Glucocorticoid receptor NR3C1 0.032
3941 Amine oxidase [flavin-containing] A MAOA 0.0315
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0311
638 D(3) dopamine receptor DRD3 0.031
817 DNA topoisomerase 2-alpha TOP2A 0.0302
885 5-hydroxytryptamine 1B receptor HTR1B 0.0294
136 Estrogen receptor ESR1 0.0282
238 Peroxisome proliferator-activated receptor gamma PPARG 0.028
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.028
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0279
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0274
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0272
629 Alpha-2B adrenergic receptor ADRA2B 0.027
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0267
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0266
468 Cytochrome P450 4A11 CYP4A11 0.0266
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0261
36 Insulin receptor INSR 0.0258
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0252
465 Calmodulin CALM1 0.0246
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0243
725 5-hydroxytryptamine 1D receptor HTR1D 0.0238
3939 Amine oxidase [flavin-containing] B MAOB 0.0235
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0233
482 Glycine receptor subunit alpha-1 GLRA1 0.0233
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0233
6182 Cytochrome P450 2J2 CYP2J2 0.0233
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0228
6147 Solute carrier family 22 member 3 SLC22A3 0.0226
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0224
3923 Cholinesterase BCHE 0.0221
789 Alpha-1D adrenergic receptor ADRA1D 0.022
378 Alpha-2C adrenergic receptor ADRA2C 0.0218
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0216
1757 Myeloperoxidase MPO 0.0216
705 Glutamate receptor 1 GRIA1 0.0212
432 D(4) dopamine receptor DRD4 0.0212
833 Organic cation/carnitine transporter 1 SLC22A4 0.0211
614 Progesterone receptor PGR 0.0203
477 DNA topoisomerase 4 subunit A parC 0.0201
886 DNA topoisomerase 4 subunit A parC 0.0201
6226 DNA topoisomerase 4 subunit A parC 0.0201
6148 Multidrug resistance-associated protein 7 ABCC10 0.02
404 DNA gyrase subunit A gyrA 0.0198
6224 DNA gyrase subunit A gyrA 0.0198
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0198
1024 Solute carrier family 22 member 11 SLC22A11 0.0197
6102 Arylamine N-acetyltransferase 2 NAT2 0.0195
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0194
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0194
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0194
70 Type-1 angiotensin II receptor AGTR1 0.0189
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0188
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0188
122 P2Y purinoceptor 12 P2RY12 0.0187
146 Androgen receptor AR 0.0186
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0183
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0182
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.018
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.018
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.018
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0177
891 Dihydropteroate synthase folP 0.0175
5359 Dihydropteroate synthase folP 0.0175
7175 Dihydropteroate synthase sulI 0.0175
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0173
777 Tumor necrosis factor TNF 0.0167
172 Potassium channel subfamily K member 1 KCNK1 0.0167
6220 Aryl hydrocarbon receptor AHR 0.0166
537 ATP synthase delta chain, mitochondrial ATP5D 0.0165
737 Mineralocorticoid receptor NR3C2 0.0163
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0162
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0161
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.016
4148 Serine/threonine-protein kinase mTOR MTOR 0.0159
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0158
504 Mast/stem cell growth factor receptor KIT 0.0156
232 Corticosteroid-binding globulin SERPINA6 0.0156
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0155
716 5-hydroxytryptamine 7 receptor HTR7 0.0153
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0152
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
436 5-hydroxytryptamine 2B receptor HTR2B 0.015
427 Substance-P receptor TACR1 0.0148
373 Transthyretin TTR 0.0146
94 5-hydroxytryptamine 4 receptor HTR4 0.0146
844 Epidermal growth factor receptor EGFR 0.0145
756 Sex hormone-binding globulin SHBG 0.0145
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0143
124 Histamine H2 receptor HRH2 0.014
818 50S ribosomal protein L10 rplJ 0.0139
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0136
163 D(1B) dopamine receptor DRD5 0.0135
407 Vascular endothelial growth factor receptor 2 KDR 0.0135
6020 Aldehyde oxidase AOX1 0.0134
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0134
380 Cytochrome P450 17A1 CYP17A1 0.0134
228 Beta platelet-derived growth factor receptor PDGFRB 0.0134
4604 Liver carboxylesterase 1 CES1 0.0133
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0132
6014 Cytochrome P450 2A13 CYP2A13 0.0132
26 Vascular endothelial growth factor receptor 3 FLT4 0.013
6137 Multidrug resistance-associated protein 6 ABCC6 0.0129
592 Carbonic anhydrase 4 CA4 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
32 Vascular endothelial growth factor receptor 1 FLT1 0.0124
1656 CYP2B protein CYP2B 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0121
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0121
1010 Cytochrome P450 51A1 CYP51A1 0.0121
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.012
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0118
6136 Multidrug resistance-associated protein 5 ABCC5 0.0118
1256 5-hydroxytryptamine 6 receptor HTR6 0.0117
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0117
738 Monocarboxylate transporter 1 SLC16A1 0.0117
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0116
16 Adenosine A1 receptor ADORA1 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
1507 Cytochrome c CYCS 0.0114
474 Acetylcholinesterase ACHE 0.0113
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0113
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0111
1178 Adenosine A2a receptor ADORA2A 0.011
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0108
528 5-hydroxytryptamine 1E receptor HTR1E 0.0108
161 Tubulin beta chain TUBB 0.0108
312 Tubulin beta chain TUB2 0.0108
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0108
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0107
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0106
3426 Glutamine synthetase glnA 0.0103
3987 Glutamine synthetase GLUL 0.0103
4120 NADPH--cytochrome P450 reductase POR 0.0102
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0102
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0101
6141 Sodium/bile acid cotransporter SLC10A1 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
723 Cytosolic phospholipase A2 PLA2G4A 0.01
3937 Fatty-acid amide hydrolase FAAH 0.0099
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0099
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0099
273 Apoptosis regulator Bcl-2 BCL2 0.0098
29 Tubulin beta-1 chain TUBB1 0.0098
295 Carbonic anhydrase 1 CA1 0.0097
49 Endothelin B receptor EDNRB 0.0096
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0096
3947 Xanthine dehydrogenase/oxidase XDH 0.0095
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0094
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0093
357 Carbonic anhydrase 2 CA2 0.0093
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0092
952 Dipeptidyl peptidase 4 DPP4 0.0092
578 Endothelin-1 receptor EDNRA 0.009
6085 Fatty acid-binding protein, intestinal FABP2 0.009
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0089
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0089
208 DNA-directed RNA polymerase beta' chain rpoC 0.0088
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0088
823 Fibroblast growth factor receptor 2 FGFR2 0.0087
4122 Histone deacetylase 2 HDAC2 0.0087
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0087
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0086
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0086
820 Glycine receptor subunit alpha-2 GLRA2 0.0086
3312 Fatty acid-binding protein, brain FABP7 0.0086
869 Estrogen receptor beta ESR2 0.0086
768 FK506-binding protein 1A FKBP1A 0.0083
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0082
365 Dihydrofolate reductase DHFR 0.0082
2381 Dihydrofolate reductase DFR1 0.0082
2833 Dihydrofolate reductase Not Available 0.0082
2931 Dihydrofolate reductase folA 0.0082
3544 Dihydrofolate reductase folA 0.0082
3682 Dihydrofolate reductase folA 0.0082
6642 Dihydrofolate reductase folA 0.0082
6756 Dihydrofolate reductase dfrA 0.0082
185 Vasopressin V1a receptor AVPR1A 0.0082
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0081
68 Cannabinoid receptor 1 CNR1 0.0081
6043 Putative G-protein coupled receptor 44 GPR44 0.0081
2539 Tubulin alpha-1 chain TUBA4A 0.0081
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
322 Vasopressin V2 receptor AVPR2 0.008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0079
183 Vascular endothelial growth factor A VEGFA 0.0079
173 Toll-like receptor 7 TLR7 0.0079
4237 50S ribosomal protein L22 rplV 0.0079
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0077
1629 Transcription factor AP-1 JUN 0.0077
1648 Elastin ELN 0.0076
1050 Bile salt sulfotransferase SULT2A1 0.0076
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0076
131 Synaptic vesicular amine transporter SLC18A2 0.0076
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0075
511 5-hydroxytryptamine 1F receptor HTR1F 0.0075
814 Ryanodine receptor 1 RYR1 0.0075
1618 High affinity nerve growth factor receptor NTRK1 0.0075
2981 Phospholipase A2, membrane associated PLA2G2A 0.0074
1517 Beta-3 adrenergic receptor ADRB3 0.0074
165 FL cytokine receptor FLT3 0.0073
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
130 Prostacyclin synthase PTGIS 0.0072
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0072
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0072
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0071
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0071
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0071
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0071
7 Nitric oxide synthase, inducible NOS2 0.0071
1502 Peroxisome proliferator-activated receptor delta PPARD 0.007
3601 Dihydropteroate synthase 1 folP1 0.007
3807 Dihydropteroate synthase 1 folP1 0.007
3808 Dihydropteroate synthase 2 folP2 0.007
33 Cystine/glutamate transporter SLC7A11 0.007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.007
2112 Toll-like receptor 9 TLR9 0.0069
6044 Serum paraoxonase/lactonase 3 PON3 0.0069
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0068
284 DNA-directed RNA polymerase beta chain rpoB 0.0068
5773 DNA-directed RNA polymerase beta chain rpoB 0.0068
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0068
634 Squalene monooxygenase SQLE 0.0067
7196 Squalene monooxygenase ERG1 0.0067
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0067
558 Solute carrier family 12 member 1 SLC12A1 0.0067
153 Dopamine beta-hydroxylase DBH 0.0067
4203 Histamine N-methyltransferase HNMT 0.0066
3810 Catechol O-methyltransferase COMT 0.0066
54 Prothrombin F2 0.0065
1196 Complement decay-accelerating factor CD55 0.0065
4238 50S ribosomal protein L4 rplD 0.0065
5578 50S ribosomal protein L4 rplD 0.0065
6173 50S ribosomal protein L4 rplD 0.0065
6219 50S ribosomal protein L4 rplD 0.0065
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0065
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0064
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0064
239 Coagulation factor X F10 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
133 Dihydropterate synthase sulI 0.0063
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0062
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
1192 Sulfotransferase 1A1 SULT1A1 0.0062
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0061
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.006
6126 Carbonic anhydrase 7 CA7 0.006
1275 Estrogen sulfotransferase SULT1E1 0.0059
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
469 Annexin A1 ANXA1 0.0059
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0059
4311 tRNA TRDMT1 0.0059
4325 tRNA trmD 0.0059
4328 tRNA trmD 0.0059
459 Retinoic acid receptor RXR-alpha RXRA 0.0059
1852 Microtubule-associated protein 2 MAP2 0.0059
174 Sigma 1-type opioid receptor SIGMAR1 0.0058
976 Platelet glycoprotein IX GP9 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
780 Retinoic acid receptor RXR-gamma RXRG 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
6432 Transporter snf 0.0057
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0056
2808 Chloramphenicol acetyltransferase 3 cat3 0.0056
703 NADPH azoreductase azr 0.0056
5300 Antigen peptide transporter 1 TAP1 0.0056
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0056
518 Peroxidase/catalase T katG 0.0055
6506 Stathmin-4 STMN4 0.0055
84 Nuclear receptor 0B1 NR0B1 0.0054
106 Cannabinoid receptor 2 CNR2 0.0054
6146 High affinity copper uptake protein 1 SLC31A1 0.0054
1864 RET proto-oncogene RET 0.0053
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0053
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0053
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0053
904 Glutathione S-transferase P GSTP1 0.0053
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
5923 Microtubule-associated protein tau MAPT 0.0053
5924 Microtubule-associated protein 4 MAP4 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
856 Vitamin D3 receptor VDR 0.0053
461 Glycine receptor subunit alpha-3 GLRA3 0.0053
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0052
319 Opioid receptor, sigma 1 OPRS1 0.0052
712 Tubulin alpha chain TUB1 0.0052
88 Retinoic acid receptor RXR-beta RXRB 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0052
2417 Chloramphenicol acetyltransferase cat 0.0052
3278 Chloramphenicol acetyltransferase cat 0.0052
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0051
2810 Dr hemagglutinin structural subunit draA 0.0051
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
1630 Integrin beta-2 ITGB2 0.005
4773 Deoxycytidine kinase DCK 0.005
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
4103 Proteasome subunit beta type 2 PSMB2 0.0049
4102 Proteasome subunit beta type 5 PSMB5 0.0049
4101 Proteasome subunit beta type 1 PSMB1 0.0049
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0049
563 Thyroid peroxidase TPO 0.0048
6103 Arylamine N-acetyltransferase 1 NAT1 0.0048
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
3086 Plasmepsin-2 Not Available 0.0046
6174 50S ribosomal protein L32 rpmF 0.0046
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0044
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0044
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0044
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0044
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0043
251 Alcohol dehydrogenase 1A ADH1A 0.0043
6149 Solute carrier family 22 member 10 SLC22A10 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
4192 DNA topoisomerase 2-beta TOP2B 0.0042
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0042
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0042
3932 Glutathione S-transferase A2 GSTA2 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
3913 Glutamic acid decarboxylase GAD65 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1374 Natriuretic peptides B NPPB 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1827 Gap junction alpha-1 protein GJA1 0.004
1908 Vascular cell adhesion protein 1 VCAM1 0.004
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.004
581 Cytochrome P450 2R1 CYP2R1 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
1541 Metalloproteinase mmp20 0.0039
4132 Chloride channel protein ClC-Ka CLCNKA 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
5934 Cytochrome P450 26A1 CYP26A1 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0038
444 Alcohol dehydrogenase 1B ADH1B 0.0038
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0038
85 Growth hormone receptor GHR 0.0038
572 Integrin alpha-L ITGAL 0.0037
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
2183 Fatty acid-binding protein, adipocyte FABP4 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
1714 Mitogen-activated protein kinase 3 MAPK3 0.0037
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0036
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
3856 Fibroblast growth factor receptor 3 FGFR3 0.0035
6048 Troponin C, skeletal muscle TNNC2 0.0035
164 Histamine H4 receptor HRH4 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
2207 Rhodopsin RHO 0.0035
939 50S ribosomal protein L3 rplC 0.0035
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0035
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
1039 Histone deacetylase 9 HDAC9 0.0035
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
3904 Alanine aminotransferase 2 GPT2 0.0034
735 Alanine aminotransferase 1 GPT 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0034
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0033
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0033
3809 Estrogen-related receptor gamma ESRRG 0.0033
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0033
908 Glutathione S-transferase theta-1 GSTT1 0.0033
3957 Adenosine deaminase ADA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
517 Alcohol dehydrogenase 1C ADH1C 0.0032
267 Plasminogen activator inhibitor 1 SERPINE1 0.0032
1650 Heme carrier protein 1 SLC46A1 0.0032
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0032
1770 Phospholipase C PLCL1 0.0032
2841 Phospholipase C plc 0.0032
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6131 Carbonic anhydrase 14 CA14 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
489 Monocarboxylate transporter 2 SLC16A7 0.0031
2236 Casein kinase II subunit alpha CSNK2A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
5787 Angiopoietin-1 receptor TEK 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.003
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
719 Retinoic acid receptor responder protein 1 RARRES1 0.003
770 Retinoic acid-induced protein 3 GPRC5A 0.003
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0029
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0029
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0029
936 Ephrin type-A receptor 2 EPHA2 0.0029
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0029
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0029
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0029
6221 Steroid hormone receptor ERR1 ESRRA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1992 Vitamin D-binding protein GC 0.0028
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0027
1268 Neuropeptide S receptor NPSR1 0.0027
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0027
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
162 Retinoic acid receptor gamma-1 RARG 0.0027
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
6500 Phospholipase A2 PLA2G1B 0.0026
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0026
569 Retinal dehydrogenase 2 ALDH1A2 0.0026
5880 Thrombopoietin receptor MPL 0.0025
6138 Multidrug resistance protein 3 ABCB4 0.0025
751 Potassium channel subfamily K member 6 KCNK6 0.0025
3830 Calreticulin CALR 0.0025
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
2021 Thrombomodulin THBD 0.0025
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
6073 Potassium channel subfamily K member 9 KCNK9 0.0024
6072 Potassium channel subfamily K member 3 KCNK3 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
3639 Thymidine phosphorylase deoA 0.0024
3936 Thymidine phosphorylase TYMP 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0023
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
65 Matrix metalloproteinase-9 Not Available 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
1341 Histamine H3 receptor HRH3 0.0023
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0023
822 Aldose reductase AKR1B1 0.0023
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
3404 Exotoxin A eta 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0021
1063 Signal transducer and activator of transcription 5B STAT5B 0.0021
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
268 Adenosine A2b receptor ADORA2B 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
1820 Beta-nerve growth factor NGF 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
1243 Cathepsin D CTSD 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6042 Prostaglandin reductase 2 PTGR2 0.0018
1253 Interferon gamma IFNG 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
291 Nitric-oxide synthase, endothelial NOS3 0.0017
1360 Sphingomyelin phosphodiesterase SMPD1 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
3233 Bile acid receptor NR1H4 0.0015
896 Glutathione S-transferase Mu 1 GSTM1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
5798 Mitogen-activated protein kinase 11 MAPK11 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0014
1313 Lactoylglutathione lyase GLO1 0.0014
4226 Uridine phosphorylase 2 UPP2 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6859 Protein S100-A4 S100A4 0.0014
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6218 Pannexin-1 PANX1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
4225 Uridine phosphorylase 1 UPP1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
413 Amidophosphoribosyltransferase PPAT 0.0012
2515 Amidophosphoribosyltransferase purF 0.0012
3714 Amidophosphoribosyltransferase purF 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
4948 Cytochrome c-553 Not Available 0.0011
4923 Cytochrome c3 DvMF_2499 0.0011
4945 Cytochrome c3 Not Available 0.0011
4949 Cytochrome c3 DVU_3171 0.0011
4968 Cytochrome c3 cytc3 0.0011
4997 Cytochrome c3 SO_2727 0.0011
5219 Cytochrome c3 cyd 0.0011
4902 Nine-heme cytochrome c Ddes_2038 0.0011
3189 High-molecular-weight cytochrome c hmcA 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2298 Cytochrome P450-cam camC 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
2132 Protein S100-B S100B 0.0009
1184 Interferon beta IFNB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
3221 Cytochrome c4 cc4 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4916 Cyanoglobin glbN 0.0006
4943 Cytochrome c6 petJ 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4984 Neuroglobin NGB 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4909 CooA protein cooA 0.0006
5000 HemO hemO 0.0006
4961 Hemophore HasA hasA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4910 Cytoglobin CYGB 0.0006
3116 Bacterioferritin bfr 0.0006
4906 Bacterioferritin bfr 0.0006
4965 Bacterioferritin bfr 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4972 P450cin cinA 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4952 Catalase/peroxidase katA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
798 Osteocalcin BGLAP 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
4920 Peroxidase/catalase katG 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
2119 Cytochrome b5 CYB5A 0.0005
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0005
4990 PpcA ppcA 0.0005
4037 Hypothetical protein GPX1 0.0005
4297 Hypothetical protein SP_1951 0.0005
4521 Hypothetical protein BC_2969 0.0005
4540 Hypothetical protein TM_1070 0.0005
4555 Hypothetical protein MT1739 0.0005
4569 Hypothetical protein mshD 0.0005
4578 Hypothetical protein PA3270 0.0005
4747 Hypothetical protein PA3967 0.0005
5177 Hypothetical protein TM_0096 0.0005
5194 Hypothetical protein PA1204 0.0005
5240 Hypothetical protein Rv2991 0.0005
5370 Hypothetical protein TM_1158 0.0005
5710 Hypothetical protein Tb927.5.1360 0.0005
4988 Sulfite oxidase, mitochondrial SUOX 0.0005
3570 Cytochrome P450 152A1 cypC 0.0005
369 Coagulation factor VII F7 0.0005
3375 Acidic cytochrome c3 Not Available 0.0005
2915 Sensor protein fixL fixL 0.0005
4944 Sensor protein fixL fixL 0.0005
4289 Cytochrome P450 TT_P0059 0.0005
6262 Cytochrome P450 staP 0.0005
4992 Cytochrome c peroxidase Not Available 0.0005
4385 Cytochrome c' Not Available 0.0005
4967 Cytochrome c' cycA 0.0005
5038 Cytochrome c' Not Available 0.0005
5223 Cytochrome c' cycP 0.0005
4813 Heme oxygenase hmuO 0.0005
5769 Heme oxygenase Not Available 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0004
2972 6-deoxyerythronolide B hydroxylase eryF 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
1439 Lactotransferrin LTF 0.0003
309 Antithrombin-III SERPINC1 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
358 Cystathionine beta-synthase CBS 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
693 Hemoglobin subunit beta HBB 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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