DT-Web

DB00908 - Quinidine


Identification
Name Quinidine
Accession Number DB00908 (APRD00136)
Type small molecule
Description An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 324.4168
Groups approved
Monoisotopic Weight 324.183778022
Pharmacology
Indication For the treatment of ventricular pre-excitation and cardiac dysrhythmias
Mechanism of action Quinidine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Quinidine may also act on the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito.
Absorption Not Available
Protein binding 80-88%
Biotransformation Not Available
Route of elimination When the urine pH is less than 7, about 20% of administered quinidine appears unchanged in the urine, but this fraction drops to as little as 5% when the urine is more alkaline.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Quinidine may increase the anticoagulant effect of acenocoumarol.
Alvimopan Decreases levels by P-glycoprotein (MDR-1) efflux transporter. Can significantly increase systemic exposure to P-glycoprotein substrates.
Amiloride Amiloride may decrease the therapeutic effect of quinidine. Monitor for changes in the therapeutic and adverse effects of quinidine if amiloride if initiated, discontinued or dose changed.
Amiodarone Amiodarone may increase the effect of quinidine.
Amitriptyline Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Amobarbital The anticonvulsant, amobarbital, decreases the effect of quinidine.
Anisindione Quinidine may increase the anticoagulant effect of anisindione.
Aprobarbital The anticonvulsant, aprobarbital, decreases the effect of quinidine.
Aripiprazole Quinidine increases the effect and toxicity of aripiprazole
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir Increased risk of cardiotoxicity and arrhythmias.
Atomoxetine The CYP2D6 inhibitor could increase the effect and toxicity of atomoxetine
Atracurium The quinine derivative increases the effect of the muscle relaxant
Bromazepam Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if quinidine is initiated, discontinued or dose changed. Dosage adjustments may be required.
Butabarbital The anticonvulsant, butabarbital, decreases the effect of quinidine.
Butalbital The anticonvulsant, butalbital, decreases the effect of quinidine.
Butethal The anticonvulsant, butethal, decreases the effect of quinidine.
Cimetidine Cimetidine may increase the serum concentration of quinidine. Monitor for changes in the therapeutic and adverse effects of quinidine if cimetidine is initiated, discontinued or dose changed.
Cisapride Increased risk of cardiotoxicity and arrhythmias
Clarithromycin Increased risk of cardiotoxicity and arrhythmias
Clomipramine Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Codeine Quinidine decreases the analgesic effect of codeine
Crizotinib Strong CYP3A4 inhibitors may increase levels of crizotinib. Consider alternative therapy.
Dabigatran etexilate Quinidine may increase the serum concentration of dabigatran etexilate, resulting in increased bleeding. Consider modification of therapy.
Dantrolene Quinidine may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if quinidine is initiated, discontinued or dose changed.
Desipramine Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Dextromethorphan Quinidine increases the toxicity of dextromethorphan
Dicumarol Quinidine may increase the anticoagulant effect of dicumarol.
Digitoxin Quinine/quinidine increases the effect of digoxin
Digoxin Quinine/quinidine increases the effect of digoxin
Dihydrocodeine Use of quinidine may reduce dihydrocodeine's analgesic effect.
Dihydroquinidine barbiturate The anticonvulsant, dihydroquinidine. barbiturate, decreases the effect of quinidine.
Diltiazem Diltiazem may increase the serum concentration of quinidine. Monitor for changes in the therapeutic and adverse effects of quinidine if diltiazem is initiated, discontinued or dose changed.
Donepezil Possible antagonism of action
Doxepin Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Erythromycin Increased risk of cardiotoxicity and arrhythmias
Etravirine Quinidine, when used concomitantly with etravirine, may experience a decrease in serum concentration. It is recommended to monitor quinidine therapy.
Fingolimod Pharmacodynamic synergist. Contraindicated. Increased risk of bradycardia, AV block, and torsade de pointes.
Fosphenytoin The anticonvulsant, fosphenytoin, decreases the effect of quinidine.
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Heptabarbital The anticonvulsant, heptabarbital, decreases the effect of quinidine.
Hexobarbital The anticonvulsant, hexobarbital, decreases the effect of quinidine.
Imipramine Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Itraconazole Itraconazole may increase the effect and toxicity of quinidine.
Ketoconazole Ketoconazole may increase the effect and toxicity of quinidine.
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Magnesium Magnesium antacids may decrease the absorption of quindine.
Magnesium salicylate The antacid increases the effect of quinidine
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Methohexital The anticonvulsant, methohexital, decreases the effect of quinidine.
Methylphenobarbital The anticonvulsant, methylphenobarbital, decreases the effect of quinidine.
Metocurine The quinine derivative increases the effect of the muscle relaxant
Moxifloxacin Increased risk of cardiotoxicity and arrhythmias
Nelfinavir Nelfinavir increases the effect and toxicity of quinidine
Nifedipine Decreased quinidine effect, increased nifedipine effect
Nortriptyline Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Ofloxacin Increased risk of cardiotoxicity and arrhythmias
Pancuronium The quinine derivative increases the effect of the muscle relaxant
Pentobarbital The anticonvulsant, pentobarbital, decreases the effect of quinidine.
Phenobarbital The anticonvulsant, phenobarbital, decreases the effect of quinidine.
Phenytoin The anticonvulsant, phenytoin, decreases the effect of quinidine.
Posaconazole Contraindicated co-administration
Primidone The anticonvulsant, primidone, decreases the effect of quinidine.
Procainamide Quinidine increases the effect of procainamide
Propafenone Quinidine increases the effect of propafenone
Protriptyline Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of protriptyline if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Quinidine barbiturate The anticonvulsant, quinidine. barbiturate, decreases the effect of quinidine.
Quinupristin This combination presents an increased risk of toxicity
Ranolazine Possible additive effect on QT prolongation
Rifampin Rifampin decreases the effect of quinidine
Ritonavir Ritonavir increases the effect and toxicity of quinidine
Rivastigmine Possible antagonism of action
Secobarbital The anticonvulsant, secobarbital, decreases the effect of quinidine.
Sodium bicarbonate The antacid increases the effect of quinidine
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Succinylcholine The quinine derivative increases the effect of the muscle relaxant
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution. Quinidine, a strong CYP3A4 inhibitor, may also increase the serum concentration of Tacrolimus by inhibiting its metabolism and clearance.
Tadalafil Quinidine may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Talbutal The anticonvulsant, talbutal, decreases the effect of quinidine.
Tamoxifen Quinidine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin Quinidine, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Quinidine is initiated, discontinued, or dose changed.
Telavancin Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Telithromycin Co-administration may result in altered plasma concentrations of Quinidine and/or Telithromycin. Consider alternate therapy or monitor for changes in the the therapeutic/adverse effects of both agents during concomitant therapy.
Temsirolimus Quinidine may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Quinidine, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Quinidine is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Tetrabenazine Strong CYP2D6 inhibitors may increase exposure of the metabolites of tetrabenazine. Consider a reduction of dose.
Thiopental Thiopental may increase the metabolism and clearance of Quinidine. Monitor for decreased therapeutic effect of Quinidine if Thiopental is initiated.
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Tiagabine The strong CYP3A4 inhibitor, Quinidine, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Quinidine is initiated, discontinued or dose changed.
Tipranavir Tipranavir, co-administered with Ritonavir, may increase the plasma concentration of Quinidine. Concomitant therapy is contraindicated.
Tolterodine Quinidine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Topotecan The p-glycoprotein inhibitor, Quinidine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol Quinidine may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Quinidine may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The CYP3A4 inhibitor, Quinidine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Quinidine is initiated, discontinued or dose changed.
Trimipramine Additive QTc-prolonging effects may occur, increasing the risk of serious cardiac arrhythmias. Quinidine, a CYP2D6/CYP3A4 inhibitor, may also inhibit the metabolism of Trimipramine, a CYP2D6/CYP3A4 substrate. Monitor for signs of cardiac arrhythmias and for changes in Trimipramine efficacy and toxicity if Quinidine is initiated, discontinued or dose changed.
Vardenafil Quinidine, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Vecuronium The quinine derivative increases the effect of the muscle relaxant
Venlafaxine Quinidine, a CYP2D6 and CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 and CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Quinidine is initiated, discontinued, or dose changed.
Verapamil Concurrent therapy may result in increased serum levels of both agents. Both agents are CYP3A4 inhibitors and substrates. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of the agent if the other is initiated, discontinued or dose changed.
Vilazodone CYP3A4 Inhibitors (Strong) may increase the serum concentration of Vilazodone. imit maximum adult vilazodone dose to 20 mg/day in patients receiving strong CYP3A4 inhibitors.
Vinblastine Quinidine, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Quinidine is initiated, discontinued or dose changed.
Vincristine Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Quinidine is initiated, discontinued or dose changed.
Vinorelbine Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Quinidine is initiated, discontinued or dose changed.
Voriconazole Voriconazole may increase the serum concentration of quinidine likely by inhibiting its metabolism by CYP3A4. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for changes in the serum concentration and toxic effects of quinidine if voriconazole is initiated, discontinued or dose changed.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Warfarin Quinidine may increase the anticoagulant effect of warfarin.
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zolpidem Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if quinidine is initiated, discontinued or dose changed.
Zonisamide Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if quinidine is initiated, discontinued or dose changed.
Zopiclone Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if quinidine is initiated, discontinued or dose changed.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP). Quinidine, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if quinidine is initiated, discontinued or dose changed.
Food Interactions
  • Preferably take on an ampty stomach.

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Stokoe KS, Thomas G, Goddard CA, Colledge WH, Grace AA, Huang CL: Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3. J Physiol. 2007 Jan 1;578(Pt 1):69-84. Epub 2006 Oct 5. - Pubmed
  • Itoh H, Shimizu M, Takata S, Mabuchi H, Imoto K: A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs. J Cardiovasc Electrophysiol. 2005 May;16(5):486-93. - Pubmed
  • Grant AO: Electrophysiological basis and genetics of Brugada syndrome. J Cardiovasc Electrophysiol. 2005 Sep;16 Suppl 1:S3-7. - Pubmed
  • Napolitano C, Priori SG: Brugada syndrome. Orphanet J Rare Dis. 2006 Sep 14;1:35. - Pubmed
  • Ohgo T, Okamura H, Noda T, Satomi K, Suyama K, Kurita T, Aihara N, Kamakura S, Ohe T, Shimizu W: Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation. Heart Rhythm. 2007 Jun;4(6):695-700. Epub 2007 Feb 20. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Sheets MF, Fozzard HA, Lipkind GM, Hanck DA: Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovasc Med. 2010 Jan;20(1):16-21. - Pubmed
  • Tella SR, Goldberg SR: Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12. - Pubmed
DTHybrid score 0.6425
Potassium channel subfamily K member 1
Name Potassium channel subfamily K member 1
Gene Name KCNK1
Pharmacological action unknown
Actions inhibitor
References
  • Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J: TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J. 1996 Mar 1;15(5):1004-11. - Pubmed
  • Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M: Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J. 1996 Dec 16;15(24):6854-62. - Pubmed
DTHybrid score 0.3306
Potassium channel subfamily K member 6
Name Potassium channel subfamily K member 6
Gene Name KCNK6
Pharmacological action unknown
Actions inhibitor
References
  • Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, Honore E: TWIK-2, an inactivating 2P domain K+ channel. J Biol Chem. 2000 Sep 15;275(37):28722-30. - Pubmed
  • Guerard NC, Traebert M, Suter W, Dumotier BM: Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart. J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):32-40. Epub 2008 Jun 8. - Pubmed
DTHybrid score 0.2324
Potassium voltage-gated channel subfamily H member 2
Name Potassium voltage-gated channel subfamily H member 2
Gene Name KCNH2
Pharmacological action unknown
Actions inhibitor
References
  • Po SS, Wang DW, Yang IC, Johnson JP Jr, Nie L, Bennett PB: Modulation of HERG potassium channels by extracellular magnesium and quinidine. J Cardiovasc Pharmacol. 1999 Feb;33(2):181-5. - Pubmed
  • Dong DL, Li Z, Wang HZ, Du ZM, Song WH, Yang BF: Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels. Basic Clin Pharmacol Toxicol. 2004 May;94(5):209-12. - Pubmed
  • Wolpert C, Schimpf R, Giustetto C, Antzelevitch C, Cordeiro J, Dumaine R, Brugada R, Hong K, Bauersfeld U, Gaita F, Borggrefe M: Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. - Pubmed
  • Lin C, Ke X, Cvetanovic I, Ranade V, Somberg J: The influence of extracellular acidosis on the effect of IKr blockers. J Cardiovasc Pharmacol Ther. 2005 Mar;10(1):67-76. - Pubmed
  • Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J: A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels. Am J Ther. 2005 Jul-Aug;12(4):328-36. - Pubmed
  • Guerard NC, Traebert M, Suter W, Dumotier BM: Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart. J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):32-40. Epub 2008 Jun 8. - Pubmed
DTHybrid score 0.3368

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Ludwig E, Schmid J, Beschke K, Ebner T: Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro. J Pharmacol Exp Ther. 1999 Jul;290(1):1-8. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score 1.1828
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.4682
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9295
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7837
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4622
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
  • van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. - Pubmed
DTHybrid score 0.4382
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5175
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6394
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7976

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed
  • Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
  • Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. - Pubmed
DTHybrid score 0.4006
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate,inhibitor
References
  • van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ: Comparison of - type I
  • Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
  • Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. - Pubmed
  • Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. - Pubmed
  • Zhang L, Gorset W, Dresser MJ, Giacomini KM: The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1. J Pharmacol Exp Ther. 1999 Mar;288(3):1192-8. - Pubmed
  • Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. - Pubmed
  • Sinclair CJ, Chi KD, Subramanian V, Ward KL, Green RM: Functional expression of a high affinity mammalian hepatic choline/organic cation transporter. J Lipid Res. 2000 Nov;41(11):1841-8. - Pubmed
  • Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. - Pubmed
  • Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. - Pubmed
  • Martel F, Vetter T, Russ H, Grundemann D, Azevedo I, Koepsell H, Schomig E: Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):320-6. - Pubmed
  • Busch AE, Quester S, Ulzheimer JC, Gorboulev V, Akhoundova A, Waldegger S, Lang F, Koepsell H: Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 1996 Oct 21;395(2-3):153-6. - Pubmed
  • Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. - Pubmed
DTHybrid score 0.4899
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
  • Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. - Pubmed
DTHybrid score 0.4223
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor
References
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed
DTHybrid score 0.2888
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. - Pubmed
  • Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. - Pubmed
  • Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. - Pubmed
  • Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. - Pubmed
  • Horie K, Tang F, Borchardt RT: Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res. 2003 Feb;20(2):161-8. - Pubmed
  • Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed
  • Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. - Pubmed
  • Tanigawara Y, Okamura N, Hirai M, Yasuhara M, Ueda K, Kioka N, Komano T, Hori R: Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther. 1992 Nov;263(2):840-5. - Pubmed
  • Ito T, Yano I, Tanaka K, Inui KI: Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997 Aug;282(2):955-60. - Pubmed
  • Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998 Jan 15;101(2):289-94. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
  • Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H: Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. Epub 2009 Jul 21. - Pubmed
  • Dahan A, Amidon GL: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. Epub 2009 Jun 18. - Pubmed
  • Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. Epub 2009 Mar 25. - Pubmed
  • Smith BJ, Doran AC, McLean S, Tingley FD 3rd, O'Neill BT, Kajiji SM: P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1252-9. - Pubmed
  • Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. - Pubmed
  • Neuhoff S, Ungell AL, Zamora I, Artursson P: pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm Res. 2003 Aug;20(8):1141-8. - Pubmed
  • Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. - Pubmed
  • Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
  • Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM: Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments] Circulation. 1999 Feb 2;99(4):552-7. - Pubmed
DTHybrid score 0.8543
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions inhibitor
References
  • van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ: Comparison of - type I
  • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
  • Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. - Pubmed
  • van Montfoort, J.E. et al. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther 291, 147-152 (1999). - Pubmed
DTHybrid score 0.3973
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions inhibitor
References
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
DTHybrid score 0.3543
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. - Pubmed
DTHybrid score 0.4137
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.3188
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions inhibitor
References
  • Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A: Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. J Pharm Pharmacol. 2003 Jul;55(7):1013-20. - Pubmed
DTHybrid score 0.3983

Carriers


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions
References Not Available
DTHybrid score 0.4006
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions
References Not Available
DTHybrid score 0.4899
Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions
References Not Available
DTHybrid score 0.4223
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions
References Not Available
DTHybrid score 0.2888
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.8543
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions
References Not Available
DTHybrid score 0.3973
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions
References Not Available
DTHybrid score 0.3543
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions
References Not Available
DTHybrid score 0.4137
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions
References Not Available
DTHybrid score 0.3188
Solute carrier organic anion transporter family member 1B1
Name Solute carrier organic anion transporter family member 1B1
Gene Name SLCO1B1
Actions
References Not Available
DTHybrid score 0.3983

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.6033
4118 Cytochrome P450 3A5 CYP3A5 0.5404
587 Serum albumin ALB 0.3011
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.2831
1729 Solute carrier family 22 member 6 SLC22A6 0.257
5718 Cytochrome P450 2A6 CYP2A6 0.2222
862 Multidrug resistance-associated protein 1 ABCC1 0.2118
6147 Solute carrier family 22 member 3 SLC22A3 0.1761
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1746
20 Prostaglandin G/H synthase 1 PTGS1 0.1612
492 Histamine H1 receptor HRH1 0.156
1024 Solute carrier family 22 member 11 SLC22A11 0.143
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.1392
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.1389
556 Alpha-1A adrenergic receptor ADRA1A 0.1363
6143 Solute carrier family 22 member 7 SLC22A7 0.1346
2164 Multidrug resistance-associated protein 4 ABCC4 0.1264
6106 Cytochrome P450 2C18 CYP2C18 0.1249
1898 Cytochrome P450 1B1 CYP1B1 0.1199
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1178
824 Sodium-dependent serotonin transporter SLC6A4 0.1174
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.1155
6141 Sodium/bile acid cotransporter SLC10A1 0.1151
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1094
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1085
540 Sodium-dependent noradrenaline transporter SLC6A2 0.1081
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.106
193 Beta-1 adrenergic receptor ADRB1 0.1059
502 5-hydroxytryptamine 2A receptor HTR2A 0.1054
831 D(2) dopamine receptor DRD2 0.1052
766 Beta-2 adrenergic receptor ADRB2 0.1049
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.1044
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.1032
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.1001
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0997
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0996
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0974
3811 Cytochrome P450 19A1 CYP19A1 0.0956
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0946
632 Alpha-1B adrenergic receptor ADRA1B 0.0945
290 Prostaglandin G/H synthase 2 PTGS2 0.0911
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0898
817 DNA topoisomerase 2-alpha TOP2A 0.0878
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0871
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0869
136 Estrogen receptor ESR1 0.0857
318 Alpha-2A adrenergic receptor ADRA2A 0.0821
789 Alpha-1D adrenergic receptor ADRA1D 0.0809
465 Calmodulin CALM1 0.0795
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0782
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.077
320 5-hydroxytryptamine 1A receptor HTR1A 0.0768
6148 Multidrug resistance-associated protein 7 ABCC10 0.0751
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0746
3923 Cholinesterase BCHE 0.0731
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0707
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0701
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0698
477 DNA topoisomerase 4 subunit A parC 0.0682
886 DNA topoisomerase 4 subunit A parC 0.0682
6226 DNA topoisomerase 4 subunit A parC 0.0682
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0681
23 D(1A) dopamine receptor DRD1 0.0675
404 DNA gyrase subunit A gyrA 0.0671
6224 DNA gyrase subunit A gyrA 0.0671
713 Sodium-dependent dopamine transporter SLC6A3 0.067
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.067
341 5-hydroxytryptamine 3 receptor HTR3A 0.0658
731 HIV-1 protease HIV-1 protease 0.0628
921 Glutamate receptor 2 GRIA2 0.0627
3941 Amine oxidase [flavin-containing] A MAOA 0.0623
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0622
847 Mu-type opioid receptor OPRM1 0.0601
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0585
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0585
468 Cytochrome P450 4A11 CYP4A11 0.0568
590 5-hydroxytryptamine 2C receptor HTR2C 0.0565
871 Glucocorticoid receptor NR3C1 0.0561
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0544
738 Monocarboxylate transporter 1 SLC16A1 0.0541
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0536
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.053
629 Alpha-2B adrenergic receptor ADRA2B 0.0522
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0516
3947 Xanthine dehydrogenase/oxidase XDH 0.0513
378 Alpha-2C adrenergic receptor ADRA2C 0.0509
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0502
6031 Cytochrome P450 3A43 CYP3A43 0.0495
6137 Multidrug resistance-associated protein 6 ABCC6 0.049
6136 Multidrug resistance-associated protein 5 ABCC5 0.049
3939 Amine oxidase [flavin-containing] B MAOB 0.0488
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0481
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0478
124 Histamine H2 receptor HRH2 0.047
33 Cystine/glutamate transporter SLC7A11 0.0461
260 Cytochrome P450 51 ERG11 0.046
761 Cytochrome P450 51 ERG11 0.046
3163 Cytochrome P450 51 cyp51 0.046
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0452
70 Type-1 angiotensin II receptor AGTR1 0.0452
696 Kappa-type opioid receptor OPRK1 0.0452
467 Delta-type opioid receptor OPRD1 0.045
4604 Liver carboxylesterase 1 CES1 0.0449
638 D(3) dopamine receptor DRD3 0.0443
885 5-hydroxytryptamine 1B receptor HTR1B 0.044
1757 Myeloperoxidase MPO 0.0436
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0427
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0421
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0411
380 Cytochrome P450 17A1 CYP17A1 0.0408
6182 Cytochrome P450 2J2 CYP2J2 0.0408
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0407
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0398
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0396
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.038
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0376
756 Sex hormone-binding globulin SHBG 0.0375
474 Acetylcholinesterase ACHE 0.0368
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0366
844 Epidermal growth factor receptor EGFR 0.0362
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0353
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0351
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0349
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0349
146 Androgen receptor AR 0.0349
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0348
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0347
737 Mineralocorticoid receptor NR3C2 0.0347
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0342
725 5-hydroxytryptamine 1D receptor HTR1D 0.0339
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0337
6014 Cytochrome P450 2A13 CYP2A13 0.0332
3587 Gastrotropin FABP6 0.0331
6220 Aryl hydrocarbon receptor AHR 0.0329
869 Estrogen receptor beta ESR2 0.0328
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0324
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0319
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0319
1517 Beta-3 adrenergic receptor ADRB3 0.0318
504 Mast/stem cell growth factor receptor KIT 0.0316
614 Progesterone receptor PGR 0.0315
131 Synaptic vesicular amine transporter SLC18A2 0.0312
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0307
6167 Organic solute transporter subunit beta OSTB 0.0305
6166 Organic solute transporter subunit alpha OSTA 0.0305
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0303
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0293
7 Nitric oxide synthase, inducible NOS2 0.0291
233 Potassium channel subfamily K member 2 KCNK2 0.0289
159 Penicillin-binding protein 2B penA 0.0289
6121 Penicillin-binding protein 2B penA 0.0289
122 P2Y purinoceptor 12 P2RY12 0.0289
904 Glutathione S-transferase P GSTP1 0.0284
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0283
777 Tumor necrosis factor TNF 0.0283
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.028
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0278
4120 NADPH--cytochrome P450 reductase POR 0.0277
161 Tubulin beta chain TUBB 0.0276
312 Tubulin beta chain TUB2 0.0276
432 D(4) dopamine receptor DRD4 0.0275
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0275
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.027
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.027
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0269
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0268
36 Insulin receptor INSR 0.0258
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0256
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.025
1010 Cytochrome P450 51A1 CYP51A1 0.0248
6010 Thiamine transporter 1 SLC19A2 0.0248
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0248
6020 Aldehyde oxidase AOX1 0.0246
2472 Voltage-gated potassium channel kcsA 0.0246
6366 Voltage-gated potassium channel kcsA 0.0246
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0244
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0242
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0242
373 Transthyretin TTR 0.0242
228 Beta platelet-derived growth factor receptor PDGFRB 0.0241
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0238
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0236
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0236
29 Tubulin beta-1 chain TUBB1 0.0234
94 5-hydroxytryptamine 4 receptor HTR4 0.0234
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0234
449 Ornithine decarboxylase ODC1 0.0233
407 Vascular endothelial growth factor receptor 2 KDR 0.0232
275 Arachidonate 5-lipoxygenase ALOX5 0.0232
26 Vascular endothelial growth factor receptor 3 FLT4 0.0227
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0226
436 5-hydroxytryptamine 2B receptor HTR2B 0.0226
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0224
976 Platelet glycoprotein IX GP9 0.0224
4203 Histamine N-methyltransferase HNMT 0.0224
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0223
175 Thiamin pyrophosphokinase 1 TPK1 0.0222
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0221
891 Dihydropteroate synthase folP 0.0221
5359 Dihydropteroate synthase folP 0.0221
7175 Dihydropteroate synthase sulI 0.0221
2449 Tubulin alpha-3 chain TUBA1A 0.022
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.022
16 Adenosine A1 receptor ADORA1 0.022
758 Thyroid hormone receptor alpha THRA 0.0219
2808 Chloramphenicol acetyltransferase 3 cat3 0.0218
32 Vascular endothelial growth factor receptor 1 FLT1 0.0217
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0214
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0211
811 Translocator protein TSPO 0.0211
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0211
3560 Gentamicin 3'-acetyltransferase aacC1 0.021
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.021
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.021
244 Angiotensin-converting enzyme ACE 0.0209
2429 Putrescine-binding periplasmic protein potF 0.0206
163 D(1B) dopamine receptor DRD5 0.0204
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0203
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0203
683 Potassium transporter GK0582 0.0203
1178 Adenosine A2a receptor ADORA2A 0.0202
1629 Transcription factor AP-1 JUN 0.0202
624 Guanidinoacetate N-methyltransferase GAMT 0.0201
6432 Transporter snf 0.02
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.02
6085 Fatty acid-binding protein, intestinal FABP2 0.0198
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0195
346 Thyroid hormone receptor beta-1 THRB 0.0195
594 Thyroxine-binding globulin SERPINA7 0.0195
6151 Monocarboxylate transporter 10 SLC16A10 0.0194
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0192
1256 5-hydroxytryptamine 6 receptor HTR6 0.0191
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.019
5126 Arginase rocF 0.0189
952 Dipeptidyl peptidase 4 DPP4 0.0189
4773 Deoxycytidine kinase DCK 0.0188
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0186
338 DNA polymerase UL30 0.0185
379 DNA polymerase UL54 0.0185
697 DNA polymerase ORF28 0.0185
2482 DNA polymerase 43 0.0185
4104 DNA polymerase BALF5 0.0185
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0185
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0185
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0185
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0185
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0184
482 Glycine receptor subunit alpha-1 GLRA1 0.0184
1192 Sulfotransferase 1A1 SULT1A1 0.0184
4122 Histone deacetylase 2 HDAC2 0.0184
6149 Solute carrier family 22 member 10 SLC22A10 0.0182
49 Endothelin B receptor EDNRB 0.0182
3270 Elongation factor G fusA 0.0181
4148 Serine/threonine-protein kinase mTOR MTOR 0.0181
3810 Catechol O-methyltransferase COMT 0.018
6146 High affinity copper uptake protein 1 SLC31A1 0.0179
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0179
613 Atrial natriuretic peptide receptor A NPR1 0.0179
6102 Arylamine N-acetyltransferase 2 NAT2 0.0178
183 Vascular endothelial growth factor A VEGFA 0.0178
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0175
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0175
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0175
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0175
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0175
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0174
716 5-hydroxytryptamine 7 receptor HTR7 0.0174
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0174
150 Cationic amino acid transporter 3 SLC7A3 0.0173
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0173
58 Cationic amino acid transporter 4 SLC7A4 0.0173
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0173
1656 CYP2B protein CYP2B 0.0172
578 Endothelin-1 receptor EDNRA 0.0172
5626 Nucleoside diphosphate kinase B NME2 0.0171
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0171
273 Apoptosis regulator Bcl-2 BCL2 0.017
908 Glutathione S-transferase theta-1 GSTT1 0.017
6168 Solute carrier family 22 member 16 SLC22A16 0.0169
633 Penicillin-binding proteins 1A/1B pbpA 0.0169
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0169
818 50S ribosomal protein L10 rplJ 0.0168
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0167
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0167
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0167
3086 Plasmepsin-2 Not Available 0.0165
645 Penicillin-binding protein 1A mrcA 0.0164
5805 Penicillin-binding protein 1A ponA 0.0164
6185 Penicillin-binding protein 1A mrcA 0.0164
6799 Penicillin-binding protein 1A pbpA 0.0164
1050 Bile salt sulfotransferase SULT2A1 0.0164
887 DNA gyrase subunit B gyrB 0.0162
4150 DNA gyrase subunit B gyrB 0.0162
6225 DNA gyrase subunit B gyrB 0.0162
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0162
365 Dihydrofolate reductase DHFR 0.0161
2381 Dihydrofolate reductase DFR1 0.0161
2833 Dihydrofolate reductase Not Available 0.0161
2931 Dihydrofolate reductase folA 0.0161
3544 Dihydrofolate reductase folA 0.0161
3682 Dihydrofolate reductase folA 0.0161
6642 Dihydrofolate reductase folA 0.0161
6756 Dihydrofolate reductase dfrA 0.0161
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0161
232 Corticosteroid-binding globulin SERPINA6 0.016
469 Annexin A1 ANXA1 0.0159
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0159
24 Thymidylate synthase TMP1 0.0157
359 Thymidylate synthase TYMS 0.0157
2626 Thymidylate synthase thyA 0.0157
2729 Thymidylate synthase thyA 0.0157
5352 Thymidylate synthase THYA 0.0157
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0156
2539 Tubulin alpha-1 chain TUBA4A 0.0156
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0154
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0154
672 Prostaglandin F2-alpha receptor PTGFR 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
3809 Estrogen-related receptor gamma ESRRG 0.0153
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0153
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0146
768 FK506-binding protein 1A FKBP1A 0.0146
84 Nuclear receptor 0B1 NR0B1 0.0145
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0144
2499 Tubulin beta-2C chain TUBB2C 0.0144
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0144
558 Solute carrier family 12 member 1 SLC12A1 0.0143
295 Carbonic anhydrase 1 CA1 0.0143
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0141
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0141
1618 High affinity nerve growth factor receptor NTRK1 0.0141
303 Diamine acetyltransferase 2 SAT2 0.0141
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0141
1317 Spermine synthase SMS 0.0141
623 Spermine oxidase SMOX 0.0141
3932 Glutathione S-transferase A2 GSTA2 0.014
164 Histamine H4 receptor HRH4 0.014
5880 Thrombopoietin receptor MPL 0.0139
5294 Nucleoside diphosphate kinase A NME1 0.0139
705 Glutamate receptor 1 GRIA1 0.0138
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0138
6165 Copper-transporting ATPase 1 ATP7A 0.0138
6163 Copper-transporting ATPase 2 ATP7B 0.0138
174 Sigma 1-type opioid receptor SIGMAR1 0.0138
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0137
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0137
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0136
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0136
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0136
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0136
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0136
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0136
537 ATP synthase delta chain, mitochondrial ATP5D 0.0136
511 5-hydroxytryptamine 1F receptor HTR1F 0.0135
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0135
165 FL cytokine receptor FLT3 0.0134
357 Carbonic anhydrase 2 CA2 0.0133
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0132
284 DNA-directed RNA polymerase beta chain rpoB 0.0132
5773 DNA-directed RNA polymerase beta chain rpoB 0.0132
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0132
427 Substance-P receptor TACR1 0.0131
185 Vasopressin V1a receptor AVPR1A 0.0131
1852 Microtubule-associated protein 2 MAP2 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
2300 Lysozyme E 0.013
3633 Lysozyme R 0.013
5597 Lysozyme 17 0.013
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.013
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0129
1630 Integrin beta-2 ITGB2 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
4192 DNA topoisomerase 2-beta TOP2B 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
828 Phenylalanine-4-hydroxylase PAH 0.0128
3109 Phenylalanine-4-hydroxylase phhA 0.0128
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0127
140 30S ribosomal protein S9 rpsI 0.0127
6719 30S ribosomal protein S9 rpsI 0.0127
6725 30S ribosomal protein S9 rpsI 0.0127
123 Diamine acetyltransferase 1 SAT1 0.0127
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0125
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0124
896 Glutathione S-transferase Mu 1 GSTM1 0.0124
4237 50S ribosomal protein L22 rplV 0.0123
1360 Sphingomyelin phosphodiesterase SMPD1 0.0123
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0122
6044 Serum paraoxonase/lactonase 3 PON3 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
6211 Tubulin epsilon chain TUBE1 0.0121
6210 Tubulin delta chain TUBD1 0.0121
6212 Tubulin gamma-1 chain TUBG1 0.0121
823 Fibroblast growth factor receptor 2 FGFR2 0.0121
571 Melatonin receptor type 1A MTNR1A 0.012
362 Melatonin receptor type 1B MTNR1B 0.012
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
291 Nitric-oxide synthase, endothelial NOS3 0.012
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.012
5787 Angiopoietin-1 receptor TEK 0.0119
551 Carnitine O-acetyltransferase CRAT 0.0119
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0118
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0117
1341 Histamine H3 receptor HRH3 0.0117
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0117
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0117
1374 Natriuretic peptides B NPPB 0.0117
1827 Gap junction alpha-1 protein GJA1 0.0116
1908 Vascular cell adhesion protein 1 VCAM1 0.0116
153 Dopamine beta-hydroxylase DBH 0.0116
48 Pyridoxal kinase PDXK 0.0116
1 Peptidoglycan synthetase ftsI ftsI 0.0115
4155 Peptidoglycan synthetase ftsI ftsI 0.0115
2016 Dipeptidase 1 DPEP1 0.0115
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0115
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0115
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0115
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0115
1353 DNA topoisomerase 1 TOP1 0.0114
3552 DNA topoisomerase 1 topA 0.0114
592 Carbonic anhydrase 4 CA4 0.0114
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0114
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0114
5923 Microtubule-associated protein tau MAPT 0.0114
5924 Microtubule-associated protein 4 MAP4 0.0114
4238 50S ribosomal protein L4 rplD 0.0114
5578 50S ribosomal protein L4 rplD 0.0114
6173 50S ribosomal protein L4 rplD 0.0114
6219 50S ribosomal protein L4 rplD 0.0114
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0113
543 Penicillin-binding protein 1B mrcB 0.0113
6186 Penicillin-binding protein 1B ponB 0.0113
6822 Penicillin-binding protein 1b pbp1b 0.0113
6844 Penicillin-binding protein 1b pbp1b 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
563 Thyroid peroxidase TPO 0.0113
6070 Nischarin NISCH 0.0113
221 Lysyl-tRNA synthetase KARS 0.0112
3856 Fibroblast growth factor receptor 3 FGFR3 0.0112
723 Cytosolic phospholipase A2 PLA2G4A 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
199 Monocarboxylate transporter 8 SLC16A2 0.0112
527 Prostacyclin receptor PTGIR 0.0111
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.011
22 30S ribosomal protein S4 rpsD 0.0109
6714 30S ribosomal protein S4 rpsD 0.0109
814 Ryanodine receptor 1 RYR1 0.0109
2112 Toll-like receptor 9 TLR9 0.0108
2443 Azurin azu 0.0108
5682 Ribonuclease pancreatic RNASE1 0.0108
6218 Pannexin-1 PANX1 0.0106
6043 Putative G-protein coupled receptor 44 GPR44 0.0106
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0106
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0106
6766 O-GlcNAcase BT_4395 BT_4395 0.0105
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0105
332 Beta-lactamase blaZ 0.0105
2478 Beta-lactamase ampC 0.0105
2613 Beta-lactamase ampC 0.0105
2635 Beta-lactamase ampC 0.0105
2700 Beta-lactamase penP 0.0105
5445 Beta-lactamase blaB 0.0105
6019 Beta-lactamase SHV-7 0.0105
6701 Beta-lactamase cphA 0.0105
6171 Solute carrier family 28 member 3 SLC28A3 0.0105
5934 Cytochrome P450 26A1 CYP26A1 0.0105
6138 Multidrug resistance protein 3 ABCB4 0.0105
1636 Trace amine-associated receptor 1 TAAR1 0.0104
517 Alcohol dehydrogenase 1C ADH1C 0.0104
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0104
528 5-hydroxytryptamine 1E receptor HTR1E 0.0102
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0102
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
1830 5'-nucleotidase NT5E 0.01
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.01
606 Cytochrome P450 27, mitochondrial CYP27A1 0.01
740 Argininosuccinate synthase ASS1 0.0099
865 Argininosuccinate synthase ASS1 0.0099
2680 Argininosuccinate synthase argG 0.0099
3194 Argininosuccinate synthase argG 0.0099
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0099
117 Sterol O-acyltransferase 1 SOAT1 0.0098
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
694 Matrix protein 2 M 0.0098
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0098
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0097
88 Retinoic acid receptor RXR-beta RXRB 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6126 Carbonic anhydrase 7 CA7 0.0096
3611 Cytidine deaminase cdd 0.0095
3707 Cytidine deaminase cdd 0.0095
4211 Cytidine deaminase CDA 0.0095
3917 Methylenetetrahydrofolate reductase MTHFR 0.0095
319 Opioid receptor, sigma 1 OPRS1 0.0094
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
267 Plasminogen activator inhibitor 1 SERPINE1 0.0092
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0091
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0091
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0091
769 High-affinity choline transporter 1 SLC5A7 0.0091
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0091
3926 Choline transporter-like protein 2 SLC44A2 0.0091
1686 Choline transporter-like protein 1 SLC44A1 0.0091
861 Choline kinase alpha CHKA 0.0091
3927 Choline transporter-like protein 3 SLC44A3 0.0091
700 Choline dehydrogenase, mitochondrial CHDH 0.0091
3925 Choline transporter-like protein 4 SLC44A4 0.0091
576 Choline O-acetyltransferase CHAT 0.0091
3922 Phospholipase D2 PLD2 0.0091
3924 Phospholipase D1 PLD1 0.0091
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0091
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.009
4228 Keratin, type II cytoskeletal 7 KRT7 0.009
1864 RET proto-oncogene RET 0.009
461 Glycine receptor subunit alpha-3 GLRA3 0.009
489 Monocarboxylate transporter 2 SLC16A7 0.0089
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0089
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0089
499 Arginine decarboxylase ADC 0.0089
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0089
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0089
6033 High affinity interleukin-8 receptor A CXCR1 0.0089
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0089
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
820 Glycine receptor subunit alpha-2 GLRA2 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
208 DNA-directed RNA polymerase beta' chain rpoC 0.0087
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0087
572 Integrin alpha-L ITGAL 0.0087
1714 Mitogen-activated protein kinase 3 MAPK3 0.0086
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0085
444 Alcohol dehydrogenase 1B ADH1B 0.0085
577 Argininosuccinate lyase ASL 0.0085
834 Arginase-2, mitochondrial ARG2 0.0084
251 Alcohol dehydrogenase 1A ADH1A 0.0084
4311 tRNA TRDMT1 0.0084
4325 tRNA trmD 0.0084
4328 tRNA trmD 0.0084
780 Retinoic acid receptor RXR-gamma RXRG 0.0083
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0083
6221 Steroid hormone receptor ERR1 ESRRA 0.0083
2981 Phospholipase A2, membrane associated PLA2G2A 0.0083
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0081
125 DNA polymerase beta POLB 0.0081
1650 Heme carrier protein 1 SLC46A1 0.0081
1275 Estrogen sulfotransferase SULT1E1 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
68 Cannabinoid receptor 1 CNR1 0.008
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.008
130 Prostacyclin synthase PTGIS 0.0079
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0079
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0079
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0079
173 Toll-like receptor 7 TLR7 0.0079
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0079
1770 Phospholipase C PLCL1 0.0079
2841 Phospholipase C plc 0.0079
518 Peroxidase/catalase T katG 0.0078
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0078
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0078
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0078
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0078
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0078
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0077
856 Vitamin D3 receptor VDR 0.0077
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0075
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0075
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0075
581 Cytochrome P450 2R1 CYP2R1 0.0075
4103 Proteasome subunit beta type 2 PSMB2 0.0074
4102 Proteasome subunit beta type 5 PSMB5 0.0074
4101 Proteasome subunit beta type 1 PSMB1 0.0074
1541 Metalloproteinase mmp20 0.0074
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0074
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0074
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0074
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0074
2391 Ferrochelatase hemH 0.0073
6502 Ferrochelatase DKFZp686P18130 0.0073
1591 Ferrochelatase, mitochondrial FECH 0.0073
162 Retinoic acid receptor gamma-1 RARG 0.0071
1760 Aminopeptidase N ANPEP 0.0071
6843 Aminopeptidase N pepN 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
1074 Urokinase-type plasminogen activator PLAU 0.0071
438 Taste receptor type 1 member 2 TAS1R2 0.0071
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.007
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.007
4217 Telomerase reverse transcriptase TERT 0.007
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0069
239 Coagulation factor X F10 0.0069
3426 Glutamine synthetase glnA 0.0069
3987 Glutamine synthetase GLUL 0.0069
702 UMP-CMP kinase CMPK1 0.0068
634 Squalene monooxygenase SQLE 0.0068
7196 Squalene monooxygenase ERG1 0.0068
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0068
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0066
1525 Heparin-binding growth factor 2 FGF2 0.0066
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0065
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0065
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0065
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0065
3686 Acyl-CoA thioesterase I precursor tesA 0.0065
1176 Mitogen-activated protein kinase 1 MAPK1 0.0065
1569 G1/S-specific cyclin-D1 CCND1 0.0064
860 Nicotinamide N-methyltransferase NNMT 0.0064
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0064
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0064
699 Nicotinic acid receptor 1 GPR109A 0.0064
928 Nicotinic acid receptor 2 GPR109B 0.0064
293 Gamma-glutamyl hydrolase GGH 0.0064
3937 Fatty-acid amide hydrolase FAAH 0.0064
6824 Tyrosine-protein kinase Lyn LYN 0.0064
3957 Adenosine deaminase ADA 0.0064
1820 Beta-nerve growth factor NGF 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0063
6493 Cytochrome c oxidase subunit 6C COX6C 0.0063
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0063
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0063
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0063
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0063
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0063
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0063
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0063
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0063
6559 Cytochrome c oxidase subunit 2 ctaC 0.0063
6669 Cytochrome c oxidase subunit 2 ctaC 0.0063
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0063
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0063
6558 Cytochrome c oxidase subunit 1 ctaD 0.0063
133 Dihydropterate synthase sulI 0.0063
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0063
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0062
1483 Membrane copper amine oxidase AOC3 0.0062
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0061
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0061
1992 Vitamin D-binding protein GC 0.0061
1291 cAMP response element-binding protein CREB1 0.0061
2216 Fibroblast growth factor receptor 4 FGFR4 0.006
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.006
859 Cellular retinoic acid-binding protein 2 CRABP2 0.006
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.006
54 Prothrombin F2 0.0059
569 Retinal dehydrogenase 2 ALDH1A2 0.0059
2232 Interleukin-5 IL5 0.0059
1593 Mucin-2 MUC2 0.0059
4210 Toll-like receptor 4 TLR4 0.0059
65 Matrix metalloproteinase-9 Not Available 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
2540 Choloylglycine hydrolase cbh 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
1039 Histone deacetylase 9 HDAC9 0.0057
788 Creatine kinase M-type CKM 0.0057
3808 Dihydropteroate synthase 2 folP2 0.0057
3601 Dihydropteroate synthase 1 folP1 0.0057
3807 Dihydropteroate synthase 1 folP1 0.0057
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0056
3830 Calreticulin CALR 0.0056
611 Retinal dehydrogenase 1 ALDH1A1 0.0055
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0055
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0055
6506 Stathmin-4 STMN4 0.0055
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0055
719 Retinoic acid receptor responder protein 1 RARRES1 0.0054
770 Retinoic acid-induced protein 3 GPRC5A 0.0054
5818 Folate receptor alpha FOLR1 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
6501 Fatty acid-binding protein, liver FABP1 0.0054
268 Adenosine A2b receptor ADORA2B 0.0054
2320 Thymidine kinase, cytosolic TK1 0.0054
106 Cannabinoid receptor 2 CNR2 0.0054
5353 Glutamate decarboxylase alpha gadA 0.0054
484 Tyrosine-protein kinase ABL2 ABL2 0.0054
663 Solute carrier family 12 member 4 SLC12A4 0.0053
53 Solute carrier family 12 member 5 SLC12A5 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
2021 Thrombomodulin THBD 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0052
1262 Corticotropin-lipotropin POMC 0.0052
936 Ephrin type-A receptor 2 EPHA2 0.0052
712 Tubulin alpha chain TUB1 0.0052
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0052
6034 Hydroxyindole O-methyltransferase ASMT 0.0052
6035 Nuclear receptor ROR-beta RORB 0.0052
6036 Eosinophil peroxidase EPX 0.0052
1196 Complement decay-accelerating factor CD55 0.0051
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0051
6131 Carbonic anhydrase 14 CA14 0.0051
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.005
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.005
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.005
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.005
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.005
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.005
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0049
6599 HTH-type transcriptional regulator ttgR ttgR 0.0049
310 Solute carrier family 12 member 2 SLC12A2 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
1123 Eosinophil cationic protein RNASE3 0.0049
3404 Exotoxin A eta 0.0049
2230 Catalase CAT 0.0048
3249 Catalase katA 0.0048
3625 Catalase katA 0.0048
4539 Catalase katA 0.0048
4941 Catalase katB 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
6122 Carbonic anhydrase 3 CA3 0.0048
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0048
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0048
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0048
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0048
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0047
1867 Major prion protein PRNP 0.0047
714 Glutathione reductase, mitochondrial GSR 0.0047
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0047
1405 Thiopurine S-methyltransferase TPMT 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
2236 Casein kinase II subunit alpha CSNK2A1 0.0046
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0046
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0046
3913 Glutamic acid decarboxylase GAD65 0.0045
6500 Phospholipase A2 PLA2G1B 0.0045
765 Indoleamine 2,3-dioxygenase IDO1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
6042 Prostaglandin reductase 2 PTGR2 0.0045
2599 Tyrosine-protein kinase HCK HCK 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
342 P protein [Includes: DNA-directed DNA polymerase P 0.0042
612 P protein [Includes: DNA-directed DNA polymerase P 0.0042
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
6174 50S ribosomal protein L32 rpmF 0.0042
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0041
229 Retinoic acid receptor beta RARB 0.0041
6209 30S ribosomal protein S19 rpsS 0.0041
6712 30S ribosomal protein S19 rpsS 0.0041
6726 30S ribosomal protein S19 rpsS 0.0041
6207 30S ribosomal protein S14 rpsN 0.0041
2417 Chloramphenicol acetyltransferase cat 0.0041
3278 Chloramphenicol acetyltransferase cat 0.0041
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0041
6048 Troponin C, skeletal muscle TNNC2 0.0041
760 Fibroblast growth factor 1 FGF1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
2810 Dr hemagglutinin structural subunit draA 0.004
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.004
500 Monocarboxylate transporter 4 SLC16A3 0.004
1313 Lactoylglutathione lyase GLO1 0.004
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
5482 Sialidase-2 NEU2 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
3685 Catabolite gene activator crp 0.0038
3904 Alanine aminotransferase 2 GPT2 0.0038
735 Alanine aminotransferase 1 GPT 0.0038
4655 Adenylate cyclase cyaC 0.0038
4759 Adenylate cyclase cyaB2 0.0038
3007 Carbonic anhydrase 12 CA12 0.0038
4205 Carbonic anhydrase 9 CA9 0.0038
400 Coagulation factor IX F9 0.0037
5461 Coagulation factor IX F9 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0037
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0037
1792 Tissue-type plasminogen activator PLAT 0.0036
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0036
6837 Serine/threonine-protein kinase 17B STK17B 0.0036
340 Apoptotic protease-activating factor 1 APAF1 0.0035
509 Thymidine kinase TK 0.0035
570 Thymidine kinase TK 0.0035
2559 Thymidine kinase TK 0.0035
3430 Thymidine kinase tdk 0.0035
3518 Thymidine kinase TK 0.0035
5301 Thymidine kinase tdk 0.0035
5771 Thymidine kinase ORF36 0.0035
7009 Thymidine kinase ORF36 0.0035
76 Nitric-oxide synthase, brain NOS1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0034
604 Vitamin K-dependent protein Z PROZ 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0034
1063 Signal transducer and activator of transcription 5B STAT5B 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
2207 Rhodopsin RHO 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
2249 Aspartate aminotransferase aspC 0.0033
2671 Aspartate aminotransferase aspC 0.0033
5490 Aspartate aminotransferase Not Available 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
4760 Mll3241 protein mll3241 0.0032
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
422 Vitamin K-dependent protein C PROC 0.0031
1245 Vitamin K-dependent protein S PROS1 0.0031
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0031
825 Arsenical pump-driving ATPase ASNA1 0.0031
3435 Arsenical pump-driving ATPase arsA 0.0031
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0031
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0031
154 AFG3-like protein 2 AFG3L2 0.0031
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0031
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0031
733 Activin receptor type 1B ACVR1B 0.0031
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0031
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0031
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0031
395 ALK tyrosine kinase receptor Not Available 0.0031
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
5798 Mitogen-activated protein kinase 11 MAPK11 0.0031
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0031
3639 Thymidine phosphorylase deoA 0.003
3936 Thymidine phosphorylase TYMP 0.003
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.003
1268 Neuropeptide S receptor NPSR1 0.003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.003
2298 Cytochrome P450-cam camC 0.003
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.003
1198 Serum paraoxonase/arylesterase 1 PON1 0.0029
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0029
6223 Penicillin-binding protein 1C pbpC 0.0029
292 Activin receptor type-1 ACVR1 0.0029
1507 Cytochrome c CYCS 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
6459 Glycodelin PAEP 0.0028
849 Activated CDC42 kinase 1 TNK2 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0027
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0027
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0027
297 Adenylate cyclase type 1 ADCY1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
6073 Potassium channel subfamily K member 9 KCNK9 0.0027
6072 Potassium channel subfamily K member 3 KCNK3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0027
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
867 Penicillin-binding protein 3 pbpC 0.0027
6119 Penicillin-binding protein 3 pbp3 0.0027
7154 Penicillin-binding protein 3 pbp3 0.0027
7157 Penicillin-binding protein 3 LMHCC_2184 0.0027
7162 Penicillin-binding protein 3 pbpB 0.0027
7172 Penicillin-binding protein 3 pbp3 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
358 Cystathionine beta-synthase CBS 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
1654 Interleukin-1 beta IL1B 0.0026
2408 Tyrosine-protein kinase SYK SYK 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
6135 Sodium channel subunit beta-4 SCN4B 0.0026
6134 Sodium channel subunit beta-3 SCN3B 0.0026
6132 Sodium channel subunit beta-1 SCN1B 0.0026
6127 Carbonic anhydrase-related protein CA8 0.0026
6133 Sodium channel subunit beta-2 SCN2B 0.0026
6128 Carbonic anhydrase-related protein 10 CA10 0.0026
6129 Carbonic anhydrase-related protein 11 CA11 0.0026
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0026
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
6859 Protein S100-A4 S100A4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
798 Osteocalcin BGLAP 0.0025
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0023
4226 Uridine phosphorylase 2 UPP2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
369 Coagulation factor VII F7 0.0023
822 Aldose reductase AKR1B1 0.0023
661 ADP/ATP translocase 1 SLC25A4 0.0023
6021 Adenosine kinase ADK 0.0023
3221 Cytochrome c4 cc4 0.0023
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0022
6130 Carbonic anhydrase 13 CA13 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
494 Caspase-1 CASP1 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
4225 Uridine phosphorylase 1 UPP1 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
413 Amidophosphoribosyltransferase PPAT 0.002
2515 Amidophosphoribosyltransferase purF 0.002
3714 Amidophosphoribosyltransferase purF 0.002
1970 Protein kinase C alpha type PRKCA 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
3760 Penicillin-binding protein 5 precursor dacA 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
2077 Caspase-3 CASP3 0.0018
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
819 Penicillin-binding protein 4 dacB 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
4041 Microsomal glutathione S-transferase 2 MGST2 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
6677 Myelin P2 protein PMP2 0.0015
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6645 D-amino-acid oxidase DAO 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
4031 Glutathione S-transferase A1 GSTA1 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
85 Growth hormone receptor GHR 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
2802 Endoglucanase G celCCG 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
345 Plasma retinol-binding protein RBP4 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0007
4034 Glutaredoxin-1 GLRX 0.0007
910 Epididymal secretory glutathione peroxidase GPX5 0.0007
903 Glutathione S-transferase A5 GSTA5 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
1928 Leukotriene C4 synthase LTC4S 0.0007
4029 Microsomal glutathione S-transferase 3 MGST3 0.0007
4032 Microsomal glutathione S-transferase 1 MGST1 0.0007
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0007
4040 Glutathione peroxidase 7 GPX7 0.0007
907 Glutathione peroxidase 2 GPX2 0.0007
4038 Glutathione peroxidase 4 GPX4 0.0007
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0007
906 Glutathione peroxidase 1 GPX1 0.0007
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0007
4035 Glutathione S-transferase Mu 5 GSTM5 0.0007
4036 Glutathione peroxidase 6 GPX6 0.0007
900 Glutathione S-transferase A4 GSTA4 0.0007
911 Glutathione peroxidase 3 GPX3 0.0007
4042 Glutathione transferase omega-2 GSTO2 0.0007
4033 S-formylglutathione hydrolase ESD 0.0007
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
3319 Hydroxyacylglutathione hydrolase HAGH 0.0007
898 Glutathione S-transferase A3 GSTA3 0.0007
897 Glutathione S-transferase kappa 1 GSTK1 0.0007
909 Maleylacetoacetate isomerase GSTZ1 0.0007
899 Glutathione S-transferase Mu 3 GSTM3 0.0006
905 Glutathione transferase omega-1 GSTO1 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
2165 Glutathione S-transferase Mu 2 GSTM2 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
207 Glutathione synthetase GSS 0.0006
5269 Glutathione synthetase gshB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
901 Glutathione S-transferase Mu 4 GSTM4 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
693 Hemoglobin subunit beta HBB 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
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