DT-Web

DB01198 - Zopiclone


Identification
Name Zopiclone
Accession Number DB01198 (APRD00356)
Type small molecule
Description Zopiclone is a novel hypnotic agent used in the treatment of insomnia. Its mechanism of action is based on modulating benzodiazepine receptors. In addition to zopiclone's benzodiazepine pharmacological properties it also has some barbiturate like properties.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 388.808
Groups approved
Monoisotopic Weight 388.105066147
Pharmacology
Indication For the short-term treatment of insomnia.
Mechanism of action Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. Both zopiclone and benzodiazepines act indiscriminately at the benzodiazepine binding site on ?1, ?2, ?3 and ?5 GABAA containing receptors as full agonists causing an enhancement of the inhibitory actions of GABA to produce the therapeutic (hypnotic and anxiolytic) and adverse effects of zopiclone.
Absorption Rapidly absorbed following oral administration.
Protein binding Approximately 45%
Biotransformation Extensively metabolized in the liver via decarboxylation (major pathway), demethylation, and side chain oxidation. Metabolites include an N-oxide derivative (weakly active; approximately 12% of a dose) and an N-desmethyl metabolite (inactive; approximately 16%). Approximately 50% of a dose is converted to other inactive metabolites via decarboxylation. Hepatic microsomal enzymes are apparently not involved in zopiclone clearance.
Route of elimination Not Available
Toxicity Rare individual instances of fatal outcomes following overdose with racemic zopiclone have been reported in European postmarketing reports, most often associated with overdose with other CNS-depressant agent. Signs and symptoms of overdose effects of CNS depressants can be expected to present as exaggerations of the pharmacological effects noted in preclinical testing.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amprenavir Amprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if amprenavir is initiated, discontinued or dose changed.
Atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if atazanavir is initiated, discontinued or dose changed.
Clarithromycin Clarithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if clarithromycin is initiated, discontinued or dose changed.
Conivaptan Conivaptan, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if conivaptan is initiated, discontinued or dose changed.
Darunavir Darunavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if darunavir is initiated, discontinued or dose changed.
Delavirdine Delavirdine, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if delavirdine is initiated, discontinued or dose changed.
Erythromycin The macrolide antibiotic, erythromycin, may increase the serum concentration of zopiclone. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if erythromycin is initiated, discontinued or dose changed.
Fosamprenavir Fosamprenavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if fosamprenavir is initiated, discontinued or dose changed.
Imatinib Imatinib, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if imatinib is initiated, discontinued or dose changed.
Indinavir Indinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if indinavir is initiated, discontinued or dose changed.
Isoniazid Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if isoniazid is initiated, discontinued or dose changed.
Itraconazole Itraconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if itraconzole is initiated, discontinued or dose changed.
Ketoconazole Ketonconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if ketoconazole is initiated, discontinued or dose changed.
Lopinavir Lopinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if lopinavir is initiated, discontinued or dose changed.
Methotrimeprazine Additive CNS depressant effects. Reduce zopiclone dose by half upon initiation of methotrimeprazine. Zopiclone dose may be adjusted once methotrimeprazine dose has been established. Monitor for increased CNS depression.
Nefazodone Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if nefazodone is initiated, discontinued or dose changed.
Nelfinavir Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if nelfinavir is initiated, discontinued or dose changed.
Nicardipine Nicardipine, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if nicardipine is initiated, discontinued or dose changed.
Posaconazole Posaconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if posaconazole is initiated, discontinued or dose changed.
Quinidine Quinidine, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if quinidine is initiated, discontinued or dose changed.
Ritonavir Ritonavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if ritonavir is initiated, discontinued or dose changed.
Saquinavir Saquinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if saquinavir is initiated, discontinued or dose changed.
Telithromycin Telithromycin, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if telithromycin is initiated, discontinued or dose changed.
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Zopiclone. Consider alternate therapy or monitor for changes in Zopiclone therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Triprolidine The CNS depressants, Triprolidine and Zopiclone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Gamma-aminobutyric-acid receptor subunit alpha-1
Name Gamma-aminobutyric-acid receptor subunit alpha-1
Gene Name GABRA1
Pharmacological action yes
Actions potentiator
References
  • Nutt DJ, Stahl SM: Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics. J Psychopharmacol. 2009 Nov 26. - Pubmed
  • Hanson SM, Morlock EV, Satyshur KA, Czajkowski C: Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different. J Med Chem. 2008 Nov 27;51(22):7243-52. - Pubmed
  • Sanger DJ: The pharmacology and mechanisms of action of new generation, non-benzodiazepine hypnotic agents. CNS Drugs. 2004;18 Suppl 1:9-15; discussion 41, 43-5. - Pubmed
  • Skerritt JH, Johnston GA: Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 1983 May 6;89(3-4):193-8. - Pubmed
  • Ramerstorfer J, Furtmuller R, Vogel E, Huck S, Sieghart W: The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. Eur J Pharmacol. 2010 Jun 25;636(1-3):18-27. Epub 2010 Mar 19. - Pubmed
DTHybrid score 0.5343
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action yes
Actions potentiator
References
  • Nutt DJ, Stahl SM: Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics. J Psychopharmacol. 2009 Nov 26. - Pubmed
  • Hanson SM, Morlock EV, Satyshur KA, Czajkowski C: Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different. J Med Chem. 2008 Nov 27;51(22):7243-52. - Pubmed
  • Ramerstorfer J, Furtmuller R, Vogel E, Huck S, Sieghart W: The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. Eur J Pharmacol. 2010 Jun 25;636(1-3):18-27. Epub 2010 Mar 19. - Pubmed
DTHybrid score 0.4246
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action yes
Actions potentiator
References
  • Nutt DJ, Stahl SM: Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics. J Psychopharmacol. 2009 Nov 26. - Pubmed
  • Hanson SM, Morlock EV, Satyshur KA, Czajkowski C: Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different. J Med Chem. 2008 Nov 27;51(22):7243-52. - Pubmed
  • Ramerstorfer J, Furtmuller R, Vogel E, Huck S, Sieghart W: The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. Eur J Pharmacol. 2010 Jun 25;636(1-3):18-27. Epub 2010 Mar 19. - Pubmed
DTHybrid score 0.4157
Gamma-aminobutyric-acid receptor subunit alpha-5
Name Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name GABRA5
Pharmacological action yes
Actions potentiator
References
  • Nutt DJ, Stahl SM: Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics. J Psychopharmacol. 2009 Nov 26. - Pubmed
  • Hanson SM, Morlock EV, Satyshur KA, Czajkowski C: Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different. J Med Chem. 2008 Nov 27;51(22):7243-52. - Pubmed
  • Skerritt JH, Johnston GA: Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol. 1983 May 6;89(3-4):193-8. - Pubmed
  • Ramerstorfer J, Furtmuller R, Vogel E, Huck S, Sieghart W: The point mutation gamma 2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes. Eur J Pharmacol. 2010 Jun 25;636(1-3):18-27. Epub 2010 Mar 19. - Pubmed
DTHybrid score 0.4243
Translocator protein
Name Translocator protein
Gene Name TSPO
Pharmacological action unknown
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3204

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lalovic B, Phillips B, Risler LL, Howald W, Shen DD: Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54. - Pubmed
DTHybrid score 0.5849
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lalovic B, Phillips B, Risler LL, Howald W, Shen DD: Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54. - Pubmed
DTHybrid score 0.3425
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4871
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4931
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.317

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.2944
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.2939
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.2881
4119 Cytochrome P450 2D6 CYP2D6 0.2218
4200 Cytochrome P450 1A2 CYP1A2 0.2179
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.1829
290 Prostaglandin G/H synthase 2 PTGS2 0.1793
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.1766
1588 Multidrug resistance protein 1 ABCB1 0.1748
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.1745
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.1744
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.1727
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.172
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1718
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.1692
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.1682
4118 Cytochrome P450 3A5 CYP3A5 0.1673
6030 Cytochrome P450 2B6 CYP2B6 0.1669
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.1643
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.1617
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.1613
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1611
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.1609
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.1607
921 Glutamate receptor 2 GRIA2 0.1543
6107 Cytochrome P450 3A7 CYP3A7 0.1325
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.1142
5718 Cytochrome P450 2A6 CYP2A6 0.1107
587 Serum albumin ALB 0.1088
6024 Cytochrome P450 1A1 CYP1A1 0.0852
6106 Cytochrome P450 2C18 CYP2C18 0.0627
1729 Solute carrier family 22 member 6 SLC22A6 0.0584
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0528
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0459
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0448
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0446
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0419
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0409
3811 Cytochrome P450 19A1 CYP19A1 0.0395
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0383
492 Histamine H1 receptor HRH1 0.0359
862 Multidrug resistance-associated protein 1 ABCC1 0.0342
1181 Alpha-1-acid glycoprotein 1 ORM1 0.034
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0336
275 Arachidonate 5-lipoxygenase ALOX5 0.0316
1898 Cytochrome P450 1B1 CYP1B1 0.0311
2164 Multidrug resistance-associated protein 4 ABCC4 0.0294
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0293
824 Sodium-dependent serotonin transporter SLC6A4 0.029
6102 Arylamine N-acetyltransferase 2 NAT2 0.0275
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0275
482 Glycine receptor subunit alpha-1 GLRA1 0.0273
6142 Solute carrier family 22 member 8 SLC22A8 0.0271
136 Estrogen receptor ESR1 0.0262
502 5-hydroxytryptamine 2A receptor HTR2A 0.0261
556 Alpha-1A adrenergic receptor ADRA1A 0.0249
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0247
776 Bile salt export pump ABCB11 0.0246
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0245
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0239
260 Cytochrome P450 51 ERG11 0.0236
761 Cytochrome P450 51 ERG11 0.0236
3163 Cytochrome P450 51 cyp51 0.0236
6145 Solute carrier family 22 member 1 SLC22A1 0.023
6020 Aldehyde oxidase AOX1 0.0229
831 D(2) dopamine receptor DRD2 0.0226
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.022
871 Glucocorticoid receptor NR3C1 0.0219
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0219
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0215
6144 Solute carrier family 22 member 2 SLC22A2 0.0214
705 Glutamate receptor 1 GRIA1 0.0213
6031 Cytochrome P450 3A43 CYP3A43 0.0211
468 Cytochrome P450 4A11 CYP4A11 0.021
537 ATP synthase delta chain, mitochondrial ATP5D 0.0209
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0204
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0202
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0198
318 Alpha-2A adrenergic receptor ADRA2A 0.0198
1024 Solute carrier family 22 member 11 SLC22A11 0.0196
6143 Solute carrier family 22 member 7 SLC22A7 0.0193
23 D(1A) dopamine receptor DRD1 0.0191
891 Dihydropteroate synthase folP 0.019
5359 Dihydropteroate synthase folP 0.019
7175 Dihydropteroate synthase sulI 0.019
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0187
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0186
847 Mu-type opioid receptor OPRM1 0.0186
1757 Myeloperoxidase MPO 0.0185
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0179
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0174
70 Type-1 angiotensin II receptor AGTR1 0.0174
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0172
731 HIV-1 protease HIV-1 protease 0.0171
467 Delta-type opioid receptor OPRD1 0.017
341 5-hydroxytryptamine 3 receptor HTR3A 0.0169
172 Potassium channel subfamily K member 1 KCNK1 0.0164
696 Kappa-type opioid receptor OPRK1 0.0159
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0158
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0155
320 5-hydroxytryptamine 1A receptor HTR1A 0.0151
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0151
465 Calmodulin CALM1 0.015
122 P2Y purinoceptor 12 P2RY12 0.0148
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0147
590 5-hydroxytryptamine 2C receptor HTR2C 0.0146
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0144
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0143
118 Organic cation/carnitine transporter 2 SLC22A5 0.0142
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.014
3937 Fatty-acid amide hydrolase FAAH 0.014
3941 Amine oxidase [flavin-containing] A MAOA 0.0139
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0136
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0136
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0135
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0133
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0132
4116 Dihydropteroate synthetase Not Available 0.0131
632 Alpha-1B adrenergic receptor ADRA1B 0.013
373 Transthyretin TTR 0.0128
3923 Cholinesterase BCHE 0.0127
146 Androgen receptor AR 0.0127
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0123
713 Sodium-dependent dopamine transporter SLC6A3 0.0122
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.012
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0119
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0119
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0118
592 Carbonic anhydrase 4 CA4 0.0117
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0116
777 Tumor necrosis factor TNF 0.0115
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0115
1507 Cytochrome c CYCS 0.0115
6147 Solute carrier family 22 member 3 SLC22A3 0.0113
766 Beta-2 adrenergic receptor ADRB2 0.0113
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0108
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0108
3939 Amine oxidase [flavin-containing] B MAOB 0.0107
6182 Cytochrome P450 2J2 CYP2J2 0.0106
16 Adenosine A1 receptor ADORA1 0.0106
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0105
789 Alpha-1D adrenergic receptor ADRA1D 0.0103
885 5-hydroxytryptamine 1B receptor HTR1B 0.0103
629 Alpha-2B adrenergic receptor ADRA2B 0.0102
4604 Liver carboxylesterase 1 CES1 0.01
817 DNA topoisomerase 2-alpha TOP2A 0.01
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0099
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0099
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0099
2183 Fatty acid-binding protein, adipocyte FABP4 0.0098
6141 Sodium/bile acid cotransporter SLC10A1 0.0098
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0098
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0098
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0097
6085 Fatty acid-binding protein, intestinal FABP2 0.0097
614 Progesterone receptor PGR 0.0096
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0096
29 Tubulin beta-1 chain TUBB1 0.0096
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0095
833 Organic cation/carnitine transporter 1 SLC22A4 0.0093
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0093
365 Dihydrofolate reductase DHFR 0.0092
2381 Dihydrofolate reductase DFR1 0.0092
2833 Dihydrofolate reductase Not Available 0.0092
2931 Dihydrofolate reductase folA 0.0092
3544 Dihydrofolate reductase folA 0.0092
3682 Dihydrofolate reductase folA 0.0092
6642 Dihydrofolate reductase folA 0.0092
6756 Dihydrofolate reductase dfrA 0.0092
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0092
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0091
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0091
3426 Glutamine synthetase glnA 0.009
3987 Glutamine synthetase GLUL 0.009
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.009
6137 Multidrug resistance-associated protein 6 ABCC6 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
638 D(3) dopamine receptor DRD3 0.0088
738 Monocarboxylate transporter 1 SLC16A1 0.0088
6014 Cytochrome P450 2A13 CYP2A13 0.0088
6136 Multidrug resistance-associated protein 5 ABCC5 0.0088
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0088
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0087
6148 Multidrug resistance-associated protein 7 ABCC10 0.0087
295 Carbonic anhydrase 1 CA1 0.0086
357 Carbonic anhydrase 2 CA2 0.0086
3810 Catechol O-methyltransferase COMT 0.0086
3312 Fatty acid-binding protein, brain FABP7 0.0086
725 5-hydroxytryptamine 1D receptor HTR1D 0.0086
1010 Cytochrome P450 51A1 CYP51A1 0.0085
94 5-hydroxytryptamine 4 receptor HTR4 0.0084
820 Glycine receptor subunit alpha-2 GLRA2 0.0084
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0083
1178 Adenosine A2a receptor ADORA2A 0.0083
504 Mast/stem cell growth factor receptor KIT 0.0083
869 Estrogen receptor beta ESR2 0.0082
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
185 Vasopressin V1a receptor AVPR1A 0.0082
427 Substance-P receptor TACR1 0.0082
1648 Elastin ELN 0.0081
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0081
232 Corticosteroid-binding globulin SERPINA6 0.008
322 Vasopressin V2 receptor AVPR2 0.008
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0079
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0078
436 5-hydroxytryptamine 2B receptor HTR2B 0.0075
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0075
1541 Metalloproteinase mmp20 0.0074
613 Atrial natriuretic peptide receptor A NPR1 0.0074
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0074
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0074
2981 Phospholipase A2, membrane associated PLA2G2A 0.0073
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0073
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0073
6220 Aryl hydrocarbon receptor AHR 0.0073
130 Prostacyclin synthase PTGIS 0.0072
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0071
380 Cytochrome P450 17A1 CYP17A1 0.0071
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0071
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.007
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.007
558 Solute carrier family 12 member 1 SLC12A1 0.007
193 Beta-1 adrenergic receptor ADRB1 0.0069
4122 Histone deacetylase 2 HDAC2 0.0069
952 Dipeptidyl peptidase 4 DPP4 0.0069
723 Cytosolic phospholipase A2 PLA2G4A 0.0069
251 Alcohol dehydrogenase 1A ADH1A 0.0069
49 Endothelin B receptor EDNRB 0.0069
68 Cannabinoid receptor 1 CNR1 0.0069
3947 Xanthine dehydrogenase/oxidase XDH 0.0069
444 Alcohol dehydrogenase 1B ADH1B 0.0068
844 Epidermal growth factor receptor EGFR 0.0068
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0068
823 Fibroblast growth factor receptor 2 FGFR2 0.0067
407 Vascular endothelial growth factor receptor 2 KDR 0.0067
161 Tubulin beta chain TUBB 0.0066
312 Tubulin beta chain TUB2 0.0066
378 Alpha-2C adrenergic receptor ADRA2C 0.0066
1275 Estrogen sulfotransferase SULT1E1 0.0066
6043 Putative G-protein coupled receptor 44 GPR44 0.0065
6103 Arylamine N-acetyltransferase 1 NAT1 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
716 5-hydroxytryptamine 7 receptor HTR7 0.0065
1629 Transcription factor AP-1 JUN 0.0064
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0064
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0064
1050 Bile salt sulfotransferase SULT2A1 0.0063
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0063
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0063
133 Dihydropterate synthase sulI 0.0063
6126 Carbonic anhydrase 7 CA7 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
7 Nitric oxide synthase, inducible NOS2 0.0061
814 Ryanodine receptor 1 RYR1 0.0061
432 D(4) dopamine receptor DRD4 0.006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.006
756 Sex hormone-binding globulin SHBG 0.0059
3808 Dihydropteroate synthase 2 folP2 0.0059
3601 Dihydropteroate synthase 1 folP1 0.0059
3807 Dihydropteroate synthase 1 folP1 0.0059
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0059
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
634 Squalene monooxygenase SQLE 0.0059
7196 Squalene monooxygenase ERG1 0.0059
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0058
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0058
818 50S ribosomal protein L10 rplJ 0.0058
6138 Multidrug resistance protein 3 ABCB4 0.0058
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
88 Retinoic acid receptor RXR-beta RXRB 0.0057
518 Peroxidase/catalase T katG 0.0057
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0057
153 Dopamine beta-hydroxylase DBH 0.0057
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0057
703 NADPH azoreductase azr 0.0056
1192 Sulfotransferase 1A1 SULT1A1 0.0056
24 Thymidylate synthase TMP1 0.0055
359 Thymidylate synthase TYMS 0.0055
2626 Thymidylate synthase thyA 0.0055
2729 Thymidylate synthase thyA 0.0055
5352 Thymidylate synthase THYA 0.0055
183 Vascular endothelial growth factor A VEGFA 0.0055
4120 NADPH--cytochrome P450 reductase POR 0.0055
737 Mineralocorticoid receptor NR3C2 0.0054
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0053
228 Beta platelet-derived growth factor receptor PDGFRB 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
517 Alcohol dehydrogenase 1C ADH1C 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
461 Glycine receptor subunit alpha-3 GLRA3 0.0053
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
3932 Glutathione S-transferase A2 GSTA2 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0051
459 Retinoic acid receptor RXR-alpha RXRA 0.005
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0049
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0049
6033 High affinity interleukin-8 receptor A CXCR1 0.0049
2230 Catalase CAT 0.0049
3249 Catalase katA 0.0049
3625 Catalase katA 0.0049
4539 Catalase katA 0.0049
4941 Catalase katB 0.0049
856 Vitamin D3 receptor VDR 0.0049
1483 Membrane copper amine oxidase AOC3 0.0048
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0047
904 Glutathione S-transferase P GSTP1 0.0047
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0047
6146 High affinity copper uptake protein 1 SLC31A1 0.0046
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0046
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0046
26 Vascular endothelial growth factor receptor 3 FLT4 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
527 Prostacyclin receptor PTGIR 0.0045
2207 Rhodopsin RHO 0.0045
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
474 Acetylcholinesterase ACHE 0.0045
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
3809 Estrogen-related receptor gamma ESRRG 0.0044
284 DNA-directed RNA polymerase beta chain rpoB 0.0044
5773 DNA-directed RNA polymerase beta chain rpoB 0.0044
32 Vascular endothelial growth factor receptor 1 FLT1 0.0044
528 5-hydroxytryptamine 1E receptor HTR1E 0.0043
1618 High affinity nerve growth factor receptor NTRK1 0.0043
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0043
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0043
54 Prothrombin F2 0.0042
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
106 Cannabinoid receptor 2 CNR2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
124 Histamine H2 receptor HRH2 0.004
908 Glutathione S-transferase theta-1 GSTT1 0.004
780 Retinoic acid receptor RXR-gamma RXRG 0.0039
4132 Chloride channel protein ClC-Ka CLCNKA 0.0039
1374 Natriuretic peptides B NPPB 0.0039
1827 Gap junction alpha-1 protein GJA1 0.0039
1908 Vascular cell adhesion protein 1 VCAM1 0.0039
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0039
6149 Solute carrier family 22 member 10 SLC22A10 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
489 Monocarboxylate transporter 2 SLC16A7 0.0038
6131 Carbonic anhydrase 14 CA14 0.0037
1256 5-hydroxytryptamine 6 receptor HTR6 0.0037
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
4103 Proteasome subunit beta type 2 PSMB2 0.0037
4102 Proteasome subunit beta type 5 PSMB5 0.0037
4101 Proteasome subunit beta type 1 PSMB1 0.0037
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0036
1656 CYP2B protein CYP2B 0.0036
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0036
3404 Exotoxin A eta 0.0036
319 Opioid receptor, sigma 1 OPRS1 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0035
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0035
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0035
563 Thyroid peroxidase TPO 0.0035
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
273 Apoptosis regulator Bcl-2 BCL2 0.0035
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0035
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
84 Nuclear receptor 0B1 NR0B1 0.0034
1650 Heme carrier protein 1 SLC46A1 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0034
976 Platelet glycoprotein IX GP9 0.0034
469 Annexin A1 ANXA1 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0033
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0033
5880 Thrombopoietin receptor MPL 0.0033
239 Coagulation factor X F10 0.0033
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0033
163 D(1B) dopamine receptor DRD5 0.0033
162 Retinoic acid receptor gamma-1 RARG 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0032
1268 Neuropeptide S receptor NPSR1 0.0032
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0032
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0032
4192 DNA topoisomerase 2-beta TOP2B 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
4311 tRNA TRDMT1 0.003
4325 tRNA trmD 0.003
4328 tRNA trmD 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
3913 Glutamic acid decarboxylase GAD65 0.003
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2298 Cytochrome P450-cam camC 0.003
3917 Methylenetetrahydrofolate reductase MTHFR 0.003
174 Sigma 1-type opioid receptor SIGMAR1 0.003
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.003
2236 Casein kinase II subunit alpha CSNK2A1 0.0029
6073 Potassium channel subfamily K member 9 KCNK9 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
6072 Potassium channel subfamily K member 3 KCNK3 0.0029
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
268 Adenosine A2b receptor ADORA2B 0.0028
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
5787 Angiopoietin-1 receptor TEK 0.0027
358 Cystathionine beta-synthase CBS 0.0027
164 Histamine H4 receptor HRH4 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0027
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0027
6500 Phospholipase A2 PLA2G1B 0.0026
1714 Mitogen-activated protein kinase 3 MAPK3 0.0026
33 Cystine/glutamate transporter SLC7A11 0.0026
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0026
2021 Thrombomodulin THBD 0.0026
3856 Fibroblast growth factor receptor 3 FGFR3 0.0026
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0026
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
165 FL cytokine receptor FLT3 0.0025
735 Alanine aminotransferase 1 GPT 0.0025
3904 Alanine aminotransferase 2 GPT2 0.0025
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
229 Retinoic acid receptor beta RARB 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1039 Histone deacetylase 9 HDAC9 0.0024
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0022
1992 Vitamin D-binding protein GC 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
751 Potassium channel subfamily K member 6 KCNK6 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
2232 Interleukin-5 IL5 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0021
1630 Integrin beta-2 ITGB2 0.0021
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0021
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
4217 Telomerase reverse transcriptase TERT 0.002
6432 Transporter snf 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
1864 RET proto-oncogene RET 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0019
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0019
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
3957 Adenosine deaminase ADA 0.0019
896 Glutathione S-transferase Mu 1 GSTM1 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0019
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
3221 Cytochrome c4 cc4 0.0018
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0018
683 Potassium transporter GK0582 0.0018
1792 Tissue-type plasminogen activator PLAT 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6459 Glycodelin PAEP 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0017
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0017
6044 Serum paraoxonase/lactonase 3 PON3 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
4773 Deoxycytidine kinase DCK 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0017
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0017
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0017
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0017
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0017
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
572 Integrin alpha-L ITGAL 0.0016
173 Toll-like receptor 7 TLR7 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
822 Aldose reductase AKR1B1 0.0016
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0016
3233 Bile acid receptor NR1H4 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
936 Ephrin type-A receptor 2 EPHA2 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0015
1341 Histamine H3 receptor HRH3 0.0014
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
605 Fumarate reductase flavoprotein subunit frdA 0.0014
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0014
3673 Fumarate reductase flavoprotein subunit fccA 0.0014
4912 Fumarate reductase flavoprotein subunit ifcA 0.0014
6549 Fumarate reductase flavoprotein subunit frdA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
6218 Pannexin-1 PANX1 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
6163 Copper-transporting ATPase 2 ATP7B 0.0014
6165 Copper-transporting ATPase 1 ATP7A 0.0014
6042 Prostaglandin reductase 2 PTGR2 0.0013
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0013
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0013
400 Coagulation factor IX F9 0.0013
5461 Coagulation factor IX F9 0.0013
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
291 Nitric-oxide synthase, endothelial NOS3 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0012
604 Vitamin K-dependent protein Z PROZ 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0012
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0012
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
422 Vitamin K-dependent protein C PROC 0.0011
1245 Vitamin K-dependent protein S PROS1 0.0011
4692 A/G-specific adenine glycosylase mutY 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
4386 Hemoglobin-like protein HbN glbN 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
1313 Lactoylglutathione lyase GLO1 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
5251 Carbonyl reductase [NADPH] 1 CBR1 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
283 SEC14-like protein 2 SEC14L2 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
2802 Endoglucanase G celCCG 0.001
760 Fibroblast growth factor 1 FGF1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6677 Myelin P2 protein PMP2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
798 Osteocalcin BGLAP 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
4954 Soluble cytochrome b558 Not Available 0.0009
4916 Cyanoglobin glbN 0.0009
4934 Cytochrome c-551 nirM 0.0009
5218 Cytochrome c-551 nirM 0.0009
4947 Bacterial hemoglobin vhb 0.0009
4943 Cytochrome c6 petJ 0.0009
4915 Cytochrome c-550 psbV 0.0009
4959 Cytochrome c-550 psbV 0.0009
5216 Cytochrome c-550 psbV 0.0009
4925 Cytochrome c-type protein SHP shp 0.0009
4905 Cytochrome c2 Not Available 0.0009
4939 Cytochrome c2 cycA 0.0009
4964 Cytochrome c2 cycA 0.0009
4979 Cytochrome c2 cycA 0.0009
6673 Cytochrome c2 cycA 0.0009
4975 Cytochrome c-556 RPA3973 0.0009
4994 Hemoglobin-like protein HbO glbO 0.0009
4936 Cytochrome c2 iso-2 Not Available 0.0009
4984 Neuroglobin NGB 0.0009
4998 Hemoglobin-like protein yjbI yjbI 0.0009
4942 Diheme cytochrome c napB napB 0.0009
4961 Hemophore HasA hasA 0.0009
4909 CooA protein cooA 0.0009
4981 Iron-starvation protein PigA pigA 0.0009
5000 HemO hemO 0.0009
644 Heme oxygenase 2 HMOX2 0.0009
4982 Heme oxygenase 2 pbsA2 0.0009
4904 Cytochrome c family protein GSU1996 0.0009
4907 Cytochrome c-L moxG 0.0009
6865 Cytochrome c-L moxG 0.0009
4910 Cytoglobin CYGB 0.0009
4976 Apocytochrome f petA 0.0009
6407 Apocytochrome f petA 0.0009
4971 Nonaheme cytochrome c hmcA 0.0009
4935 Cytochrome c-554 cycA1 0.0009
4989 Cytochrome c551 peroxidase ccp 0.0009
5222 Cytochrome c551 peroxidase ccpA 0.0009
4937 Cytochrome oxidase subunit II rcoxA 0.0009
4926 Heme-based aerotactic transducer hemAT hemAT 0.0009
4764 Cytochrome P450 165C4 CYP165C4 0.0009
4999 Cytochrome P450 165B3 CYP165B3 0.0009
4960 Putative cytochrome P450-family protein SCO7417 0.0009
4931 Cytochrome P450 167A1 CYP167A1 0.0009
4972 P450cin cinA 0.0009
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0009
4993 Hydroxylamine oxidoreductase hao1 0.0009
4922 Cytochrome c, putative SO_4144 0.0009
4903 Methyl-accepting chemotaxis protein Tar4 0.0009
4952 Catalase/peroxidase katA 0.0009
3093 Catalase HPII katE 0.0009
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
1184 Interferon beta IFNB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
369 Coagulation factor VII F7 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
4920 Peroxidase/catalase katG 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
4990 PpcA ppcA 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
3670 Soluble cytochrome b562 precursor cybC 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
3411 Cytochrome P450 121 cyp121 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
2430 Chondroitinase B cslB 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
4608 Putative cytochrome P450 SCO1207 0.0005
4963 Putative cytochrome P450 SCO2884 0.0005
6254 Putative cytochrome P450 SCO6998 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
693 Hemoglobin subunit beta HBB 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
1439 Lactotransferrin LTF 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
2252 Endoglucanase 5A cel5A 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
↑