DT-Web: DB01149

Identification

Name

Nefazodone

Accession Number

DB01149 (APRD00402)

Type

small molecule

Description

Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury, which could lead to the need for a liver transplant, or even death. The incidence of severe liver damage is approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States. [Wikipedia]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

470.007

Groups

approved

Monoisotopic Weight

469.224453

Pharmacology

Indication

For the treatment of depression.

Mechanism of action

Within the serotonergic system, nefazodone acts as an antagonist at type 2 serotonin (5-HT₂) post-synaptic receptors and, like fluoxetine-type antidepressants, inhibits pre-synaptic serotonin (5-HT) reuptake. These mechanisms increase the amount of serotonin available to interact with 5-HT receptors. Within the noradrenergic system, nefazodone inhibits norepinephrine uptake minimally. Nefazodone also antagonizes alpha(1)-adrenergic receptors, producing sedation, muscle relaxation, and a variety of cardiovascular effects. Nefazodone's affinity for benzodiazepine, cholinergic, dopaminergic, histaminic, and beta or alpha(2)-adrenergic receptors is not significant.

Absorption

Nefazodone is rapidly and completely absorbed. Its absolute bioavailability is low (about 20%).

Protein binding

Greater than 99% (in vitro, human plasma proteins).

Biotransformation

Hepatic.

Route of elimination

Nefazodone is extensively metabolized after oral administration by n-dealkylation and aliphatic and aromatic hydroxylation, and less than 1% of administered nefazodone is excreted unchanged in urine.

Toxicity

Cases of life-threatening hepatic failure have been reported in patients treated with nefazodone.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abiraterone	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Almotriptan	Increased risk of CNS adverse effects
Aprepitant	This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Astemizole	Increased risk of cardiotoxicity and arrhythmias
Atorvastatin	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of atorvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if nefazodone is initiated, discontinued or dose changed.
Bromazepam	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if nefazodone is initiated, discontinued or dose changed. Dosage adjustments may be required.
Buspirone	Nefazodone increases the effect of buspirone
Cabazitaxel	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Carbamazepine	Nefazodone increases the effect of carbamazepine
Cerivastatin	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of cerivastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cerivastatin if nefazodone is initiated, discontinued or dose changed.
Cilostazol	Nefazodone increases the effect of cilostazol
Cisapride	Nefazodone increases serum levels of cisapride
Cyclosporine	The antidepressant increases the effect and toxicity of cyclosporine
Dabigatran etexilate	P-Glycoprotein inducers such as nefazodone may decrease the serum concentration of dabigatran etexilate. This combination should be avoided.
Dabrafenib	Strong CYP3A4 inhibitors may increase levels of dabrafenib. Consider alternate therapy.
Dantrolene	Nefazodone may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if nefazodone is initiated, discontinued or dose changed.
Darifenacin	This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroergotamine	Possible ergotism and severe ischemia with this combination
Dronedarone	Nefazodone is a strong CYP3A4 inhibitor in which concomitant use with dronedarone will significantly increase its exposure. Avoid concomitant use.
Eletriptan	Increased risk of CNS adverse effects
Eplerenone	Nefazodone increases the effect and toxicity of eplerenone
Ergotamine	Possible ergotism and severe ischemia with this combination
Erlotinib	This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Frovatriptan	Increased risk of CNS adverse effects
Isocarboxazid	Possible severe adverse reaction with this combination
Linezolid	Combination associated with possible serotoninergic syndrome
Loratadine	Increased risk of cardiotoxicity
Lovastatin	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of lovastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of lovastatin if nefazodone is initiated, discontinued or dose changed.
Naratriptan	Increased risk of CNS adverse effects
Pazopanib	Affects CYP3A4 metabolism therefore will decrease levels or effect of pazopanib. Consider alternate therapy.
Phenelzine	Possible severe adverse reaction with this combination
Pimozide	Nefazodone may increase the effect and toxicity of pimozide.
Ponatinib	Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Rasagiline	Possible severe adverse reaction with this combination
Rizatriptan	Increased risk of CNS adverse effects
Saxagliptin	Nefazodone is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Sibutramine	Risk of serotoninergic syndrome
Simvastatin	Nefazodone may increase the effect and toxicity of simvastatin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of simvastatin if nefazodone is initiated, discontinued or dose changed.
Solifenacin	This potent CYP3A4 inhibitor slows darifenacin/solifenacin metabolism
St. John's Wort	St. John's Wort increases the effect and toxicity of the SSRI, nefazodone.
Sumatriptan	Increased risk of CNS adverse effects
Sunitinib	Possible increase in sunitinib levels
Tacrolimus	Nefazodone may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Nefazodone therapy is initiated, discontinued or altered.
Tadalafil	Nefazodone may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen	Nefazodone may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Tamsulosin	Nefazodone, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Nefazodone is initiated, discontinued, or dose changed.
Telithromycin	Co-administration may result in altered plasma concentrations of Nefazodone and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents.
Temsirolimus	Nefazodone may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide	The strong CYP3A4 inhibitor, Nefazodone, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Nefazodone is initiated, discontinued or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Nefazodone. Consider alternate therapy or monitor for therapeutic/adverse effects of Nefazodone if Terbinafine is initiated, discontinued or dose changed.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Tiagabine	The strong CYP3A4 inhibitor, Nefazodone, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Nefazodone is initiated, discontinued or dose changed.
Tolterodine	Nefazodone may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tolvaptan	Nefazodone is a strong inhibitor of CYP3A4 and will increase serum concentrations of tolvaptan.
Tramadol	Nefazodone may increase tramadol toxicity by decreasing tramadol metabolism and clearance. Increased risk of serotonin syndrome. Monitor for tramadol toxicity and symptoms of serotonin syndrome.
Tranylcypromine	Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trazodone	Increased risk of serotonin syndrome. The CYP3A4 inhibitor, Nefazodone, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for symtpoms of sertonin syndrome and changes in Trazodone efficacy/toxicity if Nefazodone is initiated, discontinued or dose changed.
Triazolam	Nefazodone increases the effect of triazolam
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. Nefazodone, a strong CYP3A4 inhibitor, may also decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Nefazodone is initiated, discontinued or dose changed.
Triprolidine	The CNS depressants, Triprolidine and Nefazodone, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Vardenafil	Nefazodone, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Vemurafenib	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Verapamil	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Nefazodone is initiated, discontinued or dose changed.
Vinblastine	Nefazodone, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Nefazodone is initiated, discontinued or dose changed.
Vincristine	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Nefazodone is initiated, discontinued or dose changed.
Vinorelbine	Nafazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Nefazodone is initiated, discontinued or dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of nefazodone by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nefazodone if voriconazole is initiated, discontinued or dose changed.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and nafazodone, may increase the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zolpidem	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if nefazodone is initiated, discontinued or dose changed.
Zonisamide	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if nefazodone is initiated, discontinued or dose changed.
Zopiclone	Nefazodone, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if nefazodone is initiated, discontinued or dose changed.

Food Interactions

Take this medication either consistently with or without food as instructed by your doctor.
Avoid alcohol.
Avoid avocado.
Limit garlic, ginger, gingko, and horse chestnut.

5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	yes
Actions	antagonist
References	Hidalgo R, Hertzberg MA, Mellman T, Petty F, Tucker P, Weisler R, Zisook S, Chen S, Churchill E, Davidson J: Nefazodone in post-traumatic stress disorder: results from six open-label trials. Int Clin Psychopharmacol. 1999 Mar;14(2):61-8. - Pubmed Meyer JH, Cho R, Kennedy S, Kapur S: The effects of single dose nefazodone and paroxetine upon 5-HT2A binding potential in humans using [18F]-setoperone PET. Psychopharmacology (Berl). 1999 Jun;144(3):279-81. - Pubmed Horton JC, Trobe JD: Akinetopsia from nefazodone toxicity. Am J Ophthalmol. 1999 Oct;128(4):530-1. - Pubmed Eckler JR, Rabin RA, Winter JC: Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control. Pharmacol Biochem Behav. 2003 May;75(2):405-10. - Pubmed Avila A, Cardona X, Martin-Baranera M, Maho P, Sastre F, Bello J: Does nefazodone improve both depression and Parkinson disease? A pilot randomized trial. J Clin Psychopharmacol. 2003 Oct;23(5):509-13. - Pubmed Taylor DP, Carter RB, Eison AS, Mullins UL, Smith HL, Torrente JR, Wright RN, Yocca FD: Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry. 1995;56 Suppl 6:3-11. - Pubmed Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed Davis R, Whittington R, Bryson HM: Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs. 1997 Apr;53(4):608-36. - Pubmed
DTHybrid score	0.4976
5-hydroxytryptamine 2C receptor
Name	5-hydroxytryptamine 2C receptor
Gene Name	HTR2C
Pharmacological action	yes
Actions	antagonist
References	Millan MJ: Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie. 2005 Sep-Oct;60(5):441-60. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3561
Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Owens MJ, Ieni JR, Knight DL, Winders K, Nemeroff CB: The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies. Life Sci. 1995;57(24):PL373-80. - Pubmed Narayan M, Anderson G, Cellar J, Mallison RT, Price LH, Nelson JC: Serotonin transporter-blocking properties of nefazodone assessed by measurement of platelet serotonin. J Clin Psychopharmacol. 1998 Feb;18(1):67-71. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed Taylor DP, Carter RB, Eison AS, Mullins UL, Smith HL, Torrente JR, Wright RN, Yocca FD: Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry. 1995;56 Suppl 6:3-11. - Pubmed Davis R, Whittington R, Bryson HM: Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs. 1997 Apr;53(4):608-36. - Pubmed
DTHybrid score	0.6057
5-hydroxytryptamine 1A receptor
Name	5-hydroxytryptamine 1A receptor
Gene Name	HTR1A
Pharmacological action	yes
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.4026
Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	yes
Actions	inhibitor
References	Owens MJ, Ieni JR, Knight DL, Winders K, Nemeroff CB: The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies. Life Sci. 1995;57(24):PL373-80. - Pubmed Owen D, Du L, Bakish D, Lapierre YD, Hrdina PD: Norepinephrine transporter gene polymorphism is not associated with susceptibility to major depression. Psychiatry Res. 1999 Jul 30;87(1):1-5. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed Taylor DP, Carter RB, Eison AS, Mullins UL, Smith HL, Torrente JR, Wright RN, Yocca FD: Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry. 1995;56 Suppl 6:3-11. - Pubmed Davis R, Whittington R, Bryson HM: Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs. 1997 Apr;53(4):608-36. - Pubmed
DTHybrid score	0.7416
Sodium-dependent dopamine transporter
Name	Sodium-dependent dopamine transporter
Gene Name	SLC6A3
Pharmacological action	unknown
Actions	inhibitor
References	Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score	0.652
Alpha-1B adrenergic receptor
Name	Alpha-1B adrenergic receptor
Gene Name	ADRA1B
Pharmacological action	unknown
Actions	other/unknown
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score	0.4468
Alpha-2A adrenergic receptor
Name	Alpha-2A adrenergic receptor
Gene Name	ADRA2A
Pharmacological action	unknown
Actions	antagonist
References	Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.5453
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	no
Actions	antagonist
References	Taylor DP, Carter RB, Eison AS, Mullins UL, Smith HL, Torrente JR, Wright RN, Yocca FD: Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry. 1995;56 Suppl 6:3-11. - Pubmed Cusack B, Nelson A, Richelson E: Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. - Pubmed
DTHybrid score	0.6969

Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4592
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3595
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Davis R, Whittington R, Bryson HM: Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression. Drugs. 1997 Apr;53(4):608-36. - Pubmed DeVane CL, Donovan JL, Liston HL, Markowitz JS, Cheng KT, Risch SC, Willard L: Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers. J Clin Psychopharmacol. 2004 Feb;24(1):4-10. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed von Moltke LL, Greenblatt DJ, Granda BW, Grassi JM, Schmider J, Harmatz JS, Shader RI: Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. Psychopharmacology (Berl). 1999 Jul;145(1):113-22. - Pubmed
DTHybrid score	0.8777
CYP2B protein
Name	CYP2B protein
Gene Name	CYP2B
Actions	inhibitor
References	Haduch A, Wojcikowski J, Daniel WA: Effect of selected antidepressant drugs on cytochrome P450 2B (CYP2B) in rat liver. An in vitro and in vivo study. Pharmacol Rep. 2008 Nov-Dec;60(6):957-65. - Pubmed
DTHybrid score	0.2715
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	von Moltke LL, Greenblatt DJ, Granda BW, Grassi JM, Schmider J, Harmatz JS, Shader RI: Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. Psychopharmacology (Berl). 1999 Jul;145(1):113-22. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8061

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inducer
References	Stormer E, von Moltke LL, Perloff MD, Greenblatt DJ: P-glycoprotein interactions of nefazodone and trazodone in cell culture. J Clin Pharmacol. 2001 Jul;41(7):708-14. - Pubmed
DTHybrid score	0.5553

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.3708
6016	Cytochrome P450 2C19	CYP2C19	0.3198
831	D(2) dopamine receptor	DRD2	0.3168
4757	Cytochrome P450 2C9	CYP2C9	0.3092
492	Histamine H1 receptor	HRH1	0.2897
23	D(1A) dopamine receptor	DRD1	0.2612
629	Alpha-2B adrenergic receptor	ADRA2B	0.2258
378	Alpha-2C adrenergic receptor	ADRA2C	0.2151
6030	Cytochrome P450 2B6	CYP2B6	0.214
103	Muscarinic acetylcholine receptor M1	CHRM1	0.2061
789	Alpha-1D adrenergic receptor	ADRA1D	0.2001
4924	Cytochrome P450 2C8	CYP2C8	0.1947
436	5-hydroxytryptamine 2B receptor	HTR2B	0.1685
3941	Amine oxidase [flavin-containing] A	MAOA	0.1548
638	D(3) dopamine receptor	DRD3	0.1538
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1501
6013	Cytochrome P450 2E1	CYP2E1	0.1488
131	Synaptic vesicular amine transporter	SLC18A2	0.1485
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1469
725	5-hydroxytryptamine 1D receptor	HTR1D	0.142
432	D(4) dopamine receptor	DRD4	0.1418
766	Beta-2 adrenergic receptor	ADRB2	0.1318
193	Beta-1 adrenergic receptor	ADRB1	0.1269
587	Serum albumin	ALB	0.1163
51	Muscarinic acetylcholine receptor M3	CHRM3	0.1111
716	5-hydroxytryptamine 7 receptor	HTR7	0.1099
6145	Solute carrier family 22 member 1	SLC22A1	0.1089
163	D(1B) dopamine receptor	DRD5	0.1075
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1048
6024	Cytochrome P450 1A1	CYP1A1	0.1018
3939	Amine oxidase [flavin-containing] B	MAOB	0.1013
274	Muscarinic acetylcholine receptor M5	CHRM5	0.1005
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0979
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0869
5718	Cytochrome P450 2A6	CYP2A6	0.0829
6144	Solute carrier family 22 member 2	SLC22A2	0.0745
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0743
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0733
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0714
3923	Cholinesterase	BCHE	0.0708
847	Mu-type opioid receptor	OPRM1	0.059
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0573
3811	Cytochrome P450 19A1	CYP19A1	0.055
6106	Cytochrome P450 2C18	CYP2C18	0.0538
6147	Solute carrier family 22 member 3	SLC22A3	0.0526
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0522
118	Organic cation/carnitine transporter 2	SLC22A5	0.0518
862	Multidrug resistance-associated protein 1	ABCC1	0.0516
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0514
696	Kappa-type opioid receptor	OPRK1	0.0514
467	Delta-type opioid receptor	OPRD1	0.0484
94	5-hydroxytryptamine 4 receptor	HTR4	0.0476
1636	Trace amine-associated receptor 1	TAAR1	0.0473
1517	Beta-3 adrenergic receptor	ADRB3	0.0435
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0417
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0408
20	Prostaglandin G/H synthase 1	PTGS1	0.0408
776	Bile salt export pump	ABCB11	0.0387
871	Glucocorticoid receptor	NR3C1	0.0384
290	Prostaglandin G/H synthase 2	PTGS2	0.0378
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0364
3947	Xanthine dehydrogenase/oxidase	XDH	0.0363
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.036
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0349
1898	Cytochrome P450 1B1	CYP1B1	0.0347
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.034
124	Histamine H2 receptor	HRH2	0.0328
6031	Cytochrome P450 3A43	CYP3A43	0.0316
474	Acetylcholinesterase	ACHE	0.031
6182	Cytochrome P450 2J2	CYP2J2	0.0308
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0304
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0295
1729	Solute carrier family 22 member 6	SLC22A6	0.0287
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0287
465	Calmodulin	CALM1	0.0285
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0283
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0279
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0276
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0275
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.027
731	HIV-1 protease	HIV-1 protease	0.0269
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0265
833	Organic cation/carnitine transporter 1	SLC22A4	0.0253
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0252
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.025
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.025
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0248
6432	Transporter	snf	0.0244
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0241
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0236
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0235
4120	NADPH--cytochrome P450 reductase	POR	0.0231
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0229
828	Phenylalanine-4-hydroxylase	PAH	0.0225
3109	Phenylalanine-4-hydroxylase	phhA	0.0225
174	Sigma 1-type opioid receptor	SIGMAR1	0.0223
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0219
6143	Solute carrier family 22 member 7	SLC22A7	0.0217
614	Progesterone receptor	PGR	0.0212
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.021
817	DNA topoisomerase 2-alpha	TOP2A	0.0209
136	Estrogen receptor	ESR1	0.0206
260	Cytochrome P450 51	ERG11	0.0204
761	Cytochrome P450 51	ERG11	0.0204
3163	Cytochrome P450 51	cyp51	0.0204
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0196
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0188
6148	Multidrug resistance-associated protein 7	ABCC10	0.0187
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0187
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0186
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0176
6142	Solute carrier family 22 member 8	SLC22A8	0.0176
737	Mineralocorticoid receptor	NR3C2	0.0175
2164	Multidrug resistance-associated protein 4	ABCC4	0.0172
232	Corticosteroid-binding globulin	SERPINA6	0.0166
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0164
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0163
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0163
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0161
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0155
6138	Multidrug resistance protein 3	ABCB4	0.0155
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0147
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0147
844	Epidermal growth factor receptor	EGFR	0.0146
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0144
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0144
6020	Aldehyde oxidase	AOX1	0.0139
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0138
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0137
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0136
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0136
504	Mast/stem cell growth factor receptor	KIT	0.0135
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0135
1757	Myeloperoxidase	MPO	0.0134
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0134
3426	Glutamine synthetase	glnA	0.0133
3987	Glutamine synthetase	GLUL	0.0133
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0132
468	Cytochrome P450 4A11	CYP4A11	0.0132
4604	Liver carboxylesterase 1	CES1	0.0131
756	Sex hormone-binding globulin	SHBG	0.0131
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0129
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0128
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0124
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0124
818	50S ribosomal protein L10	rplJ	0.0122
952	Dipeptidyl peptidase 4	DPP4	0.0121
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0121
904	Glutathione S-transferase P	GSTP1	0.012
3810	Catechol O-methyltransferase	COMT	0.012
161	Tubulin beta chain	TUBB	0.0119
312	Tubulin beta chain	TUB2	0.0119
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0117
380	Cytochrome P450 17A1	CYP17A1	0.0117
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0116
811	Translocator protein	TSPO	0.0116
362	Melatonin receptor type 1B	MTNR1B	0.0115
571	Melatonin receptor type 1A	MTNR1A	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0112
29	Tubulin beta-1 chain	TUBB1	0.0111
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0111
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0111
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.011
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.011
477	DNA topoisomerase 4 subunit A	parC	0.0109
886	DNA topoisomerase 4 subunit A	parC	0.0109
6226	DNA topoisomerase 4 subunit A	parC	0.0109
1618	High affinity nerve growth factor receptor	NTRK1	0.0109
26	Vascular endothelial growth factor receptor 3	FLT4	0.0108
404	DNA gyrase subunit A	gyrA	0.0108
6224	DNA gyrase subunit A	gyrA	0.0108
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0107
407	Vascular endothelial growth factor receptor 2	KDR	0.0106
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0106
32	Vascular endothelial growth factor receptor 1	FLT1	0.0103
6137	Multidrug resistance-associated protein 6	ABCC6	0.0102
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0101
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0101
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0101
146	Androgen receptor	AR	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0099
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0098
4237	50S ribosomal protein L22	rplV	0.0095
6141	Sodium/bile acid cotransporter	SLC10A1	0.0094
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0093
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0093
122	P2Y purinoceptor 12	P2RY12	0.0092
319	Opioid receptor, sigma 1	OPRS1	0.0091
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0091
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0091
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0091
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0091
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0091
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0091
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.009
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.009
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0088
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0088
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
777	Tumor necrosis factor	TNF	0.0087
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0087
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0086
6136	Multidrug resistance-associated protein 5	ABCC5	0.0086
1010	Cytochrome P450 51A1	CYP51A1	0.0085
6220	Aryl hydrocarbon receptor	AHR	0.0085
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0084
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0083
869	Estrogen receptor beta	ESR2	0.0083
4238	50S ribosomal protein L4	rplD	0.0083
5578	50S ribosomal protein L4	rplD	0.0083
6173	50S ribosomal protein L4	rplD	0.0083
6219	50S ribosomal protein L4	rplD	0.0083
164	Histamine H4 receptor	HRH4	0.0082
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0082
1192	Sulfotransferase 1A1	SULT1A1	0.0082
233	Potassium channel subfamily K member 2	KCNK2	0.0081
1024	Solute carrier family 22 member 11	SLC22A11	0.008
2112	Toll-like receptor 9	TLR9	0.008
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.008
1353	DNA topoisomerase 1	TOP1	0.008
3552	DNA topoisomerase 1	topA	0.008
1852	Microtubule-associated protein 2	MAP2	0.0079
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0079
6151	Monocarboxylate transporter 10	SLC16A10	0.0078
244	Angiotensin-converting enzyme	ACE	0.0076
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0076
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0076
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0076
2539	Tubulin alpha-1 chain	TUBA4A	0.0076
923	Glutamate receptor 3	GRIA3	0.0075
6070	Nischarin	NISCH	0.0075
165	FL cytokine receptor	FLT3	0.0075
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0075
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0075
427	Substance-P receptor	TACR1	0.0074
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0074
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0074
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0073
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0073
705	Glutamate receptor 1	GRIA1	0.0072
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0072
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0072
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0071
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0071
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.007
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0068
814	Ryanodine receptor 1	RYR1	0.0067
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0067
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0067
921	Glutamate receptor 2	GRIA2	0.0067
70	Type-1 angiotensin II receptor	AGTR1	0.0066
738	Monocarboxylate transporter 1	SLC16A1	0.0066
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0064
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
469	Annexin A1	ANXA1	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
2449	Tubulin alpha-3 chain	TUBA1A	0.0062
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0062
1178	Adenosine A2a receptor	ADORA2A	0.0062
153	Dopamine beta-hydroxylase	DBH	0.0061
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.006
1050	Bile salt sulfotransferase	SULT2A1	0.006
482	Glycine receptor subunit alpha-1	GLRA1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0059
5923	Microtubule-associated protein tau	MAPT	0.0059
5924	Microtubule-associated protein 4	MAP4	0.0059
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
239	Coagulation factor X	F10	0.0058
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
373	Transthyretin	TTR	0.0056
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0056
273	Apoptosis regulator Bcl-2	BCL2	0.0056
4203	Histamine N-methyltransferase	HNMT	0.0055
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0055
6506	Stathmin-4	STMN4	0.0055
4773	Deoxycytidine kinase	DCK	0.0055
6102	Arylamine N-acetyltransferase 2	NAT2	0.0054
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0053
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0052
5300	Antigen peptide transporter 1	TAP1	0.0051
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
295	Carbonic anhydrase 1	CA1	0.005
3932	Glutathione S-transferase A2	GSTA2	0.005
173	Toll-like receptor 7	TLR7	0.0049
1483	Membrane copper amine oxidase	AOC3	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
6014	Cytochrome P450 2A13	CYP2A13	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
6859	Protein S100-A4	S100A4	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0046
3086	Plasmepsin-2	Not Available	0.0046
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
68	Cannabinoid receptor 1	CNR1	0.0045
54	Prothrombin	F2	0.0045
1629	Transcription factor AP-1	JUN	0.0045
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0045
16	Adenosine A1 receptor	ADORA1	0.0044
84	Nuclear receptor 0B1	NR0B1	0.0044
284	DNA-directed RNA polymerase beta chain	rpoB	0.0044
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0044
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0044
365	Dihydrofolate reductase	DHFR	0.0044
2381	Dihydrofolate reductase	DFR1	0.0044
2833	Dihydrofolate reductase	Not Available	0.0044
2931	Dihydrofolate reductase	folA	0.0044
3544	Dihydrofolate reductase	folA	0.0044
3682	Dihydrofolate reductase	folA	0.0044
6642	Dihydrofolate reductase	folA	0.0044
6756	Dihydrofolate reductase	dfrA	0.0044
4122	Histone deacetylase 2	HDAC2	0.0043
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
1630	Integrin beta-2	ITGB2	0.0041
976	Platelet glycoprotein IX	GP9	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
856	Vitamin D3 receptor	VDR	0.004
3856	Fibroblast growth factor receptor 3	FGFR3	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
592	Carbonic anhydrase 4	CA4	0.0038
6824	Tyrosine-protein kinase Lyn	LYN	0.0038
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0037
4311	tRNA	TRDMT1	0.0037
4325	tRNA	trmD	0.0037
4328	tRNA	trmD	0.0037
823	Fibroblast growth factor receptor 2	FGFR2	0.0037
891	Dihydropteroate synthase	folP	0.0037
5359	Dihydropteroate synthase	folP	0.0037
7175	Dihydropteroate synthase	sulI	0.0037
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0036
2808	Chloramphenicol acetyltransferase 3	cat3	0.0036
1374	Natriuretic peptides B	NPPB	0.0036
1827	Gap junction alpha-1 protein	GJA1	0.0036
1908	Vascular cell adhesion protein 1	VCAM1	0.0036
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0035
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6048	Troponin C, skeletal muscle	TNNC2	0.0035
780	Retinoic acid receptor RXR-gamma	RXRG	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6085	Fatty acid-binding protein, intestinal	FABP2	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0034
4103	Proteasome subunit beta type 2	PSMB2	0.0034
4102	Proteasome subunit beta type 5	PSMB5	0.0034
4101	Proteasome subunit beta type 1	PSMB1	0.0034
6044	Serum paraoxonase/lactonase 3	PON3	0.0034
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
3601	Dihydropteroate synthase 1	folP1	0.0033
3807	Dihydropteroate synthase 1	folP1	0.0033
3808	Dihydropteroate synthase 2	folP2	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
183	Vascular endothelial growth factor A	VEGFA	0.0033
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0032
2810	Dr hemagglutinin structural subunit	draA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0032
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0032
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0032
88	Retinoic acid receptor RXR-beta	RXRB	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0031
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0031
572	Integrin alpha-L	ITGAL	0.0031
5787	Angiopoietin-1 receptor	TEK	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
4192	DNA topoisomerase 2-beta	TOP2B	0.003
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.003
1864	RET proto-oncogene	RET	0.003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.003
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0029
357	Carbonic anhydrase 2	CA2	0.0029
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0028
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0028
275	Arachidonate 5-lipoxygenase	ALOX5	0.0028
3809	Estrogen-related receptor gamma	ESRRG	0.0027
24	Thymidylate synthase	TMP1	0.0027
359	Thymidylate synthase	TYMS	0.0027
2626	Thymidylate synthase	thyA	0.0027
2729	Thymidylate synthase	thyA	0.0027
5352	Thymidylate synthase	THYA	0.0027
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
5934	Cytochrome P450 26A1	CYP26A1	0.0027
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0027
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0026
2216	Fibroblast growth factor receptor 4	FGFR4	0.0026
7	Nitric oxide synthase, inducible	NOS2	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
49	Endothelin B receptor	EDNRB	0.0026
33	Cystine/glutamate transporter	SLC7A11	0.0026
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0025
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0024
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0024
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0023
936	Ephrin type-A receptor 2	EPHA2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
162	Retinoic acid receptor gamma-1	RARG	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0022
298	Renin	REN	0.0021
2300	Lysozyme	E	0.0021
3633	Lysozyme	R	0.0021
5597	Lysozyme	17	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
569	Retinal dehydrogenase 2	ALDH1A2	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
267	Plasminogen activator inhibitor 1	SERPINE1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
594	Thyroxine-binding globulin	SERPINA7	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
6126	Carbonic anhydrase 7	CA7	0.002
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
751	Potassium channel subfamily K member 6	KCNK6	0.002
611	Retinal dehydrogenase 1	ALDH1A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
6149	Solute carrier family 22 member 10	SLC22A10	0.0019
758	Thyroid hormone receptor alpha	THRA	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
65	Matrix metalloproteinase-9	Not Available	0.0019
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0019
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
6221	Steroid hormone receptor ERR1	ESRRA	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
172	Potassium channel subfamily K member 1	KCNK1	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
908	Glutathione S-transferase theta-1	GSTT1	0.0017
346	Thyroid hormone receptor beta-1	THRB	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0017
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0017
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
518	Peroxidase/catalase T	katG	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0016
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0016
1650	Heme carrier protein 1	SLC46A1	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6755	Poliovirus receptor	PVR	0.0015
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0015
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0015
3957	Adenosine deaminase	ADA	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0015
563	Thyroid peroxidase	TPO	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
4210	Toll-like receptor 4	TLR4	0.0014
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
6146	High affinity copper uptake protein 1	SLC31A1	0.0013
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0013
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
199	Monocarboxylate transporter 8	SLC16A2	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1275	Estrogen sulfotransferase	SULT1E1	0.0012
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0012
1295	Fatty acid synthase	FASN	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
291	Nitric-oxide synthase, endothelial	NOS3	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
1992	Vitamin D-binding protein	GC	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0011
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6459	Glycodelin	PAEP	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3937	Fatty-acid amide hydrolase	FAAH	0.001
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4217	Telomerase reverse transcriptase	TERT	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
2207	Rhodopsin	RHO	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.001
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
1039	Histone deacetylase 9	HDAC9	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
489	Monocarboxylate transporter 2	SLC16A7	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
6218	Pannexin-1	PANX1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
76	Nitric-oxide synthase, brain	NOS1	0.0007
125	DNA polymerase beta	POLB	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6228	Nuclear receptor coactivator 1	NCOA1	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2021	Thrombomodulin	THBD	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
293	Gamma-glutamyl hydrolase	GGH	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01149 - Nefazodone

Targets

Enzymes

Transporters

Predictions