DT-Web

DB08901 - Ponatinib


Identification
Name Ponatinib
Accession Number DB08901
Type small molecule
Description Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 532.5595
Groups approved
Monoisotopic Weight 532.219844131
Pharmacology
Indication Ponatinib is indicated for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ALL) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy.
Mechanism of action Ponatinib is a multi-target kinase inhibitor. Its primary cellular target is the Bcr-Abl tyrosine kinase protein which is constitutively active and promotes the progression of CML. This protein arises from the fused Bcr and Abl gene- what is commonly known as the Philadelphia chromosome. Ponatinib is unique in that it is especially useful in the treatment of resistant CML because it inhibits the tyrosine kinase activity of Abl and T315I mutant kinases. The T315I mutation confers resistance in cells as it prevents other Bcr-Abl inhibitors from binding to the Abl kinase. Other targets that ponatinib inhibits are members of the VEGFR, PDGFR, FGFR, EPH receptors and SRC families of kinases, and KIT, RET, TIE2, and FLT3. A decrease in tumour size expressing native or T315I mutant BCR-ABL have been observed in rats.
Absorption The absolute bioavailability of ponatinib is unknown. Peak concentrations of ponatinib are observed within 6 hours after Iclusig oral administration. Food does not affect absorption of food. The aqueous solubility of ponatinib is pH dependent, with higher pH resulting in lower solubility. When 45 mg of ponatinib is given to cancer patients, the pharmacokinetic parameters are as follows: Cmax = 73 ng/mL; AUC = 1253 ngohr/mL;
Protein binding > 99% bound to plasma proteins.
Biotransformation At least 64% of a ponatinib dose undergoes phase I and phase II metabolism. CYP3A4 and to a lesser extent CYP2C8, CYP2D6 and CYP3A5 are involved in the phase I metabolism of ponatinib in vitro. Ponatinib is also metabolized by esterases and/or amidases.
Route of elimination Ponatinib is mainly eliminated via feces. Following a single oral dose of [14C]-labeled ponatinib, approximately 87% of the radioactive dose is recovered in the feces and approximately 5% in the urine.
Toxicity The most common non-hematologic adverse reactions (>= 20%) were hypertension, rash, abdominal pain, fatigue, headache, dry skin, constipation, arthralgia, nausea, and pyrexia. Hematologic adverse reactions included thrombocytopenia, anemia, neutropenia, lymphopenia, and leukopenia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Boceprevir Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Carbamazepine Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Carbamazepine Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Clarithromycin Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Conivaptan Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Indinavir Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Itraconazole Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Ketoconazole Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Lopinavir Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Nefazodone Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Nelfinavir Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Phenytoin Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Phenytoin Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Posaconazole Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Rifampin Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Rifampin Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Ritonavir Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Ritonavir Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Saquinavir Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Telaprevir Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Telithromycin Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Voriconazole Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Food Interactions Not Available

Targets


Proto-oncogene tyrosine-protein kinase ABL1
Name Proto-oncogene tyrosine-protein kinase ABL1
Gene Name ABL1
Pharmacological action yes
Actions inhibitor
References
  • FDA label -
  • Iqbal Z, Aleem A, Iqbal M, Naqvi MI, Gill A, Taj AS, Qayyum A, ur-Rehman N, Khalid AM, Shah IH, Khalid M, Haq R, Khan M, Baig SM, Jamil A, Abbas MN, Absar M, Mahmood A, Rasool M, Akhtar T: Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era. PLoS One. 2013;8(2):e55717. doi: 10.1371/journal.pone.0055717. Epub 2013 Feb 8. - Pubmed
DTHybrid score 1.0674
Breakpoint cluster region protein
Name Breakpoint cluster region protein
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • FDA label -
  • Iqbal Z, Aleem A, Iqbal M, Naqvi MI, Gill A, Taj AS, Qayyum A, ur-Rehman N, Khalid AM, Shah IH, Khalid M, Haq R, Khan M, Baig SM, Jamil A, Abbas MN, Absar M, Mahmood A, Rasool M, Akhtar T: Sensitive detection of pre-existing BCR-ABL kinase domain mutations in CD34+ cells of newly diagnosed chronic-phase chronic myeloid leukemia patients is associated with imatinib resistance: implications in the post-imatinib era. PLoS One. 2013;8(2):e55717. doi: 10.1371/journal.pone.0055717. Epub 2013 Feb 8. - Pubmed
DTHybrid score Not Available
Mast/stem cell growth factor receptor
Name Mast/stem cell growth factor receptor
Gene Name KIT
Pharmacological action unknown
Actions inhibitor
References
  • FDA label -
  • Gleixner KV, Peter B, Blatt K, Suppan V, Reiter A, Radia D, Hadzijusufovic E, Valent P: Synergistic growth-inhibitory effects of ponatinib and midostaurin (PKC412) on neoplastic mast cells carrying KIT D816V. Haematologica. 2013 Mar 28. - Pubmed
DTHybrid score 0.5408
Proto-oncogene tyrosine-protein kinase receptor ret
Name Proto-oncogene tyrosine-protein kinase receptor ret
Gene Name RET
Pharmacological action unknown
Actions inhibitor
References
  • FDA label -
  • De Falco V, Buonocore P, Muthu M, Torregrossa L, Basolo F, Billaud M, Gozgit JM, Carlomagno F, Santoro M: Ponatinib (AP24534) Is a Novel Potent Inhibitor of Oncogenic RET Mutants Associated With Thyroid Cancer. J Clin Endocrinol Metab. 2013 May;98(5):E811-9. doi: 10.1210/jc.2012-2672. Epub 2013 Mar 22. - Pubmed
DTHybrid score 0.8841
Angiopoietin-1 receptor
Name Angiopoietin-1 receptor
Gene Name TEK
Pharmacological action unknown
Actions inhibitor
References
  • FDA label -
DTHybrid score 0.8573
FL cytokine receptor
Name FL cytokine receptor
Gene Name FLT3
Pharmacological action unknown
Actions inhibitor
References
  • FDA label -
  • Smith CC, Lasater EA, Zhu X, Lin KC, Stewart WK, Damon LE, Salerno S, Shah NP: Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. Blood. 2013 Apr 18;121(16):3165-71. doi: 10.1182/blood-2012-07-442871. Epub 2013 Feb 21. - Pubmed
DTHybrid score 0.3299
Basic fibroblast growth factor receptor 1
Name Basic fibroblast growth factor receptor 1
Gene Name FGFR1
Pharmacological action unknown
Actions inhibitor
References
  • Ren M, Hong M, Liu G, Wang H, Patel V, Biddinger P, Silva J, Cowell J, Hao Z: Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1. Oncol Rep. 2013 Jun;29(6):2181-90. doi: 10.3892/or.2013.2386. Epub 2013 Apr 4. - Pubmed
  • Gozgit JM, Squillace RM, Wongchenko MJ, Miller D, Wardwell S, Mohemmad Q, Narasimhan NI, Wang F, Clackson T, Rivera VM: Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. Cancer Chemother Pharmacol. 2013 May;71(5):1315-23. doi: 10.1007/s00280-013-2131-z. Epub 2013 Mar 7. - Pubmed
DTHybrid score 1.5479
Fibroblast growth factor receptor 2
Name Fibroblast growth factor receptor 2
Gene Name FGFR2
Pharmacological action unknown
Actions inhibitor
References
  • Gozgit JM, Squillace RM, Wongchenko MJ, Miller D, Wardwell S, Mohemmad Q, Narasimhan NI, Wang F, Clackson T, Rivera VM: Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. Cancer Chemother Pharmacol. 2013 May;71(5):1315-23. doi: 10.1007/s00280-013-2131-z. Epub 2013 Mar 7. - Pubmed
DTHybrid score 1.167
Fibroblast growth factor receptor 3
Name Fibroblast growth factor receptor 3
Gene Name FGFR3
Pharmacological action unknown
Actions inhibitor
References
  • Gozgit JM, Squillace RM, Wongchenko MJ, Miller D, Wardwell S, Mohemmad Q, Narasimhan NI, Wang F, Clackson T, Rivera VM: Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. Cancer Chemother Pharmacol. 2013 May;71(5):1315-23. doi: 10.1007/s00280-013-2131-z. Epub 2013 Mar 7. - Pubmed
DTHybrid score 0.6676
Fibroblast growth factor receptor 4
Name Fibroblast growth factor receptor 4
Gene Name FGFR4
Pharmacological action unknown
Actions inhibitor
References
  • Gozgit JM, Squillace RM, Wongchenko MJ, Miller D, Wardwell S, Mohemmad Q, Narasimhan NI, Wang F, Clackson T, Rivera VM: Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. Cancer Chemother Pharmacol. 2013 May;71(5):1315-23. doi: 10.1007/s00280-013-2131-z. Epub 2013 Mar 7. - Pubmed
DTHybrid score 0.6445
Proto-oncogene tyrosine-protein kinase LCK
Name Proto-oncogene tyrosine-protein kinase LCK
Gene Name LCK
Pharmacological action unknown
Actions inhibitor
References
  • Gushwa NN, Kang S, Chen J, Taunton J: Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors. J Am Chem Soc. 2012 Dec 19;134(50):20214-7. doi: 10.1021/ja310659j. Epub 2012 Dec 4. - Pubmed
DTHybrid score 1.5954
Proto-oncogene tyrosine-protein kinase Src
Name Proto-oncogene tyrosine-protein kinase Src
Gene Name SRC
Pharmacological action unknown
Actions inhibitor
References
  • O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, Metcalf CA 3rd, Tyner JW, Loriaux MM, Corbin AS, Wardwell S, Ning Y, Keats JA, Wang Y, Sundaramoorthi R, Thomas M, Zhou D, Snodgrass J, Commodore L, Sawyer TK, Dalgarno DC, Deininger MW, Druker BJ, Clackson T: AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028. - Pubmed
DTHybrid score 1.9571
Tyrosine-protein kinase Lyn
Name Tyrosine-protein kinase Lyn
Gene Name LYN
Pharmacological action unknown
Actions inhibitor
References
  • O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, Metcalf CA 3rd, Tyner JW, Loriaux MM, Corbin AS, Wardwell S, Ning Y, Keats JA, Wang Y, Sundaramoorthi R, Thomas M, Zhou D, Snodgrass J, Commodore L, Sawyer TK, Dalgarno DC, Deininger MW, Druker BJ, Clackson T: AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028. - Pubmed
DTHybrid score 0.6379
Vascular endothelial growth factor receptor 2
Name Vascular endothelial growth factor receptor 2
Gene Name KDR
Pharmacological action unknown
Actions inhibitor
References
  • O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, Metcalf CA 3rd, Tyner JW, Loriaux MM, Corbin AS, Wardwell S, Ning Y, Keats JA, Wang Y, Sundaramoorthi R, Thomas M, Zhou D, Snodgrass J, Commodore L, Sawyer TK, Dalgarno DC, Deininger MW, Druker BJ, Clackson T: AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028. - Pubmed
DTHybrid score 1.6385
Alpha platelet-derived growth factor receptor
Name Alpha platelet-derived growth factor receptor
Gene Name PDGFRA
Pharmacological action unknown
Actions inhibitor
References
  • O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, Metcalf CA 3rd, Tyner JW, Loriaux MM, Corbin AS, Wardwell S, Ning Y, Keats JA, Wang Y, Sundaramoorthi R, Thomas M, Zhou D, Snodgrass J, Commodore L, Sawyer TK, Dalgarno DC, Deininger MW, Druker BJ, Clackson T: AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028. - Pubmed
DTHybrid score 0.5152

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • FDA label -
DTHybrid score 0.8472
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • FDA label -
DTHybrid score 0.4616
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • FDA label -
DTHybrid score 0.5457
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
  • FDA label -
DTHybrid score 0.4901

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • FDA label -
DTHybrid score 0.6859
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • FDA label -
DTHybrid score 0.5109
Bile salt export pump
Name Bile salt export pump
Gene Name ABCB11
Actions inhibitor
References
  • FDA label -
DTHybrid score 0.2719

Predictions


Id Partner name Gene Name Score
1585 Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 0.4019
4757 Cytochrome P450 2C9 CYP2C9 0.3754
3852 Neuropilin-1 NRP1 0.35
228 Beta platelet-derived growth factor receptor PDGFRB 0.3473
2599 Tyrosine-protein kinase HCK HCK 0.315
6016 Cytochrome P450 2C19 CYP2C19 0.301
4200 Cytochrome P450 1A2 CYP1A2 0.2799
6107 Cytochrome P450 3A7 CYP3A7 0.2661
26 Vascular endothelial growth factor receptor 3 FLT4 0.2638
32 Vascular endothelial growth factor receptor 1 FLT1 0.2563
6030 Cytochrome P450 2B6 CYP2B6 0.2052
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1707
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1698
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.1403
6024 Cytochrome P450 1A1 CYP1A1 0.1349
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.1256
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1254
6013 Cytochrome P450 2E1 CYP2E1 0.1251
862 Multidrug resistance-associated protein 1 ABCC1 0.1185
587 Serum albumin ALB 0.1159
936 Ephrin type-A receptor 2 EPHA2 0.1134
5798 Mitogen-activated protein kinase 11 MAPK11 0.1077
1618 High affinity nerve growth factor receptor NTRK1 0.0984
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0976
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0971
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0967
1128 Alpha-2-macroglobulin A2M 0.0966
2164 Multidrug resistance-associated protein 4 ABCC4 0.0954
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0937
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0931
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0898
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.083
844 Epidermal growth factor receptor EGFR 0.0828
5718 Cytochrome P450 2A6 CYP2A6 0.0773
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0771
20 Prostaglandin G/H synthase 1 PTGS1 0.0771
1898 Cytochrome P450 1B1 CYP1B1 0.0729
1144 Hepatocyte growth factor receptor MET 0.0692
6145 Solute carrier family 22 member 1 SLC22A1 0.068
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0631
6144 Solute carrier family 22 member 2 SLC22A2 0.0605
492 Histamine H1 receptor HRH1 0.0593
1729 Solute carrier family 22 member 6 SLC22A6 0.0557
760 Fibroblast growth factor 1 FGF1 0.0548
824 Sodium-dependent serotonin transporter SLC6A4 0.0532
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0529
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0508
2240 Cell division protein kinase 2 CDK2 0.0492
6142 Solute carrier family 22 member 8 SLC22A8 0.0486
6141 Sodium/bile acid cotransporter SLC10A1 0.0483
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0478
6106 Cytochrome P450 2C18 CYP2C18 0.047
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0462
831 D(2) dopamine receptor DRD2 0.0451
556 Alpha-1A adrenergic receptor ADRA1A 0.0449
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0433
502 5-hydroxytryptamine 2A receptor HTR2A 0.0424
871 Glucocorticoid receptor NR3C1 0.0421
3811 Cytochrome P450 19A1 CYP19A1 0.0404
290 Prostaglandin G/H synthase 2 PTGS2 0.0396
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.039
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0379
847 Mu-type opioid receptor OPRM1 0.0376
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0375
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0366
6148 Multidrug resistance-associated protein 7 ABCC10 0.0364
136 Estrogen receptor ESR1 0.0362
183 Vascular endothelial growth factor A VEGFA 0.0359
484 Tyrosine-protein kinase ABL2 ABL2 0.0352
320 5-hydroxytryptamine 1A receptor HTR1A 0.035
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0342
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0338
766 Beta-2 adrenergic receptor ADRB2 0.0337
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0337
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0336
1063 Signal transducer and activator of transcription 5B STAT5B 0.0329
6143 Solute carrier family 22 member 7 SLC22A7 0.032
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0316
118 Organic cation/carnitine transporter 2 SLC22A5 0.0313
193 Beta-1 adrenergic receptor ADRB1 0.0313
467 Delta-type opioid receptor OPRD1 0.0308
817 DNA topoisomerase 2-alpha TOP2A 0.0306
1864 RET proto-oncogene RET 0.0305
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0305
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0304
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0304
777 Tumor necrosis factor TNF 0.0293
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0292
632 Alpha-1B adrenergic receptor ADRA1B 0.029
6137 Multidrug resistance-associated protein 6 ABCC6 0.0289
731 HIV-1 protease HIV-1 protease 0.0289
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0284
6147 Solute carrier family 22 member 3 SLC22A3 0.0283
696 Kappa-type opioid receptor OPRK1 0.0283
6031 Cytochrome P450 3A43 CYP3A43 0.028
318 Alpha-2A adrenergic receptor ADRA2A 0.0277
6782 Ribosomal protein S6 kinase alpha-1 RPS6KA1 0.0273
713 Sodium-dependent dopamine transporter SLC6A3 0.0271
23 D(1A) dopamine receptor DRD1 0.0268
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0267
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0266
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0266
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0265
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0261
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0259
6182 Cytochrome P450 2J2 CYP2J2 0.0255
1024 Solute carrier family 22 member 11 SLC22A11 0.0251
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0245
590 5-hydroxytryptamine 2C receptor HTR2C 0.0242
468 Cytochrome P450 4A11 CYP4A11 0.0231
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0229
3923 Cholinesterase BCHE 0.0216
638 D(3) dopamine receptor DRD3 0.021
6460 Casein kinase I isoform gamma-3 CSNK1G3 0.0207
833 Organic cation/carnitine transporter 1 SLC22A4 0.0205
1353 DNA topoisomerase 1 TOP1 0.0205
3552 DNA topoisomerase 1 topA 0.0205
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0205
683 Potassium transporter GK0582 0.0203
465 Calmodulin CALM1 0.0201
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.02
4120 NADPH--cytochrome P450 reductase POR 0.02
341 5-hydroxytryptamine 3 receptor HTR3A 0.0199
161 Tubulin beta chain TUBB 0.0198
312 Tubulin beta chain TUB2 0.0198
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0198
260 Cytochrome P450 51 ERG11 0.0196
761 Cytochrome P450 51 ERG11 0.0196
3163 Cytochrome P450 51 cyp51 0.0196
29 Tubulin beta-1 chain TUBB1 0.0194
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0193
614 Progesterone receptor PGR 0.0193
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0192
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0191
885 5-hydroxytryptamine 1B receptor HTR1B 0.0191
4604 Liver carboxylesterase 1 CES1 0.0188
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0187
1540 Mitogen-activated protein kinase 14 MAPK14 0.0187
3941 Amine oxidase [flavin-containing] A MAOA 0.0183
238 Peroxisome proliferator-activated receptor gamma PPARG 0.018
789 Alpha-1D adrenergic receptor ADRA1D 0.0175
2473 Tyrosine-protein kinase CSK CSK 0.0174
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0173
725 5-hydroxytryptamine 1D receptor HTR1D 0.0169
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0169
380 Cytochrome P450 17A1 CYP17A1 0.0167
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0163
629 Alpha-2B adrenergic receptor ADRA2B 0.0161
2539 Tubulin alpha-1 chain TUBA4A 0.0158
869 Estrogen receptor beta ESR2 0.0157
737 Mineralocorticoid receptor NR3C2 0.0156
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0156
33 Cystine/glutamate transporter SLC7A11 0.0155
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0155
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0151
378 Alpha-2C adrenergic receptor ADRA2C 0.015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.015
232 Corticosteroid-binding globulin SERPINA6 0.015
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0148
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0146
2808 Chloramphenicol acetyltransferase 3 cat3 0.0145
131 Synaptic vesicular amine transporter SLC18A2 0.0144
146 Androgen receptor AR 0.0142
952 Dipeptidyl peptidase 4 DPP4 0.014
49 Endothelin B receptor EDNRB 0.0139
2530 Protein kinase C theta type PRKCQ 0.0139
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0138
6136 Multidrug resistance-associated protein 5 ABCC5 0.0137
738 Monocarboxylate transporter 1 SLC16A1 0.0136
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0136
756 Sex hormone-binding globulin SHBG 0.0136
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0136
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0135
70 Type-1 angiotensin II receptor AGTR1 0.0135
3947 Xanthine dehydrogenase/oxidase XDH 0.0134
4148 Serine/threonine-protein kinase mTOR MTOR 0.0134
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0134
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0134
432 D(4) dopamine receptor DRD4 0.0132
436 5-hydroxytryptamine 2B receptor HTR2B 0.0131
578 Endothelin-1 receptor EDNRA 0.0131
1721 Glycogen synthase kinase-3 beta GSK3B 0.013
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.013
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
124 Histamine H2 receptor HRH2 0.0127
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0126
474 Acetylcholinesterase ACHE 0.0126
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0125
4773 Deoxycytidine kinase DCK 0.0125
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0124
6220 Aryl hydrocarbon receptor AHR 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
2408 Tyrosine-protein kinase SYK SYK 0.0121
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0121
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.012
3939 Amine oxidase [flavin-containing] B MAOB 0.0119
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0119
3270 Elongation factor G fusA 0.0119
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
1852 Microtubule-associated protein 2 MAP2 0.0118
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0118
4609 U1 small nuclear ribonucleoprotein A SNRPA 0.0117
1192 Sulfotransferase 1A1 SULT1A1 0.0117
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0117
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0116
4192 DNA topoisomerase 2-beta TOP2B 0.0116
122 P2Y purinoceptor 12 P2RY12 0.0115
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0115
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0112
811 Translocator protein TSPO 0.0109
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
469 Annexin A1 ANXA1 0.0104
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0104
117 Sterol O-acyltransferase 1 SOAT1 0.0104
373 Transthyretin TTR 0.0103
1010 Cytochrome P450 51A1 CYP51A1 0.0102
4563 Acetyl transferase rimL 0.0102
2750 Aspartate 1-decarboxylase panD 0.0102
818 50S ribosomal protein L10 rplJ 0.0101
5923 Microtubule-associated protein tau MAPT 0.01
5924 Microtubule-associated protein 4 MAP4 0.01
716 5-hydroxytryptamine 7 receptor HTR7 0.01
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.01
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0099
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0097
273 Apoptosis regulator Bcl-2 BCL2 0.0097
2112 Toll-like receptor 9 TLR9 0.0097
2449 Tubulin alpha-3 chain TUBA1A 0.0095
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0095
1629 Transcription factor AP-1 JUN 0.0095
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0094
3490 Sigma factor sigB regulation protein rsbQ rsbQ 0.0094
5300 Antigen peptide transporter 1 TAP1 0.0094
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0091
768 FK506-binding protein 1A FKBP1A 0.0089
6167 Organic solute transporter subunit beta OSTB 0.0089
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0088
4600 Malonamidase E2 Not Available 0.0088
6166 Organic solute transporter subunit alpha OSTA 0.0088
6085 Fatty acid-binding protein, intestinal FABP2 0.0088
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0088
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0087
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0087
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0087
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0087
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0087
4608 Putative cytochrome P450 SCO1207 0.0087
4963 Putative cytochrome P450 SCO2884 0.0087
6254 Putative cytochrome P450 SCO6998 0.0087
340 Apoptotic protease-activating factor 1 APAF1 0.0086
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0086
163 D(1B) dopamine receptor DRD5 0.0085
3809 Estrogen-related receptor gamma ESRRG 0.0085
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0084
94 5-hydroxytryptamine 4 receptor HTR4 0.0084
239 Coagulation factor X F10 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0083
365 Dihydrofolate reductase DHFR 0.0083
2381 Dihydrofolate reductase DFR1 0.0083
2833 Dihydrofolate reductase Not Available 0.0083
2931 Dihydrofolate reductase folA 0.0083
3544 Dihydrofolate reductase folA 0.0083
3682 Dihydrofolate reductase folA 0.0083
6642 Dihydrofolate reductase folA 0.0083
6756 Dihydrofolate reductase dfrA 0.0083
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0082
904 Glutathione S-transferase P GSTP1 0.0081
6102 Arylamine N-acetyltransferase 2 NAT2 0.0081
1656 CYP2B protein CYP2B 0.0081
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0078
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0078
477 DNA topoisomerase 4 subunit A parC 0.0078
886 DNA topoisomerase 4 subunit A parC 0.0078
6226 DNA topoisomerase 4 subunit A parC 0.0078
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0078
2616 Ganglioside GM2 activator GM2A 0.0078
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0077
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0077
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0077
404 DNA gyrase subunit A gyrA 0.0077
6224 DNA gyrase subunit A gyrA 0.0077
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0077
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0077
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0077
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0077
4237 50S ribosomal protein L22 rplV 0.0076
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
992 Protein tyrosine kinase 2 beta PTK2B 0.0076
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0076
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0075
4203 Histamine N-methyltransferase HNMT 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
6020 Aldehyde oxidase AOX1 0.0074
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0074
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0073
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0073
908 Glutathione S-transferase theta-1 GSTT1 0.0072
705 Glutamate receptor 1 GRIA1 0.0072
1256 5-hydroxytryptamine 6 receptor HTR6 0.0072
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0072
68 Cannabinoid receptor 1 CNR1 0.0071
84 Nuclear receptor 0B1 NR0B1 0.007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.007
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0069
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0069
3086 Plasmepsin-2 Not Available 0.0068
1757 Myeloperoxidase MPO 0.0068
891 Dihydropteroate synthase folP 0.0067
5359 Dihydropteroate synthase folP 0.0067
7175 Dihydropteroate synthase sulI 0.0067
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0067
6211 Tubulin epsilon chain TUBE1 0.0067
6212 Tubulin gamma-1 chain TUBG1 0.0067
6210 Tubulin delta chain TUBD1 0.0067
2183 Fatty acid-binding protein, adipocyte FABP4 0.0066
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0066
1650 Heme carrier protein 1 SLC46A1 0.0066
208 DNA-directed RNA polymerase beta' chain rpoC 0.0065
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0065
1178 Adenosine A2a receptor ADORA2A 0.0065
24 Thymidylate synthase TMP1 0.0065
359 Thymidylate synthase TYMS 0.0065
2626 Thymidylate synthase thyA 0.0065
2729 Thymidylate synthase thyA 0.0065
5352 Thymidylate synthase THYA 0.0065
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0065
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0065
814 Ryanodine receptor 1 RYR1 0.0064
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0063
7 Nitric oxide synthase, inducible NOS2 0.0063
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0063
275 Arachidonate 5-lipoxygenase ALOX5 0.0063
4238 50S ribosomal protein L4 rplD 0.0063
5578 50S ribosomal protein L4 rplD 0.0063
6173 50S ribosomal protein L4 rplD 0.0063
6219 50S ribosomal protein L4 rplD 0.0063
3932 Glutathione S-transferase A2 GSTA2 0.0062
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0062
427 Substance-P receptor TACR1 0.0062
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0062
6146 High affinity copper uptake protein 1 SLC31A1 0.0062
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0062
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0061
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0061
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0061
5646 Galactokinase GALK1 0.0061
5302 TrwB trwB 0.0061
5265 FtsH ftsH 0.0061
292 Activin receptor type-1 ACVR1 0.0061
849 Activated CDC42 kinase 1 TNK2 0.0061
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0061
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0061
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0061
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0061
825 Arsenical pump-driving ATPase ASNA1 0.0061
3435 Arsenical pump-driving ATPase arsA 0.0061
733 Activin receptor type 1B ACVR1B 0.0061
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0061
395 ALK tyrosine kinase receptor Not Available 0.0061
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0061
284 DNA-directed RNA polymerase beta chain rpoB 0.0061
5773 DNA-directed RNA polymerase beta chain rpoB 0.0061
154 AFG3-like protein 2 AFG3L2 0.0061
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0061
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0061
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0061
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0061
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0061
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6014 Cytochrome P450 2A13 CYP2A13 0.0059
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0058
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0058
1050 Bile salt sulfotransferase SULT2A1 0.0058
528 5-hydroxytryptamine 1E receptor HTR1E 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0057
6138 Multidrug resistance protein 3 ABCB4 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
4210 Toll-like receptor 4 TLR4 0.0057
319 Opioid receptor, sigma 1 OPRS1 0.0056
5312 Kinesin-like protein KIF1A KIF1A 0.0056
3587 Gastrotropin FABP6 0.0055
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0055
6506 Stathmin-4 STMN4 0.0055
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0054
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0054
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0053
4311 tRNA TRDMT1 0.0053
4325 tRNA trmD 0.0053
4328 tRNA trmD 0.0053
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0053
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0053
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0053
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0053
297 Adenylate cyclase type 1 ADCY1 0.0053
2615 Chemotaxis protein cheA cheA 0.0052
2371 Pantothenate kinase coaA 0.0052
2892 Acetylglutamate kinase argB 0.0052
3550 Acetylglutamate kinase argB 0.0052
1881 Hexokinase-1 HK1 0.0052
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0052
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0052
88 Retinoic acid receptor RXR-beta RXRB 0.0051
6755 Poliovirus receptor PVR 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
661 ADP/ATP translocase 1 SLC25A4 0.005
511 5-hydroxytryptamine 1F receptor HTR1F 0.005
2727 S-adenosylmethionine synthetase metK 0.005
1541 Metalloproteinase mmp20 0.0049
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0049
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0049
295 Carbonic anhydrase 1 CA1 0.0048
856 Vitamin D3 receptor VDR 0.0048
5934 Cytochrome P450 26A1 CYP26A1 0.0048
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0048
16 Adenosine A1 receptor ADORA1 0.0048
4122 Histone deacetylase 2 HDAC2 0.0048
6174 50S ribosomal protein L32 rpmF 0.0047
1517 Beta-3 adrenergic receptor ADRB3 0.0047
174 Sigma 1-type opioid receptor SIGMAR1 0.0047
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0047
6021 Adenosine kinase ADK 0.0047
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0046
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
3810 Catechol O-methyltransferase COMT 0.0046
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0046
5643 General secretion pathway protein E epsE 0.0046
5641 Rod shape-determining protein MreB TM_0588 0.0046
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0046
5649 Potassium-transporting ATPase B chain kdpB 0.0046
3794 Osmolarity sensor protein envZ envZ 0.0046
5644 Sensor protein phoQ phoQ 0.0046
5642 Chaperone clpB clpB 0.0046
5645 DNA topoisomerase 4 subunit B parE 0.0046
6227 DNA topoisomerase 4 subunit B parE 0.0046
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0045
6228 Nuclear receptor coactivator 1 NCOA1 0.0045
6163 Copper-transporting ATPase 2 ATP7B 0.0045
6165 Copper-transporting ATPase 1 ATP7A 0.0045
896 Glutathione S-transferase Mu 1 GSTM1 0.0045
2852 DNA mismatch repair protein mutL mutL 0.0045
54 Prothrombin F2 0.0045
1483 Membrane copper amine oxidase AOC3 0.0045
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0044
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0044
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0044
267 Plasminogen activator inhibitor 1 SERPINE1 0.0044
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0044
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0044
702 UMP-CMP kinase CMPK1 0.0044
740 Argininosuccinate synthase ASS1 0.0044
865 Argininosuccinate synthase ASS1 0.0044
2680 Argininosuccinate synthase argG 0.0044
3194 Argininosuccinate synthase argG 0.0044
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0044
106 Cannabinoid receptor 2 CNR2 0.0044
4103 Proteasome subunit beta type 2 PSMB2 0.0044
4102 Proteasome subunit beta type 5 PSMB5 0.0044
4101 Proteasome subunit beta type 1 PSMB1 0.0044
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
2251 Thymidylate kinase tmk 0.0042
2254 Thymidylate kinase DTYMK 0.0042
3522 Thymidylate kinase tmk 0.0042
3917 Methylenetetrahydrofolate reductase MTHFR 0.0042
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0042
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
162 Retinoic acid receptor gamma-1 RARG 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
921 Glutamate receptor 2 GRIA2 0.0041
394 Calcineurin subunit B isoform 1 PPP3R1 0.0041
6753 Apolipoprotein M APOM 0.0041
6742 Recoverin RCVRN 0.0041
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0041
6747 Chalcone/stilbene synthase family protein MT1417 0.0041
6743 Non-fluorescent flavoprotein luxF 0.0041
2528 Fatty acid metabolism regulator protein fadR 0.0041
6740 Fatty acid metabolism regulator protein fadR 0.0041
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0041
6751 Gag polyprotein gag 0.0041
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0041
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0041
6749 Polyprotein Not Available 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.004
4751 Mitogen-activated protein kinase 12 MAPK12 0.004
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.004
751 Potassium channel subfamily K member 6 KCNK6 0.004
2397 Dihydroxyacetone kinase dhaK 0.004
3822 Actin, alpha skeletal muscle ACTA1 0.004
2297 Genome polyprotein Not Available 0.004
2322 Genome polyprotein Not Available 0.004
2694 Genome polyprotein Not Available 0.004
2719 Genome polyprotein Not Available 0.004
2860 Genome polyprotein Not Available 0.004
2928 Genome polyprotein Not Available 0.004
3160 Genome polyprotein Not Available 0.004
3260 Genome polyprotein Not Available 0.004
4783 Genome polyprotein Not Available 0.004
5726 Genome polyprotein Not Available 0.004
5779 Genome polyprotein Not Available 0.004
5867 Genome polyprotein Not Available 0.004
6253 Genome polyprotein Not Available 0.004
6301 Genome polyprotein Not Available 0.004
6380 Genome polyprotein Not Available 0.004
6381 Genome polyprotein Not Available 0.004
6437 Genome polyprotein Not Available 0.004
6520 Genome polyprotein Not Available 0.004
6521 Genome polyprotein Not Available 0.004
6652 Genome polyprotein Not Available 0.004
6734 Genome polyprotein Not Available 0.004
6735 Genome polyprotein Not Available 0.004
6736 Genome polyprotein Not Available 0.004
6737 Genome polyprotein Not Available 0.004
6738 Genome polyprotein Not Available 0.004
6739 Genome polyprotein Not Available 0.004
6744 Genome polyprotein Not Available 0.004
6748 Genome polyprotein Not Available 0.004
6894 Genome polyprotein Not Available 0.004
6898 Genome polyprotein Not Available 0.004
6221 Steroid hormone receptor ERR1 ESRRA 0.004
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.004
207 Glutathione synthetase GSS 0.004
5269 Glutathione synthetase gshB 0.004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0039
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0039
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0039
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0039
6168 Solute carrier family 22 member 16 SLC22A16 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
592 Carbonic anhydrase 4 CA4 0.0038
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0038
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
1630 Integrin beta-2 ITGB2 0.0037
3231 Death-associated protein kinase 1 DAPK1 0.0037
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0037
976 Platelet glycoprotein IX GP9 0.0037
172 Potassium channel subfamily K member 1 KCNK1 0.0037
4217 Telomerase reverse transcriptase TERT 0.0036
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0036
1196 Complement decay-accelerating factor CD55 0.0036
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0036
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0036
5961 Insulin INS 0.0036
6527 Lymphocyte antigen 96 LY96 0.0036
153 Dopamine beta-hydroxylase DBH 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
4116 Dihydropteroate synthetase Not Available 0.0035
1262 Corticotropin-lipotropin POMC 0.0035
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
939 50S ribosomal protein L3 rplC 0.0035
293 Gamma-glutamyl hydrolase GGH 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0034
6149 Solute carrier family 22 member 10 SLC22A10 0.0034
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0034
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
6750 ADP-ribosylation factor 6 ARF6 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
581 Cytochrome P450 2R1 CYP2R1 0.0033
518 Peroxidase/catalase T katG 0.0033
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0033
887 DNA gyrase subunit B gyrB 0.0033
4150 DNA gyrase subunit B gyrB 0.0033
6225 DNA gyrase subunit B gyrB 0.0033
6524 Protein tonB tonB 0.0033
5880 Thrombopoietin receptor MPL 0.0033
6432 Transporter snf 0.0033
780 Retinoic acid receptor RXR-gamma RXRG 0.0033
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
6048 Troponin C, skeletal muscle TNNC2 0.0032
229 Retinoic acid receptor beta RARB 0.0032
6316 ADP-ribosylation factor 1 ARF1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0031
1648 Elastin ELN 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
958 Insulin-like growth factor 1 receptor IGF1R 0.003
6044 Serum paraoxonase/lactonase 3 PON3 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
291 Nitric-oxide synthase, endothelial NOS3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.003
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.003
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0029
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0029
489 Monocarboxylate transporter 2 SLC16A7 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0029
2236 Casein kinase II subunit alpha CSNK2A1 0.0029
2320 Thymidine kinase, cytosolic TK1 0.0029
5294 Nucleoside diphosphate kinase A NME1 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
2417 Chloramphenicol acetyltransferase cat 0.0029
3278 Chloramphenicol acetyltransferase cat 0.0029
3601 Dihydropteroate synthase 1 folP1 0.0029
3807 Dihydropteroate synthase 1 folP1 0.0029
3808 Dihydropteroate synthase 2 folP2 0.0029
233 Potassium channel subfamily K member 2 KCNK2 0.0029
2810 Dr hemagglutinin structural subunit draA 0.0029
1525 Heparin-binding growth factor 2 FGF2 0.0028
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
572 Integrin alpha-L ITGAL 0.0028
76 Nitric-oxide synthase, brain NOS1 0.0028
634 Squalene monooxygenase SQLE 0.0028
7196 Squalene monooxygenase ERG1 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3913 Glutamic acid decarboxylase GAD65 0.0027
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
864 Gag-Pol polyprotein gag-pol 0.0026
2237 Gag-Pol polyprotein gag-pol 0.0026
2326 Gag-Pol polyprotein gag-pol 0.0026
2451 Gag-Pol polyprotein gag-pol 0.0026
2901 Gag-Pol polyprotein gag-pol 0.0026
3165 Gag-Pol polyprotein gag-pol 0.0026
3722 Gag-Pol polyprotein gag-pol 0.0026
6306 Gag-Pol polyprotein gag-pol 0.0026
6624 Gag-Pol polyprotein gag-pol 0.0026
1836 Mitogen-activated protein kinase 10 MAPK10 0.0026
4226 Uridine phosphorylase 2 UPP2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
605 Fumarate reductase flavoprotein subunit frdA 0.0026
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0026
3673 Fumarate reductase flavoprotein subunit fccA 0.0026
4912 Fumarate reductase flavoprotein subunit ifcA 0.0026
6549 Fumarate reductase flavoprotein subunit frdA 0.0026
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0026
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0026
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0026
5304 UPF0166 protein TM_0021 TM_0021 0.0025
5293 Shikimate kinase 2 aroL 0.0025
5266 Activator of hgdC 0.0025
5287 Signaling protein Not Available 0.0025
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0025
5292 Putative partitioning protein TT_C1605 0.0025
3199 Phosphopantetheine adenylyltransferase coaD 0.0025
3543 Phosphopantetheine adenylyltransferase coaD 0.0025
3567 Phosphopantetheine adenylyltransferase coaD 0.0025
5289 Phosphopantetheine adenylyltransferase coaD 0.0025
5281 Plasmid segregation protein parM parM 0.0025
2874 Nitrogenase iron protein 1 nifH1 0.0025
4346 Polynucleotide kinase pseT 0.0025
5283 D-alanine--D-alanine ligase B ddlB 0.0025
5288 Shikimate kinase aroK 0.0025
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0025
5299 D-alanine--D-alanine ligase ddl 0.0025
6598 D-alanine--D-alanine ligase ddl 0.0025
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0025
5276 Chromosomal replication initiator protein dnaA dnaA 0.0025
5315 Chaperone protein htpG htpG 0.0025
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0025
5259 Transcriptional regulator ntrC1 0.0025
6699 Transcriptional regulator Cgl2612 0.0025
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5284 Large T antigen Not Available 0.0025
5291 Glycogen synthase 1 glgA1 0.0025
5264 DNA replication protein REP 0.0025
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0025
5285 Kinesin heavy chain KIF5B 0.0025
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0025
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0025
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0025
5261 Phosphoribosylformylglycinamidine synthase purL 0.0025
5277 Preprotein translocase subunit secA secA 0.0025
5308 Preprotein translocase secA 1 subunit secA1 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
6103 Arylamine N-acetyltransferase 1 NAT1 0.0025
2697 Uridine-cytidine kinase 2 UCK2 0.0024
4225 Uridine phosphorylase 1 UPP1 0.0024
2391 Ferrochelatase hemH 0.0024
6502 Ferrochelatase DKFZp686P18130 0.0024
1591 Ferrochelatase, mitochondrial FECH 0.0024
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
164 Histamine H4 receptor HRH4 0.0024
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2427 Ferrichrome-iron receptor fhuA 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
735 Alanine aminotransferase 1 GPT 0.0023
3904 Alanine aminotransferase 2 GPT2 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0022
2515 Amidophosphoribosyltransferase purF 0.0022
3714 Amidophosphoribosyltransferase purF 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0022
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0022
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2091 Endoplasmin HSP90B1 0.0022
1992 Vitamin D-binding protein GC 0.0022
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0022
298 Renin REN 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.0021
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0021
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0021
6493 Cytochrome c oxidase subunit 6C COX6C 0.0021
3957 Adenosine deaminase ADA 0.0021
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0021
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0021
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0021
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0021
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0021
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0021
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0021
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0021
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0021
6559 Cytochrome c oxidase subunit 2 ctaC 0.0021
6669 Cytochrome c oxidase subunit 2 ctaC 0.0021
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0021
6558 Cytochrome c oxidase subunit 1 ctaD 0.0021
3470 Hypothetical protein MG245 homolog MPN_348 0.0021
6277 Heat shock cognate 71 kDa protein HSPA8 0.0021
5189 Trimethylamine dehydrogenase tmd 0.002
4106 Guanylate kinase GUK1 0.002
4516 Guanylate kinase gmk 0.002
4837 Cag-alfa cag-alfa 0.002
4774 NTPase P4 Not Available 0.002
4839 DNA polymerase III subunit tau dnaX 0.002
4838 PMS1 protein homolog 2 PMS2 0.002
719 Retinoic acid receptor responder protein 1 RARRES1 0.002
2270 Dephospho-CoA kinase coaE 0.002
770 Retinoic acid-induced protein 3 GPRC5A 0.002
2284 Adenylate kinase adk 0.002
2296 Adenylate kinase adk 0.002
2311 Adenylate kinase adk 0.002
2312 Adenylate kinase Not Available 0.002
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.002
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
3426 Glutamine synthetase glnA 0.002
3987 Glutamine synthetase GLUL 0.002
3175 Glutamate--cysteine ligase gshA 0.002
5626 Nucleoside diphosphate kinase B NME2 0.002
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.002
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.002
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.002
6126 Carbonic anhydrase 7 CA7 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
482 Glycine receptor subunit alpha-1 GLRA1 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0019
2683 Mono-ADP-ribosyltransferase C3 C3 0.0019
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
2540 Choloylglycine hydrolase cbh 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1275 Estrogen sulfotransferase SULT1E1 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
65 Matrix metalloproteinase-9 Not Available 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
5271 Focal adhesion kinase 1 PTK2 0.0018
2390 Nonsecretory ribonuclease RNASE2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
2922 Glycerol kinase glpK 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
569 Retinal dehydrogenase 2 ALDH1A2 0.0018
6501 Fatty acid-binding protein, liver FABP1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
2207 Rhodopsin RHO 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0017
408 Riboflavin kinase RFK 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
2282 Protein recA recA 0.0017
2315 Protein recA recA 0.0017
2332 Protein recA recA 0.0017
5263 Protein recA recA 0.0017
3669 Ribokinase rbsK 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
611 Retinal dehydrogenase 1 ALDH1A1 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
6151 Monocarboxylate transporter 10 SLC16A10 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
3937 Fatty-acid amide hydrolase FAAH 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
788 Creatine kinase M-type CKM 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
1039 Histone deacetylase 9 HDAC9 0.0016
1123 Eosinophil cationic protein RNASE3 0.0016
3233 Bile acid receptor NR1H4 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
2334 Dethiobiotin synthetase bioD 0.0015
6555 Dethiobiotin synthetase bioD 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6677 Myelin P2 protein PMP2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
563 Thyroid peroxidase TPO 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
6500 Phospholipase A2 PLA2G1B 0.0015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
48 Pyridoxal kinase PDXK 0.0015
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0014
6395 Myosin-14 MYH14 0.0014
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0014
5818 Folate receptor alpha FOLR1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1341 Histamine H3 receptor HRH3 0.0014
1422 Serine/threonine-protein kinase 6 AURKA 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
4992 Cytochrome c peroxidase Not Available 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
6218 Pannexin-1 PANX1 0.0013
3379 Kinesin-like protein KIF11 KIF11 0.0013
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
2021 Thrombomodulin THBD 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0013
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0013
5591 Complement component C8 gamma chain C8G 0.0013
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0013
5582 Regulator of transcription; stringent starvation protein A sspA 0.0013
2838 Ribose-5-phosphate isomerase A rpiA 0.0013
2952 Ribose-5-phosphate isomerase A rpiA 0.0013
5595 Ribose-5-phosphate isomerase A rpiA 0.0013
4695 UPF0124 protein yfiH yfiH 0.0013
5590 N utilization substance protein B homolog nusB 0.0013
5588 Cell division protein FtsY TM_0570 0.0013
4375 Glutamine synthetase 1 glnA1 0.0013
5587 Iron(III)-binding periplasmic protein fbpA 0.0013
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0013
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0013
5593 Transferase Not Available 0.0013
5581 Beta-fructosidase bfrA 0.0013
5060 Intron-associated endonuclease 1 ITEVIR 0.0013
5575 Short tail fiber protein 12 0.0013
5600 Pyruvate decarboxylase pdc 0.0013
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0013
5580 Hexon protein PII 0.0013
5574 Invasin YPTB1668 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
509 Thymidine kinase TK 0.0012
570 Thymidine kinase TK 0.0012
2559 Thymidine kinase TK 0.0012
3430 Thymidine kinase tdk 0.0012
3518 Thymidine kinase TK 0.0012
5301 Thymidine kinase tdk 0.0012
5771 Thymidine kinase ORF36 0.0012
7009 Thymidine kinase ORF36 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0011
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5006 RNASE4 protein RNASE4 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
2981 Phospholipase A2, membrane associated PLA2G2A 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.001
2603 Beta-lactamase II blm 0.001
3583 6-phosphogluconolactonase pgl 0.001
2149 Angiogenin ANG 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.001
2286 Isocitrate dehydrogenase [NADP] icd 0.001
2302 Isocitrate dehydrogenase [NADP] icd 0.001
2771 Isocitrate dehydrogenase [NADP] icd 0.001
3486 Fumarate hydratase class II fumC 0.001
2942 Sialidase nanH 0.001
3546 Sialidase nedA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
857 Malate dehydrogenase, mitochondrial MDH2 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
332 Beta-lactamase blaZ 0.0009
2478 Beta-lactamase ampC 0.0009
2613 Beta-lactamase ampC 0.0009
2635 Beta-lactamase ampC 0.0009
2700 Beta-lactamase penP 0.0009
5445 Beta-lactamase blaB 0.0009
6019 Beta-lactamase SHV-7 0.0009
6701 Beta-lactamase cphA 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
5579 Carboxypeptidase B CPB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
411 Glycine N-methyltransferase GNMT 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2298 Cytochrome P450-cam camC 0.0008
1025 Aquaporin-1 AQP1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
130 Prostacyclin synthase PTGIS 0.0007
128 Adenine phosphoribosyltransferase APRT 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
125 DNA polymerase beta POLB 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
3221 Cytochrome c4 cc4 0.0006
822 Aldose reductase AKR1B1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
4692 A/G-specific adenine glycosylase mutY 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
2802 Endoglucanase G celCCG 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4943 Cytochrome c6 petJ 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4961 Hemophore HasA hasA 0.0003
4909 CooA protein cooA 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4984 Neuroglobin NGB 0.0003
5000 HemO hemO 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4910 Cytoglobin CYGB 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4972 P450cin cinA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4952 Catalase/peroxidase katA 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4990 PpcA ppcA 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
358 Cystathionine beta-synthase CBS 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
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