DT-Web: DB00220

Identification

Name

Nelfinavir

Accession Number

DB00220 (APRD00003)

Type

small molecule

Description

A potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

567.782

Groups

approved

Monoisotopic Weight

567.313077633

Pharmacology

Indication

Used in combination with other antiviral drugs in the treatment of HIV in both adults and children.

Mechanism of action

Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.

Absorption

Well absorbed following oral administration.

Protein binding

>98%

Biotransformation

Primarily hepatic via cytochrome P450 (CYP450) enzymes. CYP3A and CYP2C19 appear to be the predominant enzymes that metabolize nelfinavir in humans. One major and several minor metabolites are found in plasma; the major oxidative metabolite has in vitro antiviral activity comparable to that of the parent drug.

Route of elimination

The terminal half-life in plasma was typically 3.5 to 5 hours. The majority (87%) of an oral 750 mg dose containing 14C-nelfinavir was recovered in the feces; fecal radioactivity consisted of numerous oxidative metabolites (78%) and unchanged nelfinavir (22%). Only 1-2% of the dose was recovered in urine, of which unchanged nelfinavir was the major component.

Toxicity

Oral LD₅₀ is over 5g/kg in rats. Side effects include thirst and hunger, unexplained weight loss, increased urination, fatigue, and dry, itchy skin.

Affected organisms

Human Immunodeficiency Virus

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abacavir	The serum concentration of Abacavir may be decreased by protease inhibitors such as Nelfinavir. The antiviral response should be closely monitored.
Abiraterone	Strong CYP3A4 inhibitors may increase levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol	The protease inhibitor, nelfinavir, may increase the anticoagulant effect of acenocoumarol.
Alprazolam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, alprazolam.
Amiodarone	Nelfinavir may increase the effect and toxicity of amiodarone.
Anisindione	The protease inhibitor, nelfinavir, may increase the anticoagulant effect of anisindione.
Aprepitant	This CYP3A4 inhibitor increases the effect and toxicity of aprepitant
Astemizole	Increased risk of cardiotoxicity and arrhythmias
Atorvastatin	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of atorvastatin by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of atorvastatin if nelfinavir is initiated, discontinued or dose changed.
Bromazepam	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if nelfinavir is initiated, discontinued or dose changed. Dosage adjustments may be required.
Cabazitaxel	Concomitant therapy with a strong CYP3A4 inhibitor may increase concentrations of cabazitaxel. Avoid concomitant therapy.
Chlordiazepoxide	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, chlordiazepoxide.
Ciclesonide	Increased effects/toxicity of ciclesonide
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Clonazepam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, clonazepam.
Clorazepate	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, clorazepate.
Cyclosporine	The protease inhibitor, nelfinavir, may increase the effect of cyclosporine.
Dantrolene	Nelfinavir may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if nelfinavir is initiated, discontinued or dose changed.
Darifenacin	Nelfinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of darifenacin/solifenacin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of darifenacin if nelfinavir is initiated, discontinued or dose changed.
Diazepam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, diazepam.
Dicumarol	The protease inhibitor, nelfinavir, may increase the anticoagulant effect of dicumarol.
Dihydroergotamine	Nelfinavir increases the effect and toxicity of ergot derivative
Dihydroquinidine barbiturate	Nelfinavir increases the effect and toxicity of quindine
Eletriptan	The protease inhibitor, nelfinavir, may increase the effect and toxicity of eletriptan.
Eplerenone	The protease inhibitor, nelfinavir, may increase the effect and toxicity of eplerenone.
Ergotamine	Nelfinavir increases the effect and toxicity of ergot derivative
Erlotinib	This CYP3A4 inhibitor increases levels/toxicity of erlotinib
Estazolam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, estazolam.
Ethinyl Estradiol	Ritonavir could decrease the contraceptive efficacy
Felodipine	Nelfinavir increases the effect and toxicity of felodipine
Fentanyl	The protease inhibitor, nelfinavir, may increase the effect and toxicity of fentanyl.
Flurazepam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, flurazepam.
Fusidic Acid	The protease inhibitor, nelfinavir, may increase the effect and toxicity of fusidic acid.
Halazepam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, halazepam.
Lovastatin	Nelfinavir may increase the effect and toxicity of lovastatin. Concomitant therapy is contraindicated.
Mestranol	Ritonavir could decrease the contraceptive efficacy
Methadone	Nelfinavir decreases the effect of methadone
Midazolam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, midazolam.
Nevirapine	Nevirapine may decrease the effect of nelfinavir.
Pimozide	Nelfinavir increases the effect and toxicity of pimozide
Ponatinib	Strong CYP3A4 inhibitors may increase levels of ponatinib. Monitor concomitant therapy closely.
Prazepam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, prazepam.
Quazepam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, quazepam.
Quinidine	Nelfinavir increases the effect and toxicity of quinidine
Quinidine barbiturate	Nelfinavir increases the effect and toxicity of quinidine
Ranolazine	Increased levels of ranolazine - risk of toxicity
Rifampin	Rifampin decreases the effect of nelfinavir
Saxagliptin	Nelfinavir is an inhibitor of CYP3A4 which increases exposure of saxagliptin. Decrease dose of saxagliptin to 2.5 mg per day.
Sildenafil	The protease inhibitor, nelfinavir, may increase the effect and toxicity of sildenafil.
Simvastatin	Nelfinavir may increase the effect and toxicity of simvastatin. Concomitant therapy should be avoided.
Solifenacin	This potent CYP3A4 inhibitor slows darifenacin / solifenacin metabolism
St. John's Wort	St. John's Wort decreases the effect of indinavir
Sunitinib	Possible increase in sunitinib levels
Tacrolimus	The protease inhibitor, Nelfinavir, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Nelfinavir therapy is initiated, discontinued or altered.
Tadalafil	Nelfinavir may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen	Nelfinavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen.
Tamsulosin	Nelfinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Nelfinavir is initiated, discontinued, or dose changed.
Telaprevir	Telaprevir increases levels by affecting CYP3A4 metabolism. Concomitant therapy is contraindicated.
Telithromycin	Nelfinavir may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus	Nelfinavir may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide	The strong CYP3A4 inhibitor, Nelfinavir, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Nelfinavir is initiated, discontinued or dose changed.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Tiagabine	The strong CYP3A4 inhibitor, Nelfinavir, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Nelfinavir is initiated, discontinued or dose changed.
Tolterodine	Nelfinavir may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Topotecan	The p-glycoprotein inhibitor, Nelfinavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tramadol	Nelfinavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance.
Trazodone	The protease inhibitor, Nelfinavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Nelfinavir is initiated, discontinued or dose changed.
Triazolam	The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, triazolam.
Trimipramine	The strong CYP3A4 inhibitor, Nelfinavir, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Nelfinavir is initiated, discontinued or dose changed.
Vardenafil	Nelfinavir, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Vemurafenib	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Venlafaxine	Nelfinavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Nelfinavir is initiated, discontinued, or dose changed.
Verapamil	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Nelfinavir is initiated, discontinued or dose changed.
Vinblastine	Nelfinavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Nelfinavir is initiated, discontinued or dose changed.
Vincristine	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Nelfinavir is initiated, discontinued or dose changed.
Vinorelbine	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Nelfinavir is initiated, discontinued or dose changed.
Voriconazole	Nelfinavir may decrease the serum concentration of voriconazole likely by increasing its metabolism. Voriconazole may increase the serum concentration of nelfinavir by decreasing its metabolism. Consider alternate therapy or adjust doses and monitor for reduced voriconazole efficacy and increased nelfinavir adverse effects during concomitant therapy.
Warfarin	The protease inhibitor, nelfinavir, may increase the anticoagulant effect of warfarin.
Zolpidem	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if nelfinavir is initiated, discontinued or dose changed.
Zonisamide	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if nelfinavir is initiated, discontinued or dose changed.
Zopiclone	Nelfinavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if nelfinavir is initiated, discontinued or dose changed.

Food Interactions

Take with food.
Food significantly increases absorption (2 to 3 times).

HIV-1 protease
Name	HIV-1 protease
Gene Name	HIV-1 protease
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Garriga C, Perez-Elias MJ, Delgado R, Ruiz L, Najera R, Pumarola T, Alonso-Socas Mdel M, Garcia-Bujalance S, Menendez-Arias L: Mutational patterns and correlated amino acid substitutions in the HIV-1 protease after virological failure to nelfinavir- and lopinavir/ritonavir-based treatments. J Med Virol. 2007 Nov;79(11):1617-28. - Pubmed Wittayanarakul K, Hannongbua S, Feig M: Accurate prediction of protonation state as a prerequisite for reliable MM-PB(GB)SA binding free energy calculations of HIV-1 protease inhibitors. J Comput Chem. 2007 Sep 11;. - Pubmed Dandache S, Sevigny G, Yelle J, Stranix BR, Parkin N, Schapiro JM, Wainberg MA, Wu JJ: In Vitro Antiviral Activity and Cross-Resistance Profile of PL-100, a Next Generation Protease Inhibitor of Human Immunodeficiency Virus Type 1. Antimicrob Agents Chemother. 2007 Jul 16;. - Pubmed Perez MA, Fernandes PA, Ramos MJ: Drug design: new inhibitors for HIV-1 protease based on Nelfinavir as lead. J Mol Graph Model. 2007 Oct;26(3):634-42. Epub 2007 Mar 24. - Pubmed Velazquez-Campoy A, Kiso Y, Freire E: The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design. Arch Biochem Biophys. 2001 Jun 15;390(2):169-75. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.3591

Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inhibitor
References	Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ: Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion. Drug Metab Dispos. 2001 Feb;29(2):100-2. - Pubmed Tanabe M, Hashimoto M, Ono H: Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. Eur J Pharmacol. 2008 Jul 28;589(1-3):102-5. Epub 2008 Jun 7. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4339
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6267
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.0578
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4384
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate,inhibitor
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.57
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5928
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6718
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7026

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor,inducer
References	Perloff MD, von Moltke LL, Fahey JM, Daily JP, Greenblatt DJ: Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture. AIDS. 2000 Jun 16;14(9):1287-9. - Pubmed Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. - Pubmed Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. - Pubmed Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998 Jan 15;101(2):289-94. - Pubmed
DTHybrid score	0.7032
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM: Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos. 2000 Mar;28(3):329-34. - Pubmed
DTHybrid score	0.2971
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	inhibitor
References	Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. - Pubmed
DTHybrid score	0.3057
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	Gupta A, Zhang Y, Unadkat JD, Mao Q: HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2). J Pharmacol Exp Ther. 2004 Jul;310(1):334-41. Epub 2004 Mar 8. - Pubmed
DTHybrid score	0.3422
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Tirona RG, Leake BF, Wolkoff AW, Kim RB: Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation. J Pharmacol Exp Ther. 2003 Jan;304(1):223-8. - Pubmed
DTHybrid score	0.3332

Id	Partner name	Gene Name	Score
4924	Cytochrome P450 2C8	CYP2C8	0.4172
6013	Cytochrome P450 2E1	CYP2E1	0.2275
6024	Cytochrome P450 1A1	CYP1A1	0.2007
587	Serum albumin	ALB	0.1912
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1902
862	Multidrug resistance-associated protein 1	ABCC1	0.1768
5718	Cytochrome P450 2A6	CYP2A6	0.1529
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1433
6144	Solute carrier family 22 member 2	SLC22A2	0.1323
20	Prostaglandin G/H synthase 1	PTGS1	0.1219
492	Histamine H1 receptor	HRH1	0.1108
1729	Solute carrier family 22 member 6	SLC22A6	0.1103
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1098
776	Bile salt export pump	ABCB11	0.0994
6142	Solute carrier family 22 member 8	SLC22A8	0.0953
824	Sodium-dependent serotonin transporter	SLC6A4	0.0948
6106	Cytochrome P450 2C18	CYP2C18	0.0946
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0942
118	Organic cation/carnitine transporter 2	SLC22A5	0.0846
831	D(2) dopamine receptor	DRD2	0.0825
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0823
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0804
556	Alpha-1A adrenergic receptor	ADRA1A	0.0792
1898	Cytochrome P450 1B1	CYP1B1	0.0788
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0773
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0736
3811	Cytochrome P450 19A1	CYP19A1	0.072
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0712
6143	Solute carrier family 22 member 7	SLC22A7	0.0693
6147	Solute carrier family 22 member 3	SLC22A3	0.0688
2164	Multidrug resistance-associated protein 4	ABCC4	0.0676
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.067
320	5-hydroxytryptamine 1A receptor	HTR1A	0.065
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0637
833	Organic cation/carnitine transporter 1	SLC22A4	0.0624
847	Mu-type opioid receptor	OPRM1	0.0613
136	Estrogen receptor	ESR1	0.0604
290	Prostaglandin G/H synthase 2	PTGS2	0.0599
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0576
766	Beta-2 adrenergic receptor	ADRB2	0.0574
318	Alpha-2A adrenergic receptor	ADRA2A	0.0572
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0567
6141	Sodium/bile acid cotransporter	SLC10A1	0.0564
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0561
103	Muscarinic acetylcholine receptor M1	CHRM1	0.056
23	D(1A) dopamine receptor	DRD1	0.0548
713	Sodium-dependent dopamine transporter	SLC6A3	0.0545
632	Alpha-1B adrenergic receptor	ADRA1B	0.0529
871	Glucocorticoid receptor	NR3C1	0.0529
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0518
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0515
193	Beta-1 adrenergic receptor	ADRB1	0.0504
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0503
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0503
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0502
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0497
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0482
6031	Cytochrome P450 3A43	CYP3A43	0.0482
3941	Amine oxidase [flavin-containing] A	MAOA	0.0478
467	Delta-type opioid receptor	OPRD1	0.0469
6148	Multidrug resistance-associated protein 7	ABCC10	0.0462
590	5-hydroxytryptamine 2C receptor	HTR2C	0.046
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0452
817	DNA topoisomerase 2-alpha	TOP2A	0.0451
1024	Solute carrier family 22 member 11	SLC22A11	0.0442
696	Kappa-type opioid receptor	OPRK1	0.044
468	Cytochrome P450 4A11	CYP4A11	0.0412
3923	Cholinesterase	BCHE	0.0412
260	Cytochrome P450 51	ERG11	0.041
761	Cytochrome P450 51	ERG11	0.041
3163	Cytochrome P450 51	cyp51	0.041
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0399
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0382
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0376
638	D(3) dopamine receptor	DRD3	0.0375
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.037
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0368
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0367
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0366
465	Calmodulin	CALM1	0.0362
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0361
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0359
756	Sex hormone-binding globulin	SHBG	0.0355
33	Cystine/glutamate transporter	SLC7A11	0.035
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0349
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0348
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0344
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0344
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0341
844	Epidermal growth factor receptor	EGFR	0.034
504	Mast/stem cell growth factor receptor	KIT	0.0339
789	Alpha-1D adrenergic receptor	ADRA1D	0.0336
629	Alpha-2B adrenergic receptor	ADRA2B	0.0336
3939	Amine oxidase [flavin-containing] B	MAOB	0.033
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0329
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0327
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0325
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0321
6182	Cytochrome P450 2J2	CYP2J2	0.032
378	Alpha-2C adrenergic receptor	ADRA2C	0.0319
70	Type-1 angiotensin II receptor	AGTR1	0.0319
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0314
6137	Multidrug resistance-associated protein 6	ABCC6	0.0311
4604	Liver carboxylesterase 1	CES1	0.0297
146	Androgen receptor	AR	0.0295
869	Estrogen receptor beta	ESR2	0.0295
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0288
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0286
6136	Multidrug resistance-associated protein 5	ABCC5	0.0284
26	Vascular endothelial growth factor receptor 3	FLT4	0.0284
122	P2Y purinoceptor 12	P2RY12	0.0283
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.028
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0279
737	Mineralocorticoid receptor	NR3C2	0.0276
32	Vascular endothelial growth factor receptor 1	FLT1	0.0271
6220	Aryl hydrocarbon receptor	AHR	0.0269
407	Vascular endothelial growth factor receptor 2	KDR	0.0267
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0267
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0265
3587	Gastrotropin	FABP6	0.0264
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0263
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.026
36	Insulin receptor	INSR	0.0258
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0258
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0256
4120	NADPH--cytochrome P450 reductase	POR	0.0254
614	Progesterone receptor	PGR	0.0253
124	Histamine H2 receptor	HRH2	0.0251
738	Monocarboxylate transporter 1	SLC16A1	0.0251
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0248
432	D(4) dopamine receptor	DRD4	0.0246
1353	DNA topoisomerase 1	TOP1	0.0242
3552	DNA topoisomerase 1	topA	0.0242
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0242
380	Cytochrome P450 17A1	CYP17A1	0.024
474	Acetylcholinesterase	ACHE	0.0239
477	DNA topoisomerase 4 subunit A	parC	0.0236
886	DNA topoisomerase 4 subunit A	parC	0.0236
6226	DNA topoisomerase 4 subunit A	parC	0.0236
404	DNA gyrase subunit A	gyrA	0.0233
6224	DNA gyrase subunit A	gyrA	0.0233
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0232
904	Glutathione S-transferase P	GSTP1	0.0232
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0232
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0226
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0223
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0223
29	Tubulin beta-1 chain	TUBB1	0.0219
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0218
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0211
373	Transthyretin	TTR	0.0208
232	Corticosteroid-binding globulin	SERPINA6	0.0206
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0202
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0199
818	50S ribosomal protein L10	rplJ	0.0198
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0197
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0197
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0193
3947	Xanthine dehydrogenase/oxidase	XDH	0.0193
4773	Deoxycytidine kinase	DCK	0.0193
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0192
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.019
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0189
6167	Organic solute transporter subunit beta	OSTB	0.0189
6166	Organic solute transporter subunit alpha	OSTA	0.0188
1757	Myeloperoxidase	MPO	0.0188
811	Translocator protein	TSPO	0.0187
244	Angiotensin-converting enzyme	ACE	0.0184
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0183
891	Dihydropteroate synthase	folP	0.0182
5359	Dihydropteroate synthase	folP	0.0182
7175	Dihydropteroate synthase	sulI	0.0182
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.018
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.018
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0179
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0179
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0179
161	Tubulin beta chain	TUBB	0.0178
312	Tubulin beta chain	TUB2	0.0178
2539	Tubulin alpha-1 chain	TUBA4A	0.0178
1656	CYP2B protein	CYP2B	0.0177
716	5-hydroxytryptamine 7 receptor	HTR7	0.0177
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0177
777	Tumor necrosis factor	TNF	0.0176
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0175
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0175
1010	Cytochrome P450 51A1	CYP51A1	0.0174
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0173
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0173
758	Thyroid hormone receptor alpha	THRA	0.0173
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0172
6014	Cytochrome P450 2A13	CYP2A13	0.0172
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0169
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0169
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0169
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0169
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0168
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0168
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0167
163	D(1B) dopamine receptor	DRD5	0.0166
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0166
117	Sterol O-acyltransferase 1	SOAT1	0.0164
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0164
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0163
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0159
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0159
94	5-hydroxytryptamine 4 receptor	HTR4	0.0158
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0156
427	Substance-P receptor	TACR1	0.0154
346	Thyroid hormone receptor beta-1	THRB	0.0154
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0151
952	Dipeptidyl peptidase 4	DPP4	0.015
469	Annexin A1	ANXA1	0.0148
275	Arachidonate 5-lipoxygenase	ALOX5	0.0148
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0148
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0147
594	Thyroxine-binding globulin	SERPINA7	0.0144
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0144
273	Apoptosis regulator Bcl-2	BCL2	0.0142
6020	Aldehyde oxidase	AOX1	0.0142
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0142
131	Synaptic vesicular amine transporter	SLC18A2	0.0141
1517	Beta-3 adrenergic receptor	ADRB3	0.0138
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0138
4237	50S ribosomal protein L22	rplV	0.0138
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0137
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0137
165	FL cytokine receptor	FLT3	0.0135
6085	Fatty acid-binding protein, intestinal	FABP2	0.0134
174	Sigma 1-type opioid receptor	SIGMAR1	0.0134
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0132
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0132
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0132
4238	50S ribosomal protein L4	rplD	0.0129
5578	50S ribosomal protein L4	rplD	0.0129
6173	50S ribosomal protein L4	rplD	0.0129
6219	50S ribosomal protein L4	rplD	0.0129
768	FK506-binding protein 1A	FKBP1A	0.0128
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0128
3810	Catechol O-methyltransferase	COMT	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0126
4122	Histone deacetylase 2	HDAC2	0.0125
705	Glutamate receptor 1	GRIA1	0.0125
1178	Adenosine A2a receptor	ADORA2A	0.0124
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0124
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0123
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0123
1618	High affinity nerve growth factor receptor	NTRK1	0.0123
1192	Sulfotransferase 1A1	SULT1A1	0.0122
571	Melatonin receptor type 1A	MTNR1A	0.0122
362	Melatonin receptor type 1B	MTNR1B	0.0122
992	Protein tyrosine kinase 2 beta	PTK2B	0.0121
16	Adenosine A1 receptor	ADORA1	0.012
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0119
1630	Integrin beta-2	ITGB2	0.0118
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0118
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0116
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0116
365	Dihydrofolate reductase	DHFR	0.0115
2381	Dihydrofolate reductase	DFR1	0.0115
2833	Dihydrofolate reductase	Not Available	0.0115
2931	Dihydrofolate reductase	folA	0.0115
3544	Dihydrofolate reductase	folA	0.0115
3682	Dihydrofolate reductase	folA	0.0115
6642	Dihydrofolate reductase	folA	0.0115
6756	Dihydrofolate reductase	dfrA	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0114
6044	Serum paraoxonase/lactonase 3	PON3	0.0113
482	Glycine receptor subunit alpha-1	GLRA1	0.0113
6102	Arylamine N-acetyltransferase 2	NAT2	0.0112
1852	Microtubule-associated protein 2	MAP2	0.0112
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.011
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.011
976	Platelet glycoprotein IX	GP9	0.0108
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0108
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0107
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0107
295	Carbonic anhydrase 1	CA1	0.0107
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0106
5880	Thrombopoietin receptor	MPL	0.0106
3856	Fibroblast growth factor receptor 3	FGFR3	0.0106
563	Thyroid peroxidase	TPO	0.0106
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0106
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0105
6146	High affinity copper uptake protein 1	SLC31A1	0.0105
823	Fibroblast growth factor receptor 2	FGFR2	0.0105
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0104
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0102
284	DNA-directed RNA polymerase beta chain	rpoB	0.0102
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0102
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0101
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0101
908	Glutathione S-transferase theta-1	GSTT1	0.0101
6432	Transporter	snf	0.0101
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0101
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.01
6149	Solute carrier family 22 member 10	SLC22A10	0.01
239	Coagulation factor X	F10	0.0099
84	Nuclear receptor 0B1	NR0B1	0.0099
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0099
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0099
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0099
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0098
4203	Histamine N-methyltransferase	HNMT	0.0098
3809	Estrogen-related receptor gamma	ESRRG	0.0098
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0097
509	Thymidine kinase	TK	0.0097
570	Thymidine kinase	TK	0.0097
2559	Thymidine kinase	TK	0.0097
3430	Thymidine kinase	tdk	0.0097
3518	Thymidine kinase	TK	0.0097
5301	Thymidine kinase	tdk	0.0097
5771	Thymidine kinase	ORF36	0.0097
7009	Thymidine kinase	ORF36	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
592	Carbonic anhydrase 4	CA4	0.0097
183	Vascular endothelial growth factor A	VEGFA	0.0097
5787	Angiopoietin-1 receptor	TEK	0.0096
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
49	Endothelin B receptor	EDNRB	0.0096
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0095
603	DNA polymerase alpha catalytic subunit	POLA1	0.0094
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0094
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0094
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0094
68	Cannabinoid receptor 1	CNR1	0.0094
5923	Microtubule-associated protein tau	MAPT	0.0094
5924	Microtubule-associated protein 4	MAP4	0.0094
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0093
921	Glutamate receptor 2	GRIA2	0.0093
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0092
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0092
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0092
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0092
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0092
319	Opioid receptor, sigma 1	OPRS1	0.009
578	Endothelin-1 receptor	EDNRA	0.009
24	Thymidylate synthase	TMP1	0.009
359	Thymidylate synthase	TYMS	0.009
2626	Thymidylate synthase	thyA	0.009
2729	Thymidylate synthase	thyA	0.009
5352	Thymidylate synthase	THYA	0.009
672	Prostaglandin F2-alpha receptor	PTGFR	0.009
5251	Carbonyl reductase [NADPH] 1	CBR1	0.009
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0088
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0088
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
1650	Heme carrier protein 1	SLC46A1	0.0087
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0085
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0084
199	Monocarboxylate transporter 8	SLC16A2	0.0083
751	Potassium channel subfamily K member 6	KCNK6	0.0082
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0081
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0081
153	Dopamine beta-hydroxylase	DBH	0.0081
814	Ryanodine receptor 1	RYR1	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
2112	Toll-like receptor 9	TLR9	0.008
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.008
1525	Heparin-binding growth factor 2	FGF2	0.008
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0079
572	Integrin alpha-L	ITGAL	0.0079
173	Toll-like receptor 7	TLR7	0.0079
6163	Copper-transporting ATPase 2	ATP7B	0.0078
6165	Copper-transporting ATPase 1	ATP7A	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0077
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0077
2449	Tubulin alpha-3 chain	TUBA1A	0.0076
7	Nitric oxide synthase, inducible	NOS2	0.0075
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0075
1864	RET proto-oncogene	RET	0.0075
172	Potassium channel subfamily K member 1	KCNK1	0.0075
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0075
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0075
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0075
54	Prothrombin	F2	0.0074
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0074
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0074
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0073
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
780	Retinoic acid receptor RXR-gamma	RXRG	0.0073
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0073
6171	Solute carrier family 28 member 3	SLC28A3	0.0073
6010	Thiamine transporter 1	SLC19A2	0.0073
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0072
4116	Dihydropteroate synthetase	Not Available	0.0072
5300	Antigen peptide transporter 1	TAP1	0.0072
357	Carbonic anhydrase 2	CA2	0.0072
896	Glutathione S-transferase Mu 1	GSTM1	0.0072
6138	Multidrug resistance protein 3	ABCB4	0.0072
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0072
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0072
936	Ephrin type-A receptor 2	EPHA2	0.0072
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0072
6164	POU domain, class 5, transcription factor 1	POU5F1	0.007
1050	Bile salt sulfotransferase	SULT2A1	0.0069
1760	Aminopeptidase N	ANPEP	0.0069
6843	Aminopeptidase N	pepN	0.0069
3932	Glutathione S-transferase A2	GSTA2	0.0069
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0069
106	Cannabinoid receptor 2	CNR2	0.0068
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
1629	Transcription factor AP-1	JUN	0.0067
4192	DNA topoisomerase 2-beta	TOP2B	0.0067
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0067
88	Retinoic acid receptor RXR-beta	RXRB	0.0066
5934	Cytochrome P450 26A1	CYP26A1	0.0066
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0066
175	Thiamin pyrophosphokinase 1	TPK1	0.0066
2499	Tubulin beta-2C chain	TUBB2C	0.0065
1196	Complement decay-accelerating factor	CD55	0.0065
6043	Putative G-protein coupled receptor 44	GPR44	0.0065
6070	Nischarin	NISCH	0.0065
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0064
164	Histamine H4 receptor	HRH4	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
856	Vitamin D3 receptor	VDR	0.0063
4311	tRNA	TRDMT1	0.0063
4325	tRNA	trmD	0.0063
4328	tRNA	trmD	0.0063
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0063
133	Dihydropterate synthase	sulI	0.0063
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0063
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
6151	Monocarboxylate transporter 10	SLC16A10	0.0062
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0061
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0061
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0061
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0061
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
6126	Carbonic anhydrase 7	CA7	0.006
3611	Cytidine deaminase	cdd	0.0059
3707	Cytidine deaminase	cdd	0.0059
4211	Cytidine deaminase	CDA	0.0059
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0059
267	Plasminogen activator inhibitor 1	SERPINE1	0.0059
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0059
1830	5'-nucleotidase	NT5E	0.0059
293	Gamma-glutamyl hydrolase	GGH	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0058
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0058
1483	Membrane copper amine oxidase	AOC3	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
4103	Proteasome subunit beta type 2	PSMB2	0.0057
4102	Proteasome subunit beta type 5	PSMB5	0.0056
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0056
4101	Proteasome subunit beta type 1	PSMB1	0.0056
2808	Chloramphenicol acetyltransferase 3	cat3	0.0056
6174	50S ribosomal protein L32	rpmF	0.0056
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0056
518	Peroxidase/catalase T	katG	0.0055
6506	Stathmin-4	STMN4	0.0055
581	Cytochrome P450 2R1	CYP2R1	0.0054
558	Solute carrier family 12 member 1	SLC12A1	0.0054
6221	Steroid hormone receptor ERR1	ESRRA	0.0053
1275	Estrogen sulfotransferase	SULT1E1	0.0053
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
828	Phenylalanine-4-hydroxylase	PAH	0.0052
3109	Phenylalanine-4-hydroxylase	phhA	0.0052
712	Tubulin alpha chain	TUB1	0.0052
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0052
6168	Solute carrier family 22 member 16	SLC22A16	0.0052
2300	Lysozyme	E	0.0052
3633	Lysozyme	R	0.0052
5597	Lysozyme	17	0.0052
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0052
3601	Dihydropteroate synthase 1	folP1	0.0052
3807	Dihydropteroate synthase 1	folP1	0.0052
3808	Dihydropteroate synthase 2	folP2	0.0052
2417	Chloramphenicol acetyltransferase	cat	0.0052
3278	Chloramphenicol acetyltransferase	cat	0.0052
694	Matrix protein 2	M	0.0051
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
6824	Tyrosine-protein kinase Lyn	LYN	0.0051
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0051
461	Glycine receptor subunit alpha-3	GLRA3	0.0051
2810	Dr hemagglutinin structural subunit	draA	0.0051
1341	Histamine H3 receptor	HRH3	0.0051
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.005
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
5626	Nucleoside diphosphate kinase B	NME2	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.005
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.005
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.005
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.005
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.005
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0049
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0049
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0049
6111	DNA polymerase epsilon subunit 4	POLE4	0.0049
6112	DNA polymerase epsilon subunit 3	POLE3	0.0048
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0048
6110	DNA polymerase epsilon subunit 2	POLE2	0.0048
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0048
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0047
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0047
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0047
702	UMP-CMP kinase	CMPK1	0.0047
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0047
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0047
1291	cAMP response element-binding protein	CREB1	0.0047
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0047
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
760	Fibroblast growth factor 1	FGF1	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
6218	Pannexin-1	PANX1	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
4210	Toll-like receptor 4	TLR4	0.0046
3086	Plasmepsin-2	Not Available	0.0046
634	Squalene monooxygenase	SQLE	0.0046
7196	Squalene monooxygenase	ERG1	0.0046
527	Prostacyclin receptor	PTGIR	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0045
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0045
6033	High affinity interleukin-8 receptor A	CXCR1	0.0045
489	Monocarboxylate transporter 2	SLC16A7	0.0045
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0044
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0044
517	Alcohol dehydrogenase 1C	ADH1C	0.0044
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0044
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0044
5798	Mitogen-activated protein kinase 11	MAPK11	0.0044
2216	Fibroblast growth factor receptor 4	FGFR4	0.0043
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0043
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0043
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0043
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0042
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0042
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
3957	Adenosine deaminase	ADA	0.0042
4217	Telomerase reverse transcriptase	TERT	0.0042
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0042
1992	Vitamin D-binding protein	GC	0.0042
5818	Folate receptor alpha	FOLR1	0.0041
1648	Elastin	ELN	0.0041
162	Retinoic acid receptor gamma-1	RARG	0.0041
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0041
5294	Nucleoside diphosphate kinase A	NME1	0.0041
6048	Troponin C, skeletal muscle	TNNC2	0.0041
125	DNA polymerase beta	POLB	0.0041
3913	Glutamic acid decarboxylase	GAD65	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
719	Retinoic acid receptor responder protein 1	RARRES1	0.0041
770	Retinoic acid-induced protein 3	GPRC5A	0.0041
123	Diamine acetyltransferase 1	SAT1	0.004
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.004
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.004
484	Tyrosine-protein kinase ABL2	ABL2	0.004
1262	Corticotropin-lipotropin	POMC	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1541	Metalloproteinase	mmp20	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
2472	Voltage-gated potassium channel	kcsA	0.0038
6366	Voltage-gated potassium channel	kcsA	0.0038
85	Growth hormone receptor	GHR	0.0038
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0037
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0036
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0036
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0036
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0036
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0036
2599	Tyrosine-protein kinase HCK	HCK	0.0036
2021	Thrombomodulin	THBD	0.0036
3639	Thymidine phosphorylase	deoA	0.0036
3936	Thymidine phosphorylase	TYMP	0.0036
291	Nitric-oxide synthase, endothelial	NOS3	0.0036
251	Alcohol dehydrogenase 1A	ADH1A	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
569	Retinal dehydrogenase 2	ALDH1A2	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
444	Alcohol dehydrogenase 1B	ADH1B	0.0035
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0035
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0035
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0035
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0035
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
3904	Alanine aminotransferase 2	GPT2	0.0034
735	Alanine aminotransferase 1	GPT	0.0034
820	Glycine receptor subunit alpha-2	GLRA2	0.0034
611	Retinal dehydrogenase 1	ALDH1A1	0.0033
2320	Thymidine kinase, cytosolic	TK1	0.0033
1039	Histone deacetylase 9	HDAC9	0.0033
65	Matrix metalloproteinase-9	Not Available	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
3937	Fatty-acid amide hydrolase	FAAH	0.0032
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0032
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
1374	Natriuretic peptides B	NPPB	0.0031
1827	Gap junction alpha-1 protein	GJA1	0.0031
1908	Vascular cell adhesion protein 1	VCAM1	0.0031
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
2391	Ferrochelatase	hemH	0.0031
6502	Ferrochelatase	DKFZp686P18130	0.0031
1591	Ferrochelatase, mitochondrial	FECH	0.0031
4226	Uridine phosphorylase 2	UPP2	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
6228	Nuclear receptor coactivator 1	NCOA1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.003
6241	Nuclear receptor coactivator 2	NCOA2	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
5126	Arginase	rocF	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0029
277	Purine nucleoside phosphorylase	PNP	0.0029
2870	Purine nucleoside phosphorylase	punA	0.0029
2945	Purine nucleoside phosphorylase	punA	0.0029
4659	Purine nucleoside phosphorylase	TM_1596	0.0029
4825	Purine nucleoside phosphorylase	TTHA1435	0.0029
4225	Uridine phosphorylase 1	UPP1	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
663	Solute carrier family 12 member 4	SLC12A4	0.0029
53	Solute carrier family 12 member 5	SLC12A5	0.0029
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0028
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0027
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0027
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0027
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0027
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0027
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0027
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0027
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0027
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0027
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0027
6559	Cytochrome c oxidase subunit 2	ctaC	0.0027
6669	Cytochrome c oxidase subunit 2	ctaC	0.0027
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0027
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0027
6558	Cytochrome c oxidase subunit 1	ctaD	0.0027
6042	Prostaglandin reductase 2	PTGR2	0.0027
310	Solute carrier family 12 member 2	SLC12A2	0.0027
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0026
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0026
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0026
413	Amidophosphoribosyltransferase	PPAT	0.0026
2515	Amidophosphoribosyltransferase	purF	0.0026
3714	Amidophosphoribosyltransferase	purF	0.0026
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
6859	Protein S100-A4	S100A4	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
6837	Serine/threonine-protein kinase 17B	STK17B	0.0025
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0025
3830	Calreticulin	CALR	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
1792	Tissue-type plasminogen activator	PLAT	0.0025
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0025
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0025
2540	Choloylglycine hydrolase	cbh	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6034	Hydroxyindole O-methyltransferase	ASMT	0.0023
6035	Nuclear receptor ROR-beta	RORB	0.0023
6036	Eosinophil peroxidase	EPX	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0023
5816	Cadherin-5	CDH5	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
1714	Mitogen-activated protein kinase 3	MAPK3	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
3404	Exotoxin A	eta	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
268	Adenosine A2b receptor	ADORA2B	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
1313	Lactoylglutathione lyase	GLO1	0.002
765	Indoleamine 2,3-dioxygenase	IDO1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
76	Nitric-oxide synthase, brain	NOS1	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
1058	Cell division protein kinase 5	CDK5	0.002
2207	Rhodopsin	RHO	0.002
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
6500	Phospholipase A2	PLA2G1B	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0018
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0018
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
229	Retinoic acid receptor beta	RARB	0.0017
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0017
730	Retinoic acid receptor alpha	RARA	0.0017
5682	Ribonuclease pancreatic	RNASE1	0.0017
1074	Urokinase-type plasminogen activator	PLAU	0.0017
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0016
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0016
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0016
1686	Choline transporter-like protein 1	SLC44A1	0.0016
3926	Choline transporter-like protein 2	SLC44A2	0.0016
861	Choline kinase alpha	CHKA	0.0016
3927	Choline transporter-like protein 3	SLC44A3	0.0016
769	High-affinity choline transporter 1	SLC5A7	0.0016
700	Choline dehydrogenase, mitochondrial	CHDH	0.0016
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0016
3925	Choline transporter-like protein 4	SLC44A4	0.0016
576	Choline O-acetyltransferase	CHAT	0.0016
3922	Phospholipase D2	PLD2	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
3924	Phospholipase D1	PLD1	0.0016
1243	Cathepsin D	CTSD	0.0016
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0016
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3221	Cytochrome c4	cc4	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6459	Glycodelin	PAEP	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
4386	Hemoglobin-like protein HbN	glbN	0.0009
2298	Cytochrome P450-cam	camC	0.0009
2132	Protein S100-B	S100B	0.0009
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
822	Aldose reductase	AKR1B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1507	Cytochrome c	CYCS	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
4954	Soluble cytochrome b558	Not Available	0.0006
4925	Cytochrome c-type protein SHP	shp	0.0006
4916	Cyanoglobin	glbN	0.0006
4915	Cytochrome c-550	psbV	0.0006
4959	Cytochrome c-550	psbV	0.0006
5216	Cytochrome c-550	psbV	0.0006
4947	Bacterial hemoglobin	vhb	0.0006
4934	Cytochrome c-551	nirM	0.0006
5218	Cytochrome c-551	nirM	0.0006
4994	Hemoglobin-like protein HbO	glbO	0.0006
4984	Neuroglobin	NGB	0.0006
4943	Cytochrome c6	petJ	0.0006
4975	Cytochrome c-556	RPA3973	0.0006
4905	Cytochrome c2	Not Available	0.0006
4939	Cytochrome c2	cycA	0.0006
4964	Cytochrome c2	cycA	0.0006
4979	Cytochrome c2	cycA	0.0006
6673	Cytochrome c2	cycA	0.0006
4910	Cytoglobin	CYGB	0.0006
4936	Cytochrome c2 iso-2	Not Available	0.0006
4998	Hemoglobin-like protein yjbI	yjbI	0.0006
4981	Iron-starvation protein PigA	pigA	0.0006
5000	HemO	hemO	0.0006
4907	Cytochrome c-L	moxG	0.0006
6865	Cytochrome c-L	moxG	0.0006
4909	CooA protein	cooA	0.0006
4935	Cytochrome c-554	cycA1	0.0006
4942	Diheme cytochrome c napB	napB	0.0006
644	Heme oxygenase 2	HMOX2	0.0006
4982	Heme oxygenase 2	pbsA2	0.0006
4971	Nonaheme cytochrome c	hmcA	0.0006
4904	Cytochrome c family protein	GSU1996	0.0006
4961	Hemophore HasA	hasA	0.0006
4976	Apocytochrome f	petA	0.0006
6407	Apocytochrome f	petA	0.0006
4764	Cytochrome P450 165C4	CYP165C4	0.0006
4972	P450cin	cinA	0.0006
4931	Cytochrome P450 167A1	CYP167A1	0.0006
4960	Putative cytochrome P450-family protein	SCO7417	0.0006
4903	Methyl-accepting chemotaxis protein	Tar4	0.0006
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0006
4999	Cytochrome P450 165B3	CYP165B3	0.0006
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0006
4989	Cytochrome c551 peroxidase	ccp	0.0006
5222	Cytochrome c551 peroxidase	ccpA	0.0006
4937	Cytochrome oxidase subunit II	rcoxA	0.0006
4922	Cytochrome c, putative	SO_4144	0.0006
4993	Hydroxylamine oxidoreductase	hao1	0.0006
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0006
3093	Catalase HPII	katE	0.0006
4952	Catalase/peroxidase	katA	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
798	Osteocalcin	BGLAP	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
369	Coagulation factor VII	F7	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
2230	Catalase	CAT	0.0004
3249	Catalase	katA	0.0004
3625	Catalase	katA	0.0004
4539	Catalase	katA	0.0004
4941	Catalase	katB	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
3411	Cytochrome P450 121	cyp121	0.0004
3670	Soluble cytochrome b562 precursor	cybC	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
3291	Cytochrome c-552	cycA	0.0004
4927	Cytochrome c-552	nrfA	0.0004
4938	Cytochrome c-552	cycA	0.0004
4953	Cytochrome c-552	nrfA	0.0004
5217	Cytochrome c-552	cycM	0.0004
2617	Nitric oxide synthase oxygenase	nos	0.0004
2701	Nitric oxide synthase oxygenase	nos	0.0004
3102	Flavohemoprotein	hmp	0.0004
4969	Flavohemoprotein	hmp	0.0004
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
358	Cystathionine beta-synthase	CBS	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
693	Hemoglobin subunit beta	HBB	0.0003
6268	Hydroxyacid oxidase 1	HAO1	0.0003
810	Heme oxygenase 1	HMOX1	0.0003
3391	Heme oxygenase 1	pbsA1	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00220 - Nelfinavir

Targets

Enzymes

Transporters

Predictions