DT-Web: DB08881

Identification

Name

Vemurafenib

Accession Number

DB08881

Type

small molecule

Description

Vemurafenib is a BRAF enzyme inhibitor developed by Plexxikon and Genentech for the treatment of late-stage melanoma. [Wikipedia] The cobas(R) 4800 BRAF B600 mutation test provided by Roche Molecular Systems is the diagnostic test to confirm eligibility for treatment. FDA approved on August 17, 2011 under the company Hoffmann La Roche.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antineoplastic Agents

Molecular Weight

489.922

Groups

approved

Monoisotopic Weight

489.072546264

Pharmacology

Indication

Treatment of unresectable or metastatic melanoma in patients with the BRAF-V600 mutation.

Mechanism of action

Vemurafenib is an orally available inhibitor of mutated BRAF-serine-threonine kinase. It is especially potent against the BRAF V600E mutation. This mutation involves the substitution of glutamic acid for valine at codon 600. The BRAF oncogene, most of which have the V600E mutation, activates mitogen-activated kinase (MAPK) pathway which results in cell growth, proliferation, and metastasis. Vemurafenib blocks these downstream processes to inhibit tumour growth and eventually trigger apoptosis. Vemurafenib does not have antitumour effects against melanoma cell lines with the wild-type BRAF mutation.

Absorption

After oral administration of vemurafenib, it is well absorbed. Bioavailability is unknown. Peak concentrations are reached in 3 hours when an oral dose of 960 mg twice daily for 15 days has been given to patients. Exposure is highly variable between different patients. Gastrointestinal fluid content, pH, volumes, motility, transition time and bile composition may be factors affecting exposure. It is unknown how food affects the absorption of vemurafenib. Time to steady state = 15 - 22 days

Protein binding

>99% protein bound to serum albumin and alpha-1 acid glycoprotein.

Biotransformation

Vemurafenib is metabolized by CYP3A4 and the metabolites make up 5% of the components in plasma. The parent compound makes up for the remaining 95%.

Route of elimination

Excreted via feces (94%) and urine (1%).

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Caffeine	Vemurafenib increases the AUC of caffeine (CYP1A2 substrate) 2.6-fold.
Carbamazepine	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Clarithromycin	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Dextromethorphan	Vemurafenib increases the AUC (CYP2D6 substrate) by 47% .
Indinavir	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Itraconazole	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Ketoconazole	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Midazolam	Vemurafenib decreases the AUC (CYP3A4 substrate) by 39%.
Nefazodone	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Nelfinavir	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Phenobarbital	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Phenytoin	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Rifabutin	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Rifampin	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Rifapentine	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Ritonavir	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Saquinavir	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Telithromycin	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Voriconazole	Strong CYP3A4 inhibitors may increase levels of vemurafenib. Monitor concomitant therapy closely.
Warfarin	Vemurafenib increases the AUC of S-warfarin (CYP2C9 substrate). Monitor concomitant therapy closely.

Food Interactions

Not Available

B-Raf proto-oncogene serine/threonine-protein kinase
Name	B-Raf proto-oncogene serine/threonine-protein kinase
Gene Name	BRAF
Pharmacological action	yes
Actions	inhibitor
References	Jordan EJ, Kelly CM: Vemurafenib for the treatment of melanoma. Expert Opin Pharmacother. 2012 Dec;13(17):2533-43. doi: 10.1517/14656566.2012.737780. Epub 2012 Oct 24. - Pubmed
DTHybrid score	0.9071

Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	inhibitor
References	Jordan EJ, Kelly CM: Vemurafenib for the treatment of melanoma. Expert Opin Pharmacother. 2012 Dec;13(17):2533-43. doi: 10.1517/14656566.2012.737780. Epub 2012 Oct 24. - Pubmed
DTHybrid score	0.3798
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Jordan EJ, Kelly CM: Vemurafenib for the treatment of melanoma. Expert Opin Pharmacother. 2012 Dec;13(17):2533-43. doi: 10.1517/14656566.2012.737780. Epub 2012 Oct 24. - Pubmed
DTHybrid score	0.4258
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Jordan EJ, Kelly CM: Vemurafenib for the treatment of melanoma. Expert Opin Pharmacother. 2012 Dec;13(17):2533-43. doi: 10.1517/14656566.2012.737780. Epub 2012 Oct 24. - Pubmed
DTHybrid score	0.5671

Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	substrate,inhibitor
References	Mittapalli RK, Vaidhyanathan S, Sane R, Elmquist WF: Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032). J Pharmacol Exp Ther. 2012 Jul;342(1):33-40. doi: 10.1124/jpet.112.192195. Epub 2012 Mar 27. - Pubmed
DTHybrid score	0.2216
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	substrate
References	Mittapalli RK, Vaidhyanathan S, Sane R, Elmquist WF: Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on the brain distribution of a novel BRAF inhibitor: vemurafenib (PLX4032). J Pharmacol Exp Ther. 2012 Jul;342(1):33-40. doi: 10.1124/jpet.112.192195. Epub 2012 Mar 27. - Pubmed
DTHybrid score	0.2829

Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.2216
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.2829

Id	Partner name	Gene Name	Score
1588	Multidrug resistance protein 1	ABCB1	0.2986
4757	Cytochrome P450 2C9	CYP2C9	0.2481
6016	Cytochrome P450 2C19	CYP2C19	0.2144
4924	Cytochrome P450 2C8	CYP2C8	0.1876
4118	Cytochrome P450 3A5	CYP3A5	0.1818
6030	Cytochrome P450 2B6	CYP2B6	0.1302
6107	Cytochrome P450 3A7	CYP3A7	0.1254
6024	Cytochrome P450 1A1	CYP1A1	0.1091
6013	Cytochrome P450 2E1	CYP2E1	0.1074
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0956
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0834
1729	Solute carrier family 22 member 6	SLC22A6	0.0782
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0657
20	Prostaglandin G/H synthase 1	PTGS1	0.0629
5718	Cytochrome P450 2A6	CYP2A6	0.0619
556	Alpha-1A adrenergic receptor	ADRA1A	0.0598
492	Histamine H1 receptor	HRH1	0.0597
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0595
6145	Solute carrier family 22 member 1	SLC22A1	0.0581
824	Sodium-dependent serotonin transporter	SLC6A4	0.0568
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0563
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0551
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.054
6142	Solute carrier family 22 member 8	SLC22A8	0.0519
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0511
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0505
1898	Cytochrome P450 1B1	CYP1B1	0.0484
817	DNA topoisomerase 2-alpha	TOP2A	0.0483
2164	Multidrug resistance-associated protein 4	ABCC4	0.0471
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0468
6144	Solute carrier family 22 member 2	SLC22A2	0.0466
831	D(2) dopamine receptor	DRD2	0.046
776	Bile salt export pump	ABCB11	0.0459
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0454
290	Prostaglandin G/H synthase 2	PTGS2	0.0435
118	Organic cation/carnitine transporter 2	SLC22A5	0.0409
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0401
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0395
318	Alpha-2A adrenergic receptor	ADRA2A	0.0378
632	Alpha-1B adrenergic receptor	ADRA1B	0.0374
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.037
766	Beta-2 adrenergic receptor	ADRB2	0.0368
844	Epidermal growth factor receptor	EGFR	0.0367
193	Beta-1 adrenergic receptor	ADRB1	0.0366
731	HIV-1 protease	HIV-1 protease	0.0359
6106	Cytochrome P450 2C18	CYP2C18	0.0357
23	D(1A) dopamine receptor	DRD1	0.0341
504	Mast/stem cell growth factor receptor	KIT	0.0336
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0328
36	Insulin receptor	INSR	0.0325
713	Sodium-dependent dopamine transporter	SLC6A3	0.0324
6143	Solute carrier family 22 member 7	SLC22A7	0.0321
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0316
789	Alpha-1D adrenergic receptor	ADRA1D	0.0316
6137	Multidrug resistance-associated protein 6	ABCC6	0.0313
3811	Cytochrome P450 19A1	CYP19A1	0.0307
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0297
6147	Solute carrier family 22 member 3	SLC22A3	0.0296
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0292
6148	Multidrug resistance-associated protein 7	ABCC10	0.0285
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0284
847	Mu-type opioid receptor	OPRM1	0.0284
1024	Solute carrier family 22 member 11	SLC22A11	0.0283
26	Vascular endothelial growth factor receptor 3	FLT4	0.0282
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0282
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0276
32	Vascular endothelial growth factor receptor 1	FLT1	0.0274
136	Estrogen receptor	ESR1	0.0274
5787	Angiopoietin-1 receptor	TEK	0.0272
3941	Amine oxidase [flavin-containing] A	MAOA	0.0265
871	Glucocorticoid receptor	NR3C1	0.0261
407	Vascular endothelial growth factor receptor 2	KDR	0.0252
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.025
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0246
891	Dihydropteroate synthase	folP	0.0245
5359	Dihydropteroate synthase	folP	0.0245
7175	Dihydropteroate synthase	sulI	0.0245
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0243
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0239
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0239
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0239
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0226
465	Calmodulin	CALM1	0.0222
833	Organic cation/carnitine transporter 1	SLC22A4	0.0218
3923	Cholinesterase	BCHE	0.0217
696	Kappa-type opioid receptor	OPRK1	0.0216
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0214
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0213
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0203
477	DNA topoisomerase 4 subunit A	parC	0.0203
886	DNA topoisomerase 4 subunit A	parC	0.0203
6226	DNA topoisomerase 4 subunit A	parC	0.0203
6141	Sodium/bile acid cotransporter	SLC10A1	0.0203
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0202
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0201
404	DNA gyrase subunit A	gyrA	0.02
6224	DNA gyrase subunit A	gyrA	0.02
467	Delta-type opioid receptor	OPRD1	0.0199
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0194
629	Alpha-2B adrenergic receptor	ADRA2B	0.0193
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.019
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0189
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0187
380	Cytochrome P450 17A1	CYP17A1	0.0186
638	D(3) dopamine receptor	DRD3	0.0183
3939	Amine oxidase [flavin-containing] B	MAOB	0.0179
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0179
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0178
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0178
1618	High affinity nerve growth factor receptor	NTRK1	0.0177
1353	DNA topoisomerase 1	TOP1	0.0176
3552	DNA topoisomerase 1	topA	0.0176
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0175
183	Vascular endothelial growth factor A	VEGFA	0.0174
378	Alpha-2C adrenergic receptor	ADRA2C	0.0172
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0172
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0172
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0172
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
738	Monocarboxylate transporter 1	SLC16A1	0.0169
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0164
5798	Mitogen-activated protein kinase 11	MAPK11	0.016
29	Tubulin beta-1 chain	TUBB1	0.0152
468	Cytochrome P450 4A11	CYP4A11	0.0152
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0151
1050	Bile salt sulfotransferase	SULT2A1	0.0151
165	FL cytokine receptor	FLT3	0.015
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.015
373	Transthyretin	TTR	0.0148
161	Tubulin beta chain	TUBB	0.0148
312	Tubulin beta chain	TUB2	0.0148
33	Cystine/glutamate transporter	SLC7A11	0.0148
4604	Liver carboxylesterase 1	CES1	0.0147
432	D(4) dopamine receptor	DRD4	0.0144
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
1517	Beta-3 adrenergic receptor	ADRB3	0.014
6220	Aryl hydrocarbon receptor	AHR	0.0137
936	Ephrin type-A receptor 2	EPHA2	0.0136
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0135
3947	Xanthine dehydrogenase/oxidase	XDH	0.0134
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0134
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0134
6136	Multidrug resistance-associated protein 5	ABCC5	0.0133
614	Progesterone receptor	PGR	0.0133
823	Fibroblast growth factor receptor 2	FGFR2	0.0133
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0132
756	Sex hormone-binding globulin	SHBG	0.0132
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0131
436	5-hydroxytryptamine 2B receptor	HTR2B	0.013
3307	Acriflavine resistance protein B	acrB	0.013
992	Protein tyrosine kinase 2 beta	PTK2B	0.0129
869	Estrogen receptor beta	ESR2	0.0129
1757	Myeloperoxidase	MPO	0.0129
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0127
117	Sterol O-acyltransferase 1	SOAT1	0.0125
273	Apoptosis regulator Bcl-2	BCL2	0.0125
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0124
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0124
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0123
4120	NADPH--cytochrome P450 reductase	POR	0.0122
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0122
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0122
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0119
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
6031	Cytochrome P450 3A43	CYP3A43	0.0116
70	Type-1 angiotensin II receptor	AGTR1	0.0113
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0109
163	D(1B) dopamine receptor	DRD5	0.0109
952	Dipeptidyl peptidase 4	DPP4	0.0108
4773	Deoxycytidine kinase	DCK	0.0108
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0106
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0106
6085	Fatty acid-binding protein, intestinal	FABP2	0.0106
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0105
1656	CYP2B protein	CYP2B	0.0105
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0102
474	Acetylcholinesterase	ACHE	0.0102
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0101
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0101
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.01
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.01
260	Cytochrome P450 51	ERG11	0.01
761	Cytochrome P450 51	ERG11	0.01
3163	Cytochrome P450 51	cyp51	0.01
6182	Cytochrome P450 2J2	CYP2J2	0.01
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.01
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.01
904	Glutathione S-transferase P	GSTP1	0.0099
2211	Fatty acid-binding protein, heart	FABP3	0.0098
705	Glutamate receptor 1	GRIA1	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0095
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
566	Serotransferrin	TF	0.0094
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0092
716	5-hydroxytryptamine 7 receptor	HTR7	0.0092
2539	Tubulin alpha-1 chain	TUBA4A	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
482	Glycine receptor subunit alpha-1	GLRA1	0.0091
146	Androgen receptor	AR	0.0091
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0091
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0091
818	50S ribosomal protein L10	rplJ	0.0089
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0088
768	FK506-binding protein 1A	FKBP1A	0.0088
122	P2Y purinoceptor 12	P2RY12	0.0087
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0087
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0087
16	Adenosine A1 receptor	ADORA1	0.0087
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0087
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0086
908	Glutathione S-transferase theta-1	GSTT1	0.0085
461	Glycine receptor subunit alpha-3	GLRA3	0.0085
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0084
1852	Microtubule-associated protein 2	MAP2	0.0084
1178	Adenosine A2a receptor	ADORA2A	0.0082
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0082
6014	Cytochrome P450 2A13	CYP2A13	0.0081
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0081
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
4237	50S ribosomal protein L22	rplV	0.008
5923	Microtubule-associated protein tau	MAPT	0.008
5924	Microtubule-associated protein 4	MAP4	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
6043	Putative G-protein coupled receptor 44	GPR44	0.0079
4192	DNA topoisomerase 2-beta	TOP2B	0.0079
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0079
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0079
173	Toll-like receptor 7	TLR7	0.0079
124	Histamine H2 receptor	HRH2	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0077
6432	Transporter	snf	0.0077
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0076
777	Tumor necrosis factor	TNF	0.0076
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0073
6020	Aldehyde oxidase	AOX1	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0071
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0071
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.007
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.007
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0068
6149	Solute carrier family 22 member 10	SLC22A10	0.0067
1650	Heme carrier protein 1	SLC46A1	0.0067
1629	Transcription factor AP-1	JUN	0.0067
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0067
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0067
94	5-hydroxytryptamine 4 receptor	HTR4	0.0067
811	Translocator protein	TSPO	0.0067
4238	50S ribosomal protein L4	rplD	0.0067
5578	50S ribosomal protein L4	rplD	0.0067
6173	50S ribosomal protein L4	rplD	0.0067
6219	50S ribosomal protein L4	rplD	0.0067
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0066
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0066
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0066
6102	Arylamine N-acetyltransferase 2	NAT2	0.0066
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0066
275	Arachidonate 5-lipoxygenase	ALOX5	0.0065
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0065
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0064
2449	Tubulin alpha-3 chain	TUBA1A	0.0064
571	Melatonin receptor type 1A	MTNR1A	0.0064
362	Melatonin receptor type 1B	MTNR1B	0.0064
3932	Glutathione S-transferase A2	GSTA2	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0062
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0062
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0062
68	Cannabinoid receptor 1	CNR1	0.0062
6146	High affinity copper uptake protein 1	SLC31A1	0.0062
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0061
284	DNA-directed RNA polymerase beta chain	rpoB	0.006
5773	DNA-directed RNA polymerase beta chain	rpoB	0.006
3856	Fibroblast growth factor receptor 3	FGFR3	0.006
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
6167	Organic solute transporter subunit beta	OSTB	0.0059
6166	Organic solute transporter subunit alpha	OSTA	0.0059
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0059
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0059
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0059
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0059
1864	RET proto-oncogene	RET	0.0058
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0058
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0058
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0058
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0058
365	Dihydrofolate reductase	DHFR	0.0058
2381	Dihydrofolate reductase	DFR1	0.0058
2833	Dihydrofolate reductase	Not Available	0.0058
2931	Dihydrofolate reductase	folA	0.0058
3544	Dihydrofolate reductase	folA	0.0058
3682	Dihydrofolate reductase	folA	0.0058
6642	Dihydrofolate reductase	folA	0.0058
6756	Dihydrofolate reductase	dfrA	0.0058
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0058
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0057
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
4122	Histone deacetylase 2	HDAC2	0.0055
6506	Stathmin-4	STMN4	0.0055
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
896	Glutathione S-transferase Mu 1	GSTM1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0052
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0052
6138	Multidrug resistance protein 3	ABCB4	0.0052
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0052
712	Tubulin alpha chain	TUB1	0.0052
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0052
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
6228	Nuclear receptor coactivator 1	NCOA1	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0051
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0051
293	Gamma-glutamyl hydrolase	GGH	0.005
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.005
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.005
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0049
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0049
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0049
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0049
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0049
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0049
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0049
714	Glutathione reductase, mitochondrial	GSR	0.0049
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0048
5626	Nucleoside diphosphate kinase B	NME2	0.0048
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0048
3810	Catechol O-methyltransferase	COMT	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
6241	Nuclear receptor coactivator 2	NCOA2	0.0047
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0047
6163	Copper-transporting ATPase 2	ATP7B	0.0047
6165	Copper-transporting ATPase 1	ATP7A	0.0047
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0047
24	Thymidylate synthase	TMP1	0.0047
359	Thymidylate synthase	TYMS	0.0047
2626	Thymidylate synthase	thyA	0.0047
2729	Thymidylate synthase	thyA	0.0047
5352	Thymidylate synthase	THYA	0.0047
3382	Glycolipid transfer protein	GLTP	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
814	Ryanodine receptor 1	RYR1	0.0046
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0045
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0045
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0045
737	Mineralocorticoid receptor	NR3C2	0.0045
6212	Tubulin gamma-1 chain	TUBG1	0.0045
6210	Tubulin delta chain	TUBD1	0.0045
6211	Tubulin epsilon chain	TUBE1	0.0045
6837	Serine/threonine-protein kinase 17B	STK17B	0.0044
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0044
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
489	Monocarboxylate transporter 2	SLC16A7	0.0044
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0044
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0042
1010	Cytochrome P450 51A1	CYP51A1	0.0042
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0042
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.004
3868	Calcineurin subunit B isoform 2	PPP3R2	0.004
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.004
856	Vitamin D3 receptor	VDR	0.004
342	P protein [Includes: DNA-directed DNA polymerase	P	0.004
612	P protein [Includes: DNA-directed DNA polymerase	P	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
2599	Tyrosine-protein kinase HCK	HCK	0.004
558	Solute carrier family 12 member 1	SLC12A1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
5294	Nucleoside diphosphate kinase A	NME1	0.004
469	Annexin A1	ANXA1	0.004
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.004
295	Carbonic anhydrase 1	CA1	0.0039
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0039
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0039
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
239	Coagulation factor X	F10	0.0039
357	Carbonic anhydrase 2	CA2	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
780	Retinoic acid receptor RXR-gamma	RXRG	0.0038
592	Carbonic anhydrase 4	CA4	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
3587	Gastrotropin	FABP6	0.0037
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0037
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0037
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0036
6044	Serum paraoxonase/lactonase 3	PON3	0.0036
702	UMP-CMP kinase	CMPK1	0.0036
4226	Uridine phosphorylase 2	UPP2	0.0036
7	Nitric oxide synthase, inducible	NOS2	0.0036
594	Thyroxine-binding globulin	SERPINA7	0.0036
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0036
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
88	Retinoic acid receptor RXR-beta	RXRB	0.0035
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0035
939	50S ribosomal protein L3	rplC	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0034
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0034
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
921	Glutamate receptor 2	GRIA2	0.0034
4225	Uridine phosphorylase 1	UPP1	0.0034
1192	Sulfotransferase 1A1	SULT1A1	0.0033
106	Cannabinoid receptor 2	CNR2	0.0033
3809	Estrogen-related receptor gamma	ESRRG	0.0033
758	Thyroid hormone receptor alpha	THRA	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
4217	Telomerase reverse transcriptase	TERT	0.0033
5818	Folate receptor alpha	FOLR1	0.0032
707	72 kDa type IV collagenase	MMP2	0.0032
6677	Myelin P2 protein	PMP2	0.0032
1867	Major prion protein	PRNP	0.0032
751	Potassium channel subfamily K member 6	KCNK6	0.0032
1714	Mitogen-activated protein kinase 3	MAPK3	0.0032
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0032
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0032
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0032
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0032
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0032
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0031
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0031
413	Amidophosphoribosyltransferase	PPAT	0.0031
2515	Amidophosphoribosyltransferase	purF	0.0031
3714	Amidophosphoribosyltransferase	purF	0.0031
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0031
6501	Fatty acid-binding protein, liver	FABP1	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
1992	Vitamin D-binding protein	GC	0.0031
427	Substance-P receptor	TACR1	0.0031
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.003
5934	Cytochrome P450 26A1	CYP26A1	0.003
518	Peroxidase/catalase T	katG	0.003
346	Thyroid hormone receptor beta-1	THRB	0.003
2021	Thrombomodulin	THBD	0.003
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.003
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.003
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4203	Histamine N-methyltransferase	HNMT	0.003
6168	Solute carrier family 22 member 16	SLC22A16	0.003
172	Potassium channel subfamily K member 1	KCNK1	0.0029
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0029
6103	Arylamine N-acetyltransferase 1	NAT1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0029
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0029
1760	Aminopeptidase N	ANPEP	0.0029
6843	Aminopeptidase N	pepN	0.0029
4311	tRNA	TRDMT1	0.0029
4325	tRNA	trmD	0.0029
4328	tRNA	trmD	0.0029
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0029
244	Angiotensin-converting enzyme	ACE	0.0029
3957	Adenosine deaminase	ADA	0.0029
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0028
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0028
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0028
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0028
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1525	Heparin-binding growth factor 2	FGF2	0.0028
6824	Tyrosine-protein kinase Lyn	LYN	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
65	Matrix metalloproteinase-9	Not Available	0.0028
6218	Pannexin-1	PANX1	0.0027
2216	Fibroblast growth factor receptor 4	FGFR4	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
4210	Toll-like receptor 4	TLR4	0.0026
229	Retinoic acid receptor beta	RARB	0.0026
2320	Thymidine kinase, cytosolic	TK1	0.0026
563	Thyroid peroxidase	TPO	0.0026
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0026
1648	Elastin	ELN	0.0026
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0026
162	Retinoic acid receptor gamma-1	RARG	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
49	Endothelin B receptor	EDNRB	0.0026
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0026
3639	Thymidine phosphorylase	deoA	0.0026
3936	Thymidine phosphorylase	TYMP	0.0026
730	Retinoic acid receptor alpha	RARA	0.0026
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0025
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0025
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
291	Nitric-oxide synthase, endothelial	NOS3	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
760	Fibroblast growth factor 1	FGF1	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
634	Squalene monooxygenase	SQLE	0.0025
7196	Squalene monooxygenase	ERG1	0.0025
3426	Glutamine synthetase	glnA	0.0025
3987	Glutamine synthetase	GLUL	0.0025
1313	Lactoylglutathione lyase	GLO1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
6231	Pepsin A	PGA3	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
174	Sigma 1-type opioid receptor	SIGMAR1	0.0024
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
484	Tyrosine-protein kinase ABL2	ABL2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0023
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0023
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0023
1291	cAMP response element-binding protein	CREB1	0.0023
3937	Fatty-acid amide hydrolase	FAAH	0.0023
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
6042	Prostaglandin reductase 2	PTGR2	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
3404	Exotoxin A	eta	0.0022
76	Nitric-oxide synthase, brain	NOS1	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
199	Monocarboxylate transporter 8	SLC16A2	0.0022
298	Renin	REN	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
2207	Rhodopsin	RHO	0.0021
1792	Tissue-type plasminogen activator	PLAT	0.0021
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0021
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0021
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
164	Histamine H4 receptor	HRH4	0.002
6126	Carbonic anhydrase 7	CA7	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
1820	Beta-nerve growth factor	NGF	0.002
1058	Cell division protein kinase 5	CDK5	0.002
822	Aldose reductase	AKR1B1	0.002
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0019
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
84	Nuclear receptor 0B1	NR0B1	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0019
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
153	Dopamine beta-hydroxylase	DBH	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
6151	Monocarboxylate transporter 10	SLC16A10	0.0018
4041	Microsomal glutathione S-transferase 2	MGST2	0.0018
976	Platelet glycoprotein IX	GP9	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
4103	Proteasome subunit beta type 2	PSMB2	0.0018
4102	Proteasome subunit beta type 5	PSMB5	0.0018
4101	Proteasome subunit beta type 1	PSMB1	0.0018
1374	Natriuretic peptides B	NPPB	0.0018
1827	Gap junction alpha-1 protein	GJA1	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1908	Vascular cell adhesion protein 1	VCAM1	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0017
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
1243	Cathepsin D	CTSD	0.0016
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0016
3616	Fatty acid-binding protein, epidermal	FABP5	0.0016
5431	Lipid binding protein	Not Available	0.0016
5433	UPF0230 protein TM_1468	TM_1468	0.0016
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0016
517	Alcohol dehydrogenase 1C	ADH1C	0.0016
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0016
1268	Neuropeptide S receptor	NPSR1	0.0016
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0016
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0016
3233	Bile acid receptor	NR1H4	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
6171	Solute carrier family 28 member 3	SLC28A3	0.0015
268	Adenosine A2b receptor	ADORA2B	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
4031	Glutathione S-transferase A1	GSTA1	0.0014
1541	Metalloproteinase	mmp20	0.0014
2391	Ferrochelatase	hemH	0.0014
6502	Ferrochelatase	DKFZp686P18130	0.0014
1591	Ferrochelatase, mitochondrial	FECH	0.0014
6073	Potassium channel subfamily K member 9	KCNK9	0.0014
6072	Potassium channel subfamily K member 3	KCNK3	0.0014
2240	Cell division protein kinase 2	CDK2	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6859	Protein S100-A4	S100A4	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
54	Prothrombin	F2	0.0013
283	SEC14-like protein 2	SEC14L2	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0013
6459	Glycodelin	PAEP	0.0013
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0013
1275	Estrogen sulfotransferase	SULT1E1	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0012
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0012
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0012
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0012
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0012
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0012
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0012
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0012
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0012
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0012
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0012
6559	Cytochrome c oxidase subunit 2	ctaC	0.0012
6669	Cytochrome c oxidase subunit 2	ctaC	0.0012
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0012
6558	Cytochrome c oxidase subunit 1	ctaD	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
2540	Choloylglycine hydrolase	cbh	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
319	Opioid receptor, sigma 1	OPRS1	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1630	Integrin beta-2	ITGB2	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
820	Glycine receptor subunit alpha-2	GLRA2	0.001
1928	Leukotriene C4 synthase	LTC4S	0.001
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.001
4034	Glutaredoxin-1	GLRX	0.001
910	Epididymal secretory glutathione peroxidase	GPX5	0.001
4036	Glutathione peroxidase 6	GPX6	0.001
4037	Hypothetical protein	GPX1	0.001
4297	Hypothetical protein	SP_1951	0.001
4521	Hypothetical protein	BC_2969	0.001
4540	Hypothetical protein	TM_1070	0.001
4555	Hypothetical protein	MT1739	0.001
4569	Hypothetical protein	mshD	0.001
4578	Hypothetical protein	PA3270	0.001
4747	Hypothetical protein	PA3967	0.001
5177	Hypothetical protein	TM_0096	0.001
5194	Hypothetical protein	PA1204	0.001
5240	Hypothetical protein	Rv2991	0.001
5370	Hypothetical protein	TM_1158	0.001
5710	Hypothetical protein	Tb927.5.1360	0.001
4029	Microsomal glutathione S-transferase 3	MGST3	0.001
900	Glutathione S-transferase A4	GSTA4	0.001
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.001
911	Glutathione peroxidase 3	GPX3	0.001
4040	Glutathione peroxidase 7	GPX7	0.001
907	Glutathione peroxidase 2	GPX2	0.001
4032	Microsomal glutathione S-transferase 1	MGST1	0.001
906	Glutathione peroxidase 1	GPX1	0.001
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.001
4035	Glutathione S-transferase Mu 5	GSTM5	0.001
903	Glutathione S-transferase A5	GSTA5	0.001
4042	Glutathione transferase omega-2	GSTO2	0.001
4033	S-formylglutathione hydrolase	ESD	0.001
4038	Glutathione peroxidase 4	GPX4	0.001
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.001
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0009
6500	Phospholipase A2	PLA2G1B	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
898	Glutathione S-transferase A3	GSTA3	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
897	Glutathione S-transferase kappa 1	GSTK1	0.0009
909	Maleylacetoacetate isomerase	GSTZ1	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
899	Glutathione S-transferase Mu 3	GSTM3	0.0008
905	Glutathione transferase omega-1	GSTO1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3830	Calreticulin	CALR	0.0008
2298	Cytochrome P450-cam	camC	0.0008
572	Integrin alpha-L	ITGAL	0.0008
2232	Interleukin-5	IL5	0.0008
2165	Glutathione S-transferase Mu 2	GSTM2	0.0008
1593	Mucin-2	MUC2	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
207	Glutathione synthetase	GSS	0.0008
5269	Glutathione synthetase	gshB	0.0008
1025	Aquaporin-1	AQP1	0.0008
1039	Histone deacetylase 9	HDAC9	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
901	Glutathione S-transferase Mu 4	GSTM4	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
125	DNA polymerase beta	POLB	0.0007
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0007
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0007
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
798	Osteocalcin	BGLAP	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
5961	Insulin	INS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
6755	Poliovirus receptor	PVR	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
4943	Cytochrome c6	petJ	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
5000	HemO	hemO	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
3116	Bacterioferritin	bfr	0.0004
4906	Bacterioferritin	bfr	0.0004
4965	Bacterioferritin	bfr	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4961	Hemophore HasA	hasA	0.0004
4909	CooA protein	cooA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4972	P450cin	cinA	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4952	Catalase/peroxidase	katA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
2616	Ganglioside GM2 activator	GM2A	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
2297	Genome polyprotein	Not Available	0.0004
2322	Genome polyprotein	Not Available	0.0004
2694	Genome polyprotein	Not Available	0.0004
2719	Genome polyprotein	Not Available	0.0004
2860	Genome polyprotein	Not Available	0.0004
2928	Genome polyprotein	Not Available	0.0004
3160	Genome polyprotein	Not Available	0.0004
3260	Genome polyprotein	Not Available	0.0004
4783	Genome polyprotein	Not Available	0.0004
5726	Genome polyprotein	Not Available	0.0004
5779	Genome polyprotein	Not Available	0.0004
5867	Genome polyprotein	Not Available	0.0004
6253	Genome polyprotein	Not Available	0.0004
6301	Genome polyprotein	Not Available	0.0004
6380	Genome polyprotein	Not Available	0.0004
6381	Genome polyprotein	Not Available	0.0004
6437	Genome polyprotein	Not Available	0.0004
6520	Genome polyprotein	Not Available	0.0004
6521	Genome polyprotein	Not Available	0.0004
6652	Genome polyprotein	Not Available	0.0004
6734	Genome polyprotein	Not Available	0.0004
6735	Genome polyprotein	Not Available	0.0004
6736	Genome polyprotein	Not Available	0.0004
6737	Genome polyprotein	Not Available	0.0004
6738	Genome polyprotein	Not Available	0.0004
6739	Genome polyprotein	Not Available	0.0004
6744	Genome polyprotein	Not Available	0.0004
6748	Genome polyprotein	Not Available	0.0004
6894	Genome polyprotein	Not Available	0.0004
6898	Genome polyprotein	Not Available	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
4920	Peroxidase/catalase	katG	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
2230	Catalase	CAT	0.0003
3249	Catalase	katA	0.0003
3625	Catalase	katA	0.0003
4539	Catalase	katA	0.0003
4941	Catalase	katB	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
3221	Cytochrome c4	cc4	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB08881 - Vemurafenib

Targets

Enzymes

Transporters

Carriers

Predictions