DT-Web: DB00201

Identification

Name

Caffeine

Accession Number

DB00201 (APRD00673)

Type

small molecule

Description

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes smooth muscle, stimulates cardiac muscle, stimulates diuresis, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide phosphodiesterases, antagonism of adenosine receptors, and modulation of intracellular calcium handling. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

194.1906

Groups

approved

Monoisotopic Weight

194.080375584

Pharmacology

Indication

For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.

Mechanism of action

Caffeine stimulates medullary, vagal, vasomotor, and respiratory centers, promoting bradycardia, vasoconstriction, and increased respiratory rate. This action was previously believed to be due primarily to increased intracellular cyclic 3′,5′-adenosine monophosphate (cyclic AMP) following inhibition of phosphodiesterase, the enzyme that degrades cyclic AMP. It is now thought that xanthines such as caffeine act as antagonists at adenosine-receptors within the plasma membrane of virtually every cell. As adenosine acts as an autocoid, inhibiting the release of neurotransmitters from presynaptic sites but augmenting the actions of norepinephrine or angiotensin, antagonism of adenosine receptors promotes neurotransmitter release. This explains the stimulatory effects of caffeine. Blockade of the adenosine A1 receptor in the heart leads to the accelerated, pronounced "pounding" of the heart upon caffeine intake.

Absorption

Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.

Protein binding

Low (25 to 36%).

Biotransformation

Hepatic cytochrome P450 1A2 (CYP 1A2) is involved in caffeine biotransformation. About 80% of a dose of caffeine is metabolized to paraxanthine (1,7-dimethylxanthine), 10% to theobromine (3,7-dimethylxanthine), and 4% to theophylline (1,3-dimethylxanthine).

Route of elimination

In young infants, the elimination of caffeine is much slower than that in adults due to immature hepatic and/or renal function.

Toxicity

LD₅₀=127 mg/kg (orally in mice)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Adenosine	Caffeine may diminish the therapeutic effect of adenosine. Specific management recommendations vary slightly depending on specific adenosine product used (i.e., therapeutic vs. diagnostic use of adenosine). Significantly higher adenosine doses, or alternative agents, may be required. Monitor for decreased therapeutic effects of adenosine if the patient is already receiving caffeine. Discontinue caffeine in advance (5 half-lives, or approximately 24 hours, is specifically recommended) of scheduled diagnostic use of adenosine (e.g., for radionuclide imaging studies) whenever possible.
Ciprofloxacin	Ciprofloxacin may increase the effect and toxicity of caffeine.
Clozapine	Caffeine increases the effect and toxicity of clozapine
Conivaptan	Conivaptan may increase the serum concentration of CYP3A4 substrates such as caffeine. Upon completion/discontinuation of conivaptan, allow at least 7 days before initiating therapy with drugs that are CYP3A4 substrates.
Grepafloxacin	Grepafloxacin may increase the effect and toxicity of caffeine.
Lithium	Caffeine decreases serum levels of lithium
Norfloxacin	Norfloxacin may increase the effect and toxicity of caffeine.
Regadenoson	Caffeine may diminish the vasodilatory effect of Regadenoson. Regadenoson prescribing information recommends avoiding using caffeine or other methylxanthine containing products (e.g., theophylline) for at least 12 hours prior the the administration of regadenoson. The impact of low doses of caffeine-containing products such as coffee, tea, and colas is unclear.
Tamsulosin	Caffeine, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Caffeine is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine may increase the plasma concentration of Caffeine.
Thiabendazole	The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Caffeine by decreasing Caffeine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Caffeine if Thiabendazole is initiated, discontinued or dose changed.
Tolterodine	Caffeine may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Vemurafenib	Vemurafenib increases the AUC of caffeine (CYP1A2 substrate) 2.6-fold.

Food Interactions

Not Available

Adenosine A1 receptor
Name	Adenosine A1 receptor
Gene Name	ADORA1
Pharmacological action	yes
Actions	antagonist,multitarget
References	Gaytan SP, Saadani-Makki F, Bodineau L, Frugiere A, Larnicol N, Pasaro R: Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem. Auton Neurosci. 2006 Jun 30;126-127:339-46. Epub 2006 May 15. - Pubmed Wang SJ: Caffeine facilitation of glutamate release from rat cerebral cortex nerve terminals (synaptosomes) through activation protein kinase C pathway: an interaction with presynaptic adenosine A1 receptors. Synapse. 2007 Jun;61(6):401-11. - Pubmed Rieg T, Schnermann J, Vallon V: Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite. Eur J Pharmacol. 2007 Jan 26;555(2-3):174-7. Epub 2006 Oct 25. - Pubmed Mustafa S, Venkatesh P, Pasha K, Mullangi R, Srinivas NR: Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF? Xenobiotica. 2006 Dec;36(12):1239-58. - Pubmed Listos J, Malec D, Fidecka S: Adenosine receptor antagonists intensify the benzodiazepine withdrawal signs in mice. Pharmacol Rep. 2006 Sep-Oct;58(5):643-51. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.5009
Adenosine A2a receptor
Name	Adenosine A2a receptor
Gene Name	ADORA2A
Pharmacological action	yes
Actions	antagonist,multitarget
References	Riksen NP, Franke B, van den Broek P, Smits P, Rongen GA: The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. Pharmacogenet Genomics. 2007 Jul;17(7):551-4. - Pubmed Zhao G, Messina E, Xu X, Ochoa M, Sun HL, Leung K, Shryock J, Belardinelli L, Hintze TH: Caffeine attenuates the duration of coronary vasodilation and changes in hemodynamics induced by regadenoson (CVT-3146), a novel adenosine A2A receptor agonist. J Cardiovasc Pharmacol. 2007 Jun;49(6):369-75. - Pubmed Cornelis MC, El-Sohemy A, Campos H: Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. Am J Clin Nutr. 2007 Jul;86(1):240-4. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.7517
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Name	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Gene Name	PDE4B
Pharmacological action	unknown
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Daly JW: Caffeine analogs: biomedical impact. Cell Mol Life Sci. 2007 Aug;64(16):2153-69. - Pubmed
DTHybrid score	Not Available
Ryanodine receptor 1
Name	Ryanodine receptor 1
Gene Name	RYR1
Pharmacological action	unknown
Actions	Not Available
References	Daly JW: Caffeine analogs: biomedical impact. Cell Mol Life Sci. 2007 Aug;64(16):2153-69. - Pubmed
DTHybrid score	0.3924

Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.5305
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate,inhibitor
References	Brosen K: Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet. 1995;29 Suppl 1:20-5. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Hickman D, Wang JP, Wang Y, Unadkat JD: Evaluation of the selectivity of In vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities. Drug Metab Dispos. 1998 Mar;26(3):207-15. - Pubmed
DTHybrid score	0.6997
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4118
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.011
Cytochrome P450 2E1
Name	Cytochrome P450 2E1
Gene Name	CYP2E1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4476
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4884
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6193
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.406
Cytochrome P450 1B1
Name	Cytochrome P450 1B1
Gene Name	CYP1B1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2426
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6654

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate,inhibitor
References	Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR: Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar;16(3):408-14. - Pubmed Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. - Pubmed
DTHybrid score	0.5767

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.4298
6030	Cytochrome P450 2B6	CYP2B6	0.2551
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.255
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.2221
268	Adenosine A2b receptor	ADORA2B	0.2187
5718	Cytochrome P450 2A6	CYP2A6	0.17
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1647
587	Serum albumin	ALB	0.1316
20	Prostaglandin G/H synthase 1	PTGS1	0.1221
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.1176
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.109
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.1003
492	Histamine H1 receptor	HRH1	0.0997
4122	Histone deacetylase 2	HDAC2	0.0975
862	Multidrug resistance-associated protein 1	ABCC1	0.0958
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0934
6106	Cytochrome P450 2C18	CYP2C18	0.0898
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0884
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0869
3811	Cytochrome P450 19A1	CYP19A1	0.0837
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0816
390	Adenosine A3 receptor	ADORA3	0.08
6143	Solute carrier family 22 member 7	SLC22A7	0.0797
824	Sodium-dependent serotonin transporter	SLC6A4	0.0796
6145	Solute carrier family 22 member 1	SLC22A1	0.0756
776	Bile salt export pump	ABCB11	0.0716
831	D(2) dopamine receptor	DRD2	0.0715
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0701
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0697
290	Prostaglandin G/H synthase 2	PTGS2	0.069
1729	Solute carrier family 22 member 6	SLC22A6	0.0677
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0676
556	Alpha-1A adrenergic receptor	ADRA1A	0.067
6144	Solute carrier family 22 member 2	SLC22A2	0.0635
1830	5'-nucleotidase	NT5E	0.0617
691	cAMP-specific 3',5'-cyclic phosphodiesterase 7B	PDE7B	0.0582
4165	P2Y purinoceptor 2	P2RY2	0.0581
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.058
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0573
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0569
136	Estrogen receptor	ESR1	0.0566
847	Mu-type opioid receptor	OPRM1	0.0559
430	Follicle-stimulating hormone receptor	FSHR	0.0539
318	Alpha-2A adrenergic receptor	ADRA2A	0.0535
779	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	PDE7A	0.0534
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0529
871	Glucocorticoid receptor	NR3C1	0.0525
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0524
3957	Adenosine deaminase	ADA	0.0521
766	Beta-2 adrenergic receptor	ADRB2	0.051
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0503
6031	Cytochrome P450 3A43	CYP3A43	0.05
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0497
777	Tumor necrosis factor	TNF	0.0487
468	Cytochrome P450 4A11	CYP4A11	0.0486
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0483
193	Beta-1 adrenergic receptor	ADRB1	0.0481
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.048
817	DNA topoisomerase 2-alpha	TOP2A	0.0476
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0475
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0466
23	D(1A) dopamine receptor	DRD1	0.0462
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0461
2654	Complement control protein	C3L	0.046
590	5-hydroxytryptamine 2C receptor	HTR2C	0.046
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0458
118	Organic cation/carnitine transporter 2	SLC22A5	0.0453
723	Cytosolic phospholipase A2	PLA2G4A	0.0441
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0439
632	Alpha-1B adrenergic receptor	ADRA1B	0.043
5455	Arylsulfatase A	ARSA	0.0424
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0423
467	Delta-type opioid receptor	OPRD1	0.0422
6147	Solute carrier family 22 member 3	SLC22A3	0.0418
6021	Adenosine kinase	ADK	0.0416
6142	Solute carrier family 22 member 8	SLC22A8	0.0415
2684	Histidine triad nucleotide-binding protein 1	HINT1	0.0408
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0408
260	Cytochrome P450 51	ERG11	0.0404
761	Cytochrome P450 51	ERG11	0.0404
3163	Cytochrome P450 51	cyp51	0.0404
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0398
713	Sodium-dependent dopamine transporter	SLC6A3	0.0398
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0394
696	Kappa-type opioid receptor	OPRK1	0.0392
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0392
2164	Multidrug resistance-associated protein 4	ABCC4	0.039
3941	Amine oxidase [flavin-containing] A	MAOA	0.039
3947	Xanthine dehydrogenase/oxidase	XDH	0.0389
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0387
465	Calmodulin	CALM1	0.0386
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0386
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0385
6148	Multidrug resistance-associated protein 7	ABCC10	0.0383
6171	Solute carrier family 28 member 3	SLC28A3	0.0379
638	D(3) dopamine receptor	DRD3	0.0378
731	HIV-1 protease	HIV-1 protease	0.0375
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0368
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0356
274	Muscarinic acetylcholine receptor M5	CHRM5	0.035
3923	Cholinesterase	BCHE	0.0349
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0348
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0341
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0341
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.034
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.034
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0335
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0334
833	Organic cation/carnitine transporter 1	SLC22A4	0.0324
54	Prothrombin	F2	0.0321
6182	Cytochrome P450 2J2	CYP2J2	0.0317
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0315
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0305
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0303
629	Alpha-2B adrenergic receptor	ADRA2B	0.0289
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0285
6220	Aryl hydrocarbon receptor	AHR	0.0278
789	Alpha-1D adrenergic receptor	ADRA1D	0.0276
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0276
3939	Amine oxidase [flavin-containing] B	MAOB	0.0276
614	Progesterone receptor	PGR	0.0275
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0275
844	Epidermal growth factor receptor	EGFR	0.0274
378	Alpha-2C adrenergic receptor	ADRA2C	0.0272
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0269
146	Androgen receptor	AR	0.026
36	Insulin receptor	INSR	0.0258
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0254
477	DNA topoisomerase 4 subunit A	parC	0.0253
886	DNA topoisomerase 4 subunit A	parC	0.0253
6226	DNA topoisomerase 4 subunit A	parC	0.0253
474	Acetylcholinesterase	ACHE	0.0252
404	DNA gyrase subunit A	gyrA	0.0249
6224	DNA gyrase subunit A	gyrA	0.0249
504	Mast/stem cell growth factor receptor	KIT	0.0243
380	Cytochrome P450 17A1	CYP17A1	0.0242
122	P2Y purinoceptor 12	P2RY12	0.0242
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0242
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0242
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.024
432	D(4) dopamine receptor	DRD4	0.024
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.024
737	Mineralocorticoid receptor	NR3C2	0.0239
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0235
6014	Cytochrome P450 2A13	CYP2A13	0.0234
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0234
1010	Cytochrome P450 51A1	CYP51A1	0.0231
4604	Liver carboxylesterase 1	CES1	0.023
6141	Sodium/bile acid cotransporter	SLC10A1	0.0227
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0226
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0223
811	Translocator protein	TSPO	0.0223
1024	Solute carrier family 22 member 11	SLC22A11	0.0222
29	Tubulin beta-1 chain	TUBB1	0.0221
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.022
756	Sex hormone-binding globulin	SHBG	0.0218
6137	Multidrug resistance-associated protein 6	ABCC6	0.0217
1757	Myeloperoxidase	MPO	0.0215
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0213
4203	Histamine N-methyltransferase	HNMT	0.021
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.021
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0203
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0203
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0202
869	Estrogen receptor beta	ESR2	0.0202
4120	NADPH--cytochrome P450 reductase	POR	0.0202
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0199
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0197
891	Dihydropteroate synthase	folP	0.0196
5359	Dihydropteroate synthase	folP	0.0196
7175	Dihydropteroate synthase	sulI	0.0196
4228	Keratin, type II cytoskeletal 7	KRT7	0.0194
94	5-hydroxytryptamine 4 receptor	HTR4	0.0191
6102	Arylamine N-acetyltransferase 2	NAT2	0.0187
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0186
70	Type-1 angiotensin II receptor	AGTR1	0.0185
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0185
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0184
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0183
6136	Multidrug resistance-associated protein 5	ABCC5	0.0183
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0181
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0179
613	Atrial natriuretic peptide receptor A	NPR1	0.0179
716	5-hydroxytryptamine 7 receptor	HTR7	0.0178
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0177
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0177
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0176
1192	Sulfotransferase 1A1	SULT1A1	0.0174
144	Hemoglobin subunit alpha	HBA1	0.0173
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0173
273	Apoptosis regulator Bcl-2	BCL2	0.0172
373	Transthyretin	TTR	0.0171
232	Corticosteroid-binding globulin	SERPINA6	0.0166
407	Vascular endothelial growth factor receptor 2	KDR	0.0164
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0164
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0162
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0162
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0162
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0162
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0162
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0162
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0161
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.016
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0158
26	Vascular endothelial growth factor receptor 3	FLT4	0.0157
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0156
1852	Microtubule-associated protein 2	MAP2	0.0156
124	Histamine H2 receptor	HRH2	0.0154
818	50S ribosomal protein L10	rplJ	0.0152
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0152
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0152
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0152
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0152
161	Tubulin beta chain	TUBB	0.0151
312	Tubulin beta chain	TUB2	0.0151
32	Vascular endothelial growth factor receptor 1	FLT1	0.015
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.015
1517	Beta-3 adrenergic receptor	ADRB3	0.0149
2449	Tubulin alpha-3 chain	TUBA1A	0.0148
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0148
952	Dipeptidyl peptidase 4	DPP4	0.0148
1629	Transcription factor AP-1	JUN	0.0147
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0147
2499	Tubulin beta-2C chain	TUBB2C	0.0144
5923	Microtubule-associated protein tau	MAPT	0.0141
5924	Microtubule-associated protein 4	MAP4	0.0141
705	Glutamate receptor 1	GRIA1	0.0141
163	D(1B) dopamine receptor	DRD5	0.0139
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0138
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0138
571	Melatonin receptor type 1A	MTNR1A	0.0137
362	Melatonin receptor type 1B	MTNR1B	0.0137
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0135
365	Dihydrofolate reductase	DHFR	0.0134
2381	Dihydrofolate reductase	DFR1	0.0134
2833	Dihydrofolate reductase	Not Available	0.0134
2931	Dihydrofolate reductase	folA	0.0134
3544	Dihydrofolate reductase	folA	0.0134
3682	Dihydrofolate reductase	folA	0.0134
6642	Dihydrofolate reductase	folA	0.0134
6756	Dihydrofolate reductase	dfrA	0.0134
482	Glycine receptor subunit alpha-1	GLRA1	0.0133
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0132
427	Substance-P receptor	TACR1	0.0131
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0131
4116	Dihydropteroate synthetase	Not Available	0.0131
295	Carbonic anhydrase 1	CA1	0.0129
3932	Glutathione S-transferase A2	GSTA2	0.0129
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0129
790	DNA polymerase subunit alpha B	POLA2	0.0129
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0128
6020	Aldehyde oxidase	AOX1	0.0127
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0126
2112	Toll-like receptor 9	TLR9	0.0126
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0124
1656	CYP2B protein	CYP2B	0.0124
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0124
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0122
605	Fumarate reductase flavoprotein subunit	frdA	0.0121
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0121
3673	Fumarate reductase flavoprotein subunit	fccA	0.0121
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0121
6549	Fumarate reductase flavoprotein subunit	frdA	0.0121
442	Envelope glycoprotein	gp41	0.012
4859	Envelope glycoprotein	env	0.012
469	Annexin A1	ANXA1	0.012
84	Nuclear receptor 0B1	NR0B1	0.0119
48	Pyridoxal kinase	PDXK	0.0116
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0116
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0116
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
6085	Fatty acid-binding protein, intestinal	FABP2	0.0115
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0114
24	Thymidylate synthase	TMP1	0.0114
359	Thymidylate synthase	TYMS	0.0114
2626	Thymidylate synthase	thyA	0.0114
2729	Thymidylate synthase	thyA	0.0114
5352	Thymidylate synthase	THYA	0.0114
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.0113
1050	Bile salt sulfotransferase	SULT2A1	0.0111
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0111
6146	High affinity copper uptake protein 1	SLC31A1	0.011
823	Fibroblast growth factor receptor 2	FGFR2	0.0109
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0109
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0109
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0109
1714	Mitogen-activated protein kinase 3	MAPK3	0.0109
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0109
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0108
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0107
904	Glutathione S-transferase P	GSTP1	0.0107
4237	50S ribosomal protein L22	rplV	0.0106
6766	O-GlcNAcase BT_4395	BT_4395	0.0105
3810	Catechol O-methyltransferase	COMT	0.0105
527	Prostacyclin receptor	PTGIR	0.0105
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0104
738	Monocarboxylate transporter 1	SLC16A1	0.0103
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0103
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0103
592	Carbonic anhydrase 4	CA4	0.0101
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0101
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0101
4311	tRNA	TRDMT1	0.01
4325	tRNA	trmD	0.01
4328	tRNA	trmD	0.01
5251	Carbonyl reductase [NADPH] 1	CBR1	0.01
768	FK506-binding protein 1A	FKBP1A	0.01
275	Arachidonate 5-lipoxygenase	ALOX5	0.0099
921	Glutamate receptor 2	GRIA2	0.0099
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0099
4192	DNA topoisomerase 2-beta	TOP2B	0.0099
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0098
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0097
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0097
239	Coagulation factor X	F10	0.0097
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
165	FL cytokine receptor	FLT3	0.0096
88	Retinoic acid receptor RXR-beta	RXRB	0.0095
976	Platelet glycoprotein IX	GP9	0.0095
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0095
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0095
4238	50S ribosomal protein L4	rplD	0.0094
5578	50S ribosomal protein L4	rplD	0.0094
6173	50S ribosomal protein L4	rplD	0.0094
6219	50S ribosomal protein L4	rplD	0.0094
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0094
1569	G1/S-specific cyclin-D1	CCND1	0.0094
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0094
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0094
908	Glutathione S-transferase theta-1	GSTT1	0.0093
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0093
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0092
319	Opioid receptor, sigma 1	OPRS1	0.0091
5934	Cytochrome P450 26A1	CYP26A1	0.0091
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0091
2539	Tubulin alpha-1 chain	TUBA4A	0.009
153	Dopamine beta-hydroxylase	DBH	0.0089
33	Cystine/glutamate transporter	SLC7A11	0.0089
2236	Casein kinase II subunit alpha	CSNK2A1	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0088
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
131	Synaptic vesicular amine transporter	SLC18A2	0.0086
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0086
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0086
6138	Multidrug resistance protein 3	ABCB4	0.0086
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0085
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0085
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0085
936	Ephrin type-A receptor 2	EPHA2	0.0084
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0084
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0084
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0084
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0083
1176	Mitogen-activated protein kinase 1	MAPK1	0.0083
6216	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	PDE8A	0.0083
780	Retinoic acid receptor RXR-gamma	RXRG	0.0082
6217	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	PDE8B	0.0081
1275	Estrogen sulfotransferase	SULT1E1	0.0081
6126	Carbonic anhydrase 7	CA7	0.0081
565	Extracellular calcium-sensing receptor	CASR	0.008
68	Cannabinoid receptor 1	CNR1	0.008
1353	DNA topoisomerase 1	TOP1	0.008
3552	DNA topoisomerase 1	topA	0.008
7	Nitric oxide synthase, inducible	NOS2	0.0079
3937	Fatty-acid amide hydrolase	FAAH	0.0079
173	Toll-like receptor 7	TLR7	0.0079
1792	Tissue-type plasminogen activator	PLAT	0.0079
3830	Calreticulin	CALR	0.0078
284	DNA-directed RNA polymerase beta chain	rpoB	0.0078
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0078
1618	High affinity nerve growth factor receptor	NTRK1	0.0078
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0077
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0077
174	Sigma 1-type opioid receptor	SIGMAR1	0.0077
518	Peroxidase/catalase T	katG	0.0076
244	Angiotensin-converting enzyme	ACE	0.0076
820	Glycine receptor subunit alpha-2	GLRA2	0.0076
357	Carbonic anhydrase 2	CA2	0.0076
5300	Antigen peptide transporter 1	TAP1	0.0075
6044	Serum paraoxonase/lactonase 3	PON3	0.0075
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0075
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0075
444	Alcohol dehydrogenase 1B	ADH1B	0.0075
4103	Proteasome subunit beta type 2	PSMB2	0.0074
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0074
4102	Proteasome subunit beta type 5	PSMB5	0.0074
4101	Proteasome subunit beta type 1	PSMB1	0.0074
1541	Metalloproteinase	mmp20	0.0074
3809	Estrogen-related receptor gamma	ESRRG	0.0074
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0074
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0074
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0073
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0073
6034	Hydroxyindole O-methyltransferase	ASMT	0.0073
6035	Nuclear receptor ROR-beta	RORB	0.0073
6036	Eosinophil peroxidase	EPX	0.0073
6043	Putative G-protein coupled receptor 44	GPR44	0.0072
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0072
251	Alcohol dehydrogenase 1A	ADH1A	0.0072
1483	Membrane copper amine oxidase	AOC3	0.0072
183	Vascular endothelial growth factor A	VEGFA	0.0072
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0071
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0071
1291	cAMP response element-binding protein	CREB1	0.007
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.007
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.007
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.007
177	Biotin--protein ligase	HLCS	0.007
690	Acetyl-CoA carboxylase 1	ACACA	0.007
484	Tyrosine-protein kinase ABL2	ABL2	0.007
162	Retinoic acid receptor gamma-1	RARG	0.007
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.007
49	Endothelin B receptor	EDNRB	0.0069
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0069
3601	Dihydropteroate synthase 1	folP1	0.0069
3807	Dihydropteroate synthase 1	folP1	0.0069
3808	Dihydropteroate synthase 2	folP2	0.0069
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0068
634	Squalene monooxygenase	SQLE	0.0068
7196	Squalene monooxygenase	ERG1	0.0068
3086	Plasmepsin-2	Not Available	0.0068
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0067
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0067
1196	Complement decay-accelerating factor	CD55	0.0067
856	Vitamin D3 receptor	VDR	0.0067
5691	DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC	rmlC	0.0067
3361	Serpin B5	SERPINB5	0.0067
5694	Transcription antiterminator licT	licT	0.0067
3856	Fibroblast growth factor receptor 3	FGFR3	0.0066
6163	Copper-transporting ATPase 2	ATP7B	0.0066
6165	Copper-transporting ATPase 1	ATP7A	0.0066
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0065
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0065
6432	Transporter	snf	0.0065
164	Histamine H4 receptor	HRH4	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0065
1820	Beta-nerve growth factor	NGF	0.0064
765	Indoleamine 2,3-dioxygenase	IDO1	0.0063
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0063
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
1648	Elastin	ELN	0.0063
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
133	Dihydropterate synthase	sulI	0.0063
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
4773	Deoxycytidine kinase	DCK	0.0062
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0061
1374	Natriuretic peptides B	NPPB	0.0061
1827	Gap junction alpha-1 protein	GJA1	0.0061
1908	Vascular cell adhesion protein 1	VCAM1	0.0061
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0061
896	Glutathione S-transferase Mu 1	GSTM1	0.006
581	Cytochrome P450 2R1	CYP2R1	0.006
564	Cellular retinoic acid-binding protein 1	CRABP1	0.006
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0059
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
2808	Chloramphenicol acetyltransferase 3	cat3	0.0058
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0058
5880	Thrombopoietin receptor	MPL	0.0058
1630	Integrin beta-2	ITGB2	0.0058
6174	50S ribosomal protein L32	rpmF	0.0058
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0058
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0058
517	Alcohol dehydrogenase 1C	ADH1C	0.0058
569	Retinal dehydrogenase 2	ALDH1A2	0.0057
3913	Glutamic acid decarboxylase	GAD65	0.0057
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0057
771	Pyruvate carboxylase, mitochondrial	PC	0.0056
563	Thyroid peroxidase	TPO	0.0055
751	Potassium channel subfamily K member 6	KCNK6	0.0055
6506	Stathmin-4	STMN4	0.0055
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0055
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0055
992	Protein tyrosine kinase 2 beta	PTK2B	0.0054
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0054
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0054
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0054
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0054
106	Cannabinoid receptor 2	CNR2	0.0054
611	Retinal dehydrogenase 1	ALDH1A1	0.0053
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0053
2417	Chloramphenicol acetyltransferase	cat	0.0053
3278	Chloramphenicol acetyltransferase	cat	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
2810	Dr hemagglutinin structural subunit	draA	0.0052
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0052
719	Retinoic acid receptor responder protein 1	RARRES1	0.0052
770	Retinoic acid-induced protein 3	GPRC5A	0.0052
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0052
712	Tubulin alpha chain	TUB1	0.0052
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0052
775	Acetyl-CoA carboxylase 2	ACACB	0.0052
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
3823	Cytokine receptor common gamma chain	IL2RG	0.0051
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0051
2286	Isocitrate dehydrogenase [NADP]	icd	0.0051
2302	Isocitrate dehydrogenase [NADP]	icd	0.0051
2771	Isocitrate dehydrogenase [NADP]	icd	0.0051
172	Potassium channel subfamily K member 1	KCNK1	0.0051
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.005
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.005
6048	Troponin C, skeletal muscle	TNNC2	0.005
851	5'-AMP-activated protein kinase subunit beta-2	PRKAB2	0.0049
388	AMP deaminase 1	AMPD1	0.0049
3404	Exotoxin A	eta	0.0049
4534	Cytohesin-2	CYTH2	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
3904	Alanine aminotransferase 2	GPT2	0.0048
735	Alanine aminotransferase 1	GPT	0.0048
1992	Vitamin D-binding protein	GC	0.0047
3668	Maltose-binding periplasmic protein precursor	malE	0.0047
5787	Angiopoietin-1 receptor	TEK	0.0047
2616	Ganglioside GM2 activator	GM2A	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1525	Heparin-binding growth factor 2	FGF2	0.0046
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0046
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0046
2230	Catalase	CAT	0.0046
3249	Catalase	katA	0.0046
3625	Catalase	katA	0.0046
4539	Catalase	katA	0.0046
4941	Catalase	katB	0.0046
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0046
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0046
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0046
267	Plasminogen activator inhibitor 1	SERPINE1	0.0046
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0045
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0045
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0045
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0045
297	Adenylate cyclase type 1	ADCY1	0.0045
6824	Tyrosine-protein kinase Lyn	LYN	0.0045
724	Interleukin-2 receptor alpha chain	IL2RA	0.0045
717	Interleukin-2 receptor subunit beta	IL2RB	0.0045
2178	Metabotropic glutamate receptor 5	GRM5	0.0045
130	Prostacyclin synthase	PTGIS	0.0044
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0044
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0044
572	Integrin alpha-L	ITGAL	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
473	L-lactate dehydrogenase A chain	LDHA	0.0042
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0042
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0042
2592	Beta-galactosidase	lacZ	0.0042
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0042
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0041
229	Retinoic acid receptor beta	RARB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6221	Steroid hormone receptor ERR1	ESRRA	0.0041
1864	RET proto-oncogene	RET	0.0041
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.004
65	Matrix metalloproteinase-9	Not Available	0.004
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.004
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.004
730	Retinoic acid receptor alpha	RARA	0.004
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
315	Arginase-1	ARG1	0.004
3426	Glutamine synthetase	glnA	0.0039
3987	Glutamine synthetase	GLUL	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0039
2290	ADP-ribosyl cyclase 2	BST1	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
128	Adenine phosphoribosyltransferase	APRT	0.0038
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0038
4198	Fructose-1,6-bisphosphatase 1	FBP1	0.0038
594	Thyroxine-binding globulin	SERPINA7	0.0037
400	Coagulation factor IX	F9	0.0037
5461	Coagulation factor IX	F9	0.0037
6103	Arylamine N-acetyltransferase 1	NAT1	0.0037
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
558	Solute carrier family 12 member 1	SLC12A1	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
2216	Fibroblast growth factor receptor 4	FGFR4	0.0035
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0035
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
1262	Corticotropin-lipotropin	POMC	0.0035
10	Glycogen phosphorylase, liver form	PYGL	0.0035
291	Nitric-oxide synthase, endothelial	NOS3	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0035
758	Thyroid hormone receptor alpha	THRA	0.0034
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0034
604	Vitamin K-dependent protein Z	PROZ	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0034
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0034
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0034
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0033
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0033
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0032
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0032
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0032
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0032
6168	Solute carrier family 22 member 16	SLC22A16	0.0032
6131	Carbonic anhydrase 14	CA14	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
3090	Chitosanase	csn	0.0031
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
422	Vitamin K-dependent protein C	PROC	0.0031
1245	Vitamin K-dependent protein S	PROS1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0031
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0031
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0031
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0031
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0031
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0031
346	Thyroid hormone receptor beta-1	THRB	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
3639	Thymidine phosphorylase	deoA	0.003
3936	Thymidine phosphorylase	TYMP	0.003
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1650	Heme carrier protein 1	SLC46A1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
2599	Tyrosine-protein kinase HCK	HCK	0.003
6122	Carbonic anhydrase 3	CA3	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0029
2298	Cytochrome P450-cam	camC	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
233	Potassium channel subfamily K member 2	KCNK2	0.0029
6459	Glycodelin	PAEP	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
1253	Interferon gamma	IFNG	0.0028
330	Spermidine synthase	SRM	0.0028
3038	Spermidine synthase	speE	0.0028
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
199	Monocarboxylate transporter 8	SLC16A2	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0027
4210	Toll-like receptor 4	TLR4	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0027
2207	Rhodopsin	RHO	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
2408	Tyrosine-protein kinase SYK	SYK	0.0026
4217	Telomerase reverse transcriptase	TERT	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0026
6859	Protein S100-A4	S100A4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
798	Osteocalcin	BGLAP	0.0025
358	Cystathionine beta-synthase	CBS	0.0025
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0025
1039	Histone deacetylase 9	HDAC9	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6070	Nischarin	NISCH	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
760	Fibroblast growth factor 1	FGF1	0.0024
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0023
4226	Uridine phosphorylase 2	UPP2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0023
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
369	Coagulation factor VII	F7	0.0023
822	Aldose reductase	AKR1B1	0.0023
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0023
76	Nitric-oxide synthase, brain	NOS1	0.0022
707	72 kDa type IV collagenase	MMP2	0.0022
113	S-adenosylmethionine decarboxylase proenzyme	AMD1	0.0022
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0022
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0022
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0022
411	Glycine N-methyltransferase	GNMT	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
2232	Interleukin-5	IL5	0.0022
997	Protein kinase C beta type	PRKCB	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
4225	Uridine phosphorylase 1	UPP1	0.0021
2300	Lysozyme	E	0.0021
3633	Lysozyme	R	0.0021
5597	Lysozyme	17	0.0021
489	Monocarboxylate transporter 2	SLC16A7	0.0021
2091	Endoplasmin	HSP90B1	0.0021
3007	Carbonic anhydrase 12	CA12	0.0021
4205	Carbonic anhydrase 9	CA9	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
1268	Neuropeptide S receptor	NPSR1	0.0021
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0021
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0021
3221	Cytochrome c4	cc4	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
5798	Mitogen-activated protein kinase 11	MAPK11	0.0021
828	Phenylalanine-4-hydroxylase	PAH	0.0021
3109	Phenylalanine-4-hydroxylase	phhA	0.0021
2320	Thymidine kinase, cytosolic	TK1	0.002
413	Amidophosphoribosyltransferase	PPAT	0.002
2515	Amidophosphoribosyltransferase	purF	0.002
3714	Amidophosphoribosyltransferase	purF	0.002
293	Gamma-glutamyl hydrolase	GGH	0.002
1970	Protein kinase C alpha type	PRKCA	0.002
5433	UPF0230 protein TM_1468	TM_1468	0.002
3616	Fatty acid-binding protein, epidermal	FABP5	0.002
5431	Lipid binding protein	Not Available	0.002
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
718	Folate receptor gamma	FOLR3	0.0019
299	Folate receptor beta	FOLR2	0.0019
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0019
6073	Potassium channel subfamily K member 9	KCNK9	0.0019
6072	Potassium channel subfamily K member 3	KCNK3	0.0019
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0019
2021	Thrombomodulin	THBD	0.0019
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
6218	Pannexin-1	PANX1	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
283	SEC14-like protein 2	SEC14L2	0.0017
6151	Monocarboxylate transporter 10	SLC16A10	0.0017
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0016
6837	Serine/threonine-protein kinase 17B	STK17B	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
1243	Cathepsin D	CTSD	0.0016
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0016
2211	Fatty acid-binding protein, heart	FABP3	0.0016
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
3238	Multidrug resistance protein mexA	mexA	0.0016
3709	Glycerol uptake facilitator protein	glpF	0.0016
3116	Bacterioferritin	bfr	0.0016
4906	Bacterioferritin	bfr	0.0016
4965	Bacterioferritin	bfr	0.0016
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0016
3173	Enolase	eno	0.0016
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0016
3393	TGF-beta receptor type-2	TGFBR2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6755	Poliovirus receptor	PVR	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
6677	Myelin P2 protein	PMP2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0014
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
2852	DNA mismatch repair protein mutL	mutL	0.0014
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0014
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
3191	Histidinol dehydrogenase	hisD	0.0013
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0013
6228	Nuclear receptor coactivator 1	NCOA1	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
4692	A/G-specific adenine glycosylase	mutY	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
85	Growth hormone receptor	GHR	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0012
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0012
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2802	Endoglucanase G	celCCG	0.0011
6316	ADP-ribosylation factor 1	ARF1	0.0011
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.001
345	Plasma retinol-binding protein	RBP4	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
4948	Cytochrome c-553	Not Available	0.001
4923	Cytochrome c3	DvMF_2499	0.001
4945	Cytochrome c3	Not Available	0.001
4949	Cytochrome c3	DVU_3171	0.001
4968	Cytochrome c3	cytc3	0.001
4997	Cytochrome c3	SO_2727	0.001
5219	Cytochrome c3	cyd	0.001
4902	Nine-heme cytochrome c	Ddes_2038	0.001
3189	High-molecular-weight cytochrome c	hmcA	0.001
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.001
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4386	Hemoglobin-like protein HbN	glbN	0.0008
1867	Major prion protein	PRNP	0.0008
6042	Prostaglandin reductase 2	PTGR2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
125	DNA polymerase beta	POLB	0.0007
1507	Cytochrome c	CYCS	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
1313	Lactoylglutathione lyase	GLO1	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
4954	Soluble cytochrome b558	Not Available	0.0005
4916	Cyanoglobin	glbN	0.0005
4947	Bacterial hemoglobin	vhb	0.0005
4915	Cytochrome c-550	psbV	0.0005
4959	Cytochrome c-550	psbV	0.0005
5216	Cytochrome c-550	psbV	0.0005
4925	Cytochrome c-type protein SHP	shp	0.0005
4934	Cytochrome c-551	nirM	0.0005
5218	Cytochrome c-551	nirM	0.0005
4936	Cytochrome c2 iso-2	Not Available	0.0005
4943	Cytochrome c6	petJ	0.0005
4975	Cytochrome c-556	RPA3973	0.0005
4905	Cytochrome c2	Not Available	0.0005
4939	Cytochrome c2	cycA	0.0005
4964	Cytochrome c2	cycA	0.0005
4979	Cytochrome c2	cycA	0.0005
6673	Cytochrome c2	cycA	0.0005
4998	Hemoglobin-like protein yjbI	yjbI	0.0005
4994	Hemoglobin-like protein HbO	glbO	0.0005
5000	HemO	hemO	0.0005
4984	Neuroglobin	NGB	0.0005
4909	CooA protein	cooA	0.0005
4904	Cytochrome c family protein	GSU1996	0.0005
4910	Cytoglobin	CYGB	0.0005
4961	Hemophore HasA	hasA	0.0005
4981	Iron-starvation protein PigA	pigA	0.0005
4935	Cytochrome c-554	cycA1	0.0005
4942	Diheme cytochrome c napB	napB	0.0005
4971	Nonaheme cytochrome c	hmcA	0.0005
644	Heme oxygenase 2	HMOX2	0.0005
4982	Heme oxygenase 2	pbsA2	0.0005
4907	Cytochrome c-L	moxG	0.0005
6865	Cytochrome c-L	moxG	0.0005
4989	Cytochrome c551 peroxidase	ccp	0.0005
5222	Cytochrome c551 peroxidase	ccpA	0.0005
4976	Apocytochrome f	petA	0.0005
6407	Apocytochrome f	petA	0.0005
4937	Cytochrome oxidase subunit II	rcoxA	0.0005
4764	Cytochrome P450 165C4	CYP165C4	0.0005
4931	Cytochrome P450 167A1	CYP167A1	0.0005
4999	Cytochrome P450 165B3	CYP165B3	0.0005
4960	Putative cytochrome P450-family protein	SCO7417	0.0005
4922	Cytochrome c, putative	SO_4144	0.0005
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0005
4903	Methyl-accepting chemotaxis protein	Tar4	0.0005
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0005
4993	Hydroxylamine oxidoreductase	hao1	0.0005
4972	P450cin	cinA	0.0005
4952	Catalase/peroxidase	katA	0.0005
3093	Catalase HPII	katE	0.0005
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
5818	Folate receptor alpha	FOLR1	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
4920	Peroxidase/catalase	katG	0.0004
2119	Cytochrome b5	CYB5A	0.0004
4990	PpcA	ppcA	0.0004
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0004
3375	Acidic cytochrome c3	Not Available	0.0004
4988	Sulfite oxidase, mitochondrial	SUOX	0.0004
2915	Sensor protein fixL	fixL	0.0004
4944	Sensor protein fixL	fixL	0.0004
3570	Cytochrome P450 152A1	cypC	0.0004
4385	Cytochrome c'	Not Available	0.0004
4967	Cytochrome c'	cycA	0.0004
5038	Cytochrome c'	Not Available	0.0004
5223	Cytochrome c'	cycP	0.0004
4037	Hypothetical protein	GPX1	0.0004
4297	Hypothetical protein	SP_1951	0.0004
4521	Hypothetical protein	BC_2969	0.0004
4540	Hypothetical protein	TM_1070	0.0004
4555	Hypothetical protein	MT1739	0.0004
4569	Hypothetical protein	mshD	0.0004
4578	Hypothetical protein	PA3270	0.0004
4747	Hypothetical protein	PA3967	0.0004
5177	Hypothetical protein	TM_0096	0.0004
5194	Hypothetical protein	PA1204	0.0004
5240	Hypothetical protein	Rv2991	0.0004
5370	Hypothetical protein	TM_1158	0.0004
5710	Hypothetical protein	Tb927.5.1360	0.0004
4813	Heme oxygenase	hmuO	0.0004
5769	Heme oxygenase	Not Available	0.0004
4992	Cytochrome c peroxidase	Not Available	0.0004
4289	Cytochrome P450	TT_P0059	0.0004
6262	Cytochrome P450	staP	0.0004
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0003
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0003
6501	Fatty acid-binding protein, liver	FABP1	0.0003
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0003
4608	Putative cytochrome P450	SCO1207	0.0003
4963	Putative cytochrome P450	SCO2884	0.0003
6254	Putative cytochrome P450	SCO6998	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00201 - Caffeine

Targets

Enzymes

Transporters

Predictions