DT-Web

DB00363 - Clozapine


Identification
Name Clozapine
Accession Number DB00363 (APRD00470)
Type small molecule
Description A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 326.823
Groups approved
Monoisotopic Weight 326.129824335
Pharmacology
Indication For use in patients with treatment-resistant schizophrenia.
Mechanism of action Clozapine's antipsychotic action is likely mediated through a combination of antogistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex. D2 antagonism relieves positive symptoms while 5-HT2A antagonism alleviates negative symptoms.
Absorption Rapid and almost complete
Protein binding 97% (bound to serum proteins)
Biotransformation Hepatic
Route of elimination Approximately 50% of the administered dose is excreted in the urine and 30% in the feces.
Toxicity Clozapine carries a black-box warning for agranulocytosis.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
ado-trastuzumab emtansine Avoid combination due to the increased potential for agranulocytosis.
Alprazolam Increased risk of toxicity
Bromazepam Bromazepam may increase the adverse effects of clozapine. Consider alternate therapy or a reduction in the bromazepam dose. Monitor for respiratory depression and hypotension if concomitant therapy is initiated.
Caffeine Caffeine increases the effect and toxicity of clozapine
Carbamazepine Carbamazepine may decrease the serum concentration of clozapine by increasing its metabolism. Concomitant therapy should also be avoided due to increased risk of bone marrow suppression. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of clozapine if carbamazepine is initiated, discontinued or dose changed.
Chlordiazepoxide Increased risk of toxicity
Cimetidine Cimetidine may increase the serum concentratin of clozapine. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of clozapine if cimetidine is initiated, discontinued or dose changed.
Cinolazepam Increased risk of toxicity
Ciprofloxacin Ciprofloxacin may increase clozapine serum levels
Citalopram The antidepressant increases the effect of clozapine
Clobazam Increased risk of toxicity
Clonazepam Increased risk of toxicity
Clorazepate Increased risk of toxicity
Diazepam Increased risk of toxicity
Dihydrocodeine CNS depressants may enhance the adverse effects and toxicity of other CNS depressants. It is recommended to monitor therapy.
Donepezil Possible antagonism of action
Erythromycin Erythromycin increases the effect of clozapine
Estazolam Increased risk of toxicity
Ethotoin Hydantoin decreases the effect of clozapine
Flunitrazepam Increased risk of toxicity
Fluoxetine The antidepressant increases the effect of clozapine
Flurazepam Increased risk of toxicity
Fluvoxamine The antidepressant increases the effect of clozapine
Fosphenytoin Hydantoin decreases the effect of clozapine
Galantamine Possible antagonism of action
Halazepam Increased risk of toxicity
Haloperidol Clozapine, a moderate CYP2D6 inhibitor, may increase the serum concentration of haloperidol by decreasing its metabolism. Additive CNS despresant and anticholinergic effects may also occur. Monitor for changes in the therapeutic and adverse effects of haloperidol if clozapine is initiated, discontinued or dose changed. Also monitor for increased CNS depressant and anticholinergic effects during concomitant therapy.
Josamycin Erythromycin increases the effect of clozapine
Ketazolam Increased risk of toxicity
Lamotrigine Lamotrigine increases the effect and toxicity of clozapine
Lorazepam Increased risk of toxicity
Mephenytoin Hydantoin decreases the effect of clozapine
Midazolam Increased risk of toxicity
Modafinil Modafinil increases the effect and toxicity of clozapine
Nitrazepam Increased risk of toxicity
Norfloxacin Ciprofloxacin may increase clozapine serum levels
Oxazepam Increased risk of toxicity
Paclitaxel Avoid combination due to the potential enhancement of agranulocytosis by clozapine.
Phenytoin Phenytoin may decrease the effect of clozapine.
Prazepam Increased risk of toxicity
Quazepam Increased risk of toxicity
Rifabutin Rifabutin decreases the effect of clozapine
Rifampin Rifampin decreases the effect of clozapine
Ritonavir Ritonavir increases the effect and toxicity of clozapine
Rivastigmine Possible antagonism of action
Sertraline The antidepressant increases the effect of clozapine
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Clozapine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Tamoxifen Clozapine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin Clozapine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Clozapine is initiated, discontinued, or dose changed.
Temazepam The benzodiazepine, Temazepam, may increase the adverse effects of Clozapine. Monitor for respiratory depression and hypotension if concomitant therapy is initiated.
Tetrabenazine May cause dopamine deficiency. Monitor for Tetrabenazine adverse effects. Similar pharmacologic properties thus combination therapy will worsen the severity of sedative, parkinsonian, and extrapyramidal adverse effects.
Thiabendazole The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Clozapine by decreasing Clozapine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Clozapine if Thiabendazole is initiated, discontinued or dose changed.
Tofacitinib Avoid combination due to the increased risk of clozapine induced agranulocytosis.
Tramadol Clozapine may decrease the effect of Tramadol by decreasing active metabolite production.
Triazolam Increased risk of toxicity
Trimethobenzamide Trimethobenzamide and Clozapine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine Triprolidine and Clozapine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Clozapine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Vilazodone Selective Serotonin Reuptake Inhibitors may decrease the metabolism of clozapine. If concurrent use of these agents is employed, monitor for increased toxic effects of clozapine if a selective serotonin reuptake inhibitor (SSRI) is initiated/dose increased, or decreased effects if a SSRI is discontinued/dose decreased.
Food Interactions
  • Take without regard to meals.
  • Avoid alcohol.
  • Limit caffeine intake (may reduce clozapine matabolism).

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Green AI, Salomon MS, Brenner MJ, Rawlins K: Treatment of schizophrenia and comorbid substance use disorder. Curr Drug Targets CNS Neurol Disord. 2002 Apr;1(2):129-39. - Pubmed
  • Weizman T, Pick CG, Backer MM, Rigai T, Bloch M, Schreiber S: The antinociceptive effect of amisulpride in mice is mediated through opioid mechanisms. Eur J Pharmacol. 2003 Oct 8;478(2-3):155-9. - Pubmed
  • Young RM, Lawford BR, Barnes M, Burton SC, Ritchie T, Ward WK, Noble EP: Prolactin levels in antipsychotic treatment of patients with schizophrenia carrying the DRD2*A1 allele. Br J Psychiatry. 2004 Aug;185:147-51. - Pubmed
  • Stonehouse AH, Jones FS: Bromocriptine and clozapine regulate dopamine 2 receptor gene expression in the mouse striatum. J Mol Neurosci. 2005;25(1):29-36. - Pubmed
  • Takano A, Suhara T, Kusumi I, Takahashi Y, Asai Y, Yasuno F, Ichimiya T, Inoue M, Sudo Y, Koyama T: Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jan;30(1):75-81. Epub 2005 Jul 22. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1569
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Goldstein JM: Quetiapine fumarate (Seroquel): a new atypical antipsychotic. Drugs Today (Barc). 1999 Mar;35(3):193-210. - Pubmed
  • McDonald LM, Moran PM, Vythelingum GN, Joseph MH, Stephenson JD, Gray JA: Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning. Psychopharmacology (Berl). 2003 Sep;169(3-4):321-31. Epub 2002 Aug 9. - Pubmed
  • Broderick PA, Hope O, Okonji C, Rahni DN, Zhou Y: Clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):157-71. - Pubmed
  • Heiser P, Schulte E, Hausmann C, Becker R, Remschmidt H, Krieg JC, Vedder H: Effects of clozapine and its metabolites on the 5-HT2 receptor system in cortical and hippocampal cells in vitro. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Mar;28(2):297-302. - Pubmed
  • Reist C, Mazzanti C, Vu R, Fujimoto K, Goldman D: Inter-relationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr. Mol Psychiatry. 2004 Sep;9(9):871-8. - Pubmed
  • Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed
DTHybrid score 1.1204
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.9345
D(3) dopamine receptor
Name D(3) dopamine receptor
Gene Name DRD3
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7274
D(4) dopamine receptor
Name D(4) dopamine receptor
Gene Name DRD4
Pharmacological action unknown
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Zhao AL, Zhao JP, Zhang YH, Xue ZM, Chen JD, Chen XG: Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine. Int J Neurosci. 2005 Nov;115(11):1539-47. - Pubmed
  • Nakane M, Cowart MD, Hsieh GC, Miller L, Uchic ME, Chang R, Terranova MA, Donnelly-Roberts DL, Namovic MT, Miller TR, Wetter JM, Marsh K, Stewart AO, Brioni JD, Moreland RB: 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49(1):112-21. Epub 2005 Apr 1. - Pubmed
  • Kuballa G, Nowak P, Labus L, Bortel A, Dabrowska J, Swoboda M, Kwiecinski A, Kostrzewa RM, Brus R: Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine. Pharmacol Rep. 2005 Mar-Apr;57(2):161-9. - Pubmed
  • Glatt SJ, Faraone SV, Tsuang MT: Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis. Biol Psychiatry. 2003 Sep 15;54(6):629-35. - Pubmed
  • Patel S, Chapman KL, Marston D, Hutson PH, Ragan CI: Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina. Neuropharmacology. 2003 Jun;44(8):1038-46. - Pubmed
DTHybrid score 0.6848
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action unknown
Actions antagonist
References
  • Hagino Y, Watanabe M: Effects of clozapine on the efflux of serotonin and dopamine in the rat brain: the role of 5-HT1A receptors. Can J Physiol Pharmacol. 2002 Dec;80(12):1158-66. - Pubmed
  • Chou YH, Halldin C, Farde L: Occupancy of 5-HT1A receptors by clozapine in the primate brain: a PET study. Psychopharmacology (Berl). 2003 Mar;166(3):234-40. Epub 2003 Feb 13. - Pubmed
  • Newman-Tancredi A, Rivet JM, Cussac D, Touzard M, Chaput C, Marini L, Millan MJ: Comparison of hippocampal G protein activation by 5-HT(1A) receptor agonists and the atypical antipsychotics clozapine and S16924. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):188-99. Epub 2003 Aug 16. - Pubmed
  • Zahorodna A, Bobula B, Grzegorzewska M, Tokarski K, Hess G: The influence of repeated administration of clozapine and haloperidol on the effects of the activation of 5-HT(1A), 5-HT(2) and 5-HT(4) receptors in rat frontal cortex. J Physiol Pharmacol. 2004 Jun;55(2):371-9. - Pubmed
  • Tomic M, Kundakovic M, Butorovic B, Janac B, Andric D, Roglic G, Ignjatovic D, Kostic-Rajacic S: Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4263-6. - Pubmed
DTHybrid score 0.9096
5-hydroxytryptamine 1B receptor
Name 5-hydroxytryptamine 1B receptor
Gene Name HTR1B
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7206
5-hydroxytryptamine 1D receptor
Name 5-hydroxytryptamine 1D receptor
Gene Name HTR1D
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7005
5-hydroxytryptamine 1E receptor
Name 5-hydroxytryptamine 1E receptor
Gene Name HTR1E
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.2934
5-hydroxytryptamine 2C receptor
Name 5-hydroxytryptamine 2C receptor
Gene Name HTR2C
Pharmacological action unknown
Actions antagonist
References
  • Sodhi MS, Airey DC, Lambert W, Burnet PW, Harrison PJ, Sanders-Bush E: A rapid new assay to detect RNA editing reveals antipsychotic-induced changes in serotonin-2C transcripts. Mol Pharmacol. 2005 Sep;68(3):711-9. Epub 2005 May 25. - Pubmed
  • Navailles S, De Deurwaerdere P, Spampinato U: Clozapine and haloperidol differentially alter the constitutive activity of central serotonin2C receptors in vivo. Biol Psychiatry. 2006 Mar 15;59(6):568-75. Epub 2005 Sep 22. - Pubmed
DTHybrid score 0.8031
5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.4167
5-hydroxytryptamine 6 receptor
Name 5-hydroxytryptamine 6 receptor
Gene Name HTR6
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.4059
5-hydroxytryptamine 7 receptor
Name 5-hydroxytryptamine 7 receptor
Gene Name HTR7
Pharmacological action unknown
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.5223
Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action no
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Roegge CS, Perraut C, Hao X, Levin ED: Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine. Pharmacol Biochem Behav. 2007 Apr;86(4):686-92. Epub 2007 Feb 22. - Pubmed
  • Leysen JE, Janssen PM, Megens AA, Schotte A: Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J Clin Psychiatry. 1994 May;55 Suppl:5-12. - Pubmed
DTHybrid score 1.0641
Histamine H4 receptor
Name Histamine H4 receptor
Gene Name HRH4
Pharmacological action no
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Sugata Y, Okano M, Fujiwara T, Matsumoto R, Hattori H, Yamamoto M, Nishibori M, Nishizaki K: Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. Epub 2007 Mar 7. - Pubmed
  • Smits RA, Lim HD, Stegink B, Bakker RA, de Esch IJ, Leurs R: Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives. J Med Chem. 2006 Jul 27;49(15):4512-6. - Pubmed
  • Adachi N, Liu K, Motoki A, Nishibori M, Arai T: Suppression of ischemia/reperfusion liver injury by histamine H4 receptor stimulation in rats. Eur J Pharmacol. 2006 Aug 21;544(1-3):181-7. Epub 2006 Jun 29. - Pubmed
DTHybrid score 0.1602
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0643
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7275
Alpha-2A adrenergic receptor
Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0392
Alpha-2B adrenergic receptor
Name Alpha-2B adrenergic receptor
Gene Name ADRA2B
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7714
Alpha-2C adrenergic receptor
Name Alpha-2C adrenergic receptor
Gene Name ADRA2C
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7738
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.1934
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0357
Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 1.0237
Muscarinic acetylcholine receptor M4
Name Muscarinic acetylcholine receptor M4
Gene Name CHRM4
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.8056
Muscarinic acetylcholine receptor M5
Name Muscarinic acetylcholine receptor M5
Gene Name CHRM5
Pharmacological action no
Actions antagonist
References
  • Nasrallah HA: Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry. 2008 Jan;13(1):27-35. Epub 2007 Sep 11. - Pubmed
DTHybrid score 0.7129
D1 dopamine receptor-interacting protein calcyon
Name D1 dopamine receptor-interacting protein calcyon
Gene Name CALY
Pharmacological action unknown
Actions unknown
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2315

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Brosen K: Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet. 1995;29 Suppl 1:20-5. - Pubmed
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Fang J, Coutts RT, McKenna KF, Baker GB: Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine. Naunyn Schmiedebergs Arch Pharmacol. 1998 Nov;358(5):592-9. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Carrillo JA, Benitez J: Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet. 2000 Aug;39(2):127-53. - Pubmed
DTHybrid score 1.1288
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.4156
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.9256
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.5453
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8268
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4925
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5987
Dimethylaniline monooxygenase [N-oxide-forming] 3
Name Dimethylaniline monooxygenase [N-oxide-forming] 3
Gene Name FMO3
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.2252
UDP-glucuronosyltransferase 1-4
Name UDP-glucuronosyltransferase 1-4
Gene Name UGT1A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.2755
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6086
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4783
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2525

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Boulton DW, DeVane CL, Liston HL, Markowitz JS: In vitro P-glycoprotein affinity for atypical and conventional antipsychotics. Life Sci. 2002 May 31;71(2):163-9. - Pubmed
DTHybrid score 0.9075

Predictions


Id Partner name Gene Name Score
4118 Cytochrome P450 3A5 CYP3A5 0.5437
163 D(1B) dopamine receptor DRD5 0.4899
436 5-hydroxytryptamine 2B receptor HTR2B 0.431
6107 Cytochrome P450 3A7 CYP3A7 0.4039
6030 Cytochrome P450 2B6 CYP2B6 0.403
789 Alpha-1D adrenergic receptor ADRA1D 0.3894
540 Sodium-dependent noradrenaline transporter SLC6A2 0.2924
824 Sodium-dependent serotonin transporter SLC6A4 0.271
6145 Solute carrier family 22 member 1 SLC22A1 0.2559
587 Serum albumin ALB 0.2303
1181 Alpha-1-acid glycoprotein 1 ORM1 0.2238
766 Beta-2 adrenergic receptor ADRB2 0.2017
3941 Amine oxidase [flavin-containing] A MAOA 0.1982
6144 Solute carrier family 22 member 2 SLC22A2 0.196
193 Beta-1 adrenergic receptor ADRB1 0.1917
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1899
20 Prostaglandin G/H synthase 1 PTGS1 0.1837
713 Sodium-dependent dopamine transporter SLC6A3 0.1833
3923 Cholinesterase BCHE 0.1632
511 5-hydroxytryptamine 1F receptor HTR1F 0.154
118 Organic cation/carnitine transporter 2 SLC22A5 0.1359
6106 Cytochrome P450 2C18 CYP2C18 0.1356
6147 Solute carrier family 22 member 3 SLC22A3 0.1329
124 Histamine H2 receptor HRH2 0.1324
465 Calmodulin CALM1 0.1312
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.1239
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.1221
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.1114
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1073
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1007
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1005
3811 Cytochrome P450 19A1 CYP19A1 0.0991
174 Sigma 1-type opioid receptor SIGMAR1 0.0951
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0927
862 Multidrug resistance-associated protein 1 ABCC1 0.0907
776 Bile salt export pump ABCB11 0.0882
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0862
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0839
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0836
131 Synaptic vesicular amine transporter SLC18A2 0.0835
1729 Solute carrier family 22 member 6 SLC22A6 0.0824
6859 Protein S100-A4 S100A4 0.0822
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0818
290 Prostaglandin G/H synthase 2 PTGS2 0.0796
3947 Xanthine dehydrogenase/oxidase XDH 0.0778
94 5-hydroxytryptamine 4 receptor HTR4 0.0769
833 Organic cation/carnitine transporter 1 SLC22A4 0.0761
1341 Histamine H3 receptor HRH3 0.0724
1517 Beta-3 adrenergic receptor ADRB3 0.072
136 Estrogen receptor ESR1 0.0674
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0671
3939 Amine oxidase [flavin-containing] B MAOB 0.0661
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0642
696 Kappa-type opioid receptor OPRK1 0.0606
260 Cytochrome P450 51 ERG11 0.0575
761 Cytochrome P450 51 ERG11 0.0575
3163 Cytochrome P450 51 cyp51 0.0575
4203 Histamine N-methyltransferase HNMT 0.057
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0562
847 Mu-type opioid receptor OPRM1 0.0557
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0555
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0536
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0536
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0534
468 Cytochrome P450 4A11 CYP4A11 0.0533
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0523
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0515
467 Delta-type opioid receptor OPRD1 0.0489
474 Acetylcholinesterase ACHE 0.0487
6142 Solute carrier family 22 member 8 SLC22A8 0.0485
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0484
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0477
871 Glucocorticoid receptor NR3C1 0.0468
6143 Solute carrier family 22 member 7 SLC22A7 0.0468
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.046
6102 Arylamine N-acetyltransferase 2 NAT2 0.046
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0451
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0451
817 DNA topoisomerase 2-alpha TOP2A 0.0447
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0424
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0424
6070 Nischarin NISCH 0.0421
1656 CYP2B protein CYP2B 0.042
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.041
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0408
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0407
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0407
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0399
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0396
844 Epidermal growth factor receptor EGFR 0.0392
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0385
2164 Multidrug resistance-associated protein 4 ABCC4 0.0374
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0372
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0369
731 HIV-1 protease HIV-1 protease 0.0364
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0362
6020 Aldehyde oxidase AOX1 0.0357
828 Phenylalanine-4-hydroxylase PAH 0.0352
3109 Phenylalanine-4-hydroxylase phhA 0.0352
6014 Cytochrome P450 2A13 CYP2A13 0.0351
6031 Cytochrome P450 3A43 CYP3A43 0.0345
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0342
856 Vitamin D3 receptor VDR 0.0338
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0336
2129 Sucrase-isomaltase, intestinal SI 0.0331
6432 Transporter snf 0.033
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0328
6182 Cytochrome P450 2J2 CYP2J2 0.0326
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0326
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0317
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0312
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.031
380 Cytochrome P450 17A1 CYP17A1 0.0309
1192 Sulfotransferase 1A1 SULT1A1 0.0307
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0305
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0305
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0305
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0301
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0298
6148 Multidrug resistance-associated protein 7 ABCC10 0.0297
4604 Liver carboxylesterase 1 CES1 0.0293
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0292
869 Estrogen receptor beta ESR2 0.0292
1757 Myeloperoxidase MPO 0.0287
3810 Catechol O-methyltransferase COMT 0.0287
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0283
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0282
777 Tumor necrosis factor TNF 0.0281
146 Androgen receptor AR 0.028
1636 Trace amine-associated receptor 1 TAAR1 0.0279
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0279
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0277
504 Mast/stem cell growth factor receptor KIT 0.0272
571 Melatonin receptor type 1A MTNR1A 0.0272
362 Melatonin receptor type 1B MTNR1B 0.0272
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0271
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.027
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0269
1024 Solute carrier family 22 member 11 SLC22A11 0.0269
122 P2Y purinoceptor 12 P2RY12 0.0267
16 Adenosine A1 receptor ADORA1 0.0266
36 Insulin receptor INSR 0.0258
4120 NADPH--cytochrome P450 reductase POR 0.0256
183 Vascular endothelial growth factor A VEGFA 0.0255
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0255
6220 Aryl hydrocarbon receptor AHR 0.0254
891 Dihydropteroate synthase folP 0.0251
5359 Dihydropteroate synthase folP 0.0251
7175 Dihydropteroate synthase sulI 0.0251
1178 Adenosine A2a receptor ADORA2A 0.0248
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0248
5251 Carbonyl reductase [NADPH] 1 CBR1 0.024
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0237
3426 Glutamine synthetase glnA 0.0235
3987 Glutamine synthetase GLUL 0.0235
228 Beta platelet-derived growth factor receptor PDGFRB 0.0234
921 Glutamate receptor 2 GRIA2 0.023
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0229
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0229
6151 Monocarboxylate transporter 10 SLC16A10 0.0225
6141 Sodium/bile acid cotransporter SLC10A1 0.0223
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0218
477 DNA topoisomerase 4 subunit A parC 0.0217
886 DNA topoisomerase 4 subunit A parC 0.0217
6226 DNA topoisomerase 4 subunit A parC 0.0217
1010 Cytochrome P450 51A1 CYP51A1 0.0215
404 DNA gyrase subunit A gyrA 0.0214
6224 DNA gyrase subunit A gyrA 0.0214
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0213
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0209
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0209
6137 Multidrug resistance-associated protein 6 ABCC6 0.0209
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0208
373 Transthyretin TTR 0.0206
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0202
614 Progesterone receptor PGR 0.0199
70 Type-1 angiotensin II receptor AGTR1 0.0199
6138 Multidrug resistance protein 3 ABCB4 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
6136 Multidrug resistance-associated protein 5 ABCC5 0.0197
5787 Angiopoietin-1 receptor TEK 0.0195
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0195
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0195
4228 Keratin, type II cytoskeletal 7 KRT7 0.0194
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0192
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.019
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.019
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0188
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0188
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0187
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0187
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0187
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0187
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0187
1618 High affinity nerve growth factor receptor NTRK1 0.0186
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0186
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0184
1063 Signal transducer and activator of transcription 5B STAT5B 0.0184
3808 Dihydropteroate synthase 2 folP2 0.0183
3601 Dihydropteroate synthase 1 folP1 0.0183
3807 Dihydropteroate synthase 1 folP1 0.0183
482 Glycine receptor subunit alpha-1 GLRA1 0.0182
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0182
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0181
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0181
723 Cytosolic phospholipase A2 PLA2G4A 0.0181
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0181
1275 Estrogen sulfotransferase SULT1E1 0.018
6100 BDNF/NT-3 growth factors receptor NTRK2 0.018
613 Atrial natriuretic peptide receptor A NPR1 0.0179
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0178
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0178
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0178
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0178
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0177
811 Translocator protein TSPO 0.0177
29 Tubulin beta-1 chain TUBB1 0.0175
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0173
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0172
1360 Sphingomyelin phosphodiesterase SMPD1 0.0172
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0172
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0171
153 Dopamine beta-hydroxylase DBH 0.017
936 Ephrin type-A receptor 2 EPHA2 0.0169
516 Neurotensin receptor type 2 NTSR2 0.0168
756 Sex hormone-binding globulin SHBG 0.0164
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0164
4122 Histone deacetylase 2 HDAC2 0.0162
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0157
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0157
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0152
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0152
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0152
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.015
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
904 Glutathione S-transferase P GSTP1 0.015
161 Tubulin beta chain TUBB 0.015
312 Tubulin beta chain TUB2 0.015
923 Glutamate receptor 3 GRIA3 0.0149
484 Tyrosine-protein kinase ABL2 ABL2 0.0148
2449 Tubulin alpha-3 chain TUBA1A 0.0148
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0148
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0148
1629 Transcription factor AP-1 JUN 0.0147
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0146
3932 Glutathione S-transferase A2 GSTA2 0.0145
2499 Tubulin beta-2C chain TUBB2C 0.0144
365 Dihydrofolate reductase DHFR 0.0143
2381 Dihydrofolate reductase DFR1 0.0143
2833 Dihydrofolate reductase Not Available 0.0143
2931 Dihydrofolate reductase folA 0.0143
3544 Dihydrofolate reductase folA 0.0143
3682 Dihydrofolate reductase folA 0.0143
6642 Dihydrofolate reductase folA 0.0143
6756 Dihydrofolate reductase dfrA 0.0143
273 Apoptosis regulator Bcl-2 BCL2 0.014
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.014
3809 Estrogen-related receptor gamma ESRRG 0.0138
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0138
295 Carbonic anhydrase 1 CA1 0.0138
537 ATP synthase delta chain, mitochondrial ATP5D 0.0138
407 Vascular endothelial growth factor receptor 2 KDR 0.0137
233 Potassium channel subfamily K member 2 KCNK2 0.0137
705 Glutamate receptor 1 GRIA1 0.0137
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0136
232 Corticosteroid-binding globulin SERPINA6 0.0135
737 Mineralocorticoid receptor NR3C2 0.0134
427 Substance-P receptor TACR1 0.0134
814 Ryanodine receptor 1 RYR1 0.0134
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0132
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0132
4116 Dihydropteroate synthetase Not Available 0.0131
738 Monocarboxylate transporter 1 SLC16A1 0.013
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
26 Vascular endothelial growth factor receptor 3 FLT4 0.0128
818 50S ribosomal protein L10 rplJ 0.0128
952 Dipeptidyl peptidase 4 DPP4 0.0128
4237 50S ribosomal protein L22 rplV 0.0127
592 Carbonic anhydrase 4 CA4 0.0125
251 Alcohol dehydrogenase 1A ADH1A 0.0125
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0124
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0123
32 Vascular endothelial growth factor receptor 1 FLT1 0.0122
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0122
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0122
68 Cannabinoid receptor 1 CNR1 0.0122
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
444 Alcohol dehydrogenase 1B ADH1B 0.0121
518 Peroxidase/catalase T katG 0.012
275 Arachidonate 5-lipoxygenase ALOX5 0.012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0119
1852 Microtubule-associated protein 2 MAP2 0.0118
84 Nuclear receptor 0B1 NR0B1 0.0118
6146 High affinity copper uptake protein 1 SLC31A1 0.0118
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0117
4238 50S ribosomal protein L4 rplD 0.0117
5578 50S ribosomal protein L4 rplD 0.0117
6173 50S ribosomal protein L4 rplD 0.0117
6219 50S ribosomal protein L4 rplD 0.0117
48 Pyridoxal kinase PDXK 0.0116
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
6085 Fatty acid-binding protein, intestinal FABP2 0.0113
2230 Catalase CAT 0.0111
3249 Catalase katA 0.0111
3625 Catalase katA 0.0111
4539 Catalase katA 0.0111
4941 Catalase katB 0.0111
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0111
606 Cytochrome P450 27, mitochondrial CYP27A1 0.011
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.011
1714 Mitogen-activated protein kinase 3 MAPK3 0.0109
2112 Toll-like receptor 9 TLR9 0.0108
267 Plasminogen activator inhibitor 1 SERPINE1 0.0107
6766 O-GlcNAcase BT_4395 BT_4395 0.0105
823 Fibroblast growth factor receptor 2 FGFR2 0.0105
1039 Histone deacetylase 9 HDAC9 0.0103
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0102
1050 Bile salt sulfotransferase SULT2A1 0.0101
5923 Microtubule-associated protein tau MAPT 0.0101
5924 Microtubule-associated protein 4 MAP4 0.0101
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0098
6221 Steroid hormone receptor ERR1 ESRRA 0.0098
106 Cannabinoid receptor 2 CNR2 0.0098
517 Alcohol dehydrogenase 1C ADH1C 0.0098
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0097
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0097
4311 tRNA TRDMT1 0.0097
4325 tRNA trmD 0.0097
4328 tRNA trmD 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4148 Serine/threonine-protein kinase mTOR MTOR 0.0097
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0097
563 Thyroid peroxidase TPO 0.0097
3937 Fatty-acid amide hydrolase FAAH 0.0097
49 Endothelin B receptor EDNRB 0.0096
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0095
5934 Cytochrome P450 26A1 CYP26A1 0.0094
6126 Carbonic anhydrase 7 CA7 0.0094
469 Annexin A1 ANXA1 0.0094
1569 G1/S-specific cyclin-D1 CCND1 0.0094
88 Retinoic acid receptor RXR-beta RXRB 0.0093
357 Carbonic anhydrase 2 CA2 0.0093
7 Nitric oxide synthase, inducible NOS2 0.0091
24 Thymidylate synthase TMP1 0.0091
359 Thymidylate synthase TYMS 0.0091
2626 Thymidylate synthase thyA 0.0091
2729 Thymidylate synthase thyA 0.0091
5352 Thymidylate synthase THYA 0.0091
578 Endothelin-1 receptor EDNRA 0.009
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0089
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0089
2236 Casein kinase II subunit alpha CSNK2A1 0.0089
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0089
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0089
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0088
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0088
268 Adenosine A2b receptor ADORA2B 0.0088
3830 Calreticulin CALR 0.0088
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
908 Glutathione S-transferase theta-1 GSTT1 0.0086
239 Coagulation factor X F10 0.0086
6174 50S ribosomal protein L32 rpmF 0.0086
3957 Adenosine deaminase ADA 0.0085
4192 DNA topoisomerase 2-beta TOP2B 0.0084
820 Glycine receptor subunit alpha-2 GLRA2 0.0083
1176 Mitogen-activated protein kinase 1 MAPK1 0.0083
4103 Proteasome subunit beta type 2 PSMB2 0.0083
4102 Proteasome subunit beta type 5 PSMB5 0.0083
4101 Proteasome subunit beta type 1 PSMB1 0.0083
6034 Hydroxyindole O-methyltransferase ASMT 0.0081
6035 Nuclear receptor ROR-beta RORB 0.0081
6036 Eosinophil peroxidase EPX 0.0081
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0081
284 DNA-directed RNA polymerase beta chain rpoB 0.008
5773 DNA-directed RNA polymerase beta chain rpoB 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
976 Platelet glycoprotein IX GP9 0.008
1374 Natriuretic peptides B NPPB 0.008
1827 Gap junction alpha-1 protein GJA1 0.008
1908 Vascular cell adhesion protein 1 VCAM1 0.0079
634 Squalene monooxygenase SQLE 0.0079
7196 Squalene monooxygenase ERG1 0.0079
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0079
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
780 Retinoic acid receptor RXR-gamma RXRG 0.0079
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0079
173 Toll-like receptor 7 TLR7 0.0079
2183 Fatty acid-binding protein, adipocyte FABP4 0.0077
6043 Putative G-protein coupled receptor 44 GPR44 0.0077
33 Cystine/glutamate transporter SLC7A11 0.0076
244 Angiotensin-converting enzyme ACE 0.0076
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0076
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0076
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0076
319 Opioid receptor, sigma 1 OPRS1 0.0075
3917 Methylenetetrahydrofolate reductase MTHFR 0.0075
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0074
1541 Metalloproteinase mmp20 0.0074
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0074
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0074
2539 Tubulin alpha-1 chain TUBA4A 0.0073
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
5300 Antigen peptide transporter 1 TAP1 0.0071
765 Indoleamine 2,3-dioxygenase IDO1 0.0071
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0071
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.007
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.007
581 Cytochrome P450 2R1 CYP2R1 0.007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0069
162 Retinoic acid receptor gamma-1 RARG 0.0068
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
54 Prothrombin F2 0.0067
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0067
6163 Copper-transporting ATPase 2 ATP7B 0.0066
6165 Copper-transporting ATPase 1 ATP7A 0.0066
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0064
1820 Beta-nerve growth factor NGF 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1648 Elastin ELN 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1353 DNA topoisomerase 1 TOP1 0.0063
3552 DNA topoisomerase 1 topA 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
6044 Serum paraoxonase/lactonase 3 PON3 0.0062
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0061
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0061
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0061
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0061
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0061
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0061
6097 Protein S100-A2 S100A2 0.006
896 Glutathione S-transferase Mu 1 GSTM1 0.006
1810 Protein S100-A1 S100A1 0.006
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.006
2298 Cytochrome P450-cam camC 0.006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
322 Vasopressin V2 receptor AVPR2 0.0058
5880 Thrombopoietin receptor MPL 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0058
3856 Fibroblast growth factor receptor 3 FGFR3 0.0057
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
165 FL cytokine receptor FLT3 0.0057
400 Coagulation factor IX F9 0.0057
5461 Coagulation factor IX F9 0.0057
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0056
1992 Vitamin D-binding protein GC 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0055
6506 Stathmin-4 STMN4 0.0055
461 Glycine receptor subunit alpha-3 GLRA3 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
65 Matrix metalloproteinase-9 Not Available 0.0054
992 Protein tyrosine kinase 2 beta PTK2B 0.0054
569 Retinal dehydrogenase 2 ALDH1A2 0.0054
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0054
4217 Telomerase reverse transcriptase TERT 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0052
604 Vitamin K-dependent protein Z PROZ 0.0052
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
712 Tubulin alpha chain TUB1 0.0052
3090 Chitosanase csn 0.0052
1048 Protein S100-A13 S100A13 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
2226 Protein S100-A12 S100A12 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
694 Matrix protein 2 M 0.0051
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0051
611 Retinal dehydrogenase 1 ALDH1A1 0.0051
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.005
2981 Phospholipase A2, membrane associated PLA2G2A 0.005
3404 Exotoxin A eta 0.0049
2132 Protein S100-B S100B 0.0049
719 Retinoic acid receptor responder protein 1 RARRES1 0.0049
770 Retinoic acid-induced protein 3 GPRC5A 0.0049
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0048
422 Vitamin K-dependent protein C PROC 0.0048
1245 Vitamin K-dependent protein S PROS1 0.0048
2616 Ganglioside GM2 activator GM2A 0.0047
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0047
683 Potassium transporter GK0582 0.0047
1253 Interferon gamma IFNG 0.0046
751 Potassium channel subfamily K member 6 KCNK6 0.0046
527 Prostacyclin receptor PTGIR 0.0045
3086 Plasmepsin-2 Not Available 0.0045
6149 Solute carrier family 22 member 10 SLC22A10 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
291 Nitric-oxide synthase, endothelial NOS3 0.0044
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
130 Prostacyclin synthase PTGIS 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
172 Potassium channel subfamily K member 1 KCNK1 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1630 Integrin beta-2 ITGB2 0.0042
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0042
2320 Thymidine kinase, cytosolic TK1 0.0042
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
229 Retinoic acid receptor beta RARB 0.0041
730 Retinoic acid receptor alpha RARA 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
3913 Glutamic acid decarboxylase GAD65 0.004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.004
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0039
4225 Uridine phosphorylase 1 UPP1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
798 Osteocalcin BGLAP 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0038
6824 Tyrosine-protein kinase Lyn LYN 0.0038
85 Growth hormone receptor GHR 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
2207 Rhodopsin RHO 0.0036
4773 Deoxycytidine kinase DCK 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
6131 Carbonic anhydrase 14 CA14 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
369 Coagulation factor VII F7 0.0035
1262 Corticotropin-lipotropin POMC 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0035
1268 Neuropeptide S receptor NPSR1 0.0035
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
758 Thyroid hormone receptor alpha THRA 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
735 Alanine aminotransferase 1 GPT 0.0033
3904 Alanine aminotransferase 2 GPT2 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0033
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0032
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0032
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0032
572 Integrin alpha-L ITGAL 0.0032
6168 Solute carrier family 22 member 16 SLC22A16 0.0032
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0032
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6073 Potassium channel subfamily K member 9 KCNK9 0.0031
6072 Potassium channel subfamily K member 3 KCNK3 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
1864 RET proto-oncogene RET 0.0029
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0029
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0029
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0029
6048 Troponin C, skeletal muscle TNNC2 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0029
6459 Glycodelin PAEP 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
5798 Mitogen-activated protein kinase 11 MAPK11 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
2408 Tyrosine-protein kinase SYK SYK 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
2216 Fibroblast growth factor receptor 4 FGFR4 0.0026
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
358 Cystathionine beta-synthase CBS 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
489 Monocarboxylate transporter 2 SLC16A7 0.0025
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0025
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0025
3007 Carbonic anhydrase 12 CA12 0.0025
4205 Carbonic anhydrase 9 CA9 0.0025
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
6218 Pannexin-1 PANX1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
822 Aldose reductase AKR1B1 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
76 Nitric-oxide synthase, brain NOS1 0.0022
707 72 kDa type IV collagenase MMP2 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3221 Cytochrome c4 cc4 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.002
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.002
293 Gamma-glutamyl hydrolase GGH 0.002
1970 Protein kinase C alpha type PRKCA 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
1650 Heme carrier protein 1 SLC46A1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
1792 Tissue-type plasminogen activator PLAT 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
1243 Cathepsin D CTSD 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
3238 Multidrug resistance protein mexA mexA 0.0016
3709 Glycerol uptake facilitator protein glpF 0.0016
3116 Bacterioferritin bfr 0.0016
4906 Bacterioferritin bfr 0.0016
4965 Bacterioferritin bfr 0.0016
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0016
3173 Enolase eno 0.0016
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0016
3393 TGF-beta receptor type-2 TGFBR2 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6755 Poliovirus receptor PVR 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0015
6677 Myelin P2 protein PMP2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2852 DNA mismatch repair protein mutL mutL 0.0014
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
3191 Histidinol dehydrogenase hisD 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
6042 Prostaglandin reductase 2 PTGR2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
4692 A/G-specific adenine glycosylase mutY 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2802 Endoglucanase G celCCG 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4386 Hemoglobin-like protein HbN glbN 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
1507 Cytochrome c CYCS 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
4954 Soluble cytochrome b558 Not Available 0.0005
4916 Cyanoglobin glbN 0.0005
4947 Bacterial hemoglobin vhb 0.0005
4915 Cytochrome c-550 psbV 0.0005
4959 Cytochrome c-550 psbV 0.0005
5216 Cytochrome c-550 psbV 0.0005
4925 Cytochrome c-type protein SHP shp 0.0005
4934 Cytochrome c-551 nirM 0.0005
5218 Cytochrome c-551 nirM 0.0005
4936 Cytochrome c2 iso-2 Not Available 0.0005
4943 Cytochrome c6 petJ 0.0005
4975 Cytochrome c-556 RPA3973 0.0005
4905 Cytochrome c2 Not Available 0.0005
4939 Cytochrome c2 cycA 0.0005
4964 Cytochrome c2 cycA 0.0005
4979 Cytochrome c2 cycA 0.0005
6673 Cytochrome c2 cycA 0.0005
4998 Hemoglobin-like protein yjbI yjbI 0.0005
4994 Hemoglobin-like protein HbO glbO 0.0005
5000 HemO hemO 0.0005
4984 Neuroglobin NGB 0.0005
4909 CooA protein cooA 0.0005
4904 Cytochrome c family protein GSU1996 0.0005
4910 Cytoglobin CYGB 0.0005
4961 Hemophore HasA hasA 0.0005
4981 Iron-starvation protein PigA pigA 0.0005
4935 Cytochrome c-554 cycA1 0.0005
4942 Diheme cytochrome c napB napB 0.0005
4971 Nonaheme cytochrome c hmcA 0.0005
644 Heme oxygenase 2 HMOX2 0.0005
4982 Heme oxygenase 2 pbsA2 0.0005
4907 Cytochrome c-L moxG 0.0005
6865 Cytochrome c-L moxG 0.0005
4989 Cytochrome c551 peroxidase ccp 0.0005
5222 Cytochrome c551 peroxidase ccpA 0.0005
4976 Apocytochrome f petA 0.0005
6407 Apocytochrome f petA 0.0005
4937 Cytochrome oxidase subunit II rcoxA 0.0005
4764 Cytochrome P450 165C4 CYP165C4 0.0005
4931 Cytochrome P450 167A1 CYP167A1 0.0005
4999 Cytochrome P450 165B3 CYP165B3 0.0005
4960 Putative cytochrome P450-family protein SCO7417 0.0005
4922 Cytochrome c, putative SO_4144 0.0005
4926 Heme-based aerotactic transducer hemAT hemAT 0.0005
4903 Methyl-accepting chemotaxis protein Tar4 0.0005
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0005
4993 Hydroxylamine oxidoreductase hao1 0.0005
4972 P450cin cinA 0.0005
4952 Catalase/peroxidase katA 0.0005
3093 Catalase HPII katE 0.0005
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
5818 Folate receptor alpha FOLR1 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
693 Hemoglobin subunit beta HBB 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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