DT-Web: DB00252

Identification

Name

Phenytoin

Accession Number

DB00252 (APRD00241)

Type

small molecule

Description

An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Anticonvulsants

Molecular Weight

252.268

Groups

approved

Monoisotopic Weight

252.089877638

Pharmacology

Indication

For the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery.

Mechanism of action

Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas.

Absorption

Bioavailability 70-100% oral, 24.4% for rectal and intravenous administration. Rapid rate of absorption with peak blood concentration expected in 1½ to 3 hours.

Protein binding

Highly protein bound, 90%

Biotransformation

Primarily hepatic. The majority of the dose (up to 90%) is metabolized to 5-(4'-hydroxyphenyl)-5-phenylhydantoin (p-HPPH). This metabolite undergoes further glucuronidation and is excreted into the urine. CYP2C19 and CYP2C9 catalyze the aforementioned reaction.

Route of elimination

Most of the drug is excreted in the bile as inactive metabolites which are then reabsorbed from the intestinal tract and excreted in the urine. Urinary excretion of phenytoin and its metabolites occurs partly with glomerular filtration but, more importantly, by tubular secretion.

Toxicity

Oral, mouse: LD₅₀ = 150 mg/kg; Oral, rat: LD₅₀ = 1635 mg/kg. Symptoms of overdose include coma, difficulty in pronouncing words correctly, involuntary eye movement, lack of muscle coordination, low blood pressure, nausea, sluggishness, slurred speech, tremors, and vomiting.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Abiraterone	Strong CYP3A4 inducers may decrease levels of abiraterone. Monitor concomitant therapy closely.
Acenocoumarol	Increased hydantoin levels and risk of bleeding
ado-trastuzumab emtansine	Avoid combination with phenytoin and other strong CYP3A4 inducers due to the likely increase in metabolism of ado-trastuzumab emtansine to its active component, DM1.
Alprazolam	Phenytoin may increase the metabolism of alprazolam via CYP3A4.
Aminophylline	Decreased effect of both products
Amiodarone	Amiodarone may increase the therapeutic and adverse effects of phenytoin.
Anisindione	Increased hydantoin levels and risk of bleeding
Aprepitant	The CYP3A4 inducer, phenytoin, may decrease the effect of aprepitant.
Asenapine	Phenytoin is a CYP1A2 inducer and may increase metabolism of asenapine.
Atracurium	Phenytoin decreases the effect of the muscle relaxant
Axitinib	Avoid combination with phenytoin and other strong, moderate, or weak CYP3A4 inducers due to the likely decreased levels of axitinib.
Betamethasone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, betamethasone.
Bleomycin	The antineoplasic agent decreases the effect of hydantoin
Boceprevir	Strong CYP3A4 inducers will decrease levels of boceprevir. Concomitant therapy is contraindicated.
Cabazitaxel	Concomitant therapy with a strong CYP3A inducer may decrease concentrations of cabazitaxel. Avoid concomitant therapy.
Canagliflozin	Nonselective inducers of UGT enzymes may decrease levels of canagliflozin, thus decreasing efficacy. Consider increase the dose to 300 mg once daily.
Capecitabine	Capecitabine increases the effect of hydantoin
Carboplatin	The antineoplasic agent decreases the effect of hydantoin
Carmustine	The antineoplasic agent decreases the effect of hydantoin
Chloramphenicol	Increases phenytoin, modifies chloramphenicol
Chlordiazepoxide	Phenytoin may increase the metabolism of chlordiazepoxide via CYP3A4.
Chlorotrianisene	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, chlorotrianisene.
Chlorpheniramine	The antihistamine increases the effect of hydantoin
Cimetidine	Cimetidine may increase the therapeutic effect of phenytoin.
Ciprofloxacin	Ciprofloxacin may decrease the therapeutic effect of phenytoin.
Cisplatin	The antineoplasic agent decreases the effect of hydantoin
Clarithromycin	Clarithromycin may increase the therapeutic and adverse effects of phenytoin.
Clomifene	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, clomifene.
Clorazepate	Phenytoin may increase the metabolism of clorazepate via CYP3A4.
Clozapine	Phenytoin may decrease the effect of clozapine.
Colesevelam	Colesevelam may decrease the serum concentration of Phenytoin. Phenytoin should be administered at least 4 hours prior to colesevelam.
Conjugated Estrogens	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, conjugated estrogens.
Cortisone acetate	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, cortisone acetate.
Cyclosporine	The hydantoin decreases the effect of cyclosporine
Dabrafenib	Strong CYP3A4 inducers may decrease levels of dabrafenib. Consider alternate therapy.
Dasatinib	Phenytoin may decrease the serum level and efficacy of dasatinib.
Delavirdine	The anticonvulsant, phenytoin, decreases the effect of delavirdine.
Dexamethasone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, dexamethasone.
Diazepam	Phenytoin may increase the metabolism of diazepam via CYP3A4.
Diazoxide	Diazoxide decreases the efficacy of phenytoin.
Dicumarol	Increased hydantoin levels and risk of bleeding
Diethylstilbestrol	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, diethylstilbestrol.
Disopyramide	The hydantoin decreases the effect of disopyramide
Disulfiram	Disulfiram may increase the therapeutic and adverse effects of phenytoin.
Dopamine	Risk of severe hypotension
Doxacurium chloride	Phenytoin decreases the effect of the muscle relaxant
Doxycycline	The anticonvulsant, phenytoin, may decrease the effect of doxycycline.
Dyphylline	Decreased effect of both products
Estradiol	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, estradiol.
Estradiol valerate/Dienogest	Affects CYP3A4 metabolism, decreases or effects levels of Estradiol valerate/Dienogest.
Estriol	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, estriol.
Estrone	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, estrone.
Estropipate	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, estropipate.
Ethinyl Estradiol	This product may cause a slight decrease of contraceptive effect
Etravirine	Etravirine, when used concomitantly with phenytoin, may experience a decrease in serum concentration. It is recommended to avoid concurrent therapy.
Ezogabine	Ezogabine increases the clearance of phenytoin (30%). The mechanism of this interaction is unknown.
Felbamate	Increased phenytoin levels and decreased felbamate levels
Felodipine	The hydantoin decreases the effect of felodipine
Fluconazole	Fluconazole may increase the therapeutic and adverse effects of phenytoin.
Fludrocortisone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, fludrocortisone.
Fluorouracil	Fluorouracil increases the effect of hydantoin
Fluoxetine	Fluoxetine increases the effect of phenytoin
Flurazepam	Phenytoin may increase the metabolism of flurazepam via CYP3A4.
Fluvoxamine	Fluvoxamine may increase the therapeutic effect of phenytoin.
Folic Acid	Folic acid may decrease the levels of phenytoin.
Furosemide	The hydantoin decreases the effect of furosemide
Gabapentin	Gabapentin may increase the therapeutic and adverse effects of phenytoin.
Gefitinib	The CYP3A4 inducer, phenytoin, may decrease the serum concentration and therapeutic effects of gefitinib.
Hydrocortisone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, hydrocortisone.
Imatinib	The hydantoin decreases the levels of imatinib
Irinotecan	The hydantoin decreases the effect of irinotecan
Isoniazid	Isoniazid increases the effect of phenytoin in 20% of patients
Itraconazole	Phenytoin decreases the effect of itraconazole
Ivacaftor	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Lamotrigine	Phenytoin may reduce levels of lamotrigine
Levodopa	The hydantoin decreases the effect of levodopa
Levonorgestrel	Phenytoin decreases the contraceptive effect
Lopinavir	Levels of both drugs are affected
Mebendazole	The hydantoin decreases the efficiency of mebendazole
Medroxyprogesterone	The enzyme inducer, phenytoin, may decrease the effect of medroxyprogesterone.
Megestrol	The enzyme inducer, phenytoin, may decrease the effect of megestrol.
Mestranol	This product may cause a slight decrease of contraceptive effect
Methadone	The hydantoin decreases the effect of methadone
Methotrexate	The antineoplasic agent decreases the effect of hydantoin
Methoxsalen	The hydantoin decreases the effect of psoralene
Methylprednisolone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, methylprednisolone.
Metocurine	Phenytoin decreases the effect of the muscle relaxant
Metyrapone	The combination renders the test invalid
Mexiletine	The hydantoin decreases the effect of mexiletine
Midazolam	Phenytoin may increase the metabolism of midazolam via CYP3A4.
Mirtazapine	The hydantoins may reduce mirtazapine plasma concentrations and pharmacological effects
Mivacurium	Phenytoin decreases the effect of the muscle relaxant
Nisoldipine	Phenytoin decreases the efficiency of nisoldipine
Norethindrone	This product may cause a slight decrease of contraceptive effect
Omeprazole	Omeprazole increases the effect of hydantoin
Oxcarbazepine	Oxcarbazepine increases the effect of hydantoin
Oxtriphylline	Decreased effect of both products
Oxyphenbutazone	The NSAID, oxphenbutazone, may increase the therapeutic and adverse effects of phenytoin.
Pancuronium	Phenytoin decreases the effect of the muscle relaxant
Paramethasone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, paramethasone.
Perampanel	Avoid combination with phenytoin or other strong CYP3A4 inducers due to the likely decrease of perampanel concentration. If the combination must be used, an increase in perampanel dose is necessary.
Phenylbutazone	The NSAID, phenylbutazone, may increase the therapeutic and adverse effects of phenytoin.
Ponatinib	Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Ponatinib	Strong CYP3A4 inducers may decrease levels of ponatinib. Monitor concomitant therapy closely.
Posaconazole	Modifications of drug levels for both agents
Praziquantel	Markedly lower praziquantel levels
Prednisolone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, prednisolone.
Prednisone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, prednisone.
Quetiapine	Phenytoin decreases the effect of quetiapine
Quinestrol	The enzyme inducer, phenytoin, decreases the effect of the hormone agent, quinestrol.
Quinidine	The anticonvulsant, phenytoin, decreases the effect of quinidine.
Regorafenib	Strong CYP3A4 inducers may decrease levels of regorafenib.
Rifampin	Rifampin may decrease the therapeutic and adverse effects of phenytoin.
Rilpivirine	Strong inducers of CYP3A4 decrease the exposure of rilpivirine thus decreasing efficacy.
Rufinamide	Increases clearance of rufinamide thus decreasing plasma concentration of rufinamide.
Sertraline	Sertraline increases the effect of hydantoin
Sirolimus	The hydantoin decreases sirolimus levels
Sucralfate	Sucralfate decreases the effect of hydantoin
Sulfadiazine	The sulfonamide increases the effect of hydantoin
Sulfamethizole	The sulfonamide increases the effect of hydantoin
Sunitinib	Possible decrease in sunitinib levels
Tacrolimus	Phenytoin may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Phenytoin therapy is initiated, discontinued or altered.
Telithromycin	Phenytoin may decrease the plasma concentration of Telithromycin by increasing its metabolism. Consider alternate therapy.
Temsirolimus	Phenytoin may increase the metabolism of Temsirolimus decreasing its efficacy. Concomitant therapy should be avoided.
Theophylline	Decreased effect of both products
Thiotepa	Possible increase in thiotepa levels
Ticlopidine	Ticlopidine may decrease the metabolism and clearance of phenytoin. Consider alternate therapy or monitor for adverse/toxic effects of phenytoin if ticlopidine is initiated, discontinued or dose changed.
Tipranavir	Phenytoin decreases the concentration of Tipranavir. Monitor for decreased Tipranavir efficacy.
Tobramycin	Increased risk of nephrotoxicity
Tofacitinib	Avoid combination with phenytoin and other strong CYP3A4 inducers due to the potential decrease in tofacitinib serum levels.
Tolbutamide	Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Phenytoin. Consider alternate therapy or monitor for changes in Phenytoin therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Tolvaptan	Phenytoin is a CYP3A4 inducer and will decrease serum concentrations of tolvaptan and ultimately, its clinical effects.
Topiramate	Increased phenytoin/decreased topiramate
Tramadol	Phenytoin may decrease the effect of Tramadol by increasing Tramadol metabolism and clearance.
Trazodone	The CYP3A4 inducer, Phenytoin, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Phenytoin is initiated, discontinued or dose changed.
Tretinoin	The strong CYP2C8 inducer, Phenytoin, may increase the metabolism and clearance of oral Tretinoin. Consider alternate therapy to avoid failure of Tretinoin therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Phenytoin is initiated, discontinued or dose changed.
Triamcinolone	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, triamcinolone.
Triazolam	Phenytoin may increase the metabolism of triazolam via CYP3A4.
Trimethoprim	Trimethoprim increases the effect of hydantoin
Trioxsalen	The hydantoin decreases the effect of psoralene
Triprolidine	The CNS depressants, Triprolidine and Phenytoin, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Tubocurarine	Phenytoin decreases the effect of the muscle relaxant
Ulipristal	Concomitant therapy with strong CYP3A4 inducers may decrease plasma concentrations of ulipristal and ultimately its effectiveness. Avoid combination therapy.
Vandetanib	Decreases levels of vandetanib by affecting CYP3A4 metabolism. Contraindicated.
Vecuronium	Phenytoin decreases the effect of the muscle relaxant
Vemurafenib	Strong CYP3A4 inducers may decrease levels of vemurafenib. Monitor concomitant therapy closely.
Verapamil	Verapamil may increase the serum concentration of Phenytoin by decreasing its metabolism. Monitor for changes in the therapeutic/adverse effects of Phenytoin if Verapamil is initiated, discontinued or dose changed.
Vigabatrin	Vigabatrin reduces plasma levels of phenytoin by 16-20% which may be due to induction of CYP2C. Consider dosage adjustment.
Vinblastine	The antineoplasic agent decreases the effect of hydantoin
Voriconazole	Voriconazole may increase the serum concentration of phenytoin by decreasing its metabolism. Phenytoin may increase the serum concentration of voriconazole by increasing its metabolism. Consider alternate antifungal therapy or monitor for voriconazole therapy failure and phenytoin toxicity.
Warfarin	Warfarin may increase the serum concentration of phenytoin possibly by competing for CYP2C9 metabolism. Phenytoin may increase the anticoagulant effect of warfarin. Monitor phenytoin levels, prothrombin time, and therapeutic and adverse effects of both agents during concomitant therapy.

Food Interactions

Avoid alcohol.
Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
Take with food to increase bioavailability and reduce irritation.

Sodium channel protein type 5 subunit alpha
Name	Sodium channel protein type 5 subunit alpha
Gene Name	SCN5A
Pharmacological action	yes
Actions	inhibitor
References	Lenkowski PW, Ko SH, Anderson JD, Brown ML, Patel MK: Block of human NaV1.5 sodium channels by novel alpha-hydroxyphenylamide analogues of phenytoin. Eur J Pharm Sci. 2004 Apr;21(5):635-44. - Pubmed Swadron SP, Rudis MI, Azimian K, Beringer P, Fort D, Orlinsky M: A comparison of phenytoin-loading techniques in the emergency department. Acad Emerg Med. 2004 Mar;11(3):244-52. - Pubmed
DTHybrid score	0.5307
Sodium channel protein type 1 subunit alpha
Name	Sodium channel protein type 1 subunit alpha
Gene Name	SCN1A
Pharmacological action	yes
Actions	inhibitor
References	Tate SK, Depondt C, Sisodiya SM, Cavalleri GL, Schorge S, Soranzo N, Thom M, Sen A, Shorvon SD, Sander JW, Wood NW, Goldstein DB: Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5507-12. Epub 2005 Apr 1. - Pubmed Tate SK, Singh R, Hung CC, Tai JJ, Depondt C, Cavalleri GL, Sisodiya SM, Goldstein DB, Liou HH: A common polymorphism in the SCN1A gene associates with phenytoin serum levels at maintenance dose. Pharmacogenet Genomics. 2006 Oct;16(10):721-726. - Pubmed Mantegazza M, Curia G, Biagini G, Ragsdale DS, Avoli M: Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol. 2010 Apr;9(4):413-24. - Pubmed
DTHybrid score	0.5364

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor,inducer
References	Levy RH: Cytochrome P450 isozymes and antiepileptic drug interactions. Epilepsia. 1995;36 Suppl 5:S8-13. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Tate SK, Depondt C, Sisodiya SM, Cavalleri GL, Schorge S, Soranzo N, Thom M, Sen A, Shorvon SD, Sander JW, Wood NW, Goldstein DB: Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5507-12. Epub 2005 Apr 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Komatsu T, Yamazaki H, Asahi S, Gillam EM, Guengerich FP, Nakajima M, Yokoi T: Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4. Drug Metab Dispos. 2000 Nov;28(11):1361-8. - Pubmed
DTHybrid score	0.6843
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inducer
References	Levy RH: Cytochrome P450 isozymes and antiepileptic drug interactions. Epilepsia. 1995;36 Suppl 5:S8-13. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Komatsu T, Yamazaki H, Asahi S, Gillam EM, Guengerich FP, Nakajima M, Yokoi T: Formation of a dihydroxy metabolite of phenytoin in human liver microsomes/cytosol: roles of cytochromes P450 2C9, 2C19, and 3A4. Drug Metab Dispos. 2000 Nov;28(11):1361-8. - Pubmed Kaminsky LS, Zhang ZY: Human P450 metabolism of warfarin. Pharmacol Ther. 1997;73(1):67-74. - Pubmed
DTHybrid score	0.6273
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5481
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inducer
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4693
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.9726
Cytochrome P450 2C18
Name	Cytochrome P450 2C18
Gene Name	CYP2C18
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2621
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5477
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4385
Cytochrome P450 11B1, mitochondrial
Name	Cytochrome P450 11B1, mitochondrial
Gene Name	CYP11B1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.2115

Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions	inhibitor
References	Westholm DE, Stenehjem DD, Rumbley JN, Drewes LR, Anderson GW: Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. Endocrinology. 2009 Feb;150(2):1025-32. Epub 2008 Oct 9. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.1373
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. - Pubmed Luna-Tortos C, Fedrowitz M, Loscher W: Several major antiepileptic drugs are substrates for human P-glycoprotein. Neuropharmacology. 2008 Dec;55(8):1364-75. Epub 2008 Sep 11. - Pubmed
DTHybrid score	0.6364
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	substrate
References	Baltes S, Gastens AM, Fedrowitz M, Potschka H, Kaever V, Loscher W: Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology. 2007 Feb;52(2):333-46. Epub 2006 Oct 10. - Pubmed
DTHybrid score	0.284

Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions
References	Not Available
DTHybrid score	0.1373
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.6364
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.284

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.4945
4200	Cytochrome P450 1A2	CYP1A2	0.3946
6013	Cytochrome P450 2E1	CYP2E1	0.2192
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1833
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1722
6024	Cytochrome P450 1A1	CYP1A1	0.1684
5718	Cytochrome P450 2A6	CYP2A6	0.1679
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.1654
20	Prostaglandin G/H synthase 1	PTGS1	0.1524
1181	Alpha-1-acid glycoprotein 1	ORM1	0.132
862	Multidrug resistance-associated protein 1	ABCC1	0.1213
1729	Solute carrier family 22 member 6	SLC22A6	0.1186
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.098
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0975
6145	Solute carrier family 22 member 1	SLC22A1	0.0936
6142	Solute carrier family 22 member 8	SLC22A8	0.0936
776	Bile salt export pump	ABCB11	0.0891
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0883
290	Prostaglandin G/H synthase 2	PTGS2	0.0879
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0864
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0824
3811	Cytochrome P450 19A1	CYP19A1	0.0819
6144	Solute carrier family 22 member 2	SLC22A2	0.0811
2164	Multidrug resistance-associated protein 4	ABCC4	0.08
824	Sodium-dependent serotonin transporter	SLC6A4	0.0779
118	Organic cation/carnitine transporter 2	SLC22A5	0.0744
492	Histamine H1 receptor	HRH1	0.0739
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0738
1898	Cytochrome P450 1B1	CYP1B1	0.0732
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0644
260	Cytochrome P450 51	ERG11	0.0626
761	Cytochrome P450 51	ERG11	0.0626
3163	Cytochrome P450 51	cyp51	0.0626
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0622
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0613
6143	Solute carrier family 22 member 7	SLC22A7	0.0611
831	D(2) dopamine receptor	DRD2	0.0604
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0592
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0575
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0571
136	Estrogen receptor	ESR1	0.0562
756	Sex hormone-binding globulin	SHBG	0.0559
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0555
847	Mu-type opioid receptor	OPRM1	0.0553
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0546
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0542
1024	Solute carrier family 22 member 11	SLC22A11	0.054
556	Alpha-1A adrenergic receptor	ADRA1A	0.0533
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0533
465	Calmodulin	CALM1	0.052
871	Glucocorticoid receptor	NR3C1	0.0508
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0507
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.05
6141	Sodium/bile acid cotransporter	SLC10A1	0.0495
380	Cytochrome P450 17A1	CYP17A1	0.0486
6031	Cytochrome P450 3A43	CYP3A43	0.0481
737	Mineralocorticoid receptor	NR3C2	0.0472
468	Cytochrome P450 4A11	CYP4A11	0.0466
731	HIV-1 protease	HIV-1 protease	0.0462
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0453
6148	Multidrug resistance-associated protein 7	ABCC10	0.0452
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0441
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0434
467	Delta-type opioid receptor	OPRD1	0.0432
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0431
6147	Solute carrier family 22 member 3	SLC22A3	0.0426
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0413
3923	Cholinesterase	BCHE	0.0411
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.041
51	Muscarinic acetylcholine receptor M3	CHRM3	0.041
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0401
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0401
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0399
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0398
891	Dihydropteroate synthase	folP	0.0395
5359	Dihydropteroate synthase	folP	0.0395
7175	Dihydropteroate synthase	sulI	0.0395
696	Kappa-type opioid receptor	OPRK1	0.0393
146	Androgen receptor	AR	0.0379
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0378
70	Type-1 angiotensin II receptor	AGTR1	0.0378
758	Thyroid hormone receptor alpha	THRA	0.0373
632	Alpha-1B adrenergic receptor	ADRA1B	0.037
833	Organic cation/carnitine transporter 1	SLC22A4	0.0369
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0369
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0363
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0363
269	Adrenodoxin, mitochondrial	FDX1	0.0358
318	Alpha-2A adrenergic receptor	ADRA2A	0.0357
817	DNA topoisomerase 2-alpha	TOP2A	0.0349
713	Sodium-dependent dopamine transporter	SLC6A3	0.0349
23	D(1A) dopamine receptor	DRD1	0.0348
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0343
232	Corticosteroid-binding globulin	SERPINA6	0.0342
614	Progesterone receptor	PGR	0.0329
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0327
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.032
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0317
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0317
346	Thyroid hormone receptor beta-1	THRB	0.0317
629	Alpha-2B adrenergic receptor	ADRA2B	0.0316
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0314
6136	Multidrug resistance-associated protein 5	ABCC5	0.0313
844	Epidermal growth factor receptor	EGFR	0.0312
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0311
6137	Multidrug resistance-associated protein 6	ABCC6	0.0311
592	Carbonic anhydrase 4	CA4	0.0308
122	P2Y purinoceptor 12	P2RY12	0.0307
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0306
275	Arachidonate 5-lipoxygenase	ALOX5	0.0304
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0303
6182	Cytochrome P450 2J2	CYP2J2	0.0303
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0298
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0298
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0297
766	Beta-2 adrenergic receptor	ADRB2	0.0295
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0294
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0294
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0294
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0291
373	Transthyretin	TTR	0.0286
3941	Amine oxidase [flavin-containing] A	MAOA	0.0284
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0284
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0283
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.028
4604	Liver carboxylesterase 1	CES1	0.0279
738	Monocarboxylate transporter 1	SLC16A1	0.0278
193	Beta-1 adrenergic receptor	ADRB1	0.0277
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0275
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0275
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0273
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0272
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0272
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0272
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0272
594	Thyroxine-binding globulin	SERPINA7	0.0272
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0269
789	Alpha-1D adrenergic receptor	ADRA1D	0.0267
357	Carbonic anhydrase 2	CA2	0.0261
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.026
94	5-hydroxytryptamine 4 receptor	HTR4	0.026
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0259
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0259
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0255
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0252
811	Translocator protein	TSPO	0.0251
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0242
6220	Aryl hydrocarbon receptor	AHR	0.0241
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0239
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0239
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0238
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0238
504	Mast/stem cell growth factor receptor	KIT	0.0238
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0237
638	D(3) dopamine receptor	DRD3	0.0237
3939	Amine oxidase [flavin-containing] B	MAOB	0.0235
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0228
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0227
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0225
477	DNA topoisomerase 4 subunit A	parC	0.0223
886	DNA topoisomerase 4 subunit A	parC	0.0223
6226	DNA topoisomerase 4 subunit A	parC	0.0223
6167	Organic solute transporter subunit beta	OSTB	0.022
6166	Organic solute transporter subunit alpha	OSTA	0.022
404	DNA gyrase subunit A	gyrA	0.0219
6224	DNA gyrase subunit A	gyrA	0.0219
4120	NADPH--cytochrome P450 reductase	POR	0.0219
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0217
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0216
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0213
6085	Fatty acid-binding protein, intestinal	FABP2	0.0209
33	Cystine/glutamate transporter	SLC7A11	0.0207
869	Estrogen receptor beta	ESR2	0.0203
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0203
1010	Cytochrome P450 51A1	CYP51A1	0.0201
6020	Aldehyde oxidase	AOX1	0.0199
378	Alpha-2C adrenergic receptor	ADRA2C	0.0196
26	Vascular endothelial growth factor receptor 3	FLT4	0.0194
29	Tubulin beta-1 chain	TUBB1	0.0193
172	Potassium channel subfamily K member 1	KCNK1	0.0191
469	Annexin A1	ANXA1	0.0191
407	Vascular endothelial growth factor receptor 2	KDR	0.0189
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0189
124	Histamine H2 receptor	HRH2	0.0187
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0186
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0185
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0185
32	Vascular endothelial growth factor receptor 1	FLT1	0.0185
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0184
6102	Arylamine N-acetyltransferase 2	NAT2	0.0182
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0182
161	Tubulin beta chain	TUBB	0.0182
312	Tubulin beta chain	TUB2	0.0182
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.018
921	Glutamate receptor 2	GRIA2	0.018
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0177
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0177
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0177
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0174
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0174
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0173
705	Glutamate receptor 1	GRIA1	0.0173
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0169
1389	Transforming growth factor beta-1	TGFB1	0.0169
818	50S ribosomal protein L10	rplJ	0.0167
777	Tumor necrosis factor	TNF	0.0165
1757	Myeloperoxidase	MPO	0.0165
24	Thymidylate synthase	TMP1	0.0165
359	Thymidylate synthase	TYMS	0.0165
2626	Thymidylate synthase	thyA	0.0165
2729	Thymidylate synthase	thyA	0.0165
5352	Thymidylate synthase	THYA	0.0165
563	Thyroid peroxidase	TPO	0.0164
6149	Solute carrier family 22 member 10	SLC22A10	0.0162
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0161
85	Growth hormone receptor	GHR	0.0156
199	Monocarboxylate transporter 8	SLC16A2	0.0155
427	Substance-P receptor	TACR1	0.0154
1656	CYP2B protein	CYP2B	0.0154
13	Aminomethyltransferase, mitochondrial	AMT	0.0154
482	Glycine receptor subunit alpha-1	GLRA1	0.0154
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0151
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0149
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0147
295	Carbonic anhydrase 1	CA1	0.0145
952	Dipeptidyl peptidase 4	DPP4	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0141
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0138
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0138
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0136
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0136
716	5-hydroxytryptamine 7 receptor	HTR7	0.0135
6174	50S ribosomal protein L32	rpmF	0.0134
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0133
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0133
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0132
365	Dihydrofolate reductase	DHFR	0.0131
2381	Dihydrofolate reductase	DFR1	0.0131
2833	Dihydrofolate reductase	Not Available	0.0131
2931	Dihydrofolate reductase	folA	0.0131
3544	Dihydrofolate reductase	folA	0.0131
3682	Dihydrofolate reductase	folA	0.0131
6642	Dihydrofolate reductase	folA	0.0131
6756	Dihydrofolate reductase	dfrA	0.0131
2539	Tubulin alpha-1 chain	TUBA4A	0.0131
185	Vasopressin V1a receptor	AVPR1A	0.0131
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.013
2808	Chloramphenicol acetyltransferase 3	cat3	0.013
432	D(4) dopamine receptor	DRD4	0.0128
2298	Cytochrome P450-cam	camC	0.0128
322	Vasopressin V2 receptor	AVPR2	0.0128
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0126
84	Nuclear receptor 0B1	NR0B1	0.0125
165	FL cytokine receptor	FLT3	0.0125
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0125
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0124
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0124
88	Retinoic acid receptor RXR-beta	RXRB	0.0123
174	Sigma 1-type opioid receptor	SIGMAR1	0.0123
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0123
1852	Microtubule-associated protein 2	MAP2	0.0122
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0121
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0121
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0121
233	Potassium channel subfamily K member 2	KCNK2	0.012
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.012
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.012
768	FK506-binding protein 1A	FKBP1A	0.012
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0118
1192	Sulfotransferase 1A1	SULT1A1	0.0118
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0117
273	Apoptosis regulator Bcl-2	BCL2	0.0116
5934	Cytochrome P450 26A1	CYP26A1	0.0116
558	Solute carrier family 12 member 1	SLC12A1	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
2211	Fatty acid-binding protein, heart	FABP3	0.0114
3808	Dihydropteroate synthase 2	folP2	0.0113
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0113
3601	Dihydropteroate synthase 1	folP1	0.0113
3807	Dihydropteroate synthase 1	folP1	0.0113
183	Vascular endothelial growth factor A	VEGFA	0.0113
1353	DNA topoisomerase 1	TOP1	0.0113
3552	DNA topoisomerase 1	topA	0.0113
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0113
6126	Carbonic anhydrase 7	CA7	0.0112
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
780	Retinoic acid receptor RXR-gamma	RXRG	0.0112
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0108
904	Glutathione S-transferase P	GSTP1	0.0108
3810	Catechol O-methyltransferase	COMT	0.0108
2443	Azurin	azu	0.0108
3932	Glutathione S-transferase A2	GSTA2	0.0108
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0107
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0107
3947	Xanthine dehydrogenase/oxidase	XDH	0.0106
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0105
6432	Transporter	snf	0.0105
5923	Microtubule-associated protein tau	MAPT	0.0104
5924	Microtubule-associated protein 4	MAP4	0.0104
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0103
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0103
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0103
6014	Cytochrome P450 2A13	CYP2A13	0.0101
6151	Monocarboxylate transporter 10	SLC16A10	0.01
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0099
6135	Sodium channel subunit beta-4	SCN4B	0.0099
6133	Sodium channel subunit beta-2	SCN2B	0.0099
6134	Sodium channel subunit beta-3	SCN3B	0.0099
6132	Sodium channel subunit beta-1	SCN1B	0.0099
6127	Carbonic anhydrase-related protein	CA8	0.0099
6129	Carbonic anhydrase-related protein 11	CA11	0.0099
6128	Carbonic anhydrase-related protein 10	CA10	0.0099
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0099
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0099
1618	High affinity nerve growth factor receptor	NTRK1	0.0098
3426	Glutamine synthetase	glnA	0.0097
3987	Glutamine synthetase	GLUL	0.0097
4116	Dihydropteroate synthetase	Not Available	0.0097
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0097
162	Retinoic acid receptor gamma-1	RARG	0.0097
5300	Antigen peptide transporter 1	TAP1	0.0096
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0096
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
49	Endothelin B receptor	EDNRB	0.0096
1629	Transcription factor AP-1	JUN	0.0095
4237	50S ribosomal protein L22	rplV	0.0095
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0095
566	Serotransferrin	TF	0.0094
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0094
319	Opioid receptor, sigma 1	OPRS1	0.0094
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0094
908	Glutathione S-transferase theta-1	GSTT1	0.0094
1050	Bile salt sulfotransferase	SULT2A1	0.0093
1630	Integrin beta-2	ITGB2	0.0093
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0093
7	Nitric oxide synthase, inducible	NOS2	0.0092
6218	Pannexin-1	PANX1	0.0092
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0092
578	Endothelin-1 receptor	EDNRA	0.009
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0088
6131	Carbonic anhydrase 14	CA14	0.0088
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0087
6130	Carbonic anhydrase 13	CA13	0.0087
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0087
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0087
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0087
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0086
131	Synaptic vesicular amine transporter	SLC18A2	0.0086
6138	Multidrug resistance protein 3	ABCB4	0.0086
1650	Heme carrier protein 1	SLC46A1	0.0086
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0085
6146	High affinity copper uptake protein 1	SLC31A1	0.0085
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0085
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0085
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0085
474	Acetylcholinesterase	ACHE	0.0084
244	Angiotensin-converting enzyme	ACE	0.0084
719	Retinoic acid receptor responder protein 1	RARRES1	0.0083
770	Retinoic acid-induced protein 3	GPRC5A	0.0083
6122	Carbonic anhydrase 3	CA3	0.0083
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0083
4238	50S ribosomal protein L4	rplD	0.0083
5578	50S ribosomal protein L4	rplD	0.0083
6173	50S ribosomal protein L4	rplD	0.0083
6219	50S ribosomal protein L4	rplD	0.0083
850	Vasopressin V1b receptor	AVPR1B	0.0081
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0081
239	Coagulation factor X	F10	0.0081
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0081
823	Fibroblast growth factor receptor 2	FGFR2	0.0081
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0081
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0081
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0081
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0081
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0081
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0081
1196	Complement decay-accelerating factor	CD55	0.008
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
489	Monocarboxylate transporter 2	SLC16A7	0.0079
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
4122	Histone deacetylase 2	HDAC2	0.0077
814	Ryanodine receptor 1	RYR1	0.0077
6043	Putative G-protein coupled receptor 44	GPR44	0.0077
4203	Histamine N-methyltransferase	HNMT	0.0077
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0077
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0077
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0076
751	Potassium channel subfamily K member 6	KCNK6	0.0075
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0074
1541	Metalloproteinase	mmp20	0.0074
2449	Tubulin alpha-3 chain	TUBA1A	0.0074
284	DNA-directed RNA polymerase beta chain	rpoB	0.0074
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0074
5787	Angiopoietin-1 receptor	TEK	0.0073
569	Retinal dehydrogenase 2	ALDH1A2	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
3809	Estrogen-related receptor gamma	ESRRG	0.0071
54	Prothrombin	F2	0.0071
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
163	D(1B) dopamine receptor	DRD5	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
3917	Methylenetetrahydrofolate reductase	MTHFR	0.007
459	Retinoic acid receptor RXR-alpha	RXRA	0.007
4205	Carbonic anhydrase 9	CA9	0.0069
3007	Carbonic anhydrase 12	CA12	0.0069
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0069
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0069
1525	Heparin-binding growth factor 2	FGF2	0.0069
1517	Beta-3 adrenergic receptor	ADRB3	0.0069
4773	Deoxycytidine kinase	DCK	0.0068
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
611	Retinal dehydrogenase 1	ALDH1A1	0.0068
68	Cannabinoid receptor 1	CNR1	0.0068
1483	Membrane copper amine oxidase	AOC3	0.0067
1178	Adenosine A2a receptor	ADORA2A	0.0067
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0067
36	Insulin receptor	INSR	0.0066
3587	Gastrotropin	FABP6	0.0066
856	Vitamin D3 receptor	VDR	0.0066
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0066
6044	Serum paraoxonase/lactonase 3	PON3	0.0065
1992	Vitamin D-binding protein	GC	0.0065
4192	DNA topoisomerase 2-beta	TOP2B	0.0064
5818	Folate receptor alpha	FOLR1	0.0064
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
133	Dihydropterate synthase	sulI	0.0063
3270	Elongation factor G	fusA	0.0062
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
896	Glutathione S-transferase Mu 1	GSTM1	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
3937	Fatty-acid amide hydrolase	FAAH	0.0062
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0062
6163	Copper-transporting ATPase 2	ATP7B	0.0061
6165	Copper-transporting ATPase 1	ATP7A	0.0061
1039	Histone deacetylase 9	HDAC9	0.0061
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0061
3868	Calcineurin subunit B isoform 2	PPP3R2	0.006
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.006
572	Integrin alpha-L	ITGAL	0.006
976	Platelet glycoprotein IX	GP9	0.006
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.006
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0059
6103	Arylamine N-acetyltransferase 1	NAT1	0.0059
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
2232	Interleukin-5	IL5	0.0059
16	Adenosine A1 receptor	ADORA1	0.0059
1593	Mucin-2	MUC2	0.0059
291	Nitric-oxide synthase, endothelial	NOS3	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
581	Cytochrome P450 2R1	CYP2R1	0.0058
518	Peroxidase/catalase T	katG	0.0058
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0057
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0057
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
153	Dopamine beta-hydroxylase	DBH	0.0057
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0057
4311	tRNA	TRDMT1	0.0056
4325	tRNA	trmD	0.0056
4328	tRNA	trmD	0.0056
293	Gamma-glutamyl hydrolase	GGH	0.0056
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0055
461	Glycine receptor subunit alpha-3	GLRA3	0.0054
5626	Nucleoside diphosphate kinase B	NME2	0.0054
3086	Plasmepsin-2	Not Available	0.0053
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0053
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0053
2112	Toll-like receptor 9	TLR9	0.0053
4103	Proteasome subunit beta type 2	PSMB2	0.0052
4102	Proteasome subunit beta type 5	PSMB5	0.0052
4101	Proteasome subunit beta type 1	PSMB1	0.0052
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0052
3913	Glutamic acid decarboxylase	GAD65	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
1714	Mitogen-activated protein kinase 3	MAPK3	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0051
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.005
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.005
1275	Estrogen sulfotransferase	SULT1E1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0049
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0049
267	Plasminogen activator inhibitor 1	SERPINE1	0.0049
1123	Eosinophil cationic protein	RNASE3	0.0049
229	Retinoic acid receptor beta	RARB	0.0049
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0049
4210	Toll-like receptor 4	TLR4	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0048
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0048
730	Retinoic acid receptor alpha	RARA	0.0048
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0047
6677	Myelin P2 protein	PMP2	0.0047
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0047
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0047
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0047
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0046
3856	Fibroblast growth factor receptor 3	FGFR3	0.0046
1648	Elastin	ELN	0.0046
4217	Telomerase reverse transcriptase	TERT	0.0046
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0046
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0046
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0046
936	Ephrin type-A receptor 2	EPHA2	0.0046
1864	RET proto-oncogene	RET	0.0046
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0045
1291	cAMP response element-binding protein	CREB1	0.0045
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0045
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0045
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
2599	Tyrosine-protein kinase HCK	HCK	0.0044
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0044
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0044
6048	Troponin C, skeletal muscle	TNNC2	0.0044
1262	Corticotropin-lipotropin	POMC	0.0044
6221	Steroid hormone receptor ERR1	ESRRA	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5294	Nucleoside diphosphate kinase A	NME1	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
6033	High affinity interleukin-8 receptor A	CXCR1	0.0044
3904	Alanine aminotransferase 2	GPT2	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0042
65	Matrix metalloproteinase-9	Not Available	0.0042
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0042
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0042
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0041
1569	G1/S-specific cyclin-D1	CCND1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
106	Cannabinoid receptor 2	CNR2	0.004
6824	Tyrosine-protein kinase Lyn	LYN	0.004
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4161	Furin	FURIN	0.004
634	Squalene monooxygenase	SQLE	0.004
7196	Squalene monooxygenase	ERG1	0.004
2207	Rhodopsin	RHO	0.004
1760	Aminopeptidase N	ANPEP	0.0039
6843	Aminopeptidase N	pepN	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
117	Sterol O-acyltransferase 1	SOAT1	0.0038
6211	Tubulin epsilon chain	TUBE1	0.0037
6210	Tubulin delta chain	TUBD1	0.0037
6212	Tubulin gamma-1 chain	TUBG1	0.0037
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0037
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0037
5798	Mitogen-activated protein kinase 11	MAPK11	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
2320	Thymidine kinase, cytosolic	TK1	0.0036
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0036
6837	Serine/threonine-protein kinase 17B	STK17B	0.0036
605	Fumarate reductase flavoprotein subunit	frdA	0.0035
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0035
3673	Fumarate reductase flavoprotein subunit	fccA	0.0035
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0035
6549	Fumarate reductase flavoprotein subunit	frdA	0.0035
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0035
2021	Thrombomodulin	THBD	0.0035
939	50S ribosomal protein L3	rplC	0.0035
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0034
3639	Thymidine phosphorylase	deoA	0.0034
3936	Thymidine phosphorylase	TYMP	0.0034
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0034
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0033
6459	Glycodelin	PAEP	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0033
1867	Major prion protein	PRNP	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6042	Prostaglandin reductase 2	PTGR2	0.0031
702	UMP-CMP kinase	CMPK1	0.0031
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
6501	Fatty acid-binding protein, liver	FABP1	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
517	Alcohol dehydrogenase 1C	ADH1C	0.003
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.003
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
283	SEC14-like protein 2	SEC14L2	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
1313	Lactoylglutathione lyase	GLO1	0.0029
444	Alcohol dehydrogenase 1B	ADH1B	0.0029
2216	Fibroblast growth factor receptor 4	FGFR4	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
251	Alcohol dehydrogenase 1A	ADH1A	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0028
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
4226	Uridine phosphorylase 2	UPP2	0.0028
164	Histamine H4 receptor	HRH4	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
1176	Mitogen-activated protein kinase 1	MAPK1	0.0027
484	Tyrosine-protein kinase ABL2	ABL2	0.0027
820	Glycine receptor subunit alpha-2	GLRA2	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0027
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0027
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
4225	Uridine phosphorylase 1	UPP1	0.0026
992	Protein tyrosine kinase 2 beta	PTK2B	0.0026
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0026
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
1268	Neuropeptide S receptor	NPSR1	0.0025
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0025
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0025
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0025
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0024
1792	Tissue-type plasminogen activator	PLAT	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
413	Amidophosphoribosyltransferase	PPAT	0.0024
2515	Amidophosphoribosyltransferase	purF	0.0024
3714	Amidophosphoribosyltransferase	purF	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0024
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0024
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0024
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0024
6168	Solute carrier family 22 member 16	SLC22A16	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
76	Nitric-oxide synthase, brain	NOS1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0023
6073	Potassium channel subfamily K member 9	KCNK9	0.0023
6072	Potassium channel subfamily K member 3	KCNK3	0.0023
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0023
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
4948	Cytochrome c-553	Not Available	0.0021
4923	Cytochrome c3	DvMF_2499	0.0021
4945	Cytochrome c3	Not Available	0.0021
4949	Cytochrome c3	DVU_3171	0.0021
4968	Cytochrome c3	cytc3	0.0021
4997	Cytochrome c3	SO_2727	0.0021
5219	Cytochrome c3	cyd	0.0021
4902	Nine-heme cytochrome c	Ddes_2038	0.0021
3189	High-molecular-weight cytochrome c	hmcA	0.0021
3957	Adenosine deaminase	ADA	0.0021
3221	Cytochrome c4	cc4	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
4954	Soluble cytochrome b558	Not Available	0.0021
4925	Cytochrome c-type protein SHP	shp	0.0021
4934	Cytochrome c-551	nirM	0.0021
5218	Cytochrome c-551	nirM	0.0021
4943	Cytochrome c6	petJ	0.0021
4947	Bacterial hemoglobin	vhb	0.0021
4905	Cytochrome c2	Not Available	0.0021
4939	Cytochrome c2	cycA	0.0021
4964	Cytochrome c2	cycA	0.0021
4979	Cytochrome c2	cycA	0.0021
6673	Cytochrome c2	cycA	0.0021
4915	Cytochrome c-550	psbV	0.0021
4959	Cytochrome c-550	psbV	0.0021
5216	Cytochrome c-550	psbV	0.0021
4916	Cyanoglobin	glbN	0.0021
4975	Cytochrome c-556	RPA3973	0.0021
4984	Neuroglobin	NGB	0.0021
4998	Hemoglobin-like protein yjbI	yjbI	0.0021
4994	Hemoglobin-like protein HbO	glbO	0.0021
4936	Cytochrome c2 iso-2	Not Available	0.0021
4909	CooA protein	cooA	0.0021
4942	Diheme cytochrome c napB	napB	0.0021
4907	Cytochrome c-L	moxG	0.0021
6865	Cytochrome c-L	moxG	0.0021
5000	HemO	hemO	0.0021
4981	Iron-starvation protein PigA	pigA	0.0021
644	Heme oxygenase 2	HMOX2	0.0021
4982	Heme oxygenase 2	pbsA2	0.0021
4935	Cytochrome c-554	cycA1	0.0021
4910	Cytoglobin	CYGB	0.0021
4961	Hemophore HasA	hasA	0.0021
4971	Nonaheme cytochrome c	hmcA	0.0021
4904	Cytochrome c family protein	GSU1996	0.0021
4976	Apocytochrome f	petA	0.0021
6407	Apocytochrome f	petA	0.0021
4989	Cytochrome c551 peroxidase	ccp	0.0021
5222	Cytochrome c551 peroxidase	ccpA	0.0021
4931	Cytochrome P450 167A1	CYP167A1	0.0021
4999	Cytochrome P450 165B3	CYP165B3	0.0021
4764	Cytochrome P450 165C4	CYP165C4	0.0021
4960	Putative cytochrome P450-family protein	SCO7417	0.0021
4937	Cytochrome oxidase subunit II	rcoxA	0.0021
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0021
4903	Methyl-accepting chemotaxis protein	Tar4	0.0021
4972	P450cin	cinA	0.0021
4993	Hydroxylamine oxidoreductase	hao1	0.0021
4922	Cytochrome c, putative	SO_4144	0.0021
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0021
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0021
3093	Catalase HPII	katE	0.0021
4952	Catalase/peroxidase	katA	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
1253	Interferon gamma	IFNG	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
4386	Hemoglobin-like protein HbN	glbN	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
268	Adenosine A2b receptor	ADORA2B	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
3830	Calreticulin	CALR	0.0017
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
4041	Microsomal glutathione S-transferase 2	MGST2	0.0016
173	Toll-like receptor 7	TLR7	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
3233	Bile acid receptor	NR1H4	0.0015
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0015
4920	Peroxidase/catalase	katG	0.0015
2119	Cytochrome b5	CYB5A	0.0015
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0015
4990	PpcA	ppcA	0.0015
3375	Acidic cytochrome c3	Not Available	0.0015
4988	Sulfite oxidase, mitochondrial	SUOX	0.0015
4385	Cytochrome c'	Not Available	0.0015
4967	Cytochrome c'	cycA	0.0015
5038	Cytochrome c'	Not Available	0.0015
5223	Cytochrome c'	cycP	0.0015
2915	Sensor protein fixL	fixL	0.0015
4944	Sensor protein fixL	fixL	0.0015
3570	Cytochrome P450 152A1	cypC	0.0015
4992	Cytochrome c peroxidase	Not Available	0.0015
4813	Heme oxygenase	hmuO	0.0015
5769	Heme oxygenase	Not Available	0.0015
4289	Cytochrome P450	TT_P0059	0.0015
6262	Cytochrome P450	staP	0.0015
340	Apoptotic protease-activating factor 1	APAF1	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
2230	Catalase	CAT	0.0015
3249	Catalase	katA	0.0015
3625	Catalase	katA	0.0015
4539	Catalase	katA	0.0015
4941	Catalase	katB	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
2391	Ferrochelatase	hemH	0.0014
6502	Ferrochelatase	DKFZp686P18130	0.0014
1591	Ferrochelatase, mitochondrial	FECH	0.0014
760	Fibroblast growth factor 1	FGF1	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1507	Cytochrome c	CYCS	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
825	Arsenical pump-driving ATPase	ASNA1	0.0013
3435	Arsenical pump-driving ATPase	arsA	0.0013
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0013
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0013
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0013
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0013
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0013
733	Activin receptor type 1B	ACVR1B	0.0013
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0013
154	AFG3-like protein 2	AFG3L2	0.0013
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0013
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0013
395	ALK tyrosine kinase receptor	Not Available	0.0013
3670	Soluble cytochrome b562 precursor	cybC	0.0013
3411	Cytochrome P450 121	cyp121	0.0013
3291	Cytochrome c-552	cycA	0.0013
4927	Cytochrome c-552	nrfA	0.0013
4938	Cytochrome c-552	cycA	0.0013
4953	Cytochrome c-552	nrfA	0.0013
5217	Cytochrome c-552	cycM	0.0013
2617	Nitric oxide synthase oxygenase	nos	0.0013
2701	Nitric oxide synthase oxygenase	nos	0.0013
3102	Flavohemoprotein	hmp	0.0013
4969	Flavohemoprotein	hmp	0.0013
4031	Glutathione S-transferase A1	GSTA1	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
822	Aldose reductase	AKR1B1	0.0012
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0012
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0012
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0012
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0012
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0012
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0012
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0012
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0012
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0012
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0012
6559	Cytochrome c oxidase subunit 2	ctaC	0.0012
6669	Cytochrome c oxidase subunit 2	ctaC	0.0012
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0012
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0012
6558	Cytochrome c oxidase subunit 1	ctaD	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
292	Activin receptor type-1	ACVR1	0.0012
1295	Fatty acid synthase	FASN	0.0012
849	Activated CDC42 kinase 1	TNK2	0.0012
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0012
6859	Protein S100-A4	S100A4	0.0012
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0012
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0011
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0011
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0011
297	Adenylate cyclase type 1	ADCY1	0.0011
2540	Choloylglycine hydrolase	cbh	0.0011
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4608	Putative cytochrome P450	SCO1207	0.0011
4963	Putative cytochrome P450	SCO2884	0.0011
6254	Putative cytochrome P450	SCO6998	0.0011
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
358	Cystathionine beta-synthase	CBS	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
693	Hemoglobin subunit beta	HBB	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
740	Argininosuccinate synthase	ASS1	0.001
865	Argininosuccinate synthase	ASS1	0.001
2680	Argininosuccinate synthase	argG	0.001
3194	Argininosuccinate synthase	argG	0.001
661	ADP/ATP translocase 1	SLC25A4	0.0009
6021	Adenosine kinase	ADK	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
6268	Hydroxyacid oxidase 1	HAO1	0.0009
6228	Nuclear receptor coactivator 1	NCOA1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
810	Heme oxygenase 1	HMOX1	0.0009
3391	Heme oxygenase 1	pbsA1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6500	Phospholipase A2	PLA2G1B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0007
4034	Glutaredoxin-1	GLRX	0.0007
910	Epididymal secretory glutathione peroxidase	GPX5	0.0007
903	Glutathione S-transferase A5	GSTA5	0.0007
4037	Hypothetical protein	GPX1	0.0007
4297	Hypothetical protein	SP_1951	0.0007
4521	Hypothetical protein	BC_2969	0.0007
4540	Hypothetical protein	TM_1070	0.0007
4555	Hypothetical protein	MT1739	0.0007
4569	Hypothetical protein	mshD	0.0007
4578	Hypothetical protein	PA3270	0.0007
4747	Hypothetical protein	PA3967	0.0007
5177	Hypothetical protein	TM_0096	0.0007
5194	Hypothetical protein	PA1204	0.0007
5240	Hypothetical protein	Rv2991	0.0007
5370	Hypothetical protein	TM_1158	0.0007
5710	Hypothetical protein	Tb927.5.1360	0.0007
1928	Leukotriene C4 synthase	LTC4S	0.0007
4029	Microsomal glutathione S-transferase 3	MGST3	0.0007
4032	Microsomal glutathione S-transferase 1	MGST1	0.0007
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0007
4040	Glutathione peroxidase 7	GPX7	0.0007
907	Glutathione peroxidase 2	GPX2	0.0007
4038	Glutathione peroxidase 4	GPX4	0.0007
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0007
906	Glutathione peroxidase 1	GPX1	0.0007
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0007
4035	Glutathione S-transferase Mu 5	GSTM5	0.0007
4036	Glutathione peroxidase 6	GPX6	0.0007
900	Glutathione S-transferase A4	GSTA4	0.0007
911	Glutathione peroxidase 3	GPX3	0.0007
4042	Glutathione transferase omega-2	GSTO2	0.0007
4033	S-formylglutathione hydrolase	ESD	0.0007
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0007
125	DNA polymerase beta	POLB	0.0007
898	Glutathione S-transferase A3	GSTA3	0.0007
897	Glutathione S-transferase kappa 1	GSTK1	0.0007
909	Maleylacetoacetate isomerase	GSTZ1	0.0007
899	Glutathione S-transferase Mu 3	GSTM3	0.0006
905	Glutathione transferase omega-1	GSTO1	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
2165	Glutathione S-transferase Mu 2	GSTM2	0.0006
207	Glutathione synthetase	GSS	0.0006
5269	Glutathione synthetase	gshB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
901	Glutathione S-transferase Mu 4	GSTM4	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
714	Glutathione reductase, mitochondrial	GSR	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
2802	Endoglucanase G	celCCG	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00252 - Phenytoin

Targets

Enzymes

Transporters

Carriers

Predictions