DT-Web

DB01303 - Oxtriphylline


Identification
Name Oxtriphylline
Accession Number DB01303
Type small molecule
Description Oxtriphylline is the choline salt form of theophylline. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Its main physiological reponse is to dilate the bronchioles. As such, oxytriphylline is indicated mainly for asthma, bronchospasm, and COPD (i.e. all the same indications as the other theophyllines). It is marketed under the name Choledyl SA, and several forms of oxytriphylline have been discontinued. In the US, oxtriphylline is no longer available.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 283.3268
Groups approved
Monoisotopic Weight 283.164439563
Pharmacology
Indication Used to treat the symptoms of asthma, bronchitis, COPD, and emphysema.
Mechanism of action Oxtriphylline is a choline salt of theophylline. After ingestion, theophylline is released from oxytriphylline, and theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory states, theophylline activates histone deacetylase to prevent transcription of inflammatory genes that require the acetylation of histones for transcription to begin.
Absorption After ingestion, theophylline is released from oxytriphylline in the acidic environment of the stomach.
Protein binding With a serum concentrations of 17 mcg/mL, adults and children have about 56% theophylline bound to plasma protein, and premature infants have about 36%.
Biotransformation Theophylline undergoes hepatic metabolism to 1,3-dimethyluric acid, 1-methyluric acid, and 3-methylxanthine.
Route of elimination The kidneys are the main route of elimination for both theophylline and its metabolites, but some unchanged theophylline is eliminated in the feces.
Toxicity Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing).
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acyclovir Aciclovir may increase the effect and toxicity of oxtriphylline.
Adenosine This xanthine decreases the effect of adenosine
Amobarbital The barbiturate, amobarbital, decreases the effect of oxtriphylline.
Aprobarbital The barbiturate, aprobarbital, decreases the effect of oxtriphylline.
Atracurium Theophylline decreases the effect of muscle relaxant
Butabarbital The barbiturate, butabarbital, decreases the effect of oxtriphylline.
Butalbital The barbiturate, butalbital, decreases the effect of oxtriphylline.
Butethal The barbiturate, butethal, decreases the effect of oxtriphylline.
Carbamazepine Carbamazepine may decrease the serum concentration of oxtriphylline. Oxtriphylline may decrease the serum concentration of carbamazepine. Monitor for changes in the therapeutic effect of both agents if concomitant therapy is initiated, discontinued or dose changed.
Carteolol Antagonism of action and increased effect of theophylline
Cimetidine Cimetidine may increase the serum concentration of oxtriphylline by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of oxtriphylline if cimetidine is initiated, discontinued or dose changed.
Ciprofloxacin Ciprofloxacin may increase the effect of oxtriphylline.
Clarithromycin Clarithromycin may increase the effect and toxicity of oxtriphylline.
Dihydroquinidine barbiturate The barbiturate, dihydroquinidine barbiturate, decreases the effect of oxtriphylline.
Disulfiram Disulfiram may increase the effect and toxicity of oxtriphylline.
Doxacurium chloride Theophylline decreases the effect of muscle relaxant
Enoxacin Enoxacin may increase the effect of oxtriphylline.
Erythromycin The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Ethinyl Estradiol The contraceptive increases the effect and toxicity of theophylline
Ethotoin Decreased effect of both products
Fluvoxamine Fluvoxamine may increase the therapeutic and adverse effects of oxtriphylline.
Fosphenytoin Decreased effect of both products
Grepafloxacin Grepafloxacin may increase the effect of oxtriphylline.
Halothane Increased risk of cardiac arrhythmia
Heptabarbital The barbiturate, heptabarbital, decreases the effect of oxtriphylline.
Hexobarbital The barbiturate, hexobarbital, decreases the effect of oxtriphylline.
Interferon Alfa-2a, Recombinant Interferon increases the effect and toxicity of theophylline
Interferon Alfa-2b, Recombinant Interferon increases the effect and toxicity of theophylline
Interferon alfa-n1 Interferon increases the effect and toxicity of theophylline
Isoniazid Isoniazid may increase the effect and toxicity of oxtriphylline.
Josamycin The macrolide, josamycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Lithium Theophylline decreases serum levels of lithium
Mephenytoin Decreased effect of both products
Mestranol The contraceptive increases the effect and toxicity of theophylline
Methohexital The barbiturate, methohexital, decreases the effect of oxtriphylline.
Methylphenobarbital The barbiturate, methylphenobarbital, decreases the effect of oxtriphylline.
Metocurine Theophylline decreases the effect of muscle relaxant
Mexiletine Mexiletine increases the effect and toxicity of theophylline
Mivacurium Theophylline decreases the effect of muscle relaxant
Nadolol Antagonism of action and increased effect of theophylline
Norfloxacin Norfloxacin may increase the effect of oxtriphylline.
Pancuronium Theophylline decreases the effect of muscle relaxant
Pefloxacin Pefloxacin may increase the effect of oxtriphylline.
Peginterferon alfa-2a Interferon increases the effect and toxicity of theophylline
Peginterferon alfa-2b Interferon increases the effect and toxicity of theophylline
Penbutolol Antagonism of action and increased effect of theophylline
Pentobarbital The barbiturate, pentobarbital, decreases the effect of oxtriphylline.
Pentoxifylline Pentoxifylline increases the effect and toxicity of theophylline
Phenobarbital The barbiturate, phenobarbital, decreases the effect of oxtriphylline.
Phenytoin Decreased effect of both products
Pindolol Antagonism of action and increased effect of theophylline
Primidone The barbiturate, primidone, decreases the effect of oxtriphylline.
Propafenone Propafenone increases the effect of theophylline
Propranolol Antagonism of action and increased effect of theophylline
Quinidine barbiturate The barbiturate, quinidine barbiturate, decreases the effect of oxtriphylline.
Rifampin Rifampin may decrease the effect and toxicity of oxtriphylline.
Ritonavir Ritonavir decreases the effect of theophylline
Rofecoxib Rofecoxib increases the effect and toxicity of theophylline
Secobarbital The barbiturate, secobarbital, decreases the effect of oxtriphylline.
Sotalol Antagonism of action and increased effect of theophylline
St. John's Wort St. John's Wort decreases the effect of theophylline
Tacrine Tacrine increases the effect and toxicity of theophylline
Talbutal The barbiturate, talbutal, decreases the effect of oxtriphylline.
Terbinafine Terbinafine increases the effect and toxicity of theophylline
Thiabendazole Thiabendazole increases the effect and toxicity of theophylline
Ticlopidine Ticlopidine increases the effect and toxicity of theophylline
Timolol Antagonism of action and increased effect of theophylline
Troleandomycin The macrolide, troleandomycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.
Tubocurarine Theophylline decreases the effect of muscle relaxant
Vecuronium Theophylline decreases the effect of muscle relaxant
Verapamil Verapamil increases the effect of theophylline
Zileuton Zileuton increases the effect and toxicity of theophylline
Food Interactions
  • Avoid high doses of caffeine.
  • Take with food to reduce irritation.

Targets


cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Name cGMP-inhibited 3',5'-cyclic phosphodiesterase A
Gene Name PDE3A
Pharmacological action yes
Actions inhibitor
References
  • Rickards KJ, Andrews MJ, Waterworth TH, Alexander GB, Cunningham FM: Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation. J Vet Pharmacol Ther. 2003 Aug;26(4):277-82. - Pubmed
  • Wu BN, Lin RJ, Lo YC, Shen KP, Wang CC, Lin YT, Chen IJ: KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels. Br J Pharmacol. 2004 Aug;142(7):1105-14. Epub 2004 Jul 5. - Pubmed
  • Kajikawa S, Kigami D, Nakayama H, Doi K: Changes in submaxillary gland gene expression in F344 rats by multiple dosing of theophylline. Exp Anim. 2006 Apr;55(2):143-6. - Pubmed
DTHybrid score Not Available
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Gene Name PDE4A
Pharmacological action yes
Actions inhibitor
References
  • Wang K, Chen JQ, Chen Z, Chen JC: Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45. Acta Pharmacol Sin. 2002 Nov;23(11):1013-7. - Pubmed
  • Haider S: Cyclic AMP level and phosphodiesterase activity during 17alpha,20beta-dihydroxy-4-pregnen-3-one induction and theophylline inhibition of oocyte maturation in the catfish, Clarias batrachus. Comp Biochem Physiol A Mol Integr Physiol. 2003 Feb;134(2):267-74. - Pubmed
  • Rickards KJ, Andrews MJ, Waterworth TH, Alexander GB, Cunningham FM: Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation. J Vet Pharmacol Ther. 2003 Aug;26(4):277-82. - Pubmed
  • Usta C, Sadan G, Tuncel B: The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations. Prostaglandins Leukot Essent Fatty Acids. 2004 Sep;71(3):137-41. - Pubmed
  • Lee JM, Zemans RL, Hejazi M, Chin BB, Ladenson PW, Caturegli P: Modulation of thyroidal radioiodine uptake by theophylline. Exp Mol Pathol. 2004 Oct;77(2):116-20. - Pubmed
DTHybrid score Not Available
Adenosine A2a receptor
Name Adenosine A2a receptor
Gene Name ADORA2A
Pharmacological action yes
Actions antagonist
References
  • Pechlivanova DM, Georgiev VP: Effects of single and long-term theophylline treatment on the threshold of mechanical nociception: contribution of adenosine A1 and alpha2-adrenoceptors. Methods Find Exp Clin Pharmacol. 2005 Nov;27(9):659-64. - Pubmed
  • Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. - Pubmed
DTHybrid score 0.7896
Adenosine A1 receptor
Name Adenosine A1 receptor
Gene Name ADORA1
Pharmacological action yes
Actions antagonist
References
  • Nantwi KD, Basura GJ, Goshgarian HG: Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection. J Spinal Cord Med. 2003 Winter;26(4):364-71. - Pubmed
  • Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. - Pubmed
DTHybrid score 0.5873
Histone deacetylase 2
Name Histone deacetylase 2
Gene Name HDAC2
Pharmacological action yes
Actions activator
References
  • Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM, Barnes PJ: Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med. 2004 Sep 6;200(5):689-95. Epub 2004 Aug 30. - Pubmed
  • Ito K, Lim S, Caramori G, Cosio B, Chung KF, Adcock IM, Barnes PJ: A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. Epub 2002 Jun 17. - Pubmed
DTHybrid score 0.3231

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Brosen K: Drug interactions and the cytochrome P450 system. The role of cytochrome P450 1A2. Clin Pharmacokinet. 1995;29 Suppl 1:20-5. - Pubmed
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Sarkar MA, Hunt C, Guzelian PS, Karnes HT: Characterization of human liver cytochromes P-450 involved in theophylline metabolism. Drug Metab Dispos. 1992 Jan-Feb;20(1):31-7. - Pubmed
DTHybrid score 0.4001

Transporters


Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions inhibitor
References
  • Kobayashi Y, Sakai R, Ohshiro N, Ohbayashi M, Kohyama N, Yamamoto T: Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22. Epub 2005 Feb 11. - Pubmed
DTHybrid score 0.2148

Predictions


Id Partner name Gene Name Score
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.3361
268 Adenosine A2b receptor ADORA2B 0.2529
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.2046
4512 Cytochrome P450 3A4 CYP3A4 0.1627
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.1608
390 Adenosine A3 receptor ADORA3 0.1379
6013 Cytochrome P450 2E1 CYP2E1 0.1231
4119 Cytochrome P450 2D6 CYP2D6 0.0969
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0943
4757 Cytochrome P450 2C9 CYP2C9 0.093
1588 Multidrug resistance protein 1 ABCB1 0.0761
3957 Adenosine deaminase ADA 0.0756
4924 Cytochrome P450 2C8 CYP2C8 0.0711
6024 Cytochrome P450 1A1 CYP1A1 0.0706
6016 Cytochrome P450 2C19 CYP2C19 0.0678
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0678
1830 5'-nucleotidase NT5E 0.0669
6142 Solute carrier family 22 member 8 SLC22A8 0.0648
4121 Histone deacetylase 1 HDAC1 0.0633
1729 Solute carrier family 22 member 6 SLC22A6 0.0627
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0622
4118 Cytochrome P450 3A5 CYP3A5 0.0597
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0561
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0556
4123 Histone deacetylase 3 HDAC3 0.0556
4124 Histone deacetylase 6 HDAC6 0.0535
6107 Cytochrome P450 3A7 CYP3A7 0.053
1898 Cytochrome P450 1B1 CYP1B1 0.0511
1024 Solute carrier family 22 member 11 SLC22A11 0.0503
4762 Acetoin utilization protein acuC1 0.0464
777 Tumor necrosis factor TNF 0.0448
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.041
6021 Adenosine kinase ADK 0.0377
6171 Solute carrier family 28 member 3 SLC28A3 0.037
2921 Histone deacetylase 8 HDAC8 0.0366
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0328
587 Serum albumin ALB 0.0313
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.03
6030 Cytochrome P450 2B6 CYP2B6 0.0296
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.029
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0287
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0262
36 Insulin receptor INSR 0.0258
2164 Multidrug resistance-associated protein 4 ABCC4 0.0254
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0251
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.024
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0236
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0233
6136 Multidrug resistance-associated protein 5 ABCC5 0.0227
5718 Cytochrome P450 2A6 CYP2A6 0.0224
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.022
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0219
20 Prostaglandin G/H synthase 1 PTGS1 0.0212
3811 Cytochrome P450 19A1 CYP19A1 0.0209
814 Ryanodine receptor 1 RYR1 0.0208
290 Prostaglandin G/H synthase 2 PTGS2 0.019
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0186
6145 Solute carrier family 22 member 1 SLC22A1 0.0183
862 Multidrug resistance-associated protein 1 ABCC1 0.0175
6044 Serum paraoxonase/lactonase 3 PON3 0.0174
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0171
492 Histamine H1 receptor HRH1 0.0162
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.016
6144 Solute carrier family 22 member 2 SLC22A2 0.0158
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0154
144 Hemoglobin subunit alpha HBA1 0.0146
527 Prostacyclin receptor PTGIR 0.0143
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.014
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.014
118 Organic cation/carnitine transporter 2 SLC22A5 0.0139
3923 Cholinesterase BCHE 0.0136
572 Integrin alpha-L ITGAL 0.0132
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0129
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0129
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.0128
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0128
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0122
6020 Aldehyde oxidase AOX1 0.0121
318 Alpha-2A adrenergic receptor ADRA2A 0.0116
474 Acetylcholinesterase ACHE 0.0115
3947 Xanthine dehydrogenase/oxidase XDH 0.0115
3941 Amine oxidase [flavin-containing] A MAOA 0.0114
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0113
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0112
502 5-hydroxytryptamine 2A receptor HTR2A 0.0107
22 30S ribosomal protein S4 rpsD 0.0104
6714 30S ribosomal protein S4 rpsD 0.0104
738 Monocarboxylate transporter 1 SLC16A1 0.0101
831 D(2) dopamine receptor DRD2 0.01
1792 Tissue-type plasminogen activator PLAT 0.01
140 30S ribosomal protein S9 rpsI 0.0098
6719 30S ribosomal protein S9 rpsI 0.0098
6725 30S ribosomal protein S9 rpsI 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0097
817 DNA topoisomerase 2-alpha TOP2A 0.0096
556 Alpha-1A adrenergic receptor ADRA1A 0.009
885 5-hydroxytryptamine 1B receptor HTR1B 0.009
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0089
23 D(1A) dopamine receptor DRD1 0.0089
6106 Cytochrome P450 2C18 CYP2C18 0.0088
776 Bile salt export pump ABCB11 0.0088
5353 Glutamate decarboxylase alpha gadA 0.0087
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0085
6141 Sodium/bile acid cotransporter SLC10A1 0.0085
833 Organic cation/carnitine transporter 1 SLC22A4 0.0084
818 50S ribosomal protein L10 rplJ 0.0083
824 Sodium-dependent serotonin transporter SLC6A4 0.0082
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0081
6031 Cytochrome P450 3A43 CYP3A43 0.008
590 5-hydroxytryptamine 2C receptor HTR2C 0.0079
725 5-hydroxytryptamine 1D receptor HTR1D 0.0077
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0076
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0074
159 Penicillin-binding protein 2B penA 0.0071
6121 Penicillin-binding protein 2B penA 0.0071
338 DNA polymerase UL30 0.0069
379 DNA polymerase UL54 0.0069
697 DNA polymerase ORF28 0.0069
2482 DNA polymerase 43 0.0069
4104 DNA polymerase BALF5 0.0069
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0069
1867 Major prion protein PRNP 0.0069
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0069
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0068
3939 Amine oxidase [flavin-containing] B MAOB 0.0067
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0067
193 Beta-1 adrenergic receptor ADRB1 0.0063
320 5-hydroxytryptamine 1A receptor HTR1A 0.0063
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0063
3685 Catabolite gene activator crp 0.0063
4655 Adenylate cyclase cyaC 0.0063
4759 Adenylate cyclase cyaB2 0.0063
509 Thymidine kinase TK 0.0063
570 Thymidine kinase TK 0.0063
2559 Thymidine kinase TK 0.0063
3430 Thymidine kinase tdk 0.0063
3518 Thymidine kinase TK 0.0063
5301 Thymidine kinase tdk 0.0063
5771 Thymidine kinase ORF36 0.0063
7009 Thymidine kinase ORF36 0.0063
4238 50S ribosomal protein L4 rplD 0.0063
5578 50S ribosomal protein L4 rplD 0.0063
6173 50S ribosomal protein L4 rplD 0.0063
6219 50S ribosomal protein L4 rplD 0.0063
273 Apoptosis regulator Bcl-2 BCL2 0.0063
629 Alpha-2B adrenergic receptor ADRA2B 0.0062
632 Alpha-1B adrenergic receptor ADRA1B 0.0062
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0061
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
6149 Solute carrier family 22 member 10 SLC22A10 0.006
341 5-hydroxytryptamine 3 receptor HTR3A 0.006
6207 30S ribosomal protein S14 rpsN 0.0059
6209 30S ribosomal protein S19 rpsS 0.0059
6712 30S ribosomal protein S19 rpsS 0.0059
6726 30S ribosomal protein S19 rpsS 0.0059
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0058
4237 50S ribosomal protein L22 rplV 0.0058
6147 Solute carrier family 22 member 3 SLC22A3 0.0056
6148 Multidrug resistance-associated protein 7 ABCC10 0.0056
2249 Aspartate aminotransferase aspC 0.0054
2671 Aspartate aminotransferase aspC 0.0054
5490 Aspartate aminotransferase Not Available 0.0054
4760 Mll3241 protein mll3241 0.0054
638 D(3) dopamine receptor DRD3 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
713 Sodium-dependent dopamine transporter SLC6A3 0.0052
6014 Cytochrome P450 2A13 CYP2A13 0.0051
789 Alpha-1D adrenergic receptor ADRA1D 0.0051
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0051
6033 High affinity interleukin-8 receptor A CXCR1 0.0051
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0051
378 Alpha-2C adrenergic receptor ADRA2C 0.005
136 Estrogen receptor ESR1 0.0049
672 Prostaglandin F2-alpha receptor PTGFR 0.0049
766 Beta-2 adrenergic receptor ADRB2 0.0047
468 Cytochrome P450 4A11 CYP4A11 0.0046
867 Penicillin-binding protein 3 pbpC 0.0046
6119 Penicillin-binding protein 3 pbp3 0.0046
7154 Penicillin-binding protein 3 pbp3 0.0046
7157 Penicillin-binding protein 3 LMHCC_2184 0.0046
7162 Penicillin-binding protein 3 pbpB 0.0046
7172 Penicillin-binding protein 3 pbp3 0.0046
1654 Interleukin-1 beta IL1B 0.0045
275 Arachidonate 5-lipoxygenase ALOX5 0.0045
465 Calmodulin CALM1 0.0045
6220 Aryl hydrocarbon receptor AHR 0.0045
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0044
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0044
3917 Methylenetetrahydrofolate reductase MTHFR 0.0043
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0043
244 Angiotensin-converting enzyme ACE 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
663 Solute carrier family 12 member 4 SLC12A4 0.0042
53 Solute carrier family 12 member 5 SLC12A5 0.0042
183 Vascular endothelial growth factor A VEGFA 0.0042
4226 Uridine phosphorylase 2 UPP2 0.0041
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0041
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0041
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.004
103 Muscarinic acetylcholine receptor M1 CHRM1 0.004
432 D(4) dopamine receptor DRD4 0.004
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0039
310 Solute carrier family 12 member 2 SLC12A2 0.0039
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
4773 Deoxycytidine kinase DCK 0.0038
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0038
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0037
4225 Uridine phosphorylase 1 UPP1 0.0037
6137 Multidrug resistance-associated protein 6 ABCC6 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
284 DNA-directed RNA polymerase beta chain rpoB 0.0036
5773 DNA-directed RNA polymerase beta chain rpoB 0.0036
494 Caspase-1 CASP1 0.0036
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0036
413 Amidophosphoribosyltransferase PPAT 0.0035
2515 Amidophosphoribosyltransferase purF 0.0035
3714 Amidophosphoribosyltransferase purF 0.0035
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
24 Thymidylate synthase TMP1 0.0034
359 Thymidylate synthase TYMS 0.0034
2626 Thymidylate synthase thyA 0.0034
2729 Thymidylate synthase thyA 0.0034
5352 Thymidylate synthase THYA 0.0034
1507 Cytochrome c CYCS 0.0034
1757 Myeloperoxidase MPO 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
4217 Telomerase reverse transcriptase TERT 0.0034
712 Tubulin alpha chain TUB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
124 Histamine H2 receptor HRH2 0.0033
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0033
3760 Penicillin-binding protein 5 precursor dacA 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
5924 Microtubule-associated protein 4 MAP4 0.0032
5923 Microtubule-associated protein tau MAPT 0.0032
4604 Liver carboxylesterase 1 CES1 0.0032
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0031
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0031
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0031
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
2077 Caspase-3 CASP3 0.003
558 Solute carrier family 12 member 1 SLC12A1 0.003
173 Toll-like receptor 7 TLR7 0.003
65 Matrix metalloproteinase-9 Not Available 0.003
1852 Microtubule-associated protein 2 MAP2 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
819 Penicillin-binding protein 4 dacB 0.0029
6043 Putative G-protein coupled receptor 44 GPR44 0.0029
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0029
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0029
3639 Thymidine phosphorylase deoA 0.0029
3936 Thymidine phosphorylase TYMP 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0028
1039 Histone deacetylase 9 HDAC9 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
115 Penicillin-binding protein 2 mrdA 0.0027
6069 Penicillin-binding protein 2 mrdA 0.0027
6118 Penicillin-binding protein 2 penA 0.0027
6187 Penicillin-binding protein 2 pbpA 0.0027
6686 Penicillin-binding protein 2 pbp2 0.0027
6939 Penicillin-binding protein 2 mrdA 0.0027
7163 Penicillin-binding protein 2 pbpA 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
756 Sex hormone-binding globulin SHBG 0.0027
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0026
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0026
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
2320 Thymidine kinase, cytosolic TK1 0.0026
543 Penicillin-binding protein 1B mrcB 0.0026
6186 Penicillin-binding protein 1B ponB 0.0026
6822 Penicillin-binding protein 1b pbp1b 0.0026
6844 Penicillin-binding protein 1b pbp1b 0.0026
1 Peptidoglycan synthetase ftsI ftsI 0.0025
4155 Peptidoglycan synthetase ftsI ftsI 0.0025
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0025
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
29 Tubulin beta-1 chain TUBB1 0.0025
645 Penicillin-binding protein 1A mrcA 0.0025
5805 Penicillin-binding protein 1A ponA 0.0025
6185 Penicillin-binding protein 1A mrcA 0.0025
6799 Penicillin-binding protein 1A pbpA 0.0025
5880 Thrombopoietin receptor MPL 0.0025
1517 Beta-3 adrenergic receptor ADRB3 0.0024
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0024
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0024
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0024
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0024
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0024
6070 Nischarin NISCH 0.0024
633 Penicillin-binding proteins 1A/1B pbpA 0.0023
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0023
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0023
6218 Pannexin-1 PANX1 0.0022
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0022
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
332 Beta-lactamase blaZ 0.0021
2478 Beta-lactamase ampC 0.0021
2613 Beta-lactamase ampC 0.0021
2635 Beta-lactamase ampC 0.0021
2700 Beta-lactamase penP 0.0021
5445 Beta-lactamase blaB 0.0021
6019 Beta-lactamase SHV-7 0.0021
6701 Beta-lactamase cphA 0.0021
731 HIV-1 protease HIV-1 protease 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
260 Cytochrome P450 51 ERG11 0.0021
761 Cytochrome P450 51 ERG11 0.0021
3163 Cytochrome P450 51 cyp51 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0021
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0021
869 Estrogen receptor beta ESR2 0.0021
871 Glucocorticoid receptor NR3C1 0.0021
5818 Folate receptor alpha FOLR1 0.002
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.002
1820 Beta-nerve growth factor NGF 0.002
6042 Prostaglandin reductase 2 PTGR2 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.002
228 Beta platelet-derived growth factor receptor PDGFRB 0.0019
365 Dihydrofolate reductase DHFR 0.0019
2381 Dihydrofolate reductase DFR1 0.0019
2833 Dihydrofolate reductase Not Available 0.0019
2931 Dihydrofolate reductase folA 0.0019
3544 Dihydrofolate reductase folA 0.0019
3682 Dihydrofolate reductase folA 0.0019
6642 Dihydrofolate reductase folA 0.0019
6756 Dihydrofolate reductase dfrA 0.0019
716 5-hydroxytryptamine 7 receptor HTR7 0.0019
146 Androgen receptor AR 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
504 Mast/stem cell growth factor receptor KIT 0.0018
293 Gamma-glutamyl hydrolase GGH 0.0018
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1648 Elastin ELN 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0017
1656 CYP2B protein CYP2B 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
1243 Cathepsin D CTSD 0.0016
1010 Cytochrome P450 51A1 CYP51A1 0.0016
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0016
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0016
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0016
6493 Cytochrome c oxidase subunit 6C COX6C 0.0016
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0016
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0016
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0016
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0016
373 Transthyretin TTR 0.0016
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0016
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0016
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0016
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0016
6558 Cytochrome c oxidase subunit 1 ctaD 0.0016
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0016
6559 Cytochrome c oxidase subunit 2 ctaC 0.0016
6669 Cytochrome c oxidase subunit 2 ctaC 0.0016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0016
427 Substance-P receptor TACR1 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
1650 Heme carrier protein 1 SLC46A1 0.0015
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0015
921 Glutamate receptor 2 GRIA2 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
517 Alcohol dehydrogenase 1C ADH1C 0.0015
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0015
1313 Lactoylglutathione lyase GLO1 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6432 Transporter snf 0.0015
3587 Gastrotropin FABP6 0.0015
2540 Choloylglycine hydrolase cbh 0.0014
489 Monocarboxylate transporter 2 SLC16A7 0.0014
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
6501 Fatty acid-binding protein, liver FABP1 0.0014
847 Mu-type opioid receptor OPRM1 0.0014
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0014
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
380 Cytochrome P450 17A1 CYP17A1 0.0013
844 Epidermal growth factor receptor EGFR 0.0013
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0013
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0013
696 Kappa-type opioid receptor OPRK1 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
3809 Estrogen-related receptor gamma ESRRG 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0012
518 Peroxidase/catalase T katG 0.0012
1629 Transcription factor AP-1 JUN 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
6500 Phospholipase A2 PLA2G1B 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
563 Thyroid peroxidase TPO 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
467 Delta-type opioid receptor OPRD1 0.0011
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
239 Coagulation factor X F10 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
823 Fibroblast growth factor receptor 2 FGFR2 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6182 Cytochrome P450 2J2 CYP2J2 0.0009
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
229 Retinoic acid receptor beta RARB 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0009
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0009
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
528 5-hydroxytryptamine 1E receptor HTR1E 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
3830 Calreticulin CALR 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0008
1618 High affinity nerve growth factor receptor NTRK1 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
811 Translocator protein TSPO 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
976 Platelet glycoprotein IX GP9 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
3810 Catechol O-methyltransferase COMT 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
822 Aldose reductase AKR1B1 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1864 RET proto-oncogene RET 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
798 Osteocalcin BGLAP 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0005
4120 NADPH--cytochrome P450 reductase POR 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
369 Coagulation factor VII F7 0.0005
896 Glutathione S-transferase Mu 1 GSTM1 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
172 Potassium channel subfamily K member 1 KCNK1 0.0005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
165 FL cytokine receptor FLT3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0004
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
295 Carbonic anhydrase 1 CA1 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
614 Progesterone receptor PGR 0.0003
6085 Fatty acid-binding protein, intestinal FABP2 0.0003
164 Histamine H4 receptor HRH4 0.0003
54 Prothrombin F2 0.0003
7 Nitric oxide synthase, inducible NOS2 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0002
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