DT-Web

DB00787 - Acyclovir


Identification
Name Acyclovir
Accession Number DB00787 (APRD00567, EXPT00406)
Type small molecule
Description A guanosine analog antiviral drug that acts as an antimetabolite. Acyclovir is used for the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 225.2046
Groups approved
Monoisotopic Weight 225.086189243
Pharmacology
Indication For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.
Mechanism of action Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts aciclovir to the aciclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator. One may consider aciclovir to be a prodrug as it is metabolized to more active compounds. Aciclovir is selective and low in cytotoxicity as the cellular thymidine kinase of normal, uninfected cells does not use aciclovir effectively as a substrate.
Absorption The oral bioavailability is 10% to 20%, and decreases with increasing dose. Food does not affect the absorption of acyclovir. The following are the pharmacokinetic parameters for 50 mg buccal tablet, Sitavig, in the saliva: AUC 0 - 24 hours = 2900?2400 mcg.h/mL; Cmax = 440?241 mcg/mL; Tmax = 7.95 ? 4.08 hours.
Protein binding 9%-33%
Biotransformation Hepatic, Acyclovir is metabolized to 9-[(carboxymethoxy)methyl]guanine (CMMG) and 8- hydroxy-acyclovir (8-OH-ACV) by oxidation and hydroxylation. It is suggested in studies that acyclovir is first metabolized to acyclovir aldehyde by alcohol dehydrogenase and then converted to CMMG. The build up of acyclovir aldehyde may be the cause of acyclovir-induced nephrotoxicity in the absence of crystalluria.
Route of elimination Primarily excreted unchanged by the kidneys via active tubular secretion.
Toxicity Aciclovir may cause nephrotoxicity (crystallization of aciclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of aciclovir therapy. However, there is no well-defined relationship between aciclovir concentrations in the blood and these adverse effects.
Affected organisms
  • Human Herpes Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Aminophylline Acyclovir increases the effect and toxicity of theophylline
Dyphylline Acyclovir increases the effect and toxicity of dyphylline.
Oxtriphylline Aciclovir may increase the effect and toxicity of oxtriphylline.
Theophylline Acyclovir may increase the effect and toxicity of theophylline.
Food Interactions
  • Take without regard to meals.
  • Increase liquid intake.

Targets


Thymidine kinase
Name Thymidine kinase
Gene Name TK
Pharmacological action yes
Actions potentiator
References
  • Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR: Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir. FEBS Lett. 1999 Jan 25;443(2):121-5. - Pubmed
DTHybrid score 0.0582
DNA polymerase
Name DNA polymerase
Gene Name UL30
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sergerie Y, Boivin G: Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes. Antiviral Res. 2007 Sep 17;. - Pubmed
  • Suzuki M, Okuda T, Shiraki K: Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. Epub 2006 May 30. - Pubmed
  • Liu S, Knafels JD, Chang JS, Waszak GA, Baldwin ET, Deibel MR Jr, Thomsen DR, Homa FL, Wells PA, Tory MC, Poorman RA, Gao H, Qiu X, Seddon AP: Crystal structure of the herpes simplex virus 1 DNA polymerase. J Biol Chem. 2006 Jun 30;281(26):18193-200. Epub 2006 Apr 24. - Pubmed
DTHybrid score 0.7045
DNA polymerase
Name DNA polymerase
Gene Name ORF28
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sergerie Y, Boivin G: Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes. Antiviral Res. 2007 Sep 17;. - Pubmed
  • Suzuki M, Okuda T, Shiraki K: Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72(2):157-61. Epub 2006 May 30. - Pubmed
  • Liu S, Knafels JD, Chang JS, Waszak GA, Baldwin ET, Deibel MR Jr, Thomsen DR, Homa FL, Wells PA, Tory MC, Poorman RA, Gao H, Qiu X, Seddon AP: Crystal structure of the herpes simplex virus 1 DNA polymerase. J Biol Chem. 2006 Jun 30;281(26):18193-200. Epub 2006 Apr 24. - Pubmed
DTHybrid score 0.7045

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
DTHybrid score 0.3467
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions substrate,inhibitor
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
  • Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H: Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. - Pubmed
DTHybrid score 0.5077
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions substrate,inhibitor
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
  • Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T: Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002 Oct;83(1):57-66. - Pubmed
  • Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed
DTHybrid score 0.3842
Ileal sodium/bile acid cotransporter
Name Ileal sodium/bile acid cotransporter
Gene Name SLC10A2
Actions substrate
References
  • Tolle-Sander S, Lentz KA, Maeda DY, Coop A, Polli JE: Increased acyclovir oral bioavailability via a bile acid conjugate. Mol Pharm. 2004 Jan 12;1(1):40-8. - Pubmed
DTHybrid score 0.3378
Multidrug and toxin extrusion protein 1
Name Multidrug and toxin extrusion protein 1
Gene Name SLC47A1
Actions substrate
References
  • Nies AT, Damme K, Schaeffeler E, Schwab M: Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs. Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1565-77. doi: 10.1517/17425255.2012.722996. Epub 2012 Sep 13. - Pubmed
DTHybrid score 0.347
Multidrug and toxin extrusion protein 2
Name Multidrug and toxin extrusion protein 2
Gene Name Not Available
Actions substrate
References
  • Nies AT, Damme K, Schaeffeler E, Schwab M: Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs. Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1565-77. doi: 10.1517/17425255.2012.722996. Epub 2012 Sep 13. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
379 DNA polymerase UL54 0.7045
2482 DNA polymerase 43 0.7045
4104 DNA polymerase BALF5 0.7045
6020 Aldehyde oxidase AOX1 0.1447
4512 Cytochrome P450 3A4 CYP3A4 0.1379
6143 Solute carrier family 22 member 7 SLC22A7 0.1156
1024 Solute carrier family 22 member 11 SLC22A11 0.109
6144 Solute carrier family 22 member 2 SLC22A2 0.1087
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1083
6141 Sodium/bile acid cotransporter SLC10A1 0.1073
776 Bile salt export pump ABCB11 0.0991
118 Organic cation/carnitine transporter 2 SLC22A5 0.0747
1588 Multidrug resistance protein 1 ABCB1 0.0738
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0735
6147 Solute carrier family 22 member 3 SLC22A3 0.0708
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0689
587 Serum albumin ALB 0.0673
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0615
509 Thymidine kinase TK 0.0582
570 Thymidine kinase TK 0.0582
3430 Thymidine kinase tdk 0.0582
3518 Thymidine kinase TK 0.0582
5301 Thymidine kinase tdk 0.0582
5771 Thymidine kinase ORF36 0.0582
7009 Thymidine kinase ORF36 0.0582
738 Monocarboxylate transporter 1 SLC16A1 0.0575
2251 Thymidylate kinase tmk 0.0567
2254 Thymidylate kinase DTYMK 0.0567
3522 Thymidylate kinase tmk 0.0567
2164 Multidrug resistance-associated protein 4 ABCC4 0.0565
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0541
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0525
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0517
4119 Cytochrome P450 2D6 CYP2D6 0.0506
4757 Cytochrome P450 2C9 CYP2C9 0.05
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0486
492 Histamine H1 receptor HRH1 0.0456
833 Organic cation/carnitine transporter 1 SLC22A4 0.044
4118 Cytochrome P450 3A5 CYP3A5 0.0425
4200 Cytochrome P450 1A2 CYP1A2 0.0409
6016 Cytochrome P450 2C19 CYP2C19 0.0407
20 Prostaglandin G/H synthase 1 PTGS1 0.0392
290 Prostaglandin G/H synthase 2 PTGS2 0.0382
6107 Cytochrome P450 3A7 CYP3A7 0.0365
862 Multidrug resistance-associated protein 1 ABCC1 0.0358
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0346
4924 Cytochrome P450 2C8 CYP2C8 0.0338
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.032
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0317
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0291
6013 Cytochrome P450 2E1 CYP2E1 0.026
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0251
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0249
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0247
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0244
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0236
6148 Multidrug resistance-associated protein 7 ABCC10 0.0226
4148 Serine/threonine-protein kinase mTOR MTOR 0.0221
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.021
124 Histamine H2 receptor HRH2 0.0207
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0207
6171 Solute carrier family 28 member 3 SLC28A3 0.0205
2016 Dipeptidase 1 DPEP1 0.0197
633 Penicillin-binding proteins 1A/1B pbpA 0.0195
1525 Heparin-binding growth factor 2 FGF2 0.0192
3587 Gastrotropin FABP6 0.0188
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0186
645 Penicillin-binding protein 1A mrcA 0.0185
5805 Penicillin-binding protein 1A ponA 0.0185
6185 Penicillin-binding protein 1A mrcA 0.0185
6799 Penicillin-binding protein 1A pbpA 0.0185
6024 Cytochrome P450 1A1 CYP1A1 0.0179
2257 Uridine phosphorylase udp 0.0177
5132 Uridine phosphorylase udp 0.0177
4275 PCZA361.16 Not Available 0.0175
4276 DNA polymerase III subunit epsilon dnaQ 0.0174
22 30S ribosomal protein S4 rpsD 0.0173
6714 30S ribosomal protein S4 rpsD 0.0173
140 30S ribosomal protein S9 rpsI 0.0163
6719 30S ribosomal protein S9 rpsI 0.0163
6725 30S ribosomal protein S9 rpsI 0.0163
543 Penicillin-binding protein 1B mrcB 0.0162
6186 Penicillin-binding protein 1B ponB 0.0162
6822 Penicillin-binding protein 1b pbp1b 0.0162
6844 Penicillin-binding protein 1b pbp1b 0.0162
6136 Multidrug resistance-associated protein 5 ABCC5 0.0162
768 FK506-binding protein 1A FKBP1A 0.0162
6167 Organic solute transporter subunit beta OSTB 0.016
6166 Organic solute transporter subunit alpha OSTA 0.016
1353 DNA topoisomerase 1 TOP1 0.0157
3552 DNA topoisomerase 1 topA 0.0157
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
24 Thymidylate synthase TMP1 0.0145
359 Thymidylate synthase TYMS 0.0145
2626 Thymidylate synthase thyA 0.0145
2729 Thymidylate synthase thyA 0.0145
5352 Thymidylate synthase THYA 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
5626 Nucleoside diphosphate kinase B NME2 0.0144
592 Carbonic anhydrase 4 CA4 0.0141
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
672 Prostaglandin F2-alpha receptor PTGFR 0.0139
295 Carbonic anhydrase 1 CA1 0.0133
357 Carbonic anhydrase 2 CA2 0.0131
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0128
831 D(2) dopamine receptor DRD2 0.0128
5294 Nucleoside diphosphate kinase A NME1 0.0127
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
438 Taste receptor type 1 member 2 TAS1R2 0.0122
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0117
23 D(1A) dopamine receptor DRD1 0.0116
502 5-hydroxytryptamine 2A receptor HTR2A 0.0111
3686 Acyl-CoA thioesterase I precursor tesA 0.0111
6030 Cytochrome P450 2B6 CYP2B6 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0108
556 Alpha-1A adrenergic receptor ADRA1A 0.0108
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0107
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0107
3947 Xanthine dehydrogenase/oxidase XDH 0.0107
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0101
887 DNA gyrase subunit B gyrB 0.0099
4150 DNA gyrase subunit B gyrB 0.0099
6225 DNA gyrase subunit B gyrB 0.0099
558 Solute carrier family 12 member 1 SLC12A1 0.0098
4604 Liver carboxylesterase 1 CES1 0.0095
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0095
6106 Cytochrome P450 2C18 CYP2C18 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
632 Alpha-1B adrenergic receptor ADRA1B 0.0092
2391 Ferrochelatase hemH 0.0092
6502 Ferrochelatase DKFZp686P18130 0.0092
1591 Ferrochelatase, mitochondrial FECH 0.0092
4773 Deoxycytidine kinase DCK 0.0091
5353 Glutamate decarboxylase alpha gadA 0.0091
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0088
6149 Solute carrier family 22 member 10 SLC22A10 0.0087
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0087
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0087
756 Sex hormone-binding globulin SHBG 0.0086
474 Acetylcholinesterase ACHE 0.0086
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0085
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0084
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0084
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0083
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0083
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0083
341 5-hydroxytryptamine 3 receptor HTR3A 0.0083
33 Cystine/glutamate transporter SLC7A11 0.0082
320 5-hydroxytryptamine 1A receptor HTR1A 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
766 Beta-2 adrenergic receptor ADRB2 0.0081
378 Alpha-2C adrenergic receptor ADRA2C 0.008
332 Beta-lactamase blaZ 0.0079
2478 Beta-lactamase ampC 0.0079
2613 Beta-lactamase ampC 0.0079
2635 Beta-lactamase ampC 0.0079
2700 Beta-lactamase penP 0.0079
5445 Beta-lactamase blaB 0.0079
6019 Beta-lactamase SHV-7 0.0079
6701 Beta-lactamase cphA 0.0079
6493 Cytochrome c oxidase subunit 6C COX6C 0.0078
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0078
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0078
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0078
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0078
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0078
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0078
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0078
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0078
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0078
6559 Cytochrome c oxidase subunit 2 ctaC 0.0078
6669 Cytochrome c oxidase subunit 2 ctaC 0.0078
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0078
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0078
6558 Cytochrome c oxidase subunit 1 ctaD 0.0078
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
115 Penicillin-binding protein 2 mrdA 0.0076
6069 Penicillin-binding protein 2 mrdA 0.0076
6118 Penicillin-binding protein 2 penA 0.0076
6187 Penicillin-binding protein 2 pbpA 0.0076
6686 Penicillin-binding protein 2 pbp2 0.0076
6939 Penicillin-binding protein 2 mrdA 0.0076
7163 Penicillin-binding protein 2 pbpA 0.0076
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0076
5718 Cytochrome P450 2A6 CYP2A6 0.0076
2472 Voltage-gated potassium channel kcsA 0.0075
6366 Voltage-gated potassium channel kcsA 0.0075
2320 Thymidine kinase, cytosolic TK1 0.0074
373 Transthyretin TTR 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
2540 Choloylglycine hydrolase cbh 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0069
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0069
629 Alpha-2B adrenergic receptor ADRA2B 0.0069
1867 Major prion protein PRNP 0.0067
6501 Fatty acid-binding protein, liver FABP1 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
193 Beta-1 adrenergic receptor ADRB1 0.0065
1757 Myeloperoxidase MPO 0.0065
3685 Catabolite gene activator crp 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
277 Purine nucleoside phosphorylase PNP 0.0064
2870 Purine nucleoside phosphorylase punA 0.0064
2945 Purine nucleoside phosphorylase punA 0.0064
4659 Purine nucleoside phosphorylase TM_1596 0.0064
4825 Purine nucleoside phosphorylase TTHA1435 0.0064
275 Arachidonate 5-lipoxygenase ALOX5 0.0064
3811 Cytochrome P450 19A1 CYP19A1 0.0064
3923 Cholinesterase BCHE 0.0063
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0062
318 Alpha-2A adrenergic receptor ADRA2A 0.0061
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0061
1405 Thiopurine S-methyltransferase TPMT 0.0061
130 Prostacyclin synthase PTGIS 0.0061
244 Angiotensin-converting enzyme ACE 0.0061
220 Sodium channel protein type 5 subunit alpha SCN5A 0.006
136 Estrogen receptor ESR1 0.006
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0059
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
6207 30S ribosomal protein S14 rpsN 0.0058
6209 30S ribosomal protein S19 rpsS 0.0058
6712 30S ribosomal protein S19 rpsS 0.0058
6726 30S ribosomal protein S19 rpsS 0.0058
5126 Arginase rocF 0.0057
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0056
2249 Aspartate aminotransferase aspC 0.0056
2671 Aspartate aminotransferase aspC 0.0056
5490 Aspartate aminotransferase Not Available 0.0056
3809 Estrogen-related receptor gamma ESRRG 0.0055
146 Androgen receptor AR 0.0055
4760 Mll3241 protein mll3241 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0055
6500 Phospholipase A2 PLA2G1B 0.0055
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
1898 Cytochrome P450 1B1 CYP1B1 0.0054
408 Riboflavin kinase RFK 0.0054
3917 Methylenetetrahydrofolate reductase MTHFR 0.0053
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
740 Argininosuccinate synthase ASS1 0.0052
865 Argininosuccinate synthase ASS1 0.0052
2680 Argininosuccinate synthase argG 0.0052
3194 Argininosuccinate synthase argG 0.0052
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0052
3941 Amine oxidase [flavin-containing] A MAOA 0.0051
65 Matrix metalloproteinase-9 Not Available 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0051
6033 High affinity interleukin-8 receptor A CXCR1 0.0051
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
1198 Serum paraoxonase/arylesterase 1 PON1 0.005
6223 Penicillin-binding protein 1C pbpC 0.005
527 Prostacyclin receptor PTGIR 0.005
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
6014 Cytochrome P450 2A13 CYP2A13 0.0049
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0048
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0048
789 Alpha-1D adrenergic receptor ADRA1D 0.0048
517 Alcohol dehydrogenase 1C ADH1C 0.0047
731 HIV-1 protease HIV-1 protease 0.0047
867 Penicillin-binding protein 3 pbpC 0.0046
6119 Penicillin-binding protein 3 pbp3 0.0046
7154 Penicillin-binding protein 3 pbp3 0.0046
7157 Penicillin-binding protein 3 LMHCC_2184 0.0046
7162 Penicillin-binding protein 3 pbpB 0.0046
7172 Penicillin-binding protein 3 pbp3 0.0046
624 Guanidinoacetate N-methyltransferase GAMT 0.0046
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0045
1654 Interleukin-1 beta IL1B 0.0045
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
817 DNA topoisomerase 2-alpha TOP2A 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
53 Solute carrier family 12 member 5 SLC12A5 0.0042
663 Solute carrier family 12 member 4 SLC12A4 0.0042
5682 Ribonuclease pancreatic RNASE1 0.0042
6070 Nischarin NISCH 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
702 UMP-CMP kinase CMPK1 0.004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.004
540 Sodium-dependent noradrenaline transporter SLC6A2 0.004
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0039
3939 Amine oxidase [flavin-containing] B MAOB 0.0039
310 Solute carrier family 12 member 2 SLC12A2 0.0039
694 Matrix protein 2 M 0.0039
6043 Putative G-protein coupled receptor 44 GPR44 0.0039
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0039
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0039
5482 Sialidase-2 NEU2 0.0039
869 Estrogen receptor beta ESR2 0.0037
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0037
494 Caspase-1 CASP1 0.0037
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0037
183 Vascular endothelial growth factor A VEGFA 0.0036
6218 Pannexin-1 PANX1 0.0036
293 Gamma-glutamyl hydrolase GGH 0.0036
6137 Multidrug resistance-associated protein 6 ABCC6 0.0036
6131 Carbonic anhydrase 14 CA14 0.0035
1830 5'-nucleotidase NT5E 0.0035
1507 Cytochrome c CYCS 0.0035
6085 Fatty acid-binding protein, intestinal FABP2 0.0034
824 Sodium-dependent serotonin transporter SLC6A4 0.0034
125 DNA polymerase beta POLB 0.0034
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
3760 Penicillin-binding protein 5 precursor dacA 0.0033
4217 Telomerase reverse transcriptase TERT 0.0033
2300 Lysozyme E 0.0033
3633 Lysozyme R 0.0033
5597 Lysozyme 17 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
6031 Cytochrome P450 3A43 CYP3A43 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0032
1650 Heme carrier protein 1 SLC46A1 0.0032
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0032
828 Phenylalanine-4-hydroxylase PAH 0.0032
3109 Phenylalanine-4-hydroxylase phhA 0.0032
758 Thyroid hormone receptor alpha THRA 0.0031
449 Ornithine decarboxylase ODC1 0.0031
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0031
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0031
2077 Caspase-3 CASP3 0.0031
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0031
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0031
465 Calmodulin CALM1 0.0031
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0031
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
819 Penicillin-binding protein 4 dacB 0.003
654 Flavin reductase BLVRB 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
713 Sodium-dependent dopamine transporter SLC6A3 0.0029
4252 Penicillin-binding protein 5 dacA 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0028
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0028
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0028
380 Cytochrome P450 17A1 CYP17A1 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
1341 Histamine H3 receptor HRH3 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0027
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0027
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
2021 Thrombomodulin THBD 0.0027
1025 Aquaporin-1 AQP1 0.0027
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0026
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0026
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0026
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
164 Histamine H4 receptor HRH4 0.0026
751 Potassium channel subfamily K member 6 KCNK6 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0026
3810 Catechol O-methyltransferase COMT 0.0026
707 72 kDa type IV collagenase MMP2 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
163 D(1B) dopamine receptor DRD5 0.0024
172 Potassium channel subfamily K member 1 KCNK1 0.0024
489 Monocarboxylate transporter 2 SLC16A7 0.0023
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
432 D(4) dopamine receptor DRD4 0.0023
1039 Histone deacetylase 9 HDAC9 0.0023
638 D(3) dopamine receptor DRD3 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
6168 Solute carrier family 22 member 16 SLC22A16 0.0021
6151 Monocarboxylate transporter 10 SLC16A10 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0021
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
976 Platelet glycoprotein IX GP9 0.0021
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.002
5818 Folate receptor alpha FOLR1 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
504 Mast/stem cell growth factor receptor KIT 0.002
6042 Prostaglandin reductase 2 PTGR2 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
6432 Transporter snf 0.0019
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
1792 Tissue-type plasminogen activator PLAT 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
5287 Signaling protein Not Available 0.0018
2874 Nitrogenase iron protein 1 nifH1 0.0018
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0018
5292 Putative partitioning protein TT_C1605 0.0018
5293 Shikimate kinase 2 aroL 0.0018
5288 Shikimate kinase aroK 0.0018
5304 UPF0166 protein TM_0021 TM_0021 0.0018
5266 Activator of hgdC 0.0018
3199 Phosphopantetheine adenylyltransferase coaD 0.0018
3543 Phosphopantetheine adenylyltransferase coaD 0.0018
3567 Phosphopantetheine adenylyltransferase coaD 0.0018
5289 Phosphopantetheine adenylyltransferase coaD 0.0018
4346 Polynucleotide kinase pseT 0.0018
5283 D-alanine--D-alanine ligase B ddlB 0.0018
5291 Glycogen synthase 1 glgA1 0.0018
5281 Plasmid segregation protein parM parM 0.0018
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0018
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0018
5299 D-alanine--D-alanine ligase ddl 0.0018
6598 D-alanine--D-alanine ligase ddl 0.0018
5276 Chromosomal replication initiator protein dnaA dnaA 0.0018
5259 Transcriptional regulator ntrC1 0.0018
6699 Transcriptional regulator Cgl2612 0.0018
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0018
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0018
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0018
5264 DNA replication protein REP 0.0018
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0018
5315 Chaperone protein htpG htpG 0.0018
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0018
5284 Large T antigen Not Available 0.0018
5308 Preprotein translocase secA 1 subunit secA1 0.0018
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0018
5285 Kinesin heavy chain KIF5B 0.0018
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0018
5261 Phosphoribosylformylglycinamidine synthase purL 0.0018
5277 Preprotein translocase subunit secA secA 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
847 Mu-type opioid receptor OPRM1 0.0018
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
3924 Phospholipase D1 PLD1 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
4106 Guanylate kinase GUK1 0.0016
4516 Guanylate kinase gmk 0.0016
413 Amidophosphoribosyltransferase PPAT 0.0016
2515 Amidophosphoribosyltransferase purF 0.0016
3714 Amidophosphoribosyltransferase purF 0.0016
4837 Cag-alfa cag-alfa 0.0016
5646 Galactokinase GALK1 0.0016
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0016
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0016
5302 TrwB trwB 0.0016
4774 NTPase P4 Not Available 0.0016
5265 FtsH ftsH 0.0016
4839 DNA polymerase III subunit tau dnaX 0.0016
4838 PMS1 protein homolog 2 PMS2 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
2270 Dephospho-CoA kinase coaE 0.0016
5189 Trimethylamine dehydrogenase tmd 0.0016
6277 Heat shock cognate 71 kDa protein HSPA8 0.0016
2284 Adenylate kinase adk 0.0016
2296 Adenylate kinase adk 0.0016
2311 Adenylate kinase adk 0.0016
2312 Adenylate kinase Not Available 0.0016
3470 Hypothetical protein MG245 homolog MPN_348 0.0015
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0015
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0015
1313 Lactoylglutathione lyase GLO1 0.0015
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
3175 Glutamate--cysteine ligase gshA 0.0015
3426 Glutamine synthetase glnA 0.0015
3987 Glutamine synthetase GLUL 0.0015
1864 RET proto-oncogene RET 0.0015
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0015
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
6146 High affinity copper uptake protein 1 SLC31A1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
2683 Mono-ADP-ribosyltransferase C3 C3 0.0014
2390 Nonsecretory ribonuclease RNASE2 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
5312 Kinesin-like protein KIF1A KIF1A 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
908 Glutathione S-transferase theta-1 GSTT1 0.0014
2922 Glycerol kinase glpK 0.0014
5271 Focal adhesion kinase 1 PTK2 0.0014
6645 D-amino-acid oxidase DAO 0.0014
340 Apoptotic protease-activating factor 1 APAF1 0.0014
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0014
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0014
822 Aldose reductase AKR1B1 0.0014
2615 Chemotaxis protein cheA cheA 0.0013
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
2282 Protein recA recA 0.0013
2315 Protein recA recA 0.0013
2332 Protein recA recA 0.0013
5263 Protein recA recA 0.0013
2371 Pantothenate kinase coaA 0.0013
1881 Hexokinase-1 HK1 0.0013
3669 Ribokinase rbsK 0.0013
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0013
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0013
2892 Acetylglutamate kinase argB 0.0013
3550 Acetylglutamate kinase argB 0.0013
5300 Antigen peptide transporter 1 TAP1 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0013
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0013
1360 Sphingomyelin phosphodiesterase SMPD1 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
2727 S-adenosylmethionine synthetase metK 0.0013
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0012
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0012
2697 Uridine-cytidine kinase 2 UCK2 0.0012
725 5-hydroxytryptamine 1D receptor HTR1D 0.0012
788 Creatine kinase M-type CKM 0.0012
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0012
2334 Dethiobiotin synthetase bioD 0.0012
6555 Dethiobiotin synthetase bioD 0.0012
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
885 5-hydroxytryptamine 1B receptor HTR1B 0.0012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0012
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0012
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0012
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0011
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0011
904 Glutathione S-transferase P GSTP1 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
48 Pyridoxal kinase PDXK 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0011
6395 Myosin-14 MYH14 0.0011
2091 Endoplasmin HSP90B1 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
365 Dihydrofolate reductase DHFR 0.0011
2381 Dihydrofolate reductase DFR1 0.0011
2833 Dihydrofolate reductase Not Available 0.0011
2931 Dihydrofolate reductase folA 0.0011
3544 Dihydrofolate reductase folA 0.0011
3682 Dihydrofolate reductase folA 0.0011
6642 Dihydrofolate reductase folA 0.0011
6756 Dihydrofolate reductase dfrA 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
1422 Serine/threonine-protein kinase 6 AURKA 0.0011
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
3379 Kinesin-like protein KIF11 KIF11 0.001
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
737 Mineralocorticoid receptor NR3C2 0.001
3456 Heat shock protein HSP 90-beta HSP90AB1 0.001
997 Protein kinase C beta type PRKCB 0.001
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3822 Actin, alpha skeletal muscle ACTA1 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
614 Progesterone receptor PGR 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
1721 Glycogen synthase kinase-3 beta GSK3B 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0009
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0009
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0008
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0008
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0007
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0007
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0007
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0007
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0007
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0007
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0007
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0007
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0007
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0007
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0007
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0006
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0006
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0005
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