Partner ID 749
Name Amiloride-sensitive cation channel 1, neuronal
Synonyms 2196
Gene name ACCN1
General function Involved in amiloride-sensitive sodium channel activity
Specific function Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate
Gene sequence + ...

ATGGACCTCAAGGAAAGCCCCAGTGAGGGCAGCCTGCAACCTTCTAGCATCCAGATCTTTGCCAACACCTCCACCCTCCATGGCATCCGCCACATCTTCGTGTATGGGCCGCTGACCATCCGGCGTGTGCTGTGGGCAGTGGCCTTCGTGGGCTCTCTGGGCCTGCTGCTGGTGGAGAGCTCTGAGAGGGTGTCCTACTACTTCTCCTACCAGCATGTCACTAAGGTGGACGAAGTGGTGGCTCAAAGCCTGGTCTTCCCAGCTGTGACCCTCTGTAACCTCAATGGCTTCCGGTTCTCCAGGCTCACCACCAACGACCTGTACCATGCTGGGGAGCTGCTGGCCCTGCTGGATGTCAACCTGCAGATCCCGGACCCCCATCTGGCTGACCCCTCCGTGCTGGAGGCCCTGCGGCAGAAGGCCAACTTCAAGCACTACAAACCCAAGCAGTTCAGCATGCTGGAGTTCCTGCACCGTGTGGGCCATGACCTGAAGGATATGATGCTCTACTGCAAGTTCAAAGGGCAGGAGTGCGGCCACCAAGACTTCACCACAGTGTTTACAAAATATGGGAAGTGTTACATGTTTAACTCAGGCGAGGATGGCAAACCTCTGCTCACCACGGTCAAGGGGGGGACAGGCAACGGGCTGGAGATCATGCTGGACATTCAGCAGGATGAGTACCTGCCCATCTGGGGAGAGACAGAGGAAACGACATTTGAAGCAGGAGTGAAAGTTCAGATCCACAGTCAGTCTGAGCCACCTTTCATCCAAGAGCTGGGCTTTGGGGTGGCTCCAGGGTTCCAGACCTTTGTGGCCACACAGGAGCAGAGGCTCACATACCTGCCCCCACCGTGGGGTGAGTGCCGATCCTCAGAGATGGGCCTCGACTTTTTTCCTGTTTACAGCATCACCGCCTGTAGGATTGACTGTGAGACCCGCTACATTGTGGAAAACTGCAACTGCCGCATGGTTCACATGCCAGGGGATGCCCCTTTTTGTACCCCTGAGCAGCACAAGGAGTGTGCAGAGCCTGCCCTAGGTCTGTTGGCGGAAAAGGACAGCAATTACTGTCTCTGCAGGACACCCTGCAACCTAACCCGCTACAACAAAGAGCTCTCCATGGTGAAGATCCCCAGCAAGACATCAGCCAAGTACCTTGAGAAGAAATTTAACAAATCAGAAAAATATATCTCAGAGAACATCCTTGTTCTGGATATATTTTTTGAAGCTCTCAATTATGAGACAATTGAACAGAAGAAGGCGTATGAAGTTGCTGCCTTACTTGGTGATATTGGTGGTCAGATGGGATTGTTCATTGGTGCTAGTATCCTTACAATACTAGAGCTCTTTGATTATATTTATGAGCTGATCAAAGAGAAGCTATTAGACCTGCTTGGCAAAGAGGAGGACGAAGGGAGCCACGATGAGAATGTGAGTACTTGTGACACAATGCCAAACCACTCTGAAACCATCAGTCACGCTGTGAACGTGCCCCTGCAGACGACCCTGGGGACCTTGGAGGAGATTGCCTGCTGA

Protein sequence + ...

MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISHTVNVPLQTTLGTLEEIAC

GO Classification
component
intrinsic to membrane
integral to membrane
membrane
cell
function
cation channel activity
transporter activity
sodium channel activity
amiloride-sensitive sodium channel activity
ion transporter activity
ion channel activity
process
cation transport
monovalent inorganic cation transport
physiological process
sodium ion transport
cellular physiological process
transport
ion transport
See more information at   →   www.drugbank.ca
Id Name
DB00594 Amiloride
Id Name
DB00013 Urokinase
DB00122 Choline
DB00123 L-Lysine
DB00125 L-Arginine
DB00127 Spermine
DB00152 Thiamine
DB00184 Nicotine
DB00206 Reserpine
DB00220 Nelfinavir
DB00224 Indinavir
DB00242 Cladribine
DB00264 Metoprolol
DB00280 Disopyramide
DB00318 Codeine
DB00331 Metformin
DB00332 Ipratropium bromide
DB00345 Aminohippurate
DB00365 Grepafloxacin
DB00368 Norepinephrine
DB00384 Triamterene
DB00396 Progesterone
DB00406 Gentian Violet
DB00413 Pramipexole
DB00457 Prazosin
DB00458 Imipramine
DB00468 Quinine
DB00477 Chlorpromazine
DB00495 Zidovudine
DB00501 Cimetidine
DB00515 Cisplatin
DB00520 Caspofungin
DB00526 Oxaliplatin
DB00536 Guanidine
DB00570 Vinblastine
DB00571 Propranolol
DB00575 Clonidine
DB00583 L-Carnitine
DB00586 Diclofenac
DB00594 Amiloride
DB00619 Imatinib
DB00624 Testosterone
DB00654 Latanoprost
DB00661 Verapamil
DB00667 Histamine Phosphate
DB00668 Epinephrine
DB00683 Midazolam
DB00690 Flurazepam
DB00694 Daunorubicin
DB00709 Lamivudine
DB00728 Rocuronium
DB00783 Estradiol
DB00787 Acyclovir
DB00863 Ranitidine
DB00907 Cocaine
DB00908 Quinidine
DB00914 Phenformin
DB00915 Amantadine
DB00917 Dinoprostone
DB00925 Phenoxybenzamine
DB00927 Famotidine
DB00987 Cytarabine
DB00988 Dopamine
DB01004 Ganciclovir
DB01032 Probenecid
DB01035 Procainamide
DB01043 Memantine
DB01053 Penicillin G
DB01075 Diphenhydramine
DB01103 Quinacrine
DB01114 Chlorpheniramine
DB01137 Levofloxacin
DB01151 Desipramine
DB01160 Dinoprost Tromethamine
DB01165 Ofloxacin
DB01193 Acebutolol
DB01199 Tubocurarine
DB01232 Saquinavir
DB01337 Pancuronium
DB01339 Vecuronium
DB01409 Tiotropium
DB01580 Oxprenolol
DB01614 Acepromazine
DB01621 Pipotiazine
DB01622 Thioproperazine
DB01623 Thiothixene
DB01905 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
DB01917 Putrescine
DB01977 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine
DB02193 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine
DB02398 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine
DB02473 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
DB02526 CRA_10655
DB02533 Aminoguanidine
DB02551 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
DB02624 Homoserine Lactone
DB02705 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine
DB03046 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide
DB03082 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide
DB03127 Benzamidine
DB03128 Acetylcholine
DB03136 4-Iodobenzo[B]Thiophene-2-Carboxamidine
DB03159 CRA_8696
DB03476 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine
DB03566 Spermidine
DB03608 Diminazene
DB03729 2-Amino-5-Hydroxy-Benzimidazole
DB03782 N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)Urea
DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
DB03876 Thieno[2,3-B]Pyridine-2-Carboxamidine
DB04059 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide
DB04172 [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine
DB04348 Taurocholic Acid
DB04485 Deoxythymidine
DB04574 Estropipate
DB04830 Buformin
DB06691 Mepyramine
DB06854 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB06855 6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE
DB06856 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE
DB06857 N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE
DB07076 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE
DB07122 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine
DB07129 (2R)-1-(2,6-dimethylphenoxy)propan-2-amine
DB07625 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide
DB07626 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
DB08072 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE
DB08697 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
DB08837 Tetraethylammonium
DB08838 Agmatine