DT-Web

DB01623 - Thiothixene


Identification
Name Thiothixene
Accession Number DB01623
Type small molecule
Description A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 443.625
Groups approved
Monoisotopic Weight 443.170118567
Pharmacology
Indication For the management of schizophrenia.
Mechanism of action Thiothixene acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, and weakness.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Abarelix May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Amantadine Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Amantadine. Consider alternate therapy or monitor for decreased effects of both agents.
Amiodarone May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Amitriptyline May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Amoxapine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Apomorphine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Thiothixene may also antagonize the effects of the anti-Parkinsonian agent, Apomorphine. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or doses changed.
Arsenic trioxide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Bromocriptine Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Bromocriptine. Consider alternate therapy or monitor for decreased effects of both agents.
Chlorpromazine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ciprofloxacin The strong CYP1A2 inhibitor, Ciprofloxacin, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Ciprofloxacin is initiated, discontinued or dose changed.
Cisapride May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Clarithromycin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Clomipramine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Dasatinib May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Desipramine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Disopyramide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Dofetilide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Dolasetron May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Domperidone May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Donepezil Possible antagonism of action
Doxepin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Droperidol May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Erythromycin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Flecainide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Fluconazole May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Fluoxetine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Flupenthixol May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Fluvoxamine The strong CYP1A2 inhibitor, Fluvoxamine, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Fluvoxamine is initiated, discontinued or dose changed.
Foscarnet May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Galantamine Possible antagonism of action
Gatifloxacin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Guanethidine Thiothixene may decrease the effect of guanethidine.
Halofantrine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Haloperidol May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ibutilide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Imipramine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Indapamide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Isradipine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ketoconazole The strong CYP1A2 inhibitor, Ketoconazole, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Ketoconazole is initiated, discontinued or dose changed.
Lapatinib May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Levodopa Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Levodopa. Consider alternate therapy or monitor for decreased effects of both agents.
Levofloxacin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Lidocaine The strong CYP1A2 inhibitor, Lidocaine, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Lidocaine is initiated, discontinued or dose changed.
Loxapine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Maprotiline May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Mefloquine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Mesoridazine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Methadone May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Methoxsalen The strong CYP1A2 inhibitor, Methoxsalen, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Methoxsalen is initiated, discontinued or dose changed.
Mexiletine The strong CYP1A2 inhibitor, Mexiletine, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Mexiletine is initiated, discontinued or dose changed.
Moxifloxacin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Nilotinib May cause additive QTc-prolonging effects. Concomitant therapy should be avoided.
Norfloxacin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. The strong CYP1A2 inhibitor, Norfloxacin, may also decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or dose changed. Thorough risk:benefit assessment is required prior to co-administration.
Nortriptyline May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Octreotide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ofloxacin The strong CYP1A2 inhibitor, Ofloxacin, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Ofloxacin is initiated, discontinued or dose changed.
Pentamidine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Perflutren May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Pergolide Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Pergolide. Consider alternate therapy or monitor for decreased effects of both agents.
Pimozide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Pramipexole Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Pramipexole. Consider alternate therapy or monitor for decreased effects of both agents.
Pramlintide The anticholinergic effects of Tranylcypromine may be enhanced by Pramlintide. Additive effects of reduced GI motility may occur. Pramlintide slows gastic emptying and should not be used with drugs that alter GI motility (e.g. anticholinergics). Consider alternative treatments or use caution during concomitant therapy.
Primaquine The strong CYP1A2 inhibitor, Primaquine, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Primaquine is initiated, discontinued or dose changed.
Probucol May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Procainamide May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Propafenone May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Protriptyline May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Quetiapine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Quinine May cause additive QTc-prolonging effects. Concomitant therapy should be avoided.
Ranolazine May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Risperidone May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ropinirole Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Ropinirole. Consider alternate therapy or monitor for decreased effects of both agents.
Rotigotine Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Rotigotine. Consider alternate therapy or monitor for decreased effects of both agents.
Sotalol May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Sparfloxacin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Sunitinib May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Thiothixene, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents.
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telithromycin May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Tetrabenazine Additive QTc prolongation may occur. QTc prolongation can lead to Torsade de Pointes (TdP). Concomitant therapy should be avoided.
Thiabendazole The strong CYP1A2 inhibitor, Thiobendazole, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Thiobendazole is initiated, discontinued or dose changed.
Thioridazine May cause additive QTc-prolonging effects. Concomitant therapy is contraindicated.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trimethobenzamide Trimethobenzamide and Thiothixene, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Triprolidine Triprolidine and Thiothixene, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Thiothixene, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Voriconazole Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy should be avoided.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions
  • Avoid alcohol

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Shultz PJ, Sedor JR, Abboud HE: Dopaminergic stimulation of cAMP accumulation in cultured rat mesangial cells. Am J Physiol. 1987 Aug;253(2 Pt 2):H358-64. - Pubmed
  • Oades RD, Rao ML, Bender S, Sartory G, Muller BW: Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy. Behav Pharmacol. 2000 Jun;11(3-4):317-30. - Pubmed
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Wu S, Xing Q, Gao R, Li X, Gu N, Feng G, He L: Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. Neurosci Lett. 2005 Mar 7;376(1):1-4. Epub 2004 Dec 2. - Pubmed
  • Wu SN, Gao R, Xing QH, Li HF, Shen YF, Gu NF, Feng GY, He L: Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. Acta Pharmacol Sin. 2006 Aug;27(8):966-70. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Seeman P: Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses. 2010 Apr;4(1):56-73. - Pubmed
DTHybrid score 0.4409
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions antagonist
References
  • Shultz PJ, Sedor JR, Abboud HE: Dopaminergic stimulation of cAMP accumulation in cultured rat mesangial cells. Am J Physiol. 1987 Aug;253(2 Pt 2):H358-64. - Pubmed
  • Kanba S, Suzuki E, Nomura S, Nakaki T, Yagi G, Asai M, Richelson E: Affinity of neuroleptics for D1 receptor of human brain striatum. J Psychiatry Neurosci. 1994 Jul;19(4):265-9. - Pubmed
DTHybrid score 0.3405
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Kusumi I, Takahashi Y, Suzuki K, Kameda K, Koyama T: Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain. J Neural Transm. 2000;107(3):295-302. - Pubmed
  • Yamada J, Sugimoto Y, Horisaka K: Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice. Biol Pharm Bull. 1995 Nov;18(11):1580-3. - Pubmed
DTHybrid score 0.3418

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3546
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4259

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions Not Available
References
  • Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
DTHybrid score 0.2479

Carriers


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions
References Not Available
DTHybrid score 0.2479

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2819
1588 Multidrug resistance protein 1 ABCB1 0.1696
4757 Cytochrome P450 2C9 CYP2C9 0.1661
556 Alpha-1A adrenergic receptor ADRA1A 0.1562
6016 Cytochrome P450 2C19 CYP2C19 0.1508
320 5-hydroxytryptamine 1A receptor HTR1A 0.1478
590 5-hydroxytryptamine 2C receptor HTR2C 0.1359
318 Alpha-2A adrenergic receptor ADRA2A 0.1292
638 D(3) dopamine receptor DRD3 0.1242
432 D(4) dopamine receptor DRD4 0.1147
632 Alpha-1B adrenergic receptor ADRA1B 0.1081
4118 Cytochrome P450 3A5 CYP3A5 0.1044
163 D(1B) dopamine receptor DRD5 0.101
492 Histamine H1 receptor HRH1 0.1008
4924 Cytochrome P450 2C8 CYP2C8 0.0995
629 Alpha-2B adrenergic receptor ADRA2B 0.0913
378 Alpha-2C adrenergic receptor ADRA2C 0.0895
6013 Cytochrome P450 2E1 CYP2E1 0.0887
103 Muscarinic acetylcholine receptor M1 CHRM1 0.088
6030 Cytochrome P450 2B6 CYP2B6 0.0863
6144 Solute carrier family 22 member 2 SLC22A2 0.0856
6107 Cytochrome P450 3A7 CYP3A7 0.0812
436 5-hydroxytryptamine 2B receptor HTR2B 0.077
6024 Cytochrome P450 1A1 CYP1A1 0.0737
824 Sodium-dependent serotonin transporter SLC6A4 0.0697
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0672
725 5-hydroxytryptamine 1D receptor HTR1D 0.0668
885 5-hydroxytryptamine 1B receptor HTR1B 0.0638
617 Muscarinic acetylcholine receptor M2 CHRM2 0.06
716 5-hydroxytryptamine 7 receptor HTR7 0.059
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0582
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0538
118 Organic cation/carnitine transporter 2 SLC22A5 0.0498
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0491
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0478
789 Alpha-1D adrenergic receptor ADRA1D 0.0475
1729 Solute carrier family 22 member 6 SLC22A6 0.0465
20 Prostaglandin G/H synthase 1 PTGS1 0.0451
5718 Cytochrome P450 2A6 CYP2A6 0.0428
6147 Solute carrier family 22 member 3 SLC22A3 0.0415
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0407
1256 5-hydroxytryptamine 6 receptor HTR6 0.0405
193 Beta-1 adrenergic receptor ADRB1 0.0375
341 5-hydroxytryptamine 3 receptor HTR3A 0.0368
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0359
3941 Amine oxidase [flavin-containing] A MAOA 0.0355
713 Sodium-dependent dopamine transporter SLC6A3 0.0352
220 Sodium channel protein type 5 subunit alpha SCN5A 0.035
833 Organic cation/carnitine transporter 1 SLC22A4 0.0348
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0341
766 Beta-2 adrenergic receptor ADRB2 0.034
6142 Solute carrier family 22 member 8 SLC22A8 0.0334
465 Calmodulin CALM1 0.0327
36 Insulin receptor INSR 0.0325
3923 Cholinesterase BCHE 0.0318
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0302
290 Prostaglandin G/H synthase 2 PTGS2 0.0289
6106 Cytochrome P450 2C18 CYP2C18 0.0269
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0268
862 Multidrug resistance-associated protein 1 ABCC1 0.0258
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0255
474 Acetylcholinesterase ACHE 0.025
94 5-hydroxytryptamine 4 receptor HTR4 0.0244
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0243
891 Dihydropteroate synthase folP 0.0232
5359 Dihydropteroate synthase folP 0.0232
7175 Dihydropteroate synthase sulI 0.0232
3939 Amine oxidase [flavin-containing] B MAOB 0.023
131 Synaptic vesicular amine transporter SLC18A2 0.0217
1898 Cytochrome P450 1B1 CYP1B1 0.0217
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0214
174 Sigma 1-type opioid receptor SIGMAR1 0.0214
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0211
6143 Solute carrier family 22 member 7 SLC22A7 0.0209
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0205
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.02
776 Bile salt export pump ABCB11 0.0189
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0181
1024 Solute carrier family 22 member 11 SLC22A11 0.0177
124 Histamine H2 receptor HRH2 0.0174
528 5-hydroxytryptamine 1E receptor HTR1E 0.0171
847 Mu-type opioid receptor OPRM1 0.017
2164 Multidrug resistance-associated protein 4 ABCC4 0.017
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0169
1389 Transforming growth factor beta-1 TGFB1 0.0169
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0161
696 Kappa-type opioid receptor OPRK1 0.0161
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0161
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0158
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0152
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0152
923 Glutamate receptor 3 GRIA3 0.0149
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0147
3811 Cytochrome P450 19A1 CYP19A1 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0137
467 Delta-type opioid receptor OPRD1 0.0136
817 DNA topoisomerase 2-alpha TOP2A 0.0128
731 HIV-1 protease HIV-1 protease 0.0128
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
136 Estrogen receptor ESR1 0.012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0118
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0118
3426 Glutamine synthetase glnA 0.0118
3987 Glutamine synthetase GLUL 0.0118
756 Sex hormone-binding globulin SHBG 0.0117
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0116
380 Cytochrome P450 17A1 CYP17A1 0.0112
921 Glutamate receptor 2 GRIA2 0.0107
6432 Transporter snf 0.0101
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0099
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0099
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0098
2211 Fatty acid-binding protein, heart FABP3 0.0098
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0096
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0095
3947 Xanthine dehydrogenase/oxidase XDH 0.0095
566 Serotransferrin TF 0.0094
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0094
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0093
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0093
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0092
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0092
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0091
672 Prostaglandin F2-alpha receptor PTGFR 0.009
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0088
6148 Multidrug resistance-associated protein 7 ABCC10 0.0087
6141 Sodium/bile acid cotransporter SLC10A1 0.0086
738 Monocarboxylate transporter 1 SLC16A1 0.0085
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0085
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0085
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0082
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0081
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
482 Glycine receptor subunit alpha-1 GLRA1 0.008
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0079
694 Matrix protein 2 M 0.0078
537 ATP synthase delta chain, mitochondrial ATP5D 0.0078
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0077
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0077
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0077
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0076
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0075
16 Adenosine A1 receptor ADORA1 0.0075
373 Transthyretin TTR 0.0074
869 Estrogen receptor beta ESR2 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
705 Glutamate receptor 1 GRIA1 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
1517 Beta-3 adrenergic receptor ADRB3 0.0072
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
6014 Cytochrome P450 2A13 CYP2A13 0.0072
844 Epidermal growth factor receptor EGFR 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
645 Penicillin-binding protein 1A mrcA 0.0071
5805 Penicillin-binding protein 1A ponA 0.0071
6185 Penicillin-binding protein 1A mrcA 0.0071
6799 Penicillin-binding protein 1A pbpA 0.0071
1178 Adenosine A2a receptor ADORA2A 0.0071
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
1656 CYP2B protein CYP2B 0.0068
164 Histamine H4 receptor HRH4 0.0068
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0066
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0066
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0066
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
6070 Nischarin NISCH 0.0065
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0065
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0065
4604 Liver carboxylesterase 1 CES1 0.0064
4773 Deoxycytidine kinase DCK 0.0064
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
173 Toll-like receptor 7 TLR7 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
565 Extracellular calcium-sensing receptor CASR 0.0062
183 Vascular endothelial growth factor A VEGFA 0.0062
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0062
6220 Aryl hydrocarbon receptor AHR 0.0061
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0061
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0061
6085 Fatty acid-binding protein, intestinal FABP2 0.0061
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0061
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0061
146 Androgen receptor AR 0.006
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.006
70 Type-1 angiotensin II receptor AGTR1 0.0059
153 Dopamine beta-hydroxylase DBH 0.0058
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0058
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0058
6031 Cytochrome P450 3A43 CYP3A43 0.0057
468 Cytochrome P450 4A11 CYP4A11 0.0057
504 Mast/stem cell growth factor receptor KIT 0.0057
6151 Monocarboxylate transporter 10 SLC16A10 0.0057
904 Glutathione S-transferase P GSTP1 0.0056
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0055
6859 Protein S100-A4 S100A4 0.0055
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0054
871 Glucocorticoid receptor NR3C1 0.0054
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0053
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0053
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0053
777 Tumor necrosis factor TNF 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
6136 Multidrug resistance-associated protein 5 ABCC5 0.0053
122 P2Y purinoceptor 12 P2RY12 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
1830 5'-nucleotidase NT5E 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0052
1757 Myeloperoxidase MPO 0.0051
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.005
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.005
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.005
1618 High affinity nerve growth factor receptor NTRK1 0.005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.005
427 Substance-P receptor TACR1 0.005
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.005
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.005
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.005
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
3810 Catechol O-methyltransferase COMT 0.0049
228 Beta platelet-derived growth factor receptor PDGFRB 0.0049
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0049
6171 Solute carrier family 28 member 3 SLC28A3 0.0049
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0049
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0049
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
6102 Arylamine N-acetyltransferase 2 NAT2 0.0048
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0048
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0047
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0047
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0044
2112 Toll-like receptor 9 TLR9 0.0044
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
828 Phenylalanine-4-hydroxylase PAH 0.0043
3109 Phenylalanine-4-hydroxylase phhA 0.0043
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0043
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0043
511 5-hydroxytryptamine 1F receptor HTR1F 0.0043
6182 Cytochrome P450 2J2 CYP2J2 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
4122 Histone deacetylase 2 HDAC2 0.0042
273 Apoptosis regulator Bcl-2 BCL2 0.0041
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0041
4203 Histamine N-methyltransferase HNMT 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.004
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.004
1050 Bile salt sulfotransferase SULT2A1 0.004
558 Solute carrier family 12 member 1 SLC12A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.004
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0039
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0039
459 Retinoic acid receptor RXR-alpha RXRA 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
614 Progesterone receptor PGR 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
2472 Voltage-gated potassium channel kcsA 0.0038
6366 Voltage-gated potassium channel kcsA 0.0038
33 Cystine/glutamate transporter SLC7A11 0.0038
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0038
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0038
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0038
3932 Glutathione S-transferase A2 GSTA2 0.0037
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0037
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0036
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0036
6043 Putative G-protein coupled receptor 44 GPR44 0.0036
1341 Histamine H3 receptor HRH3 0.0036
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0036
6149 Solute carrier family 22 member 10 SLC22A10 0.0036
4228 Keratin, type II cytoskeletal 7 KRT7 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0036
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0036
1360 Sphingomyelin phosphodiesterase SMPD1 0.0036
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0036
6137 Multidrug resistance-associated protein 6 ABCC6 0.0035
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0035
976 Platelet glycoprotein IX GP9 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
1864 RET proto-oncogene RET 0.0035
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0034
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0034
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0034
125 DNA polymerase beta POLB 0.0034
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0034
712 Tubulin alpha chain TUB1 0.0034
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0034
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0033
6506 Stathmin-4 STMN4 0.0033
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0033
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0033
6146 High affinity copper uptake protein 1 SLC31A1 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
365 Dihydrofolate reductase DHFR 0.0033
2381 Dihydrofolate reductase DFR1 0.0033
2833 Dihydrofolate reductase Not Available 0.0033
2931 Dihydrofolate reductase folA 0.0033
3544 Dihydrofolate reductase folA 0.0033
3682 Dihydrofolate reductase folA 0.0033
6642 Dihydrofolate reductase folA 0.0033
6756 Dihydrofolate reductase dfrA 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0032
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0032
594 Thyroxine-binding globulin SERPINA7 0.0032
707 72 kDa type IV collagenase MMP2 0.0032
811 Translocator protein TSPO 0.0032
6677 Myelin P2 protein PMP2 0.0032
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0032
595 Fibrinogen alpha chain FGA 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
260 Cytochrome P450 51 ERG11 0.0031
761 Cytochrome P450 51 ERG11 0.0031
3163 Cytochrome P450 51 cyp51 0.0031
26 Vascular endothelial growth factor receptor 3 FLT4 0.0031
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0031
6167 Organic solute transporter subunit beta OSTB 0.0031
6166 Organic solute transporter subunit alpha OSTA 0.0031
818 50S ribosomal protein L10 rplJ 0.003
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
5626 Nucleoside diphosphate kinase B NME2 0.003
758 Thyroid hormone receptor alpha THRA 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
32 Vascular endothelial growth factor receptor 1 FLT1 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
5126 Arginase rocF 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
1010 Cytochrome P450 51A1 CYP51A1 0.0028
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
65 Matrix metalloproteinase-9 Not Available 0.0028
1629 Transcription factor AP-1 JUN 0.0028
1714 Mitogen-activated protein kinase 3 MAPK3 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0027
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0027
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
2300 Lysozyme E 0.0027
3633 Lysozyme R 0.0027
5597 Lysozyme 17 0.0027
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0027
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0027
346 Thyroid hormone receptor beta-1 THRB 0.0027
407 Vascular endothelial growth factor receptor 2 KDR 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
740 Argininosuccinate synthase ASS1 0.0027
865 Argininosuccinate synthase ASS1 0.0027
2680 Argininosuccinate synthase argG 0.0027
3194 Argininosuccinate synthase argG 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
3957 Adenosine deaminase ADA 0.0026
1992 Vitamin D-binding protein GC 0.0026
229 Retinoic acid receptor beta RARB 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
780 Retinoic acid receptor RXR-gamma RXRG 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
730 Retinoic acid receptor alpha RARA 0.0026
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0026
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0026
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0026
4252 Penicillin-binding protein 5 dacA 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0025
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0025
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0025
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0025
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0025
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0025
161 Tubulin beta chain TUBB 0.0024
312 Tubulin beta chain TUB2 0.0024
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0024
6020 Aldehyde oxidase AOX1 0.0024
5294 Nucleoside diphosphate kinase A NME1 0.0024
1867 Major prion protein PRNP 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0024
88 Retinoic acid receptor RXR-beta RXRB 0.0024
6231 Pepsin A PGA3 0.0024
244 Angiotensin-converting enzyme ACE 0.0024
162 Retinoic acid receptor gamma-1 RARG 0.0024
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0024
633 Penicillin-binding proteins 1A/1B pbpA 0.0024
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0023
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0023
518 Peroxidase/catalase T katG 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
5787 Angiopoietin-1 receptor TEK 0.0023
275 Arachidonate 5-lipoxygenase ALOX5 0.0023
751 Potassium channel subfamily K member 6 KCNK6 0.0023
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0023
4311 tRNA TRDMT1 0.0022
4325 tRNA trmD 0.0022
4328 tRNA trmD 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
6103 Arylamine N-acetyltransferase 1 NAT1 0.0022
6218 Pannexin-1 PANX1 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
6165 Copper-transporting ATPase 1 ATP7A 0.0021
6163 Copper-transporting ATPase 2 ATP7B 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6209 30S ribosomal protein S19 rpsS 0.0021
6712 30S ribosomal protein S19 rpsS 0.0021
6726 30S ribosomal protein S19 rpsS 0.0021
6207 30S ribosomal protein S14 rpsN 0.0021
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.0021
172 Potassium channel subfamily K member 1 KCNK1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.002
737 Mineralocorticoid receptor NR3C2 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.002
563 Thyroid peroxidase TPO 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
158 Sodium channel protein type 1 subunit alpha SCN1A 0.002
768 FK506-binding protein 1A FKBP1A 0.002
342 P protein [Includes: DNA-directed DNA polymerase P 0.002
612 P protein [Includes: DNA-directed DNA polymerase P 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
1820 Beta-nerve growth factor NGF 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
822 Aldose reductase AKR1B1 0.002
3856 Fibroblast growth factor receptor 3 FGFR3 0.0019
2449 Tubulin alpha-3 chain TUBA1A 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
4120 NADPH--cytochrome P450 reductase POR 0.0019
4226 Uridine phosphorylase 2 UPP2 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
2207 Rhodopsin RHO 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0019
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0019
6033 High affinity interleukin-8 receptor A CXCR1 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0018
1192 Sulfotransferase 1A1 SULT1A1 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4225 Uridine phosphorylase 1 UPP1 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0018
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0018
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0018
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
702 UMP-CMP kinase CMPK1 0.0017
896 Glutathione S-transferase Mu 1 GSTM1 0.0017
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
1648 Elastin ELN 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
413 Amidophosphoribosyltransferase PPAT 0.0017
2515 Amidophosphoribosyltransferase purF 0.0017
3714 Amidophosphoribosyltransferase purF 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0016
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0016
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
3924 Phospholipase D1 PLD1 0.0016
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
3937 Fatty-acid amide hydrolase FAAH 0.0016
1243 Cathepsin D CTSD 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
24 Thymidylate synthase TMP1 0.0015
359 Thymidylate synthase TYMS 0.0015
2626 Thymidylate synthase thyA 0.0015
2729 Thymidylate synthase thyA 0.0015
5352 Thymidylate synthase THYA 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
357 Carbonic anhydrase 2 CA2 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3086 Plasmepsin-2 Not Available 0.0014
489 Monocarboxylate transporter 2 SLC16A7 0.0014
823 Fibroblast growth factor receptor 2 FGFR2 0.0014
1374 Natriuretic peptides B NPPB 0.0014
1827 Gap junction alpha-1 protein GJA1 0.0014
1908 Vascular cell adhesion protein 1 VCAM1 0.0014
4103 Proteasome subunit beta type 2 PSMB2 0.0014
4102 Proteasome subunit beta type 5 PSMB5 0.0014
4101 Proteasome subunit beta type 1 PSMB1 0.0014
233 Potassium channel subfamily K member 2 KCNK2 0.0014
2091 Endoplasmin HSP90B1 0.0014
4148 Serine/threonine-protein kinase mTOR MTOR 0.0014
2981 Phospholipase A2, membrane associated PLA2G2A 0.0014
3639 Thymidine phosphorylase deoA 0.0014
3936 Thymidine phosphorylase TYMP 0.0014
208 DNA-directed RNA polymerase beta' chain rpoC 0.0014
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0014
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
3404 Exotoxin A eta 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
814 Ryanodine receptor 1 RYR1 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0013
1268 Neuropeptide S receptor NPSR1 0.0013
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0013
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0013
6459 Glycodelin PAEP 0.0013
295 Carbonic anhydrase 1 CA1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0012
165 FL cytokine receptor FLT3 0.0012
232 Corticosteroid-binding globulin SERPINA6 0.0012
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0012
3587 Gastrotropin FABP6 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0012
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
268 Adenosine A2b receptor ADORA2B 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
473 L-lactate dehydrogenase A chain LDHA 0.0011
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
2290 ADP-ribosyl cyclase 2 BST1 0.001
239 Coagulation factor X F10 0.001
4237 50S ribosomal protein L22 rplV 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
7 Nitric oxide synthase, inducible NOS2 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
144 Hemoglobin subunit alpha HBA1 0.001
6228 Nuclear receptor coactivator 1 NCOA1 0.001
2021 Thrombomodulin THBD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.001
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.001
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.001
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.001
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.001
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.001
760 Fibroblast growth factor 1 FGF1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
2320 Thymidine kinase, cytosolic TK1 0.0009
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0009
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
1262 Corticotropin-lipotropin POMC 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
3830 Calreticulin CALR 0.0008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0008
6126 Carbonic anhydrase 7 CA7 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
291 Nitric-oxide synthase, endothelial NOS3 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
6042 Prostaglandin reductase 2 PTGR2 0.0007
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0007
581 Cytochrome P450 2R1 CYP2R1 0.0007
5818 Folate receptor alpha FOLR1 0.0007
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0007
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
1792 Tissue-type plasminogen activator PLAT 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
592 Carbonic anhydrase 4 CA4 0.0006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
1630 Integrin beta-2 ITGB2 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
2216 Fibroblast growth factor receptor 4 FGFR4 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
1650 Heme carrier protein 1 SLC46A1 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
856 Vitamin D3 receptor VDR 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
5961 Insulin INS 0.0005
369 Coagulation factor VII F7 0.0005
6824 Tyrosine-protein kinase Lyn LYN 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0003
469 Annexin A1 ANXA1 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
4943 Cytochrome c6 petJ 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4942 Diheme cytochrome c napB napB 0.0003
5000 HemO hemO 0.0003
4916 Cyanoglobin glbN 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4984 Neuroglobin NGB 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4961 Hemophore HasA hasA 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4952 Catalase/peroxidase katA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
54 Prothrombin F2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
4920 Peroxidase/catalase katG 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
4990 PpcA ppcA 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
↑