DT-Web: DB01242

Identification

Name

Clomipramine

Accession Number

DB01242 (APRD00253, DB07600)

Type

small molecule

Description

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette's disorder). Unlabeled indications include panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy, autistic disorder, trichotillomania, onchophagia, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine is rapidly absorbed from the gastrointestinal tract and demethylated in the liver to its primary active metabolite, desmethylclomipramine.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

314.852

Groups

approved

Monoisotopic Weight

314.154976453

Pharmacology

Indication

May be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette's disorder). Unlabeled indications include: depression, panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy (limited evidence), autistic disorder (limited evidence), trichotillomania (limited evidence), onchophagia (limited evidence), stuttering (limited evidence), premature ejaculation, and premenstrual syndrome.

Mechanism of action

Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. α₁-receptor blockage and β-down-regulation have been noted and most likely play a role in the short term effects of clomipramine. A blockade of sodium-channels and NDMA-receptors might, as with other tricyclics, account for its effect in chronic pain, in particular the neuropathic type.

Absorption

Well absorbed from the GI tract following oral administration. Bioavailability is approximately 50% orally due to extensive first-pass metabolism. Bioavailability is not affected by food. Peak plasma concentrations occurred 2-6 hours following oral administration of a single 50 mg dose. The peak plasma concentration ranged from 56 ng/mL to 154 mg/mL (mean, 92 ng/mL). There are large interindividual variations in plasma concentrations occur, partly due to genetic differences in clomipramine metabolism. On average, steady state plasma concentrations are achieved in 1-2 weeks following multiple dose oral administration. Smoking appears to lower the steady-state plasma concentration of clomipramine, but not its active metabolite desmethylclomipramine.

Protein binding

Clomipramine is approximately 97-98% bound to plasma proteins, principally to albumin and possibly to α₁-acid glycoprotein. Desmethylclomipramine is 97-99% bound to plasma proteins.

Biotransformation

Extensively metabolized in the liver. The main active metabolite is desmethylclomipramine, which is formed by N-demethylation of clomipramine via CYP2C19, 3A4 and 1A2. Other metabolites and their glucuronide conjugates are also produced. Other metabolites of clomipramine include 8-hydroxyclomipramine formed via 8-hydroxylation, 2-hydroxyclomipramine formed via 2-hydroxylation, and clomipramine N-oxide formed by N-oxidation. Desmethylclomipramine is further metabolized to 8-hydroxydesmethylclomipramine and didesmethylclomipramine, which are formed by 8-hydroxylation and N-demethylation, respectively. 8-Hydroxyclomipramine and 8-hydroxydesmethylclomipramine are pharmacologically active; however, their clinical contribution remains unknown.

Route of elimination

Urine (51-60%) and feces via biliary elimination (24-32%)

Toxicity

Signs and symptoms vary in severity depending upon factors such as the amount of drug absorbed, the age of the patient, and the time elapsed since drug ingestion. Critical manifestations of overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity. In U.S. clinical trials, 2 deaths occurred in 12 reported cases of acute overdosage with Anafranil either alone or in combination with other drugs. One death involved a patient suspected of ingesting a dose of 7000 mg. The second death involved a patient suspected of ingesting a dose of 5750 mg. Side effects include: sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Altretamine	Risk of severe hypotension
Artemether	Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir	Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if atazanavir is initiated, discontinued or dose changed.
Butabarbital	Barbiturates like butabarbital may increase the metabolism of tricyclic antidepressants like clomipramine. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Butalbital	Barbiturates such as butalbital may increase the metabolism of tricyclic antidepressants such as clomipramine. Monitor for decreased therapeutic effects of tricyclic antidepressants if a barbiturate is initiated/dose increased, or increased effects if a barbiturate is discontinued/dose decreased. The tricyclic antidepressant dosage will likely need to be increased during concomitant barbiturate therapy, and reduced upon barbiturate discontinuation.
Cimetidine	Cimetidine may increase the effect of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if cimetidine is initiated, discontinued or dose changed.
Cisapride	Increased risk of cardiotoxicity and arrhythmias
Clonidine	The tricyclic antidepressant, clomipramine, may decrease the effect of clonidine.
Desvenlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Dihydroquinidine barbiturate	Dihydroquinidine barbiturate increases the effect of the tricyclic antidepressant, clomipramine.
Dobutamine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of dobutamine.
Donepezil	Possible antagonism of action
Dopamine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of dopamine.
Ephedra	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of ephedra.
Ephedrine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of ephedrine.
Epinephrine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of epinephrine.
Fenoterol	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of fenoterol.
Fluoxetine	The SSRI, fluoxetine, may increase the serum concentration of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of clomipramine if fluoxetine is initiated, discontinued or dose changed.
Fluvoxamine	The SSRI, fluvoxamine, may increase the serum concentration of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Additive modulation of serotonin activity also increases the risk of serotonin syndrome. Monitor for development of serotonin syndrome during concomitant therapy. Monitor for changes in the therapeutic and adverse effects of clomipramine if fluvoxamine is initiated, discontinued or dose changed.
Galantamine	Possible antagonism of action
Grepafloxacin	Increased risk of cardiotoxicity and arrhythmias
Guanethidine	The tricyclic antidepressant, clomipramine, decreases the effect of guanethidine.
Isocarboxazid	Possibility of severe adverse effects
Isoproterenol	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of isoproterenol.
Mephentermine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of mephentermine.
Metaraminol	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of metaraminol.
Methoxamine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of methoxamine.
Moclobemide	Possible severe adverse reaction with this combination
Norepinephrine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of norepinephrine.
Orciprenaline	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of orciprenaline.
Phenelzine	Possibility of severe adverse effects
Phenylephrine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of phenylephrine.
Phenylpropanolamine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of phenylpropanolamine.
Pirbuterol	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of pirbuterol.
Procaterol	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of procaterol.
Pseudoephedrine	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of pseudoephedrine.
Quinidine	Additive QTc-prolonging effects may occur. Quinidine may also increase the serum concentration of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if quinidine is initiated, discontinued or dose changed. Monitor for the development of torsades de pointes during concomitant therapy.
Quinidine barbiturate	Quinidine barbiturate increases the effect of tricyclic antidepressant, clomipramine.
Rasagiline	Possibility of severe adverse effects
Rifabutin	The rifamycin, rifabutin, may decrease the effect of the tricyclic antidepressant, clomipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if rifabutin is initiated, discontinued or dose changed.
Rifampin	The rifamycin, rifampin, may decrease the effect of the tricyclic antidepressant, clomipramine, by increasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if rifampin is initiated, discontinued or dose changed.
Ritonavir	Ritonavir may increase the effect and toxicity of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if ritonavir if initiated, discontinued or dose changed.
Rivastigmine	Possible antagonism of action
Salbutamol	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of salbutamol.
Sibutramine	Increased risk of CNS adverse effects
Sparfloxacin	Increased risk of cardiotoxicity and arrhythmias
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Clomipramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Tacrolimus	Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Tamoxifen	Clomipramine may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Clomipramine, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Clomipramine is initiated, discontinued, or dose changed.
Terbinafine	Terbinafine may reduce the metabolism and clearance of Clomipramine. Consider alternate therapy or monitor for therapeutic/adverse effects of Clomipramine if Terbinafine is initiated, discontinued or dose changed.
Terbutaline	The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of terbutaline.
Terfenadine	Increased risk of cardiotoxicity and arrhythmias
Thiabendazole	The strong CYP1A2 inhibitor, Thiabendazole, may increase the effects and toxicity of Clomipramine by decreasing Clomipramine metabolism and clearance. Monitor for changes in the therapeutic and adverse effects of Clomipramine if Thiabendazole is initiated, discontinued or dose changed.
Thiothixene	May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Ticlopidine	Ticlopidine may decrease the metabolism and clearance of Clomipramine. Consider alternate therapy or monitor for adverse/toxic effects of Clomipramine if Ticlopidine is initiated, discontinued or dose changed.
Toremifene	Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Tramadol	Tramadol increases the risk of serotonin syndrome and seizures. Clomipramine may decrease the effect of Tramadol by decreasing active metabolite production.
Tranylcypromine	Increased risk of serotonin syndrome. Concomitant therapy should be avoided. A significant washout period, dependent on the half-lives of the agents, should be employed between therapies.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimethobenzamide	Trimethobenzamide and Clomipramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trimipramine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome. Additive QTc-prolongation may also occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Triprolidine	Triprolidine and Clomipramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium	Trospium and Clomipramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Vorinostat	Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone	Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zolmitriptan	Use of two serotonin modulators, such as zolmitriptan and clomipramine, increases the risk of serotonin syndrome. Consider alternate therapy or monitor for serotonin syndrome during concomitant therapy.
Zuclopenthixol	Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).

Food Interactions

Take with food to reduce irritation.
Grapefruit and grapefruit juice should be avoided throughout treatment, grapefruit can modify serum levels of clomipramine and its metabolite desmethyl-clomipramine.
Avoid alcohol.

Sodium-dependent serotonin transporter
Name	Sodium-dependent serotonin transporter
Gene Name	SLC6A4
Pharmacological action	yes
Actions	inhibitor
References	Alvarez JC, Gluck N, Arnulf I, Quintin P, Leboyer M, Pecquery R, Launay JM, Perez-Diaz F, Spreux-Varoquaux O: Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine. Clin Pharmacol Ther. 1999 Dec;66(6):617-24. - Pubmed Borkowska A, Pilaczynska E, Araszkiewicz A, Rybakowski J: [The effect of sertraline on cognitive functions in patients with obsessive-compulsive disorder] Psychiatr Pol. 2002 Nov-Dec;36(6 Suppl):289-95. - Pubmed Suhara T, Takano A, Sudo Y, Ichimiya T, Inoue M, Yasuno F, Ikoma Y, Okubo Y: High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography. Arch Gen Psychiatry. 2003 Apr;60(4):386-91. - Pubmed Larsen AK, Brennum LT, Egebjerg J, Sanchez C, Halldin C, Andersen PH: Selectivity of (3)H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects. Br J Pharmacol. 2004 Mar;141(6):1015-23. Epub 2004 Mar 1. - Pubmed Malizia AL, Melichar JM, Brown DJ, Gunn RN, Reynolds A, Jones T, Nutt DJ: Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo. J Psychopharmacol. 1997;11(3):279-81. - Pubmed Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed Gillman PK: Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48. Epub 2007 Apr 30. - Pubmed
DTHybrid score	0.5024
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	yes
Actions	antagonist
References	Hentall ID, Kurle PJ, White TR: Correlations between serotonin level and single-cell firing in the rat's nucleus raphe magnus. Neuroscience. 2000;95(4):1081-8. - Pubmed Contreras CM, Marvan ML, Munoz-Mendez A, Ramirez-Morales A: Cortical and septal responses to dorsal raphe nucleus stimulation in the rat: long-term clomipramine actions. Bol Estud Med Biol. 1992 Jan-Dec;40(1-4):3-7. - Pubmed Sugimoto Y, Inoue K, Yamada J: The tricyclic antidepressant clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep;93(1):74-9. - Pubmed Trifunovic RD, Brodie MS: The effects of clomipramine on the excitatory action of ethanol on dopaminergic neurons of the ventral tegmental area in vitro. J Pharmacol Exp Ther. 1996 Jan;276(1):34-40. - Pubmed Sargent PA, Quested DJ, Cowen PJ: Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors. Psychopharmacology (Berl). 1998 Nov;140(1):120-2. - Pubmed
DTHybrid score	0.4089
5-hydroxytryptamine 2B receptor
Name	5-hydroxytryptamine 2B receptor
Gene Name	HTR2B
Pharmacological action	yes
Actions	antagonist
References	Sargent PA, Quested DJ, Cowen PJ: Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors. Psychopharmacology (Berl). 1998 Nov;140(1):120-2. - Pubmed Sugimoto Y, Inoue K, Yamada J: The tricyclic antidepressant clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep;93(1):74-9. - Pubmed Contreras CM, Marvan ML, Munoz-Mendez A, Ramirez-Morales A: Cortical and septal responses to dorsal raphe nucleus stimulation in the rat: long-term clomipramine actions. Bol Estud Med Biol. 1992 Jan-Dec;40(1-4):3-7. - Pubmed
DTHybrid score	0.2787
5-hydroxytryptamine 2C receptor
Name	5-hydroxytryptamine 2C receptor
Gene Name	HTR2C
Pharmacological action	yes
Actions	antagonist
References	Sargent PA, Quested DJ, Cowen PJ: Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors. Psychopharmacology (Berl). 1998 Nov;140(1):120-2. - Pubmed Sugimoto Y, Inoue K, Yamada J: The tricyclic antidepressant clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep;93(1):74-9. - Pubmed Contreras CM, Marvan ML, Munoz-Mendez A, Ramirez-Morales A: Cortical and septal responses to dorsal raphe nucleus stimulation in the rat: long-term clomipramine actions. Bol Estud Med Biol. 1992 Jan-Dec;40(1-4):3-7. - Pubmed
DTHybrid score	0.3449
Sodium-dependent noradrenaline transporter
Name	Sodium-dependent noradrenaline transporter
Gene Name	SLC6A2
Pharmacological action	unknown
Actions	inhibitor
References	Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed Jungkun G, Kuss HJ, Gsell W: Long-term effects of tricyclic antidepressants on norepinephrine kinetics in humans. J Neural Transm. 2001;108(3):349-62. - Pubmed
DTHybrid score	0.5647
Glutathione S-transferase P
Name	Glutathione S-transferase P
Gene Name	GSTP1
Pharmacological action	unknown
Actions	inhibitor
References	Baranczyk-Kuzma A, Sawicki J, Kuzma M, Jagiello J: [Tricyclic antidepressants as inhibitors of brain glutathione-S-transferase] Pol Merkur Lekarski. 2001 Dec;11(66):472-5. - Pubmed Baranczyk-Kuzma A, Kuzma M, Gutowicz M, Kazmierczak B, Sawicki J: Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta Biochim Pol. 2004;51(1):207-12. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.553
Transporter
Name	Transporter
Gene Name	snf
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.928

Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6769
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Application available online: - The P450 Program Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4295
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table http://www.mentalhealth.com/drug/p30-a01.html - Source Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5013
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Application available online: - The P450 Program Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.7385

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score	0.4963

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.4963

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.348
713	Sodium-dependent dopamine transporter	SLC6A3	0.234
831	D(2) dopamine receptor	DRD2	0.2245
4118	Cytochrome P450 3A5	CYP3A5	0.2198
4924	Cytochrome P450 2C8	CYP2C8	0.2165
6030	Cytochrome P450 2B6	CYP2B6	0.198
556	Alpha-1A adrenergic receptor	ADRA1A	0.1958
6013	Cytochrome P450 2E1	CYP2E1	0.1777
320	5-hydroxytryptamine 1A receptor	HTR1A	0.1775
23	D(1A) dopamine receptor	DRD1	0.175
318	Alpha-2A adrenergic receptor	ADRA2A	0.1745
492	Histamine H1 receptor	HRH1	0.1669
6107	Cytochrome P450 3A7	CYP3A7	0.1598
103	Muscarinic acetylcholine receptor M1	CHRM1	0.1354
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1263
6024	Cytochrome P450 1A1	CYP1A1	0.1211
629	Alpha-2B adrenergic receptor	ADRA2B	0.1151
638	D(3) dopamine receptor	DRD3	0.1123
632	Alpha-1B adrenergic receptor	ADRA1B	0.1118
378	Alpha-2C adrenergic receptor	ADRA2C	0.109
885	5-hydroxytryptamine 1B receptor	HTR1B	0.1052
725	5-hydroxytryptamine 1D receptor	HTR1D	0.1045
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1015
5718	Cytochrome P450 2A6	CYP2A6	0.1005
432	D(4) dopamine receptor	DRD4	0.0962
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0955
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0947
3941	Amine oxidase [flavin-containing] A	MAOA	0.0881
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0859
6145	Solute carrier family 22 member 1	SLC22A1	0.0856
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0837
716	5-hydroxytryptamine 7 receptor	HTR7	0.0828
20	Prostaglandin G/H synthase 1	PTGS1	0.0808
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0784
789	Alpha-1D adrenergic receptor	ADRA1D	0.0774
163	D(1B) dopamine receptor	DRD5	0.0741
131	Synaptic vesicular amine transporter	SLC18A2	0.073
6144	Solute carrier family 22 member 2	SLC22A2	0.0686
6106	Cytochrome P450 2C18	CYP2C18	0.0665
193	Beta-1 adrenergic receptor	ADRB1	0.064
766	Beta-2 adrenergic receptor	ADRB2	0.0639
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0628
3939	Amine oxidase [flavin-containing] B	MAOB	0.062
896	Glutathione S-transferase Mu 1	GSTM1	0.0614
1729	Solute carrier family 22 member 6	SLC22A6	0.0597
4031	Glutathione S-transferase A1	GSTA1	0.0595
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0573
862	Multidrug resistance-associated protein 1	ABCC1	0.0528
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0505
290	Prostaglandin G/H synthase 2	PTGS2	0.0497
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0494
118	Organic cation/carnitine transporter 2	SLC22A5	0.0449
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0431
901	Glutathione S-transferase Mu 4	GSTM4	0.0417
696	Kappa-type opioid receptor	OPRK1	0.0416
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0413
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0412
3923	Cholinesterase	BCHE	0.0412
847	Mu-type opioid receptor	OPRM1	0.0408
6147	Solute carrier family 22 member 3	SLC22A3	0.0406
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0406
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0402
3811	Cytochrome P450 19A1	CYP19A1	0.0386
1898	Cytochrome P450 1B1	CYP1B1	0.0386
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0386
94	5-hydroxytryptamine 4 receptor	HTR4	0.0379
467	Delta-type opioid receptor	OPRD1	0.0379
474	Acetylcholinesterase	ACHE	0.0356
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0352
6142	Solute carrier family 22 member 8	SLC22A8	0.0343
833	Organic cation/carnitine transporter 1	SLC22A4	0.0337
871	Glucocorticoid receptor	NR3C1	0.0328
3759	Glutathione S-transferase	gst	0.0325
4541	Glutathione S-transferase	GST	0.0325
36	Insulin receptor	INSR	0.0325
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.031
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0297
124	Histamine H2 receptor	HRH2	0.0295
731	HIV-1 protease	HIV-1 protease	0.0287
817	DNA topoisomerase 2-alpha	TOP2A	0.0286
136	Estrogen receptor	ESR1	0.0285
776	Bile salt export pump	ABCB11	0.0284
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0283
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0282
6143	Solute carrier family 22 member 7	SLC22A7	0.0274
1656	CYP2B protein	CYP2B	0.0272
2164	Multidrug resistance-associated protein 4	ABCC4	0.0262
891	Dihydropteroate synthase	folP	0.0261
5359	Dihydropteroate synthase	folP	0.0261
7175	Dihydropteroate synthase	sulI	0.0261
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.026
6182	Cytochrome P450 2J2	CYP2J2	0.0248
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0242
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0242
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0239
260	Cytochrome P450 51	ERG11	0.0235
761	Cytochrome P450 51	ERG11	0.0235
3163	Cytochrome P450 51	cyp51	0.0235
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0234
465	Calmodulin	CALM1	0.0228
3932	Glutathione S-transferase A2	GSTA2	0.0226
1024	Solute carrier family 22 member 11	SLC22A11	0.0214
1757	Myeloperoxidase	MPO	0.0211
174	Sigma 1-type opioid receptor	SIGMAR1	0.0209
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0207
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0203
908	Glutathione S-transferase theta-1	GSTT1	0.0199
571	Melatonin receptor type 1A	MTNR1A	0.0199
362	Melatonin receptor type 1B	MTNR1B	0.0199
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0197
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0197
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0196
1313	Lactoylglutathione lyase	GLO1	0.0192
1517	Beta-3 adrenergic receptor	ADRB3	0.019
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0184
468	Cytochrome P450 4A11	CYP4A11	0.0183
477	DNA topoisomerase 4 subunit A	parC	0.0181
886	DNA topoisomerase 4 subunit A	parC	0.0181
6226	DNA topoisomerase 4 subunit A	parC	0.0181
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0179
404	DNA gyrase subunit A	gyrA	0.0178
6224	DNA gyrase subunit A	gyrA	0.0178
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0178
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0178
4041	Microsomal glutathione S-transferase 2	MGST2	0.0178
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0175
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0175
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0174
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0172
6137	Multidrug resistance-associated protein 6	ABCC6	0.0171
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0171
1389	Transforming growth factor beta-1	TGFB1	0.0169
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0169
844	Epidermal growth factor receptor	EGFR	0.0168
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0168
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0167
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0166
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0164
6148	Multidrug resistance-associated protein 7	ABCC10	0.0162
122	P2Y purinoceptor 12	P2RY12	0.0162
6146	High affinity copper uptake protein 1	SLC31A1	0.0161
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0161
6677	Myelin P2 protein	PMP2	0.016
3947	Xanthine dehydrogenase/oxidase	XDH	0.0159
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0159
146	Androgen receptor	AR	0.0157
4604	Liver carboxylesterase 1	CES1	0.0156
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0156
5898	Complement C3	C3	0.0154
1636	Trace amine-associated receptor 1	TAAR1	0.0152
756	Sex hormone-binding globulin	SHBG	0.015
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0146
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0146
614	Progesterone receptor	PGR	0.0146
6031	Cytochrome P450 3A43	CYP3A43	0.0145
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0144
6163	Copper-transporting ATPase 2	ATP7B	0.0144
6165	Copper-transporting ATPase 1	ATP7A	0.0144
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0144
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
2409	Acetyl-CoA acetyltransferase, cytosolic	ACAT2	0.0139
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0138
482	Glycine receptor subunit alpha-1	GLRA1	0.0138
373	Transthyretin	TTR	0.0137
6136	Multidrug resistance-associated protein 5	ABCC5	0.0137
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0135
70	Type-1 angiotensin II receptor	AGTR1	0.0132
777	Tumor necrosis factor	TNF	0.0129
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0129
818	50S ribosomal protein L10	rplJ	0.0128
380	Cytochrome P450 17A1	CYP17A1	0.0127
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0127
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0127
6141	Sodium/bile acid cotransporter	SLC10A1	0.0126
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0125
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0124
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0123
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0123
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0123
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0121
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0119
161	Tubulin beta chain	TUBB	0.0118
312	Tubulin beta chain	TUB2	0.0118
504	Mast/stem cell growth factor receptor	KIT	0.0117
2517	Subtilisin BPN'	apr	0.0116
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0115
869	Estrogen receptor beta	ESR2	0.0113
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0111
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0111
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0111
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0111
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0108
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0107
6220	Aryl hydrocarbon receptor	AHR	0.0106
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0106
2596	Acetyl-CoA acetyltransferase	phbA	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0104
232	Corticosteroid-binding globulin	SERPINA6	0.0103
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0102
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0101
952	Dipeptidyl peptidase 4	DPP4	0.0101
26	Vascular endothelial growth factor receptor 3	FLT4	0.01
183	Vascular endothelial growth factor A	VEGFA	0.0099
4120	NADPH--cytochrome P450 reductase	POR	0.0099
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0099
921	Glutamate receptor 2	GRIA2	0.0099
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0099
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0098
705	Glutamate receptor 1	GRIA1	0.0097
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0097
2443	Azurin	azu	0.0097
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0097
1178	Adenosine A2a receptor	ADORA2A	0.0097
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0097
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0096
32	Vascular endothelial growth factor receptor 1	FLT1	0.0096
407	Vascular endothelial growth factor receptor 2	KDR	0.0095
566	Serotransferrin	TF	0.0094
6014	Cytochrome P450 2A13	CYP2A13	0.0094
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0094
1618	High affinity nerve growth factor receptor	NTRK1	0.0093
738	Monocarboxylate transporter 1	SLC16A1	0.0093
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0092
16	Adenosine A1 receptor	ADORA1	0.0092
244	Angiotensin-converting enzyme	ACE	0.0092
811	Translocator protein	TSPO	0.0089
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0089
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0089
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0088
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0088
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0088
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0088
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0088
6102	Arylamine N-acetyltransferase 2	NAT2	0.0088
4311	tRNA	TRDMT1	0.0087
4325	tRNA	trmD	0.0087
4328	tRNA	trmD	0.0087
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0087
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0087
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0087
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0086
6085	Fatty acid-binding protein, intestinal	FABP2	0.0085
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0084
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0084
1192	Sulfotransferase 1A1	SULT1A1	0.0083
565	Extracellular calcium-sensing receptor	CASR	0.008
3426	Glutamine synthetase	glnA	0.008
3987	Glutamine synthetase	GLUL	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.008
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0079
173	Toll-like receptor 7	TLR7	0.0079
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0078
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0077
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0077
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0076
2449	Tubulin alpha-3 chain	TUBA1A	0.0076
923	Glutamate receptor 3	GRIA3	0.0075
275	Arachidonate 5-lipoxygenase	ALOX5	0.0075
319	Opioid receptor, sigma 1	OPRS1	0.0075
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0074
6043	Putative G-protein coupled receptor 44	GPR44	0.0074
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0073
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0073
1010	Cytochrome P450 51A1	CYP51A1	0.0073
4237	50S ribosomal protein L22	rplV	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
1353	DNA topoisomerase 1	TOP1	0.0072
3552	DNA topoisomerase 1	topA	0.0072
283	SEC14-like protein 2	SEC14L2	0.0072
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0072
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0071
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0071
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0071
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0071
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0071
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.007
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0069
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0069
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0069
6459	Glycodelin	PAEP	0.0068
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0068
4192	DNA topoisomerase 2-beta	TOP2B	0.0067
899	Glutathione S-transferase Mu 3	GSTM3	0.0067
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0067
905	Glutathione transferase omega-1	GSTO1	0.0067
365	Dihydrofolate reductase	DHFR	0.0066
2381	Dihydrofolate reductase	DFR1	0.0066
2833	Dihydrofolate reductase	Not Available	0.0066
2931	Dihydrofolate reductase	folA	0.0066
3544	Dihydrofolate reductase	folA	0.0066
3682	Dihydrofolate reductase	folA	0.0066
6642	Dihydrofolate reductase	folA	0.0066
6756	Dihydrofolate reductase	dfrA	0.0066
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0066
29	Tubulin beta-1 chain	TUBB1	0.0066
4122	Histone deacetylase 2	HDAC2	0.0065
2499	Tubulin beta-2C chain	TUBB2C	0.0065
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0065
273	Apoptosis regulator Bcl-2	BCL2	0.0065
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0064
737	Mineralocorticoid receptor	NR3C2	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
6020	Aldehyde oxidase	AOX1	0.0063
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0062
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0062
2112	Toll-like receptor 9	TLR9	0.0062
1050	Bile salt sulfotransferase	SULT2A1	0.0062
768	FK506-binding protein 1A	FKBP1A	0.0062
592	Carbonic anhydrase 4	CA4	0.0062
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0061
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0061
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0061
3709	Glycerol uptake facilitator protein	glpF	0.0061
3116	Bacterioferritin	bfr	0.0061
4906	Bacterioferritin	bfr	0.0061
4965	Bacterioferritin	bfr	0.0061
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0061
3173	Enolase	eno	0.006
3393	TGF-beta receptor type-2	TGFBR2	0.006
3238	Multidrug resistance protein mexA	mexA	0.006
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
2539	Tubulin alpha-1 chain	TUBA4A	0.0059
427	Substance-P receptor	TACR1	0.0059
558	Solute carrier family 12 member 1	SLC12A1	0.0058
3382	Glycolipid transfer protein	GLTP	0.0058
4238	50S ribosomal protein L4	rplD	0.0058
5578	50S ribosomal protein L4	rplD	0.0058
6173	50S ribosomal protein L4	rplD	0.0058
6219	50S ribosomal protein L4	rplD	0.0058
714	Glutathione reductase, mitochondrial	GSR	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
828	Phenylalanine-4-hydroxylase	PAH	0.0058
3109	Phenylalanine-4-hydroxylase	phhA	0.0058
68	Cannabinoid receptor 1	CNR1	0.0058
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0058
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0057
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0057
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0057
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0057
1629	Transcription factor AP-1	JUN	0.0056
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0056
357	Carbonic anhydrase 2	CA2	0.0056
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0055
284	DNA-directed RNA polymerase beta chain	rpoB	0.0055
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0055
459	Retinoic acid receptor RXR-alpha	RXRA	0.0055
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0055
6506	Stathmin-4	STMN4	0.0055
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0053
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0053
295	Carbonic anhydrase 1	CA1	0.0053
594	Thyroxine-binding globulin	SERPINA7	0.0053
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0053
2852	DNA mismatch repair protein mutL	mutL	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
444	Alcohol dehydrogenase 1B	ADH1B	0.0052
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0052
49	Endothelin B receptor	EDNRB	0.0052
814	Ryanodine receptor 1	RYR1	0.0052
708	Alpha-tocopherol transfer protein	TTPA	0.0052
4077	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	PPP2CB	0.0052
712	Tubulin alpha chain	TUB1	0.0052
86	SEC14-like protein 4	SEC14L4	0.0052
375	SEC14-like protein 3	SEC14L3	0.0052
4076	Diacylglycerol kinase alpha	DGKA	0.0052
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0052
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0052
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0051
65	Matrix metalloproteinase-9	Not Available	0.0051
3221	Cytochrome c4	cc4	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
4078	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	PPP2CA	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
997	Protein kinase C beta type	PRKCB	0.005
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.005
4103	Proteasome subunit beta type 2	PSMB2	0.005
4102	Proteasome subunit beta type 5	PSMB5	0.005
4101	Proteasome subunit beta type 1	PSMB1	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0049
578	Endothelin-1 receptor	EDNRA	0.0049
758	Thyroid hormone receptor alpha	THRA	0.0049
3191	Histidinol dehydrogenase	hisD	0.0049
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0049
6044	Serum paraoxonase/lactonase 3	PON3	0.0049
6149	Solute carrier family 22 member 10	SLC22A10	0.0048
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
164	Histamine H4 receptor	HRH4	0.0048
239	Coagulation factor X	F10	0.0048
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0048
5787	Angiopoietin-1 receptor	TEK	0.0047
856	Vitamin D3 receptor	VDR	0.0047
5300	Antigen peptide transporter 1	TAP1	0.0047
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0047
683	Potassium transporter	GK0582	0.0047
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0046
780	Retinoic acid receptor RXR-gamma	RXRG	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0046
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0046
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0045
1970	Protein kinase C alpha type	PRKCA	0.0045
6316	ADP-ribosylation factor 1	ARF1	0.0045
4692	A/G-specific adenine glycosylase	mutY	0.0045
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0044
346	Thyroid hormone receptor beta-1	THRB	0.0044
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
887	DNA gyrase subunit B	gyrB	0.0044
4150	DNA gyrase subunit B	gyrB	0.0044
6225	DNA gyrase subunit B	gyrB	0.0044
707	72 kDa type IV collagenase	MMP2	0.0044
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0043
518	Peroxidase/catalase T	katG	0.0043
810	Heme oxygenase 1	HMOX1	0.0043
3391	Heme oxygenase 1	pbsA1	0.0043
24	Thymidylate synthase	TMP1	0.0043
359	Thymidylate synthase	TYMS	0.0043
2626	Thymidylate synthase	thyA	0.0043
2729	Thymidylate synthase	thyA	0.0043
5352	Thymidylate synthase	THYA	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
6151	Monocarboxylate transporter 10	SLC16A10	0.0043
823	Fibroblast growth factor receptor 2	FGFR2	0.0043
88	Retinoic acid receptor RXR-beta	RXRB	0.0043
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.0043
2802	Endoglucanase G	celCCG	0.0042
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0042
1852	Microtubule-associated protein 2	MAP2	0.0042
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0042
33	Cystine/glutamate transporter	SLC7A11	0.0041
165	FL cytokine receptor	FLT3	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
5934	Cytochrome P450 26A1	CYP26A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.004
4161	Furin	FURIN	0.004
4203	Histamine N-methyltransferase	HNMT	0.004
1992	Vitamin D-binding protein	GC	0.004
1714	Mitogen-activated protein kinase 3	MAPK3	0.004
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.004
3856	Fibroblast growth factor receptor 3	FGFR3	0.0039
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0039
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
563	Thyroid peroxidase	TPO	0.0038
6067	Penicillin binding protein 2a	mecA	0.0038
3957	Adenosine deaminase	ADA	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0038
233	Potassium channel subfamily K member 2	KCNK2	0.0038
85	Growth hormone receptor	GHR	0.0038
992	Protein tyrosine kinase 2 beta	PTK2B	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
634	Squalene monooxygenase	SQLE	0.0036
7196	Squalene monooxygenase	ERG1	0.0036
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
5448	Ribonuclease Z	rnz	0.0035
5449	Hypothetical gliding protein	mglB	0.0035
3781	Thiol:disulfide interchange protein dsbC precursor	dsbC	0.0035
4705	Manganese catalase	Not Available	0.0035
5439	33 kDa chaperonin	hslO	0.0035
5443	UPF0189 protein ymdB	ymdB	0.0035
5446	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase	HI_1679	0.0035
5440	UPF0067 protein yebR	yebR	0.0035
4210	Toll-like receptor 4	TLR4	0.0035
2720	Copper-containing nitrite reductase	nirK	0.0035
5454	Internalin-A	inlA	0.0035
5447	Lethal(3)malignant brain tumor-like protein	L3MBTL1	0.0035
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0035
2300	Lysozyme	E	0.0035
3633	Lysozyme	R	0.0035
5597	Lysozyme	17	0.0035
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
229	Retinoic acid receptor beta	RARB	0.0034
6766	O-GlcNAcase BT_4395	BT_4395	0.0034
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0034
4498	Ornithine cyclodeaminase	PP3533	0.0034
6126	Carbonic anhydrase 7	CA7	0.0034
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0034
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0034
730	Retinoic acid receptor alpha	RARA	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1864	RET proto-oncogene	RET	0.0033
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0033
976	Platelet glycoprotein IX	GP9	0.0033
162	Retinoic acid receptor gamma-1	RARG	0.0033
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0033
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0033
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0033
1483	Membrane copper amine oxidase	AOC3	0.0033
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0032
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0032
1867	Major prion protein	PRNP	0.0032
1291	cAMP response element-binding protein	CREB1	0.0032
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
581	Cytochrome P450 2R1	CYP2R1	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
199	Monocarboxylate transporter 8	SLC16A2	0.0031
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0031
5450	Prolyl endopeptidase Pep	pep	0.0031
4771	Dissimilatory copper-containing nitrite reductase	nir	0.0031
3356	Diaminopimelate decarboxylase	lysA	0.0031
2714	Chorismate mutase	aroH	0.0031
4611	Chorismate mutase	aroG	0.0031
3274	Hydroxylamine reductase	hcp	0.0031
4804	Hydroxylamine reductase	hcp	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
6824	Tyrosine-protein kinase Lyn	LYN	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
4217	Telomerase reverse transcriptase	TERT	0.003
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.003
106	Cannabinoid receptor 2	CNR2	0.003
6174	50S ribosomal protein L32	rpmF	0.0029
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0029
6103	Arylamine N-acetyltransferase 1	NAT1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
4608	Putative cytochrome P450	SCO1207	0.0029
4963	Putative cytochrome P450	SCO2884	0.0029
6254	Putative cytochrome P450	SCO6998	0.0029
4773	Deoxycytidine kinase	DCK	0.0029
3810	Catechol O-methyltransferase	COMT	0.0029
3399	Limonene-1,2-epoxide hydrolase	limA	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
3462	Tyrosine-protein kinase transforming protein Abl	ABL	0.0028
3697	Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase	glmU	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
597	Dihydropteridine reductase	QDPR	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
3937	Fatty-acid amide hydrolase	FAAH	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
7	Nitric oxide synthase, inducible	NOS2	0.0028
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0027
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
5180	L(+)-mandelate dehydrogenase	mdlB	0.0027
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0027
3500	Putative family 31 glucosidase yicI	yicI	0.0027
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
144	Hemoglobin subunit alpha	HBA1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
577	Argininosuccinate lyase	ASL	0.0026
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0026
936	Ephrin type-A receptor 2	EPHA2	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
1648	Elastin	ELN	0.0026
2207	Rhodopsin	RHO	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
1615	Chymase	CMA1	0.0026
469	Annexin A1	ANXA1	0.0026
1630	Integrin beta-2	ITGB2	0.0025
6859	Protein S100-A4	S100A4	0.0025
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0025
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0025
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0025
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0025
153	Dopamine beta-hydroxylase	DBH	0.0024
1374	Natriuretic peptides B	NPPB	0.0024
1827	Gap junction alpha-1 protein	GJA1	0.0024
1908	Vascular cell adhesion protein 1	VCAM1	0.0024
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
4035	Glutathione S-transferase Mu 5	GSTM5	0.0024
900	Glutathione S-transferase A4	GSTA4	0.0024
903	Glutathione S-transferase A5	GSTA5	0.0024
4037	Hypothetical protein	GPX1	0.0024
4297	Hypothetical protein	SP_1951	0.0024
4521	Hypothetical protein	BC_2969	0.0024
4540	Hypothetical protein	TM_1070	0.0024
4555	Hypothetical protein	MT1739	0.0024
4569	Hypothetical protein	mshD	0.0024
4578	Hypothetical protein	PA3270	0.0024
4747	Hypothetical protein	PA3967	0.0024
5177	Hypothetical protein	TM_0096	0.0024
5194	Hypothetical protein	PA1204	0.0024
5240	Hypothetical protein	Rv2991	0.0024
5370	Hypothetical protein	TM_1158	0.0024
5710	Hypothetical protein	Tb927.5.1360	0.0024
1928	Leukotriene C4 synthase	LTC4S	0.0024
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0024
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0024
4034	Glutaredoxin-1	GLRX	0.0024
906	Glutathione peroxidase 1	GPX1	0.0024
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0024
4036	Glutathione peroxidase 6	GPX6	0.0024
911	Glutathione peroxidase 3	GPX3	0.0024
2320	Thymidine kinase, cytosolic	TK1	0.0024
4042	Glutathione transferase omega-2	GSTO2	0.0024
4029	Microsomal glutathione S-transferase 3	MGST3	0.0024
4032	Microsomal glutathione S-transferase 1	MGST1	0.0024
910	Epididymal secretory glutathione peroxidase	GPX5	0.0024
4033	S-formylglutathione hydrolase	ESD	0.0024
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0024
4040	Glutathione peroxidase 7	GPX7	0.0024
907	Glutathione peroxidase 2	GPX2	0.0024
4038	Glutathione peroxidase 4	GPX4	0.0024
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0024
6231	Pepsin A	PGA3	0.0024
287	Beta-1,4-galactosyltransferase 1	B4GALT1	0.0024
6070	Nischarin	NISCH	0.0024
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
898	Glutathione S-transferase A3	GSTA3	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
897	Glutathione S-transferase kappa 1	GSTK1	0.0023
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0023
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0023
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0023
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0023
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0023
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0023
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0023
909	Maleylacetoacetate isomerase	GSTZ1	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
1262	Corticotropin-lipotropin	POMC	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
54	Prothrombin	F2	0.0022
2021	Thrombomodulin	THBD	0.0022
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0022
3404	Exotoxin A	eta	0.0022
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
298	Renin	REN	0.0021
2091	Endoplasmin	HSP90B1	0.0021
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0021
6211	Tubulin epsilon chain	TUBE1	0.0021
6212	Tubulin gamma-1 chain	TUBG1	0.0021
6210	Tubulin delta chain	TUBD1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0021
2165	Glutathione S-transferase Mu 2	GSTM2	0.0021
6218	Pannexin-1	PANX1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0021
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.002
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
1820	Beta-nerve growth factor	NGF	0.002
6755	Poliovirus receptor	PVR	0.002
3809	Estrogen-related receptor gamma	ESRRG	0.002
822	Aldose reductase	AKR1B1	0.002
572	Integrin alpha-L	ITGAL	0.0019
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0019
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
4226	Uridine phosphorylase 2	UPP2	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
1196	Complement decay-accelerating factor	CD55	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0019
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0019
207	Glutathione synthetase	GSS	0.0019
5269	Glutathione synthetase	gshB	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
291	Nitric-oxide synthase, endothelial	NOS3	0.0018
5626	Nucleoside diphosphate kinase B	NME2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
5923	Microtubule-associated protein tau	MAPT	0.0018
5924	Microtubule-associated protein 4	MAP4	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
251	Alcohol dehydrogenase 1A	ADH1A	0.0018
4225	Uridine phosphorylase 1	UPP1	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0018
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
84	Nuclear receptor 0B1	NR0B1	0.0017
489	Monocarboxylate transporter 2	SLC16A7	0.0017
3830	Calreticulin	CALR	0.0017
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0017
1275	Estrogen sulfotransferase	SULT1E1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
484	Tyrosine-protein kinase ABL2	ABL2	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0017
760	Fibroblast growth factor 1	FGF1	0.0017
820	Glycine receptor subunit alpha-2	GLRA2	0.0017
413	Amidophosphoribosyltransferase	PPAT	0.0017
2515	Amidophosphoribosyltransferase	purF	0.0017
3714	Amidophosphoribosyltransferase	purF	0.0017
2808	Chloramphenicol acetyltransferase 3	cat3	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
2216	Fibroblast growth factor receptor 4	FGFR4	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
6042	Prostaglandin reductase 2	PTGR2	0.0016
6228	Nuclear receptor coactivator 1	NCOA1	0.0016
1243	Cathepsin D	CTSD	0.0016
751	Potassium channel subfamily K member 6	KCNK6	0.0016
517	Alcohol dehydrogenase 1C	ADH1C	0.0016
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
1268	Neuropeptide S receptor	NPSR1	0.0016
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0016
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0016
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
3233	Bile acid receptor	NR1H4	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
1792	Tissue-type plasminogen activator	PLAT	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3601	Dihydropteroate synthase 1	folP1	0.0015
3807	Dihydropteroate synthase 1	folP1	0.0015
3808	Dihydropteroate synthase 2	folP2	0.0015
2417	Chloramphenicol acetyltransferase	cat	0.0015
3278	Chloramphenicol acetyltransferase	cat	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
268	Adenosine A2b receptor	ADORA2B	0.0015
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0015
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0015
2810	Dr hemagglutinin structural subunit	draA	0.0015
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
6048	Troponin C, skeletal muscle	TNNC2	0.0015
172	Potassium channel subfamily K member 1	KCNK1	0.0015
5294	Nucleoside diphosphate kinase A	NME1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
5798	Mitogen-activated protein kinase 11	MAPK11	0.0014
1541	Metalloproteinase	mmp20	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
6073	Potassium channel subfamily K member 9	KCNK9	0.0014
6072	Potassium channel subfamily K member 3	KCNK3	0.0014
3913	Glutamic acid decarboxylase	GAD65	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
3639	Thymidine phosphorylase	deoA	0.0014
3936	Thymidine phosphorylase	TYMP	0.0014
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0013
6241	Nuclear receptor coactivator 2	NCOA2	0.0013
1039	Histone deacetylase 9	HDAC9	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1295	Fatty acid synthase	FASN	0.0012
735	Alanine aminotransferase 1	GPT	0.0012
3904	Alanine aminotransferase 2	GPT2	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0011
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0009
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0009
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0009
6168	Solute carrier family 22 member 16	SLC22A16	0.0009
267	Plasminogen activator inhibitor 1	SERPINE1	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
1650	Heme carrier protein 1	SLC46A1	0.0009
2132	Protein S100-B	S100B	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
6221	Steroid hormone receptor ERR1	ESRRA	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
2298	Cytochrome P450-cam	camC	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
76	Nitric-oxide synthase, brain	NOS1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
798	Osteocalcin	BGLAP	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
5961	Insulin	INS	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
6524	Protein tonB	tonB	0.0004
4943	Cytochrome c6	petJ	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
5000	HemO	hemO	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4961	Hemophore HasA	hasA	0.0004
4909	CooA protein	cooA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4972	P450cin	cinA	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4952	Catalase/peroxidase	katA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
4920	Peroxidase/catalase	katG	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
2230	Catalase	CAT	0.0003
3249	Catalase	katA	0.0003
3625	Catalase	katA	0.0003
4539	Catalase	katA	0.0003
4941	Catalase	katB	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01242 - Clomipramine

Targets

Enzymes

Transporters

Carriers

Predictions