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Complement C3


Partner ID 5898
Name Complement C3
Synonyms 7692
Gene name C3
General function Not Available
Specific function Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes
Gene sequence + ...

Not Available
Protein sequence + ...

MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN
GO Classification
component
extracellular region
function
enzyme regulator activity
enzyme inhibitor activity
protease inhibitor activity
endopeptidase inhibitor activity
process
humoral immune response
complement activation
inflammatory response
response to stimulus
response to biotic stimulus
defense response
immune response
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB00028 Intravenous Immunoglobulin
DB01915 S-Hydroxycysteine

Associated as Prediction

Id Name
DB00002 Cetuximab
DB00005 Etanercept
DB00028 Intravenous Immunoglobulin
DB00051 Adalimumab
DB00054 Abciximab
DB00056 Gemtuzumab ozogamicin
DB00072 Trastuzumab
DB00073 Rituximab
DB00074 Basiliximab
DB00075 Muromonab
DB00078 Ibritumomab
DB00081 Tositumomab
DB00087 Alemtuzumab
DB00092 Alefacept
DB00095 Efalizumab
DB00098 Antithymocyte globulin
DB00108 Natalizumab
DB00110 Palivizumab
DB00111 Daclizumab
DB00112 Bevacizumab
DB00143 Glutathione
DB00163 Vitamin E
DB00291 Chlorambucil
DB00515 Cisplatin
DB00526 Oxaliplatin
DB00707 Porfimer
DB00773 Etoposide
DB00958 Carboplatin
DB00992 Methyl aminolevulinate
DB00993 Azathioprine
DB01008 Busulfan
DB01242 Clomipramine
DB01257 Eculizumab
DB01805 Monoisopropylphosphorylserine
DB01834 (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene
DB01915 S-Hydroxycysteine
DB01992 Coenzyme A
DB02003 Delta-Bis(2,2'-Bipyridine)Imidazole Ruthenium (Ii)
DB02039 S-Acetyl-Cysteine
DB02160 S-Butyryl-Cystein
DB02442 Dioxyselenocysteine
DB02486 2-Hydroxyethyl Disulfide
DB02586 4,7-Dimethyl-[1,10]Phenanthroline
DB02633 Cibacron Blue
DB02943 N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine
DB03003 Glutathione Sulfonic Acid
DB03045 Pantothenyl-Aminoethanol-Acetate Pivalic Acid
DB03059 Acetoacetyl-Coenzyme A
DB03297 Benzylsulfinic Acid
DB03492 Lambda-Bis(2,2'-Bipyridine)Imidazole Osmium (Ii)
DB03570 Tris-Hydroxymethyl-Methyl-Ammonium
DB03602 S-Benzyl-Glutathione
DB03686 S-(P-Nitrobenzyl)Glutathione
DB03796 Palmitic Acid
DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
DB03840 Tetra(Imidazole)Diaquacopper (Ii)
DB03871 Lambda-Bis(2,2'-Bipyridine)Imidazole Ruthenium (Ii)
DB04077 Glycerol
DB04085 1-[Pyrrol-1-Yl-2,5-Dione-Methoxymethyl]-Pyrrole-2,5-Dione
DB04100 (1,10 Phenanthroline)-(Tri-Carbon Monoxide) Rhenium (I)
DB04132 S-Hexylglutathione
DB04147 Lauryl Dimethylamine-N-Oxide
DB04224 Oleic Acid
DB04231 Tetra(Imidazole)Diaquacopper (I)
DB04339 Carboxymethylenecysteine
DB04491 Diisopropylphosphono Group
DB04550 Delta-Bis(2,2'-Bipyridine)Imidazole Osmium (Ii)
DB06968 1,1'-HEXANE-1,6-DIYLBIS(1H-IMIDAZOLE)
DB07849 S-NONYL-CYSTEINE
DB08328 PANTOTHENYL-AMINOETHANOL-11-PIVALIC ACID
DB08370 S-(4-BROMOBENZYL)CYSTEINE
DB08408 (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl 2,2-dimethylpropanoate
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