Identification | |||||
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Name | Ibritumomab | ||||
Accession Number | DB00078 (BIOD00069, BTD00069) | ||||
Type | biotech | ||||
Description | Indium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light chains of 213 amino acids each. | ||||
Structure |
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Categories (*) | |||||
Molecular Weight | 143375.5000 | ||||
Groups | approved | ||||
Monoisotopic Weight | Not Available | ||||
Pharmacology | |||||
Indication | For treatment of non-Hodgkin's lymphoma | ||||
Mechanism of action | The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles. | ||||
Absorption | Not Available | ||||
Protein binding | Not Available | ||||
Biotransformation | Most likely removed by opsonization via the reticuloendothelial system when bound to B cells, or by human antimurine antibody production | ||||
Route of elimination | Not Available | ||||
Toxicity | Not Available | ||||
Affected organisms |
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Interactions | |||||
Drug Interactions |
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Food Interactions | Not Available |
B-lymphocyte antigen CD20 | |
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Name | B-lymphocyte antigen CD20 |
Gene Name | MS4A1 |
Pharmacological action | yes |
Actions | antibody |
References |
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DTHybrid score | 0.5397 |
Low affinity immunoglobulin gamma Fc region receptor III-B | |
Name | Low affinity immunoglobulin gamma Fc region receptor III-B |
Gene Name | FCGR3B |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.655 |
Complement C1r subcomponent | |
Name | Complement C1r subcomponent |
Gene Name | C1R |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5628 |
Complement C1q subcomponent subunit A | |
Name | Complement C1q subcomponent subunit A |
Gene Name | C1QA |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5811 |
Complement C1q subcomponent subunit B | |
Name | Complement C1q subcomponent subunit B |
Gene Name | C1QB |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.582 |
Complement C1q subcomponent subunit C | |
Name | Complement C1q subcomponent subunit C |
Gene Name | C1QC |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.582 |
Low affinity immunoglobulin gamma Fc region receptor III-A | |
Name | Low affinity immunoglobulin gamma Fc region receptor III-A |
Gene Name | FCGR3A |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.6546 |
Complement C1s subcomponent | |
Name | Complement C1s subcomponent |
Gene Name | C1S |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.1652 |
High affinity immunoglobulin gamma Fc receptor I | |
Name | High affinity immunoglobulin gamma Fc receptor I |
Gene Name | FCGR1A |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.7397 |
Low affinity immunoglobulin gamma Fc region receptor II-a | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-a |
Gene Name | FCGR2A |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.6632 |
Low affinity immunoglobulin gamma Fc region receptor II-b | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-b |
Gene Name | FCGR2B |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.6578 |
Low affinity immunoglobulin gamma Fc region receptor II-c | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-c |
Gene Name | FCGR2C |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.6689 |