DT-Web

DB01834 - (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene


Identification
Name (9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-Dihydrophenanthrene
Accession Number DB01834 (EXPT01641)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 501.552
Groups experimental
Monoisotopic Weight 501.156970923
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glutathione S-transferase P
Name Glutathione S-transferase P
Gene Name GSTP1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6074
Glutathione S-transferase Mu 1
Name Glutathione S-transferase Mu 1
Gene Name GSTM1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6128

Predictions


Id Partner name Gene Name Score
4031 Glutathione S-transferase A1 GSTA1 0.1018
2165 Glutathione S-transferase Mu 2 GSTM2 0.0895
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0656
2314 Triosephosphate isomerase TPI 0.0595
3417 Triosephosphate isomerase tpiA 0.0595
3443 Triosephosphate isomerase tpiA 0.0595
6346 Triosephosphate isomerase TPI1 0.0595
3932 Glutathione S-transferase A2 GSTA2 0.0543
901 Glutathione S-transferase Mu 4 GSTM4 0.0452
4041 Microsomal glutathione S-transferase 2 MGST2 0.0442
908 Glutathione S-transferase theta-1 GSTT1 0.0409
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0382
6163 Copper-transporting ATPase 2 ATP7B 0.0358
6165 Copper-transporting ATPase 1 ATP7A 0.0358
6146 High affinity copper uptake protein 1 SLC31A1 0.0339
3759 Glutathione S-transferase gst 0.0325
4541 Glutathione S-transferase GST 0.0325
3947 Xanthine dehydrogenase/oxidase XDH 0.0319
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0266
1757 Myeloperoxidase MPO 0.026
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0239
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0224
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0216
1313 Lactoylglutathione lyase GLO1 0.0208
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0193
1405 Thiopurine S-methyltransferase TPMT 0.0181
4512 Cytochrome P450 3A4 CYP3A4 0.0162
5898 Complement C3 C3 0.0154
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0139
6677 Myelin P2 protein PMP2 0.0122
2517 Subtilisin BPN' apr 0.0116
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0115
6144 Solute carrier family 22 member 2 SLC22A2 0.0112
2596 Acetyl-CoA acetyltransferase phbA 0.0105
899 Glutathione S-transferase Mu 3 GSTM3 0.0102
6137 Multidrug resistance-associated protein 6 ABCC6 0.01
905 Glutathione transferase omega-1 GSTO1 0.0099
6136 Multidrug resistance-associated protein 5 ABCC5 0.0097
2443 Azurin azu 0.0097
1588 Multidrug resistance protein 1 ABCB1 0.0094
6013 Cytochrome P450 2E1 CYP2E1 0.0092
4200 Cytochrome P450 1A2 CYP1A2 0.0092
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0078
290 Prostaglandin G/H synthase 2 PTGS2 0.0073
6147 Solute carrier family 22 member 3 SLC22A3 0.0072
1898 Cytochrome P450 1B1 CYP1B1 0.0071
4035 Glutathione S-transferase Mu 5 GSTM5 0.0069
468 Cytochrome P450 4A11 CYP4A11 0.0069
3923 Cholinesterase BCHE 0.0064
900 Glutathione S-transferase A4 GSTA4 0.0063
1928 Leukotriene C4 synthase LTC4S 0.0063
903 Glutathione S-transferase A5 GSTA5 0.0063
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0063
4034 Glutaredoxin-1 GLRX 0.0062
4037 Hypothetical protein GPX1 0.0062
4297 Hypothetical protein SP_1951 0.0062
4521 Hypothetical protein BC_2969 0.0062
4540 Hypothetical protein TM_1070 0.0062
4555 Hypothetical protein MT1739 0.0062
4569 Hypothetical protein mshD 0.0062
4578 Hypothetical protein PA3270 0.0062
4747 Hypothetical protein PA3967 0.0062
5177 Hypothetical protein TM_0096 0.0062
5194 Hypothetical protein PA1204 0.0062
5240 Hypothetical protein Rv2991 0.0062
5370 Hypothetical protein TM_1158 0.0062
5710 Hypothetical protein Tb927.5.1360 0.0062
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0062
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0062
4036 Glutathione peroxidase 6 GPX6 0.0062
4040 Glutathione peroxidase 7 GPX7 0.0062
4029 Microsomal glutathione S-transferase 3 MGST3 0.0062
4032 Microsomal glutathione S-transferase 1 MGST1 0.0062
906 Glutathione peroxidase 1 GPX1 0.0062
4033 S-formylglutathione hydrolase ESD 0.0062
911 Glutathione peroxidase 3 GPX3 0.0062
907 Glutathione peroxidase 2 GPX2 0.0062
4042 Glutathione transferase omega-2 GSTO2 0.0062
910 Epididymal secretory glutathione peroxidase GPX5 0.0062
4038 Glutathione peroxidase 4 GPX4 0.0062
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0062
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0062
6145 Solute carrier family 22 member 1 SLC22A1 0.0061
6432 Transporter snf 0.0061
897 Glutathione S-transferase kappa 1 GSTK1 0.0059
898 Glutathione S-transferase A3 GSTA3 0.0059
3319 Hydroxyacylglutathione hydrolase HAGH 0.0059
909 Maleylacetoacetate isomerase GSTZ1 0.0058
6024 Cytochrome P450 1A1 CYP1A1 0.0058
3709 Glycerol uptake facilitator protein glpF 0.0055
3116 Bacterioferritin bfr 0.0055
4906 Bacterioferritin bfr 0.0055
4965 Bacterioferritin bfr 0.0055
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0055
3173 Enolase eno 0.0055
3393 TGF-beta receptor type-2 TGFBR2 0.0055
3238 Multidrug resistance protein mexA mexA 0.0055
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0055
708 Alpha-tocopherol transfer protein TTPA 0.0052
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0052
86 SEC14-like protein 4 SEC14L4 0.0052
283 SEC14-like protein 2 SEC14L2 0.0052
375 SEC14-like protein 3 SEC14L3 0.0052
4076 Diacylglycerol kinase alpha DGKA 0.0052
862 Multidrug resistance-associated protein 1 ABCC1 0.005
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.005
997 Protein kinase C beta type PRKCB 0.005
2852 DNA mismatch repair protein mutL mutL 0.0048
207 Glutathione synthetase GSS 0.0048
5269 Glutathione synthetase gshB 0.0048
1970 Protein kinase C alpha type PRKCA 0.0045
6459 Glycodelin PAEP 0.0045
3191 Histidinol dehydrogenase hisD 0.0044
3221 Cytochrome c4 cc4 0.0044
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0044
6030 Cytochrome P450 2B6 CYP2B6 0.0044
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0043
436 5-hydroxytryptamine 2B receptor HTR2B 0.0042
740 Argininosuccinate synthase ASS1 0.0041
865 Argininosuccinate synthase ASS1 0.0041
2680 Argininosuccinate synthase argG 0.0041
3194 Argininosuccinate synthase argG 0.0041
810 Heme oxygenase 1 HMOX1 0.0041
3391 Heme oxygenase 1 pbsA1 0.0041
4192 DNA topoisomerase 2-beta TOP2B 0.0041
714 Glutathione reductase, mitochondrial GSR 0.0041
4311 tRNA TRDMT1 0.0041
4325 tRNA trmD 0.0041
4328 tRNA trmD 0.0041
4692 A/G-specific adenine glycosylase mutY 0.004
2802 Endoglucanase G celCCG 0.0039
6316 ADP-ribosylation factor 1 ARF1 0.0038
590 5-hydroxytryptamine 2C receptor HTR2C 0.0037
824 Sodium-dependent serotonin transporter SLC6A4 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
4757 Cytochrome P450 2C9 CYP2C9 0.0037
5448 Ribonuclease Z rnz 0.0035
5449 Hypothetical gliding protein mglB 0.0035
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0035
4705 Manganese catalase Not Available 0.0035
5439 33 kDa chaperonin hslO 0.0035
332 Beta-lactamase blaZ 0.0035
2478 Beta-lactamase ampC 0.0035
2613 Beta-lactamase ampC 0.0035
2635 Beta-lactamase ampC 0.0035
2700 Beta-lactamase penP 0.0035
5445 Beta-lactamase blaB 0.0035
6019 Beta-lactamase SHV-7 0.0035
6701 Beta-lactamase cphA 0.0035
5443 UPF0189 protein ymdB ymdB 0.0035
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0035
5440 UPF0067 protein yebR yebR 0.0035
2720 Copper-containing nitrite reductase nirK 0.0035
5454 Internalin-A inlA 0.0035
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0035
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0035
4498 Ornithine cyclodeaminase PP3533 0.0034
502 5-hydroxytryptamine 2A receptor HTR2A 0.0033
444 Alcohol dehydrogenase 1B ADH1B 0.0033
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0032
275 Arachidonate 5-lipoxygenase ALOX5 0.0032
5450 Prolyl endopeptidase Pep pep 0.0031
4771 Dissimilatory copper-containing nitrite reductase nir 0.0031
3356 Diaminopimelate decarboxylase lysA 0.0031
2714 Chorismate mutase aroH 0.0031
4611 Chorismate mutase aroG 0.0031
3274 Hydroxylamine reductase hcp 0.0031
4804 Hydroxylamine reductase hcp 0.0031
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.003
587 Serum albumin ALB 0.003
6148 Multidrug resistance-associated protein 7 ABCC10 0.003
3399 Limonene-1,2-epoxide hydrolase limA 0.0029
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
597 Dihydropteridine reductase QDPR 0.0028
817 DNA topoisomerase 2-alpha TOP2A 0.0028
2164 Multidrug resistance-associated protein 4 ABCC4 0.0027
5180 L(+)-mandelate dehydrogenase mdlB 0.0027
3500 Putative family 31 glucosidase yicI yicI 0.0027
4608 Putative cytochrome P450 SCO1207 0.0027
4963 Putative cytochrome P450 SCO2884 0.0027
6254 Putative cytochrome P450 SCO6998 0.0027
3480 Mannan endo-1,4-beta-mannosidase manA 0.0027
577 Argininosuccinate lyase ASL 0.0026
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0026
6016 Cytochrome P450 2C19 CYP2C19 0.0026
1615 Chymase CMA1 0.0026
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0025
4119 Cytochrome P450 2D6 CYP2D6 0.0025
365 Dihydrofolate reductase DHFR 0.0024
2381 Dihydrofolate reductase DFR1 0.0024
2833 Dihydrofolate reductase Not Available 0.0024
2931 Dihydrofolate reductase folA 0.0024
3544 Dihydrofolate reductase folA 0.0024
3682 Dihydrofolate reductase folA 0.0024
6642 Dihydrofolate reductase folA 0.0024
6756 Dihydrofolate reductase dfrA 0.0024
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0024
20 Prostaglandin G/H synthase 1 PTGS1 0.0022
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
4118 Cytochrome P450 3A5 CYP3A5 0.0019
4924 Cytochrome P450 2C8 CYP2C8 0.0019
474 Acetylcholinesterase ACHE 0.0015
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