Identification | |||||||
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Name | Alefacept | ||||||
Accession Number | DB00092 (BIOD00055, BTD00055) | ||||||
Type | biotech | ||||||
Description | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | ||||||
Structure |
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Categories (*) | |||||||
Molecular Weight | 51801.1000 | ||||||
Groups | approved | ||||||
Monoisotopic Weight | Not Available | ||||||
Pharmacology | |||||||
Indication | As an immunosuppressive drug, Alefacept can be used for treatment of moderate to severe chronic plaque psoriasis | ||||||
Mechanism of action | Inhibits T-lymphocyte activation and production by binding to the CD2 lymphocyte antigen. | ||||||
Absorption | Not Available | ||||||
Protein binding | Not Available | ||||||
Biotransformation | Not Available | ||||||
Route of elimination | Not Available | ||||||
Toxicity | Not Available | ||||||
Affected organisms |
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Interactions | |||||||
Drug Interactions |
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Food Interactions | Not Available |
T-cell surface antigen CD2 | |
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Name | T-cell surface antigen CD2 |
Gene Name | CD2 |
Pharmacological action | yes |
Actions | inhibitor |
References |
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DTHybrid score | 0.2363 |
Complement C1r subcomponent | |
Name | Complement C1r subcomponent |
Gene Name | C1R |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.4125 |
Complement C1q subcomponent subunit A | |
Name | Complement C1q subcomponent subunit A |
Gene Name | C1QA |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.4208 |
Complement C1q subcomponent subunit B | |
Name | Complement C1q subcomponent subunit B |
Gene Name | C1QB |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.4217 |
Complement C1q subcomponent subunit C | |
Name | Complement C1q subcomponent subunit C |
Gene Name | C1QC |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.4217 |
Low affinity immunoglobulin gamma Fc region receptor III-A | |
Name | Low affinity immunoglobulin gamma Fc region receptor III-A |
Gene Name | FCGR3A |
Pharmacological action | unknown |
Actions | Not Available |
References |
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DTHybrid score | 1.496 |
High affinity immunoglobulin gamma Fc receptor I | |
Name | High affinity immunoglobulin gamma Fc receptor I |
Gene Name | FCGR1A |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5847 |
Low affinity immunoglobulin gamma Fc region receptor II-a | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-a |
Gene Name | FCGR2A |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5047 |
Low affinity immunoglobulin gamma Fc region receptor II-b | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-b |
Gene Name | FCGR2B |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5009 |
Low affinity immunoglobulin gamma Fc region receptor II-c | |
Name | Low affinity immunoglobulin gamma Fc region receptor II-c |
Gene Name | FCGR2C |
Pharmacological action | unknown |
Actions | Not Available |
References | |
DTHybrid score | 1.5103 |
Low affinity immunoglobulin gamma Fc region receptor III-B | |
Name | Low affinity immunoglobulin gamma Fc region receptor III-B |
Gene Name | FCGR3B |
Pharmacological action | unknown |
Actions | Not Available |
References |
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DTHybrid score | 1.4964 |