DT-Web

DB00526 - Oxaliplatin


Identification
Name Oxaliplatin
Accession Number DB00526 (APRD00186)
Type small molecule
Description Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. It is typically administered in combination with fluorouracil and leucovorin in a combination known as Folfox for the treatment of colorectal cancer. Compared to cisplatin the two amine groups are replaced by cyclohexyldiamine for improved antitumour activity. The chlorine ligands are replaced by the oxalato bidentate derived from oxalic acid in order to improve water solubility. Oxaliplatin is marketed by Sanofi-Aventis under the trademark Eloxatin®.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 395.276
Groups approved
Monoisotopic Weight 395.044481331
Pharmacology
Indication Used in combination with infusional 5-FU/LV, is indicated for the treatment of advanced carcinoma of the colon or rectum and for adjuvant treatment of stage III colon cancer patients who have undergone complete resection of the primary tumor.
Mechanism of action Oxaliplatin undergoes nonenzymatic conversion to active derivatives via displacement of the labile oxalate ligand. Several transient reactive species are formed, including monoaquo and diaquo DACH platinum, which covalently bind with macromolecules. After activation, oxaliplatin binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and transcription. Cytotoxicity is cell-cycle nonspecific.
Absorption Bioavailability is complete following intravenous administration. When a single 2-hour intravenous infusion of oxaliplatin at a dose of 85 mg/m^2 is given, the peak serum concentration was 0.814 mcg/mL.
Protein binding Plasma protein binding of platinum (active metabolite) is irreversible and is greater than 90%, primarily to albumin and gamma-globulins. It is also irreversibly binds to erythrocytes.
Biotransformation Oxaliplatin undergoes nonenzymatic conversion in physiologic solutions to active derivatives via displacement of the labile oxalate ligand. Several transient reactive species are formed, including monoaquo and diaquo DACH platinum, which covalently bind with macromolecules. There is no evidence of cytochrome P450-mediated metabolism in vitro.
Route of elimination The major route of platinum elimination is renal excretion. At five days after a single 2-hour infusion of oxaliplatin, urinary elimination accounted for about 54% of the platinum eliminated, with fecal excretion accounting for only about 2%.
Toxicity There have been five cases of oxaliplatin overdose reported. One patient received two 130 mg/m2 doses of oxaliplatin (cumulative dose of 260 mg/m2) within a 24-hour period. The patient experienced Grade 4 thrombocytopenia (<25,000/mm3) without any bleeding, which resolved. Two other patients were mistakenly administered oxaliplatin instead of carboplatin. One patient received a total oxaliplatin dose of 500 mg and the other received 650 mg. The first patient experienced dyspnea, wheezing, paresthesia, profuse vomiting and chest pain on the day of administration. She developed respiratory failure and severe bradycardia, and subsequently did not respond to resuscitation efforts. The other patient also experienced dyspnea, wheezing, paresthesia, and vomiting. Most common adverse reactions (incidence >= 40%) were peripheral sensory neuropathy, neutropenia, thrombocytopenia, anemia, nausea, increase in transaminases and alkaline phosphatase, diarrhea, emesis, fatigue and stomatitis.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bendamustine Increases toxicity through pharmacodynamic synergism. Additive myelosuppression.
Topotecan Administration of Topotecan after Oxaliplatin therapy may increase the risk of hematologic toxicity, such as neutropenia and/or thrombocytopenia. A dose adjustment may be required or the sequence of administration reversed.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions cross-linking/alkylation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sharma S, Gong P, Temple B, Bhattacharyya D, Dokholyan NV, Chaney SG: Molecular Dynamic Simulations of Cisplatin- and Oxaliplatin-d(GG) Intrastand Cross-links Reveal Differences in their Conformational Dynamics. J Mol Biol. 2007 Aug 23;. - Pubmed
  • Zhu G, Chang P, Lippard SJ: Recognition of platinum-DNA damage by poly(ADP-ribose) polymerase-1. Biochemistry. 2010 Jul 27;49(29):6177-83. - Pubmed
  • Ramachandran S, Temple BR, Chaney SG, Dokholyan NV: Structural basis for the sequence-dependent effects of platinum-DNA adducts. Nucleic Acids Res. 2009 May;37(8):2434-48. Epub 2009 Mar 2. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3788
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5109
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Song IS, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, Kuo MT: Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther. 2004 Dec;3(12):1543-9. - Pubmed
  • Song IS, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, Kuo MT: Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther. 2004 Dec;3(12):1543-9. - Pubmed
DTHybrid score 0.2598
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3385
Glutathione S-transferase theta-1
Name Glutathione S-transferase theta-1
Gene Name GSTT1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.3776
Metallothionein-1A
Name Metallothionein-1A
Gene Name Not Available
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score Not Available
Metallothionein-2
Name Metallothionein-2
Gene Name Not Available
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score Not Available
Myeloperoxidase
Name Myeloperoxidase
Gene Name MPO
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.5473
Superoxide dismutase [Cu-Zn]
Name Superoxide dismutase [Cu-Zn]
Gene Name SOD1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.412
Glutathione S-transferase P
Name Glutathione S-transferase P
Gene Name GSTP1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.8902
Glutathione S-transferase Mu 1
Name Glutathione S-transferase Mu 1
Gene Name GSTM1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.8634
NAD(P)H dehydrogenase [quinone] 1
Name NAD(P)H dehydrogenase [quinone] 1
Gene Name NQO1
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 1.0237

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate
References
  • Burger H, Zoumaro-Djayoon A, Boersma AW, Helleman J, Berns EM, Mathijssen RH, Loos WJ, Wiemer EA: Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2). Br J Pharmacol. 2010 Feb;159(4):898-908. Epub 2010 Jan 8. - Pubmed
DTHybrid score 0.3857
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate
References
  • Ahlin G, Karlsson J, Pedersen JM, Gustavsson L, Larsson R, Matsson P, Norinder U, Bergstrom CA, Artursson P: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. J Med Chem. 2008 Oct 9;51(19):5932-42. Epub 2008 Sep 13. - Pubmed
DTHybrid score 0.3932
High affinity copper uptake protein 1
Name High affinity copper uptake protein 1
Gene Name SLC31A1
Actions substrate
References
  • Howell SB, Safaei R, Larson CA, Sailor MJ: Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs. Mol Pharmacol. 2010 Jun;77(6):887-94. Epub 2010 Feb 16. - Pubmed
  • Song, I.S. et al. Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther 3, 1543-1549 (2004). - Pubmed
DTHybrid score 0.3961
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions substrate
References
  • Yokoo S, Masuda S, Yonezawa A, Terada T, Katsura T, Inui K: Significance of organic cation transporter 3 (SLC22A3) expression for the cytotoxic effect of oxaliplatin in colorectal cancer. Drug Metab Dispos. 2008 Nov;36(11):2299-306. Epub 2008 Aug 18. - Pubmed
DTHybrid score 0.2816
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Ceckova M, Vackova Z, Radilova H, Libra A, Buncek M, Staud F: Effect of ABCG2 on cytotoxicity of platinum drugs: interference of EGFP. Toxicol In Vitro. 2008 Dec;22(8):1846-52. Epub 2008 Sep 9. - Pubmed
DTHybrid score 0.4474
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.4145
Copper-transporting ATPase 2
Name Copper-transporting ATPase 2
Gene Name ATP7B
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.4054
Copper-transporting ATPase 1
Name Copper-transporting ATPase 1
Gene Name ATP7A
Actions substrate
References
  • https://www.pharmgkb.org/pathway/PA150642262 -
DTHybrid score 0.4054

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3597
1588 Multidrug resistance protein 1 ABCB1 0.3186
4757 Cytochrome P450 2C9 CYP2C9 0.2824
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.2762
4119 Cytochrome P450 2D6 CYP2D6 0.2538
6016 Cytochrome P450 2C19 CYP2C19 0.2203
3947 Xanthine dehydrogenase/oxidase XDH 0.2182
4924 Cytochrome P450 2C8 CYP2C8 0.1859
4118 Cytochrome P450 3A5 CYP3A5 0.1774
6030 Cytochrome P450 2B6 CYP2B6 0.1704
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1345
862 Multidrug resistance-associated protein 1 ABCC1 0.1264
118 Organic cation/carnitine transporter 2 SLC22A5 0.124
290 Prostaglandin G/H synthase 2 PTGS2 0.1199
6107 Cytochrome P450 3A7 CYP3A7 0.1183
6137 Multidrug resistance-associated protein 6 ABCC6 0.1103
4031 Glutathione S-transferase A1 GSTA1 0.1065
5718 Cytochrome P450 2A6 CYP2A6 0.1032
468 Cytochrome P450 4A11 CYP4A11 0.0995
2165 Glutathione S-transferase Mu 2 GSTM2 0.0952
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0943
20 Prostaglandin G/H synthase 1 PTGS1 0.0941
833 Organic cation/carnitine transporter 1 SLC22A4 0.088
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0877
6136 Multidrug resistance-associated protein 5 ABCC5 0.0864
776 Bile salt export pump ABCB11 0.0861
3932 Glutathione S-transferase A2 GSTA2 0.0801
587 Serum albumin ALB 0.079
6142 Solute carrier family 22 member 8 SLC22A8 0.0784
1729 Solute carrier family 22 member 6 SLC22A6 0.0756
3923 Cholinesterase BCHE 0.0743
6148 Multidrug resistance-associated protein 7 ABCC10 0.0665
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0633
817 DNA topoisomerase 2-alpha TOP2A 0.0608
2314 Triosephosphate isomerase TPI 0.0595
3417 Triosephosphate isomerase tpiA 0.0595
3443 Triosephosphate isomerase tpiA 0.0595
6346 Triosephosphate isomerase TPI1 0.0595
2164 Multidrug resistance-associated protein 4 ABCC4 0.0573
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0536
4041 Microsomal glutathione S-transferase 2 MGST2 0.0505
901 Glutathione S-transferase Mu 4 GSTM4 0.0505
275 Arachidonate 5-lipoxygenase ALOX5 0.0486
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0477
6106 Cytochrome P450 2C18 CYP2C18 0.0464
136 Estrogen receptor ESR1 0.0464
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0464
556 Alpha-1A adrenergic receptor ADRA1A 0.0461
5241 Probable thiol peroxidase tpx 0.0454
5239 Exopolyphosphatase ppx 0.0453
4407 FMN-dependent NADH-azoreductase azoR 0.045
5169 FMN-dependent NADH-azoreductase azoR 0.045
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0448
3811 Cytochrome P450 19A1 CYP19A1 0.044
4440 NADH peroxidase npr 0.044
318 Alpha-2A adrenergic receptor ADRA2A 0.0422
766 Beta-2 adrenergic receptor ADRB2 0.0418
378 Alpha-2C adrenergic receptor ADRA2C 0.0417
6143 Solute carrier family 22 member 7 SLC22A7 0.041
3941 Amine oxidase [flavin-containing] A MAOA 0.0405
492 Histamine H1 receptor HRH1 0.0403
2750 Aspartate 1-decarboxylase panD 0.0394
220 Sodium channel protein type 5 subunit alpha SCN5A 0.038
193 Beta-1 adrenergic receptor ADRB1 0.0377
502 5-hydroxytryptamine 2A receptor HTR2A 0.0372
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.037
831 D(2) dopamine receptor DRD2 0.0369
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.036
899 Glutathione S-transferase Mu 3 GSTM3 0.0359
824 Sodium-dependent serotonin transporter SLC6A4 0.0357
905 Glutathione transferase omega-1 GSTO1 0.0356
629 Alpha-2B adrenergic receptor ADRA2B 0.0348
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0346
3939 Amine oxidase [flavin-containing] B MAOB 0.0343
713 Sodium-dependent dopamine transporter SLC6A3 0.0341
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0334
153 Dopamine beta-hydroxylase DBH 0.0333
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0325
3759 Glutathione S-transferase gst 0.0325
4541 Glutathione S-transferase GST 0.0325
1024 Solute carrier family 22 member 11 SLC22A11 0.0321
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.032
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0316
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0315
6141 Sodium/bile acid cotransporter SLC10A1 0.0315
477 DNA topoisomerase 4 subunit A parC 0.0313
886 DNA topoisomerase 4 subunit A parC 0.0313
6226 DNA topoisomerase 4 subunit A parC 0.0313
23 D(1A) dopamine receptor DRD1 0.0313
1736 Somatostatin SST 0.0311
4186 Neuropeptide Y receptor type 2 NPY2R 0.0311
3873 Prolyl endopeptidase PREP 0.031
6928 Prolyl endopeptidase Not Available 0.031
632 Alpha-1B adrenergic receptor ADRA1B 0.0309
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0309
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0308
404 DNA gyrase subunit A gyrA 0.0308
6224 DNA gyrase subunit A gyrA 0.0308
341 5-hydroxytryptamine 3 receptor HTR3A 0.0307
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0298
2159 Quinone oxidoreductase CRYZ 0.0297
4192 DNA topoisomerase 2-beta TOP2B 0.0287
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0285
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0285
86 SEC14-like protein 4 SEC14L4 0.0284
375 SEC14-like protein 3 SEC14L3 0.0284
4076 Diacylglycerol kinase alpha DGKA 0.0284
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0275
789 Alpha-1D adrenergic receptor ADRA1D 0.0272
6020 Aldehyde oxidase AOX1 0.0272
465 Calmodulin CALM1 0.0272
563 Thyroid peroxidase TPO 0.0269
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0268
997 Protein kinase C beta type PRKCB 0.0267
1313 Lactoylglutathione lyase GLO1 0.0265
723 Cytosolic phospholipase A2 PLA2G4A 0.0265
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0264
283 SEC14-like protein 2 SEC14L2 0.0261
708 Alpha-tocopherol transfer protein TTPA 0.0261
36 Insulin receptor INSR 0.0258
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0254
54 Prothrombin F2 0.0252
309 Antithrombin-III SERPINC1 0.0251
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0249
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0246
6014 Cytochrome P450 2A13 CYP2A13 0.0246
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0246
239 Coagulation factor X F10 0.0244
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0244
1970 Protein kinase C alpha type PRKCA 0.0243
320 5-hydroxytryptamine 1A receptor HTR1A 0.0243
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0241
4773 Deoxycytidine kinase DCK 0.0241
4203 Histamine N-methyltransferase HNMT 0.024
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0239
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0237
124 Histamine H2 receptor HRH2 0.0233
4103 Proteasome subunit beta type 2 PSMB2 0.0223
4101 Proteasome subunit beta type 1 PSMB1 0.0223
4102 Proteasome subunit beta type 5 PSMB5 0.0223
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0222
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0221
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0221
5626 Nucleoside diphosphate kinase B NME2 0.0219
6220 Aryl hydrocarbon receptor AHR 0.0218
16 Adenosine A1 receptor ADORA1 0.0217
844 Epidermal growth factor receptor EGFR 0.0217
503 Somatostatin receptor type 1 SSTR1 0.0214
3866 Serum amyloid A protein SAA1 0.0209
1932 Apolipoprotein E APOE 0.0208
1200 AMBP protein AMBP 0.0208
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0207
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0207
7 Nitric oxide synthase, inducible NOS2 0.0205
590 5-hydroxytryptamine 2C receptor HTR2C 0.0205
2443 Azurin azu 0.0205
70 Type-1 angiotensin II receptor AGTR1 0.0205
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0204
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0203
131 Synaptic vesicular amine transporter SLC18A2 0.0203
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0203
856 Vitamin D3 receptor VDR 0.0202
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0201
810 Heme oxygenase 1 HMOX1 0.0201
3391 Heme oxygenase 1 pbsA1 0.0201
504 Mast/stem cell growth factor receptor KIT 0.0201
3872 Somatostatin receptor type 5 SSTR5 0.02
6008 Somatostatin receptor type 2 SSTR2 0.02
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.02
885 5-hydroxytryptamine 1B receptor HTR1B 0.0198
6070 Nischarin NISCH 0.0196
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0193
4120 NADPH--cytochrome P450 reductase POR 0.0191
777 Tumor necrosis factor TNF 0.019
29 Tubulin beta-1 chain TUBB1 0.0189
4604 Liver carboxylesterase 1 CES1 0.0188
228 Beta platelet-derived growth factor receptor PDGFRB 0.0182
474 Acetylcholinesterase ACHE 0.0182
33 Cystine/glutamate transporter SLC7A11 0.0182
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0181
1178 Adenosine A2a receptor ADORA2A 0.0181
1405 Thiopurine S-methyltransferase TPMT 0.0181
1353 DNA topoisomerase 1 TOP1 0.0179
3552 DNA topoisomerase 1 topA 0.0179
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0179
5294 Nucleoside diphosphate kinase A NME1 0.0176
869 Estrogen receptor beta ESR2 0.0175
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0173
1517 Beta-3 adrenergic receptor ADRB3 0.0173
756 Sex hormone-binding globulin SHBG 0.0172
161 Tubulin beta chain TUBB 0.0171
312 Tubulin beta chain TUB2 0.0171
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.017
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.017
638 D(3) dopamine receptor DRD3 0.017
6432 Transporter snf 0.0167
4228 Keratin, type II cytoskeletal 7 KRT7 0.0167
6031 Cytochrome P450 3A43 CYP3A43 0.0166
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0164
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0162
613 Atrial natriuretic peptide receptor A NPR1 0.0161
115 Penicillin-binding protein 2 mrdA 0.016
6069 Penicillin-binding protein 2 mrdA 0.016
6118 Penicillin-binding protein 2 penA 0.016
6187 Penicillin-binding protein 2 pbpA 0.016
6686 Penicillin-binding protein 2 pbp2 0.016
6939 Penicillin-binding protein 2 mrdA 0.016
7163 Penicillin-binding protein 2 pbpA 0.016
867 Penicillin-binding protein 3 pbpC 0.016
6119 Penicillin-binding protein 3 pbp3 0.016
7154 Penicillin-binding protein 3 pbp3 0.016
7157 Penicillin-binding protein 3 LMHCC_2184 0.016
7162 Penicillin-binding protein 3 pbpB 0.016
7172 Penicillin-binding protein 3 pbp3 0.016
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.016
6010 Thiamine transporter 1 SLC19A2 0.0159
2472 Voltage-gated potassium channel kcsA 0.0157
6366 Voltage-gated potassium channel kcsA 0.0157
6012 Tryptophan 2,3-dioxygenase TDO2 0.0155
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
5898 Complement C3 C3 0.0154
731 HIV-1 protease HIV-1 protease 0.0153
260 Cytochrome P450 51 ERG11 0.0152
761 Cytochrome P450 51 ERG11 0.0152
3163 Cytochrome P450 51 cyp51 0.0152
273 Apoptosis regulator Bcl-2 BCL2 0.0151
725 5-hydroxytryptamine 1D receptor HTR1D 0.0151
450 Muscarinic acetylcholine receptor M4 CHRM4 0.015
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0148
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0147
4035 Glutathione S-transferase Mu 5 GSTM5 0.0147
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0146
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0146
117 Sterol O-acyltransferase 1 SOAT1 0.0145
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0144
571 Melatonin receptor type 1A MTNR1A 0.0143
362 Melatonin receptor type 1B MTNR1B 0.0143
1629 Transcription factor AP-1 JUN 0.0143
164 Histamine H4 receptor HRH4 0.0142
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0142
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0142
432 D(4) dopamine receptor DRD4 0.0141
1928 Leukotriene C4 synthase LTC4S 0.014
900 Glutathione S-transferase A4 GSTA4 0.014
4043 Glutaredoxin-2, mitochondrial GLRX2 0.014
4037 Hypothetical protein GPX1 0.014
4297 Hypothetical protein SP_1951 0.014
4521 Hypothetical protein BC_2969 0.014
4540 Hypothetical protein TM_1070 0.014
4555 Hypothetical protein MT1739 0.014
4569 Hypothetical protein mshD 0.014
4578 Hypothetical protein PA3270 0.014
4747 Hypothetical protein PA3967 0.014
5177 Hypothetical protein TM_0096 0.014
5194 Hypothetical protein PA1204 0.014
5240 Hypothetical protein Rv2991 0.014
5370 Hypothetical protein TM_1158 0.014
5710 Hypothetical protein Tb927.5.1360 0.014
906 Glutathione peroxidase 1 GPX1 0.014
903 Glutathione S-transferase A5 GSTA5 0.014
4034 Glutaredoxin-1 GLRX 0.014
4029 Microsomal glutathione S-transferase 3 MGST3 0.014
4032 Microsomal glutathione S-transferase 1 MGST1 0.014
4042 Glutathione transferase omega-2 GSTO2 0.014
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.014
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.014
4036 Glutathione peroxidase 6 GPX6 0.014
4040 Glutathione peroxidase 7 GPX7 0.014
907 Glutathione peroxidase 2 GPX2 0.014
4038 Glutathione peroxidase 4 GPX4 0.014
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.014
911 Glutathione peroxidase 3 GPX3 0.014
910 Epididymal secretory glutathione peroxidase GPX5 0.014
4033 S-formylglutathione hydrolase ESD 0.014
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.014
714 Glutathione reductase, mitochondrial GSR 0.0139
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0139
380 Cytochrome P450 17A1 CYP17A1 0.0139
6168 Solute carrier family 22 member 16 SLC22A16 0.0139
146 Androgen receptor AR 0.0139
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0138
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0138
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0138
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0138
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0138
738 Monocarboxylate transporter 1 SLC16A1 0.0137
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0135
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0135
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0133
5923 Microtubule-associated protein tau MAPT 0.0133
5924 Microtubule-associated protein 4 MAP4 0.0133
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0133
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0133
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0132
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0132
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0132
633 Penicillin-binding proteins 1A/1B pbpA 0.0132
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0132
614 Progesterone receptor PGR 0.0132
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0131
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0131
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.013
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.013
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0129
790 DNA polymerase subunit alpha B POLA2 0.0129
3830 Calreticulin CALR 0.0128
3917 Methylenetetrahydrofolate reductase MTHFR 0.0128
897 Glutathione S-transferase kappa 1 GSTK1 0.0127
898 Glutathione S-transferase A3 GSTA3 0.0126
3319 Hydroxyacylglutathione hydrolase HAGH 0.0126
2449 Tubulin alpha-3 chain TUBA1A 0.0125
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
5126 Arginase rocF 0.0125
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0125
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0124
6036 Eosinophil peroxidase EPX 0.0124
1852 Microtubule-associated protein 2 MAP2 0.0124
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0123
909 Maleylacetoacetate isomerase GSTZ1 0.0123
1636 Trace amine-associated receptor 1 TAAR1 0.0122
6677 Myelin P2 protein PMP2 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
6034 Hydroxyindole O-methyltransferase ASMT 0.0121
6035 Nuclear receptor ROR-beta RORB 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
4122 Histone deacetylase 2 HDAC2 0.012
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0119
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0118
1714 Mitogen-activated protein kinase 3 MAPK3 0.0118
603 DNA polymerase alpha catalytic subunit POLA1 0.0118
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0118
1341 Histamine H3 receptor HRH3 0.0117
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0116
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
48 Pyridoxal kinase PDXK 0.0116
2517 Subtilisin BPN' apr 0.0116
373 Transthyretin TTR 0.0115
122 P2Y purinoceptor 12 P2RY12 0.0114
871 Glucocorticoid receptor NR3C1 0.0113
3810 Catechol O-methyltransferase COMT 0.0113
6102 Arylamine N-acetyltransferase 2 NAT2 0.0113
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0112
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0111
1010 Cytochrome P450 51A1 CYP51A1 0.0111
436 5-hydroxytryptamine 2B receptor HTR2B 0.0111
163 D(1B) dopamine receptor DRD5 0.0109
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0109
828 Phenylalanine-4-hydroxylase PAH 0.0108
3109 Phenylalanine-4-hydroxylase phhA 0.0108
2539 Tubulin alpha-1 chain TUBA4A 0.0106
1569 G1/S-specific cyclin-D1 CCND1 0.0106
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0106
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0106
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0106
400 Coagulation factor IX F9 0.0105
5461 Coagulation factor IX F9 0.0105
2596 Acetyl-CoA acetyltransferase phbA 0.0105
737 Mineralocorticoid receptor NR3C2 0.0105
26 Vascular endothelial growth factor receptor 3 FLT4 0.0105
765 Indoleamine 2,3-dioxygenase IDO1 0.0105
207 Glutathione synthetase GSS 0.0104
5269 Glutathione synthetase gshB 0.0104
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0104
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0104
702 UMP-CMP kinase CMPK1 0.0103
461 Glycine receptor subunit alpha-3 GLRA3 0.0102
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0102
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0102
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0101
32 Vascular endothelial growth factor receptor 1 FLT1 0.0101
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0098
604 Vitamin K-dependent protein Z PROZ 0.0098
1650 Heme carrier protein 1 SLC46A1 0.0097
624 Guanidinoacetate N-methyltransferase GAMT 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0096
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0096
992 Protein tyrosine kinase 2 beta PTK2B 0.0095
444 Alcohol dehydrogenase 1B ADH1B 0.0095
1830 5'-nucleotidase NT5E 0.0094
2499 Tubulin beta-2C chain TUBB2C 0.0094
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0093
342 P protein [Includes: DNA-directed DNA polymerase P 0.0091
612 P protein [Includes: DNA-directed DNA polymerase P 0.0091
1192 Sulfotransferase 1A1 SULT1A1 0.0091
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0091
6085 Fatty acid-binding protein, intestinal FABP2 0.0091
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0091
407 Vascular endothelial growth factor receptor 2 KDR 0.0091
1176 Mitogen-activated protein kinase 1 MAPK1 0.009
6766 O-GlcNAcase BT_4395 BT_4395 0.0089
482 Glycine receptor subunit alpha-1 GLRA1 0.0089
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0089
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0088
1245 Vitamin K-dependent protein S PROS1 0.0088
422 Vitamin K-dependent protein C PROC 0.0088
4311 tRNA TRDMT1 0.0088
4325 tRNA trmD 0.0088
4328 tRNA trmD 0.0088
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0087
6599 HTH-type transcriptional regulator ttgR ttgR 0.0087
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0087
694 Matrix protein 2 M 0.0086
6171 Solute carrier family 28 member 3 SLC28A3 0.0085
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0085
2236 Casein kinase II subunit alpha CSNK2A1 0.0084
976 Platelet glycoprotein IX GP9 0.0084
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0084
6167 Organic solute transporter subunit beta OSTB 0.0083
6166 Organic solute transporter subunit alpha OSTA 0.0083
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0082
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0082
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0081
850 Vasopressin V1b receptor AVPR1B 0.0081
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0081
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0081
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0081
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0081
3601 Dihydropteroate synthase 1 folP1 0.0081
3807 Dihydropteroate synthase 1 folP1 0.0081
3808 Dihydropteroate synthase 2 folP2 0.0081
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.008
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.008
1063 Signal transducer and activator of transcription 5B STAT5B 0.008
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.008
6138 Multidrug resistance protein 3 ABCB4 0.008
6111 DNA polymerase epsilon subunit 4 POLE4 0.008
6112 DNA polymerase epsilon subunit 3 POLE3 0.008
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.008
6110 DNA polymerase epsilon subunit 2 POLE2 0.008
6109 DNA polymerase epsilon catalytic subunit A POLE 0.008
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0079
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0079
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0078
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0078
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0078
469 Annexin A1 ANXA1 0.0078
798 Osteocalcin BGLAP 0.0078
936 Ephrin type-A receptor 2 EPHA2 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0076
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0075
24 Thymidylate synthase TMP1 0.0075
359 Thymidylate synthase TYMS 0.0075
2626 Thymidylate synthase thyA 0.0075
2729 Thymidylate synthase thyA 0.0075
5352 Thymidylate synthase THYA 0.0075
125 DNA polymerase beta POLB 0.0074
84 Nuclear receptor 0B1 NR0B1 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
165 FL cytokine receptor FLT3 0.0073
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0073
814 Ryanodine receptor 1 RYR1 0.0073
484 Tyrosine-protein kinase ABL2 ABL2 0.0073
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0072
185 Vasopressin V1a receptor AVPR1A 0.0071
2417 Chloramphenicol acetyltransferase cat 0.0071
3278 Chloramphenicol acetyltransferase cat 0.0071
369 Coagulation factor VII F7 0.0071
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
2300 Lysozyme E 0.007
3633 Lysozyme R 0.007
5597 Lysozyme 17 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.007
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.007
3927 Choline transporter-like protein 3 SLC44A3 0.007
823 Fibroblast growth factor receptor 2 FGFR2 0.007
3926 Choline transporter-like protein 2 SLC44A2 0.007
3933 Choline/ethanolaminephosphotransferase CEPT1 0.007
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.007
1686 Choline transporter-like protein 1 SLC44A1 0.007
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.007
861 Choline kinase alpha CHKA 0.007
769 High-affinity choline transporter 1 SLC5A7 0.007
3925 Choline transporter-like protein 4 SLC44A4 0.007
700 Choline dehydrogenase, mitochondrial CHDH 0.007
576 Choline O-acetyltransferase CHAT 0.007
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.007
3922 Phospholipase D2 PLD2 0.007
3924 Phospholipase D1 PLD1 0.007
322 Vasopressin V2 receptor AVPR2 0.007
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0069
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0069
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0069
5682 Ribonuclease pancreatic RNASE1 0.0069
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0068
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0068
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0068
1360 Sphingomyelin phosphodiesterase SMPD1 0.0068
76 Nitric-oxide synthase, brain NOS1 0.0067
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0067
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0067
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
820 Glycine receptor subunit alpha-2 GLRA2 0.0067
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0067
751 Potassium channel subfamily K member 6 KCNK6 0.0066
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
537 ATP synthase delta chain, mitochondrial ATP5D 0.0066
268 Adenosine A2b receptor ADORA2B 0.0065
3709 Glycerol uptake facilitator protein glpF 0.0065
3116 Bacterioferritin bfr 0.0065
4906 Bacterioferritin bfr 0.0065
4965 Bacterioferritin bfr 0.0065
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0065
3173 Enolase eno 0.0065
3393 TGF-beta receptor type-2 TGFBR2 0.0065
3238 Multidrug resistance protein mexA mexA 0.0065
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0065
3611 Cytidine deaminase cdd 0.0065
3707 Cytidine deaminase cdd 0.0065
4211 Cytidine deaminase CDA 0.0065
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0064
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0064
1820 Beta-nerve growth factor NGF 0.0064
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0063
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0063
705 Glutamate receptor 1 GRIA1 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
251 Alcohol dehydrogenase 1A ADH1A 0.0063
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0062
3270 Elongation factor G fusA 0.0062
1618 High affinity nerve growth factor receptor NTRK1 0.0062
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0062
511 5-hydroxytryptamine 1F receptor HTR1F 0.0062
172 Potassium channel subfamily K member 1 KCNK1 0.0061
3957 Adenosine deaminase ADA 0.0061
2808 Chloramphenicol acetyltransferase 3 cat3 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
6149 Solute carrier family 22 member 10 SLC22A10 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
3937 Fatty-acid amide hydrolase FAAH 0.0059
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0059
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0058
291 Nitric-oxide synthase, endothelial NOS3 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
293 Gamma-glutamyl hydrolase GGH 0.0058
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0058
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0058
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0057
2852 DNA mismatch repair protein mutL mutL 0.0057
94 5-hydroxytryptamine 4 receptor HTR4 0.0057
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0057
551 Carnitine O-acetyltransferase CRAT 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
921 Glutamate receptor 2 GRIA2 0.0056
771 Pyruvate carboxylase, mitochondrial PC 0.0056
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0055
6211 Tubulin epsilon chain TUBE1 0.0055
6210 Tubulin delta chain TUBD1 0.0055
6212 Tubulin gamma-1 chain TUBG1 0.0055
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0055
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0055
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0054
517 Alcohol dehydrogenase 1C ADH1C 0.0054
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0054
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0054
106 Cannabinoid receptor 2 CNR2 0.0054
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0054
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0054
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0053
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0053
5934 Cytochrome P450 26A1 CYP26A1 0.0053
183 Vascular endothelial growth factor A VEGFA 0.0053
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0053
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0053
3191 Histidinol dehydrogenase hisD 0.0053
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0053
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0053
3221 Cytochrome c4 cc4 0.0053
6459 Glycodelin PAEP 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
1864 RET proto-oncogene RET 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0052
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0052
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0052
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
68 Cannabinoid receptor 1 CNR1 0.0051
847 Mu-type opioid receptor OPRM1 0.005
5787 Angiopoietin-1 receptor TEK 0.0049
489 Monocarboxylate transporter 2 SLC16A7 0.0049
1760 Aminopeptidase N ANPEP 0.0049
6843 Aminopeptidase N pepN 0.0049
4692 A/G-specific adenine glycosylase mutY 0.0048
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0047
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0047
6182 Cytochrome P450 2J2 CYP2J2 0.0047
1256 5-hydroxytryptamine 6 receptor HTR6 0.0047
716 5-hydroxytryptamine 7 receptor HTR7 0.0046
277 Purine nucleoside phosphorylase PNP 0.0046
2870 Purine nucleoside phosphorylase punA 0.0046
2945 Purine nucleoside phosphorylase punA 0.0046
4659 Purine nucleoside phosphorylase TM_1596 0.0046
4825 Purine nucleoside phosphorylase TTHA1435 0.0046
3809 Estrogen-related receptor gamma ESRRG 0.0046
2802 Endoglucanase G celCCG 0.0046
6043 Putative G-protein coupled receptor 44 GPR44 0.0046
303 Diamine acetyltransferase 2 SAT2 0.0045
718 Folate receptor gamma FOLR3 0.0045
804 Mitochondrial folate transporter/carrier SLC25A32 0.0045
299 Folate receptor beta FOLR2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
696 Kappa-type opioid receptor OPRK1 0.0045
6316 ADP-ribosylation factor 1 ARF1 0.0045
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0045
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0044
390 Adenosine A3 receptor ADORA3 0.0044
6044 Serum paraoxonase/lactonase 3 PON3 0.0044
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
467 Delta-type opioid receptor OPRD1 0.0043
6218 Pannexin-1 PANX1 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0042
3587 Gastrotropin FABP6 0.0042
811 Translocator protein TSPO 0.0041
4217 Telomerase reverse transcriptase TERT 0.0041
3856 Fibroblast growth factor receptor 3 FGFR3 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
734 D1 dopamine receptor-interacting protein calcyon CALY 0.004
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0039
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0038
295 Carbonic anhydrase 1 CA1 0.0038
6837 Serine/threonine-protein kinase 17B STK17B 0.0038
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
1374 Natriuretic peptides B NPPB 0.0037
1827 Gap junction alpha-1 protein GJA1 0.0037
1908 Vascular cell adhesion protein 1 VCAM1 0.0037
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0037
527 Prostacyclin receptor PTGIR 0.0036
365 Dihydrofolate reductase DHFR 0.0036
2381 Dihydrofolate reductase DFR1 0.0036
2833 Dihydrofolate reductase Not Available 0.0036
2931 Dihydrofolate reductase folA 0.0036
3544 Dihydrofolate reductase folA 0.0036
3682 Dihydrofolate reductase folA 0.0036
6642 Dihydrofolate reductase folA 0.0036
6756 Dihydrofolate reductase dfrA 0.0036
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
5448 Ribonuclease Z rnz 0.0035
5449 Hypothetical gliding protein mglB 0.0035
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0035
4705 Manganese catalase Not Available 0.0035
5439 33 kDa chaperonin hslO 0.0035
332 Beta-lactamase blaZ 0.0035
2478 Beta-lactamase ampC 0.0035
2613 Beta-lactamase ampC 0.0035
2635 Beta-lactamase ampC 0.0035
2700 Beta-lactamase penP 0.0035
5445 Beta-lactamase blaB 0.0035
6019 Beta-lactamase SHV-7 0.0035
6701 Beta-lactamase cphA 0.0035
5443 UPF0189 protein ymdB ymdB 0.0035
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0035
5440 UPF0067 protein yebR yebR 0.0035
284 DNA-directed RNA polymerase beta chain rpoB 0.0035
5773 DNA-directed RNA polymerase beta chain rpoB 0.0035
2720 Copper-containing nitrite reductase nirK 0.0035
5454 Internalin-A inlA 0.0035
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0035
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0035
357 Carbonic anhydrase 2 CA2 0.0035
6126 Carbonic anhydrase 7 CA7 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
4498 Ornithine cyclodeaminase PP3533 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
4116 Dihydropteroate synthetase Not Available 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0033
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0033
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0033
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
2320 Thymidine kinase, cytosolic TK1 0.0032
518 Peroxidase/catalase T katG 0.0032
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
5450 Prolyl endopeptidase Pep pep 0.0031
4771 Dissimilatory copper-containing nitrite reductase nir 0.0031
3356 Diaminopimelate decarboxylase lysA 0.0031
2714 Chorismate mutase aroH 0.0031
4611 Chorismate mutase aroG 0.0031
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0031
3274 Hydroxylamine reductase hcp 0.0031
4804 Hydroxylamine reductase hcp 0.0031
634 Squalene monooxygenase SQLE 0.0031
7196 Squalene monooxygenase ERG1 0.0031
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0031
528 5-hydroxytryptamine 1E receptor HTR1E 0.0031
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0031
818 50S ribosomal protein L10 rplJ 0.003
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.003
173 Toll-like receptor 7 TLR7 0.003
2112 Toll-like receptor 9 TLR9 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
3399 Limonene-1,2-epoxide hydrolase limA 0.0029
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0028
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0028
2599 Tyrosine-protein kinase HCK HCK 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0028
592 Carbonic anhydrase 4 CA4 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0028
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0028
597 Dihydropteridine reductase QDPR 0.0028
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0028
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0028
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0027
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0027
3404 Exotoxin A eta 0.0027
5180 L(+)-mandelate dehydrogenase mdlB 0.0027
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0027
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0027
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0027
3500 Putative family 31 glucosidase yicI yicI 0.0027
4608 Putative cytochrome P450 SCO1207 0.0027
4963 Putative cytochrome P450 SCO2884 0.0027
6254 Putative cytochrome P450 SCO6998 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
3480 Mannan endo-1,4-beta-mannosidase manA 0.0027
577 Argininosuccinate lyase ASL 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
1275 Estrogen sulfotransferase SULT1E1 0.0026
1615 Chymase CMA1 0.0026
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0026
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0025
1050 Bile salt sulfotransferase SULT2A1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0025
4226 Uridine phosphorylase 2 UPP2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
6228 Nuclear receptor coactivator 1 NCOA1 0.0024
569 Retinal dehydrogenase 2 ALDH1A2 0.0024
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0024
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0024
6241 Nuclear receptor coactivator 2 NCOA2 0.0024
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2981 Phospholipase A2, membrane associated PLA2G2A 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
822 Aldose reductase AKR1B1 0.0023
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0023
358 Cystathionine beta-synthase CBS 0.0023
4225 Uridine phosphorylase 1 UPP1 0.0022
611 Retinal dehydrogenase 1 ALDH1A1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0022
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0022
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0022
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0022
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0022
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
5818 Folate receptor alpha FOLR1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
413 Amidophosphoribosyltransferase PPAT 0.0021
2515 Amidophosphoribosyltransferase purF 0.0021
3714 Amidophosphoribosyltransferase purF 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.002
859 Cellular retinoic acid-binding protein 2 CRABP2 0.002
2298 Cytochrome P450-cam camC 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.002
1630 Integrin beta-2 ITGB2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.002
780 Retinoic acid receptor RXR-gamma RXRG 0.002
3007 Carbonic anhydrase 12 CA12 0.002
4205 Carbonic anhydrase 9 CA9 0.002
606 Cytochrome P450 27, mitochondrial CYP27A1 0.002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
2408 Tyrosine-protein kinase SYK SYK 0.0019
5122 Mersacidin decarboxylase mrsD 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0019
5095 Putidaredoxin reductase camA 0.0019
3763 5,10-methylenetetrahydrofolate reductase metF 0.0019
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0019
5094 5,10-methylenetetrahydrofolate reductase metF 0.0019
526 Thioredoxin reductase trxB 0.0019
3767 Thioredoxin reductase trxB 0.0019
5078 Amine oxidase, flavin-containing PSPTO1126 0.0019
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0019
5109 Outer membrane protein p64k or PM-6 m-6 0.0019
5115 FkbI fkbI 0.0019
5083 Cryptochrome DASH cry 0.0019
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0019
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0019
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0019
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0019
5081 L-aspartate oxidase nadB 0.0019
1410 Oxidoreductase HSD17B6 0.0019
4725 Oxidoreductase Not Available 0.0019
5124 Oxidoreductase Not Available 0.0019
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0019
3133 UDP-galactopyranose mutase glf 0.0019
5099 UDP-galactopyranose mutase glf 0.0019
5111 Phenylacetone monooxygenase pamO 0.0019
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
4486 Phenol 2-hydroxylase component B pheA2 0.0018
4477 Dihydrolipoyl dehydrogenase lpdV 0.0018
5077 Dihydrolipoyl dehydrogenase Not Available 0.0018
5117 Dihydrolipoyl dehydrogenase lpd 0.0018
4439 Ferredoxin reductase bphA4 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
1992 Vitamin D-binding protein GC 0.0018
760 Fibroblast growth factor 1 FGF1 0.0018
88 Retinoic acid receptor RXR-beta RXRB 0.0018
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
162 Retinoic acid receptor gamma-1 RARG 0.0017
3639 Thymidine phosphorylase deoA 0.0017
3936 Thymidine phosphorylase TYMP 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
1648 Elastin ELN 0.0017
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0017
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0017
2268 Cholesterol oxidase choB 0.0017
2822 Cholesterol oxidase choA 0.0017
5072 N,N-dimethylglycine oxidase dmg 0.0017
5073 Ferredoxin--NADP reductase petH 0.0017
5076 Ferredoxin--NADP reductase fpr 0.0017
5119 Ferredoxin--NADP reductase petH 0.0017
5121 Ferredoxin--NADP reductase fpr 0.0017
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0017
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0017
3594 Deoxyribodipyrimidine photo-lyase phr 0.0017
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0017
5080 Deoxyribodipyrimidine photo-lyase phr 0.0017
2526 NADPH-ferredoxin reductase fprA fprA 0.0017
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0017
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0017
1656 CYP2B protein CYP2B 0.0017
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0017
2470 Pyruvate oxidase pox5 0.0017
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0017
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0017
3102 Flavohemoprotein hmp 0.0016
4969 Flavohemoprotein hmp 0.0016
1243 Cathepsin D CTSD 0.0016
427 Substance-P receptor TACR1 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0015
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0015
2893 Glycine oxidase thiO 0.0015
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0015
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0015
327 Glutathione reductase gor 0.0015
5110 Glutathione reductase GR2 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
126 D-lactate dehydrogenase dld 0.0015
3545 D-lactate dehydrogenase Not Available 0.0015
4510 D-lactate dehydrogenase ldhA 0.0015
572 Integrin alpha-L ITGAL 0.0015
2567 Thymidylate synthase thyX thyX 0.0015
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0015
2823 Trypanothione reductase TPR 0.0015
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0014
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0014
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0014
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0014
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0014
2769 P-hydroxybenzoate hydroxylase pobA 0.0014
2809 P-hydroxybenzoate hydroxylase pobA 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
2380 Monomeric sarcosine oxidase soxA 0.0013
6824 Tyrosine-protein kinase Lyn LYN 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
6645 D-amino-acid oxidase DAO 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0012
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
6042 Prostaglandin reductase 2 PTGR2 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
340 Apoptotic protease-activating factor 1 APAF1 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
4237 50S ribosomal protein L22 rplV 0.001
345 Plasma retinol-binding protein RBP4 0.001
825 Arsenical pump-driving ATPase ASNA1 0.001
3435 Arsenical pump-driving ATPase arsA 0.001
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.001
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.001
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.001
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.001
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.001
733 Activin receptor type 1B ACVR1B 0.001
154 AFG3-like protein 2 AFG3L2 0.001
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.001
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.001
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.001
395 ALK tyrosine kinase receptor Not Available 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
229 Retinoic acid receptor beta RARB 0.0009
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0009
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0009
6493 Cytochrome c oxidase subunit 6C COX6C 0.0009
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0009
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0009
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0009
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0009
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0009
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0009
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0009
6559 Cytochrome c oxidase subunit 2 ctaC 0.0009
6669 Cytochrome c oxidase subunit 2 ctaC 0.0009
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0009
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0009
6558 Cytochrome c oxidase subunit 1 ctaD 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
292 Activin receptor type-1 ACVR1 0.0009
849 Activated CDC42 kinase 1 TNK2 0.0009
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0009
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0009
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0009
297 Adenylate cyclase type 1 ADCY1 0.0009
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
2540 Choloylglycine hydrolase cbh 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0007
740 Argininosuccinate synthase ASS1 0.0007
865 Argininosuccinate synthase ASS1 0.0007
2680 Argininosuccinate synthase argG 0.0007
3194 Argininosuccinate synthase argG 0.0007
952 Dipeptidyl peptidase 4 DPP4 0.0007
6021 Adenosine kinase ADK 0.0007
661 ADP/ATP translocase 1 SLC25A4 0.0007
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
2207 Rhodopsin RHO 0.0006
1039 Histone deacetylase 9 HDAC9 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
↑