DT-Web

DB01030 - Topotecan


Identification
Name Topotecan
Accession Number DB01030 (APRD00687)
Type small molecule
Description An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 421.4458
Groups approved
Monoisotopic Weight 421.163770861
Pharmacology
Indication For the treatment of advanced ovarian cancer in patients with disease that has recurred or progressed following therapy with platinum-based regimens. Also used as a second-line therapy for treatment-sensitive small cell lung cancer, as well as in combination with cisplatin for the treatment of stage IV-B, recurrent, or persistent cervical cancer not amenable to curative treatment with surgery and/or radiation therapy.
Mechanism of action Topotecan has the same mechanism of action as irinotecan and is believed to exert its cytotoxic effects during the S-phase of DNA synthesis. Topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks. Topotecan binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. This ternary complex interferes with the moving replication fork, which leads to the induction of replication arrest and lethal double-stranded breaks in DNA. As mammalian cells cannot efficiently repair these double strand breaks, the formation of this ternary complex eventually leads to apoptosis (programmed cell death). Topotecan mimics a DNA base pair and binds at the site of DNA cleavage by intercalating between the upstream (-1) and downstream (+1) base pairs. Intercalation displaces the downstream DNA, thus preventing religation of the cleaved strand. By specifically binding to the enzyme-substrate complex, Topotecan acts as an uncompetitive inhibitor.
Absorption Not Available
Protein binding 35%
Biotransformation Topotecan undergoes a reversible pH dependent hydrolysis of its lactone moiety; it is the lactone form that is pharmacologically active.
Route of elimination Renal clearance is an important determinant of topotecan elimination. In a mass balance/excretion study in 4 patients with solid tumors, the overall recovery of total topotecan and its N-desmethyl metabolite in urine and feces over 9 days averaged 73.4 ? 2.3% of the administered IV dose. Fecal elimination of total topotecan accounted for 9 ? 3.6% while fecal elimination of N-desmethyl topotecan was 1.7 ? 0.6%.
Toxicity The primary anticipated complication of overdosage would consist of bone marrow suppression.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amiodarone The p-glycoprotein inhibitor, Amiodarone, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Atorvastatin The p-glycoprotein inhibitor, Atorvastatin, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Carboplatin Administration of Topotecan after Carboplatin therapy may increase the risk of hematologic toxicity, such as neutropenia and/or thrombocytopenia. A dose adjustment may be required or the sequence of administration reversed.
Carvedilol The p-glycoprotein inhibitor, Carvedilol, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Cisplatin Administration of Topotecan after Cisplatin therapy may increase the risk of hematologic toxicity, such as neutropenia and/or thrombocytopenia. A dose adjustment may be required or the sequence of administration reversed.
Clarithromycin The p-glycoprotein inhibitor, Clarithromycin, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Cyclosporine The p-glycoprotein inhibitor, Cyclosporine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Darunavir The p-glycoprotein inhibitor, Darunavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Dipyridamole The p-glycoprotein inhibitor, Dipyridamole, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Erythromycin The p-glycoprotein inhibitor, Erythromycin, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Filgrastim Filgrastim may increase the adverse effects of Topotecan. Increased risk of prolonged neutropenia. Filgrastim should be administered at least 24 hours following Topotecan therapy. Monitor for signs and symptoms of neutropenia.
Gefitinib The BCRP/ABCG2 inhibitor, Gefitnib, may increase the bioavailability and serum concentration of oral Topotecan. Monitor for change in the therapeutic and adverse effects of Topotecan if Gefitinib is initiated, discontinued or dose changed.
Imatinib The BCRP/ABCG2 inhibitor, Imatinib, may increase the bioavailability and serum concentration of oral Topotecan. Monitor for change in the therapeutic and adverse effects of Topotecan if Imatinib is initiated, discontinued or dose changed.
Itraconazole The p-glycoprotein inhibitor, Itraconazole, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Ketoconazole The p-glycoprotein inhibitor, Ketoconazole, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Lapatinib The p-glycoprotein inhibitor, Lapatinib, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Lopinavir The p-glycoprotein inhibitor, Lopinavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Mefloquine The p-glycoprotein inhibitor, Mefloquine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Natalizumab The immunosuppressant, Topotecan, may increase the adverse effects of Natalizumab. Increased risk of Progressive Multifocal Leukoencephalopathy (PML) and other infections. Concurrent therapy should be avoided.
Nelfinavir The p-glycoprotein inhibitor, Nelfinavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Nicardipine The p-glycoprotein inhibitor, Nicardipine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Nilotinib The p-glycoprotein inhibitor, Nilotinib, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Oxaliplatin Administration of Topotecan after Oxaliplatin therapy may increase the risk of hematologic toxicity, such as neutropenia and/or thrombocytopenia. A dose adjustment may be required or the sequence of administration reversed.
Pantoprazole The BCRP/ABCG2 inhibitor, Pantaprazole, may increase the bioavailability and serum concentration of oral Topotecan. Monitor for change in the therapeutic and adverse effects of Topotecan if Pantaprazole is initiated, discontinued or dose changed.
Progesterone The p-glycoprotein inhibitor, Progesterone, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Propranolol The p-glycoprotein inhibitor, Propranolol, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Quinidine The p-glycoprotein inhibitor, Quinidine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Ranolazine The p-glycoprotein inhibitor, Ranolazine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Reserpine The p-glycoprotein inhibitor, Reserpine, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Ritonavir The p-glycoprotein inhibitor, Ritonavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Saquinavir The p-glycoprotein inhibitor, Saquinavir, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Sunitinib The p-glycoprotein inhibitor, Sunitinib, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tacrolimus The p-glycoprotein inhibitor, Tacrolimus, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Tamoxifen The p-glycoprotein inhibitor, Tamoxifen, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Verapamil The p-glycoprotein inhibitor, Verapamil, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Food Interactions Not Available

Targets


DNA topoisomerase 1
Name DNA topoisomerase 1
Gene Name TOP1
Pharmacological action yes
Actions inhibitor
References
  • Schmidt F, Rieger J, Wischhusen J, Naumann U, Weller M: Glioma cell sensitivity to topotecan: the role of p53 and topotecan-induced DNA damage. Eur J Pharmacol. 2001 Jan 19;412(1):21-5. - Pubmed
  • strel'tsov SA, Mikheikin AL, Nechipurenko IuD: [Interaction of topotecan--a DNA topoisomerase I inhibitor--with dual-stranded polydeoxyribonucleotides. II. Formation of a complex containing several DNA molecules in the presence of topotecan] Mol Biol (Mosk). 2001 May-Jun;35(3):442-50. - Pubmed
  • Streltsov SA: Action models for the antitumor drug camptothecin: formation of alkali-labile complex with DNA and inhibition of human DNA topoisomerase I. J Biomol Struct Dyn. 2002 Dec;20(3):447-54. - Pubmed
  • Zhang J, Pu SP, Zhou YJ: [Preliminary study of apoptosis of human hepatocarcinoma cell line HepG2 induced by topotecan] Ai Zheng. 2002 Dec;21(12):1305-9. - Pubmed
  • Aisner J, Musanti R, Beers S, Smith S, Locsin S, Rubin EH: Sequencing topotecan and etoposide plus cisplatin to overcome topoisomerase I and II resistance: a pharmacodynamically based Phase I trial. Clin Cancer Res. 2003 Jul;9(7):2504-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Kollmannsberger C, Mross K, Jakob A, Kanz L, Bokemeyer C: Topotecan - A novel topoisomerase I inhibitor: pharmacology and clinical experience. Oncology. 1999;56(1):1-12. - Pubmed
  • Herben VM, ten Bokkel Huinink WW, Beijnen JH: Clinical pharmacokinetics of topotecan. Clin Pharmacokinet. 1996 Aug;31(2):85-102. - Pubmed
  • Dennis MJ, Beijnen JH, Grochow LB, van Warmerdam LJ: An overview of the clinical pharmacology of topotecan. Semin Oncol. 1997 Feb;24(1 Suppl 5):S5-12-S5-18. - Pubmed
DTHybrid score 1.154
DNA topoisomerase I, mitochondrial
Name DNA topoisomerase I, mitochondrial
Gene Name TOP1MT
Pharmacological action unknown
Actions inhibitor
References
  • Kosovsky MJ, Soslau G: Immunological identification of human platelet mitochondrial DNA topoisomerase I. Biochim Biophys Acta. 1993 Jun 24;1164(1):101-7. - Pubmed
DTHybrid score 0.3132
DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions intercalation
References
  • Staker BL, Hjerrild K, Feese MD, Behnke CA, Burgin AB Jr, Stewart L: The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15387-92. Epub 2002 Nov 8. - Pubmed
  • Pourquier P, Takebayashi Y, Urasaki Y, Gioffre C, Kohlhagen G, Pommier Y: Induction of topoisomerase I cleavage complexes by 1-beta -D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1885-90. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4134

Transporters


ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • Houghton PJ, Germain GS, Harwood FC, Schuetz JD, Stewart CF, Buchdunger E, Traxler P: Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer Res. 2004 Apr 1;64(7):2333-7. - Pubmed
  • Maliepaard M, van Gastelen MA, Tohgo A, Hausheer FH, van Waardenburg RC, de Jong LA, Pluim D, Beijnen JH, Schellens JH: Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918. Clin Cancer Res. 2001 Apr;7(4):935-41. - Pubmed
  • Sugimoto Y, Tsukahara S, Imai Y, Sugimoto Y, Ueda K, Tsuruo T: Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Mol Cancer Ther. 2003 Jan;2(1):105-12. - Pubmed
  • Maliepaard M, van Gastelen MA, de Jong LA, Pluim D, van Waardenburg RC, Ruevekamp-Helmers MC, Floot BG, Schellens JH: Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line. Cancer Res. 1999 Sep 15;59(18):4559-63. - Pubmed
  • Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH, Schellens JH, Schinkel AH: Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J Natl Cancer Inst. 2000 Oct 18;92(20):1651-6. - Pubmed
  • Allen JD, Van Dort SC, Buitelaar M, van Tellingen O, Schinkel AH: Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P-glycoprotein. Cancer Res. 2003 Mar 15;63(6):1339-44. - Pubmed
  • Breedveld P, Zelcer N, Pluim D, Sonmezer O, Tibben MM, Beijnen JH, Schinkel AH, van Tellingen O, Borst P, Schellens JH: Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res. 2004 Aug 15;64(16):5804-11. - Pubmed
  • Carcaboso AM, Elmeliegy MA, Shen J, Juel SJ, Zhang ZM, Calabrese C, Tracey L, Waters CM, Stewart CF: Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas. Cancer Res. 2010 Jun 1;70(11):4499-508. Epub 2010 May 11. - Pubmed
  • Shen J, Carcaboso AM, Hubbard KE, Tagen M, Wynn HG, Panetta JC, Waters CM, Elmeliegy MA, Stewart CF: Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid. Cancer Res. 2009 Jul 15;69(14):5885-92. Epub 2009 Jun 30. - Pubmed
  • Rocchi E, Khodjakov A, Volk EL, Yang CH, Litman T, Bates SE, Schneider E: The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane. Biochem Biophys Res Commun. 2000 Apr 29;271(1):42-6. - Pubmed
  • Ishii M, Iwahana M, Mitsui I, Minami M, Imagawa S, Tohgo A, Ejima A: Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6. Anticancer Drugs. 2000 Jun;11(5):353-62. - Pubmed
  • Yang CH, Schneider E, Kuo ML, Volk EL, Rocchi E, Chen YC: BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells. Biochem Pharmacol. 2000 Sep 15;60(6):831-7. - Pubmed
DTHybrid score 0.3216
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Collett A, Tanianis-Hughes J, Hallifax D, Warhurst G: Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo. Pharm Res. 2004 May;21(5):819-26. - Pubmed
  • Carcaboso AM, Elmeliegy MA, Shen J, Juel SJ, Zhang ZM, Calabrese C, Tracey L, Waters CM, Stewart CF: Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas. Cancer Res. 2010 Jun 1;70(11):4499-508. Epub 2010 May 11. - Pubmed
  • Shen J, Carcaboso AM, Hubbard KE, Tagen M, Wynn HG, Panetta JC, Waters CM, Elmeliegy MA, Stewart CF: Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid. Cancer Res. 2009 Jul 15;69(14):5885-92. Epub 2009 Jun 30. - Pubmed
DTHybrid score 0.4076

Predictions


Id Partner name Gene Name Score
3552 DNA topoisomerase 1 topA 1.154
4118 Cytochrome P450 3A5 CYP3A5 0.1262
4119 Cytochrome P450 2D6 CYP2D6 0.1097
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.1088
4757 Cytochrome P450 2C9 CYP2C9 0.0997
6016 Cytochrome P450 2C19 CYP2C19 0.0947
4200 Cytochrome P450 1A2 CYP1A2 0.0932
6107 Cytochrome P450 3A7 CYP3A7 0.0872
4924 Cytochrome P450 2C8 CYP2C8 0.0865
6030 Cytochrome P450 2B6 CYP2B6 0.0769
862 Multidrug resistance-associated protein 1 ABCC1 0.0743
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0736
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0671
587 Serum albumin ALB 0.0665
817 DNA topoisomerase 2-alpha TOP2A 0.0614
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0499
6024 Cytochrome P450 1A1 CYP1A1 0.0462
6013 Cytochrome P450 2E1 CYP2E1 0.0458
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0406
4604 Liver carboxylesterase 1 CES1 0.0387
6147 Solute carrier family 22 member 3 SLC22A3 0.0386
3923 Cholinesterase BCHE 0.0377
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0367
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0347
5718 Cytochrome P450 2A6 CYP2A6 0.0293
871 Glucocorticoid receptor NR3C1 0.028
776 Bile salt export pump ABCB11 0.027
1898 Cytochrome P450 1B1 CYP1B1 0.0266
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0265
1729 Solute carrier family 22 member 6 SLC22A6 0.0244
6145 Solute carrier family 22 member 1 SLC22A1 0.0244
3811 Cytochrome P450 19A1 CYP19A1 0.0226
136 Estrogen receptor ESR1 0.0224
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0221
20 Prostaglandin G/H synthase 1 PTGS1 0.0211
556 Alpha-1A adrenergic receptor ADRA1A 0.0209
6144 Solute carrier family 22 member 2 SLC22A2 0.0208
844 Epidermal growth factor receptor EGFR 0.0207
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0205
492 Histamine H1 receptor HRH1 0.0204
824 Sodium-dependent serotonin transporter SLC6A4 0.0198
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0195
6142 Solute carrier family 22 member 8 SLC22A8 0.0181
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0173
731 HIV-1 protease HIV-1 protease 0.0172
6137 Multidrug resistance-associated protein 6 ABCC6 0.0169
2164 Multidrug resistance-associated protein 4 ABCC4 0.0164
831 D(2) dopamine receptor DRD2 0.0162
6148 Multidrug resistance-associated protein 7 ABCC10 0.016
6106 Cytochrome P450 2C18 CYP2C18 0.0159
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0157
504 Mast/stem cell growth factor receptor KIT 0.0156
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0151
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0149
502 5-hydroxytryptamine 2A receptor HTR2A 0.0148
6143 Solute carrier family 22 member 7 SLC22A7 0.0145
320 5-hydroxytryptamine 1A receptor HTR1A 0.0142
847 Mu-type opioid receptor OPRM1 0.0141
103 Muscarinic acetylcholine receptor M1 CHRM1 0.014
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.013
290 Prostaglandin G/H synthase 2 PTGS2 0.0129
118 Organic cation/carnitine transporter 2 SLC22A5 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
193 Beta-1 adrenergic receptor ADRB1 0.0127
632 Alpha-1B adrenergic receptor ADRA1B 0.0127
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0126
318 Alpha-2A adrenergic receptor ADRA2A 0.0125
467 Delta-type opioid receptor OPRD1 0.0123
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
4120 NADPH--cytochrome P450 reductase POR 0.012
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0119
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0119
766 Beta-2 adrenergic receptor ADRB2 0.0118
29 Tubulin beta-1 chain TUBB1 0.0114
1024 Solute carrier family 22 member 11 SLC22A11 0.0113
228 Beta platelet-derived growth factor receptor PDGFRB 0.0113
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0113
260 Cytochrome P450 51 ERG11 0.0112
761 Cytochrome P450 51 ERG11 0.0112
3163 Cytochrome P450 51 cyp51 0.0112
6182 Cytochrome P450 2J2 CYP2J2 0.011
789 Alpha-1D adrenergic receptor ADRA1D 0.011
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0109
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0109
869 Estrogen receptor beta ESR2 0.0106
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0105
696 Kappa-type opioid receptor OPRK1 0.0104
23 D(1A) dopamine receptor DRD1 0.0104
117 Sterol O-acyltransferase 1 SOAT1 0.0104
614 Progesterone receptor PGR 0.0103
407 Vascular endothelial growth factor receptor 2 KDR 0.0103
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0101
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0101
26 Vascular endothelial growth factor receptor 3 FLT4 0.0101
6141 Sodium/bile acid cotransporter SLC10A1 0.0099
885 5-hydroxytryptamine 1B receptor HTR1B 0.0098
6599 HTH-type transcriptional regulator ttgR ttgR 0.0097
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0097
32 Vascular endothelial growth factor receptor 1 FLT1 0.0097
468 Cytochrome P450 4A11 CYP4A11 0.0097
4773 Deoxycytidine kinase DCK 0.0096
725 5-hydroxytryptamine 1D receptor HTR1D 0.0096
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0096
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0096
232 Corticosteroid-binding globulin SERPINA6 0.0091
33 Cystine/glutamate transporter SLC7A11 0.0091
274 Muscarinic acetylcholine receptor M5 CHRM5 0.009
161 Tubulin beta chain TUBB 0.0089
312 Tubulin beta chain TUB2 0.0089
756 Sex hormone-binding globulin SHBG 0.0089
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0088
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0088
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0088
713 Sodium-dependent dopamine transporter SLC6A3 0.0085
818 50S ribosomal protein L10 rplJ 0.0085
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0083
70 Type-1 angiotensin II receptor AGTR1 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
590 5-hydroxytryptamine 2C receptor HTR2C 0.0083
2539 Tubulin alpha-1 chain TUBA4A 0.0082
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0081
3947 Xanthine dehydrogenase/oxidase XDH 0.008
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
3941 Amine oxidase [flavin-containing] A MAOA 0.0077
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0077
952 Dipeptidyl peptidase 4 DPP4 0.0077
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0076
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0076
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0076
992 Protein tyrosine kinase 2 beta PTK2B 0.0076
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0074
629 Alpha-2B adrenergic receptor ADRA2B 0.0074
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0074
474 Acetylcholinesterase ACHE 0.0073
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0073
6031 Cytochrome P450 3A43 CYP3A43 0.0072
122 P2Y purinoceptor 12 P2RY12 0.0072
638 D(3) dopamine receptor DRD3 0.0071
68 Cannabinoid receptor 1 CNR1 0.0071
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0071
833 Organic cation/carnitine transporter 1 SLC22A4 0.007
1192 Sulfotransferase 1A1 SULT1A1 0.007
6136 Multidrug resistance-associated protein 5 ABCC5 0.007
1852 Microtubule-associated protein 2 MAP2 0.0069
373 Transthyretin TTR 0.0069
5787 Angiopoietin-1 receptor TEK 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0068
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0068
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
904 Glutathione S-transferase P GSTP1 0.0066
465 Calmodulin CALM1 0.0066
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0066
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0065
6220 Aryl hydrocarbon receptor AHR 0.0065
165 FL cytokine receptor FLT3 0.0063
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
378 Alpha-2C adrenergic receptor ADRA2C 0.0063
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0063
124 Histamine H2 receptor HRH2 0.0062
4237 50S ribosomal protein L22 rplV 0.0062
146 Androgen receptor AR 0.0062
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
738 Monocarboxylate transporter 1 SLC16A1 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
908 Glutathione S-transferase theta-1 GSTT1 0.0059
322 Vasopressin V2 receptor AVPR2 0.0058
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0058
341 5-hydroxytryptamine 3 receptor HTR3A 0.0058
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0058
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0058
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
2449 Tubulin alpha-3 chain TUBA1A 0.0056
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0055
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0055
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0055
477 DNA topoisomerase 4 subunit A parC 0.0054
886 DNA topoisomerase 4 subunit A parC 0.0054
6226 DNA topoisomerase 4 subunit A parC 0.0054
3856 Fibroblast growth factor receptor 3 FGFR3 0.0053
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0053
404 DNA gyrase subunit A gyrA 0.0053
6224 DNA gyrase subunit A gyrA 0.0053
1650 Heme carrier protein 1 SLC46A1 0.0053
380 Cytochrome P450 17A1 CYP17A1 0.0052
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0052
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
716 5-hydroxytryptamine 7 receptor HTR7 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
777 Tumor necrosis factor TNF 0.005
737 Mineralocorticoid receptor NR3C2 0.005
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.005
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0049
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0049
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0049
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0049
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
469 Annexin A1 ANXA1 0.0048
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0047
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
3939 Amine oxidase [flavin-containing] B MAOB 0.0047
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0047
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0047
239 Coagulation factor X F10 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
273 Apoptosis regulator Bcl-2 BCL2 0.0046
6163 Copper-transporting ATPase 2 ATP7B 0.0045
6165 Copper-transporting ATPase 1 ATP7A 0.0045
896 Glutathione S-transferase Mu 1 GSTM1 0.0045
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0045
811 Translocator protein TSPO 0.0044
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0044
511 5-hydroxytryptamine 1F receptor HTR1F 0.0044
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0044
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0044
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0044
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0044
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0044
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0044
106 Cannabinoid receptor 2 CNR2 0.0044
24 Thymidylate synthase TMP1 0.0043
359 Thymidylate synthase TYMS 0.0043
2626 Thymidylate synthase thyA 0.0043
2729 Thymidylate synthase thyA 0.0043
5352 Thymidylate synthase THYA 0.0043
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0043
432 D(4) dopamine receptor DRD4 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0042
6020 Aldehyde oxidase AOX1 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
4192 DNA topoisomerase 2-beta TOP2B 0.0041
1656 CYP2B protein CYP2B 0.0041
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
936 Ephrin type-A receptor 2 EPHA2 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
1757 Myeloperoxidase MPO 0.004
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.004
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.004
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0039
6824 Tyrosine-protein kinase Lyn LYN 0.0039
814 Ryanodine receptor 1 RYR1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1618 High affinity nerve growth factor receptor NTRK1 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0038
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0037
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0037
6167 Organic solute transporter subunit beta OSTB 0.0037
6166 Organic solute transporter subunit alpha OSTA 0.0037
723 Cytosolic phospholipase A2 PLA2G4A 0.0037
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0037
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0037
2599 Tyrosine-protein kinase HCK HCK 0.0036
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0036
3917 Methylenetetrahydrofolate reductase MTHFR 0.0036
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
823 Fibroblast growth factor receptor 2 FGFR2 0.0035
856 Vitamin D3 receptor VDR 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
3810 Catechol O-methyltransferase COMT 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
275 Arachidonate 5-lipoxygenase ALOX5 0.0035
939 50S ribosomal protein L3 rplC 0.0035
293 Gamma-glutamyl hydrolase GGH 0.0035
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0033
6014 Cytochrome P450 2A13 CYP2A13 0.0033
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0033
3809 Estrogen-related receptor gamma ESRRG 0.0033
6085 Fatty acid-binding protein, intestinal FABP2 0.0032
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0032
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0032
284 DNA-directed RNA polymerase beta chain rpoB 0.0032
5773 DNA-directed RNA polymerase beta chain rpoB 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
702 UMP-CMP kinase CMPK1 0.003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
295 Carbonic anhydrase 1 CA1 0.003
365 Dihydrofolate reductase DHFR 0.003
2381 Dihydrofolate reductase DFR1 0.003
2833 Dihydrofolate reductase Not Available 0.003
2931 Dihydrofolate reductase folA 0.003
3544 Dihydrofolate reductase folA 0.003
3682 Dihydrofolate reductase folA 0.003
6642 Dihydrofolate reductase folA 0.003
6756 Dihydrofolate reductase dfrA 0.003
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
6149 Solute carrier family 22 member 10 SLC22A10 0.0029
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0029
1629 Transcription factor AP-1 JUN 0.0029
319 Opioid receptor, sigma 1 OPRS1 0.0028
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
3932 Glutathione S-transferase A2 GSTA2 0.0028
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
2216 Fibroblast growth factor receptor 4 FGFR4 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
1063 Signal transducer and activator of transcription 5B STAT5B 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0027
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0027
4217 Telomerase reverse transcriptase TERT 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1010 Cytochrome P450 51A1 CYP51A1 0.0027
5300 Antigen peptide transporter 1 TAP1 0.0026
1178 Adenosine A2a receptor ADORA2A 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
49 Endothelin B receptor EDNRB 0.0026
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0026
427 Substance-P receptor TACR1 0.0026
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6837 Serine/threonine-protein kinase 17B STK17B 0.0025
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0025
1517 Beta-3 adrenergic receptor ADRB3 0.0024
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
528 5-hydroxytryptamine 1E receptor HTR1E 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
7 Nitric oxide synthase, inducible NOS2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
1256 5-hydroxytryptamine 6 receptor HTR6 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
6102 Arylamine N-acetyltransferase 2 NAT2 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
5798 Mitogen-activated protein kinase 11 MAPK11 0.0022
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0022
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0022
1050 Bile salt sulfotransferase SULT2A1 0.0021
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0021
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0021
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0021
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0021
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0021
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
1864 RET proto-oncogene RET 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0021
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0021
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0021
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0021
6432 Transporter snf 0.002
4203 Histamine N-methyltransferase HNMT 0.002
780 Retinoic acid receptor RXR-gamma RXRG 0.002
5626 Nucleoside diphosphate kinase B NME2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
760 Fibroblast growth factor 1 FGF1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
489 Monocarboxylate transporter 2 SLC16A7 0.0019
84 Nuclear receptor 0B1 NR0B1 0.0019
54 Prothrombin F2 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0018
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0018
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0018
2112 Toll-like receptor 9 TLR9 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0018
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0018
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
4122 Histone deacetylase 2 HDAC2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
3587 Gastrotropin FABP6 0.0017
16 Adenosine A1 receptor ADORA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0017
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0017
5294 Nucleoside diphosphate kinase A NME1 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
6174 50S ribosomal protein L32 rpmF 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0016
173 Toll-like receptor 7 TLR7 0.0016
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0016
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0016
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0016
6168 Solute carrier family 22 member 16 SLC22A16 0.0016
3233 Bile acid receptor NR1H4 0.0015
6755 Poliovirus receptor PVR 0.0015
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0015
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0015
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0014
1541 Metalloproteinase mmp20 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
5818 Folate receptor alpha FOLR1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
291 Nitric-oxide synthase, endothelial NOS3 0.0013
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0013
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
921 Glutamate receptor 2 GRIA2 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
1714 Mitogen-activated protein kinase 3 MAPK3 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
3957 Adenosine deaminase ADA 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
6859 Protein S100-A4 S100A4 0.0012
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0012
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
76 Nitric-oxide synthase, brain NOS1 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0011
4311 tRNA TRDMT1 0.0011
4325 tRNA trmD 0.0011
4328 tRNA trmD 0.0011
1630 Integrin beta-2 ITGB2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
976 Platelet glycoprotein IX GP9 0.0011
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
162 Retinoic acid receptor gamma-1 RARG 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0009
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0009
164 Histamine H4 receptor HRH4 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1648 Elastin ELN 0.0009
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
6044 Serum paraoxonase/lactonase 3 PON3 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
572 Integrin alpha-L ITGAL 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
1275 Estrogen sulfotransferase SULT1E1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
2981 Phospholipase A2, membrane associated PLA2G2A 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2207 Rhodopsin RHO 0.0007
5934 Cytochrome P450 26A1 CYP26A1 0.0007
6218 Pannexin-1 PANX1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
751 Potassium channel subfamily K member 6 KCNK6 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
3937 Fatty-acid amide hydrolase FAAH 0.0006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0006
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0006
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
172 Potassium channel subfamily K member 1 KCNK1 0.0006
6677 Myelin P2 protein PMP2 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0006
563 Thyroid peroxidase TPO 0.0006
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0006
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0006
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0006
634 Squalene monooxygenase SQLE 0.0006
7196 Squalene monooxygenase ERG1 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2021 Thrombomodulin THBD 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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