DT-Web

DB01268 - Sunitinib


Identification
Name Sunitinib
Accession Number DB01268 (DB07417)
Type small molecule
Description Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 398.4738
Groups approved
Monoisotopic Weight 398.211804333
Pharmacology
Indication For the treatment of advanced renal cell carcinoma as well as the treatment of gastrointestinal stromal tumor after disease progression on or intolerance to imatinib mesylate.
Mechanism of action Sunitinib is a small molecule that inhibits multiple RTKs, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic progression of cancer. Sunitinib was evaluated for its inhibitory activity against a variety of kinases (>80 kinases) and was identified as an inhibitor of platelet-derived growth factor receptors (PDGFRa and PDGFRb), vascular endothelial growth factor receptors (VEGFR1, VEGFR2 and VEGFR3), stem cell factor receptor (KIT), Fms-like tyrosine kinase-3 (FLT3), colony stimulating factor receptor Type 1 (CSF-1R), and the glial cell-line derived neurotrophic factor receptor (RET). Sunitinib inhibition of the activity of these RTKs has been demonstrated in biochemical and cellular assays, and inhibition of function has been demonstrated in cell proliferation assays. The primary metabolite exhibits similar potency compared to sunitinib in biochemical and cellular assays.
Absorption Maximum plasma concentrations (Cmax) of sunitinib are generally observed between 6 and 12 hours (Tmax) following oral administration. Food has no effect on the bioavailability of sunitinib. Sunitinib may be taken with or without food. The pharmacokinetics were similar in healthy volunteers and in the solid tumor patient populations tested, including patients with GIST and RCC.
Protein binding Binding of sunitinib and its primary metabolite to human plasma protein in vitro was 95% and 90%, respectively.
Biotransformation Sunitinib is metabolized primarily by the cytochrome P450 enzyme, CYP3A4, to produce its primary active metabolite, which is further metabolized by CYP3A4.
Route of elimination Sunitinib is metabolized primarily by the cytochrome P450 enzyme, CYP3A4, to produce its primary active metabolite, which is further metabolized by CYP3A4. Elimination is primarily via feces. In a human mass balance study of [14C]sunitinib, 61% of the dose was eliminated in feces, with renal elimination accounting for 16% of the administered dose.
Toxicity The maximally tolerated dose for rat, mouse, and dog when given orally is greater than 500 mg/kg. The maximally tolerated dose of a non-human primate is greater 1200 mg/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Atazanavir Possible increase in sunitinib levels
Bevacizumab Sunitinib may enhance the adverse/toxic effect of bevacizumab. Specifically, the risk for a specific form of anemia, microangiopathic hemolytic anemia (MAHA), may be increased. Bevacizumab may enhance the hypertensive effect of sunitinib. This combination is contraindicated.
Carbamazepine Possible decrease in sunitinib levels
Clarithromycin Possible increase in sunitinib levels
Dexamethasone Possible decrease in sunitinib levels
Indinavir Possible increase in sunitinib levels
Itraconazole Possible increase in sunitinib levels
Ketoconazole Possible increase in sunitinib levels
Lumefantrine Additive QTc-prolongation may occur. Concomitant therapy should be avoided.
Nefazodone Possible increase in sunitinib levels
Nelfinavir Possible increase in sunitinib levels
Phenobarbital Possible decrease in sunitinib levels
Phenytoin Possible decrease in sunitinib levels
Rifabutin Possible decrease in sunitinib levels
Rifampin Possible decrease in sunitinib levels
Tacrolimus Additive QTc-prolongation may occur increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Telithromycin Telithromycin may reduce clearance of Sunitinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sunitinib if Telithromycin is initiated, discontinued or dose changed.
Temsirolimus Co-administration of Temsirolimus and Sunitinib may result in serious adverse drug reactions.
Thiothixene May cause additive QTc-prolonging effects. Increased risk of ventricular arrhythmias. Consider alternate therapy. Thorough risk:benefit assessment is required prior to co-administration.
Topotecan The p-glycoprotein inhibitor, Sunitinib, may increase the bioavailability of oral Topotecan. A clinically significant effect is also expected with IV Topotecan. Concomitant therapy should be avoided.
Toremifene Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Consider alternate therapy. A thorough risk:benefit assessment is required prior to co-administration.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Trimipramine Additive QTc-prolongation may occur, increasing the risk of serious ventricular arrhythmias. Concomitant therapy should be used with caution.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of sunitinib by decreasing its metabolism. Additive QTc prolongation may also occur. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of sunitinib if voriconazole is initiated, discontinued or dose changed.
Vorinostat Additive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Ziprasidone Additive QTc-prolonging effects may increase the risk of severe arrhythmias. Concomitant therapy is contraindicated.
Zuclopenthixol Additive QTc prolongation may occur. Consider alternate therapy or use caution and monitor for QTc prolongation as this can lead to Torsade de Pointes (TdP).
Food Interactions Not Available

Targets


Beta platelet-derived growth factor receptor
Name Beta platelet-derived growth factor receptor
Gene Name PDGFRB
Pharmacological action yes
Actions antagonist
References
  • Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003 Jan;9(1):327-37. - Pubmed
  • Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM: SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther. 2003 May;2(5):471-8. - Pubmed
  • Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94. - Pubmed
  • Pietras K, Hanahan D: A multitargeted, metronomic, and maximum-tolerated dose - chemo-switch
  • Gollob JA: Sorafenib: scientific rationales for single-agent and combination therapy in clear-cell renal cell carcinoma. Clin Genitourin Cancer. 2005 Dec;4(3):167-74. - Pubmed
DTHybrid score 0.5368
Vascular endothelial growth factor receptor 1
Name Vascular endothelial growth factor receptor 1
Gene Name FLT1
Pharmacological action yes
Actions antagonist
References
  • O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM: An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clin Cancer Res. 2003 Nov 15;9(15):5465-76. - Pubmed
  • Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7. - Pubmed
DTHybrid score 0.7154
Mast/stem cell growth factor receptor
Name Mast/stem cell growth factor receptor
Gene Name KIT
Pharmacological action yes
Actions antagonist
References
  • Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM: SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther. 2003 May;2(5):471-8. - Pubmed
  • Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE: SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. 2003 Jul 15;63(14):4009-16. - Pubmed
  • Joensuu H: Second line therapies for the treatment of gastrointestinal stromal tumor. Curr Opin Oncol. 2007 Jul;19(4):353-8. - Pubmed
  • Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94. - Pubmed
  • Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.4763
Vascular endothelial growth factor receptor 2
Name Vascular endothelial growth factor receptor 2
Gene Name KDR
Pharmacological action unknown
Actions multitarget
References
  • Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res. 2003 Jan;9(1):327-37. - Pubmed
  • Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, McMahon G, Hallahan DE: SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. 2003 Jul 15;63(14):4009-16. - Pubmed
  • Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94. - Pubmed
  • Schoffski P, Dumez H, Clement P, Hoeben A, Prenen H, Wolter P, Joniau S, Roskams T, Van Poppel H: Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer: a review. Ann Oncol. 2006 Aug;17(8):1185-96. Epub 2006 Jan 17. - Pubmed
  • Amino N, Ideyama Y, Yamano M, Kuromitsu S, Tajinda K, Samizu K, Hisamichi H, Matsuhisa A, Shirasuna K, Kudoh M, Shibasaki M: YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clin Cancer Res. 2006 Mar 1;12(5):1630-8. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.5899
Vascular endothelial growth factor receptor 3
Name Vascular endothelial growth factor receptor 3
Gene Name FLT4
Pharmacological action unknown
Actions antagonist
References
  • Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7. - Pubmed
  • Deprimo SE, Bello CL, Smeraglia J, Baum CM, Spinella D, Rini BI, Michaelson MD, Motzer RJ: Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med. 2007 Jul 2;5:32. - Pubmed
  • Katoh Y, Katoh M: Comparative integromics on VEGF family members. Int J Oncol. 2006 Jun;28(6):1585-9. - Pubmed
  • Gridelli C, Maione P, Del Gaizo F, Colantuoni G, Guerriero C, Ferrara C, Nicolella D, Comunale D, De Vita A, Rossi A: Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer. Oncologist. 2007 Feb;12(2):191-200. - Pubmed
  • Ahmed SI, Thomas AL, Steward WP: Vascular endothelial growth factor (VEGF) inhibition by small molecules. J Chemother. 2004 Nov;16 Suppl 4:59-63. - Pubmed
DTHybrid score 0.4331
FL cytokine receptor
Name FL cytokine receptor
Gene Name FLT3
Pharmacological action unknown
Actions multitarget
References
  • O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A, Smolich BD, Manning WC, Murray LJ, Heinrich MC, Cherrington JM: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. Epub 2003 Jan 16. - Pubmed
  • O'Farrell AM, Foran JM, Fiedler W, Serve H, Paquette RL, Cooper MA, Yuen HA, Louie SG, Kim H, Nicholas S, Heinrich MC, Berdel WE, Bello C, Jacobs M, Scigalla P, Manning WC, Kelsey S, Cherrington JM: An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clin Cancer Res. 2003 Nov 15;9(15):5465-76. - Pubmed
  • Baratte S, Sarati S, Frigerio E, James CA, Ye C, Zhang Q: Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. J Chromatogr A. 2004 Jan 23;1024(1-2):87-94. - Pubmed
  • Schmidt-Arras D, Schwable J, Bohmer FD, Serve H: Flt3 receptor tyrosine kinase as a drug target in leukemia. Curr Pharm Des. 2004;10(16):1867-83. - Pubmed
  • Yee KW, Schittenhelm M, O'Farrell AM, Town AR, McGreevey L, Bainbridge T, Cherrington JM, Heinrich MC: Synergistic effect of SU11248 with cytarabine or daunorubicin on FLT3 ITD-positive leukemic cells. Blood. 2004 Dec 15;104(13):4202-9. Epub 2004 Aug 10. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2814
Macrophage colony-stimulating factor 1 receptor
Name Macrophage colony-stimulating factor 1 receptor
Gene Name CSF1R
Pharmacological action unknown
Actions other/unknown
References
  • Guo J, Marcotte PA, McCall JO, Dai Y, Pease LJ, Michaelides MR, Davidsen SK, Glaser KB: Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. Mol Cancer Ther. 2006 Apr;5(4):1007-13. - Pubmed
  • Roskoski R Jr: Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun. 2007 May 4;356(2):323-8. Epub 2007 Mar 7. - Pubmed
DTHybrid score 0.9995
Alpha platelet-derived growth factor receptor
Name Alpha platelet-derived growth factor receptor
Gene Name PDGFRA
Pharmacological action unknown
Actions antagonist
References
  • Prenen H, Cools J, Mentens N, Folens C, Sciot R, Schoffski P, Van Oosterom A, Marynen P, Debiec-Rychter M: Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate. Clin Cancer Res. 2006 Apr 15;12(8):2622-7. - Pubmed
DTHybrid score 0.5354

Enzymes


Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.5349
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.401
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
DTHybrid score 0.7437

Transporters


Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. Epub 2009 Sep 22. - Pubmed
DTHybrid score 0.2793
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. Epub 2009 Sep 22. - Pubmed
  • Shukla S, Robey RW, Bates SE, Ambudkar SV: Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos. 2009 Feb;37(2):359-65. Epub 2008 Oct 29. - Pubmed
DTHybrid score 0.6471
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inhibitor
References
  • Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. Epub 2009 Sep 22. - Pubmed
DTHybrid score 0.3456
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Hu S, Chen Z, Franke R, Orwick S, Zhao M, Rudek MA, Sparreboom A, Baker SD: Interaction of the multikinase inhibitors sorafenib and sunitinib with solute carriers and ATP-binding cassette transporters. Clin Cancer Res. 2009 Oct 1;15(19):6062-9. Epub 2009 Sep 22. - Pubmed
  • Dai CL, Liang YJ, Wang YS, Tiwari AK, Yan YY, Wang F, Chen ZS, Tong XZ, Fu LW: Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett. 2009 Jun 28;279(1):74-83. Epub 2009 Feb 18. - Pubmed
  • Shukla S, Robey RW, Bates SE, Ambudkar SV: Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2. Drug Metab Dispos. 2009 Feb;37(2):359-65. Epub 2008 Oct 29. - Pubmed
DTHybrid score 0.474

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2963
4924 Cytochrome P450 2C8 CYP2C8 0.2862
4757 Cytochrome P450 2C9 CYP2C9 0.2808
4200 Cytochrome P450 1A2 CYP1A2 0.2747
6016 Cytochrome P450 2C19 CYP2C19 0.2719
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.2066
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.1849
1128 Alpha-2-macroglobulin A2M 0.1817
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1781
6030 Cytochrome P450 2B6 CYP2B6 0.1711
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.1535
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.1508
3856 Fibroblast growth factor receptor 3 FGFR3 0.1479
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.1327
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.1157
862 Multidrug resistance-associated protein 1 ABCC1 0.1146
5787 Angiopoietin-1 receptor TEK 0.1101
587 Serum albumin ALB 0.1101
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.1037
823 Fibroblast growth factor receptor 2 FGFR2 0.0994
1618 High affinity nerve growth factor receptor NTRK1 0.098
776 Bile salt export pump ABCB11 0.0965
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0948
6024 Cytochrome P450 1A1 CYP1A1 0.0938
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0899
6013 Cytochrome P450 2E1 CYP2E1 0.0873
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0837
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0824
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0822
936 Ephrin type-A receptor 2 EPHA2 0.0821
5798 Mitogen-activated protein kinase 11 MAPK11 0.0774
6145 Solute carrier family 22 member 1 SLC22A1 0.074
1729 Solute carrier family 22 member 6 SLC22A6 0.0716
20 Prostaglandin G/H synthase 1 PTGS1 0.0709
6144 Solute carrier family 22 member 2 SLC22A2 0.068
760 Fibroblast growth factor 1 FGF1 0.0658
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0649
2599 Tyrosine-protein kinase HCK HCK 0.0634
2216 Fibroblast growth factor receptor 4 FGFR4 0.0626
6142 Solute carrier family 22 member 8 SLC22A8 0.0602
1898 Cytochrome P450 1B1 CYP1B1 0.0596
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.058
5718 Cytochrome P450 2A6 CYP2A6 0.0546
6824 Tyrosine-protein kinase Lyn LYN 0.0538
1864 RET proto-oncogene RET 0.0531
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0529
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0529
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0529
6136 Multidrug resistance-associated protein 5 ABCC5 0.0504
6148 Multidrug resistance-associated protein 7 ABCC10 0.0478
6143 Solute carrier family 22 member 7 SLC22A7 0.0451
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0443
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0426
871 Glucocorticoid receptor NR3C1 0.0389
817 DNA topoisomerase 2-alpha TOP2A 0.0374
6106 Cytochrome P450 2C18 CYP2C18 0.0373
290 Prostaglandin G/H synthase 2 PTGS2 0.0363
3811 Cytochrome P450 19A1 CYP19A1 0.0359
847 Mu-type opioid receptor OPRM1 0.0356
136 Estrogen receptor ESR1 0.0346
6137 Multidrug resistance-associated protein 6 ABCC6 0.0343
6141 Sodium/bile acid cotransporter SLC10A1 0.0342
118 Organic cation/carnitine transporter 2 SLC22A5 0.0336
492 Histamine H1 receptor HRH1 0.0331
1024 Solute carrier family 22 member 11 SLC22A11 0.033
824 Sodium-dependent serotonin transporter SLC6A4 0.0325
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0323
6031 Cytochrome P450 3A43 CYP3A43 0.0319
6147 Solute carrier family 22 member 3 SLC22A3 0.0304
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.03
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.03
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0299
731 HIV-1 protease HIV-1 protease 0.0293
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0292
1063 Signal transducer and activator of transcription 5B STAT5B 0.0291
556 Alpha-1A adrenergic receptor ADRA1A 0.0289
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0288
320 5-hydroxytryptamine 1A receptor HTR1A 0.0282
831 D(2) dopamine receptor DRD2 0.0277
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0266
614 Progesterone receptor PGR 0.0265
844 Epidermal growth factor receptor EGFR 0.0262
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0262
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0262
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0254
502 5-hydroxytryptamine 2A receptor HTR2A 0.0252
467 Delta-type opioid receptor OPRD1 0.0252
4604 Liver carboxylesterase 1 CES1 0.0251
484 Tyrosine-protein kinase ABL2 ABL2 0.0249
70 Type-1 angiotensin II receptor AGTR1 0.0248
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0247
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0244
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.024
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0236
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0229
1353 DNA topoisomerase 1 TOP1 0.0229
3552 DNA topoisomerase 1 topA 0.0229
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0225
477 DNA topoisomerase 4 subunit A parC 0.0223
886 DNA topoisomerase 4 subunit A parC 0.0223
6226 DNA topoisomerase 4 subunit A parC 0.0223
696 Kappa-type opioid receptor OPRK1 0.0219
404 DNA gyrase subunit A gyrA 0.0219
6224 DNA gyrase subunit A gyrA 0.0219
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0219
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0215
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0212
6182 Cytochrome P450 2J2 CYP2J2 0.0211
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.021
24 Thymidylate synthase TMP1 0.021
359 Thymidylate synthase TYMS 0.021
2626 Thymidylate synthase thyA 0.021
2729 Thymidylate synthase thyA 0.021
5352 Thymidylate synthase THYA 0.021
5626 Nucleoside diphosphate kinase B NME2 0.0207
1144 Hepatocyte growth factor receptor MET 0.0207
260 Cytochrome P450 51 ERG11 0.0205
761 Cytochrome P450 51 ERG11 0.0205
3163 Cytochrome P450 51 cyp51 0.0205
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0204
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0203
737 Mineralocorticoid receptor NR3C2 0.0199
318 Alpha-2A adrenergic receptor ADRA2A 0.0195
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0194
468 Cytochrome P450 4A11 CYP4A11 0.0191
632 Alpha-1B adrenergic receptor ADRA1B 0.019
738 Monocarboxylate transporter 1 SLC16A1 0.0188
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0187
29 Tubulin beta-1 chain TUBB1 0.0186
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0181
33 Cystine/glutamate transporter SLC7A11 0.0181
51 Muscarinic acetylcholine receptor M3 CHRM3 0.018
5294 Nucleoside diphosphate kinase A NME1 0.0179
3923 Cholinesterase BCHE 0.0178
638 D(3) dopamine receptor DRD3 0.0177
833 Organic cation/carnitine transporter 1 SLC22A4 0.0172
766 Beta-2 adrenergic receptor ADRB2 0.0172
4120 NADPH--cytochrome P450 reductase POR 0.0171
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.017
4148 Serine/threonine-protein kinase mTOR MTOR 0.0169
4773 Deoxycytidine kinase DCK 0.0169
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0165
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0165
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0164
23 D(1A) dopamine receptor DRD1 0.0163
756 Sex hormone-binding globulin SHBG 0.016
3947 Xanthine dehydrogenase/oxidase XDH 0.016
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0158
193 Beta-1 adrenergic receptor ADRB1 0.0155
232 Corticosteroid-binding globulin SERPINA6 0.0154
13 Aminomethyltransferase, mitochondrial AMT 0.0154
885 5-hydroxytryptamine 1B receptor HTR1B 0.0153
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0152
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0151
1650 Heme carrier protein 1 SLC46A1 0.0151
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.015
102 DNA topoisomerase I, mitochondrial TOP1MT 0.015
590 5-hydroxytryptamine 2C receptor HTR2C 0.015
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0147
713 Sodium-dependent dopamine transporter SLC6A3 0.0146
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0146
161 Tubulin beta chain TUBB 0.0146
312 Tubulin beta chain TUB2 0.0146
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0145
2539 Tubulin alpha-1 chain TUBA4A 0.014
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.014
6020 Aldehyde oxidase AOX1 0.014
341 5-hydroxytryptamine 3 receptor HTR3A 0.0139
6220 Aryl hydrocarbon receptor AHR 0.0139
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0138
1852 Microtubule-associated protein 2 MAP2 0.0138
725 5-hydroxytryptamine 1D receptor HTR1D 0.0135
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0135
908 Glutathione S-transferase theta-1 GSTT1 0.0135
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0134
789 Alpha-1D adrenergic receptor ADRA1D 0.0132
185 Vasopressin V1a receptor AVPR1A 0.0131
869 Estrogen receptor beta ESR2 0.013
117 Sterol O-acyltransferase 1 SOAT1 0.0129
273 Apoptosis regulator Bcl-2 BCL2 0.0128
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
322 Vasopressin V2 receptor AVPR2 0.0128
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0127
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0127
904 Glutathione S-transferase P GSTP1 0.0126
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0126
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0124
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
818 50S ribosomal protein L10 rplJ 0.0122
5923 Microtubule-associated protein tau MAPT 0.0121
5924 Microtubule-associated protein 4 MAP4 0.0121
378 Alpha-2C adrenergic receptor ADRA2C 0.0121
465 Calmodulin CALM1 0.012
952 Dipeptidyl peptidase 4 DPP4 0.0119
3917 Methylenetetrahydrofolate reductase MTHFR 0.0119
629 Alpha-2B adrenergic receptor ADRA2B 0.0119
275 Arachidonate 5-lipoxygenase ALOX5 0.0118
811 Translocator protein TSPO 0.0116
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0114
146 Androgen receptor AR 0.0114
6085 Fatty acid-binding protein, intestinal FABP2 0.0113
6599 HTH-type transcriptional regulator ttgR ttgR 0.0113
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0111
6167 Organic solute transporter subunit beta OSTB 0.011
6166 Organic solute transporter subunit alpha OSTA 0.011
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0108
2443 Azurin azu 0.0108
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0108
777 Tumor necrosis factor TNF 0.0106
293 Gamma-glutamyl hydrolase GGH 0.0105
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0104
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0103
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.01
3941 Amine oxidase [flavin-containing] A MAOA 0.01
380 Cytochrome P450 17A1 CYP17A1 0.01
768 FK506-binding protein 1A FKBP1A 0.01
469 Annexin A1 ANXA1 0.0099
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0099
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0098
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0098
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0098
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0097
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0097
2808 Chloramphenicol acetyltransferase 3 cat3 0.0097
432 D(4) dopamine receptor DRD4 0.0096
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0095
4237 50S ribosomal protein L22 rplV 0.0095
896 Glutathione S-transferase Mu 1 GSTM1 0.0095
1192 Sulfotransferase 1A1 SULT1A1 0.0094
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0094
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0094
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0093
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0092
6163 Copper-transporting ATPase 2 ATP7B 0.0091
6165 Copper-transporting ATPase 1 ATP7A 0.0091
6146 High affinity copper uptake protein 1 SLC31A1 0.0091
716 5-hydroxytryptamine 7 receptor HTR7 0.0091
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0089
1757 Myeloperoxidase MPO 0.0089
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0088
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0088
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0088
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0088
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0088
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0088
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0088
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0087
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0087
723 Cytosolic phospholipase A2 PLA2G4A 0.0087
702 UMP-CMP kinase CMPK1 0.0087
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0087
6149 Solute carrier family 22 member 10 SLC22A10 0.0086
461 Glycine receptor subunit alpha-3 GLRA3 0.0086
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0085
124 Histamine H2 receptor HRH2 0.0085
122 P2Y purinoceptor 12 P2RY12 0.0084
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0084
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0084
4192 DNA topoisomerase 2-beta TOP2B 0.0084
4238 50S ribosomal protein L4 rplD 0.0083
5578 50S ribosomal protein L4 rplD 0.0083
6173 50S ribosomal protein L4 rplD 0.0083
6219 50S ribosomal protein L4 rplD 0.0083
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0082
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0082
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0082
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
1648 Elastin ELN 0.0081
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0081
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
373 Transthyretin TTR 0.0079
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0078
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0078
1405 Thiopurine S-methyltransferase TPMT 0.0078
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0076
992 Protein tyrosine kinase 2 beta PTK2B 0.0076
718 Folate receptor gamma FOLR3 0.0075
299 Folate receptor beta FOLR2 0.0075
804 Mitochondrial folate transporter/carrier SLC25A32 0.0075
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0075
239 Coagulation factor X F10 0.0075
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
427 Substance-P receptor TACR1 0.0074
2449 Tubulin alpha-3 chain TUBA1A 0.0074
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0073
1656 CYP2B protein CYP2B 0.0073
474 Acetylcholinesterase ACHE 0.0073
1010 Cytochrome P450 51A1 CYP51A1 0.0073
342 P protein [Includes: DNA-directed DNA polymerase P 0.0072
612 P protein [Includes: DNA-directed DNA polymerase P 0.0072
68 Cannabinoid receptor 1 CNR1 0.0071
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.007
890 Niemann-Pick C1-like protein 1 NPC1L1 0.007
1629 Transcription factor AP-1 JUN 0.007
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.007
3587 Gastrotropin FABP6 0.007
5300 Antigen peptide transporter 1 TAP1 0.007
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
6171 Solute carrier family 28 member 3 SLC28A3 0.0068
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
1256 5-hydroxytryptamine 6 receptor HTR6 0.0067
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0067
705 Glutamate receptor 1 GRIA1 0.0067
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0066
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0066
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0065
131 Synaptic vesicular amine transporter SLC18A2 0.0065
3809 Estrogen-related receptor gamma ESRRG 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1760 Aminopeptidase N ANPEP 0.0063
6843 Aminopeptidase N pepN 0.0063
5482 Sialidase-2 NEU2 0.0062
3270 Elongation factor G fusA 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0062
3939 Amine oxidase [flavin-containing] B MAOB 0.0062
84 Nuclear receptor 0B1 NR0B1 0.0062
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0062
3685 Catabolite gene activator crp 0.0061
4655 Adenylate cyclase cyaC 0.0061
4759 Adenylate cyclase cyaB2 0.0061
814 Ryanodine receptor 1 RYR1 0.0061
6043 Putative G-protein coupled receptor 44 GPR44 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
208 DNA-directed RNA polymerase beta' chain rpoC 0.006
5774 DNA-directed RNA polymerase beta' chain rpoC 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
4217 Telomerase reverse transcriptase TERT 0.006
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0059
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0059
3957 Adenosine deaminase ADA 0.0058
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
3810 Catechol O-methyltransferase COMT 0.0056
94 5-hydroxytryptamine 4 receptor HTR4 0.0056
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0056
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0056
3932 Glutathione S-transferase A2 GSTA2 0.0055
1630 Integrin beta-2 ITGB2 0.0055
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0054
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0054
284 DNA-directed RNA polymerase beta chain rpoB 0.0054
5773 DNA-directed RNA polymerase beta chain rpoB 0.0054
319 Opioid receptor, sigma 1 OPRS1 0.0054
528 5-hydroxytryptamine 1E receptor HTR1E 0.0053
489 Monocarboxylate transporter 2 SLC16A7 0.0053
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0053
4760 Mll3241 protein mll3241 0.0052
163 D(1B) dopamine receptor DRD5 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0049
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0049
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0049
6033 High affinity interleukin-8 receptor A CXCR1 0.0049
4226 Uridine phosphorylase 2 UPP2 0.0049
1483 Membrane copper amine oxidase AOC3 0.0048
4122 Histone deacetylase 2 HDAC2 0.0048
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0048
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
1525 Heparin-binding growth factor 2 FGF2 0.0046
2320 Thymidine kinase, cytosolic TK1 0.0046
365 Dihydrofolate reductase DHFR 0.0046
2381 Dihydrofolate reductase DFR1 0.0046
2833 Dihydrofolate reductase Not Available 0.0046
2931 Dihydrofolate reductase folA 0.0046
3544 Dihydrofolate reductase folA 0.0046
3682 Dihydrofolate reductase folA 0.0046
6642 Dihydrofolate reductase folA 0.0046
6756 Dihydrofolate reductase dfrA 0.0046
6014 Cytochrome P450 2A13 CYP2A13 0.0046
2232 Interleukin-5 IL5 0.0045
1050 Bile salt sulfotransferase SULT2A1 0.0045
1593 Mucin-2 MUC2 0.0045
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0045
5818 Folate receptor alpha FOLR1 0.0045
7 Nitric oxide synthase, inducible NOS2 0.0045
4225 Uridine phosphorylase 1 UPP1 0.0045
54 Prothrombin F2 0.0045
6044 Serum paraoxonase/lactonase 3 PON3 0.0044
6837 Serine/threonine-protein kinase 17B STK17B 0.0044
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0044
511 5-hydroxytryptamine 1F receptor HTR1F 0.0044
1178 Adenosine A2a receptor ADORA2A 0.0044
106 Cannabinoid receptor 2 CNR2 0.0044
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0043
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0043
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0043
1517 Beta-3 adrenergic receptor ADRB3 0.0043
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0043
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
6102 Arylamine N-acetyltransferase 2 NAT2 0.0042
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0042
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0042
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0042
413 Amidophosphoribosyltransferase PPAT 0.0042
2515 Amidophosphoribosyltransferase purF 0.0042
3714 Amidophosphoribosyltransferase purF 0.0042
2981 Phospholipase A2, membrane associated PLA2G2A 0.0042
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0042
1196 Complement decay-accelerating factor CD55 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
6218 Pannexin-1 PANX1 0.0041
1569 G1/S-specific cyclin-D1 CCND1 0.0041
295 Carbonic anhydrase 1 CA1 0.0041
572 Integrin alpha-L ITGAL 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1313 Lactoylglutathione lyase GLO1 0.004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0039
357 Carbonic anhydrase 2 CA2 0.0038
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
183 Vascular endothelial growth factor A VEGFA 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0038
6211 Tubulin epsilon chain TUBE1 0.0037
6210 Tubulin delta chain TUBD1 0.0037
6212 Tubulin gamma-1 chain TUBG1 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0036
2112 Toll-like receptor 9 TLR9 0.0036
4203 Histamine N-methyltransferase HNMT 0.0036
16 Adenosine A1 receptor ADORA1 0.0036
856 Vitamin D3 receptor VDR 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
780 Retinoic acid receptor RXR-gamma RXRG 0.0035
3639 Thymidine phosphorylase deoA 0.0035
3936 Thymidine phosphorylase TYMP 0.0035
939 50S ribosomal protein L3 rplC 0.0035
645 Penicillin-binding protein 1A mrcA 0.0035
5805 Penicillin-binding protein 1A ponA 0.0035
6185 Penicillin-binding protein 1A mrcA 0.0035
6799 Penicillin-binding protein 1A pbpA 0.0035
976 Platelet glycoprotein IX GP9 0.0034
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6042 Prostaglandin reductase 2 PTGR2 0.0034
1714 Mitogen-activated protein kinase 3 MAPK3 0.0034
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0033
340 Apoptotic protease-activating factor 1 APAF1 0.0033
3601 Dihydropteroate synthase 1 folP1 0.0033
3807 Dihydropteroate synthase 1 folP1 0.0033
3808 Dihydropteroate synthase 2 folP2 0.0033
2417 Chloramphenicol acetyltransferase cat 0.0033
3278 Chloramphenicol acetyltransferase cat 0.0033
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0033
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0033
2810 Dr hemagglutinin structural subunit draA 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0032
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0032
2391 Ferrochelatase hemH 0.0032
6502 Ferrochelatase DKFZp686P18130 0.0032
1591 Ferrochelatase, mitochondrial FECH 0.0032
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0032
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0032
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0032
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0032
3086 Plasmepsin-2 Not Available 0.0032
88 Retinoic acid receptor RXR-beta RXRB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2021 Thrombomodulin THBD 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
153 Dopamine beta-hydroxylase DBH 0.0031
3913 Glutamic acid decarboxylase GAD65 0.0031
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0031
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0031
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0031
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0031
174 Sigma 1-type opioid receptor SIGMAR1 0.003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
115 Penicillin-binding protein 2 mrdA 0.003
6069 Penicillin-binding protein 2 mrdA 0.003
6118 Penicillin-binding protein 2 penA 0.003
6187 Penicillin-binding protein 2 pbpA 0.003
6686 Penicillin-binding protein 2 pbp2 0.003
6939 Penicillin-binding protein 2 mrdA 0.003
7163 Penicillin-binding protein 2 pbpA 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.003
6048 Troponin C, skeletal muscle TNNC2 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
207 Glutathione synthetase GSS 0.0029
5269 Glutathione synthetase gshB 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0029
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0028
1 Peptidoglycan synthetase ftsI ftsI 0.0028
4155 Peptidoglycan synthetase ftsI ftsI 0.0028
751 Potassium channel subfamily K member 6 KCNK6 0.0028
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0028
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0028
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0028
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0028
6493 Cytochrome c oxidase subunit 6C COX6C 0.0028
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0028
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0028
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0028
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0028
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0028
6559 Cytochrome c oxidase subunit 2 ctaC 0.0028
6669 Cytochrome c oxidase subunit 2 ctaC 0.0028
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0028
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0028
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0028
6558 Cytochrome c oxidase subunit 1 ctaD 0.0028
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
1176 Mitogen-activated protein kinase 1 MAPK1 0.0027
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
4311 tRNA TRDMT1 0.0027
4325 tRNA trmD 0.0027
4328 tRNA trmD 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
4041 Microsomal glutathione S-transferase 2 MGST2 0.0027
6432 Transporter snf 0.0027
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0027
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0027
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0026
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0026
6168 Solute carrier family 22 member 16 SLC22A16 0.0026
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0026
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
735 Alanine aminotransferase 1 GPT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
172 Potassium channel subfamily K member 1 KCNK1 0.0026
49 Endothelin B receptor EDNRB 0.0026
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0026
5304 UPF0166 protein TM_0021 TM_0021 0.0025
5293 Shikimate kinase 2 aroL 0.0025
5266 Activator of hgdC 0.0025
5287 Signaling protein Not Available 0.0025
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0025
5292 Putative partitioning protein TT_C1605 0.0025
3199 Phosphopantetheine adenylyltransferase coaD 0.0025
3543 Phosphopantetheine adenylyltransferase coaD 0.0025
3567 Phosphopantetheine adenylyltransferase coaD 0.0025
5289 Phosphopantetheine adenylyltransferase coaD 0.0025
5281 Plasmid segregation protein parM parM 0.0025
2874 Nitrogenase iron protein 1 nifH1 0.0025
4346 Polynucleotide kinase pseT 0.0025
921 Glutamate receptor 2 GRIA2 0.0025
5283 D-alanine--D-alanine ligase B ddlB 0.0025
5288 Shikimate kinase aroK 0.0025
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0025
5299 D-alanine--D-alanine ligase ddl 0.0025
6598 D-alanine--D-alanine ligase ddl 0.0025
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0025
5276 Chromosomal replication initiator protein dnaA dnaA 0.0025
5315 Chaperone protein htpG htpG 0.0025
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0025
5259 Transcriptional regulator ntrC1 0.0025
6699 Transcriptional regulator Cgl2612 0.0025
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0025
5284 Large T antigen Not Available 0.0025
5291 Glycogen synthase 1 glgA1 0.0025
5264 DNA replication protein REP 0.0025
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0025
5285 Kinesin heavy chain KIF5B 0.0025
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0025
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0025
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0025
5261 Phosphoribosylformylglycinamidine synthase purL 0.0025
5277 Preprotein translocase subunit secA secA 0.0025
5308 Preprotein translocase secA 1 subunit secA1 0.0025
2540 Choloylglycine hydrolase cbh 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
6501 Fatty acid-binding protein, liver FABP1 0.0024
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0024
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0024
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
6228 Nuclear receptor coactivator 1 NCOA1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
5934 Cytochrome P450 26A1 CYP26A1 0.0023
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0023
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0022
162 Retinoic acid receptor gamma-1 RARG 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
2091 Endoplasmin HSP90B1 0.0022
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0022
1792 Tissue-type plasminogen activator PLAT 0.0022
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
4031 Glutathione S-transferase A1 GSTA1 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
267 Plasminogen activator inhibitor 1 SERPINE1 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
3470 Hypothetical protein MG245 homolog MPN_348 0.0021
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0021
6277 Heat shock cognate 71 kDa protein HSPA8 0.0021
517 Alcohol dehydrogenase 1C ADH1C 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
5189 Trimethylamine dehydrogenase tmd 0.002
4106 Guanylate kinase GUK1 0.002
4516 Guanylate kinase gmk 0.002
4837 Cag-alfa cag-alfa 0.002
5646 Galactokinase GALK1 0.002
3390 Aminoglycoside 3'-phosphotransferase aphA 0.002
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.002
5302 TrwB trwB 0.002
4774 NTPase P4 Not Available 0.002
4839 DNA polymerase III subunit tau dnaX 0.002
5265 FtsH ftsH 0.002
4838 PMS1 protein homolog 2 PMS2 0.002
2270 Dephospho-CoA kinase coaE 0.002
2284 Adenylate kinase adk 0.002
2296 Adenylate kinase adk 0.002
2311 Adenylate kinase adk 0.002
2312 Adenylate kinase Not Available 0.002
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.002
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.002
3426 Glutamine synthetase glnA 0.002
3987 Glutamine synthetase GLUL 0.002
3175 Glutamate--cysteine ligase gshA 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
6500 Phospholipase A2 PLA2G1B 0.002
4034 Glutaredoxin-1 GLRX 0.002
4043 Glutaredoxin-2, mitochondrial GLRX2 0.002
910 Epididymal secretory glutathione peroxidase GPX5 0.002
903 Glutathione S-transferase A5 GSTA5 0.002
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.002
4037 Hypothetical protein GPX1 0.002
4297 Hypothetical protein SP_1951 0.002
4521 Hypothetical protein BC_2969 0.002
4540 Hypothetical protein TM_1070 0.002
4555 Hypothetical protein MT1739 0.002
4569 Hypothetical protein mshD 0.002
4578 Hypothetical protein PA3270 0.002
4747 Hypothetical protein PA3967 0.002
5177 Hypothetical protein TM_0096 0.002
5194 Hypothetical protein PA1204 0.002
5240 Hypothetical protein Rv2991 0.002
5370 Hypothetical protein TM_1158 0.002
5710 Hypothetical protein Tb927.5.1360 0.002
1928 Leukotriene C4 synthase LTC4S 0.002
4029 Microsomal glutathione S-transferase 3 MGST3 0.002
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.002
4032 Microsomal glutathione S-transferase 1 MGST1 0.002
4036 Glutathione peroxidase 6 GPX6 0.002
911 Glutathione peroxidase 3 GPX3 0.002
4040 Glutathione peroxidase 7 GPX7 0.002
907 Glutathione peroxidase 2 GPX2 0.002
906 Glutathione peroxidase 1 GPX1 0.002
4035 Glutathione S-transferase Mu 5 GSTM5 0.002
900 Glutathione S-transferase A4 GSTA4 0.002
4042 Glutathione transferase omega-2 GSTO2 0.002
4038 Glutathione peroxidase 4 GPX4 0.002
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.002
4033 S-formylglutathione hydrolase ESD 0.002
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
291 Nitric-oxide synthase, endothelial NOS3 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
2683 Mono-ADP-ribosyltransferase C3 C3 0.0019
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
5271 Focal adhesion kinase 1 PTK2 0.0018
6221 Steroid hormone receptor ERR1 ESRRA 0.0018
2390 Nonsecretory ribonuclease RNASE2 0.0018
5312 Kinesin-like protein KIF1A KIF1A 0.0018
2922 Glycerol kinase glpK 0.0018
76 Nitric-oxide synthase, brain NOS1 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
3319 Hydroxyacylglutathione hydrolase HAGH 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
712 Tubulin alpha chain TUB1 0.0018
898 Glutathione S-transferase A3 GSTA3 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
897 Glutathione S-transferase kappa 1 GSTK1 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
909 Maleylacetoacetate isomerase GSTZ1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
899 Glutathione S-transferase Mu 3 GSTM3 0.0017
905 Glutathione transferase omega-1 GSTO1 0.0017
1721 Glycogen synthase kinase-3 beta GSK3B 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0017
408 Riboflavin kinase RFK 0.0017
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0017
2615 Chemotaxis protein cheA cheA 0.0017
2371 Pantothenate kinase coaA 0.0017
2282 Protein recA recA 0.0017
2315 Protein recA recA 0.0017
2332 Protein recA recA 0.0017
5263 Protein recA recA 0.0017
2892 Acetylglutamate kinase argB 0.0017
3550 Acetylglutamate kinase argB 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
3669 Ribokinase rbsK 0.0017
1881 Hexokinase-1 HK1 0.0017
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0017
459 Retinoic acid receptor RXR-alpha RXRA 0.0017
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0016
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
2727 S-adenosylmethionine synthetase metK 0.0016
788 Creatine kinase M-type CKM 0.0016
2165 Glutathione S-transferase Mu 2 GSTM2 0.0016
173 Toll-like receptor 7 TLR7 0.0016
2697 Uridine-cytidine kinase 2 UCK2 0.0015
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0015
3233 Bile acid receptor NR1H4 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
2334 Dethiobiotin synthetase bioD 0.0015
6555 Dethiobiotin synthetase bioD 0.0015
6755 Poliovirus receptor PVR 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
901 Glutathione S-transferase Mu 4 GSTM4 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0015
48 Pyridoxal kinase PDXK 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0014
6395 Myosin-14 MYH14 0.0014
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
2251 Thymidylate kinase tmk 0.0014
2254 Thymidylate kinase DTYMK 0.0014
3522 Thymidylate kinase tmk 0.0014
1422 Serine/threonine-protein kinase 6 AURKA 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
3379 Kinesin-like protein KIF11 KIF11 0.0013
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0013
714 Glutathione reductase, mitochondrial GSR 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
3822 Actin, alpha skeletal muscle ACTA1 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
509 Thymidine kinase TK 0.0012
570 Thymidine kinase TK 0.0012
2559 Thymidine kinase TK 0.0012
3430 Thymidine kinase tdk 0.0012
3518 Thymidine kinase TK 0.0012
5301 Thymidine kinase tdk 0.0012
5771 Thymidine kinase ORF36 0.0012
7009 Thymidine kinase ORF36 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
292 Activin receptor type-1 ACVR1 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
6859 Protein S100-A4 S100A4 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
5682 Ribonuclease pancreatic RNASE1 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
6021 Adenosine kinase ADK 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
164 Histamine H4 receptor HRH4 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
229 Retinoic acid receptor beta RARB 0.0008
1867 Major prion protein PRNP 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1275 Estrogen sulfotransferase SULT1E1 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
2207 Rhodopsin RHO 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
3937 Fatty-acid amide hydrolase FAAH 0.0006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0006
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0006
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0006
6677 Myelin P2 protein PMP2 0.0006
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0006
563 Thyroid peroxidase TPO 0.0006
634 Squalene monooxygenase SQLE 0.0006
7196 Squalene monooxygenase ERG1 0.0006
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
3221 Cytochrome c4 cc4 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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