DT-Web

DB00112 - Bevacizumab


Identification
Name Bevacizumab
Accession Number DB00112 (BIOD00087, BTD00087)
Type biotech
Description A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and has a molecular weight of approximately 149 kilodaltons.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication As part of combination therapy for metastatic colorectal cancer and HER2-negative metastatic breast cancer.
Mechanism of action Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This prevents blood vessel proliferation and tumour metastasis.
Absorption Not Available
Protein binding Not Available
Biotransformation Most likely removed by opsonization via the reticuloendothelial system when bound to endothelial cells, or by human antimurine antibody production
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Sunitinib Sunitinib may enhance the adverse/toxic effect of bevacizumab. Specifically, the risk for a specific form of anemia, microangiopathic hemolytic anemia (MAHA), may be increased. Bevacizumab may enhance the hypertensive effect of sunitinib. This combination is contraindicated.
Food Interactions Not Available

Targets


Vascular endothelial growth factor A
Name Vascular endothelial growth factor A
Gene Name VEGFA
Pharmacological action yes
Actions Not Available
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Gerber HP, Ferrara N: Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res. 2005 Feb 1;65(3):671-80. - Pubmed
DTHybrid score 0.531
Low affinity immunoglobulin gamma Fc region receptor III-B
Name Low affinity immunoglobulin gamma Fc region receptor III-B
Gene Name FCGR3B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4607
Complement C1r subcomponent
Name Complement C1r subcomponent
Gene Name C1R
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3686
Complement C1q subcomponent subunit A
Name Complement C1q subcomponent subunit A
Gene Name C1QA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3847
Complement C1q subcomponent subunit B
Name Complement C1q subcomponent subunit B
Gene Name C1QB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3856
Complement C1q subcomponent subunit C
Name Complement C1q subcomponent subunit C
Gene Name C1QC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3856
Low affinity immunoglobulin gamma Fc region receptor III-A
Name Low affinity immunoglobulin gamma Fc region receptor III-A
Gene Name FCGR3A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4603
High affinity immunoglobulin gamma Fc receptor I
Name High affinity immunoglobulin gamma Fc receptor I
Gene Name FCGR1A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5494
Low affinity immunoglobulin gamma Fc region receptor II-a
Name Low affinity immunoglobulin gamma Fc region receptor II-a
Gene Name FCGR2A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4689
Low affinity immunoglobulin gamma Fc region receptor II-b
Name Low affinity immunoglobulin gamma Fc region receptor II-b
Gene Name FCGR2B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4655
Low affinity immunoglobulin gamma Fc region receptor II-c
Name Low affinity immunoglobulin gamma Fc region receptor II-c
Gene Name FCGR2C
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4745

Predictions


Id Partner name Gene Name Score
2782 Complement C1s subcomponent C1S 0.7705
75 B-lymphocyte antigen CD20 MS4A1 0.3345
724 Interleukin-2 receptor alpha chain IL2RA 0.1966
717 Interleukin-2 receptor subunit beta IL2RB 0.1965
844 Epidermal growth factor receptor EGFR 0.1663
93 CAMPATH-1 antigen CD52 0.1474
777 Tumor necrosis factor TNF 0.1474
757 Fusion glycoprotein F0 F 0.147
4875 Fusion glycoprotein F0 F 0.147
5377 Placenta growth factor PGF 0.1355
744 Myeloid cell surface antigen CD33 CD33 0.1349
793 T-cell surface antigen CD2 CD2 0.1302
1783 Intercellular adhesion molecule 1 ICAM1 0.1174
647 Integrin alpha-4 ITGA4 0.1173
1733 Vitronectin VTN 0.1155
572 Integrin alpha-L ITGAL 0.1081
5901 T-cell surface glycoprotein CD3 zeta chain CD247 0.108
1789 Lymphotoxin-alpha LTA 0.108
302 T-cell surface glycoprotein CD3 epsilon chain CD3E 0.108
5900 T-cell surface glycoprotein CD3 gamma chain CD3G 0.108
5899 T-cell surface glycoprotein CD3 delta chain CD3D 0.108
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.1079
955 Complement C5 C5 0.1033
5898 Complement C3 C3 0.103
2039 Integrin beta-3 ITGB3 0.1005
488 Integrin alpha-IIb ITGA2B 0.1004
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0836
554 Low-density lipoprotein receptor LDLR 0.0664
3811 Cytochrome P450 19A1 CYP19A1 0.0545
1334 Tissue factor pathway inhibitor TFPI 0.0471
290 Prostaglandin G/H synthase 2 PTGS2 0.0457
1719 Heparanase HPSE 0.0414
2058 P-selectin SELP 0.0373
309 Antithrombin-III SERPINC1 0.032
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0257
587 Serum albumin ALB 0.0246
4411 DNA protection during starvation protein dps 0.0197
5423 UPF0010 protein HI1317 HI_1317 0.0197
3780 Lipoprotein nlpI precursor nlpI 0.0197
5424 Endonuclease VIII-like 1 NEIL1 0.0197
5787 Angiopoietin-1 receptor TEK 0.0182
4757 Cytochrome P450 2C9 CYP2C9 0.0178
3164 Biotin synthase bioB 0.0173
3186 Soluble calcium-activated nucleotidase 1 CANT1 0.0172
660 T-cell surface glycoprotein CD1a CD1A 0.0172
6063 Major histocompatibility complex class I-related gene protein MR1 0.0172
5955 T-cell surface glycoprotein CD4 CD4 0.0172
6065 Integrin beta-1 ITGB1 0.0172
6066 Integrin alpha-V ITGAV 0.0172
5036 Small inducible cytokine A8 CCL8 0.017
4385 Cytochrome c' Not Available 0.017
4967 Cytochrome c' cycA 0.017
5038 Cytochrome c' Not Available 0.017
5223 Cytochrome c' cycP 0.017
5012 Ig lambda chain V-II region MGC Not Available 0.017
3583 6-phosphogluconolactonase pgl 0.0159
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0157
3221 Cytochrome c4 cc4 0.0156
3259 Autolysin lytA 0.0151
5023 Glycoside hydrolase Not Available 0.0148
5024 Glycoside hydrolase Not Available 0.0148
4771 Dissimilatory copper-containing nitrite reductase nir 0.0148
5006 RNASE4 protein RNASE4 0.0148
6016 Cytochrome P450 2C19 CYP2C19 0.0146
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0145
1654 Interleukin-1 beta IL1B 0.0145
4905 Cytochrome c2 Not Available 0.0143
4939 Cytochrome c2 cycA 0.0143
4964 Cytochrome c2 cycA 0.0143
4979 Cytochrome c2 cycA 0.0143
6673 Cytochrome c2 cycA 0.0143
942 T-lymphocyte activation antigen CD86 CD86 0.0138
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0137
494 Caspase-1 CASP1 0.0136
2149 Angiogenin ANG 0.0136
2430 Chondroitinase B cslB 0.0127
1507 Cytochrome c CYCS 0.0126
3030 Salivary alpha-amylase AMY1A 0.0123
1374 Natriuretic peptides B NPPB 0.0122
1827 Gap junction alpha-1 protein GJA1 0.0121
1908 Vascular cell adhesion protein 1 VCAM1 0.0121
2723 Cholera enterotoxin subunit B ctxB 0.0118
22 30S ribosomal protein S4 rpsD 0.0117
6714 30S ribosomal protein S4 rpsD 0.0117
2077 Caspase-3 CASP3 0.0116
6374 Disintegrin and metalloproteinase domain-containing protein 28 ADAM28 0.0116
65 Matrix metalloproteinase-9 Not Available 0.0112
140 30S ribosomal protein S9 rpsI 0.011
6719 30S ribosomal protein S9 rpsI 0.011
6725 30S ribosomal protein S9 rpsI 0.011
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0103
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0103
275 Arachidonate 5-lipoxygenase ALOX5 0.0098
4513 Pancreatic alpha-amylase AMY2A 0.0098
862 Multidrug resistance-associated protein 1 ABCC1 0.0097
4512 Cytochrome P450 3A4 CYP3A4 0.0095
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0089
1024 Solute carrier family 22 member 11 SLC22A11 0.008
6143 Solute carrier family 22 member 7 SLC22A7 0.0079
6142 Solute carrier family 22 member 8 SLC22A8 0.007
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0064
3947 Xanthine dehydrogenase/oxidase XDH 0.0064
1729 Solute carrier family 22 member 6 SLC22A6 0.0064
20 Prostaglandin G/H synthase 1 PTGS1 0.0058
193 Beta-1 adrenergic receptor ADRB1 0.0057
766 Beta-2 adrenergic receptor ADRB2 0.0056
556 Alpha-1A adrenergic receptor ADRA1A 0.005
6024 Cytochrome P450 1A1 CYP1A1 0.0048
6013 Cytochrome P450 2E1 CYP2E1 0.0045
4200 Cytochrome P450 1A2 CYP1A2 0.004
1588 Multidrug resistance protein 1 ABCB1 0.0038
4119 Cytochrome P450 2D6 CYP2D6 0.0038
4878 Glycoprotein hormones alpha chain CGA 0.0024
1072 Granzyme B GZMB 0.0024
4189 Alpha-galactosidase A GLA 0.0024
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0024
4889 Ig epsilon chain C region IGHE 0.0024
4877 Beta-mannanase man 0.0024
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0024
4850 Beta-2-glycoprotein 1 APOH 0.0024
4852 Reticulon-4 receptor RTN4R 0.0024
4880 Membrane cofactor protein CD46 0.0024
4856 CD209 antigen CD209 0.0024
4869 Major capsid protein A430L 0.0024
4845 ADAM 33 ADAM33 0.0024
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0024
1354 Beta-glucuronidase GUSB 0.0024
442 Envelope glycoprotein gp41 0.0024
4859 Envelope glycoprotein env 0.0024
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0024
4721 Beta-1,4-mannanase manA 0.0024
3352 Structural polyprotein Not Available 0.0024
3628 Structural polyprotein Not Available 0.0024
4892 Structural polyprotein Not Available 0.0024
1184 Interferon beta IFNB1 0.0021
6858 Inactive carboxylesterase 4 CES1P1 0.0021
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0021
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0021
4890 Hemagglutinin HA 0.0021
6566 Hemagglutinin Not Available 0.0021
4861 Interleukin-6 receptor alpha chain IL6R 0.0021
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0021
1379 Interleukin-12 subunit beta IL12B 0.0021
3837 Cytokine receptor common beta chain CSF2RB 0.0021
3444 Cyanovirin-N Not Available 0.002
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.002
1859 Prostatic acid phosphatase ACPP 0.002
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.002
852 Heparin cofactor 2 SERPIND1 0.002
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.002
3140 Hemagglutinin-neuraminidase HN 0.002
3609 Hemagglutinin-neuraminidase HN 0.002
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.002
2297 Genome polyprotein Not Available 0.002
2322 Genome polyprotein Not Available 0.002
2694 Genome polyprotein Not Available 0.002
2719 Genome polyprotein Not Available 0.002
2860 Genome polyprotein Not Available 0.002
2928 Genome polyprotein Not Available 0.002
3160 Genome polyprotein Not Available 0.002
3260 Genome polyprotein Not Available 0.002
4783 Genome polyprotein Not Available 0.002
5726 Genome polyprotein Not Available 0.002
5779 Genome polyprotein Not Available 0.002
5867 Genome polyprotein Not Available 0.002
6253 Genome polyprotein Not Available 0.002
6301 Genome polyprotein Not Available 0.002
6380 Genome polyprotein Not Available 0.002
6381 Genome polyprotein Not Available 0.002
6437 Genome polyprotein Not Available 0.002
6520 Genome polyprotein Not Available 0.002
6521 Genome polyprotein Not Available 0.002
6652 Genome polyprotein Not Available 0.002
6734 Genome polyprotein Not Available 0.002
6735 Genome polyprotein Not Available 0.002
6736 Genome polyprotein Not Available 0.002
6737 Genome polyprotein Not Available 0.002
6738 Genome polyprotein Not Available 0.002
6739 Genome polyprotein Not Available 0.002
6744 Genome polyprotein Not Available 0.002
6748 Genome polyprotein Not Available 0.002
6894 Genome polyprotein Not Available 0.002
6898 Genome polyprotein Not Available 0.002
4666 Fucose-binding lectin PA-IIL lecB 0.0019
2372 Bifunctional tail protein 9 0.0019
4787 Envelope glycoprotein gp160 env 0.0019
4820 Envelope glycoprotein gp160 env 0.0019
5727 Envelope glycoprotein gp160 env 0.0019
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0018
3480 Mannan endo-1,4-beta-mannosidase manA 0.0017
64 Neuraminidase NA 0.0017
641 Neuraminidase NA 0.0017
2676 Neuraminidase NA 0.0017
3026 Neuraminidase NA 0.0017
3519 Neuraminidase NA 0.0017
6007 Neuraminidase NA 0.0017
595 Fibrinogen alpha chain FGA 0.0017
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0017
1439 Lactotransferrin LTF 0.0017
1243 Cathepsin D CTSD 0.0016
958 Insulin-like growth factor 1 receptor IGF1R 0.0016
6307 Ig gamma-2 chain C region IGHG2 0.0015
2581 Chondroitinase AC cslA 0.0015
6847 Lactase-phlorizin hydrolase LCT 0.0015
6500 Phospholipase A2 PLA2G1B 0.0015
2207 Rhodopsin RHO 0.0014
4785 Ig gamma-1 chain C region IGHG1 0.0013
4604 Liver carboxylesterase 1 CES1 0.0013
76 Nitric-oxide synthase, brain NOS1 0.0013
952 Dipeptidyl peptidase 4 DPP4 0.0011
3923 Cholinesterase BCHE 0.0011
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